238 results on '"Mengfan Li"'
Search Results
152. What affects drivers’ satisfaction with autonomous vehicles in different road scenarios?
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Zhongxiang Feng, Shunying Zhu, Mengfan Li, and Weihua Zhang
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Computer science ,media_common.quotation_subject ,Transportation ,Workload ,Computer-assisted web interviewing ,Interpersonal communication ,Popularity ,Structural equation modeling ,Adaptability ,Transport engineering ,Risk perception ,Customer satisfaction ,General Environmental Science ,Civil and Structural Engineering ,media_common - Abstract
With the increasing popularity of autonomous vehicles, it is important to understand their user satisfaction because such aspects are likely to determine their future development. This article studied the effects of perceived benefit, perceived risk, interpersonal feelings, infrastructure adaptability, driving self-efficacy and mental workload on satisfaction when using autonomous vehicles, designed three road scenarios (simple, general, and complex), and established a structural equation model of satisfaction with mediators. A total of 553 responses were retrieved through online questionnaires, the path coefficients among various factors and indicators were calculated, and the importance of each factor in different road scenarios was discussed. The results show that the six factors have different association with user satisfaction in different road scenarios. The effect of mental workload on satisfaction in all road scenarios is mediated by self-efficacy. These results provide insights for the improvement of the autonomous vehicle industry.
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- 2021
153. Stitching interferometry using Computer-Generated Hologram (CGH) based on sub-aperture adjustment aberration of 2-D Chebyshev polynomial
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Shuai Zhang, Xi Hou, Jiahui Li, Mengfan Li, and Xiaochuan Hu
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Chebyshev polynomials ,Iterative method ,Aperture ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Holography ,02 engineering and technology ,Curvature ,01 natural sciences ,GeneralLiterature_MISCELLANEOUS ,law.invention ,010309 optics ,Image stitching ,Position (vector) ,law ,0103 physical sciences ,Electrical and Electronic Engineering ,ComputingMethodologies_COMPUTERGRAPHICS ,Mechanical Engineering ,Astrophysics::Instrumentation and Methods for Astrophysics ,021001 nanoscience & nanotechnology ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Interferometry ,0210 nano-technology ,Algorithm - Abstract
Limited by the field of view of the computer-generated hologram (CGH), full-aperture measurement of long cylindrical mirror with large curvature have been challenging. This paper reports a stitching interferometry based on sub-aperture adjustment with an aberration model represented by 2D Chebyshev polynomials. Firstly, a mathematical model under null measurement between the sub-aperture adjustment and its corresponding aberration is established by combining 2-D Chebyshev polynomials, which can correct sub-aperture position deviation. Secondly, on the basis of the adjustment aberration model, a global stitching algorithm based on the self-residual iterative algorithm (SRIA) is proposed. The algorithm uses the global stitching matrix and the sub-aperture spatial position constraint of the adjustment aberration model to iterate repeatedly for sub-aperture position. The experimental results verify the validity and feasibility of the proposed method. Finally, compared with full-aperture measurements using CGH, the proposed stitching method can obtain high-precision smooth stitching surface, and the repeatability is better than 0.7 nm RMS (P-V).
- Published
- 2021
154. The BABY BOOM Transcription Factor Activates the LEC1-ABI3-FUS3-LEC2 Network to Induce Somatic Embryogenesis
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Iris Heidmann, Baojian Chen, Mieke Weemen, Kim Boutilier, Jose M. Muiño, Anneke Horstman, Gerco C. Angenent, and Mengfan Li
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0301 basic medicine ,Genetics ,Regulation of gene expression ,biology ,Somatic embryogenesis ,Physiology ,Somatic cell ,Gene regulatory network ,Embryo ,Plant Science ,biology.organism_classification ,03 medical and health sciences ,030104 developmental biology ,Arabidopsis ,Life Science ,Laboratorium voor Moleculaire Biologie ,Arabidopsis thaliana ,Laboratory of Molecular Biology ,BIOS Plant Development Systems ,EPS ,Transcription factor - Abstract
Somatic embryogenesis is an example of induced cellular totipotency, where embryos develop from vegetative cells rather than from gamete fusion. Somatic embryogenesis can be induced in vitro by exposing explants to growth regulators and/or stress treatments. The BABY BOOM (BBM) and LEAFY COTYLEDON1 (LEC1) and LEC2 transcription factors are key regulators of plant cell totipotency, as ectopic overexpression of either transcription factor induces somatic embryo formation from Arabidopsis (Arabidopsis thaliana) seedlings without exogenous growth regulators or stress treatments. Although LEC and BBM proteins regulate the same developmental process, it is not known whether they function in the same molecular pathway. We show that BBM transcriptionally regulates LEC1 and LEC2, as well as the two other LAFL genes, FUSCA3 (FUS3) and ABSCISIC ACID INSENSITIVE3 (ABI3). LEC2 and ABI3 quantitatively regulate BBM-mediated somatic embryogenesis, while FUS3 and LEC1 are essential for this process. BBM-mediated somatic embryogenesis is dose and context dependent, and the contextdependent phenotypes are associated with differential LAFL expression. We also uncover functional redundancy for somatic embryogenesis among other Arabidopsis BBM-like proteins and show that one of these proteins, PLETHORA2, also regulates LAFL gene expression. Our data place BBM upstream of other major regulators of plant embryo identity and totipotency.
- Published
- 2017
155. An Event-Related Potential-Based Adaptive Model for Telepresence Control of Humanoid Robot Motion in an Environment Cluttered With Obstacles
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Mengfan Li, Feng Duan, Huihui Zhou, Genshe Chen, Linwei Niu, and Wei Li
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Social robot ,Visual perception ,Computer science ,business.industry ,020208 electrical & electronic engineering ,02 engineering and technology ,Visualization ,Robot control ,Support vector machine ,03 medical and health sciences ,0302 clinical medicine ,Control and Systems Engineering ,0202 electrical engineering, electronic engineering, information engineering ,Robot ,Computer vision ,Artificial intelligence ,Electrical and Electronic Engineering ,business ,030217 neurology & neurosurgery ,Humanoid robot - Abstract
This paper develops an event-related potential (ERP)-based adaptive model for the control of humanoid robot movements in an environment cluttered with obstacles based on live video feedback. This model adaptively determines the repetition number according to an individual’s mental state to speed up the robot control cycle. N200 and P300 potential features increase in the frontal and occipital areas when using robot images as visual stimuli, so it is able to effectively recognize target visual stimuli by processing Fisher’s linear discriminant analysis (FLDA) and to identify a subject’s intention by using support vector machine (SVM), in parallel. The offline evaluations show that, compared with a nonadaptive model, the adaptive model increases the accuracy rate from 88.8% to 92.9%, a change of 4.1%, and the information transfer rate (ITR) from 41.3 to 46.3 bits/min, a change of 5.0 bits/min. Eight subjects participated in telepresence controlling a NAO humanoid robot to move in an office environment cluttered with obstacles. The successful maneuvers demonstrate that the brain-controlled humanoid robot can be applied for surveillance and exploration in unknown environments based on live video feedback, which are evaluated by using new metrics for the performance of the brain–robot interaction (BRI) system.
- Published
- 2017
156. Tyrosinase Modified Poly(thionine) Electrodeposited Glassy Carbon Electrode for Amperometric Determination of Catechol
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MengFan Li, Shen Yang, Zhang Zhiqiang, ZhenYong Lu, and Yue Wang
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Catechol ,Chemistry ,Tyrosinase ,010401 analytical chemistry ,Glassy carbon electrode ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Amperometry ,Thionine ,0104 chemical sciences ,chemistry.chemical_compound ,Electrochemistry ,0210 nano-technology ,Nuclear chemistry - Published
- 2017
157. Inter-annual variations of Poyang Lake area during dry seasons: characteristics and implications
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Jing Yao, Zhiqiang Tan, Yunliang Li, Qi Zhang, and Mengfan Li
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010504 meteorology & atmospheric sciences ,dry seasons ,lake area–lake level relation ,0208 environmental biotechnology ,Drainage basin ,Water supply ,lcsh:River, lake, and water-supply engineering (General) ,02 engineering and technology ,01 natural sciences ,Hydrology (agriculture) ,Dry season ,medicine ,hydrodynamic model ,lcsh:Physical geography ,0105 earth and related environmental sciences ,Water Science and Technology ,Hydrology ,geography ,lcsh:TC401-506 ,geography.geographical_feature_category ,business.industry ,Discharge ,poyang lake ,020801 environmental engineering ,Lake water ,Period (geology) ,Dryness ,Environmental science ,medicine.symptom ,business ,lake area ,lcsh:GB3-5030 - Abstract
Variations in a lake area constitute an important indicator of the modifications of the lake hydrology. This paper explores the inter-annual variations of the Poyang Lake area during the dry seasons occurring within the 1961 to 2010 period and further quantifies the severity of dryness recently endured during the 2000s. A physically based hydrodynamic model of Poyang Lake established the relation between the lake area and lake level. The lake area was calculated using the observed lake water level. Results indicated the average lake area in the dry seasons was 1,015 km2. There was a considerable inter-annual variation of the minimum lake area that varied from 702.8 km2 to 1,259.7 km2. Poyang Lake experienced the most severe dryness in the 2000s, resulting in an average lake area during 2001 to 2010 of 124 km2 less than that of the preceding period. During the dry seasons, the catchment of the river discharge is likely the primary cause of the changes in lake area. This study evaluated the inter-annual variations of the Poyang Lake over a period of 50 years. Our results may provide support for an integrated management of the lake-catchment system, securing the water supply.
- Published
- 2016
158. Transient visual evoked potential -based method of detecting idle brain state in the event-related potential-based brain-computer interface
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Mengfan Li, Minghong Gong, Fang Lin, and Guizhi Xu
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genetic structures ,Computer science ,business.industry ,010401 analytical chemistry ,Pattern recognition ,02 engineering and technology ,Stimulus (physiology) ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Idle ,Brain state ,Event-related potential ,Artificial intelligence ,Evoked potential ,0210 nano-technology ,business ,Brain–computer interface - Abstract
Setting up an asynchronous event-related potential based brain-computer interface system is a challenge, since low signal-to-noise ratio of event-related potential makes it hard to discriminate the work and the idle states of a brain. We find the visual interface based on an odd-ball paradigm can simultaneously evoke event-related potential and transient visual evoked potential. The frequency of the transient visual evoked potential is modulated by the flashing rate of the visual stimulus that is used to induce event-related potential. This paper proposes an asynchronous brain-computer interface system that combines these two kinds of induced potentials to detect the two mental states in the time-frequency domain. The novel method achieves an accuracy of 96.50%. Compared with the traditional method, it improves the accuracy of 46.50%.
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- 2019
159. [A TrAdaBoost-based method for detecting multiple subjects' P300 potentials]
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Guizhi, Xu, Fang, Lin, Minghong, Gong, Mengfan, Li, and Hongli, Yu
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Support Vector Machine ,Brain-Computer Interfaces ,Discriminant Analysis ,Humans ,Electroencephalography ,Event-Related Potentials, P300 ,Algorithms - Abstract
Individual differences of P300 potentials lead to that a large amount of training data must be collected to construct pattern recognition models in P300-based brain-computer interface system, which may cause subjects' fatigue and degrade the system performance. TrAdaBoost is a method that transfers the knowledge from source area to target area, which improves learning effect in the target area. Our research purposed a TrAdaBoost-based linear discriminant analysis and a TrAdaBoost-based support vector machine to recognize the P300 potentials across multiple subjects. This method first trains two kinds of classifiers separately by using the data deriving from a small amount of data from same subject and a large amount of data from different subjects. Then it combines all the classifiers with different weights. Compared with traditional training methods that use only a small amount of data from same subject or mixed different subjects' data to directly train, our algorithm improved the accuracies by 19.56% and 22.25% respectively, and improved the information transfer rate of 14.69 bits/min and 15.76 bits/min respectively. The results indicate that the TrAdaBoost-based method has the potential to enhance the generalization ability of brain-computer interface on the individual differences.P300 电位的个体差异导致基于该电位的脑-机交互系统需要每位被试的大量训练数据来构建模式识别模型,引起被试的训练疲劳,并可能由此导致系统性能降低。TrAdaBoost 是一种把源领域的知识迁移到目标领域,进而使目标领域能获得更好的学习效果的迁移学习方法。本研究针对 P300 电位的跨脑辨识问题,提出基于 TrAdaBoost 的线性判别分类算法和支持向量机,将同被试的少量数据训练的分类器与不同被试的大量数据训练的分类器按权重组成融合分类器。与只采用少量同被试数据或者混合不同被试数据来直接进行训练的传统学习方式相比,本文算法在少量样本情况下将准确率分别提高了 19.56% 和 22.25%,信息传输率分别提高了 14.69 bits/min 和 15.76 bits/min,有望提高脑-机交互系统对被试个体差异的泛化能力。.
- Published
- 2019
160. Architectural proteins for the formation and maintenance of the 3D genome
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Mengfan Li, Cheng Li, Junsheng Yang, Jingbo Gan, Yuao Sun, Zihan Xu, and Yujie Sun
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0301 basic medicine ,CCCTC-Binding Factor ,Chromosomal Proteins, Non-Histone ,Cell Cycle Proteins ,Computational biology ,Biology ,Genome ,General Biochemistry, Genetics and Molecular Biology ,Phase Transition ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Humans ,Transcription factor ,General Environmental Science ,Regulation of gene expression ,Cohesin ,Chromosome ,Chromatin ,Lamins ,030104 developmental biology ,Gene Expression Regulation ,CTCF ,030220 oncology & carcinogenesis ,Nucleic Acid Conformation ,General Agricultural and Biological Sciences ,Lamin ,Transcription Factors - Abstract
Eukaryotic genomes are densely packaged into hierarchical three-dimensional (3D) structures that contain information about gene regulation and many other biological processes. With the development of imaging and sequencing-based technologies, 3D genome studies have revealed that the high-order chromatin structure is composed of hierarchical levels, including chromosome territories, A/B compartments, topologically associated domains, and chromatin loops. However, how this chromatin architecture is formed and maintained is not completely clear. In this review, we introduce experimental methods to investigate the 3D genome, review major architectural proteins that regulate 3D chromatin organization in mammalian cells, such as CTCF (CCCTC-binding factor), cohesin, lamins, and transcription factors, and discuss relevant mechanisms such as phase separation.
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- 2019
161. Chromatin-lamin B1 interaction promotes genomic compartmentalization and constrains chromatin dynamics
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Yingping Hou, Boxin Xue, Shipeng Shao, Ruifeng Li, Lei Chang, Cheng Li, Yujie Sun, Mengfan Li, and Yiwen Zhang
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Eukaryotic genome ,Chemistry ,Chromosomal Territory ,Genome ,Lamin ,Chromatin ,Cell biology - Abstract
The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome functions. However, the molecular machinery underlying these hierarchically organized chromatin architecture and dynamics remains poorly understood. Here by combining imaging and Hi-C sequencing, we studied the role of lamin B1 in chromatin architecture and dynamics. We found that lamin B1 depletion leads to chromatin redistribution and decompaction. Consequently, the inter-chromosomal interactions and overlap between chromosome territories are increased. Moreover, Hi-C data revealed that lamin B1 is required for the integrity and segregation of chromatin compartments but not for the topologically associating domains (TADs). We further proved that depletion of lamin B1 leads to increased chromatin dynamics, owing to chromatin decompaction and redistribution toward nuclear interior. Taken together, our data suggest that chromatin-lamin B1 interactions promote chromosomal territory segregation and genomic compartmentalization, and confine chromatin dynamics, supporting its crucial role in chromatin higher-order structure and dynamics.
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- 2019
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162. Study on Low Temperature Cracking Resistance of Carbon Fiber Geogrid Reinforced Asphalt Pavement Surface Combined Body
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Zhiqiang Wang, Guangqing Yang, Xin Wang, Xunmei Liang, Mengfan Liu, and Hao Zhang
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road engineering ,surface combined body ,carbon fiber geogrid ,low-temperature bending damage test ,low-temperature cracking resistance ,Organic chemistry ,QD241-441 - Abstract
Currently, there are limitations in the research on the use of carbon fiber geogrids to prevent low-temperature cracking in asphalt pavements. This study aims to comparatively investigate the effects of carbon fiber-based geogrid type and dense-graded asphalt concrete mixture (AC) surface combined body (SCB) type on the low-temperature cracking resistance of reinforced asphalt pavement through low-temperature bending damage tests. Two geogrid types were prepared: a carbon fiber geogrid (CCF) and a glass/carbon fiber composite qualified geogrid (GCF). Two SCB types were studied: AC-13/AC-20 and AC-20/AC-25. The results show that the improvement in the flexural tensile strength of CCF is similar to that for GCF. Moreover, under reinforced conditions, the improvement in the low-temperature cracking resistance of AC-20/AC-25 is better than that for AC-13/AC-20 by 16.26–24.57%. Based on the analysis, the reasonable ratio range of the aperture sizes to the major particle sizes in the dense gradation can achieve a more effective interlocking effect. This can improve the low-temperature cracking resistance of carbon fiber-based geogrid-reinforced samples. Then, increasing the bending absorption energy is a key way of improving the low-temperature cracking resistance of carbon fiber-based geogrid reinforcements. Eventually, the fracture type of carbon fiber-based geogrid-reinforced samples is a mixed plastic–brittle fracture. These results can provide a reference for the road failure analysis of geogrid-reinforced asphalt pavement.
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- 2024
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163. Repetitive transcranial magnetic stimulation improves cognitive function of Alzheimer's disease patients
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Mengfan Li, Wenwen Yu, Yannan Cong, Zhenguang Li, Jinbiao Zhang, Junwu Zhao, Na Geng, Ming Tan, Haixia Zhang, and Peiyan Shan
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0301 basic medicine ,Male ,medicine.medical_specialty ,Neurology ,medicine.medical_treatment ,Verbal learning ,behavioral disciplines and activities ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,Alzheimer Disease ,Severity of illness ,mental disorders ,rTMS ,medicine ,Humans ,cognitive function ,Aged ,business.industry ,Neuropsychology ,Montreal Cognitive Assessment ,AD ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Transcranial Magnetic Stimulation ,Transcranial magnetic stimulation ,030104 developmental biology ,Treatment Outcome ,Oncology ,Physical therapy ,Female ,Cholinesterase Inhibitors ,Alzheimer's disease ,Clinical Research Paper ,business ,030217 neurology & neurosurgery - Abstract
// Junwu Zhao 1,2 , Zhenguang Li 2 , Yannan Cong 2 , Jinbiao Zhang 2 , Ming Tan 2 , Haixia Zhang 2 , Na Geng 2 , Mengfan Li 2 , Wenwen Yu 3 and Peiyan Shan 1 1 Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China 2 Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China 3 Department of Clinical Medicine (Neurology), Weifang Medical University, Weifang, Shandong, China Correspondence to: Peiyan Shan, email: // Keywords : rTMS, cognitive function, AD Received : September 12, 2016 Accepted : October 24, 2016 Published : November 03, 2016 Abstract Repetitive transcranial magnetic stimulation (rTMS) acts as a kind of widely-applied and non-invasive method in the intervention of some neurological disorders. This prospective, randomized, double-blind, placebo-controlled trial investigates the effect of rTMS on 30 cases of Alzheimer’s disease (AD) participants, who were classified into mild and moderate groups. Neuropsychological tests were carried out using the AD Assessment Scale-cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and World Health Organization University of California-Los Angeles, Auditory Verbal Learning Test (WHO-UCLA AVLT) before, immediately after, and 6 weeks after the intervention. In this work, data from 30 AD patients revealed that there was no obvious interaction effect of time-by-group. The ADAS-cog, MMSE and WHO-UCLA AVLT score in the rTMS group was significantly improved compared with baselines at 6 weeks after treatment (all p
- Published
- 2016
164. Improving Accuracy of Event-Related Potentials Classification by Channel Selection Using Independent Component Analysis and Least Square Methods
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Wenxuan Li, Wei Li, and Mengfan Li
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Computer science ,business.industry ,Individual difference ,Pattern recognition ,02 engineering and technology ,Independent component analysis ,03 medical and health sciences ,0302 clinical medicine ,Amplitude ,Event-related potential ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Selection method ,Artificial intelligence ,Combination method ,business ,030217 neurology & neurosurgery ,Selection (genetic algorithm) ,Communication channel - Abstract
This paper proposes a method for achieving a high performance of N200 and P300 classification by applying independent component analysis to select the channels, which deliver brain signals with large N200 and P300 potentials and small artifacts. In this study, the authors find out the relationship between the highest accuracy and the weights of the independent components and use this relationship to predict the optimal channels of each individual subject. They compare five channel selection methods: the ICA-based method and the curve-fitting-based method proposed in this paper, the amplitude-based method, the experiential optimal 8 channel combination and all 30 channel combination methods. The comparative studies show that the ICA-based method achieves an average accuracy of 99.3% across four subjects, which is superior to the other four methods.
- Published
- 2016
165. Innovative green product diffusion through word of mouth
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Xiaoya Han, Xuhuai He, Zhaofu Hong, and Mengfan Li
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050210 logistics & transportation ,021103 operations research ,05 social sciences ,0211 other engineering and technologies ,Transportation ,02 engineering and technology ,Market structure ,Green marketing ,Pricing strategies ,0502 economics and business ,Bertrand competition ,Sustainable design ,Stackelberg competition ,Business ,Product (category theory) ,Business and International Management ,Market share ,Industrial organization ,Civil and Structural Engineering - Abstract
Green products are gaining popularity because of their environmental friendliness compared with conventional products. This study examines a word-of-mouth (WOM) diffusion problem of a newly launched green product and investigates the effects of consumers’ environmental awareness (CEA). Analytical results show that CEA significantly affects green product diffusion in terms of firms’ pricing strategies and market shares. The market structure also has effects on diffusing a green product: the pricing strategies and environmental performance of diffusing a green product in a Bertrand competition market are different from those in a Stackelberg game market. When considering green-design decision, it is interesting to show that the green product’s price decreases with the increase of CEA, which is contrary to the pricing strategy without green design. From the numerical study of the CEA-featured WOM diffusion case, we find that CEA-featured WOM does not affect the pricing strategies of the green and conventional products, but does have a significant impact on the market shares of both products.
- Published
- 2020
166. A Dual Stimuli Approach Combined with Convolutional Neural Network to Improve Information Transfer Rate of Event-Related Potential-Based Brain-Computer Interface
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Wei Li, Huihui Zhou, Genshe Chen, Feng Duan, Jing Jin, and Mengfan Li
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Adult ,Male ,Information transfer ,Computer Networks and Communications ,Computer science ,Interface (computing) ,Models, Neurological ,02 engineering and technology ,Generation rate ,Convolutional neural network ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Event-related potential ,Neural Pathways ,0202 electrical engineering, electronic engineering, information engineering ,Humans ,Evoked Potentials ,Brain–computer interface ,business.industry ,Brain ,Electroencephalography ,Signal Processing, Computer-Assisted ,General Medicine ,DUAL (cognitive architecture) ,Brain-Computer Interfaces ,020201 artificial intelligence & image processing ,Female ,Perception ,business ,030217 neurology & neurosurgery ,Computer hardware ,Algorithms ,Photic Stimulation - Abstract
Increasing command generation rate of an event-related potential-based brain-robot system is challenging, because of limited information transfer rate of a brain-computer interface system. To improve the rate, we propose a dual stimuli approach that is flashing a robot image and is scanning another robot image simultaneously. Two kinds of event-related potentials, N200 and P300 potentials, evoked in this dual stimuli condition are decoded by a convolutional neural network. Compared with the traditional approaches, this proposed approach significantly improves the online information transfer rate from 23.0 or 17.8 to 39.1 bits/min at an accuracy of 91.7%. These results suggest that combining multiple types of stimuli to evoke distinguishable ERPs might be a promising direction to improve the command generation rate in the brain-computer interface.
- Published
- 2018
167. Pulsatilla Decoction and its bioactive component β-peltatin induce G2/M cell cycle arrest and apoptosis in pancreatic cancer
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Rong Wu, Zhichao Xi, Mengfan Liu, Hangui Ren, Rongchen Dai, Xue Jiang, Wan Najbah Nik Nabil, Yalin Wang, Jiling Feng, Qiong Chai, Qihan Dong, and Hongxi Xu
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Pulsatilla Decoction ,Pulsatilla ,β-peltatin ,Pancreatic cancer ,G2/M arrest ,Apoptosis ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Pancreatic cancer (PAC), a malignancy that is fatal and commonly diagnosed at a late stage. Despite considerable advancements in cancer treatment, the survival rate of PAC remains largely consistent for the past 60 years. The traditional Chinese medicine formula Pulsatilla Decoction (PD) has been clinically used to treat inflammatory diseases for millennia and recently as a supplementary anti-cancer treatment in China. However, the bioactive ingredients and mechanisms underlying its anti-cancer effect remains unclear. Methods The composition and quality control of PD were verified through analysis by high performance liquid chromatography. Cell viability was determined using Cell Counting Kit-8 assay. The cell cycle distribution was analyzed through PI staining and flow cytometry analysis, while apoptotic cells were measured by double staining with Annexin V-FITC and PI. We used immunoblotting to examine protein expressions. The in vivo effects of β-peltatin and podophyllotoxin were evaluated on a subcutaneously-xenografted BxPC-3 cell nude mice model. Results The current study demonstrated that PD markedly inhibited PAC cell proliferation and triggered their apoptosis. Four herbal PD formula was then disassembled into 15 combinations of herbal ingredients and a cytotoxicity assay showed that the Pulsatillae chinensis exerted the predominant anti-PAC effect. Further investigation indicated that β-peltatin was potently cytotoxic with IC50 of ~ 2 nM. β-peltatin initially arrested PAC cells at G2/M phase, followed by apoptosis induction. Animal study confirmed that β-peltatin significantly suppressed the growth of subcutaneously-implanted BxPC-3 cell xenografts. Importantly, compared to podophyllotoxin that is the parental isomer of β-peltatin but clinically obsoleted due to its severe toxicity, β-peltatin exhibited stronger anti-PAC effect and lower toxicity in mice. Conclusions Our results demonstrate that Pulsatillae chinensis and particularly its bioactive ingredient β-peltatin suppress PAC by triggering cell cycle arrest at G2/M phase and apoptosis.
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- 2023
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168. Synergistic Modulation of Sn-Based Perovskite Solar Cells with Crystallization and Interface Engineering
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Yunzhao Sun, Yaoyao Song, Mengfan Liu, and Huiyin Zhang
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Sn-based perovskite solar cells ,crystallization engineering ,interface engineering ,Sn2+ oxidation ,carrier extraction ,Organic chemistry ,QD241-441 - Abstract
A high-quality Sn-based perovskite absorption layer and effective carrier transport are the basis for high-performance Sn-based perovskite solar cells. The suppression of Sn2+ oxidation and rapid crystallization is the key to obtaining high-quality Sn-based perovskite film. And interface engineering is an effective strategy to enhance carrier extraction and transport. In this work, tin fluoride (SnF2) was introduced to the perovskite precursor solution, which can effectively modulate the crystallization and morphology of Sn-based perovskite layer. Furthermore, the hole-transporting layer of PEDOT:PSS was modified with CsI to enhance the hole extraction and transport. As a result, the fabricated inverted Sn-based perovskite solar cells demonstrated a power conversion efficiency of 7.53% with enhanced stability.
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- 2024
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169. Multiscale Spatiotemporal Dynamics of Drought within the Yellow River Basin (YRB): An Examination of Regional Variability and Trends
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Lei Jin, Shaodan Chen, and Mengfan Liu
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meteorological drought ,SPEI ,scPDSI ,Yellow River Basin (YRB) ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
Drought, as a recurring extreme climatic event, inflicts diverse impacts on ecological systems, agricultural productivity, water resources, and socio-economic progress globally. Discerning the drought patterns within the evolving environmental landscape of the Yellow River Basin (YRB) is imperative for enhancing regional drought management and fostering ecological conservation alongside high-quality development. This study utilizes meteorological drought indices, the Standardized Precipitation Evapotranspiration Index (SPEI) and the self-calibrating Palmer Drought Severity Index (scPDSI), for a detailed spatiotemporal analysis of drought conditions. It examines the effectiveness of these indices in the basin’s drought monitoring, offering a comprehensive insight into the area’s drought spatiotemporal dynamics. The findings demonstrate the following: (1) SPEI values exhibit distinct fluctuation patterns at varying temporal scales, with more pronounced fluctuations at shorter scales. Drought years identified via the 12-month SPEI time scale include 1965, 1966, 1969, 1972, 1986, 1997, 1999, 2001, and 2006. (2) A modified Mann–Kendall (MMK) trend test analysis of the scPDSI time series reveals a worrying trend of intensifying drought conditions within the basin. (3) Correlation analysis between SPEI and scPDSI across different time scales yields correlation coefficients of 0.35, 0.54, 0.69, 0.76, and 0.62, highlighting the most substantial correlation at an annual scale. Spatial correlation analysis conducted between SPEI and scPDSI across various scales reveals that, within diverse temporal ranges, the correlation peaks at a 12-month time scale, with subsequent prominence observed at 6 and 24 months. This observed pattern accentuates the applicability of scPDSI in the monitoring of medium- to long-term drought phenomena.
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- 2024
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170. Risks of benzalkonium chlorides as emerging contaminants in the environment and possible control strategies from the perspective of ecopharmacovigilance
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Mengfan Liao, Songyi Wei, Jinru Zhao, Jun Wang, and Guangquan Fan
- Subjects
Benzalkonium chlorides ,Disinfectants ,Emerging contaminants ,Ecopharmacovigilance ,Pharmaceutical emerging contaminants ,Environmental pollution ,TD172-193.5 ,Environmental sciences ,GE1-350 - Abstract
An unprecedented increase in the use of disinfection products triggered by the coronavirus disease 2019 (COVID-19) pandemic is resulting in aggravating environmental loads of disinfectants as emerging contaminants, which has been considered a cause for worldwide secondary disasters. This review analyzed the literature published in the last decade about occurrence, bioaccumulation, and possible environmental risks of benzalkonium chlorides (BKCs) as emerging contaminants. Results indicated that BKCs globally occurred in municipal wastewater, surface water, groundwater, reclaimed water, sludge, sediment, soil, roof runoff, and residential dust samples across 13 countries. The maximum residual levels of 30 mg/L and 421 μg/g were reported in water and solid environmental samples, respectively. Emerging evidences suggested possible bioaccumulation of BKCs in plants, even perhaps humans. Environmentally relevant concentrations of BKCs exert potential adverse impacts on aquatic and terrestrial species, including genotoxicity, respiratory toxicity, behavioural effects and neurotoxicity, endocrine disruption and reproductive impairment, phytotoxicity, etc. Given the intrinsic biocidal and preservative properties of disinfectants, the inductive effects of residual BKCs in environment in terms of resistance and imbalance of microorganisms have been paid special attention. Considering the similarities of disinfectants to pharmaceuticals, from the perspective of ecopharmacovigilance (EPV), a well-established strategy for pharmaceutical emerging contaminants, we use the control of BKC pollution as a case, and provide some recommendations for employing the EPV measures to manage environmental risks posed by disinfectant emerging contaminants.
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- 2023
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171. Neural network method for robot arm of service robot based on D-H model
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Zhiqiang Chen, Haixia Wang, Yanping Liu, Mengfan Li, Li Xujie, and Xiao Lu
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Service robot ,0209 industrial biotechnology ,Forward kinematics ,Robot kinematics ,Inverse kinematics ,Artificial neural network ,Computer science ,020208 electrical & electronic engineering ,02 engineering and technology ,Kinematics ,Computer Science::Robotics ,020901 industrial engineering & automation ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Manipulator ,Robotic arm - Abstract
In this paper, a radial basis function neural network was used to solve the robot arm with 4 DOF of a self-designed service robot. Firstly, the D-H model was established for the manipulator and the analysis of forward kinematics was carried out, and the transition relation between the connecting rod coordinates was obtained. Then, according to this relationship, the sample data from joint space to Cartesian space was trained. Finally, the radial basis function neural network was used to find the inverse solution of the manipulator, based on a large amount number of the sample data, and the mapping relationship from the Cartesian space to the joint space. The method was verified by MATLAB simulation, and it can be used to solve the inverse kinematics of robot arm. It met the design requirements of the service robot in a certain range of errors.
- Published
- 2017
172. Kinematics analysis and application of 5-DOF manipulator with special joint
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Mengfan Li, Qiong Pu, Jiaqiang Yan, Haixia Wang, Zhiqiang Chen, and Xiao Lu
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0209 industrial biotechnology ,Robot kinematics ,Forward kinematics ,Inverse kinematics ,Computer science ,Coordinate system ,02 engineering and technology ,Kinematics ,Computer Science::Robotics ,020303 mechanical engineering & transports ,020901 industrial engineering & automation ,Transformation (function) ,0203 mechanical engineering ,Control theory ,Manipulator ,Robotic arm - Abstract
An improved method based on the D-H method is proposed for a 5-DOF manipulator with special structure which is difficult to establish joint transformation by using normal D-H method. The forward kinematics of this manipulator with special structure is established by adding virtual joint. The method is suitable for manipulators with rotating joints, and the coordinate transformation must be achieved by transform along the Z axis. The process of inverse kinematics of the manipulator is analyzed. The conditions for the existence of inverse solution and the number of inverse solutions are also analyzed. Finally, the simulation of the proposed scheme is carried out to verify its correctness. And it has been applied to the physical mechanical arm.
- Published
- 2017
173. Path planning of mobile robot based on improved genetic algorithm
- Author
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Mengfan Li, Erkui Chen, Zhiqiang Chen, Luan Zhou, Qianqian Shi, and Meihua Wu
- Subjects
0209 industrial biotechnology ,education.field_of_study ,Population ,Mobile robot ,02 engineering and technology ,Random search ,020901 industrial engineering & automation ,Genetic algorithm ,0202 electrical engineering, electronic engineering, information engineering ,Robot ,020201 artificial intelligence & image processing ,Motion planning ,education ,Algorithm ,Coding (social sciences) ,Premature convergence - Abstract
In view of the shortcomings of the previous genetic algorithm in solving the problem of path planning of robot, this paper has improved it on the basis of the traditional genetic algorithm. The environment model is built by the grids and the fixed length serial number coding is used to encode. The random search method and the ascending order method are combined to generate the initial population. The preferred operator is introduced into the selection operator and this paper proposes a new adaptive adjustment formula which can automatically adjust the cross probability and the mutation probability on the basis of adaptive function value, which purpose is to avoid premature convergence. We use MATLAB to do simulation experiments. The result shows that this method make the path planning of robot more rapid and effective.
- Published
- 2017
174. Path planning of mobile robot based on genetic algorithm and gene rearrangement
- Author
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Zhiqiang Chen, Mengfan Li, Meihua Wu, Pengliang Hou, Chuanjiang Wang, and Xiao Lu
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0209 industrial biotechnology ,Mathematical optimization ,Computer science ,Mobile robot ,02 engineering and technology ,Gene rearrangement ,Collision ,Computer Science::Robotics ,020901 industrial engineering & automation ,Path (graph theory) ,Genetic algorithm ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Motion planning ,Quadratic programming ,Rotation (mathematics) - Abstract
In this paper, a mobile robot path planning algorithm based on the rearrangement of gene is proposed for genetic algorithm and applied to solve the problem of mobile robot path planning. Firstly, it needs to build the robot path with the multi-plane model, and the genetic algorithm is used to search the optimal or sub optimal path. Then, with a new algorithm for the route of quadratic optimization, making the large rotation angle of optimization as a smooth path close to the flat angle under the premise of guarantee without intersecting any obstacles. The simulation results show that the algorithm combined with the classical genetic algorithm is better than the basic genetic algorithm, which can not only reduce the complexity of the genetic algorithm but also shorten the path length to obtain the relatively optimal path without collision.
- Published
- 2017
175. Progress in EEG-Based Brain Robot Interaction Systems
- Author
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Mengfan Li, Bin Xian, Ming Zeng, Wei Li, Linwei Niu, Xiaoqian Mao, and Genshe Chen
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comic_strips ,General Computer Science ,Computer science ,General Mathematics ,0206 medical engineering ,Feature extraction ,02 engineering and technology ,Review Article ,lcsh:Computer applications to medicine. Medical informatics ,lcsh:RC321-571 ,Feedback ,03 medical and health sciences ,User-Computer Interface ,0302 clinical medicine ,Animals ,Humans ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Brain–computer interface ,business.industry ,General Neuroscience ,Electroencephalography ,General Medicine ,Robotics ,020601 biomedical engineering ,Brain Waves ,Robot control ,comic_strips.comic_strip ,Asynchronous communication ,Feature (computer vision) ,Brain-Computer Interfaces ,lcsh:R858-859.7 ,Robot ,Artificial intelligence ,business ,Brainwaves ,030217 neurology & neurosurgery ,Humanoid robot - Abstract
The most popular noninvasive Brain Robot Interaction (BRI) technology uses the electroencephalogram- (EEG-) based Brain Computer Interface (BCI), to serve as an additional communication channel, for robot control via brainwaves. This technology is promising for elderly or disabled patient assistance with daily life. The key issue of a BRI system is to identify human mental activities, by decoding brainwaves, acquired with an EEG device. Compared with other BCI applications, such as word speller, the development of these applications may be more challenging since control of robot systems via brainwaves must consider surrounding environment feedback in real-time, robot mechanical kinematics, and dynamics, as well as robot control architecture and behavior. This article reviews the major techniques needed for developing BRI systems. In this review article, we first briefly introduce the background and development of mind-controlled robot technologies. Second, we discuss the EEG-based brain signal models with respect to generating principles, evoking mechanisms, and experimental paradigms. Subsequently, we review in detail commonly used methods for decoding brain signals, namely, preprocessing, feature extraction, and feature classification, and summarize several typical application examples. Next, we describe a few BRI applications, including wheelchairs, manipulators, drones, and humanoid robots with respect to synchronous and asynchronous BCI-based techniques. Finally, we address some existing problems and challenges with future BRI techniques.
- Published
- 2017
176. Innovation Design in Personal Center Interface of Mobile Application
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Yuwei Fan, Han Xu, Di Zhu, Xin Xin, Haozhi Wang, Wei Zhou, Weizheng Ma, and Mengfan Li
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Consumption (economics) ,Multimedia ,Mobile internet ,Interface (Java) ,business.industry ,Computer science ,media_common.quotation_subject ,Internet privacy ,Chinese society ,computer.software_genre ,Payment ,Innovation design ,Key (cryptography) ,Center (algebra and category theory) ,business ,computer ,media_common - Abstract
Nowadays, Mobile Internet has changed the Chinese shop mostly. The appearance of e-commerce mobile applications greatly overthrows the consumption structures and patterns in Chinese society. Merchandises consumers could only buy at malls before; they can now get them by simply touching the screen, and then receive at next day. Shopping efficiency has been enhanced significantly. Personal Center page, where viewing and tracking orders, payment and other acts needed to be done, plays a key role in mobile applications of e-commerce. So far, however, far too little attention has been paid to Personal Center pages. They are complex, short of ideas, and have too many levels with unfriendly interface. It is hard to give users good experience. Based on the Personal Center of the Pinzhi 365 mobile application, this innovation design, by the analysis of similar competing products, enhanced their accessibility, efficiency, memorability and friendliness, which create a model of innovation design in Personal Center interface.
- Published
- 2017
177. α4β7 Integrin (LPAM-1) is Upregulated at Atherosclerotic Lesions and is Involved in Atherosclerosis Progression
- Author
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Xiao-Ping Zhang, Yongfa Wu, Sili Zhou, Kangkang Zhi, Maoquan Li, Zhiwei Gao, Lefeng Qu, Jun Bai, and Mengfan Li
- Subjects
MAPK/ERK pathway ,Apolipoprotein E ,Integrins ,Integrin beta Chains ,Physiology ,Phagocytosis ,Integrin ,Blotting, Western ,Vascular Cell Adhesion Molecule-1 ,Diet, High-Fat ,lcsh:Physiology ,Focal adhesion ,lcsh:Biochemistry ,Apolipoproteins E ,Mucoproteins ,Addressin ,Animals ,lcsh:QD415-436 ,Phosphorylation ,Extracellular Signal-Regulated MAP Kinases ,α4β7 integrin ,ApoE-/- mice ,Mice, Knockout ,biology ,lcsh:QP1-981 ,Chemistry ,Cell adhesion molecule ,Atherosclerosis ,Plaque, Atherosclerotic ,Up-Regulation ,Lipoproteins, LDL ,Mice, Inbred C57BL ,Microscopy, Fluorescence ,Peripheral blood lymphocyte ,Focal Adhesion Protein-Tyrosine Kinases ,Immunology ,biology.protein ,Cancer research ,Disease Progression ,Macrophages, Peritoneal ,lipids (amino acids, peptides, and proteins) ,Cell Adhesion Molecules - Abstract
Background/Aims: Integrin activation and lymphocyte migration to the vascular intima is a key event in early atherosclerosis. α4β7 integrin (LPAM-1) and its ligand, mucosal addressin cell adhesion molecule (MAdCAM-1) are known to play an important role in homing of activated lymphocytes to gut-associated lymphoid tissues. However, it is unclear whether α4β7 integrin is involved in the pathogenesis of atherosclerosis. Methods: The expressions of α4β7 integrin and its ligands in atherosclerosis plaques from 12 week high fat diet (HFD) fed ApoE-/- and C57BL/6 mice were examined using immunofluorescent and immunohistochemical assays, respectively. We also generated ApoE/β7 double deficient mice and compared atherosclerotic lesion development in β7+/+ApoE-/- and β7-/-ApoE-/- mice that were fed with HFD for 12 weeks. Results: We found an upregulation of α4β7 integrin and its ligands VCAM-1 and MAdCAM-1 at atherosclerosis plaques in Apolipoprotein E deficient (ApoE-/-) mice fed with HFD for 12 weeks. Over the 12 week HFD period, peripheral blood lymphocyte (PBL) expression of α4β7 integrin increased in parallel with aortic lesion size. A removal of α4β7 integrin by genetic deletion of the β7 chain in the ApoE-/- mouse resulted in a markedly decreased 12 week-HFD atherosclerotic plaque area. β7-/- ApoE-/- macrophages showed reduced acetylated and native LDL uptake and phagocytic activity, revealing possible roles for α4β7 at two distinct stages of macrophage dysfunction during atherogenesis. Finally, a reduced activity of integrin downstream signalling components focal adhesion kinase (FAK) and MAPK/ERK1/2 in macrophage indicates their possible engagement during α4β7 integrin signalling in atherosclerosis. Conclusions: Together our results reveal a critical role of α4β7 in diet-induced atherosclerosis in mouse.
- Published
- 2014
178. Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis
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Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi, and Hongxi Xu
- Subjects
Tumour cell dormancy ,Osteoclasts ,Osteoblasts ,Bone marrow niche ,Bone metastasis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour cells, DTCs). The bone marrow seems to be a particularly dormancy-inducing environment for DTCs, yet the mechanisms of dormancy initiation, reactivation, and interaction within the bone marrow have to be elucidated. Intriguingly, some evidence has suggested that dormancy is a reversible state that is switched ‘on’ or ‘off’ depending on the presence of various bone marrow resident cells, particularly osteoclasts and osteoblasts. It has become clear that these two cells contribute to regulating dormant tumour cells in bone both directly (interaction) and indirectly (secreted factors). The involved mechanisms include TGFβ signalling, the Wnt signalling axis, the Notch2 pathway, etc. There is no detailed review that specifically focuses on ascertaining the dynamic interactions between tumour cell dormancy and bone remodelling. In addition, we highlighted the roles of inflammatory cytokines during this ‘cell-to-cell’ communication. We also discussed the potential clinical relevance of remodelling the bone marrow niche in controlling dormant tumour cells. Understanding the unique role of osteoclasts and osteoblasts in regulating tumour dormancy in bone marrow will provide new insight into preventing and treating tumour bone metastasis.
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- 2022
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- View/download PDF
179. Education-oriented portable brain-controlled robot system
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Jing Zhao, Wei Li, Xiaoqiang Mao, Mengfan Li, Zhengping Wu, Danyang Zhi, and Meifang Ma
- Subjects
Ubiquitous robot ,Personal robot ,Signal processing ,Engineering ,business.industry ,Mobile robot ,Robot learning ,law.invention ,Robot control ,Bluetooth ,law ,Human–computer interaction ,Embedded system ,Robot ,business - Abstract
In this paper, we develop an education-oriented portable brain-controlled robot system, consisting of a multi-parameter bioelectric signal acquisition device and a Lego NXT Mindstorms robot. The education-oriented portable brain-controlled robot system is only 45 cm3 in volume and weighs 70g. The signal acquisition section wirelessly acquires brain signals and the control section remotely navigates a Lego robot via brainwaves through a Bluetooth. Teenagers may use the low-cost brain-controlled robot to enjoy the pleasure of learning, to inspire their innovative ability and creativity, and to raise their mental concentration. Moreover, the proposed brain-controlled robot system might be used to improve the quality of adolescent education and autism recovery. The system modules include the brain signal acquisition, signal processing, and the robot control, which are developed in LabVIEW-based programming environment and easy to be expanded and upgraded. The comparative study of the education-oriented system and Cerebot equipped with the high precision Cerebus system widely used in laboratory research shows that the low-cost system delivers comparable accuracy for the robot control. An operation task is presented to train users' attentions and concentrations.
- Published
- 2015
180. Lamin B1 Tethers to Chromatin and Organizes Its High-Order Structure
- Author
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Ruifeng Li, Shipeng Shao, Mengfan Li, Boxin Xue, Lei Chang, Yingping Hou, Yujie Sun, and Cheng Li
- Subjects
Chemistry ,Biophysics ,High order ,Lamin ,Chromatin ,Cell biology - Published
- 2018
181. The effect of physical exercise on the anxiety of college students in the post-pandemic era: The mediating role of social support and proactive personality
- Author
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Mengfan Liu and Bo Shi
- Subjects
post-pandemic era ,physical exercise ,anxiety of college students ,social support ,proactive personality ,Psychology ,BF1-990 - Abstract
In order to study the current situation of the anxiety of college students in the post-pandemic era and the effect of physical exercise on anxiety, this study explores the influence of social support and proactive personality as mediating variables on the anxiety of college students from the perspective of physical exercise. Firstly, anxiety symptoms and anxious emotions are defined. Secondly, a questionnaire survey is conducted for a well-known university in a certain city, and different questionnaire scales are developed from the physical exercise, anxiety, social support, and proactive personality assessment of college students. Finally, the results of the survey are statistically analyzed to explore the relieving effect of physical exercise on anxiety. The results reveal that there is a significant gender difference in the level of physical exercise, and the amount of physical exercise of the male students is generally higher than that of female students. In addition, the intensity, time, and frequency of exercise of male students are more than that of female students, but there is no obvious difference between them and whether they were only children. Physical exercise habits, social support, proactive personality traits, and anxiety of college students have a significant correlation. Through the analysis of the chain mediation effect, Ind2 (0.0140) is the largest coefficient among the three paths, indicating that the path of influencing social support through physical exercise habits, followed by affecting proactive personality traits, and then impacting anxiety has the strongest explanatory force. According to the results, strategies to relieve the anxiety of college students are given. This study can provide a reference for the research on the methods to alleviate their anxiety under the influence of the epidemic.
- Published
- 2023
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182. SSVEP-based Experimental Procedure for Brain-Robot Interaction with Humanoid Robots
- Author
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Jing Zhao, Mengfan Li, Xiaoqian Mao, and Wei Li
- Subjects
Digital signal processor ,OpenVibe ,General Immunology and Microbiology ,business.industry ,Computer science ,General Chemical Engineering ,General Neuroscience ,Video feedback ,General Biochemistry, Genetics and Molecular Biology ,Engineering ,Software ,Human–computer interaction ,Robot ,User interface ,business ,MATLAB ,Neuroscience ,computer ,Humanoid robot ,computer.programming_language - Abstract
Brain-Robot Interaction (BRI), which provides an innovative communication pathway between human and a robotic device via brain signals, is prospective in helping the disabled in their daily lives. The overall goal of our method is to establish an SSVEP-based experimental procedure by integrating multiple software programs, such as OpenViBE, Choregraph, and Central software as well as user developed programs written in C++ and MATLAB, to enable the study of brain-robot interaction with humanoid robots. This is achieved by first placing EEG electrodes on a human subject to measure the brain responses through an EEG data acquisition system. A user interface is used to elicit SSVEP responses and to display video feedback in the closed-loop control experiments. The second step is to record the EEG signals of first-time subjects, to analyze their SSVEP features offline, and to train the classifier for each subject. Next, the Online Signal Processor and the Robot Controller are configured for the online control of a humanoid robot. As the final step, the subject completes three specific closed-loop control experiments within different environments to evaluate the brain-robot interaction performance. The advantage of this approach is its reliability and flexibility because it is developed by integrating multiple software programs. The results show that using this approach, the subject is capable of interacting with the humanoid robot via brain signals. This allows the mind-controlled humanoid robot to perform typical tasks that are popular in robotic research and are helpful in assisting the disabled.
- Published
- 2015
183. Independent component analysis-based channel selection to achieve high performance of N200 and P300 classification
- Author
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Wei Li, Wenxuan Li, and Mengfan Li
- Subjects
business.industry ,Computer science ,Individual difference ,Pattern recognition ,Artificial intelligence ,business ,Independent component analysis ,Selection (genetic algorithm) ,Communication channel - Abstract
This paper proposes a method for achieving a high performance of N200 and P300 classification, which applies independent component analysis (ICA) to select the channels whose brain signals contain large N200 and P300 potentials and small artifacts as the optimal channels to extract the features. The study results show that our method achieves an average accuracy of 99.3% over 4 subjects.
- Published
- 2015
184. Comparative Study of SSVEP- and P300-Based Models for the Telepresence Control of Humanoid Robots
- Author
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Wei Li, Jing Zhao, and Mengfan Li
- Subjects
Adult ,Male ,Visual perception ,Computer science ,lcsh:Medicine ,Young Adult ,Brain Robot Interaction ,Humans ,Computer vision ,P300 ,lcsh:Science ,Humanoid Robots ,SSVEP ,Multidisciplinary ,business.industry ,lcsh:R ,Brain ,Reproducibility of Results ,Robotics ,Electroencephalography ,Signal Processing, Computer-Assisted ,Event-Related Potentials, P300 ,Brain-Computer Interfaces ,Robot ,Evoked Potentials, Visual ,lcsh:Q ,Female ,Artificial intelligence ,Behavior-based robotics ,business ,Humanoid robot ,Algorithms ,Research Article - Abstract
In this paper, we evaluate the control performance of SSVEP (steady-state visual evoked potential)- and P300-based models using Cerebot – a mind-controlled humanoid robot platform. Seven subjects with diverse experience participated in experiments concerning the open-loop and closed-loop control of a humanoid robot via brain signals. The visual stimuli of both the SSVEP- and P300- based models were implemented on a LCD computer monitor with a refresh frequency of 60 Hz. Considering the operation safety, we set the classification accuracy of a model over 90.0 % as the most important mandatory for the telepresence control of the humanoid robot. The open-loop experiments demonstrated that the SSVEP model with at most four stimulus targets achieved the average accurate rate about 90 %, whereas the P300 model with the six or more stimulus targets under five repetitions per trial was able to achieve the accurate rates over 90.0 %. Therefore, the four SSVEP stimuli were used to control four types of robot behavior; while the six P300 stimuli were chosen to control six types of robot behavior. Both of the 4-class SSVEP and 6-class P300 models achieved the average success rates of 90.3 % and 91.3 %, the average response times of 3.65 s and 6.6 s, and the average information transfer rates (ITR) of 24.7 bits/min 18.8 bits/min, respectively. The closed-loop experiments addressed the telepresence control of the robot; the objective was to cause the robot to walk along a white lane marked in an office environment using live video feedback. Comparative studies reveal that the SSVEP model yielded faster response to the subject’s mental activity with less reliance on channel selection, whereas the P300 model was found to be suitable for more classifiable targets and required less training. To conclude, we discuss the existing SSVEP and P300 models for the control of humanoid robots, including the models proposed in this paper.
- Published
- 2015
185. Control of humanoid robot via motion-onset visual evoked potentials
- Author
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Mengfan Li, Wei Li, and Jing Zhao
- Subjects
Computer science ,mind-controlled humanoid robot ,Cognitive Neuroscience ,Control (management) ,Neuroscience (miscellaneous) ,brain robot interaction ,Task (project management) ,lcsh:RC321-571 ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Component (UML) ,Computer vision ,Original Research Article ,Evoked potential ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Simulation ,visual feedback ,business.industry ,humanoid robot behavior ,Object (computer science) ,N200 potentials ,Obstacle ,Robot ,Artificial intelligence ,business ,Humanoid robot ,Neuroscience - Abstract
This paper investigates controlling humanoid robot behavior via motion-onset specific N200 potentials. In this study, N200 potentials are induced by moving a blue bar through robot images intuitively representing robot behaviors to be controlled with mind. We present the individual impact of each subject on N200 potentials and discuss how to deal with individuality to obtain a high accuracy. The study results document the off-line average accuracy of 93% for hitting targets across over five subjects, so we use this major component of the motion-onset visual evoked potential (mVEP) to code people's mental activities and to perform two types of on-line operation tasks: navigating a humanoid robot in an office environment with an obstacle and picking-up an object. We discuss the factors that affect the on-line control success rate and the total time for completing an on-line operation task.
- Published
- 2015
186. The Principle of Steam Explosion Technology and Its Application in Food Processing By-Products
- Author
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Changrong Wang, Mengfan Lin, Qingyu Yang, Chenying Fu, and Zebin Guo
- Subjects
steam explosion ,principle ,application ,Chemical technology ,TP1-1185 - Abstract
Steam explosion technology is an emerging pretreatment method that has shown great promise for food processing due to its ability to efficiently destroy the natural barrier structure of materials. This narrative review summarizes the principle of steam explosion technology, its similarities and differences with traditional screw extrusion technology, and the factors that affect the technology. In addition, we reviewed the applications in food processing by-products in recent years. The results of the current study indicate that moderate steam explosion treatment can improve the quality and extraction rate of the target products. Finally, we provided an outlook on the development of steam explosion technology with a reference for a wider application of this technology in the food processing field.
- Published
- 2023
- Full Text
- View/download PDF
187. Advances in therapeutic agents targeting quiescent cancer cells
- Author
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Wan Najbah Nik Nabil, Zhichao Xi, Mengfan Liu, Yang Li, Mu Yao, Tao Liu, Qihan Dong, and Hongxi Xu
- Subjects
quiescence ,dormancy ,neoplasm ,mechanism ,therapeutic agent ,Pharmacy and materia medica ,RS1-441 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Quiescent cancer cells (QCCs) reversibly reside in G0 phase, thus allowing them to survive chemotherapy and radiotherapy, which generally target proliferating cells. Surviving QCCs may re-proliferate, and consequently result in cancer progression, recurrence, and metastasis. Therefore, understanding the key players governing QCC survival and activation is crucial for developing QCC-targeting agents. This review presents an overview of (1) the mechanisms underlying the regulation of QCC status and (2) recent advances in the development of QCC-targeting therapeutic agents and their underlying mechanisms. The development of effective therapeutic modalities that target QCCs may enable new cancer treatments to prevent cancer progression and recurrence.
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- 2022
- Full Text
- View/download PDF
188. Training method and system for stress management and mental health care of managers based on deep learning
- Author
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Mengfan Liu, Runkai Jiao, and Qing Nian
- Subjects
management workers ,stress management ,mental health counseling ,work pressure ,work task ,Biotechnology ,TP248.13-248.65 ,Mathematics ,QA1-939 - Abstract
In recent years, with the rapid development of the economy, in order to stabilize in the market and expand their own business, various companies in the form of various indicators, tangible or intangible to improve the management of the work of workers, speed up the pace of work, take up more work time. This article studies its relationship with stress management from the perspective of psychological capital, in order to achieve prior control of work stress from the perspective of individual positive psychological capital, and provide a new perspective for work stress management in the field of human resource management, and at the same time Enterprises and colleges and universities improve the psychological capital of employees and provide new management models. The unreasonable distribution of work even affects the daily life of management workers and aggravates the working pressure of company management workers. The training process of deep learning is actually the process of repeated forward and reverse calculations of the deep neural network based on the provided data. This process can actually be abstracted, and the deep learning framework is designed to accomplish this task. The existence of a deep learning framework allows users not to fully understand the principles and training process of deep neural networks, but can effectively train the models they want. A long time of high mental state tension leads to a variety of physical and psychological discomfort. If the pressure cannot be alleviated and released, this article extends the health collection equipment of the deep learning to households, continuously records the health status of residents through the mobile Internet, and uses the information resources of the regional residents' health file platform to provide residents with health status evaluation, management and guidance, health care consultation, education and education. A series of personal health management services such as health risk factor assessment. The positive emotion index of managers increased from 18 to 27, and the negative emotion index decreased from 29 to 13. The positive emotion was significantly more than the negative emotion, and the emotional situation was improved.
- Published
- 2022
- Full Text
- View/download PDF
189. SSVEP-based hierarchical architecture for control of a humanoid robot with mind
- Author
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Jing Zhao, Genshe Chen, Wei Li, Mengfan Li, and Qing-Hao Meng
- Subjects
Ubiquitous robot ,Engineering ,Robot kinematics ,Personal robot ,Social robot ,business.industry ,Mobile robot ,Robot learning ,Robot control ,Human–computer interaction ,Computer vision ,Artificial intelligence ,business ,Humanoid robot - Abstract
In this paper, we present an SSVEP-based hierarchical architecture for control of a humanoid robot with mind, consisting of five-layer decisions from robot state level to implementation level. This architecture is able to control a variety of humanoid robot behaviors at different levels to perform a complex task. We implement this hierarchical architecture on our Cerebot platform and test this control architecture in a multi-task experiment. We compare its control performance with the one achieved using manual control by an experienced operator. The results show that the architecture with coordinating multi-layer decisions and fusing human and robot actions is a good way to solve the issue of the limited information transfer rate (ITR) in mind-controlled humanoid robot system using current EEG-based BCI technology.
- Published
- 2014
190. Control of a humanoid robot via N200 potentials
- Author
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Qing-Hao Meng, Mengfan Li, Genshe Chen, Wei Li, and Jing Zhao
- Subjects
Computer science ,business.industry ,Feature vector ,Feature extraction ,Computer vision ,Artificial intelligence ,Evoked potential ,business ,Humanoid robot ,Visualization - Abstract
In this paper, we present a N200 model for control of a humanoid robot with mind. N200 is a major component of the motion visual evoked potential (mVEP) which can be used to detect the subject's intention. In order to acquire N200, we design a visual stimulus interface in which the activation of a stimulus is a bar scanning above the image of a humanoid robot behavior. By analyzing brain signals induced by this kind of stimulus and calculating some system indexes, the results of this study demonstrate that the designed interface can induce prominent N200 potentials, and another component P300 induced by this experiment can be considered as another characteristic of the feature vector to contribute to the classification. To our best knowledge, this paper would be the first report on an application of N200 model to control a humanoid robot with visual feedback in real time.
- Published
- 2014
191. A P300 Model for Cerebot – A Mind-Controlled Humanoid Robot
- Author
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Qing-Hao Meng, Genshe Chen, Wei Li, Mengfan Li, Ming Zeng, and Jing Zhao
- Subjects
OpenVibe ,Computer science ,business.industry ,Computer vision ,Mind control ,Artificial intelligence ,Topographical distribution ,business ,Humanoid robot - Abstract
In this paper, we present a P300 model for control of Cerebot – a mind-controlled humanoid robot, including a procedure of acquiring P300 signals, topographical distribution analysis of P300 signals, and a classification approach to identifying subjects’ mental activities regarding robot-walking behavior.
- Published
- 2014
192. An OpenViBE-based brainwave control system for Cerebot
- Author
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Qing-Hao Meng, Wei Li, Jing Zhao, Genshe Chen, Fuchun Sun, and Mengfan Li
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OpenVibe ,Computer science ,business.industry ,OpenGL ,Mobile robot ,Data acquisition ,Software ,Control system ,business ,MATLAB ,computer ,Humanoid robot ,Simulation ,computer.programming_language - Abstract
In this paper, we develop a brainwave-based control system for Cerebot, consisting of a humanoid robot and a Cerebus™ Data Acquisition System up to 128 channels. Under the OpenViBE programming environment, the control system integrates OpenGL, OpenCV, WEBOTS, Choregraph, Central software, and user-developed programs in C++ and Matlab. The proposed system is easy to be expanded or upgraded. Firstly, we describe the system structures for off-line analysis of acquired neural signals and for on-line control of a humanoid robot via brainwaves. Secondly, we discuss how to use the toolboxes provided with the OpenViBE environment to design three types of brainwave-based models: SSVEPs, P300s, and mu/beta rhythms. Finally, we use the Cerebot platform to investigate the three models by controlling four robot-walking behaviors: turning right, turning left, walking forward, and walking backward.
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- 2013
193. A study of the relationship between wetland vegetation communities and water regimes using a combined remote sensing and hydraulic modeling approach
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Zhiqiang, Tan, primary, Qi, Zhang, primary, Mengfan, Li, primary, Yunliang, Li, primary, Xiuli, Xu, primary, and Jiahu, Jiang, primary
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- 2016
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194. Screening and testing methods of short-wave infrared area array detectors for synchronous monitoring atmospheric corrector.
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Yang, Li, Mengfan, Li, Siqi, Liu, Ge, Gan, Jin, Hong, and Zhenwei, Qiu
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- 2023
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195. TLR4 signaling in the development of colitis-associated cancer and its possible interplay with microRNA-155
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Jie Guo, Mengfan Liao, and Jun Wang
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Toll like receptor 4 ,MicroRNA-155 ,Inflammatory bowel disease ,Colitis-associated cancer ,Positive feedback loop ,Medicine ,Cytology ,QH573-671 - Abstract
Abstract Ulcerative colitis (UC) has closely been associated with an increased risk of colorectal cancer. However, the exact mechanisms underlying colitis-associated cancer (CAC) development remain unclear. As a classic pattern-recognition receptor, Toll like receptor (TLR)4 is a canonical receptor for lipopolysaccharide of Gram-negative bacteria (including two CAC-associated pathogens Fusobacterium nucleatum and Salmonella), and functions as a key bridge molecule linking oncogenic infection to colonic inflammatory and malignant processes. Accumulating studies verified the overexpression of TLR4 in colitis and CAC, and the over-expressed TLR4 might promote colitis-associated tumorigenesis via facilitating cell proliferation, protecting malignant cells against apoptosis, accelerating invasion and metastasis, as well as contributing to the creation of tumor-favouring cellular microenvironment. In recent years, considerable attention has been focused on the regulation of TLR4 signaling in the context of colitis-associated tumorigenesis. MicroRNA (miR)-155 and TLR4 exhibited a similar dynamic expression change during CAC development and shared similar CAC-promoting properties. The available data demonstrated an interplay between TLR4 and miR-155 in the context of different disorders or cell lines. miR-155 could augment TLR4 signaling through targeting negative regulators SOCS1 and SHIP1; and TLR4 activation would induce miR-155 expression via transcriptional and post-transcriptional mechanisms. This possible TLR4-miR-155 positive feedback loop might result in the synergistic accelerating effect of TLR4 and miR-155 on CAC development. Video abstract
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- 2021
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196. Vaccination practices, knowledge and attitudes regarding COVID-19 vaccines among Chinese university students: a cross-sectional study from a comprehensive university in Wuhan
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Jun Wang, Dan Yan, Xinyi Hu, Mengfan Liao, and Songyi Wei
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Medicine - Abstract
Objective In China, a free national COVID-19 vaccination programme has been launched in spring 2021 and is ongoing across the country. This study aimed to preliminarily understand the current COVID-19 vaccination practices and the associated knowledge/attitude factors among Chinese university students.Design and setting A single-centre cross-sectional questionnaire-based study was conducted between 1 and 20 May 2021 among a convenience sample of Chinese university students recruited from a comprehensive university in Wuhan. A total of 359 valid questionnaires were obtained.Results Just 1 month after the commencement of the university vaccination process, 75% of responding students had received the COVID-19 vaccination. Students without experience of COVID-19 infection were more likely to get vaccinated than those who had been infected. Most (57%) received information about COVID-19 vaccination through official announcements released by the university, and 67% were vaccinated at vaccination place arranged by the university. An interesting finding is that, although the overall vaccine uptake rate was 75%, nearly one-third of vaccinees did not know or incorrectly stated the type of COVID-19 vaccines that they had received. Mean knowledge test score was 3.05 out of 6, suggesting poor knowledge regarding COVID-19 vaccines. The vaccinated showed more positive attitudes towards the importance of establishing herd immunity through the COVID-19 vaccination programme for pandemic control than the non-vaccinated did. ‘Effectiveness in preventing COVID-19’ was perceived by 76% respondents as the most important factor contributing to COVID-19 vaccination. A total of 76% were worried about safety-related issues, including ‘unknown long-term safety’, ‘vaccine allergy’ and ‘vaccine-caused COVID-19 infection’.Conclusions Data suggested a rapid and effective progress of the national COVID-19 vaccination programme in China among university students. Taking effective official actions, as well as enhancing the belief in vaccines’ effectiveness, might be necessary for the good implementation of COVID-19 vaccination programmes.
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- 2022
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197. Author Correction: Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways
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Yingchuan Li, Zhen Zeng, Yongmei Cao, Yujing Liu, Feng Ping, Mengfan Liang, Ying Xue, Caihua Xi, Ming Zhou, and Wei Jiang
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Medicine ,Science - Published
- 2022
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198. MicroRNA-98-5p Inhibits Cell Proliferation and Induces Cell Apoptosis in Hepatocellular Carcinoma via Targeting IGF2BP1.
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Tinghui Jiang, Mengfan Li, Qiuyin Li, Zhiqiang Guo, Xianjun Sun, Xufeng Zhang, Yan Liu, Wenyi Yao, and Ping Xiao
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MICRORNA ,LIVER cancer ,CELL proliferation ,APOPTOSIS ,DOWNREGULATION ,GENETIC overexpression - Abstract
Some microRNAs (miRs) have been demonstrated to play promoting or tumor-suppressing roles in the development and progression of hepatocellular carcinoma (HCC). However, the regulatory mechanism of miR-98-5p in HCC still remains largely unclear. In the present study, our data showed that miR-98-5p was significantly downregulated in 84 cases of HCC tissues compared to the matched adjacent nontumor tissues. In addition, downregulation of miR-98-5p was associated with tumor size, portal vein tumor embolus, node metastasis, and clinical stage in HCC. HCC patients with low expression of miR-98-5p showed a shorter survival time compared with those with high miR-98-5p levels. Moreover, the expression of miR-98-5p was also reduced in HCC cell lines (HepG2, Hep3B, LM3, and SMCC7721) compared to the normal liver cell line THLE-3. Overexpression of miR-98-5p significantly decreased LM3 cell growth by inducing cell cycle arrest at the G1 stage and cell apoptosis. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) was then identified as a novel target gene of miR-98-5p, and its protein expression was negatively regulated by miR-98-5p in LM3 cells. Overexpression of IGF2BP1 eliminated the effects of miR-98-5p overexpression on the proliferation, cell cycle, and apoptosis of LM3 cells. Finally, we found that IGF2BP1 was upregulated in HCC, and its expression was negatively correlated to miR-98-5p levels. In summary, we demonstrate that miR-98-5p could inhibit HCC cell proliferation while inducing cell apoptosis, partly at least, via inhibition of its target gene IGF2BP1, and we suggest that miR-98-5p may become a promising therapeutic candidate for HCC treatment. [ABSTRACT FROM AUTHOR]
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- 2017
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199. Nitrate-Nitrogen Adsorption Characteristics and Mechanisms of Various Garden Waste Biochars
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Jingjing Yao, Zhiyi Wang, Mengfan Liu, Bing Bai, and Chengliang Zhang
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nitrate-nitrogen ,garden waste ,biochar ,pyrolysis temperature ,NO3−–N removal efficiency ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Nitrate-nitrogen (NO3−–N) removal and garden waste disposal are critical concerns in urban environmental protection. In this study, biochars were produced by pyrolyzing various garden waste materials, including grass clippings (GC), Rosa chinensis Jacq. branches (RC), Prunus persica branches (PP), Armeniaca vulgaris Lam. branches (AV), Morus alba Linn. sp. branches (MA), Platycladus orientalis (L.) Franco branches (PO), Pinus tabuliformis Carrière branches (PT), and Sophorajaponica Linn. branches (SL) at three different temperatures (300 °C, 500 °C, and 700 °C). These biochars, labeled as GC300, GC500, GC700, and so on., were then used to adsorb NO3−–N under various conditions, such as initial pH value, contact time, initial NO3−–N concentration, and biochar dosage. Kinetic data were analyzed by pseudo-first-order and pseudo-second-order kinetic models. The equilibrium adsorption data were evaluated by Langmuir, Freundlich, Temkin and Dubinin–Radushkevich models. The results revealed that the biochar yields varied between 14.43% (PT700) and 47.09% (AV300) and were significantly influenced by the type of garden waste and decreased with increasing pyrolysis temperature, while the pH and ash content showed an opposite trend (p < 0.05). The efficiency of NO3−–N removal was significantly influenced by the type of feedstock, preparation process, and adsorption conditions. Higher pH values had a negative influence on NO3−–N adsorption, while longer contact time, higher initial concentration of NO3−–N, and increased biochar dosage positively affected NO3−–N adsorption. Most of the kinetic data were better fitted to the pseudo-second-order kinetic model (0.998 > R2 > 0.927). Positive b values obtained from the Temkin model indicated an exothermic process of NO3−–N adsorption. The Langmuir model provided better fits for more equilibrium adsorption data than the Freundlich model, with the maximum NO3−–N removal efficiency (62.11%) and adsorption capacity (1.339 mg·g−1) in PO700 under the conditions of pH = 2, biochar dosage = 50 mg·L−1, and a reaction time of 24 h. The outcomes of this study contribute valuable insights into garden waste disposal and NO3−–N removal from wastewater, providing a theoretical basis for sustainable environmental management practices.
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- 2023
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200. Protective Effect and Mechanisms of Eckol on Chronic Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice
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Mengfan Liao, Songyi Wei, Xianmin Hu, Juan Liu, and Jun Wang
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Eckol ,chronic ulcerative colitis ,inflammation ,apoptosis ,immunoregulation ,TLR4 pathway ,Biology (General) ,QH301-705.5 - Abstract
The use of functional foods and their bioactive components is receiving increasing attention as a complementary and alternative therapy for chronic ulcerative colitis (UC). This study explored the protective effect and mechanisms of Eckol, a seaweed-derived bioactive phlorotannin, on the dextran sodium sulfate (DSS)-induced chronic UC in mice. Eckol (0.5–1.0 mg/kg) reduced DSS-enhanced disease activity indexes, and alleviated the shortening of colon length and colonic tissue damage in chronic UC mice. The contents of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were significantly decreased, and the level of anti-inflammatory IL-10 was enhanced in the serum and colonic tissues collected from Eckol-treated mice compared with the DSS controls. Eckol administration significantly reduced the number of apoptotic cells and the expression of cleaved Caspase-3, and increased the B-cell lymphoma-2 (Bcl-2)/B-cell lymphoma-2- associated X (Bax) ratio in DSS-challenged colons. There were more cluster of differentiation (CD)11c+ dendritic cells and CD8+ T cells, and less CD4+ T cells infiltrated to inflamed colonic tissues in the Eckol-treated groups. Expression of colonic Toll-like receptor 4 (TLR4), nuclear factor kappa-B (NF-κB) p65, phosphorylated-signal transducer and activator of transcription (pSTAT)3 was significantly down-regulated by Eckol compared with the DSS-challenged group. In conclusion, our data suggest that Eckol appeared to be a potential functional food ingredient for protection against chronic UC. The anti-colitis mechanisms of Eckol might be attributed to the down-regulation of the TLR4/NF-κB/STAT3 pathway, inhibition of inflammation and apoptosis, as well as its immunoregulatory activity.
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- 2023
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