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We prove a multiplicative version of the equivariant Barratt-Priddy-Quillen theorem, starting from the additive version proven in arXiv:1207.3459. The proof uses a multiplicative elaboration of an additive equivariant infinite loop space machine that manufactures orthogonal $G$-spectra from symmetric monoidal $G$-categories. The new machine produces highly structured associative ring and module $G$-spectra from appropriate multiplicative input. It relies on new operadic multicategories that are of considerable independent interest and are defined in a general, not necessarily equivariant or topological, context. Most of our work is focused on constructing and comparing them. We construct a multifunctor from the multicategory of symmetric monoidal $G$-categories to the multicategory of orthogonal $G$-spectra. With this machinery in place, we prove that the equivariant BPQ theorem can be lifted to a multiplicative equivalence. That is the heart of what is needed for the presheaf reconstruction of the category of $G$-spectra in arXiv:1110.3571.

Population increment and urbanization are responsible for producing higher amount of waste. Waste management is one of the major challenges to every country because that affects the environment in a serious manner. Government and nongovernmental organizations are working toward solutions for better waste management. Unorganized management of waste such as domestic waste, e-waste, industrial waste, and plastic waste creates many human problems such as pollution, diseases, and also affects the hygiene of living being. When waste generation rate increases lead to issue of finding new disposal places, proper waste disposal, collection, and management methods are needed. Management of waste includes proper collection, segregation, and recycling of discarded wastes in an environment friendly manner. In order to overcome all these problems, we propose the idea of modern waste management system in smart cities which manage waste in order to clean environment without interaction of human by blockchaining technology. Blockchaining is a super secure digital decentralized ledger, where transactions records are kept chronologically and publicly. Blockchaining waste management platform can provide the stakeholders with traceable and transparent way to regulate waste management activities and also achieve sustainable sanitation in waste management. Waste tracking is always difficult but with blockchaining, it must be easier. In this method, also connecting internet of things sensors with the decentralized network can help to generate the data and offer real-time tracking facility to garbage trucks throughout their journey. By implementing blockchaining methodology in waste management system also helpful in charging the penalties or financial rewards to the waste management service providers if they fail to provide better time-based services. Blockchaining can provide the public and the waste collection service with real-time information on trash bags so that they can always know whether they are full or empty.

La asuncion de nuevas interpretaciones con respecto al termino inclusion educativa y su evolucion dentro de los contextos educativo y social, impone cambios a la vision y la labor del maestro. Numerosos investigadores de diversas latitudes han escrito acerca de la definicion de inclusion educativa, sus caracteristicas, las barreras que impiden su concrecion, las experiencias positivas y buenas practicas existentes; realizando aportes que se convierten en fundamentos teorico-metodologicos a tomar en consideracion. Sin embargo, se ha podido constatar que no existen suficientes propuestas cientificas referidas al redimensionamiento del rol del maestro para favorecer la inclusion educativa de los alumnos con trastornos de la comunicacion oral. El objetivo de este articulo, basado en una investigacion predominantemente cualitativa, con la investigacion accion colaborativa como estrategia metodologica, y a partir de la aplicacion de una encuesta tipo Likert, es diagnosticar las actitudes de los maestros de educacion primaria con respecto a la inclusion educativa de los alumnos con trastornos de la comunicacion oral. Sobre la base de los resultados obtenidos se ofrecen criterios para el redimensionamiento del rol del maestro en funcion de este proposito. El estudio que se presenta podria enriquecer y transformar aspectos significativos en la aspiracion de construir escuelas cada vez mas inclusivas.

La presente investigación de tipo documental tiene como tema la administración y como subtema teoría de la administración y desarrollo en la gestión de calidad en las organizaciones. El objetivo general de esta investigación es describir las teorías de la administración y desarrollo en la gestión de calidad en las organizaciones como fuentes del conocimiento en las tomas de decisiones para la implementación de las posibles estrategias competitivas. La base teórica sustentada en este informe se presenta a través de cuatro capítulos, los cuales son: capítulo uno las generalidades de la administración, capítulo dos la gestión empresarial, capítulo tres las fuentes del conocimiento en la gestión de la calidad y capítulo cuatro la teoría de la administración y desarrollo de la gestión de la calidad. Las técnicas empleadas para la realización de este seminario de graduación fueron la lectura, recopilación y selección de información bibliográfica digital en la web y física, aplicando las normas APA 6ta. edición autor Javeriano, cumplimiento de la aplicación de la rúbrica de evaluación del departamento de administración de empresas y el cumplimiento de la estructura para presentación de informe de seminario según normativa de seminario de la UNAN Managua. Los términos que describen el informe son la introducción, justificación, objetivos del seminario, desarrollo del tema y subtema a través de los capítulos, conclusiones y bibliografía.

Temsirolimus has long been the only approved first-line standard of care (SOC) with overall survival (OS) benefit in poor-risk patients with advanced or metastatic renal cell cancer (mRCC). However, tyrosine kinase inhibitors are also commonly used in clinical practice. Pazopanib is an SOC for first-line mRCC treatment, but for poor-risk patients data are scarce. The FLIPPER (First-Line Pazopanib in Poor-Risk Patients with Metastatic Renal Cell Carcinoma) study aimed to assess efficacy and safety of first-line pazopanib in poor-risk mRCC patients. FLIPPER was a single-arm, multicenter, Phase IV trial. Key inclusion criteria were treatment-naive clear cell, inoperable advanced or mRCC, poor-risk according to MSKCC with slight modification, Karnofsky performance status (KPS) ≥60% and adequate organ function. Oral pazopanib 800 mg was given daily. Primary endpoint was the 6-month progression-free survival rate (PFS6). Secondary endpoints included PFS, OS, overall response rate (ORR), duration of response (DOR) and safety. For analysis, descriptive statistics were used. Between 2012 and 2016, 60 patients had been included. Forty-three patients qualified for safety analyses, 34 for efficacy. Median age was 66 years, 64.7% of patients were poor-risk, 82.4% had a KPS ≤70%. PFS6 was 35.3% (95% CI, 19.7-53.5). Median PFS and OS were 4.5 months (95% CI, 3.6-7.8) and 9.3 months (95% CI, 6.6-22.2), respectively. ORR was 32.4% (95% CI, 17.4-50.5), median DOR 9.7 months (95% CI, 1.8-12.4). The most common treatment-related grade 3/4 adverse event reported in 4.7% of patients was hypertension. No treatment-related death occurred. Since pazopanib is active and well tolerated in poor-risk patients with clear cell mRCC, our results support its use as first-line treatment in this setting.

Together with various hosts and environments, ubiquitous microbes interact closely with each other forming an intertwined system or community. Of interest, shifts of the relationships between microbes and their hosts or environments are associated with critical diseases and ecological changes. While advances in high-throughput Omics technologies offer a great opportunity for understanding the structures and functions of microbiome, it is still challenging to analyse and interpret the omics data. Specifically, the heterogeneity and diversity of microbial communities, compounded with the large size of the datasets, impose a tremendous challenge to mechanistically elucidate the complex communities. Fortunately, network analyses provide an efficient way to tackle this problem, and several network approaches have been proposed to improve this understanding recently. Here, we systemically illustrate these network theories that have been used in biological and biomedical research. Then, we review existing network modelling methods of microbial studies at multiple layers from metagenomics to metabolomics and further to multi-omics. Lastly, we discuss the limitations of present studies and provide a perspective for further directions in support of the understanding of microbial communities.

1+1 protection is a method to secure traffic between two nodes against failures in between. The sending node duplicates the traffic and forwards it over two disjoint paths. The receiving node assures that only a single copy of the traffic is further forwarded to its destination. In contrast to other protection schemes, this method prevents almost any packet loss in case of failures. 1+1 protection is usually applied on the optical layer, on Ethernet, or on MPLS. In this work we propose the application of 1+1 for P4-based IP networks. We define an 1+1 protection header for that purpose. We describe the behavior of sending and receiving nodes and provide a P4-based implementation for the BMv2 software switch and the hardware switch Tofino Edgecore Wedge 100BF-32X. We illustrate how to secure traffic, e.g. individual TCP flows, on the Internet with this approach. Finally, we present performance results showing that the P4-based implementation efficiently works on the Tofino Edgecore Wedge 100BF-32X., 5 pages, 4 figures

Imperviousness of the studied rural and urban goshawk territories.

Amount of all prey species in urban and rural habitats.

Electronic supplementary material for genetic identification of prey remains and statistical analysis

We studied phtototaxis, the directional movement relative to light in the bumblebee Bombus terrestris. We first developed and validated a MATLAB based system enabling reliable high-resolution tracking of a bumblebee relative to a changing LED light source. Our tracking protocol enables us to separate the phototaxis response from simple directional movement, overall levels of locomotor activity, or arousal state. We next used this system to compare the phototactic response of workers varying in their body size, age, or task performance. In all our experiments the bees showed a positive phototaxis. The strength of the phototactic response was influenced by body size but not age, and this effect was significant when the light source was weak. In one of two trials foragers that were larger showed stronger phototactic response than nurses when tested with the weak light source. Taken together, the evidence that phototaxis is associated with size-based division of labor in the bumblebee and with age-related division of labor in the honeybee, lend credence to response threshold models implicating the response to light in the organization of division of labor in cavity dwelling social insect.

M.M. was part of the Graduate School IMPact-Vector funded by the Senate Competition Committee grant (SAW-2014-SGN-3) of the Leibniz Association. M.M. is also an associated doctoral student of the GRK2046 from the German Research Foundation (DFG). We are grateful for additional funding (Jagdabgabe) from the ‘Stiftung Naturschutz Berlin' (J0056 & J0088), the ‘Ministerium für ländliche Entwicklung, Umwelt und Landwirtschaft des Landes Brandenburg' (35-21340/7+5-51/16), the ‘Behörde für Wirtschaft, Verkehr und Innovation der freien Hansestadt Hamburg' (title: ‘Gesundheitsstatus und Ausbreitungsverhalten von Habichtnestlingen in Hamburg') and the ‘Ministerium für Energiewende, Landwirtschaft, Umwelt und ländliche Räume des Landes Schleswig-Holstein’ (V 542–42902/2016). By 2040, roughly two-thirds of humanity are expected to live in urban areas. As cities expand, humans irreversibly transform natural ecosystems, creating both opportunities and challenges for wildlife. Here, we investigate how the Northern Goshawk (Accipiter gentilis) is adjusting to urban environments. We measured a variety of behavioural and ecological parameters in three urban and four rural study sites. City life appeared related to all parameters we measured. Urban female goshawks were overall 21.7 (CI95.13-130) times more likely to defend their nestlings from humans than rural females. Urban goshawks were 3.64 (CI95.05-6.66) times more likely to feed on pigeons and had diets exhibiting lower overall species richness and diversity. Urban females laid eggs 12.5 (CI95.12-17.4) days earlier than rural individuals and were 2.22 (CI95.984-4.73) times more likely to produce a brood of more than three nestlings. Nonetheless, urban goshawks suffered more from infections with the parasite Trichomonas gallinae, which was the second most common cause of mortality (14.6, after collisions with windows (33.1. In conclusion, although city life is associated with significant risks, goshawks appear to thrive in some urban environments, most likely as a result of high local availability of profitable pigeon prey. We conclude that the Northern Goshawk can be classified as an urban exploiter in parts of its distribution. Publisher PDF

We construct a map from the suspension $G$-spectrum $\Sigma_G^\infty M$ of a smooth compact $G$-manifold to the equivariant $A$-theory spectrum $A_G(M)$, and we show that its fiber is, on fixed points, a wedge of stable $h$-cobordism spectra. This map is constructed as a map of spectral Mackey functors, which is compatible with tom Dieck style splitting formulas on fixed points. In order to synthesize different definitions of the suspension $G$-spectrum as a spectral Mackey functor, we present a new perspective on spectral Mackey functors, viewing them as multifunctors on indexing categories for "rings on many objects" and modules over such. This perspective should be of independent interest., Comment: Improved exposition, reorganized and slightly expanded arguments in chapter 4

Recent work of Jonathan Campbell and Inna Zakharevich has focused on building machinery for studying scissors congruence problems via algebraic $K$-theory, and applying these tools to studying the Grothendieck ring of varieties. In this paper we give a new application of their framework: we construct a $K$-space that recovers the classical $\mathrm{SK}$ ("schneiden und kleben," German for "cut and paste") groups for manifolds on $\pi_0$, and we construct a derived version of the Euler characteristic., Comment: Final version

Rarefaction curves for prey species richness in urban and rural habitats.

Despite a rich literature on the effects of self-efficacy (SE) on various outcomes, there is little discussion of its effects on obsessive-compulsive disorder (OCD). The purpose of this study was to develop and validate the Facing-Contamination Self-Efficacy Scale (FC-SES), a measure of beliefs about one’s capability to face OCD-relevant contamination triggers. The final sample consisted of 129 participants, age 18 and over, who were recruited through Amazon’s Mechanical Turk. Factor structure, reliability, and validity were assessed using exploratory factor analysis, Cronbach’s alpha, and correlational analyses, respectively. Factor analysis yielded 2 clearly interpretable factors: human-related contamination (9 items), and animal-related contamination (5 items). The 14-item FC-SES demonstrated very good internal consistency reliability (α = .87), as well as good convergent and discriminant validity. Results suggest the FC-SES is a valid and reliable tool that can be used in future research exploring the relationship between SE and contamination-related OCD symptoms.