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151. Trends in U.S. Cardiovascular Care

Author

Masoudi, Frederick A., primary, Ponirakis, Angelo, additional, de Lemos, James A., additional, Jollis, James G., additional, Kremers, Mark, additional, Messenger, John C., additional, Moore, John W.M., additional, Moussa, Issam, additional, Oetgen, William J., additional, Varosy, Paul D., additional, Vincent, Robert N., additional, Wei, Jessica, additional, Curtis, Jeptha P., additional, Roe, Matthew T., additional, and Spertus, John A., additional

Published
2017
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153. Early Cessation of Adenosine Diphosphate Receptor Inhibitors Among Acute Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention

Author

Fosbøl, Emil L., primary, Ju, Christine, additional, Anstrom, Kevin J., additional, Zettler, Marjorie E., additional, Messenger, John C., additional, Waksman, Ron, additional, Effron, Mark B., additional, Baker, Brian A., additional, Cohen, David J., additional, Peterson, Eric D., additional, and Wang, Tracy Y., additional

Published
2016
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154. Impact of Proton Pump Inhibitor Use on the Comparative Effectiveness and Safety of Prasugrel Versus Clopidogrel: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE‐ACS) Study

Author

Jackson, Larry R., primary, Peterson, Eric D., additional, McCoy, Lisa A., additional, Ju, Christine, additional, Zettler, Marjorie, additional, Baker, Brian A., additional, Messenger, John C., additional, Faries, Douglas E., additional, Effron, Mark B., additional, Cohen, David J., additional, and Wang, Tracy Y., additional

Published
2016
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156. Temporal Trends in the Risk Profile of Patients Undergoing Outpatient Percutaneous Coronary Intervention

Author

Vora, Amit N., primary, Dai, Dadi, additional, Gurm, Hitinder, additional, Amin, Amit P., additional, Messenger, John C., additional, Mahmud, Ehtisham, additional, Mauri, Laura, additional, Wang, Tracy Y., additional, Roe, Matthew T., additional, Curtis, Jeptha, additional, Patel, Manesh R., additional, Dauerman, Harold L., additional, Peterson, Eric D., additional, and Rao, Sunil V., additional

Published
2016
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158. Transfemoral Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease in Child’s Class C Liver Disease Prior to Orthotopic Liver Transplantation

Author

Wilkey, Barbara J., primary, Hanson, Ross, additional, Reece, T. Brett, additional, Forman, Lisa, additional, Burton, James R., additional, Messenger, John C., additional, Kim, Michael S., additional, Cleveland, Joseph C., additional, Fiegel, Matt J., additional, Nydam, Trevor L., additional, and Mandell, M. Susan, additional

Published
2015
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159. Association of Physician Certification in Interventional Cardiology With In-Hospital Outcomes of Percutaneous Coronary Intervention

Author

Fiorilli, Paul N., primary, Minges, Karl E., additional, Herrin, Jeph, additional, Messenger, John C., additional, Ting, Henry H., additional, Nallamothu, Brahmajee K., additional, Lipner, Rebecca S., additional, Hess, Brian J., additional, Holmboe, Eric S., additional, Brennan, Joseph J., additional, and Curtis, Jeptha P., additional

Published
2015
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160. Abstract 16415: Switching of ADP Receptor Inhibitor After Hospital Discharge Among Myocardial Infarction Patients: Insights From the TRANSLATE-ACS Observational Study

Author

Zettler, Marjorie E, primary, Peterson, Eric D, additional, McCoy, Lisa A, additional, Effron, Mark B, additional, Anstrom, Kevin J, additional, Henry, Timothy D, additional, Baker, Brian A, additional, Messenger, John C, additional, Cohen, David J, additional, and Wang, Tracy Y, additional

Published
2015
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161. The Prevalence and Outcomes of Transradial Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: Analysis From the National Cardiovascular Data Registry (2007 to 2011)

Author

Baklanov, Dmitri V., Kaltenbach, Lisa A., Marso, Steven P., Subherwal, Sumeet S., Feldman, Dmitriy N., Garratt, Kirk N., Curtis, Jeptha P., Messenger, John C., and Rao, Sunil V.

Subjects
STEMI, surgical procedures, operative, radial access, PCI, cardiovascular diseases, bleeding, mortality, Article
Abstract

ObjectivesThe purpose of this study was to examine use and describe outcomes of radial access for percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI).BackgroundTransradial PCI (TRI) is associated with reduced risk of bleeding and vascular complications, as compared with femoral access PCI (FPCI). Studies have suggested that TRI may reduce mortality among patients with STEMI.MethodsWe examined 294,769 patients undergoing PCI for STEMI at 1,204 hospitals in the CathPCI Registry between 2007 and 2011. Patients were grouped according to access site used for PCI. The temporal trend in the rate of radial versus femoral approach was determined. For minimization of confounding, an inverse probability weighting analysis incorporating propensity scores was used to compare procedural success, post-PCI bleeding, door-to-balloon times, and in-hospital mortality between radial and femoral access.ResultsOver the 5-year period, the use of TRI versus FPCI in STEMI increased from 0.9% to 6.4% (p < 0.0001). There was no difference in procedural success. TRI was associated with longer median door-to-balloon time (78 vs. 74 min; p < 0.0001) but lower adjusted risk of bleeding (odds ratio [OR]: 0.62; 95% CI: 0.53 to 0.72; p < 0.0001) and lower adjusted risk of in-hospital mortality (OR: 0.76; 95% CI: 0.57 to 0.99; p = 0.0455).ConclusionsIn this large national database, use of radial access for PCI in STEMI increased over the study period. Despite longer door-to-balloon times, the radial approach was associated with lower bleeding rate and reduced in-hospital mortality. These data provide support to execute an adequately powered randomized controlled trial comparing radial and femoral approaches for PCI in STEMI.

Published
2012

163. Temporal Trends in and Factors Associated With Bleeding Complications Among Patients Undergoing Percutaneous Coronary Intervention: A Report From the National Cardiovascular Data CathPCI Registry

Author

Subherwal, Sumeet, Peterson, Eric D., Dai, David, Thomas, Laine, Messenger, John C., Xian, Ying, Brindis, Ralph G., Feldman, Dmitriy N., Senter, Shaun, Klein, Lloyd W., Marso, Steven P., Roe, Matthew T., and Rao, Sunil V.

Subjects
Male, Time Factors, Myocardial Infarction, Hemorrhage, Middle Aged, bleeding, outcomes, Article, surgical procedures, operative, Elective Surgical Procedures, Humans, Female, cardiovascular diseases, Angina, Unstable, Registries, Angioplasty, Balloon, Coronary, catheterization, Aged
Abstract

ObjectivesThe purpose of this study was to examine temporal trends in post-percutaneous coronary intervention (PCI) bleeding among patients with elective PCI, unstable angina (UA)/non–ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI).BackgroundThe impact of bleeding avoidance strategies on post-PCI bleeding rates over time is unknown.MethodsUsing the CathPCI Registry, we examined temporal trends in post-PCI bleeding from 2005 to 2009 among patients with elective PCI (n = 599,524), UA/NSTEMI (n = 836,103), and STEMI (n = 267,632). We quantified the linear time trend in bleeding using 3 sequential logistic regression models: 1) clinical factors; 2) clinical + vascular access strategies (femoral vs. radial, use of closure devices); and 3) clinical, vascular strategies + antithrombotic treatments (anticoagulant ± glycoprotein IIb/IIIa inhibitor [GPI]). Changes in the odds ratio for time trend in bleeding were compared using bootstrapping and converted to risk ratio.ResultsAn approximate 20% reduction in post-PCI bleeding was seen (elective PCI: 1.4% to 1.1%; UA/NSTEMI: 2.3% to 1.8; STEMI: 4.9% to 4.5%). Radial approach remained low (

Published
2012

165. Safety and clinical effectiveness of drug-eluting stents for saphenous vein graft intervention in older individuals: Results from the medicare-linked National Cardiovascular Data Registry®CathPCI Registry®(2005-2009)

Author

Brennan, J. Matthew, primary, Sketch, Michael H., additional, Dai, David, additional, Trilesskaya, Marina, additional, Al-Hejily, Wesam, additional, Rao, Sunil V., additional, Brilakis, Emmanouil, additional, Messenger, John C., additional, Shaw, Richard E., additional, Anstrom, Kevin J., additional, Peterson, Eric D., additional, and Douglas, Pamela S., additional

Published
2015
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166. Three-Year Outcomes Associated With Embolic Protection in Saphenous Vein Graft Intervention

Author

Brennan, J. Matthew, primary, Al-Hejily, Wesam, additional, Dai, David, additional, Shaw, Richard E., additional, Trilesskaya, Marina, additional, Rao, Sunil V., additional, Brilakis, Emmanouil S., additional, Anstrom, Kevin J., additional, Messenger, John C., additional, Peterson, Eric D., additional, Douglas, Pamela S., additional, and Sketch, Michael H., additional

Published
2015
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168. Response to Letter Regarding Article, “The Learning Curve for Transradial Percutaneous Coronary Intervention among Operators in the United States: A Study from the National Cardiovascular Data Registry”

Author

Hess, Connie N., primary, Peterson, Eric D., additional, Neely, Megan L., additional, Dai, David, additional, Hillegass, William B., additional, Krucoff, Mitchell W., additional, Kutcher, Michael A., additional, Messenger, John C., additional, Pancholy, Samir, additional, Piana, Robert N., additional, and Rao, Sunil V., additional

Published
2015
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169. Validated Contemporary Risk Model of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions: Insights From the National Cardiovascular Data Registry Cath‐PCI Registry

Author

Tsai, Thomas T., primary, Patel, Uptal D., additional, Chang, Tara I., additional, Kennedy, Kevin F., additional, Masoudi, Frederick A., additional, Matheny, Michael E., additional, Kosiborod, Mikhail, additional, Amin, Amit P., additional, Weintraub, William S., additional, Curtis, Jeptha P., additional, Messenger, John C., additional, Rumsfeld, John S., additional, and Spertus, John A., additional

Published
2014
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170. In-hospital switching between adenosine diphosphate receptor inhibitors in patients with acute myocardial infarction treated with percutaneous coronary intervention: Insights into contemporary practice from the TRANSLATE-ACS study

Author

Bagai, Akshay, primary, Peterson, Eric D, additional, Honeycutt, Emily, additional, Effron, Mark B, additional, Cohen, David J, additional, Goodman, Shaun G, additional, Anstrom, Kevin J, additional, Gupta, Anjan, additional, Messenger, John C, additional, and Wang, Tracy Y, additional

Published
2014
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176. TCT-494 Safety and Effectiveness of Prasugrel vs. Clopidogrel in the Setting of Bivalirudin vs. Heparin Use: 30-day Results from TRANSLATE-ACS

Author

Henry, Timothy D., primary, Peterson, Eric, additional, Cohen, David, additional, Ju, Christine, additional, Stone, Gregg W., additional, Messenger, John C., additional, Fonarow, Gregg C., additional, Effron, Mark B., additional, Baker, Brian A., additional, Zettler, Marjorie, additional, and Wang, Tracy Y., additional

Published
2014
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182. Early Post-Discharge Bleeding and Antiplatelet Therapy Discontinuation Among Acute Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention

Author

Wang, Tracy Y., primary, McCoy, Lisa, additional, Henry, Timothy D., additional, Effron, Mark B., additional, Messenger, John C., additional, Cohen, David J., additional, Mark, Daniel B., additional, Stone, Gregg W., additional, Zettler, Marjorie, additional, Singh, Mandeep, additional, Fonarow, Gregg C., additional, and Peterson, Eric D., additional

Published
2014
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184. Imaging techniques in transcatheter aortic valve replacement

Author

Quaife,Robert A, Dorosz,Jennifer, Messenger,John C, Salcedo,Ernesto E, Quaife,Robert A, Dorosz,Jennifer, Messenger,John C, and Salcedo,Ernesto E

Abstract

Robert A Quaife, Jennifer Dorosz, John C Messenger, Ernesto E Salcedo Division of Cardiology, University of Colorado, Aurora, CO, USA Abstract: Calcific aortic stenosis is now understood as a complex valvular degenerative process sharing many risk factors with atherosclerosis. Once patients develop symptomatic calcific aortic stenosis, the only effective treatment is aortic valve replacement. In the past decade, transcatheter aortic valve replacement (TAVR) has been developed as an alternative to surgery to treat severe calcific aortic stenosis. Cardiac imaging plays a pivotal role in the contemporary management of patients with calcific aortic stenosis, and particularly in patients being considered for TAVR, who demand detailed imaging of the aortic valve apparatus. In this review, we highlight the role of cardiac imaging for patient selection, procedural guidance, and evaluation of results of TAVR. Keywords: aortic stenosis, cardiovascular imaging, transcutaneous aortic valve replacement

Published
2013

186. Reply

Author

Masoudi, Frederick A., Messenger, John C., Weaver, W. Douglas, and Brindis, Ralph G.

Subjects
Cardiology and Cardiovascular Medicine
Published
2010

188. TCT-2 Comparative Effectiveness of Prasugrel vs. Clopidogrel Among Acute Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: 30-Day Outcomes from the TRANSLATE-ACS Observational Study

Author

Wang, Tracy Y., primary, Zettler, Marjorie, additional, Effron, Mark B., additional, McCoy, Lisa, additional, Anstrom, Kevin, additional, Fonarow, Gregg C., additional, Messenger, John C., additional, Stone, Gregg, additional, Cohen, David, additional, Henry, Timothy D., additional, and Peterson, Eric, additional

Published
2013
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190. Comparative effectiveness of drug-eluting stents on long-term outcomes in elderly patients treated for in-stent restenosis: A report from the National Cardiovascular Data Registry

Author

Kutcher, Michael A., primary, Brennan, J. Matthew, additional, Rao, Sunil V., additional, Dai, David, additional, Anstrom, Kevin J., additional, Mustafa, Nowwar, additional, Sedrakyan, Art, additional, Booth, Michael E., additional, Douglas, Pamela S., additional, and Messenger, John C., additional

Published
2013
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191. ACCF/AHA/SCAI 2013 Update of the Clinical Competence Statement on Coronary Artery Interventional Procedures

Author

Harold, John G., primary, Bass, Theodore A., additional, Bashore, Thomas M., additional, Brindis, Ralph G., additional, Brush, John E., additional, Burke, James A., additional, Dehmer, Gregory J., additional, Deychak, Yuri A., additional, Jneid, Hani, additional, Jollis, James G., additional, Landzberg, Joel S., additional, Levine, Glenn N., additional, McClurken, James B., additional, Messenger, John C., additional, Moussa, Issam D., additional, Muhlestein, J. Brent, additional, Pomerantz, Richard M., additional, Sanborn, Timothy A., additional, Sivaram, Chittur A., additional, White, Christopher J., additional, Williams, Eric S., additional, Halperin, Jonathan L., additional, Beckman, Joshua A., additional, Bolger, Ann, additional, Byrne, John G., additional, Lester, Steven J., additional, Merli, Geno J., additional, Pina, Ileana L., additional, Wang, Andrew, additional, and Weitz, Howard H., additional

Published
2013
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192. Adoption of Radial Access and Comparison of Outcomes to Femoral Access in Percutaneous Coronary Intervention

Author

Feldman, Dmitriy N., primary, Swaminathan, Rajesh V., additional, Kaltenbach, Lisa A., additional, Baklanov, Dmitri V., additional, Kim, Luke K., additional, Wong, S. Chiu, additional, Minutello, Robert M., additional, Messenger, John C., additional, Moussa, Issam, additional, Garratt, Kirk N., additional, Piana, Robert N., additional, Hillegass, William B., additional, Cohen, Mauricio G., additional, Gilchrist, Ian C., additional, and Rao, Sunil V., additional

Published
2013
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197. Use of short roll C-arm computed tomography and fully automated 3D analysis tools to guide transcatheter aortic valve replacement.

Author

Kim, Michael, Bracken, John, Eshuis, Peter, Chen, S., Fullerton, David, Cleveland, Joseph, Messenger, John, Carroll, John, Kim, Michael S, Chen, S Y James, Messenger, John C, and Carroll, John D

Abstract

Determination of the coplanar view is a critical component of transcatheter aortic valve replacement (TAVR). The safety and accuracy of a novel reduced angular range C-arm computed tomography (CACT) approach coupled with a fully automated 3D analysis tool package to predict the coplanar view in TAVR was evaluated. Fifty-seven patients with severe symptomatic aortic stenosis deemed prohibitive-risk for surgery and who underwent TAVR were enrolled. Patients were randomized 2:1 to CACT vs. angiography (control) in estimating the coplanar view. These approaches to determine the coplanar view were compared quantitatively. Radiation doses needed to determine the coplanar view were recorded for both the CACT and control patients. Use of CACT offered good agreement with the actual angiographic view utilized during TAVR in 34 out of 41 cases in which a CACT scan was performed (83 %). For these 34 cases, the mean angular magnitude difference, taking into account both oblique and cranial/caudal angulation, was 1.3° ± 0.4°, while the maximum difference was 7.3°. There were no significant differences in the mean total radiation dose delivered to patients between the CACT and control groups as measured by either dose area product (207.8 ± 15.2 Gy cm(2) vs. 186.1 ± 25.3 Gy cm(2), P = 0.47) or air kerma (1287.6 ± 117.7 mGy vs. 1098.9 ± 143.8 mGy, P = 0.32). Use of reduced-angular range CACT coupled with fully automated 3D analysis tools is a safe, practical, and feasible method by which to determine the optimal angiographic deployment view for guiding TAVR procedures. [ABSTRACT FROM AUTHOR]

Published
2016
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198. Transfemoral Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease in Child's Class C Liver Disease Prior to Orthotopic Liver Transplantation: A Case Report.

Author

Wilkey, Barbara J., Hanson, Ross, Reece, T. Brett, Forman, Lisa, Burton, James R., Messenger, John C., Kim, Michael S., Cleveland, Joseph C., Fiegel, Matt J., Nydam, Trevor L., Mandell, M. Susan, Burton, James R Jr, and Cleveland, Joseph C Jr

Subjects
AORTIC valve insufficiency, AORTIC stenosis, FATTY liver, FEMORAL artery, PROSTHETIC heart valves, LIVER transplantation, THROMBELASTOGRAPHY, DISEASE complications
Abstract

The American Association for the Study of Liver Diseases practice guidelines list severe cardiac disease as a contraindication to liver transplantation. Transcatheter aortic valve replacement has been shown to decrease all-cause mortality in patients with severe aortic stenosis who are not considered candidates for surgical aortic valve replacement. We report our experience of liver transplantation in a patient with severe aortic stenosis and moderate aortic insufficiency who underwent transcatheter aortic valve replacement with Child-Pugh Class C disease at a Model For End-Stage Liver Disease score of 29. The patient had a difficult post procedure course that was successfully medically managed. After liver transplantation the patient was discharged to home on postoperative day 11. The combination of cardiac disease and end stage liver disease is challenging but these patients can have a successful outcome despite very severe illness. [ABSTRACT FROM AUTHOR]

Published
2016
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199. The Impact of Bleeding Avoidance Strategies on Hospital-Level Variation in Bleeding Rates Following Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry CathPCI Registry.

Author

Vora, Amit N., Peterson, Eric D., McCoy, Lisa A., Garratt, Kirk N., Kutcher, Michael A., Marso, Steven P., Roe, Matthew T., Messenger, John C., and Rao, Sunil V.

Abstract

Objectives The aim of this study was to explore whether the use of bleeding avoidance strategies (BAS) explains variability in hospital-level bleeding following percutaneous coronary intervention. Background Prior studies have reported that bleeding rates following percutaneous coronary intervention vary markedly among hospitals, but the extent to which use of BAS explains this variation is unknown. Methods Using the American College of Cardiology National Cardiovascular Data Registry’s CathPCI Registry, estimated hospital-level bleeding rates from 2,459,686 procedures at 1,358 sites were determined. A series of models were fit to estimate random-effect variance, adjusting for patient risk (using the validated CathPCI bleeding risk model, C statistic = 0.77) and various combinations of BAS (transradial access, bivalirudin, vascular closure device use). The rate of any BAS use was also estimated for each hospital, and the association between percentage BAS use and predicted bleeding rates was determined. Results In total, 125,361 bleeding events (5.1%) were observed; patients experiencing bleeding events had lower rates of radial access (5.0% vs. 11.2%; p < 0.001), bivalirudin therapy (43.8% vs. 59.4%), and vascular closure device use (32.9% vs. 42.4%, p < 0.001) than those without bleeding. There was significant variation in bleeding rates across hospitals (median 5.0%; interquartile range [IQR]: 2.7% to 6.6%), which persisted after incorporating patient-level risk (median 5.1%; IQR: 4.0% to 4.4%). Patient factors accounted for 20% of the overall hospital-level variation, and radial access plus bivalirudin use accounted for an additional 7.8% of the overall hospital-level variation. The median hospital rate of any BAS use was 86.6% (IQR: 72.5% to 94.1%). A significant decrease in observed hospital-level bleeding was seen in hospitals above the median in BAS use (adjusted odds ratio: 0.90; 95% confidence interval: 0.88 to 0.93). Conclusions A modest proportion of the variation in hospitals’ rates of bleeding following percutaneous coronary intervention is attributable to differential use of BAS. Further analyses are required to determine the remaining approximately 70% causes of variation in percutaneous coronary intervention bleeding seen among hospitals. [ABSTRACT FROM AUTHOR]

Published
2016
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200. Multivessel vs culprit-only percutaneous coronary intervention among patients 65 years or older with acute myocardial infarction.

Author

Wang, Tracy Y., McCoy, Lisa A., Bhatt, Deepak L., Rao, Sunil V., Roe, Matthew T., Resnic, Frederic S., Cavender, Matthew A., Messenger, John C., and Peterson, Eric D.

Abstract

Background: Older adults presenting with acute myocardial infarction (MI) often have multivessel coronary artery disease amenable to percutaneous coronary intervention (PCI), yet the risks of multivessel intervention may outweigh potential benefits in these patients. We sought to determine if nonculprit intervention during the index PCI is associated with better outcomes among older patients with acute MI and multivessel disease.Methods: We examined 19,271 ST-segment elevation MI (STEMI) and 31,361 non-STEMI (NSTEMI) patients 65years or older with multivessel disease in a linked CathPCI Registry-Medicare database, excluding patients with prior coronary artery bypass grafting, left main disease, or cardiogenic shock. Using inverse probability-weighted propensity adjustment, we compared mortality between patients receiving culprit-only vs multivessel intervention during the index PCI procedure.Results: Most older MI patients (91% STEMI and 74% NSTEMI) received culprit-only intervention during the index PCI. Among STEMI patients, multivessel intervention during the index PCI was associated with higher 30-day mortality (8.3% vs 6.3%, adjusted hazard ratio [HR] 1.36, 95% CI 1.14-1.62) than culprit-only intervention, and this trend persisted at 1year (13.8% vs 12.2%, adjusted HR 1.14, 95% CI 0.99-1.31). No significant mortality differences were observed among NSTEMI patients at 30days (3.4% vs 4.1%, adjusted HR 1.01, 95% CI 0.88-1.15) or at 1year (10.1% vs 10.8%, adjusted HR 0.99, 95% CI 0.91-1.08).Conclusions: Nonculprit intervention during the index PCI was associated with worse outcomes among STEMI patients, but not NSTEMI patients. [ABSTRACT FROM AUTHOR]

Published
2016
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