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Mooren's ulcer is a painless and idiopathic ulcer of the peripheral cornea related to autoimmunity against a corneal stromal antigen, calgranulin C. Corneal involvement is isolated. There are no specific histopathological features to differentiate Mooren's ulcer from pseudo-Mooren's, the latter being part of a systemic disease. Mooren ulcer is a diagnosis of elimination based on a complete etiological check-up. However, histopathological examination, when performed, could provide additional data to support the diagnosis. We report the case of a 78-year-old female patient who presented with Mooren's ulcer. The patient had complained of red eye and photophobia for two weeks. Initial visual acuity was "counting fingers". Clinical examination revealed a perforated perilimbic ulcer with an iris prolapse. Based on the peripheral ulcerative keratitis, with a negative etiological work-up and anatomopathological analysis of the cornea, the diagnosis of Mooren's ulcer was proposed. This rare case illustrates the need for a multidisciplinary approach involving ophthalmologists, pathologists, and internists, to reach a diagnosis and optimize the functional prognosis., (Copyright © 2024. Published by Elsevier Masson SAS.)

Introduction: Recent observations have shown that lengthening the daily eating period may contribute to the onset of chronic diseases. Time-restricted eating (TRE) is a diet that especially limits this daily food window. It could represent a dietary approach that is likely to improve health markers. The aim of this study was to review how time-restricted eating affects human health., Method: Five general databases and six nutrition journals were screened to identify all studies published between January 2014 and September 2020 evaluating the effects of TRE on human populations., Results: Among 494 articles collected, 23 were finally included for analysis. The overall adherence rate to TRE was 80%, with a 20% unintentional reduction in caloric intake. TRE induced an average weight loss of 3% and a loss of fat mass. This fat loss was also observed without any caloric restriction. Interestingly, TRE produced beneficial metabolic effects independently of weight loss, suggesting an intrinsic effect based on the realignment of feeding and the circadian clock., Conclusions: TRE is a simple and well-tolerated diet that generates many beneficial health effects based on chrononutrition principles. More rigorous studies are needed, however, to confirm those effects, to understand their mechanisms and to assess their applicability to human health.