999 results on '"Megarbane, Bruno"'
Search Results
152. Extracorporeal life support in COVID‐19‐related acute respiratory distress syndrome: A EuroELSO international survey
- Author
-
Mang, Sebastian, Kalenka, Armin, Broman, Lars Mikael, Supady, Alexander, Swol, Justyna, Danziger, Guy, Becker, André, Hörsch, Sabrina, Mertke, Thilo, Kaiser, Ralf, Bracht, Hendrik, Zotzmann, Viviane, Seiler, Frederik, Bals, Robert, Taccone, Fabio Silvio, Moerer, Onnen, Lorusso, Roberto, Bělohlávek, Jan, Muellenbach, Ralf, Lepper, Philipp, Barrett, Nicholas, Duerschmied, Daniel, Fan, Eddy, Fichtner, Falk, Haake, Hendrik, Langer, Frank, Mutlak, Haitham, Kredel, Markus, Müller, Thomas, Protti, Alessandro, Raddatz, Alexander, Spangenberg, Tobias, Staudacher, Dawid, Wehrfritz, Holger, Wengenmayer, Tobias, Westheider, Arne, Dang Van, Simon, Daubin, Cedric, Gaudard, Philippe, Godet, Thomas, Guinot, Pierre‐Grégoire, Le Guennec, Loïc, Megarbane, Bruno, Mercat, Alain, Sonneville, Romain, Zogheib, Elie, Pham, Tai, Winiszewski, Hadrien, Schellongowski, Peter, Staudinger, Thomas, Wiedemann, Dominik, Velik‐Salchner, Corinna, Joannidis, Michael, Bodenstein, Marc, Groesdonk, Heinrich Volker, Guth, Stefan, Hecker, Matthias, Husain‐Syed, Faeq, Jung, Christian, Napp, L. Christian, Natanov, Ruslan, Trummer, Georg, Treskatsch, Sascha, Welp, Henryk, Avalli, Leonello, Ball, Lorenzo, Belliato, Mirko, Bonizzoli, Manuela, Borrelli, Emma, Cavallaro, Giacomo, Franci, Andrea, Gramaticopolo, Silvia, Panigada, Mauro, Tritapepe, Luigi, Abdulaziz, Salman, Bracco, David, Alexandros, Yiorgos, Joffe, Ari, Nagpal, A. Dave, Sia, Ying, Auzinger, Georg, Zochios, Vasileios, Garcia, Alejandro, Gist, Katja, Lustbader, Dana, Yannopoulos, Demetris, Stephens, R. Scott, Tonna, Joseph, Paxton, Linda, Hirose, Hitoshi, Kim, Bo, Dalén, Magnus, Balik, Martin, Janak, David, Castillo, Luis, Bruhn, Alejandro, Socarras, Jorge Luis Alvarado, Kim, Taeyun, Kim, Hyoung Soo, Byun, Joung Hun, Mainardi, Guilherme, Mendes, Pedro, Giraud, Raphaël, Fortuna, Philip, Fukuda, Tatsuma, Maas, Jacinta, Maciejewski, Dariusz, Pandit, Deblal, Psz, Yosv, Radsel, Peter, YAN, Gangfeng, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CTC, MUMC+: MA Med Staf Spec CTC (9), RS: Carim - V04 Surgical intervention, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and MORNET, Dominique
- Subjects
ARDS ,Internationality ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Medicine (miscellaneous) ,02 engineering and technology ,030204 cardiovascular system & hematology ,extracorporeal life support ,SARS‐CoV‐2 ,Hypoxemia ,0302 clinical medicine ,Surveys and Questionnaires ,Practice Patterns, Physicians' ,ComputingMilieux_MISCELLANEOUS ,Respiratory Distress Syndrome ,General Medicine ,COVID‐19‐induced acute respiratory distress syndrome ,3. Good health ,[SDV] Life Sciences [q-bio] ,SURVIVAL ,medicine.symptom ,Respiratory Insufficiency ,endocrine system ,medicine.medical_specialty ,Critical Illness ,0206 medical engineering ,Biomedical Engineering ,Bioengineering ,Extracorporeal ,Biomaterials ,03 medical and health sciences ,Main Text Articles ,COVID‐19 ,medicine ,Extracorporeal membrane oxygenation ,Humans ,survey ,Main Text Article ,business.industry ,SARS-CoV-2 ,COVID-19-induced acute respiratory distress syndrome ,MEMBRANE-OXYGENATION ,COVID-19 ,extracorporeal membrane oxygenation ,medicine.disease ,020601 biomedical engineering ,Triage ,Discontinuation ,Heart failure ,Life support ,Emergency medicine ,business - Abstract
Extracorporeal life support (ECLS) is a means to support patients with acute respiratory failure. Initially, recommendations to treat severe cases of pandemic coronavirus disease 2019 (COVID‐19) with ECLS have been restrained. In the meantime, ECLS has been shown to produce similar outcomes in patients with severe COVID‐19 compared to existing data on ARDS mortality. We performed an international email survey to assess how ECLS providers worldwide have previously used ECLS during the treatment of critically ill patients with COVID‐19. A questionnaire with 45 questions (covering, e.g., indication, technical aspects, benefit, and reasons for treatment discontinuation), mostly multiple choice, was distributed by email to ECLS centers. The survey was approved by the European branch of the Extracorporeal Life Support Organization (ELSO); 276 ECMO professionals from 98 centers in 30 different countries on four continents reported that they employed ECMO for very severe COVID‐19 cases, mostly in veno‐venous configuration (87%). The most common reason to establish ECLS was isolated hypoxemic respiratory failure (50%), followed by a combination of hypoxemia and hypercapnia (39%). Only a small fraction of patients required veno‐arterial cannulation due to heart failure (3%). Time on ECLS varied between less than 2 and more than 4 weeks. The main reason to discontinue ECLS treatment prior to patient’s recovery was lack of clinical improvement (53%), followed by major bleeding, mostly intracranially (13%). Only 4% of respondents reported that triage situations, lack of staff or lack of oxygenators, were responsible for discontinuation of ECLS support. Most ECLS physicians (51%, IQR 30%) agreed that patients with COVID‐19‐induced ARDS (CARDS) benefitted from ECLS. Overall mortality of COVID‐19 patients on ECLS was estimated to be about 55%. ECLS has been utilized successfully during the COVID‐19 pandemic to stabilize CARDS patients in hypoxemic or hypercapnic lung failure. Age and multimorbidity limited the use of ECLS. Triage situations were rarely a concern. ECLS providers stated that patients with severe COVID‐19 benefitted from ECLS., 276 ECMO professionals from 98 centers worldwide participated in this EuroELSO‐associated online survey investigating the use of ECMO for severe COVID‐19. Extracorporeal life support (ECLS) for severe COVID‐19 was used predominantly in veno‐venous configuration (87%) to treat isolated hypoxic respiratory failure (50%). Age and multimorbidity limited the use of ECLS. Overall mortality of COVID‐19 patients on ECLS was estimated to be about 55%.
- Published
- 2021
- Full Text
- View/download PDF
153. The Tyrosine Kinase Substrate eps15 Is Constitutively Associated with the Plasma Membrane Adaptor AP-2
- Author
-
Benmerah, Alexandre, Gagnon, Jean, Bègue, Bernadette, Mégarbané, Bruno, Dautry-Varsat, Alice, and Cerf-Bensussan, Nadine
- Published
- 1995
154. Exposition involontaire au tramadol à libération immédiate chez les enfants ≤ 6 ans – Une étude nationale des centres antipoison français
- Author
-
Vodovar, Dominique, primary, Tangre, Alexane, additional, Care, Weniko, additional, Laborde-Casterot, Hervé, additional, Dufayet, Laurène, additional, Megarbane, Bruno, additional, and Langrand, Jérome, additional
- Published
- 2021
- Full Text
- View/download PDF
155. Intoxication par graines de ricin : intérêt du suivi de la ricinine par Chromatographie Liquide couplée à la Spectrométrie de Masse en Haute Résolution
- Author
-
Thiebot, Pauline, primary, Maaziz, Nada, additional, Oppon, Chrystelle, additional, Bertolo, Laetitia, additional, Megarbane, Bruno, additional, Houze, Pascal, additional, and Labat, Laurence, additional
- Published
- 2021
- Full Text
- View/download PDF
156. Consommation dans un cadre festif de GHB et de X-MMC : une association dangereuse !
- Author
-
Boukerma, Arezki Khaled, primary, Delor, Louise, additional, Mihoubi, Amine, additional, Gourlain, Hervé, additional, Megarbane, Bruno, additional, Houze, Pascal, additional, and Labat, Laurence, additional
- Published
- 2021
- Full Text
- View/download PDF
157. Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial
- Author
-
Rouzé, Anahita, primary, Martin-Loeches, Ignacio, additional, Povoa, Pedro, additional, Metzelard, Matthieu, additional, Du Cheyron, Damien, additional, Lambiotte, Fabien, additional, Tamion, Fabienne, additional, Labruyere, Marie, additional, Boulle Geronimi, Claire, additional, Nieszkowska, Ania, additional, Nyunga, Martine, additional, Pouly, Olivier, additional, Thille, Arnaud W., additional, Megarbane, Bruno, additional, Saade, Anastasia, additional, Diaz, Emili, additional, Magira, Eleni, additional, Llitjos, Jean-François, additional, Cilloniz, Catia, additional, Ioannidou, Iliana, additional, Pierre, Alexandre, additional, Reignier, Jean, additional, Garot, Denis, additional, Kreitmann, Louis, additional, Baudel, Jean-Luc, additional, Fartoukh, Muriel, additional, Plantefeve, Gaëtan, additional, Beurton, Alexandra, additional, Asfar, Pierre, additional, Boyer, Alexandre, additional, Mekontso-Dessap, Armand, additional, Makris, Demosthenes, additional, Vinsonneau, Christophe, additional, Floch, Pierre-Edouard, additional, Weiss, Nicolas, additional, Ceccato, Adrian, additional, Artigas, Antonio, additional, Bouchereau, Mathilde, additional, Duhamel, Alain, additional, Labreuche, Julien, additional, Nseir, Saad, additional, Poissy, Julien, additional, Favory, Raphaël, additional, Preau, Sébastien, additional, Jourdain, Mercè, additional, Boyd, Sean, additional, Coelho, Luis, additional, Cuchet, Pierre, additional, Zarrougui, Wafa, additional, Boyer, Déborah, additional, Quenot, Jean-Pierre, additional, Imouloudene, Mehdi, additional, Luyt, Charles-Edouard, additional, van der Linden, Thierry, additional, Bardin, Justine, additional, Voicu, Sebastian, additional, Azoulay, Elie, additional, Goma, Gemma, additional, Pene, Frédéric, additional, Torres, Antoni, additional, Thevenin, Didier, additional, Ehrmann, Stéphan, additional, Argaud, Laurent, additional, Guidet, Bertrand, additional, Voiriot, Guillaume, additional, Contou, Damien, additional, Le Marec, Julien, additional, Demiselle, Julien, additional, Meguerditchian, David, additional, Razazi, Keyvan, additional, Tsolaki, Vassiliki, additional, Sejourne, Caroline, additional, Brunin, Guillaume, additional, Le Guennec, Loïc, additional, and Morales, Luis, additional
- Published
- 2021
- Full Text
- View/download PDF
158. Pediatric Acute Alcohol Intoxication Admitted to the ICU: A Review of 102 Cases in France
- Author
-
Ruetsch, Valerie, primary, Zarka, Jonathan, additional, Vanel, Blandine, additional, Tissieres, Pierre, additional, Megarbane, Bruno, additional, Renolleau, Sylvain, additional, Dauger, Stéphane, additional, Guilbert, Anne-Sophie, additional, Leteurtre, Sylvain, additional, Charpentier, Julien, additional, Vaugier, Isabelle, additional, and Bergounioux, Jean, additional
- Published
- 2021
- Full Text
- View/download PDF
159. Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units
- Author
-
Voiriot, Guillaume, primary, Fartoukh, Muriel, additional, Durand-Zaleski, Isabelle, additional, Berard, Laurence, additional, Rousseau, Alexandra, additional, Armand-Lefevre, Laurence, additional, Verdet, Charlotte, additional, Argaud, Laurent, additional, Klouche, Kada, additional, Megarbane, Bruno, additional, Patrier, Juliette, additional, Richard, Jean-Christophe, additional, Reignier, Jean, additional, Schwebel, Carole, additional, Souweine, Bertrand, additional, Tandjaoui-Lambiotte, Yacine, additional, Simon, Tabassome, additional, and Timsit, Jean-François, additional
- Published
- 2021
- Full Text
- View/download PDF
160. Are sodium nitrite exposures increasing in the United States?
- Author
-
Vodovar, Dominique, primary and Megarbane, Bruno, additional
- Published
- 2021
- Full Text
- View/download PDF
161. Non–C. difficileClostridioides Bacteremia in Intensive Care Patients, France
- Author
-
Morel, Guillaume, primary, Mulier, Guillaume, additional, Ghrenassia, Etienne, additional, Abdel Nabey, Moustafa, additional, Tandjaoui, Yacine, additional, Kouatchet, Achille, additional, Platon, Laura, additional, Pène, Frédéric, additional, Moreau, Anne-Sophie, additional, Seguin, Amelie, additional, Contou, Damien, additional, Sonneville, Romain, additional, Rousset, David, additional, Picard, Muriel, additional, Dumas, Guillaume, additional, Mokart, Djamel, additional, Megarbane, Bruno, additional, Voiriot, Guillaume, additional, Oddou, Isabelle, additional, Azoulay, Elie, additional, Biard, Lucie, additional, and Zafrani, Lara, additional
- Published
- 2021
- Full Text
- View/download PDF
162. Influenza vaccination and prognosis of COVID ‐19 in hospitalized patients with diabetes: Results from the CORONADO study
- Author
-
Diallo, A, Pichelin, Matthieu, Wargny, Matthieu, Gourdy, Pierre, Bonnet, JB, Hadjadj, Samy, Cariou, Bertrand, Sultan, Ariane, Galtier, Florence, Mahot, Pascale, Fournier‐Guilloux, Anne‐Laure, Mauduit, Nicolas, Bigot‐corbel, Edith, Boureau, Anne‐Sophie, Dekcer, Laure, Ernould, Audrey, Primot, Claire, Seguin, Anne, Joliveau, Marielle, Pouvreau, Sonia, FOURNIER, Chloé, Thureau, Jeremy, Fonteneau, Edith, Hublain, Pamela, Nantes, Chu, Agasse, Carole, Kergaradec, Mathilde DE, Minville, Vincent, Vardon‐Bounes, Fanny, Martin‐Blondel, Guillaume, Tramunt, Blandine, Turnin, Marie‐Christine, Hanaire, Hélène, Mansuy, Jean‐Michel, Fabre, Didier, Arhainx, Marie‐Blanche, Cazals, Laurent, Combes, Laure, Lami, Emmanuelle, Cianferani, Mallory, Megarbane, Bruno, Leroy, Pierre, Gautier, Jean‐François, Vidal‐Trecan, Tiphaine, Riveline, Jean‐Pierre, Laplanche, Jean‐Louis, Mouly, Stéphane, Potier, Louis, Roussel, Ronan, Taher, Malak, Abouleka, Yawa, Yaker, Fetta, Carlier, Aurelie, Boutten, Anne, Hallot‐Feron, Marilyne, Mourah, Fadila, Thivolet, Charles, Blond, Emilie, Rolland, Muriel, Mendez, Josep Verdecho, Alexandre, Marine, Pottecher, Julien, Richer, Emilie, Meyer, Laurent, Luca, Florina, Lessinger, Jean‐Marc, Bahougne, Thibault, Guerci, Bruno, Ludwig, Lisa, Benzirar, Siham, Malaplate, Catherine, Matton, Thierry, Poissy, Julien, Faure, Karine, Fontaine, Pierre, Baudoux, Florence, Vambergue, Anne, Pekar, Jean David, Lambert, Marc, Yelnik, Cécile, Bruandet, Amélie, Petit, Laurent, Neau, Didier, Rigalleau, Vincent, Berard, Annie, Galioot, Amandine, Coudroy, Remy, Thille, Arnaud, Robert, René, Roblot‐Cazenave, France, Rammaert, Blandine, Saulnier, Pierre Jean, Piguel, Xavier, Benhenda, Nesrine, Husson, Camille, Olivier, Celine, Torremocha, Florence, Fraty, Mathilde, d'assigny, Marie Flamen, Miot, Aurelie, Bossard, Valentin, Klouche, Kada, Makinson, Alain, Bonnet, Jean‐Baptiste, Foulongne, Vincent, Aubron, Cécile, Ansart, Séverine, Kerlan, Véronique, Quiniou, Pascale, Carre, Jean‐Luc, Quesnot, Stéphane, Laviolle, Bruno, Schwebel, Carole, Epaulard, Olivier, Benhamou, Pierre‐Yves, Betry, Cécile, Borel, Anne‐Laure, Lablanche, Sandrine, Guergour, Dorra, Duclos, Catherine, Cosson, Emmanuel, Guyot, Erwan, Deniau, Aurore, Nguyen, Phucthutrang, Reznik, Yves, Joubert, Michael, Allouche, Stéphane, Guittet, Lydia, Grange, Steven, Etienne, Manuel, Prévost, Gaëtan, Brunel, Valéry, Lagier, Jean‐Christophe, Raoult, Didier, Dutour, Anne, Gaborit, Bénédicte, Boulllu, Sandrine, Darmon, Patrice, Lasbleiz, Adèle, Cerino, Mathieu, Romain, Fanny, Houssays, Marie, Quenot, Jean Pierre, Piroth, Lionel, Vergès, Bruno, Duvillard, Laurence, Bonnotte, Bernard, Mercat, Alain, Dubee, Vincent, Allix, Ingrid, Rodien, Patrice, Dhersin, Robin, Lebeault, Maylis, Trzepizur, Wojciech, Loison, Jocelyne, Brangier, Antoine, Asfar, Pierre, Reynier, Pascal, Larcher, Françoise, Joubaud, Françoise, Andreu, Marie‐Rita, Urbanski, Geoffrey, Hubert, Laurent, Annweiler, Cedric, Dellamonica, Jean, Courjon, Johan, Chevalier, Nicolas, Chinetti, Giulia, Chafai, Magda, Mourvillier, Bruno, Bani‐Sadr, Firouze, Barraud, Sarra, Delemer, Brigitte, Gillery, Philippe, Labedade, Pascale, Chabrol, Amélie, Penfornis, Alfred, Petit, Catherine, Amadou, Coralie, Adler, Maxime, Dubost, Clément, Conan, Pierre‐Louis, Bordier, Lyse, Ceppa, Franck, Garcia, Cyril, Sollier, Mathilde, Dupuy, Olivier, Laplance, Sophie, Billuart, Olivier, Aroulanda, Marie Joseph, Olivier, Frédérique, Ayon, Florence, Wilhelm, Nathalie, Epelboin, Loic, Sabbah, Nadia, Charpin, Aurelie, Squara, Pierre, Belliard, Olivier, Dubois, Claude, Marre, Michel, Auchabie, Johann, Courtois, Roxane, Duriez, Thierry, Mergey, Tiphaine, Vallee, Laura, Seguin, Laetitia, Al‐Salameh, Abdallah, Lanoix, Jean‐Philippe, Soriot‐Thomas, Sandrine, Bourgeois‐Descouls, Anne‐Marie, Desailloud, Rachel, Germain, Natacha, Galusca, Bogdan, Belleton, Gwenaelle, Marouani, Nesrine, Palaghiu, Delia, Hammour, Amira, Berdaguer, Fernando, Klopfenstein, Thimothée, Zayet, Hajer, Winiszewski, Patrice, Zanusso, Marie, Garnier, Pauline, Julier, Ingrid, Hamzaoui, Karim, Marty‐Gres, Sophie, Sadki, Tarik, Cadot, Lucile, Dubost, Jean‐Louis, Gonfroy, Céline, Campinos, Catherine, Martres, Pascale, Coulhon, Marie Pierre, Allou, Nicolas, Bachir, Marwa, Hoang, Stella, Kembellec, Candice, Suply, Olivia, Kharcha, Fatima, Devouge, Anne‐Claire, Flaus‐Furmanuk, Anna, Madeline, Isabelle, Ehinger, Vincent, Bastard, Sophie, Raffray, Loic, Renou, Frederic, Bojarski, Aude, Paul, Caroline, Borsu, Karine, Gorlin, Angelique, Bernardo, Servane, Ut, Carole Truong, Renaud, Stephane, Vignoles, Antoine, Foch, Emilie, Masse, Laurie, Grand, Hubert, Ferrand, Helene, Raffaitin‐Cardin, Christelle, Zellagui, Hadjer, Castang‐Brachet, Celine, Boury, Frederique, Tena, Ana Alvarez, Moura, Isabelle, Kalfon, Pierre, Darasteanu, Juliana, Monier, Arnaud, Foucault, Pascal, Depuille, Alexandra, Laugier‐Robiolle, Stéphanie, Caneiro, Patrick, Basso, Maud, Larger, Etienne, Bouam, Samir, Benzenati, Wahiba, Bachir, Leila Ait, Pillegand, Camille Cussac, Vasse, Marc, Michard, Christophe, Montanier, Nathanaëlle, Millot, Luc, Crepet, Françoise, Ratsimba, Danielle, Bouiller, Kevin, Borot, Sophie, Bruckert, Isabelle, Clergeot, Annie, Schillo, Franck, Vignes, Dorothée, Bourgeon‐Ghittori, Muriel, Lachgar, Hamoud, Cursay, Claire Lambert DE, Levante, Stéphane, Auregan, Jean Charles, Merlet, Antoine, Zaragoza, Cécile, Arnault, Gwénaëlle, Loupp, Anne‐Gaëlle, Lesieur, Olivier, Roncato‐Saberan, Mariam, Gouet, Didier, Lemarie, Romain, Allano, Hong_an, Vivier, Emmanuel, Pariset, Caroline, Luyton, Cédric, Marchand, Lucien, Doroszewski, Fanny, Pecquet, Matthieu, Perard, Laurent, Vuillermoz‐Blas, Sylvie, Kacki, Nicolas, Charrier, Patricia, Ducet‐Boiffard, Amélie, Roure, Françoise Desroys, Bourron, Olivier, Bonnefont‐Rousselot, Dominique, Laroche, Suzanne, Phan, Franck, Hartemann, Agnès, CAUSSY, Cyrielle, Disse, Emmanuel, Guerin, Claude, Perpoint, Thomas, Moulin, Philippe, CARTIER, RÉGINE, Hariri, Geoffroy, Chopin, Dorothée, Vatier, Camille, Bourcigaux, Nathalie, Chaigneau, Emmanuelle, Christin‐Maitre, Sophie, Donadille, Bruno, Feve, Bruno, Lamothe, Sophie, Sarfati, Julie, Pernet, Pascal, Chambon, Anne, Demarsy, Delphine, Campagne, Hugo, Latil‐Plat, Françoise, Berne, Monica, Grinand, Marilyne, Touzet, Marion, Zabulon, Aydrey, Craspag, Jocelyne, Ledoux, Catherine, Contaret, Cedric, Janand‐Delenne, Blandine, Giraud, Anaïs, Lacrimini, Marie Lou, Arrivie, Joëlle, Ancelle, Deborah, Guillois, Carine, Fremy, Bénédicte, Chaalal, Amina, Barrande, Gaëlle, Dorange, Anne, Rouanet, Eglantine, Seret‐Begue, Dominique, Saoud, Audrey, Guedj, Anne‐Marie, Bedos, Nathalie, Velayoudom, Fritz‐Line, Dumas, Marie, Gonda, Benoite, Coffin, Christine, Gibiat, Stéphanie, Lungo, Myriam, Bully, Chantal, Serusclat, Pierre, Bully, Stella, Carre, Patricia, Leberre, Jean‐Philippe, Elkhoury, Carlos, THIEUX, Marine, Paradisi‐Prieur, Laetitia, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
- Subjects
2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Hospitalized patients ,Influenza vaccine ,Endocrinology, Diabetes and Metabolism ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,[SDV]Life Sciences [q-bio] ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Diabetes mellitus ,Influenza, Human ,Internal Medicine ,Diabetes Mellitus ,Research Letter ,Medicine ,Humans ,030212 general & internal medicine ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,0303 health sciences ,business.industry ,SARS-CoV-2 ,Vaccination ,COVID-19 ,medicine.disease ,Prognosis ,Research Letters ,3. Good health ,Hospitalization ,Propensity score matching ,business - Abstract
International audience
- Published
- 2021
- Full Text
- View/download PDF
163. Additional file 6 of Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial
- Author
-
Benichou, Nicolas, Saïd Lebbah, Hajage, David, Martin-Lefèvre, Laurent, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, De Prost, Nicolas, Lautrette, Alexandre, Bretagnol, Anne, Mayaux, Julien, Nseir, Saad, Megarbane, Bruno, Thirion, Marina, Forel, Jean-Marie, Maizel, Julien, Hodane Yonis, Markowicz, Philippe, Thiery, Guillaume, Schortgen, Frederique, Tubach, Florence, Jean-Damien Ricard, Dreyfuss, Didier, and Gaudry, Stéphane
- Subjects
surgical procedures, operative ,cardiovascular system - Abstract
Additional file 6: Figure S2. Propensity score distribution between femoral and jugular groups for first catheter insertion.
- Published
- 2021
- Full Text
- View/download PDF
164. Additional file 3 of Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial
- Author
-
Benichou, Nicolas, Saïd Lebbah, Hajage, David, Martin-Lefèvre, Laurent, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, De Prost, Nicolas, Lautrette, Alexandre, Bretagnol, Anne, Mayaux, Julien, Nseir, Saad, Megarbane, Bruno, Thirion, Marina, Forel, Jean-Marie, Maizel, Julien, Hodane Yonis, Markowicz, Philippe, Thiery, Guillaume, Schortgen, Frederique, Tubach, Florence, Jean-Damien Ricard, Dreyfuss, Didier, and Gaudry, Stéphane
- Abstract
Additional file 3: Table S3. Collinearity control: variance inflation factors for fixed effects factors potentially involved in the choice between femoral and jugular for the first catheter insertion.
- Published
- 2021
- Full Text
- View/download PDF
165. Extracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroup
- Author
-
Wong, Anselm, Hoffman, Robert S., Walsh, Steven J., Roberts, Darren M., Gosselin, Sophie, Bunchman, Timothy E., Kebede, Sofia, Lavergne, Valery, Ghannoum, Marc, Badria Alhatali, Anseeuw, Kurt, Berling, Ingrid, Bouchard, Josee, Bird, Steven, Chin, Paul, Doi, Kent, Tais Galvao, Goldfarb, David, Hassanian, Hossein, Hoegberg, Lotte, Siba Kallab, Kielstein, Jan, Li, Yi, Macedo, Etienne, MacLaren, Rob, Megarbane, Bruno, Mowry, Jim, Nolin, Thomas D., Osterman, Marlies, Peng, Ai, Jean-Philippe Roy, Vijayan, Anitha, Wood, David, and Yates, Christopher
- Abstract
Calcium channel blockers (CCBs) are commonly used to treat conditions such as arterial hypertension and supraventricular dysrhythmias. Poisoning from these drugs can lead to severe morbidity and mortality. We aimed to determine the utility of extracorporeal treatments (ECTRs) in the management of CCB poisoning. We conducted systematic reviews of the literature, screened studies, extracted data, summarized findings, and formulated recommendations following published EXTRIP methods. A total of 83 publications (6 in vitro and 1 animal experiments, 55 case reports or case series, 19 pharmacokinetic studies, 1 cohort study and 1 systematic review) met inclusion criteria regarding the effect of ECTR. Toxicokinetic or pharmacokinetic data were available on 210 patients (including 32 for amlodipine, 20 for diltiazem, and 52 for verapamil). Regardless of the ECTR used, amlodipine, bepridil, diltiazem, felodipine, isradipine, mibefradil, nifedipine, nisoldipine, and verapamil were considered not dialyzable, with variable levels of evidence, while no dialyzability grading was possible for nicardipine and nitrendipine. Data were available for clinical analysis on 78 CCB poisoned patients (including 32 patients for amlodipine, 16 for diltiazem, and 23 for verapamil). Standard care (including high dose insulin euglycemic therapy) was not systematically administered. Clinical data did not suggest an improvement in outcomes with ECTR. Consequently, the EXTRIP workgroup recommends against using ECTR in addition to standard care for patients severely poisoned with either amlodipine, diltiazem or verapamil (strong recommendations, very low quality of the evidence (1D)). There were insufficient clinical data to draft recommendation for other CCBs, although the workgroup acknowledged the low dialyzability from, and lack of biological plausibility for, ECTR. Both dialyzability and clinical data do not support a clinical benefit from ECTRs for CCB poisoning. The EXTRIP workgroup recommends against using extracorporeal methods to enhance the elimination of amlodipine, diltiazem, and verapamil in patients with severe poisoning.
- Published
- 2021
- Full Text
- View/download PDF
166. Autoantibodies neutralizing type I IFNs are present in similar to 4% of uninfected individuals over 70 years old and account for similar to 20% of COVID-19 deaths
- Author
-
Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jeremie, Philippot, Quentin, Manry, Jeremy, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina, Bizien, Lucy, Parra-Martinez, Alba, Yang, Rui, Haljasmagi, Liis, Migaud, Melanie, Sarekannu, Karita, Maslovskaja, Julia, de Prost, Nicolas, Tandjaoui-Lambiotte, Yacine, Luyt, Charles-Edouard, Amador-Borrero, Blanca, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal, Richard, Pascale, Cognasse, Fabrice, Troya, Jesus, Trouillet-Assant, Sophie, Belot, Alexandre, Saker, Kahina, Garcon, Pierre, Riviere, Jacques G., Lagier, Jean-Christophe, Gentile, Stephanie, Rosen, Lindsey B., Shaw, Elana, Morio, Tomohiro, Tanaka, Junko, Dalmau, David, Tharaux, Pierre-Louis, Sene, Damien, Stepanian, Alain, Megarbane, Bruno, Triantafyllia, Vasiliki, Fekkar, Arnaud, Heath, James R., Franco, Jose Luis, Anaya, Juan-Manuel, Sole-Violan, Jordi, Imberti, Luisa, Biondi, Andrea, Bonfanti, Paolo, Castagnoli, Riccardo, Delmonte, Ottavia M., Zhang, Yu, Snow, Andrew L., Holland, Steven M., Biggs, Catherine M., Moncada-Velez, Marcela, Arias, Andres Augusto, Lorenzo, Lazaro, Boucherit, Soraya, Coulibaly, Boubacar, Anglicheau, Dany, Planas, Anna M., Haerynck, Filomeen, Duvlis, Sotirija, Nussbaum, Robert L., Ozcelik, Tayfun, Keles, Sevgi, Bousfiha, Ahmed A., El Bakkouri, Jalila, Ramirez-Santana, Carolina, Paul, Stephane, Pan-Hammarstrom, Qiang, Hammarstrom, Lennart, Dupont, Annabelle, Kurolap, Alina, Metz, Christine N., Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Ciceri, Fabio, Barreiros, Lucila A., Dominguez-Garrido, Elena, Vidigal, Mateus, Zatz, Mayana, van de Beek, Diederik, Sahanic, Sabina, Tancevski, Ivan, Stepanovskyy, Yurii, Boyarchuk, Oksana, Nukui, Yoko, Tsumura, Miyuki, Vidaur, Loreto, Tangye, Stuart G., Burrel, Sonia, Duffy, Darragh, Quintana-Murci, Lluis, Klocperk, Adam, Kann, Nelli Y., Shcherbina, Anna, Lau, Yu-Lung, Leung, Daniel, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angelique, Venet, Fabienne, Monneret, Guillaume, Nussenzweig, Michel C., Arrestier, Romain, Boudhabhay, Idris, Baris-Feldman, Hagit, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H., Kennelly, Sean P., Bourke, Nollaig M., Halwani, Rabih, Sharif-Askari, Narjes Saheb, Dorgham, Karim, Sallette, Jerome, Sedkaoui, Souad Mehlal, AlKhater, Suzan, Rigo-Bonnin, Raul, Morandeira, Francisco, Roussel, Lucie, Vinh, Donald C., Ostrowski, Sisse Rye, Condino-Neto, Antonio, Prando, Carolina, Bondarenko, Anastasiia, Spaan, Andras N., Gilardin, Laurent, Fellay, Jacques, Lyonnet, Stanislas, Bilguvar, Kaya, Lifton, Richard P., Mane, Shrikant, Anderson, Mark S., Boisson, Bertrand, Beziat, Vivien, Zhang, Shen-Ying, Andreakos, Evangelos, Hermine, Olivier, Pujol, Aurora, Peterson, Part, Mogensen, Trine H., Rowen, Lee, Mond, James, Debette, Stephanie, de Lamballerie, Xavier, Duval, Xavier, Mentre, France, Zins, Marie, Soler-Palacin, Pere, Colobran, Roger, Gorochov, Guy, Solanich, Xavier, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier, Vasse, Marc, Gregersen, Peter K., Piemonti, Lorenzo, Rodriguez-Gallego, Carlos, Notarangelo, Luigi D., Su, Helen C., Kisand, Kai, Okada, Satoshi, Puel, Anne, Jouanguy, Emmanuelle, Rice, Charles M., Tiberghien, Pierre, Zhang, Qian, Cobat, Aurelie, Abel, Laurent, Casanova, Jean-Laurent, and Gunst, Jan
- Subjects
INTERFERON ,alpha ,Science & Technology ,ANTINUCLEAR ,myasthenia-gravis patients ,AUTOIMMUNITY ,autoimmunity ,Immunology ,interferon ,IMMUNITY ,immunity ,DISTINCT FUNCTIONS ,PATIENT ,ALPHA ,ANTIBODIES ,antibodies ,patient ,distinct functions ,Life Sciences & Biomedicine ,MYASTHENIA-GRAVIS PATIENTS ,antinuclear - Abstract
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases. ispartof: SCIENCE IMMUNOLOGY vol:6 issue:62 ispartof: location:United States status: published
- Published
- 2021
167. Additional file 5 of Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial
- Author
-
Benichou, Nicolas, Saïd Lebbah, Hajage, David, Martin-Lefèvre, Laurent, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, De Prost, Nicolas, Lautrette, Alexandre, Bretagnol, Anne, Mayaux, Julien, Nseir, Saad, Megarbane, Bruno, Thirion, Marina, Forel, Jean-Marie, Maizel, Julien, Hodane Yonis, Markowicz, Philippe, Thiery, Guillaume, Schortgen, Frederique, Tubach, Florence, Jean-Damien Ricard, Dreyfuss, Didier, and Gaudry, Stéphane
- Abstract
Additional file 5: Figure S1. Cumulative incidence of catheter replacement and death, for first catheter, according to insertion site (jugular and femoral).
- Published
- 2021
- Full Text
- View/download PDF
168. Additional file 4 of Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial
- Author
-
Benichou, Nicolas, Saïd Lebbah, Hajage, David, Martin-Lefèvre, Laurent, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, De Prost, Nicolas, Lautrette, Alexandre, Bretagnol, Anne, Mayaux, Julien, Nseir, Saad, Megarbane, Bruno, Thirion, Marina, Forel, Jean-Marie, Maizel, Julien, Hodane Yonis, Markowicz, Philippe, Thiery, Guillaume, Schortgen, Frederique, Tubach, Florence, Jean-Damien Ricard, Dreyfuss, Didier, and Gaudry, Stéphane
- Abstract
Additional file 4: Table S4. Covariate balance between femoral and jugular groups before and after propensity score weighting for first catheter insertion.
- Published
- 2021
- Full Text
- View/download PDF
169. Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia
- Author
-
Hermine, Olivier, Mariette, Xavier, Tharaux, Pierre-Louis, Resche-Rigon, Matthieu, Porcher, Raphaël, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Pourchet-Martinez, Valérie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Dalibey, Sarah, Raked, Nabil, Mameri, Lakhdar, Alary, Stéphanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Montlahuc, Claire, Biard, Lucie, Charreteur, Robin, Dupré, Celine, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madeleine, Claire, DOrtenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Pavy, Stéphan, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stéphane, Baudry, Elodie, Verny, Christiane, Lefèvre, Edouard, Zaidan, Mohamad, Le Tiec, Clotilde Le Tiec, Verstuyft, Céline Verstuyft, Roques, Anne-Marie, Grimaldi, Lamiae, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Solène, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Georgin-Lavialle, Sophie, Senet, Patricia, Soria, Angèle, Parrot, Antoine, François, Hélène, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadège, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefèvre, Guillaume, Fallet, Vincent, Gottenberg, Jacques-Eric, Hansmann, Yves, Andres, Emmanuel, Bayer, Sophie, Becker, Guillaume, Blanc, Frédéric, Brin, Stéphane, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Demonsant, Eric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurélien, Heger, Bob, Hutt, Anne, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Martin, Tristan, Mertes, Paul Michel, Metzger, Catherine, Meyer, Nicolas, Nisand, Gabriel, Noll, Eric, Oberlin, Mathieu, Ohlmann-Caillard, Sophie, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Sublon, Cédric, Tayebi, Hakim, Weill, François, Mekinian, Arsène, Chopin, Dorothée, Fain, Olivier, Garnier, Marc, Krause Le Garrec, Jessica, Morgand, Marjolaine, Pacanowski, Jerome, Urbina, Tomas, Mcavoy, Chloe, Pereira, Maria, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Daguenel Nguyen, Anne, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean- Se´bastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Penet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Jesuthasan, Denis, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Vale´rie, Tre´Han, Anne, Vigna, Ve´ronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charle`ne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, Xavier, Ghosn, Jade, Bachelard, Antoine, Bironne, Timothee, Borie, Raphael, Bounhiol, Agathe, Boussard, Catherine, Chauffier, Jeanne, Chalal, Solaya, Chalal, Lynda, Chansombat, Malikhone, Crespin, Paul, Crestani, Bruno, Daconceicao, Olivia, Deconinck, Laurene, Dieude, hilippe, Dossier, Antoine, Dubert, Marie, Ducrocq, Greggory, Fuentes, Axelle, Gervais, Anne, Gilbert, Marie, Isernia, Valentina, Ismael, Sophie, Joly, Veronique, Julia, Zelie, Lariven, Sylvie, Le Gac, Sylvie, Le Pluart, Diane, Louni, Francoise, Ndiaye, Awa, Papo, Thomas, Parisey, Marion, Phung, Bao, Pourbaix, Annabelle, Rachline, Anne, Rioux, Christophe, Sautereau, Aurelie, Steg, Gabriel, Tharini, Hassan, Valayer, Simon, Vallois, Dorothee, Vermes, Paul, Volpe, Thomas, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anaïs, Zarrouk, Virginie, De Lastours, Victoire, Uzzan, Matthieu, Gamany, Naura, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, De Castro, Nathalie, Clément, Melissa, Darmont, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lengliné, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asmaa, Mariotte, Eric, Martin De Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault De Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Celli Lebras, Karine, Chabert, Julien, Djaghout, Lalia, Fauvaux, Catherine, Jegu, Anne Lise, Kozaliewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madeleine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, Sene, Damien, Burlacu, Ruxandra, Chousterman, Benjamin, Megarbane, Bruno, Richette, Pascal, Riveline, Jean-Pierre, Frazier, Aline, Vicaut, Eric, Berton, Laure, Hadjam, Tassadit, Vasquez-Ibarra, Miguel Alejandro, Jourdaine, Clément, Jacob, Aude, Smati, Julie, Renaud, Stéphane, Manivet, Philippe, Pernin, Claire, Suarez, Lydia, Semerano, Luca, Abad, Sebastien, Benainous, Ruben, Bloch Queyrat, Coralie, Bonnet, Nicolas, Brahmi, Sabrina, Cailhol, johann, Cohen, Yves, Comparon, Celine, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Giroux-Leprieur, Benedicte, Goupil De Bouille, Jeanne, Jacolot, Anne, Nunes, Hilario, Oziel, Johanna, Rathouin, Vanessa, Rigal, Marthe, Roulot, Dominique, Tantet, Claire, Uzunhan, Yurdagul, Costedoat-Chalumeau, Nathalie, Ait Hamou, Zakaria, Benghanem, Sarah, Blanche, Philippe, Canoui, Etienne, Carlier, Nicolas, Chaigne, Benjamin, Contejean, Adrien, Dunogue, Bertrand, Dupland, Pierre, Durel - Maurisse, Aurélie, Gauzit, Remy, Jaubert, Paul, Joumaa, Hassan, Jozwiak, Mathieu, Kerneis, Solen, Lachatre, Marie, Lafoeste, Hélène, Legendre, Paul, Luong Nguyen, Liem Binh, Marey, Jonathan, Morbieu, Caroline, Mouthon, Luc, Nguyen, Lee, Palmieri, Lola-Jade, Regent, Alexis, Szwebel, Tali-Anne, Terrier, Benjamin, Guerin, Corinne, Zerbit, Jérémie, Cheref, Kahina, Chitour, Kamil, Cisse, Mamadou Salif, Clarke, Ada, Clavere, Gaelle, Dusanter, Isabelle, Gaudefroy, Caroline, Jallouli, Moez, Kolta, Sami, Le Bourlout, Catherine, Marin, Nathalie, Menage, Nathalie, Moores, Alexandre, Peigney, Isabelle, Pierron, Cédric, Saleh-Mghir, Samira, Vallet, Mathilde, Michel, Marc, Melica, Giovanna, Lelievre, Jean-Daniel, Fois, Elena, Lim, Pascal, Matignon, Marie, Guillaud, Constance, Thiemele, Alaki, Schmitz, David, Bouhris, Marion, Belazouz, Syllia, Languille, Laetitia, Mekontso-Dessaps, Armand, Sadaoui, Thiziri, Mayaux, Julien, Cacoub, Patrice, Corvol, Jean-Christophe, Louapre, Céline, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aïcha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sébastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Lecronier, Marie, Beurton, Alexandra, Haudebourg, Luc, Deleris, Robin, Le Marec, Julien, Virolle, Sara, Nemlaghi, Safaa, Bureau, Côme, Mora, Pierre, De Sarcus, Martin, Clovet, Olivier, Duceau, Baptiste, Grisot, Paul Henri, Pari, Marie hélène, Arzoine, Jérémy, Clarac, Ulrich, Faure, Morgane, Delemazure, Julie, Decavele, Maxence, Morawiec, Elise, Demoule, Alexandre, Dres, Martin, Vautier, Mathieu, Allenbach, Yves, Benveniste, Olivier, Leroux, Gaelle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Cloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Gonçalo, Ferfar, Yasmina, Charbonnier, Fanny, Aguilar, Claire, Alby-Laurent, Fanny, Alyanakian, Marie-Alexandra, Bakouboula, Prissile, Broissand, Christine, Burger, Carole, Campos-Vega, Clara, Chavarot, Nathalie, Choupeaux, Laure, Elie, Caroline, Fournier, Benjamin, Granville, Sophie, Issorat, Elodie, Rouzaud, Claire, Vimpere, Damien, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Helene, Duclos-Vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Koumis, Ilias, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Chistophe, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El Amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Hélène, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Clan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Servettaz, Amélie, Deslée, Gaetan, Wynckel, Alain, Benoit, Philippe, Marquis, Eric, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Hélène, Mourad, Jean-Jacques, Sacco, Emmanuelle, Renet, Sophie, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de Rhumatologie [CHU Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Equipe 2 : ECSTRA - Epidémiologie Clinique, STatistique, pour la Recherche en Santé (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hopital Saint-Louis [AP-HP] (AP-HP), Centre d'épidémiologie Clinique [Hôtel-Dieu], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Hôtel Dieu, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Centre de recherche en Myologie – U974 SU-INSERM, Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CORIMUNO-19 Collaborative Group, Porcher, Raphaël, Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), and ANR-21-COVR-0024,ACT-LONG-COVID,Caractérisation clinique et biologique du syndrome d'activation mastocytaire dans le COVID long et prédisposition génétique(2021)
- Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal Medicine - Abstract
International audience; Importance Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19).Objective To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia.Design, Setting, and Particpants This cohort-embedded, investigator-initiated, multicenter, open-label, bayesian randomized clinical trial investigating patients with COVID-19 and moderate or severe pneumonia requiring at least 3 L/min of oxygen but without ventilation or admission to the intensive care unit was conducted between March 31, 2020, to April 18, 2020, with follow-up through 28 days. Patients were recruited from 9 university hospitals in France. Analyses were performed on an intention-to-treat basis with no correction for multiplicity for secondary outcomes.Interventions Patients were randomly assigned to receive TCZ, 8 mg/kg, intravenously plus usual care on day 1 and on day 3 if clinically indicated (TCZ group) or to receive usual care alone (UC group). Usual care included antibiotic agents, antiviral agents, corticosteroids, vasopressor support, and anticoagulants.Main Outcomes and Measures Primary outcomes were scores higher than 5 on the World Health Organization 10-point Clinical Progression Scale (WHO-CPS) on day 4 and survival without need of ventilation (including noninvasive ventilation) at day 14. Secondary outcomes were clinical status assessed with the WHO-CPS scores at day 7 and day 14, overall survival, time to discharge, time to oxygen supply independency, biological factors such as C-reactive protein level, and adverse events.Results Of 131 patients, 64 patients were randomly assigned to the TCZ group and 67 to UC group; 1 patient in the TCZ group withdrew consent and was not included in the analysis. Of the 130 patients, 42 were women (32%), and median (interquartile range) age was 64 (57.1-74.3) years. In the TCZ group, 12 patients had a WHO-CPS score greater than 5 at day 4 vs 19 in the UC group (median posterior absolute risk difference [ARD] −9.0%; 90% credible interval [CrI], −21.0 to 3.1), with a posterior probability of negative ARD of 89.0% not achieving the 95% predefined efficacy threshold. At day 14, 12% (95% CI −28% to 4%) fewer patients needed noninvasive ventilation (NIV) or mechanical ventilation (MV) or died in the TCZ group than in the UC group (24% vs 36%, median posterior hazard ratio [HR] 0.58; 90% CrI, 0.33-1.00), with a posterior probability of HR less than 1 of 95.0%, achieving the predefined efficacy threshold. The HR for MV or death was 0.58 (90% CrI, 0.30 to 1.09). At day 28, 7 patients had died in the TCZ group and 8 in the UC group (adjusted HR, 0.92; 95% CI 0.33-2.53). Serious adverse events occurred in 20 (32%) patients in the TCZ group and 29 (43%) in the UC group (P = .21).Conclusions and Relevance In this randomized clinical trial of patients with COVID-19 and pneumonia requiring oxygen support but not admitted to the intensive care unit, TCZ did not reduce WHO-CPS scores lower than 5 at day 4 but might have reduced the risk of NIV, MV, or death by day 14. No difference on day 28 mortality was found. Further studies are necessary for confirming these preliminary results.Trial Registration ClinicalTrials.gov Identifier: NCT04331808
- Published
- 2021
- Full Text
- View/download PDF
170. Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial
- Author
-
Rouze, Anahita Martin-Loeches, Ignacio Povoa, Pedro and Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien and Tamion, Fabienne Labruyere, Marie Geronimi, Claire Boulle and Nieszkowska, Ania Nyunga, Martine Pouly, Olivier Thille, Arnaud W. Megarbane, Bruno Saade, Anastasia Diaz, Emili and Magira, Eleni Llitjos, Jean-Francois Cilloniz, Catia and Ioannidou, Iliana Pierre, Alexandre Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean-Luc Fartoukh, Muriel and Plantefeve, Gaetan Beurton, Alexandra Asfar, Pierre Boyer, Alexandre Mekontso-Dessap, Armand Makris, Demosthenes and Vinsonneau, Christophe Floch, Pierre-Edouard Weiss, Nicolas and Ceccato, Adrian Artigas, Antonio Bouchereau, Mathilde and Duhamel, Alain Labreuche, Julien Nseir, Saad CoVAPid Study Grp
- Subjects
virus diseases ,respiratory tract diseases - Abstract
Rationale: Early empirical antimicrobial treatment is frequently prescribed to critically ill patients with coronavirus disease (COVID-19) based on Surviving Sepsis Campaign guidelines. Objectives: We aimed to determine the prevalence of early bacterial identification in intubated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, as compared with influenza pneumonia, and to characterize its microbiology and impact on outcomes. Methods: A multicenter retrospective European cohort was performed in 36 ICUs. All adult patients receiving invasivemechanical ventilation.48 hours were eligible if they had SARS-CoV-2 or influenza pneumonia at ICU admission. Bacterial identification was defined by a positive bacterial culture within 48 hours after intubation in endotracheal aspirates, BAL, blood cultures, or a positive pneumococcal or legionella urinary antigen test. Measurements and Main Results: A total of 1,050 patients were included (568 in SARS-CoV-2 and 482 in influenza groups). The prevalence of bacterial identification was significantly lower in patients with SARS-CoV-2 pneumonia compared with patients with influenza pneumonia (9.7 vs. 33.6%; unadjusted odds ratio, 0.21; 95% confidence interval [CI], 0.15-0.30; adjusted odds ratio, 0.23; 95% CI, 0.16-0.33; P, 0.0001). Gram-positive cocci were responsible for 58% and 72% of coinfection in patients with SARS-CoV-2 and influenza pneumonia, respectively. Bacterial identification was associated with increased adjusted hazard ratio for 28-day mortality in patients with SARS-CoV-2 pneumonia (1.57; 95% CI, 1.01-2.44; P = 0.043). However, no significant difference was found in the heterogeneity of outcomes related to bacterial identification between the two study groups, suggesting that the impact of coinfection on mortality was not different between patients with SARS-CoV-2 and influenza. Conclusions: Bacterial identification within 48 hours after intubation is significantly less frequent in patients with SARSCoV-2 pneumonia than patients with influenza pneumonia.
- Published
- 2021
171. Additional file 7 of Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial
- Author
-
Benichou, Nicolas, Saïd Lebbah, Hajage, David, Martin-Lefèvre, Laurent, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, De Prost, Nicolas, Lautrette, Alexandre, Bretagnol, Anne, Mayaux, Julien, Nseir, Saad, Megarbane, Bruno, Thirion, Marina, Forel, Jean-Marie, Maizel, Julien, Hodane Yonis, Markowicz, Philippe, Thiery, Guillaume, Schortgen, Frederique, Tubach, Florence, Jean-Damien Ricard, Dreyfuss, Didier, and Gaudry, Stéphane
- Abstract
Additional file 7: Table S5. Possible infectious catheter-related complications according to insertion site and arm of randomization (among patients who underwent RRT and catheter insertion).
- Published
- 2021
- Full Text
- View/download PDF
172. Additional file 1 of Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial
- Author
-
Benichou, Nicolas, Saïd Lebbah, Hajage, David, Martin-Lefèvre, Laurent, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, De Prost, Nicolas, Lautrette, Alexandre, Bretagnol, Anne, Mayaux, Julien, Nseir, Saad, Megarbane, Bruno, Thirion, Marina, Forel, Jean-Marie, Maizel, Julien, Hodane Yonis, Markowicz, Philippe, Thiery, Guillaume, Schortgen, Frederique, Tubach, Florence, Jean-Damien Ricard, Dreyfuss, Didier, and Gaudry, Stéphane
- Abstract
Additional file 1: Table S1. Catheter tip culture at removal, skin cleaning protocol and catheter lock solution according to participating centers.
- Published
- 2021
- Full Text
- View/download PDF
173. Additional file 1 of Handgrip strength to predict extubation outcome: a prospective multicenter trial
- Author
-
Cottereau, Guillaume, Messika, Jonathan, Megarbane, Bruno, Guérin, Laurent, da Silva, Daniel, Bornstain, Caroline, Santos, Matilde, Ricard, Jean-Damien, and Sztrymf, Benjamin
- Abstract
Additional file 1: Table S1. Inclusions distribution among participating centers. Table S2. Baseline characteristics according to extubation outcome. Figure S1. Weaning flowchart. Figure S2. Receiver operating characteristics analysis testing acuity of handgrip to predict extubation outcome.
- Published
- 2021
- Full Text
- View/download PDF
174. Additional file 2 of Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial
- Author
-
Benichou, Nicolas, Saïd Lebbah, Hajage, David, Martin-Lefèvre, Laurent, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, De Prost, Nicolas, Lautrette, Alexandre, Bretagnol, Anne, Mayaux, Julien, Nseir, Saad, Megarbane, Bruno, Thirion, Marina, Forel, Jean-Marie, Maizel, Julien, Hodane Yonis, Markowicz, Philippe, Thiery, Guillaume, Schortgen, Frederique, Tubach, Florence, Jean-Damien Ricard, Dreyfuss, Didier, and Gaudry, Stéphane
- Abstract
Additional file 2: Table S2. Catheter-related bacteremia or fungemia definitions (from Guidelines IDSA 2009, CID 2009 Dec 1 ;49:1-45).
- Published
- 2021
- Full Text
- View/download PDF
175. Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort (vol 25, 177, 2021)
- Author
-
Nseir, Saad Martin-Loeches, Ignacio Povoa, Pedro Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien Tamion, Fabienne Labruyere, Marie Makris, Demosthenes Boulle Geronimi, Claire Pinetonde Chambrun, Marc Nyunga, Martine and Pouly, Olivier Megarbane, Bruno Saade, Anastasia Goma, Gemma and Magira, Eleni Llitjos, Jean-Francois Torres, Antoni and Ioannidou, Iliana Pierre, Alexandre Coelho, Luis Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean-Luc and Voiriot, Guillaume Contou, Damien Beurton, Alexandra Asfar, Pierre Boyer, Alexandre Thille, Arnaud W. Mekontso-Dessap, Armand Tsolaki, Vassiliki Vinsonneau, Christophe Floch, Pierre-Edouard Le Guennec, Loic Ceccato, Adrian Artigas, Antonio Bouchereau, Mathilde Labreuche, Julien Duhamel, Alain Rouze, Anahita CoVAPid Study Grp
- Published
- 2021
176. Variation of drugs involved in acute drug toxicity presentations based on age and sex:an epidemiological approach based on European emergency departments
- Author
-
Miró, Òscar, Waring, William S., Dargan, Paul I., Wood, David M., Dines, Alison M., Yates, Christopher, Giraudon, Isabelle, Moughty, Adrian, O'Connor, Niall, Heyerdahl, Fridtjof, Hovda, Knut E., Vallersnes, Odd M., Paasma, Raido, Pold, Kristiina, Jürgens, Gesche, Megarbane, Bruno, Anand, Jacek S., Liakoni, Evangelia, Liechti, Matthias, Eyer, Florian, Zacharov, Sergej, Caganova, Blazena, Bonnici, Jeffrey, Radenkova-Saeva, Julia, Galicia, Miguel, Miró, Òscar, Waring, William S., Dargan, Paul I., Wood, David M., Dines, Alison M., Yates, Christopher, Giraudon, Isabelle, Moughty, Adrian, O'Connor, Niall, Heyerdahl, Fridtjof, Hovda, Knut E., Vallersnes, Odd M., Paasma, Raido, Pold, Kristiina, Jürgens, Gesche, Megarbane, Bruno, Anand, Jacek S., Liakoni, Evangelia, Liechti, Matthias, Eyer, Florian, Zacharov, Sergej, Caganova, Blazena, Bonnici, Jeffrey, Radenkova-Saeva, Julia, and Galicia, Miguel
- Abstract
Objective: To analyse the relative percentage of acute recreational drug toxicity emergency department (ED) presentations involving the main drug groups according to age and sex and investigate different patterns based on sex and age strata. Methods: We analysed all patients with acute recreational drug toxicity included by the Euro-DEN Plus dataset (22 EDs in 14 European countries) between October 2013 and December 2016 (39 months). Drugs were grouped as: opioids, cocaine, cannabis, amphetamines, gamma-hydroxybutyrate (GHB), hallucinogens, new psychoactive substances (NPS), benzodiazepines and ketamine. Descriptive data by age and sex are presented and compared among age/sex categories and among drug families. Results: Of 17,371 patients were included during the 39-month period, 17,198 (99.0%) had taken at least one of the investigated drugs (median age: 31 years; 23.9% female; ethanol co-ingestion recorded in 41.5%, unknown in 31.2%; multiple drug use in 37.9%). Opioids (in 31.4% of patients) and amphetamines (23.3%) were the most frequently involved and hallucinogens (1.9%) and ketamine (1.7%) the least. Overall, female patients were younger than males, both in the whole cohort (median age 29 vs. 32 years; p < 0.001) and in all drug groups except benzodiazepines (median age 36 vs. 36 years; p = 0.83). The relative proportion of each drug group was different at every age strata and some patterns could be clearly described: cannabis, NPS and hallucinogens were the most common in patients <20 years; amphetamines, ketamine and cocaine in the 20- to 39-year group; GHB/GBL in the 30- to 39-year group; and opioids and benzodiazepines in patients ≥40 years. Ethanol and other drug co-ingestion was more frequent at middle-ages, and multidrug co-ingestion was more common in females than males. Conclusion: Differences in the drugs involved in acute drug toxicity presentations according to age and sex may be relevant for developing drug-prevention and education progr
- Published
- 2021
177. Nouveaux antidotes en toxicologie clinique
- Author
-
Mégarbane, Bruno
- Published
- 2023
- Full Text
- View/download PDF
178. Prognostic factors in non-exertional heatstroke
- Author
-
Hausfater, Pierre, Megarbane, Bruno, Dautheville, Sandrine, Patzak, Anabella, Andronikof, Marc, Santin, Aline, André, Stéphanie, Korchia, Ludovic, Terbaoui, Nabila, Kierzek, Gérald, Doumenc, Benoît, Leroy, Christophe, and Riou, Bruno
- Published
- 2010
- Full Text
- View/download PDF
179. Guidelines for Reporting Case Studies on Extracorporeal Treatments in Poisonings: Methodology
- Author
-
Lavergne, Valéry, Ouellet, Georges, Bouchard, Josée, Galvao, Tais, Kielstein, Jan T., Roberts, Darren M., Kanji, Salmaan, Mowry, James B., Calello, Diane P., Hoffman, Robert S., Gosselin, Sophie, Nolin, Thomas D., Goldfarb, David S., Burdmann, Emmanuel A., Dargan, Paul I., Decker, Brian Scott, Hoegberg, Lotte C., Maclaren, Robert, Megarbane, Bruno, Sowinski, Kevin M., Yates, Christopher, Mactier, Robert, Wiegand, Timothy, and Ghannoum, Marc
- Published
- 2014
- Full Text
- View/download PDF
180. Long-term outcomes and cardiac surgery in critically ill patients with infective endocarditis
- Author
-
Mirabel, Mariana, Sonneville, Romain, Hajage, David, Novy, Emmanuel, Tubach, Florence, Vignon, Philippe, Perez, Pierre, Lavoué, Sylvain, Kouatchet, Achille, Pajot, Olivier, Mekontso-Dessap, Armand, Tonnelier, Jean-Marie, Bollaert, Pierre-Edouard, Frat, Jean-Pierre, Navellou, Jean-Christophe, Hyvernat, Herve, Hssain, Ali Ait, Timsit, Jean-François, Megarbane, Bruno, Wolff, Michel, and Trouillet, Jean-Louis
- Published
- 2014
- Full Text
- View/download PDF
181. High versus Low Blood-Pressure Target in Patients with Septic Shock
- Author
-
Asfar, Pierre, Meziani, Ferhat, Hamel, Jean-François, Grelon, Fabien, Megarbane, Bruno, Anguel, Nadia, Mira, Jean-Paul, Dequin, Pierre-François, Gergaud, Soizic, Weiss, Nicolas, Legay, François, Le Tulzo, Yves, Conrad, Marie, Robert, René, Gonzalez, Frédéric, Guitton, Christophe, Tamion, Fabienne, Tonnelier, Jean-Marie, Guezennec, Pierre, Van Der Linden, Thierry, Vieillard-Baron, Antoine, Mariotte, Eric, Pradel, Gaël, Lesieur, Olivier, Ricard, Jean-Damien, Hervé, Fabien, du Cheyron, Damien, Guerin, Claude, Mercat, Alain, Teboul, Jean-Louis, and Radermacher, Peter
- Published
- 2014
- Full Text
- View/download PDF
182. Prognostic Factors of Severe Bacteraemic Pneumococcal Pneumonia in Critically Ill Immunocompetent Patients: A STREPTOGENE Sub-Study
- Author
-
BELLUT, Hugo, primary, PORCHER, Raphael, additional, VARON, Emmanuelle, additional, ASFAR, Pierre, additional, TULZO, Yves LE, additional, MEGARBANE, Bruno, additional, MATHONNET, Armelle, additional, DUGARD, Anthony, additional, VEINSTEIN, Anne, additional, OUCHENIR, Kader, additional, SIAMI, Shidasp, additional, REIGNIER, Jean, additional, GALBOIS, Arnaud, additional, COUSSON, Joël, additional, PREAU, Sébastien, additional, BALDESI, Olivier, additional, RIGAUD, Jean‑Philippe, additional, SOUWEINE, Bertrand, additional, MISSET, Benoit, additional, JACOBS, Frederic, additional, DEWAVRIN, Florent, additional, MIRA, Jean-Paul, additional, and BEDOS, Jean‑Pierre, additional
- Published
- 2021
- Full Text
- View/download PDF
183. DESIGN AND CONDUCT OF A MULTICENTER RANDOMIZED CLINICAL TRIAL ON THE IMPACT OF A POST-INTENSIVE CARE UNIT MULTIDISCIPLINARY FOLLOW-UP ON THE QUALITY OF LIFE (SUIVI-REA) (Preprint)
- Author
-
Diane, Friedman, primary, Grimaldi, Lamiae, additional, Cariou, Alain, additional, Aegerter, Philippe, additional, Gaudry, Stéphane, additional, Ben Salah, Abdel, additional, Oueslati, Haikel, additional, Megarbane, Bruno, additional, Meunier-Beillard, Nicolas, additional, Quenot, Jean-Pierre, additional, Schwebel, Carole, additional, Jacob, Laurent, additional, Robin Lagandré, Ségloène, additional, Kalfon, Pierre, additional, Sonneville, Romain, additional, Siami, Shidasp, additional, Mazeraud, Aurelien, additional, and Sharshar, Tarek, additional
- Published
- 2021
- Full Text
- View/download PDF
184. Comparison of Circulating Immune Cells Profiles and Kinetics Between Coronavirus Disease 2019 and Bacterial Sepsis*
- Author
-
de Roquetaillade, Charles, primary, Mansouri, Sehmi, additional, Brumpt, Caren, additional, Neuwirth, Marie, additional, Voicu, Sébastian, additional, Le Dorze, Matthieu, additional, Fontaine, Candice, additional, Barthélémy, Romain, additional, Gayat, Etienne, additional, Megarbane, Bruno, additional, Mebazaa, Alexandre, additional, and Chousterman, Benjamin Glenn, additional
- Published
- 2021
- Full Text
- View/download PDF
185. Risk factors associated with COVID-19-associated pulmonary aspergillosis in ICU patients: a French multicentric retrospective cohort
- Author
-
Dellière, Sarah, primary, Dudoignon, Emmanuel, additional, Fodil, Sofiane, additional, Voicu, Sebastian, additional, Collet, Magalie, additional, Oillic, Pierre-Antoine, additional, Salmona, Maud, additional, Dépret, François, additional, Ghelfenstein-Ferreira, Théo, additional, Plaud, Benoit, additional, Chousterman, Benjamin, additional, Bretagne, Stéphane, additional, Azoulay, Elie, additional, Mebazaa, Alexandre, additional, Megarbane, Bruno, additional, and Alanio, Alexandre, additional
- Published
- 2021
- Full Text
- View/download PDF
186. Swallowing disorders as a predictor of unsuccessful extubation: a clinical evaluation
- Author
-
Colonel, Philippe, Houze, Marie Helene, Vert, Helene, Mateo, Joachim, Megarbane, Bruno, Goldgran-Toledano, Dany, Bizouard, Francoise, Hedreul-Vittet, Martine, Baud, Frederic J., Payen, Didier, Vicaut, Eric, and Yelnik, Alain P.
- Subjects
Deglutition disorders -- Research ,Ventilator weaning -- Patient outcomes ,Health ,Health care industry - Published
- 2008
187. Assessment of digoxin antibody use in patients with elevated serum digoxin following chronic or acute exposure
- Author
-
Lapostolle, Frederic, Borron, Stephen W., Verdier, Carine, Arnaud, Fabrice, Couvreur, James, Megarbane, Bruno, Baud, Frederic, and Adnet, Frederic
- Subjects
Antidotes -- Research ,Digoxin -- Complications and side effects ,Poisoning -- Care and treatment ,Immunotoxicology -- Research ,Health care industry - Abstract
Byline: Frederic Lapostolle (1,2), Stephen W. Borron (3), Carine Verdier (1), Fabrice Arnaud (4), James Couvreur (5), Bruno Megarbane (2), Frederic Baud (2), Frederic Adnet (1) Keywords: Digitalis; Poisoning; Antidote; Digitalis antibodies; Immuno-toxicotherapy Abstract: Objective To evaluate the use of antidotal therapy in patients with an elevated digitalis concentration following chronic or acute exposure. Design and setting Retrospective review of patient records over 2 years in 20 city hospitals in France. Patients Overall 838 patients with an elevated serum digitalis concentration (digoxina->a-1.95a-ng/ml or digitoxina->a-23a-ng/ml) were included in the study. Of these, 67 (8%) had received antidotal therapy with Fab fragments. Measurements and results The relationships between previously reported prognostic criteria and use of antidotal therapy were investigated. We identified five independent factors that were associated with the use of antidotal therapy: acute overdose (OR 15.74), Fab fragment availability in the hospital (11.06), serum potassium (1.81), and heart rate (0.96). Mortality was significantly lower in Fab-treated (6%, 4/67) than untreated patients (15%, 117/770). Conclusions Antidotal therapy is underused in patients with an elevated digitalis concentration especially in patients with chronic digitalis exposure. These patients in our series presented a higher mortality rate than patients with acute poisoning. Although they were older and tended to have a history of cardiac disease, they did not differ from patients with acute poisoning with regard to the main severity criteria and prognostic factors. The use of identical criteria for antidotal treatment after acute and chronic poisoning should help optimize outcomes. Fab fragment availability is insufficient in France but ranks only second after type of poisoning (acute or chronic) in the multivariate association with Fab treatment. Author Affiliation: (1) SAMU 93, EA 3409, Hopital Avicenne, 125 rue de Stalingrad, Bobigny, France (2) Toxicological and Intensive Care Unit, Hopital Lariboisiere, Paris, France (3) Emergency Medicine, Department of Surgery, and South Texas Poison Center, University of Texas Health Science Center, TX 78229, San Antonio, USA (4) SAMU 44, Centre Hospitalier Universitaire de Nantes, Nantes, France (5) SAMU 29, Hopital La Cavale, Centre Hospitalier Universitaire de Brest, Brest, France Article History: Registration Date: 11/03/2008 Received Date: 30/06/2006 Accepted Date: 09/03/2008 Online Date: 04/04/2008
- Published
- 2008
188. Femoral vs Jugular venous catheterization and risk of nosocomial events in adults requiring acute renal replacement therapy: a randomized controlled trial
- Author
-
Parienti, Jean-Jacques, Thirion, Marina, Megarbane, Bruno, Souweine, Bertrand, Ouchikhe, Abdelali, Polito, Andrea, Forel, Jean-Marie, Marque, Sophie, Misset, Benoit, Airapetian, Norair, Daurel, Claire, Mira, Jean-Paul, Ramakers, Michel, du Cheyron, Damien, Le Coutour, Xavier, Daubin, Cedric, and Charbonneau, Pierre
- Subjects
Cross infection -- Control ,Nosocomial infections -- Control ,Urinary catheterization -- Evaluation ,Adults -- Health aspects - Abstract
A study was conducted to compare the efficacy of femoral catheterization as against jugular catheterization in the reduction of nonsocomial complications in adults requiring acute renal replacement therapy. Results indicated that femoral catheterization was more effective than jugular catheterization in reducing the risk of infections except in adults with a high body mass index.
- Published
- 2008
189. Venoarterial extracorporeal membrane oxygenation for patients in shock or cardiac arrest secondary to cardiotoxicant poisoning: A cost-effectiveness analysis
- Author
-
St-Onge, Maude, Fan, Eddy, Mégarbane, Bruno, Hancock-Howard, Rebecca, and Coyte, Peter C.
- Published
- 2015
- Full Text
- View/download PDF
190. Mergers and Acquisitions Dynamics in the Biotechnology Industry: What are the Key Drivers for the Genomics Sector?
- Author
-
Amir-Aslani, Arsia and Megarbane, Bruno
- Published
- 2007
- Full Text
- View/download PDF
191. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19:The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial
- Author
-
Angus, Derek C, Derde, Lennie, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen, Beane, Abigail, van Bentum-Puijk, Wilma, Berry, Lindsay, Bhimani, Zahra, Bonten, Marc, Bradbury, Charlotte, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Cheng, Allen C, de Jong, Menno, Detry, Michelle, Estcourt, Lise, Fitzgerald, Mark, Goossens, Herman, Green, Cameron, Haniffa, Rashan, Higgins, Alisa M, Horvat, Christopher, Hullegie, Sebastiaan J, Kruger, Peter, Lamontagne, Francois, Lawler, Patrick R, Linstrum, Kelsey, Litton, Edward, Lorenzi, Elizabeth, Marshall, John, McAuley, Daniel, McGlothin, Anna, McGuinness, Shay, McVerry, Bryan, Montgomery, Stephanie, Mouncey, Paul, Murthy, Srinivas, Nichol, Alistair, Parke, Rachael, Parker, Jane, Rowan, Kathryn, Sanil, Ashish, Santos, Marlene, Saunders, Christina, Seymour, Christopher, Turner, Anne, van de Veerdonk, Frank, Venkatesh, Balasubramanian, Zarychanski, Ryan, Berry, Scott, Lewis, Roger J, McArthur, Colin, Webb, Steven A, Gordon, Anthony C, Writing Committee for the REMAP-CAP Investigators, Angus, Derek, Cheng, Allen, De Jong, Menno, Gordon, Anthony, Lawler, Patrick, Webb, Steve, Campbell, Lewis, Forbes, Andrew, Gattas, David, Heritier, Stephane, Higgins, Lisa, Peake, Sandra, Presneill, Jeffrey, Seppelt, Ian, Trapani, Tony, Young, Paul, Bagshaw, Sean, Daneman, Nick, Ferguson, Niall, Misak, Cheryl, Hullegie, Sebastiaan, Pletz, Mathias, Rohde, Gernot, Rowan, Kathy, Alexander, Brian, Basile, Kim, Girard, Timothy, Huang, David, Vates, Jennifer, Beasley, Richard, Fowler, Robert, McGloughlin, Steve, Morpeth, Susan, Paterson, David, Venkatesh, Bala, Uyeki, Tim, Baillie, Kenneth, Duffy, Eamon, Fowler, Rob, Hills, Thomas, Orr, Katrina, Patanwala, Asad, Tong, Steve, Netea, Mihai, Bihari, Shilesh, Carrier, Marc, Fergusson, Dean, Goligher, Ewan, Haidar, Ghady, Hunt, Beverley, Kumar, Anand, Laffan, Mike, Lawless, Patrick, Lother, Sylvain, McCallum, Peter, Middeldopr, Saskia, McQuilten, Zoe, Neal, Matthew, Pasi, John, Schutgens, Roger, Stanworth, Simon, Turgeon, Alexis, Weissman, Alexandra, Adhikari, Neill, Anstey, Matthew, Brant, Emily, de Man, Angelique, Lamonagne, Francois, Masse, Marie-Helene, Udy, Andrew, Arnold, Donald, Begin, Phillipe, Charlewood, Richard, Chasse, Michael, Coyne, Mark, Cooper, Jamie, Daly, James, Gosbell, Iain, Harvala-Simmonds, Heli, Hills, Tom, MacLennan, Sheila, Menon, David, McDyer, John, Pridee, Nicole, Roberts, David, Shankar-Hari, Manu, Thomas, Helen, Tinmouth, Alan, Triulzi, Darrell, Walsh, Tim, Wood, Erica, Calfee, Carolyn, O’Kane, Cecilia, Shyamsundar, Murali, Sinha, Pratik, Thompson, Taylor, Young, Ian, Bihari, Shailesh, Hodgson, Carol, Laffey, John, McAuley, Danny, Orford, Neil, Neto, Ary, Lewis, Roger, McGlothlin, Anna, Miller, Eliza, Singh, Vanessa, Zammit, Claire, van Bentum Puijk, Wilma, Bouwman, Wietske, Mangindaan, Yara, Parker, Lorraine, Peters, Svenja, Rietveld, Ilse, Raymakers, Kik, Ganpat, Radhika, Brillinger, Nicole, Markgraf, Rene, Ainscough, Kate, Brickell, Kathy, Anjum, Aisha, Lane, Janis-Best, Richards-Belle, Alvin, Saull, Michelle, Wiley, Daisy, Bion, Julian, Connor, Jason, Gates, Simon, Manax, Victoria, van der Poll, Tom, Reynolds, John, van Beurden, Marloes, Effelaar, Evelien, Schotsman, Joost, Boyd, Craig, Harland, Cain, Shearer, Audrey, Wren, Jess, Clermont, Giles, Garrard, William, Kalchthaler, Kyle, King, Andrew, Ricketts, Daniel, Malakoutis, Salim, Marroquin, Oscar, Music, Edvin, Quinn, Kevin, Cate, Heidi, Pearson, Karen, Collins, Joanne, Hanson, Jane, Williams, Penny, Jackson, Shane, Asghar, Adeeba, Dyas, Sarah, Sutu, Mihaela, Murphy, Sheenagh, Williamson, Dawn, Mguni, Nhlanhla, Potter, Alison, Porter, David, Goodwin, Jayne, Rook, Clare, Harrison, Susie, Williams, Hannah, Campbell, Hilary, Lomme, Kaatje, Williamson, James, Sheffield, Jonathan, van’t Hoff, Willian, McCracken, Phobe, Young, Meredith, Board, Jasmin, Mart, Emma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Affleck, Julia, Ramanan, Mahesh, D’Souza, Ramsy, Pateman, Kelsey, Shakih, Arif, Cheung, Winston, Kol, Mark, Wong, Helen, Shah, Asim, Wagh, Atul, Simpson, Joanne, Duke, Graeme, Chan, Peter, Cartner, Brittney, Hunter, Stephanie, Laver, Russell, Shrestha, Tapaswi, Regli, Adrian, Pellicano, Annamaria, McCullough, James, Tallott, Mandy, Kumar, Nikhil, Panwar, Rakshit, Brinkerhoff, Gail, Koppen, Cassandra, Cazzola, Federica, Brain, Matthew, Mineall, Sarah, Fischer, Roy, Biradar, Vishwanath, Soar, Natalie, White, Hayden, Estensen, Kristen, Morrison, Lynette, Smith, Joanne, Cooper, Melanie, Health, Monash, Shehabi, Yahya, Al-Bassam, Wisam, Hulley, Amanda, Whitehead, Christina, Lowrey, Julie, Gresha, Rebecca, Walsham, James, Meyer, Jason, Harward, Meg, Venz, Ellen, Williams, Patricia, Kurenda, Catherine, Smith, Kirsy, Smith, Margaret, Garcia, Rebecca, Barge, Deborah, Byrne, Deborah, Byrne, Kathleen, Driscoll, Alana, Fortune, Louise, Janin, Pierre, Yarad, Elizabeth, Hammond, Naomi, Bass, Frances, Ashelford, Angela, Waterson, Sharon, Wedd, Steve, McNamara, Robert, Buhr, Heidi, Coles, Jennifer, Schweikert, Sacha, Wibrow, Bradley, Rauniyar, Rashmi, Myers, Erina, Fysh, Ed, Dawda, Ashlish, Mevavala, Bhaumik, Litton, Ed, Ferrier, Janet, Nair, Priya, Buscher, Hergen, Reynolds, Claire, Santamaria, John, Barbazza, Leanne, Homes, Jennifer, Smith, Roger, Murray, Lauren, Brailsford, Jane, Forbes, Loretta, Maguire, Teena, Mariappa, Vasanth, Smith, Judith, Simpson, Scott, Maiden, Matthew, Bone, Allsion, Horton, Michelle, Salerno, Tania, Sterba, Martin, Geng, Wenli, Depuydt, Pieter, De Waele, Jan, De Bus, Liesbet, Fierens, Jan, Bracke, Stephanie, Reeve, Brenda, Dechert, William, Chassé, Michaël, Carrier, François Martin, Boumahni, Dounia, Benettaib, Fatna, Ghamraoui, Ali, Bellemare, David, Cloutier, Ève, Francoeur, Charles, Lamontagne, François, D’Aragon, Frédérick, Carbonneau, Elaine, Leblond, Julie, Vazquez-Grande, Gloria, Marten, Nicole, Wilson, Maggie, Albert, Martin, Serri, Karim, Cavayas, Alexandros, Duplaix, Mathilde, Williams, Virginie, Rochwerg, Bram, Karachi, Tim, Oczkowski, Simon, Centofanti, John, Millen, Tina, Duan, Erick, Tsang, Jennifer, Patterson, Lisa, English, Shane, Watpool, Irene, Porteous, Rebecca, Miezitis, Sydney, McIntyre, Lauralyn, Brochard, Laurent, Burns, Karen, Sandhu, Gyan, Khalid, Imrana, Binnie, Alexandra, Powell, Elizabeth, McMillan, Alexandra, Luk, Tracy, Aref, Noah, Andric, Zdravko, Cviljevic, Sabina, Đimoti, Renata, Zapalac, Marija, Mirković, Gordan, Baršić, Bruno, Kutleša, Marko, Kotarski, Viktor, Vujaklija Brajković, Ana, Babel, Jakša, Sever, Helena, Dragija, Lidija, Kušan, Ira, Vaara, Suvi, Pettilä, Leena, Heinonen, Jonna, Kuitunen, Anne, Karlsson, Sari, Vahtera, Annukka, Kiiski, Heikki, Ristimäki, Sanna, Azaiz, Amine, Charron, Cyril, Godement, Mathieu, Geri, Guillaume, Vieillard-Baron, Antoine, Pourcine, Franck, Monchi, Mehran, Luis, David, Mercier, Romain, Sagnier, Anne, Verrier, Nathalie, Caplin, Cecile, Siami, Shidasp, Aparicio, Christelle, Vautier, Sarah, Jeblaoui, Asma, Fartoukh, Muriel, Courtin, Laura, Labbe, Vincent, Leparco, Cécile, Muller, Grégoire, Nay, Mai-Anh, Kamel, Toufik, Benzekri, Dalila, Jacquier, Sophie, Mercier, Emmanuelle, Chartier, Delphine, Salmon, Charlotte, Dequin, PierreFrançois, Schneider, Francis, Morel, Guillaume, L’Hotellier, Sylvie, Badie, Julio, Berdaguer, Fernando Daniel, Malfroy, Sylvain, Mezher, Chaouki, Bourgoin, Charlotte, Megarbane, Bruno, Voicu, Sebastian, Deye, Nicolas, Malissin, Isabelle, Sutterlin, Laetitia, Guitton, Christophe, Darreau, Cédric, Landais, Mickaël, Chudeau, Nicolas, Robert, Alain, Moine, Pierre, Heming, Nicholas, Maxime, Virginie, Bossard, Isabelle, Nicholier, Tiphaine Barbarin, Colin, Gwenhael, Zinzoni, Vanessa, Maquigneau, Natacham, Finn, André, Kreß, Gabriele, Hoff, Uwe, Friedrich Hinrichs, Carl, Nee, Jens, Hagel, Stefan, Ankert, Juliane, Kolanos, Steffi, Bloos, Frank, Petros, Sirak, Pasieka, Bastian, Kunz, Kevin, Appelt, Peter, Schütze, Bianka, Kluge, Stefan, Nierhaus, Axel, Jarczak, Dominik, Roedl, Kevin, Weismann, Dirk, Frey, Anna, Klinikum Neukölln, Vivantes, Reill, Lorenz, Distler, Michael, Maselli, Astrid, Bélteczki, János, Magyar, István, Fazekas, Ágnes, Kovács, Sándor, Szőke, Viktória, Szigligeti, Gábor, Leszkoven, János, Collins, Daniel, Breen, Patrick, Frohlich, Stephen, Whelan, Ruth, McNicholas, Bairbre, Scully, Michael, Casey, Siobhan, Kernan, Maeve, Doran, Peter, O’Dywer, Michael, Smyth, Michelle, Hayes, Leanne, Hoiting, Oscar, Peters, Marco, Rengers, Els, Evers, Mirjam, Prinssen, Anton, Bosch Ziekenhuis, Jeroen, Simons, Koen, Rozendaal, Wim, Polderman, F, de Jager, P, Moviat, M, Paling, A, Salet, A, Rademaker, Emma, Peters, Anna Linda, de Jonge, E, Wigbers, J, Guilder, E, Butler, M, Cowdrey, Keri-Anne, Newby, Lynette, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, Ritzema Carter, Jay, Henderson, Seton, Van Der Heyden, Kym, Mehrtens, Jan, Williams, Tony, Kazemi, Alex, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Everitt, Robert, Russell, Robert, Hacking, Danielle, Buehner, Ulrike, Williams, Erin, Browne, Troy, Grimwade, Kate, Goodson, Jennifer, Keet, Owen, Callender, Owen, Martynoga, Robert, Trask, Kara, Butler, Amelia, Schischka, Livia, Young, Chelsea, Lesona, Eden, Olatunji, Shaanti, Robertson, Yvonne, José, Nuno, Amaro dos Santos Catorze, Teodoro, de Lima Pereira, Tiago Nuno Alfaro, Neves Pessoa, Lucilia Maria, Castro Ferreira, Ricardo Manuel, Pereira Sousa Bastos, Joana Margarida, Aysel Florescu, Simin, Stanciu, Delia, Zaharia, Miahela Florentina, Kosa, Alma Gabriela, Codreanu, Daniel, Marabi, Yaseen, Al Qasim, Eman, Moneer Hagazy, Mohamned, Al Swaidan, Lolowa, Arishi, Hatim, Muñoz-Bermúdez, Rosana, Marin-Corral, Judith, Salazar Degracia, Anna, Parrilla Gómez, Francisco, Mateo López, Maria Isabel, Rodriguez Fernandez, Jorge, Cárcel Fernández, Sheila, Carmona Flores, Rosario, León López, Rafael, de la Fuente Martos, Carmen, Allan, Angela, Polgarova, Petra, Farahi, Neda, McWilliam, Stephen, Hawcutt, Daniel, Rad, Laura, O’Malley, Laura, Whitbread, Jennifer, Kelsall, Olivia, Wild, Laura, Thrush, Jessica, Wood, Hannah, Austin, Karen, Donnelly, Adrian, Kelly, Martin, O’Kane, Sinéad, McClintock, Declan, Warnock, Majella, Johnston, Paul, Gallagher, Linda Jude, Mc Goldrick, Clare, Mc Master, Moyra, Strzelecka, Anna, Jha, Rajeev, Kalogirou, Michael, Ellis, Christine, Krishnamurthy, Vinodh, Deelchand, Vashish, Silversides, Jon, McGuigan, Peter, Ward, Kathryn, O’Neill, Aisling, Finn, Stephanie, Phillips, Barbara, Mullan, Dee, Oritz-Ruiz de Gordoa, Laura, Thomas, Matthew, Sweet, Katie, Grimmer, Lisa, Johnson, Rebekah, Pinnell, Jez, Robinson, Matt, Gledhill, Lisa, Wood, Tracy, Morgan, Matt, Cole, Jade, Hill, Helen, Davies, Michelle, Antcliffe, David, Templeton, Maie, Rojo, Roceld, Coghlan, Phoebe, Smee, Joanna, Mackay, Euan, Cort, Jon, Whileman, Amanda, Spencer, Thomas, Spittle, Nick, Kasipandian, Vidya, Patel, Amit, Allibone, Suzanne, Genetu, Roman Mary, Ramali, Mohamed, Ghosh, Alison, Bamford, Peter, London, Emily, Cawley, Kathryn, Faulkner, Maria, Jeffrey, Helen, Smith, Tim, Brewer, Chris, Gregory, Jane, Limb, James, Cowton, Amanda, O’Brien, Julie, Nikitas, Nikitas, Wells, Colin, Lankester, Liana, Pulletz, Mark, Birch, Jenny, Wiseman, Sophie, Horton, Sarah, Alegria, Ana, Turki, Salah, Elsefi, Tarek, Crisp, Nikki, Allen, Louise, McCullagh, Iain, Robinson, Philip, Hays, Carole, Babio-Galan, Maite, Stevenson, Hannah, Khare, Divya, Pinder, Meredith, Selvamoni, Selvin, Gopinath, Amitha, Pugh, Richard, Menzies, Daniel, Mackay, Callum, Allan, Elizabeth, Davies, Gwyneth, Puxty, Kathryn, McCue, Claire, Cathcart, Susanne, Hickey, Naomi, Ireland, Jane, Yusuff, Hakeem, Isgro, Graziella, Brightling, Chris, Bourne, Michelle, Craner, Michelle, Watters, Malcolm, Prout, Rachel, Davies, Louisa, Pegler, Suzannah, Kyeremeh, Lynsey, Arbane, Gill, Wilson, Karen, Gomm, Linda, Francia, Federica, Brett, Stephen, Sousa Arias, Sonia, Elin Hall, Rebecca, Budd, Joanna, Small, Charlotte, Birch, Janine, Collins, Emma, Henning, Jeremy, Bonner, Stephen, Hugill, Keith, Cirstea, Emanuel, Wilkinson, Dean, Karlikowski, Michal, Sutherland, Helen, Wilhelmsen, Elva, Woods, Jane, North, Julie, Sundaran, Dhinesh, Hollos, Laszlo, Coburn, Susan, Walsh, Joanne, Turns, Margaret, Hopkins, Phil, Smith, John, Noble, Harriet, Depante, Maria Theresa, Clarey, Emma, Laha, Shondipon, Verlander, Mark, Williams, Alexandra, Huckle, Abby, Hall, Andrew, Cooke, Jill, Gardiner-Hill, Caroline, Maloney, Carolyn, Qureshi, Hafiz, Flint, Neil, Nicholson, Sarah, Southin, Sara, Nicholson, Andrew, Borgatta, Barbara, Turner-Bone, Ian, Reddy, Amie, Wilding, Laura, Chamara Warnapura, Loku, Agno Sathianathan, Ronan, Golden, David, Hart, Ciaran, Jones, Jo, Bannard-Smith, Jonathan, Henry, Joanne, Birchall, Katie, Pomeroy, Fiona, Quayle, Rachael, Makowski, Arystarch, Misztal, Beata, Ahmed, Iram, KyereDiabour, Thyra, Naiker, Kevin, Stewart, Richard, Mwaura, Esther, Mew, Louise, Wren, Lynn, Willams, Felicity, Innes, Richard, Doble, Patricia, Hutter, Joanne, Shovelton, Charmaine, Plumb, Benjamin, Szakmany, Tamas, Hamlyn, Vincent, Hawkins, Nancy, Lewis, Sarah, Dell, Amanda, Gopal, Shameer, Ganguly, Saibal, Smallwood, Andrew, Harris, Nichola, Metherell, Stella, Lazaro, Juan Martin, Newman, Tabitha, Fletcher, Simon, Nortje, Jurgens, Fottrell-Gould, Deirdre, Randell, Georgina, Zaman, Mohsin, Elmahi, Einas, Jones, Andrea, Hall, Kathryn, Mills, Gary, Ryalls, Kim, Bowler, Helen, Sall, Jas, Bourne, Richard, Borrill, Zoe, Duncan, Tracey, Lamb, Thomas, Shaw, Joanne, Fox, Claire, Moreno Cuesta, Jeronimo, Xavier, Kugan, Purohit, Dharam, Elhassan, Munzir, Bakthavatsalam, Dhanalakshmi, Rowland, Matthew, Hutton, Paula, Bashyal, Archana, Davidson, Neil, Hird, Clare, Chhablani, Manish, Phalod, Gunjan, Kirkby, Amy, Archer, Simon, Netherton, Kimberley, Reschreiter, Henrik, Camsooksai, Julie, Patch, Sarah, Jenkins, Sarah, Pogson, David, Rose, Steve, Daly, Zoe, Brimfield, Lutece, Claridge, Helen, Parekh, Dhruv, Bergin, Colin, Bates, Michelle, Dasgin, Joanne, McGhee, Christopher, Sim, Malcolm, Hay, Sophie Kennedy, Henderson, Steven, Phull, Mandeep-Kaur, Zaidi, Abbas, Pogreban, Tatiana, Rosaroso, Lace Paulyn, Harvey, Daniel, Lowe, Benjamin, Meredith, Megan, Ryan, Lucy, Hormis, Anil, Walker, Rachel, Collier, Dawn, Kimpton, Sarah, Oakley, Susan, Rooney, Kevin, Rodden, Natalie, Hughes, Emma, Thomson, Nicola, McGlynn, Deborah, Walden, Andrew, Jacques, Nicola, Coles, Holly, Tilney, Emma, Vowell, Emma, Schuster-Bruce, Martin, Pitts, Sally, Miln, Rebecca, Purandare, Laura, Vamplew, Luke, Spivey, Michael, Bean, Sarah, Burt, Karen, Moore, Lorraine, Day, Christopher, Gibson, Charly, Gordon, Elizabeth, Zitter, Letizia, Keenan, Samantha, Baker, Evelyn, Cherian, Shiney, Cutler, Sean, Roynon-Reed, Anna, Harrington, Kate, Raithatha, Ajay, Bauchmuller, Kris, Ahmad, Norfaizan, Grecu, Irina, Trodd, Dawn, Martin, Jane, Wrey Brown, Caroline, Arias, Ana-Marie, Craven, Thomas, Hope, David, Singleton, Jo, Clark, Sarah, Rae, Nicola, Welters, Ingeborg, Hamilton, David Oliver, Williams, Karen, Waugh, Victoria, Shaw, David, Puthucheary, Zudin, Martin, Timothy, Santos, Filipa, Uddin, Ruzena, Somerville, Alastair, Tatham, Kate Colette, Jhanji, Shaman, Black, Ethel, Dela Rosa, Arnold, Howle, Ryan, Tully, Redmond, Drummond, Andrew, Dearden, Joy, Philbin, Jennifer, Munt, Sheila, Vuylsteke, Alain, Chan, Charles, Victor, Saji, Matsa, Ramprasad, Gellamucho, Minerva, Creagh-Brown, Ben, Tooley, Joe, Montague, Laura, De Beaux, Fiona, Bullman, Laetitia, Kersiake, Ian, Demetriou, Carrie, Mitchard, Sarah, Ramos, Lidia, White, Katie, Donnison, Phil, Johns, Maggie, Casey, Ruth, Mattocks, Lehentha, Salisbury, Sarah, Dark, Paul, Claxton, Andrew, McLachlan, Danielle, Slevin, Kathryn, Lee, Stephanie, Hulme, Jonathan, Joseph, Sibet, Kinney, Fiona, Senya, Ho Jan, Oborska, Aneta, Kayani, Abdul, Hadebe, Bernard, Orath Prabakaran, Rajalakshmi, Nichols, Lesley, Thomas, Matt, Worner, Ruth, Faulkner, Beverley, Gendall, Emma, Hayes, Kati, Hamilton-Davies, Colin, Chan, Carmen, Mfuko, Celina, Abbass, Hakam, Mandadapu, Vineela, Leaver, Susannah, Forton, Daniel, Patel, Kamal, Paramasivam, Elankumaran, Powell, Matthew, Gould, Richard, Wilby, Elizabeth, Howcroft, Clare, Banach, Dorota, Fernández de Pinedo Artaraz, Ziortza, Cabreros, Leilani, White, Ian, Croft, Maria, Holland, Nicky, Pereira, Rita, Zaki, Ahmed, Johnson, David, Jackson, Matthew, Garrard, Hywel, Juhaz, Vera, Roy, Alistair, Rostron, Anthony, Woods, Lindsey, Cornell, Sarah, Pillai, Suresh, Harford, Rachel, Rees, Tabitha, Ivatt, Helen, Sundara Raman, Ajay, Davey, Miriam, Lee, Kelvin, Barber, Russell, Chablani, Manish, Brohi, Farooq, Jagannathan, Vijay, Clark, Michele, Purvis, Sarah, Wetherill, Bill, Dushianthan, Ahilanandan, Cusack, Rebecca, de Courcy-Golder, Kim, Smith, Simon, Jackson, Susan, Attwood, Ben, Parsons, Penny, Page, Valerie, Zhao, Xiao Bei, Oza, Deepali, Rhodes, Jonathan, Anderson, Tom, Morris, Sheila, Xia Le Tai, Charlotte, Thomas, Amy, Keen, Alexandra, Digby, Stephen, Cowley, Nicholas, Southern, David, Reddy, Harsha, Campbell, Andy, Watkins, Claire, Smuts, Sara, Touma, Omar, Barnes, Nicky, Alexander, Peter, Felton, Tim, Ferguson, Susan, Sellers, Katharine, Bradley-Potts, Joanne, Yates, David, Birkinshaw, Isobel, Kell, Kay, Marshall, Nicola, Carr-Knott, Lisa, Writing Committee for the REMAP-CAP Investigators, Menon, David [0000-0002-3228-9692], Apollo - University of Cambridge Repository, Medical Microbiology and Infection Prevention, and AII - Infectious diseases
- Subjects
Male ,Hydrocortisone ,Anti-Inflammatory Agents ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,01 natural sciences ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,Adrenal Cortex Hormones ,Clinical endpoint ,Medicine ,030212 general & internal medicine ,Hydrocortisone/administration & dosage ,Original Investigation ,2. Zero hunger ,Mortality rate ,Shock ,Covid19 ,General Medicine ,Middle Aged ,Intensive care unit ,3. Good health ,Intensive Care Units ,Treatment Outcome ,Early Termination of Clinical Trials ,Corticosteroid ,Female ,Coronavirus Infections ,medicine.drug ,Adult ,medicine.medical_specialty ,Respiration, Artificial/statistics & numerical data ,medicine.drug_class ,Anti-Inflammatory Agents/administration & dosage ,Pneumonia, Viral ,UNCOVER ,Adrenal Cortex Hormones/therapeutic use ,03 medical and health sciences ,Betacoronavirus ,All institutes and research themes of the Radboud University Medical Center ,Internal medicine ,Humans ,0101 mathematics ,Adverse effect ,Pandemics ,business.industry ,SARS-CoV-2 ,010102 general mathematics ,COVID-19 ,Odds ratio ,Coronavirus Infections/drug therapy ,Pneumonia, Viral/drug therapy ,Respiration, Artificial ,COVID-19 Drug Treatment ,Shock/drug therapy ,Human medicine ,business - Abstract
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020.Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108).Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%).Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively.Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions.Trial Registration: ClinicalTrials.gov Identifier: NCT02735707.
- Published
- 2020
- Full Text
- View/download PDF
192. Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU
- Author
-
Blet, Alice, De Roquetaillade, Charles, Hartmann, Oliver, Struck, Joachim, Mebazaa, Alexandre, Chousterman, Benjamin Glenn, Laterre, Pierre François, Berghe, Caroline, Dujardin, Marie France, Renard, Suzanne, Wittebole, Xavier, Collienne, Christine, Zapatero, Diego Castanares, Dugernier, Thierry, Vinetti, Marco, De Schryver, Nicolas, Thirifays, Anne, Mairesse, Jacques, Huberlant, Vincent, Petre, Hélène, Buelens, Isabelle, Henin, Pierre, Trine, Hugues, Laurent, Yves, Sébastien, Loix, Geukens, Paul, Kehl, Laurent, François, Bruno, Vignon, Philippe, Pichon, Nicolas, Begot, Emmanuelle, Fedou, Anne Laure, Chapellas, Catherine, Galy, Antoine, Rodier, Nicolas, Baudrillart, Ludmilla, Nouaille, Michelle, Laleu, Séverine, Mancia, Claire, Daix, Thomas, Bourzeix, Paul, Herafa, Isabelle, Duchambon, Anne Aurore, Lascarrou, Jean Baptiste, Fiancette, Maud, Colin, Gwenhael, Henry-Lagarrigue, Matthieu, Lacherade, Jean Claude, Lebert, Christine, Martin-Levfèvre, Laurent, Vinatier, Isabelle, Yehia, Aihem, Bachoumas, Konstantinos, Joret, Aurélie, Reignier, Jean, Rousseau, Cécille, Maquigneau, Natacha, Alcourt, Yolaine, Zinzonni, Vanessa Erragne, Deschamps, Angélique, Robert, Angelina, Mercier, Emmanuelle, Simeon-Vieules, Véronique, Aubrey, Aurélie, Mabilat, Christine, Garot, Denis, Ehrmann, Stephan, Legras, Annick, Jouan, Youenn, Dequin, Pierre François, Guillon, Antoine, Bodet-Contentin, Laetitia, Rouve, Emmannuelle, Salmon, Charlotte, Brick, Lysiane, Massat, Stéphanie, Desachy, Arnaud, Fally, Marie Anne, Robin, Laurence, Cracco, Christophe, Lafon, Charles, Calvat, Sylvie, Rouleau, Stéphane, Schnell, David, Lasocki, Sigismond, Fesard, Philippe, Leblanc, Damien, Bouhours, Guillaume, Chassier, Claire, Conte, Mathieu, Gaillard, Thomas, Denou, Floriane, Kerymel, Mathieu, Guyon, Marion, Loiez, Anthéa, Lebreton, Stéphanie, Meziani, Ferhat, Allam, Hayat, Chenaf, Samir, Rahmani, Hassène, Heenen, Sarah, Kummerlen, Christine, Delabranche, Xavier, Boivin, Alexandra, Clere-Jehl, Raphaël, Rabouël, Yannick, Pottecher, Julien, Bayer, Sophie, Metzger, Catherine, Hecketsweiler, Stéphane, Ludes, Pierre Olivier, Besancenot, Hortense, Dhif, Nadia, Freys, Guy, Lessinger, Jean Marc, Launoy, Anne, Ruimy, Aude, Meyer, Alain, Szozot, M., Deye, Nicolas, Gayat, Etienne, Fournier, Marie Céline, Abroug, Sarra, Louadah, Badr, Feliot, Elodie, Voicu, Sebastian, Malissin, Isabelle, Megarbane, Bruno, Manivet, Philippe, Victori, Gardianot, Kelly, Da Silva, La Foucher, Béatrice, Pierre, Valérie, Kerdjana, Lamia, Beeken, Thomas, Goury, Antoine, Garcon, Pierre, Gaugain, Samuel, Huot, Benjamin, Barthelemy, Romain, Soyer, Benjamin, Jacob, Laurent, Legrand, Matthieu, Fourniar, Marie Céline, Bonnet, Francine, Legall, Chloé, Oueslati, Haikel, Cupaciu, Alexandru, Manivat, Philippe, Louadeh, Badr, Sonneville, Romain, Letrou, Sophie, Bouadma, Lila, Mourvillier, Bruno, Deiler, Véronique, Magalhaes, Eric, Neuville, Mathilde, Timsit, Jean François, Radjou, Aguila, Gaudry, Stéphane, Dubief, Emeline, Messika, Jonathan, La Combe, Béatrice, Roux, Damien, Berquier, Guillaume, Laissi, Mohamed, Ricard, Jean Damien, Constantin, Jean Michel, Perbet, Sebastien, Delmas, Julie, Pascal, Julien, Cayot, Sophie, Guerin, Renaud, Jabaudon, Matthieu, Roszyk, Laurence, Rolhion, Christine, Bourdier, Justine, Lematte, Mathilde, Gouhier, Charlène, Verlhac, Camille, Godet, Thomas, Radji, Sophiano, Caumon, Elodie, Thibault, Sandrine, Marx, Nikolaus, Schuerholz, Tobias, Pezechk, Jessica, Feld, Florian, Brülls, Christian, Beeker, Thorben, Simon, Tim Philipp, Deisz, Robert, Schindler, Achim, Meier, Bianca, Janisch, Thorsten, Hohn, Andreas, Schedler, Dirk, Wetsch, Wolfgang, Schröder, Daniel, Meier-Hellmann, Andreas, Lucht, Alexander, Henker, Robert, Römmer, Magdalena, Meinig, Torsten, Zacharowski, Kai D., Meybohm, Patrick, Lindau, Simone, Mutlak, Haitham, Kluge, Stefan, Ringeis, Grit, Füllekrug, Birgit, Singer, Brigitte, Nierhaus, Axel, Bangert, Katrin, De Heer, Geraldine, Frings, Daniel, Fuhrmann, Valentin, Müller, Jakob, Schreiber, Jörg, Sensen, Barbara, Siedler, Stephanie, Siewecke, Annekatrin, Söffker, Gerold, Wichmann, Dominic, Kerinn, Mélanie, Jaschinski, Ulrich, Kreuser, Ilse, Zanquila, Marlene, Kortgen, Andreas, Bloos, Frank, Gonnert, Falk, Thomas-Rüddel, Daniel, Haucke, Anja, Kolanos, Steffi, Kohlberg, Karina Knuhr, Bloos, Petra, Schwope, Katrin, Di Somma, Salvatore, Rossella, Marino, Russo, Veronica, Simona, Santarelli, Bartoli, Christopher, Navarin, Sylvia, Bongiovanni, Cristina, Orru, Michela, Quatrocchi, Daniela, Zoccoli, Giada, Varchetta, Antonella, Antonelli, Massimo, De Pascale, Gennaro, Vallecoccia, Maria Sole, Cutuli, Salvatore Lucio, Digravio, Valentina, Quattrochi, Daniela, D'Arrigo, Sonia, Leone, Filippo Elvino, Beishuizen, Bert, Rinket, Martin, Border, Natalie, Bos-Burgmeijer, Mariska, Braad, Astrid, Papendorp, S., Vermeijden, J., Pickkers, Peter, Van De A, Marieke, Van Wezel, Helen, Heunks, Leo, Bordar, Natalie, Luijten-Arts, Chantal, Hoedemaekers, Astrid, Van Der Hoeven, Hans, Roovers, Noortje, Hemelaar, Pleun, Intensive care medicine, ACS - Pulmonary hypertension & thrombosis, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, and UCL - (SLuc) Service de soins intensifs
- Subjects
Male ,medicine.medical_specialty ,Multiple Organ Failure ,MEDLINE ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Critical Care and Intensive Care Medicine ,Sepsis ,03 medical and health sciences ,Adrenomedullin ,0302 clinical medicine ,Belgium ,Germany ,medicine ,Research Letter ,Humans ,Lactic Acid ,Hospital Mortality ,Prospective Studies ,Prospective cohort study ,Aged ,Netherlands ,Proportional Hazards Models ,Chi-Square Distribution ,business.industry ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,Length of Stay ,Middle Aged ,medicine.disease ,Prognosis ,Shock, Septic ,Survival Analysis ,3. Good health ,Hospitalization ,Patient Outcome Assessment ,Intensive Care Units ,030228 respiratory system ,Italy ,Shock (circulatory) ,Emergency medicine ,Female ,France ,medicine.symptom ,business ,Biomarkers - Abstract
Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial.AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock.Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8).AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial.ClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015.
- Published
- 2020
- Full Text
- View/download PDF
193. Additional file 2 of Impact of take-home messages written into slide presentations delivered during lectures on the retention of messages and the residents’ knowledge: a randomized controlled study
- Author
-
Lautrette, Alexandre, Boyer, Alexandre, Gruson, Didier, Argaud, Laurent, Schwebel, Carole, Tardy, Bernard, Vignon, Philippe, Megarbane, Bruno, Schoeffler, Pierre, Chabrot, Pascal, Schmidt, Jeannot, Boirie, Yves, Guerin, Claude, Darmon, Michaël, Kada Klouche, Souweine, Bertrand, Dellamonica, Jean, and Pereira, Bruno
- Subjects
Data_FILES - Abstract
Additional file 2. Examples of Multiple Choice Questions.
- Published
- 2020
- Full Text
- View/download PDF
194. Additional file 1 of Impact of take-home messages written into slide presentations delivered during lectures on the retention of messages and the residents’ knowledge: a randomized controlled study
- Author
-
Lautrette, Alexandre, Boyer, Alexandre, Gruson, Didier, Argaud, Laurent, Schwebel, Carole, Tardy, Bernard, Vignon, Philippe, Megarbane, Bruno, Schoeffler, Pierre, Chabrot, Pascal, Schmidt, Jeannot, Boirie, Yves, Guerin, Claude, Darmon, Michaël, Kada Klouche, Souweine, Bertrand, Dellamonica, Jean, and Pereira, Bruno
- Subjects
Data_FILES ,ComputingMilieux_COMPUTERSANDEDUCATION ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Abstract
Additional file 1. List of lectures.
- Published
- 2020
- Full Text
- View/download PDF
195. Additional file 3 of Impact of take-home messages written into slide presentations delivered during lectures on the retention of messages and the residents’ knowledge: a randomized controlled study
- Author
-
Lautrette, Alexandre, Boyer, Alexandre, Gruson, Didier, Argaud, Laurent, Schwebel, Carole, Tardy, Bernard, Vignon, Philippe, Megarbane, Bruno, Schoeffler, Pierre, Chabrot, Pascal, Schmidt, Jeannot, Boirie, Yves, Guerin, Claude, Darmon, Michaël, Kada Klouche, Souweine, Bertrand, Dellamonica, Jean, and Pereira, Bruno
- Subjects
GeneralLiterature_MISCELLANEOUS - Abstract
Additional file 3. Timing of the study (Figure). Legend: THM, take-home message; MCQ: multiple choice question.
- Published
- 2020
- Full Text
- View/download PDF
196. Emergency feasibility in medical intensive care unit of extracorporeal life support for refractory cardiac arrest
- Author
-
Megarbane, Bruno, Leprince, Pascal, Deye, Nicolas, Resiere, Dabor, Guerrier, Gilles, Rettab, Samia, Theodore, Jonathan, Karyo, Souheil, Gandjbakhch, Iradj, and Baud, Frederic J.
- Subjects
Intensive care units -- Health aspects ,Cardiopulmonary bypass -- Health aspects ,Cardiac arrest -- Care and treatment ,Health care industry - Abstract
Objective: To report the feasibility, complications, and outcomes of emergency extracorporeal life support (ECLS) in refractory cardiac arrests in medical intensive care unit (ICU). Design and setting: Prospective cohort study in the medical ICU in a university hospital in collaboration with the cardiosurgical team of a neighboring hospital. Patients: Seventeen patients (poisonings: 12/17) admitted over a 2-year period for cardiac arrest unresponsive to cardiopulmonary resuscitation (CPR) and advanced cardiac life support, without return of spontaneous circulation. Interventions: ECLS femoral implantation under continuous cardiac massage, using a centrifugal pump connected to a hollow-fiber membrane oxygenator. Measurements and results: Stable ECLS was achieved in 14 of 17 patients. Early complications included massive transfusions (n = 8) and the need for surgical revision at the cannulation site for bleeding (n = 1). Four patients (24%) survived at medical ICU discharge. Deaths resulted from multiorgan failure (n = 8), thoracic bleeding (n = 2), severe sepsis (n = 2), and brain death (n = 1). Massive hemorrhagic pulmonary edema during CPR (n = 5) and major capillary leak syndrome (n = 6) were observed. Three cardiotoxic-poisoned patients (18%, CPR duration: 30, 100, and 180 min) were alive at 1-year follow-up without sequelae. Two of these patients survived despite elevated plasma lactate concentrations before cannulation (39.0 and 20.0 mmol/l). ECLS was associated with a significantly lower ICU mortality rate than that expected from the Simplified Acute Physiology Score II (91.9%) and lower than the maximum Sequential Organ Failure Assessment score (> 90%). Conclusions: Emergency ECLS is feasible in medical ICU and should be considered as a resuscitative tool for selected patients suffering from refractory cardiac arrest. Keywords Cardiac arrest * Cardiopulmonary resuscitation * Extracorporeal life support * Feasibility * Poisoning * Medical intensive care unit, Introduction Cardiac arrest is a major worldwide public health concern [1]. Survival rate remains very low despite early access to emergency medical care, cardiopulmonary resuscitation (CPR), defibrillation, and advanced cardiac [...]
- Published
- 2007
- Full Text
- View/download PDF
197. A communication strategy and brochure for relatives of patients dying in the ICU
- Author
-
Lautrette, Alexandre, Megarbane, Bruno, Chevret, Sylvie, Joly, Luc Marie, and Darmon, Michael
- Subjects
Health risk communication -- Evaluation ,Physician and patient - Abstract
A randomized, controlled trial was conducted to evaluate the effect of a proactive communication strategy that included an end-of-life conference and provision of a brochure on bereavement to relatives of patients dying in the intensive care unit (ICU). Results indicated that the proactive strategy resulting in longer meetings and more time for family members to talk and express their feelings may lessen the burden of bereavement.
- Published
- 2007
198. Relative Affinity M Constant of Adult and Fetal Hemoglobin for Carbon Monoxide in Humans: a Systematic Review and Meta-Analysis
- Author
-
UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service des urgences, Delvau, Nicolas, Penaloza-Baeza, Andrea, Liistro, Giuseppe, Thys, Frédéric, Megarbane, Bruno, Hantson, Philippe, Roy, Pierre-Marie, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service des urgences, Delvau, Nicolas, Penaloza-Baeza, Andrea, Liistro, Giuseppe, Thys, Frédéric, Megarbane, Bruno, Hantson, Philippe, and Roy, Pierre-Marie
- Abstract
The Haldane M constant represents the ratio of oxygen/carbon monoxide affinity to hemoglobin. Findings on M values appear to be quite variable among studies. A systematic review and a meta-analysis were conducted to set a reference of human M values according to experimental conditions. The searched included all the relevant articles published from 1985 to January 2016 and extracted from the major electronic libraries database (PubMed/Embase/JSTOR). For each article, the following items were collected: age, temperature, pH, atmospheric pressure, 2,3-diphosphoglycerate (2,3-DPG) or methemoglobin levels, and hemoglobin type. Statistical analyses were performed using JMP®Pro12 software. Among the 1.683 articles analyzed, 15 were selected, which included 111 individual data, 21 mean values related to human adult hemoglobin (HbA) and 57 mean values for fetal hemoglobin (HbF) at known temperature and pH. The median M value at physiological conditions was 218 [191–257] (n = 19) for HbA and 175 [158–192] for HbF. There was a negative correlation between temperature and M value (p < 0.001), but no correlation between M and pH for HbA (p = 0.33), conversely to HbF (p = 0.044). Data were insufficient to perform a meta-analysis on the dependence between M and 2,3-DPG concentration, atmospheric pressure, pregnancy, methemoglobin, and sickle Hb. Our analysis confirmed that the M value in humans at physiological conditions is 218 for HbA and 175 for HbF. Temperature influences M, but further studies are required to clarify pH influence.
- Published
- 2020
199. Prior Exposure to Angiotensin II Receptor Blockers in Patients With Septic Shock to Individualize Mean Arterial Pressure Target? A Post Hoc Analysis of the Sepsis and Mean Arterial Pressure (SEPSISPAM) Trial*
- Author
-
Demiselle, Julien, primary, Seegers, Valérie, additional, Lemerle, Marie, additional, Meziani, Ferhat, additional, Grelon, Fabien, additional, Megarbane, Bruno, additional, Anguel, Nadia, additional, Mira, Jean-Paul, additional, Dequin, Pierre-François, additional, Gergaud, Soizic, additional, Weiss, Nicolas, additional, Legay, François, additional, Le Tulzo, Yves, additional, Conrad, Marie, additional, Robert, René, additional, Gonzalez, Frédéric, additional, Guitton, Christophe, additional, Tamion, Fabienne, additional, Tonnelier, Jean-Marie, additional, Bédos, Jean-Pierre, additional, Van Der Linden, Thierry, additional, Vieillard-Baron, Antoine, additional, Mariotte, Eric, additional, Pradel, Gaël, additional, Lesieur, Olivier, additional, Ricard, Jean-Damien, additional, Hervé, Fabien, additional, du Cheyron, Damien, additional, Guerin, Claude, additional, Teboul, Jean-Louis, additional, Helms, Julie, additional, Radermacher, Peter, additional, and Asfar, Pierre, additional
- Published
- 2021
- Full Text
- View/download PDF
200. Clinical Toxicology review metrics and expert reviewers, 2020
- Author
-
Seifert, Steven A., primary, Buckley, Nicholas, additional, Chan, Betty, additional, Chan, Thomas Y. K., additional, Cumpston, Kirk, additional, Kirschner, Ronald I., additional, Megarbane, Bruno, additional, Mullins, Michael, additional, Seger, Donna, additional, Thomas, Simon, additional, Vale, J. Allister, additional, and Wilks, Martin F., additional
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.