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151. Prescribing Of Chloramphenicol In General Practice

Author: Meade, T. W.
Published: 1967

152. VENTILATION OF SEWERS

Author: DE COURCY MEADE, T.
Published: 1912
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153. Accuracy of Diagnosis on Death Certificates Compared with That in Hospital Records

Author: Alderson, M. R. and Meade, T. W.
Published: 1967

154. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

Author: Whitlock, Gary, Lewington, Sarah, Sherliker, Paul, Clarke, Robert, Emberson, Jonathan, Halsey, Jim, Qizilbash, Nawab, Collins, Rory, Peto, Richard, Lewington, S, MacMahon, S, Peto, R, Aromaa, A, Baigent, C, Carstensen, J, Chen, Z, Clarke, R, Collins, R, Duffy, S, Kromhout, D, Neaton, J, Qizilbash, N, Rodgers, A, Tominaga, S, Toernberg, S, Tunstall-Pedoe, H, Whitlock, G, Chambless, L, De Backer, G, De Bacquer, D, Kornitzer, M, Whincup, P, Wannamethee, SG, Morris, R, Wald, N, Morris, J, Law, M, Knuiman, M, Bartholomew, H, Smith, G Davey, Sweetnam, P, Elwood, P, Yarnell, J, Kronmal, R, Sutherland, S, Keil, J, Jensen, G, Schnohr, P, Hames, C, Tyroler, A, Knekt, P, Reunanen, A, Tuomilehto, J, Jousilahti, P, VArtiainen, E, Puska, P, Kuznetsova, Tatiana, Richart, Tom, Staessen, Jan A, Thijs, Lutgarde, Jorgensen, T, Thomsen, T, Sharp, D, Curb, JD, Iso, H, Sato, S, Kitamura, A, Naito, Y, Benetos, A, Guize, L, Goldbourt, U, Tomita, M, Nishimoto, Y, Murayama, T, Criqui, M, Davis, C, Hart, C, Hole, D, Gillis, C, Jacobs, D, Blackburn, H, Luepker, R, Eberly, L, Cox, C, Levy, D, D'Agostino, R, Silbershatz, H, Tverdal, A, Selmer, R, Meade, T, Garrow, K, Cooper, J, Speizer, F, Stampfer, M, Menotti, A, Spagnolo, A, Tsuji, I, Imai, Y, Ohkubo, T, Hisamichi, S, Haheim, L, Holme, I, Hjermann, I, Leren, P, Ducimetiere, P, Empana, J, Jamrozik, K, Broadhurst, R, Assmann, G, Schulte, H, Bengtsson, C, Bjoerkelund, C, Lissner, L, Sorlie, P, Garcia-Palmieri, M, Barrett-Conner, E, Langer, R, Nakachi, K, Imai, K, Fang, X, Buzina, R, Nissinen, A, Aravanis, C, Dontas, A, Kafatos, A, Adachi, H, Toshima, H, Imaizumi, T, Nedeljkovic, S, Ostojic, M, CHen, Z, Nakayama, T, Yoshiike, N, Yokoyama, T, Date, C, Tanaka, H, Keller, J, Bonaa, K, Arnesen, E, Rimm, E, Gaziano, M, Buring, JE, Hennekens, C, Tornberg, S, Shipley, M, Leon, D, Marmot, M, Emberson, J, Halsey, J, Palmer, A, Parish, S, and Sherliker, P
Subjects: Male, obesity, Nutrition and Disease, Respiratory Tract Diseases, Myocardial Ischemia, individual data, 030204 cardiovascular system & hematology, Overweight, Body Mass Index, 0302 clinical medicine, blood-pressure, Cause of Death, Voeding en Ziekte, Medicine, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, risk, Cause of death, Aged, 80 and over, Hazard ratio, Articles, General Medicine, Middle Aged, 3. Good health, Stroke, Female, medicine.symptom, Adult, medicine.medical_specialty, Waist, abdominal adiposity, united-states, 03 medical and health sciences, vascular mortality, Internal medicine, Humans, korean men, Mortality, Aged, VLAG, business.industry, Anthropometry, medicine.disease, Obesity, Surgery, randomized-trials, coronary-heart-disease, business, Body mass index
Abstract: Summary Background The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective Studies Collaboration aimed to investigate these associations by sharing data from many studies. Methods Collaborative analyses were undertaken of baseline BMI versus mortality in 57 prospective studies with 894 576 participants, mostly in western Europe and North America (61% [n=541 452] male, mean recruitment age 46 [SD 11] years, median recruitment year 1979 [IQR 1975–85], mean BMI 25 [SD 4] kg/m2). The analyses were adjusted for age, sex, smoking status, and study. To limit reverse causality, the first 5 years of follow-up were excluded, leaving 66 552 deaths of known cause during a mean of 8 (SD 6) further years of follow-up (mean age at death 67 [SD 10] years): 30 416 vascular; 2070 diabetic, renal or hepatic; 22 592 neoplastic; 3770 respiratory; 7704 other. Findings In both sexes, mortality was lowest at about 22·5–25 kg/m2. Above this range, positive associations were recorded for several specific causes and inverse associations for none, the absolute excess risks for higher BMI and smoking were roughly additive, and each 5 kg/m2 higher BMI was on average associated with about 30% higher overall mortality (hazard ratio per 5 kg/m2 [HR] 1·29 [95% CI 1·27–1·32]): 40% for vascular mortality (HR 1·41 [1·37–1·45]); 60–120% for diabetic, renal, and hepatic mortality (HRs 2·16 [1·89–2·46], 1·59 [1·27–1·99], and 1·82 [1·59–2·09], respectively); 10% for neoplastic mortality (HR 1·10 [1·06–1·15]); and 20% for respiratory and for all other mortality (HRs 1·20 [1·07–1·34] and 1·20 [1·16–1·25], respectively). Below the range 22·5–25 kg/m2, BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer. These inverse associations were much stronger for smokers than for non-smokers, despite cigarette consumption per smoker varying little with BMI. Interpretation Although other anthropometric measures (eg, waist circumference, waist-to-hip ratio) could well add extra information to BMI, and BMI to them, BMI is in itself a strong predictor of overall mortality both above and below the apparent optimum of about 22·5–25 kg/m2. The progressive excess mortality above this range is due mainly to vascular disease and is probably largely causal. At 30–35 kg/m2, median survival is reduced by 2–4 years; at 40–45 kg/m2, it is reduced by 8–10 years (which is comparable with the effects of smoking). The definite excess mortality below 22·5 kg/m2 is due mainly to smoking-related diseases, and is not fully explained. Funding UK Medical Research Council, British Heart Foundation, Cancer Research UK, EU BIOMED programme, US National Institute on Aging, and Clinical Trial Service Unit (Oxford, UK).
Published: 2009
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155. PARTNER INVOLVEMENT: NEGOTIATING THE PRESENCE OF PARTNERS IN PSYCHOSOCIAL ASSESSMENT AS CONDUCTED BY MIDWIVES AND CHILD AND FAMILY HEALTH NURSES

Author: Rollans, M, Kohlhoff, J, Meade, T, Kemp, L, and Schmied, V
Subjects: Postnatal Care, Adult, Male, Mental Disorders, Developmental & Child Psychology, Puerperal Disorders, Midwifery, Depression, Postpartum, Interviews as Topic, Pregnancy, Family Nursing, Humans, Female, Spouses, Nurses, Pediatric, Anthropology, Cultural
Published: 2016

156. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Author: Schmidt, A.F., Swerdlow, D.I., Holmes, M.V., Patel, R.S., Fairhurst-Hunter, Z., Lyall, D.M., Hartwig, F.P., Horta, B.L., Hypponen, E., Power, C., Moldovan, M., Iperen, E. van, Hovingh, G.K., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Liu, T., Coassin, S., Willeit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J.F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A.G., Onland-Moret, N.C., Schouw, Y.T. van der, Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N.J., Langenberg, C., Scott, R., Luan, J.A., Bobak, M., Malyutina, S.A., Pajak, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Husemoen, L.L.N., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Simonsen, K.S., Cooper, J., Humphries, S.E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D.S., McCarty, C.A., Kirchner, H.L., Larson, E.B., Crosslin, D.R., Andrade, M. de, Roden, D.M., Denny, J.C., Carty, C., Hancock, S., Attia, J., Holliday, E., Donnell, M.O., Yusuf, S., Chong, M., Pare, G., Harst, P. van der, Said, M.A., Eppinga, R.N., Verweij, N., Snieder, H., Christen, T., Mook-Kanamori, D.O., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dorr, M., Lerch, M.M., Volker, U., Volzke, H., Ward, J., Pell, J.P., Smith, D.J., Meade, T., Maitland-van der Zee, A.H., Baranova, E.V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M.L., Grobbee, D.E., Froguel, P., Thuillier, D., Balkau, B., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Ridker, P.M., Chasman, D.I., Reiner, A.P., Lange, L.A., Ritchie, M.D., Asselbergs, F.W., Casas, J.P., Keating, B.J., Preiss, D., Hingorani, A.D., Sattar, N., LifeLines Cohort Study Grp, UCLEB Consortium, Centre for Paediatric Epidemiology and Biostatistics, University College of London [London] (UCL), MRC Centre for Epidemiology of Child Health, UCL Institute of Child Health, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Dept. of Gastroenterology, Hepatology and Endocrinology, Neuroepidemiology of Ageing Research Unit, Imperial College London, Institut des Sciences Moléculaires (ISM), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Université Sciences et Technologies - Bordeaux 1-Université Montesquieu - Bordeaux 4-Institut de Chimie du CNRS (INC), Division of Community Health Sciences, St George's University of London, Department of Social Medicine, University of Bristol [Bristol], Finnish Institute of Occupational Health of Helsinki, Department of Epidemiology and Public Health, Institute of Social and Preventive Medicine, Lausanne university hospital, Computer Science Department, University of Cyprus, Cyprus Institute of Neurology and Genetics, University Medical Center [Utrecht], Department of Genetics, Biology and Biochemistry, University of Turin, Institute for Scientific Interchange Foundation, Center for Cancer Prevention, CPO-Piemonte, Unità di epidemiologia dei tumori, Università degli studi di Torino (UNITO)-HuGeF Foundation, Medical Research Council Epidemiology Unit, University of Cambridge [UK] (CAM), Serono Genetics Institute S.A.[Evry], Serono Genetics Institute, Institute of Internal and Preventive Medicine Sibe rian Branch, Russian Academy of Medical Sciences, Institute of Internal Medicine, Novosibirsk State Medical University, Centre for Environmental Health, National Institute of Public Health [Prague], Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), University of Copenhagen = Københavns Universitet (KU), Research Centre for Prevention and Health (RCPH), Department of Public Health [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Capital Region of Denmark, Rigshospitalet [Copenhagen], Copenhagen University Hospital, BHF Laboratories, Rayne building, Department of Medicine, 5 University Street, The Center for Applied Genomics, Children’s Hospital of Philadelphia (CHOP ), Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania [Philadelphia]-University of Pennsylvania [Philadelphia]-Children’s Hospital of Philadelphia (CHOP ), Population Health Research Institute, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen [Groningen], Augusta University - Medical College of Georgia, University System of Georgia (USG)-University System of Georgia (USG), Limnology, Ecology, Uppsala Universitet [Uppsala], Metacohorts Consortium, Erasmus University Medical Center [Rotterdam] (Erasmus MC), King‘s College London, Interfaculty Institute for Genetics and Functional Genomics, Universität Greifswald - University of Greifswald, Institute for Community Medicine, Department of Oncology and Metabolism [Sheffield, UK], The University of Sheffield [Sheffield, U.K.], European Associated Laboratory [Sheffield, UK] (Sarcoma Research Unit), Robertson Centre for Biostatistics, University of Glasgow, Faculty of Medicine, University of Glasgow, Julius Center for Health Sciences and Primary Care, Génétique des maladies multifactorielles (GMM), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), INSERM UMRS 1178, Institut de recherche en biothérapie (IRB), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Physics, Indian Institute of Technology Kanpur (IIT Kanpur), Department of Pathological Biochemistry, Royal Infirmary, Wareham, Nicholas [0000-0003-1422-2993], Langenberg, Claudia [0000-0002-5017-7344], Luan, Jian'an [0000-0003-3137-6337], and Apollo - University of Cambridge Repository
Subjects: Blood Glucose, Cohort Studies, Diabetes Mellitus, Type 2, Case-Control Studies, [SDV]Life Sciences [q-bio], Genetic Variation, Humans, Genetic Predisposition to Disease, Cholesterol, LDL, Mendelian Randomization Analysis, Proprotein Convertase 9, Randomized Controlled Trials as Topic
Abstract: BACKGROUND:Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.METHODS:In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic variants with LDL cholesterol, fasting blood glucose, HbA1c, fasting insulin, bodyweight, waist-to-hip ratio, BMI, and risk of type 2 diabetes, using a standardised analysis plan, meta-analyses, and weighted gene-centric scores.FINDINGS:Data were available for more than 550 000 individuals and 51 623 cases of type 2 diabetes. Combined analyses of four independent PCSK9 variants (rs11583680, rs11591147, rs2479409, and rs11206510) scaled to 1 mmol/L lower LDL cholesterol showed associations with increased fasting glucose (0·09 mmol/L, 95% CI 0·02 to 0·15), bodyweight (1·03 kg, 0·24 to 1·82), waist-to-hip ratio (0·006, 0·003 to 0·010), and an odds ratio for type diabetes of 1·29 (1·11 to 1·50). Based on the collected data, we did not identify associations with HbA1c (0·03%, -0·01 to 0·08), fasting insulin (0·00%, -0·06 to 0·07), and BMI (0·11 kg/m2, -0·09 to 0·30).INTERPRETATION:PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefits of PCSK9 inhibitor treatment, as was previously done for statins.FUNDING:British Heart Foundation, and University College London Hospitals NHS Foundation Trust (UCLH) National Institute for Health Research (NIHR) Biomedical Research Centre.
Published: 2016
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157. Pain severity predicts depressive symptoms over and above individual illnesses and multimorbidity in older adults

Author: Sharpe, L., McDonald, S., Correia, H.M., Raue, P.J., Meade, T., Nicholas, M.K., Areán, P.A., Sharpe, L., McDonald, S., Correia, H.M., Raue, P.J., Meade, T., Nicholas, M.K., and Areán, P.A.
Abstract: Background: Multi-morbidity in older adults is commonly associated with depressed mood. Similarly, subjective reports of pain are also associated with both physical illness and increased depressive symptoms. However, whether pain independently contributes to the experience of depression in older people with multi-morbidity has not been studied. Methods: In this study, participants were 1281 consecutive older adults presenting to one of 19 primary care services in Australia (recruitment rate = 75%). Participants were asked to indicate the presence of a number of common chronic illnesses, to rate their current pain severity and to complete the Geriatric Depression Scale. Results: Results confirmed that the number of medical illnesses reported was strongly associated with depressive symptoms. Twenty-six percent of participants with multi-morbidity scored in the clinical range for depressive symptoms in comparison to 15% of participants with no illnesses or a single illness. In regression analyses, the presence of chronic pain (t = 5.969, p < 0.0005), diabetes (t = 4.309, p < 0.0005), respiratory (t = 3.720, p < 0.0005) or neurological illness (t = 2.701, p = 0.007) were all independent contributors to depressive symptoms. Even when controlling for each individual illness, and the overall number of illnesses (t = 2.207, p = 0.028), pain severity remained an independent predictor of depressed mood (F change = 28.866, p < 0.0005, t = 5.373, p < 0.0005). Conclusions: Physicians should consider screening for mood problems amongst those with multi-morbidity, particularly those who experience pain.
Published: 2017

158. Pain severity predicts depressive symptoms over and above individual illnesses and multimorbidity in older adults.

Author: Sharpe, L, McDonald, S, Correia, H, Raue, PJ, Meade, T, Nicholas, M, Arean, P, Sharpe, L, McDonald, S, Correia, H, Raue, PJ, Meade, T, Nicholas, M, and Arean, P
Abstract: BACKGROUND: Multi-morbidity in older adults is commonly associated with depressed mood. Similarly, subjective reports of pain are also associated with both physical illness and increased depressive symptoms. However, whether pain independently contributes to the experience of depression in older people with multi-morbidity has not been studied. METHODS: In this study, participants were 1281 consecutive older adults presenting to one of 19 primary care services in Australia (recruitment rate = 75%). Participants were asked to indicate the presence of a number of common chronic illnesses, to rate their current pain severity and to complete the Geriatric Depression Scale. RESULTS: Results confirmed that the number of medical illnesses reported was strongly associated with depressive symptoms. Twenty-six percent of participants with multi-morbidity scored in the clinical range for depressive symptoms in comparison to 15% of participants with no illnesses or a single illness. In regression analyses, the presence of chronic pain (t = 5.969, p < 0.0005), diabetes (t = 4.309, p < 0.0005), respiratory (t = 3.720, p < 0.0005) or neurological illness (t = 2.701, p = 0.007) were all independent contributors to depressive symptoms. Even when controlling for each individual illness, and the overall number of illnesses (t = 2.207, p = 0.028), pain severity remained an independent predictor of depressed mood (F change = 28.866, p < 0.0005, t = 5.373, p < 0.0005). CONCLUSIONS: Physicians should consider screening for mood problems amongst those with multi-morbidity, particularly those who experience pain.
Published: 2017

159. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Author: Schmidt, AF, Swerdlow, DI, Holmes, MV, Patel, RS, Fairhurst-Hunter, Z, Lyall, DM, Hartwig, FP, Horta, BL, Hypponen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, GK, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-Shlomo, Y, McLachlan, S, Price, JF, Kivimaki, M, Welch, C, Sanchez-Galvez, A, Marques-Vidal, P, Nicolaides, A, Panayiotou, AG, Onland-Moret, NC, van der Schouw, YT, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, NJ, Langenberg, C, Scott, R, Luan, JA, Bobak, M, Malyutina, SA, Pajak, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, LLN, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, KS, Cooper, J, Humphries, SE, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, DS, McCarty, CA, Kirchner, HL, Larson, EB, Crosslin, DR, de Andrade, M, Roden, DM, Denny, JC, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, MO, Yusuf, S, Chong, M, Pare, G, van der Harst, P, Said, MA, Eppinga, RN, Verweij, N, Snieder, H, Christen, T, Mook-Kanamori, DO, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, Raha, Franco Duran, OH, Hofman, Bert, Uitterlinden, André, Dehghan, Abbas, Teumer, A, Baumeister, S, Dorr, M, Lerch, MM, Volker, U, Volzke, H, Ward, J, Pell, JP, Smith, Derek, Meade, T, Zee, AH, Baranova, EV, Young, R, Ford, I, Campbell, A (Archie), Padmanabhan, S, Bots, ML, Grobbee, DE, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, PM, Chasman, DI, Reiner, AP, Lange, LA, Ritchie, MD, Asselbergs, FW, Casas, JP, Keating, BJ, Preiss, D, Hingorani, AD, Sattar, N, Schmidt, AF, Swerdlow, DI, Holmes, MV, Patel, RS, Fairhurst-Hunter, Z, Lyall, DM, Hartwig, FP, Horta, BL, Hypponen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, GK, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-Shlomo, Y, McLachlan, S, Price, JF, Kivimaki, M, Welch, C, Sanchez-Galvez, A, Marques-Vidal, P, Nicolaides, A, Panayiotou, AG, Onland-Moret, NC, van der Schouw, YT, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, NJ, Langenberg, C, Scott, R, Luan, JA, Bobak, M, Malyutina, SA, Pajak, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, LLN, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, KS, Cooper, J, Humphries, SE, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, DS, McCarty, CA, Kirchner, HL, Larson, EB, Crosslin, DR, de Andrade, M, Roden, DM, Denny, JC, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, MO, Yusuf, S, Chong, M, Pare, G, van der Harst, P, Said, MA, Eppinga, RN, Verweij, N, Snieder, H, Christen, T, Mook-Kanamori, DO, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, Raha, Franco Duran, OH, Hofman, Bert, Uitterlinden, André, Dehghan, Abbas, Teumer, A, Baumeister, S, Dorr, M, Lerch, MM, Volker, U, Volzke, H, Ward, J, Pell, JP, Smith, Derek, Meade, T, Zee, AH, Baranova, EV, Young, R, Ford, I, Campbell, A (Archie), Padmanabhan, S, Bots, ML, Grobbee, DE, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, PM, Chasman, DI, Reiner, AP, Lange, LA, Ritchie, MD, Asselbergs, FW, Casas, JP, Keating, BJ, Preiss, D, Hingorani, AD, and Sattar, N
Published: 2017

160. Associations Between Fibrinolytic Activity and Other Variables in an Industrial Population

Author: W. R. S. North Mrc-Dhss Epidemiology and Medical Care Unit, Meade, T. W., Chakrabarti, R., Manning, George W., editor, and Haust, M. Daria, editor
Published: 1977
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161. Determination of Who May Derive Most Benefit From Aspirin in Primary Prevention: Subgroup Results From a Randomised Controlled Trial

Author: Meade, T.
Subjects: Aspirin -- Usage, Coronary heart disease -- Prevention
Published: 2000

162. What Moves You? Testing Personality Characteristics for Transportability in Entertainment

Author: Meade T
Subjects: Power (social and political), Entertainment, Aesthetics, media_common.quotation_subject, Photojournalism, Personality, Narrative, Political communication, Sociology, Plot (narrative), Social science, News media, media_common
Abstract: Have you ever seen an emotionally moving film? Many films and narratives have the power to transport the viewer to a different world with an immersive story. The viewer becomes so involved in the plot that they feel as if they may be experiencing the highs and lows with the main characters. Why was that film moving? Green and Brock identified the concept of Transportation in narrative. Transportation leads the viewer to â suspend disbelief, âbe entertained, and even persuaded. Why were you moved, but others were not? Green and Brockâs research studied the effects of various plot devices and narrative voices to determine how a viewer is transported into the story.
Published: 2015
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163. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Author: Holmes, MV, Dale, CE, Zuccolo, L, Silverwood, RJ, Guo, Y, Ye, Z, Prieto-Merino, D, Dehghan, Abbas, Trompet, S, Wong, A, Cavadino, A, Drogan, D, Padmanabhan, S, Li, Shan, Yesupriya, A, Leusink, M, Sundstrom, J, Hubacek, JA, Pikhart, H, Swerdlow, DI, Panayiotou, AG, Borinskaya, SA, Finan, C, Shah, S, Kuchenbaecker, KB, Shah, T, Engmann, J, Folkersen, L, Eriksson, P, Ricceri, F, Melander, O, Sacerdote, C, Gamble, DM, Rayaprolu, S, Ross, OA, McLachlan, S, Vikhireva, O, Sluijs, Iris, Scott, RA, Adamkova, V, Flicker, L, van Bockxmeer, FM, Power, C, Marques-Vidal, P, Meade, T, Marmot, MG, Ferro, JM, Paulos-Pinheiro, S, Humphries, SE, Talmud, PJ, Leach, IM, Verweij, N (Niek), Linneberg, A, Skaaby, T, Doevendans, PA, Cramer, MJ, van der Harst, P, Klungel, OH, Dowling, NF, Dominiczak, AF, Kumari, M, Nicolaides, AN, Weikert, C, Boeing, H, Ebrahim, S, Gaunt, TR, Price, JF, Lannfelt, L, Peasey, A, Kubinova, R, Pajak, A, Malyutina, S, Voevoda, MI, Tamosiunas, A, Zee, AH, Norman, PE, Hankey, GJ, Bergmann, MM, Hofman, Bert, Franco Duran, OH, Cooper, J, Palmen, J, Spiering, W, Jong, PA, Kuh, D, Hardy, R, Uitterlinden, André, Ikram, Arfan, Ford, I, Hyppoenen, E, Almeida, OP, Wareham, NJ, Khaw, KT, Hamsten, A, Husemoen, LLN, Tjonneland, A, Tolstrup, JS, Rimm, E, Beulens, JWJ, Verschuren, WMM, Onland-Moret, NC, Hofker, MH, Wannamethee, SG, Whincup, PH, Morris, R, Vicente, AM, Watkins, H, Farrall, M, Jukema, JW, Meschia, J, Cupples, LA, Sharp, SJ, Fornage, M, Kooperberg, C, Lacroix, AZ, Dai, JY, Lanktree, MB, Siscovick, DS, Jorgenson, E, Spring, B, Coresh, J, Li, YR, Buxbaum, SG, Schreiner, PJ, Ellison, RC, Tsai, MY, Patel, SR, Redline, S, Johnson, AD, Hoogeveen, RC, Rotter, JI, Boerwinkle, E, de Bakker, PIW, Kivimaki, M, Asselbergs, FW, Sattar, N, Lawlor, DA, Whittaker, J, Smith, GD, Mukamal, K, Psaty, BM, Wilson, JG, Lange, LA, Hamidovic, A, Hingorani, AD, Nordestgaard, BG, Bobak, M, Leon, DA, Langenberg, C, Palmer, TM, Reiner, AP, Keating, BJ, Dudbridge, F, Casas, JP, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology, Clinical Genetics, Epidemiology, Erasmus MC other, Internal Medicine, and Radiology & Nuclear Medicine
Subjects: Medicine(all), Alcohol dehydrogenase 1B gene, SDG 3 - Good Health and Well-being, Alcohol consumption, Alcohol abstinence, Clinical Medicine, Medical and Health Sciences
Abstract: Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures: Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption. Results: Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m2). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)). Conclusions: Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.
Published: 2014

164. The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

Author: Danesh, J, Erqou, S, Walker, M, Thompson, Sg, Tipping, R, Ford, C, Pressel, S, Walldius, G, Jungner, I, Folsom, Ar, Chambless, Le, Knuiman, M, Whincup, Ph, Wannamethee, Sg, Morris, Rw, Willeit, J, Kiechl, S, Santer, P, Mayr, A, Wald, N, Ebrahim, S, Lawlor, Da, Yarnell, Jw, Gallacher, J, Casiglia, Edoardo, Tikhonoff, Valerie, Nietert, Pj, Sutherland, Se, Bachman, Dl, Keil, Je, Cushman, M, Psaty, Bm, Tracy, Rp, Tybjaerg Hansen, A, Nordestgaard, Bg, Frikke Schmidt, R, Giampaoli, S, Palmieri, L, Panico, S, Vanuzzo, D, Pilotto, L, Simons, L, Mccallum, J, Friedlander, Y, Fowkes, Fg, Lee, Aj, Smith, Fb, Taylor, J, Guralnik, J, Phillips, C, Wallace, R, Blazer, D, Khaw, Kt, Jansson, Jh, Donfrancesco, C, Salomaa, V, Harald, K, Jousilahti, P, Vartiainen, E, Woodward, M, D'Agostino, Rb, Wolf, Pa, Vasan, Rs, Pencina, Mj, Bladbjerg, Em, Jorgensen, T, Moller, L, Jespersen, J, Dankner, R, Chetrit, A, Lubin, F, Rosengren, A, Wilhelmsen, L, Lappas, G, Eriksson, H, Bjorkelund, C, Cremer, P, Nagel, D, Tilvis, R, Strandberg, T, Rodriguez, B, Bouter, Lm, Heine, Rj, Dekker, Jm, Nijpels, G, Stehouwer, Cd, Rimm, E, Pai, J, Sato, S, Iso, H, Kitamura, A, Noda, H, Goldbourt, U, Salonen, Jt, Nyyssönen, K, Tuomainen, Tp, Deeg, D, Poppelaars, Jl, Meade, T, Cooper, J, Hedblad, B, Berglund, G, Engstrom, G, Döring, A, Koenig, W, Meisinger, C, Mraz, W, Kuller, L, Selmer, R, Tverdal, A, Nystad, W, Gillum, R, Mussolino, M, Hankinson, S, Manson, J, De Stavola, B, Knottenbelt, C, Cooper, Ja, Bauer, Ka, Rosenberg, Rd, Naito, Y, Holme, I, Nakagawa, H, Miura, H, Ducimetiere, P, Jouven, X, Crespo, C, Garcia Palmieri, M, Amouyel, P, Arveiler, D, Evans, A, Ferrieres, J, Schulte, H, Assmann, G, Shepherd, J, Packard, C, Sattar, N, Cantin, B, Lamarche, B, Després, Jp, Dagenais, Gr, Barrett Connor, E, Wingard, D, Bettencourt, R, Gudnason, V, Aspelund, T, Sigurdsson, G, Thorsson, B, Trevisan, M, Witteman, J, Kardys, I, Breteler, M, Hofman, A, Tunstall Pedoe, H, Tavendale, R, Lowe, Gd, Ben Shlomo, Y, Howard, Bv, Zhang, Y, Best, L, Umans, J, Onat, A, Meade, Tw, Njolstad, I, Mathiesen, E, Lochen, Ml, Wilsgaard, T, Gaziano, Jm, Stampfer, M, Ridker, P, Ulmer, H, Diem, G, Concin, H, Rodeghiero, F, Tosetto, A, Brunner, E, Shipley, M, Buring, J, Cobbe, Sm, Ford, I, Robertson, M, He, Y, Ibanez, Am, Feskens, Ej, Kromhout, D, Collins, R, Di Angelantonio, E, Kaptoge, S, Lewington, S, Orfei, L, Pennells, L, Perry, P, Ray, K, Sarwar, N, Scherman, M, Thompson, A, Watson, S, Wensley, F, White, Ir, Wood, Am, Emerging Risk Factors Collaboration, Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: CARIM School for Cardiovascular Diseases, Movement Behavior, Executive board Vrije Universiteit, Clinical Child and Family Studies, Sociology and Social Gerontology, Earth and Climate, Environmental Policy Analysis, Developmental Genetics, Danesh, J, Erqou, S, Walker, M, Thompson, Sg, Tipping, R, Ford, C, Pressel, S, Walldius, G, Jungner, I, Folsom, Ar, Chambless, Le, Knuiman, M, Whincup, Ph, Wannamethee, Sg, Morris, Rw, Willeit, J, Kiechl, S, Santer, P, Mayr, A, Wald, N, Ebrahim, S, Lawlor, Da, Yarnell, Jw, Gallacher, J, Casiglia, E, Tikhonoff, V, Nietert, Pj, Sutherland, Se, Bachman, Dl, Keil, Je, Cushman, M, Psaty, Bm, Tracy, Rp, Tybjaerg Hansen, A, Nordestgaard, Bg, Frikke Schmidt, R, Giampaoli, S, Palmieri, L, Panico, Salvatore, Vanuzzo, D, Pilotto, L, Simons, L, Mccallum, J, Friedlander, Y, Fowkes, Fg, Lee, Aj, Smith, Fb, Taylor, J, Guralnik, J, Phillips, C, Wallace, R, Blazer, D, Khaw, Kt, Jansson, Jh, Donfrancesco, C, Salomaa, V, Harald, K, Jousilahti, P, Vartiainen, E, Woodward, M, D'Agostino, Rb, Wolf, Pa, Vasan, R, Pencina, Mj, Bladbjerg, Em, Jorgensen, T, Moller, L, Jespersen, J, Dankner, R, Chetrit, A, Lubin, F, Rosengren, A, Wilhelmsen, L, Lappas, G, Eriksson, H, Bjorkelund, C, Cremer, P, Nagel, D, Tilvis, R, Strandberg, T, Rodriguez, B, Bouter, Lm, Heine, Rj, Dekker, Jm, Nijpels, G, Stehouwer, Cd, Rimm, E, Pai, J, Sato, S, Iso, H, Kitamura, A, Noda, H, Goldbourt, U, Salonen, Jt, Nyyssönen, K, Tuomainen, Tp, Deeg, D, Poppelaars, Jl, Meade, T, Cooper, J, Hedblad, B, Berglund, G, Engstrom, G, Döring, A, Koenig, W, Meisinger, C, Mraz, W, Kuller, L, Selmer, R, Tverdal, A, Nystad, W, Gillum, R, Mussolino, M, Hankinson, S, Manson, J, De Stavola, B, Knottenbelt, C, Cooper, Ja, Bauer, Ka, Rosenberg, Rd, Naito, Y, Holme, I, Nakagawa, H, Miura, H, Ducimetiere, P, Jouven, X, Crespo, C, Garcia Palmieri, M, Amouyel, P, Arveiler, D, Evans, A, Ferrieres, J, Schulte, H, Assmann, G, Shepherd, J, Packard, C, Sattar, N, Cantin, B, Lamarche, B, Després, Jp, Dagenais, Gr, Barrett Connor, E, Wingard, D, Bettencourt, R, Gudnason, V, Aspelund, T, Sigurdsson, G, Thorsson, B, Trevisan, M, Witteman, J, Kardys, I, Breteler, M, Hofman, A, Tunstall Pedoe, H, Tavendale, R, Lowe, Gd, Ben Shlomo, Y, Howard, Bv, Zhang, Y, Best, L, Umans, J, Onat, A, Meade, Tw, Njolstad, I, Mathiesen, E, Lochen, Ml, Wilsgaard, T, Gaziano, Jm, Stampfer, M, Ridker, P, Ulmer, H, Diem, G, Concin, H, Rodeghiero, F, Tosetto, A, Brunner, E, Shipley, M, Buring, J, Cobbe, Sm, Ford, I, Robertson, M, He, Y, Ibanez, Am, Feskens, Ej, Kromhout, D, Collins, R, Di Angelantonio, E, Kaptoge, S, Lewington, S, Orfei, L, Pennells, L, Perry, P, Ray, K, Sarwar, N, Scherman, M, Thompson, A, Watson, S, Wensley, F, White, Ir, and Wood, A. M.
Subjects: Databases, Factual, Nutrition and Disease, Epidemiology, Inflammatory markers, middle-aged men, Disease, Leukocyte Count, c-reactive protein, Risk Factors, Voeding en Ziekte, adult-treatment-panel, Prospective Studies, Myocardial infarction, Prospective cohort study, education.field_of_study, biology, plasma-fibrinogen, Asia, Eastern, Confounding, density-lipoprotein cholesterol, Cardiovascular disease, Lipids, myocardial-infarction, Coronary heart disease, Cardiovascular Diseases, Meta-analysis, Lipoproteins, HDL, high blood cholesterol, medicine.medical_specialty, low-dose aspirin, Population, 10-year follow-up, SDG 3 - Good Health and Well-being, Albumins, medicine, Humans, education, Triglycerides, VLAG, Inflammation, Estimation, business.industry, C-reactive protein, medicine.disease, Surgery, Emergency medicine, biology.protein, business, coronary-heart-disease, Biomarkers
Abstract: Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circumstances and to correct for within-person variability. The Emerging Risk Factors Collaboration has established a central database on over 1.1 million participants from 104 prospective population-based studies, in which subsets have information on lipid and inflammatory markers, other characteristics, as well as major cardiovascular morbidity and cause-specific mortality. Information on repeat measurements on relevant characteristics has been collected in approximately 340,000 participants to enable estimation of and correction for within-person variability. Re-analysis of individual data will yield up to approximately 69,000 incident fatal or nonfatal first ever major cardiovascular outcomes recorded during about 11.7 million person years at risk. The primary analyses will involve age-specific regression models in people without known baseline cardiovascular disease in relation to fatal or nonfatal first ever coronary heart disease outcomes. This initiative will characterize more precisely and in greater detail than has previously been possible the shape and strength of the age-and sex-specific associations of several lipid and inflammatory markers with incident coronary heart disease outcomes (and, secondarily,with other incident cardiovascular outcomes) under a wide range of circumstances. It will, therefore, help to determine to what extent such associations are independent from possible confounding factors and to what extent such markers (separately and in combination) provide incremental predictive value.
Published: 2007
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165. PCSK9 genetic variants and risk of type 2 diabetes: A mendelian randomisation study

Author: Schmidt, A.F. (Amand F.), Swerdlow, D.I. (Daniel), Holmes, M.V. (Michael), Patel, R.S. (Riyaz), Fairhurst-Hunter, Z. (Zammy), Lyall, D.M. (Donald M.), Hartwig, F.P. (Fernando Pires), Horta, B.L. (Bernardo Lessa), Hypponen, E. (Elina), Power, C. (Christopher), Moldovan, M. (Max), Iperen, E.P.A. (Erik) van, Hovingh, G.K. (Kees), Demuth, I. (Ilja), Norman, K. (Kristina), Steinhagen-Thiessen, E. (Elisabeth), Demuth, J. (Juri), Bertram, L. (Lars), Liu, T. (Tian), Coassin, S. (Stefan), Willeit, J. (Johann), Kiechl, S. (Stefan), Willeit, K. (Karin), Mason, D. (Dan), Wright, J. (Juliet), Morris, R.W. (Richard), Wanamethee, G. (Goya), Whincup, P.H. (Peter), Ben-Shlomo, Y., McLachlan, S. (Stela), Price, J.F. (Jackie F.), Kivimaki, M. (Mika), Welch, C. (Catherine), Sanchez-Galvez, A. (Adelaida), Marques-Vidal, P. (Pedro), Nicolaides, A.N. (Andrew), Panayiotou, A.G. (Andrie), Onland-Moret, N.C. (N Charlotte), Schouw, Y.T. (Yvonne) van der, Matullo, G., Fiorito, G. (Giovanni), Guarrera, S. (Simonetta), Sacerdote, C. (Carlotta), Wareham, N.J. (Nick), Langenberg, C. (Claudia), Scott, R. (Robert), Luan, J. (Jian'an), Bobak, M. (Martin), Malyutina, S., Pajak, A. (Andrzej), Kubinova, R., Tamosiunas, A. (Abdonas), Pikhart, H. (Hynek), Husemoen, L.L.N. (Lise Lotte), Grarup, N. (Niels), Pedersen, O. (Oluf), Hansen, T. (T.), Linneberg, A. (Allan), Simonsen, K.S. (Kenneth Starup), Cooper, J. (Jim), Humphries, S.E. (Steve), Brilliant, M.H. (Murray H.), Kitchner, T.E. (Terrie E.), Hakonarson, H. (Hakon), Carrell, D.S. (David), McCarty, C.A. (Catherine A.), Kirchner, H.L. (H Lester), Larson, E.B. (Eric B.), Crosslin, D.R. (David), de Andrade, M. (Mariza), Roden, D.M. (Dan M.), Denny, J.C. (Joshua C.), Carty, C. (Cara), Hancock, S. (Stephen), Attia, J. (John), Holliday, E.G. (Elizabeth), Donnell, M.O.'. (Martin O'), Yusuf, S. (Salim), Chong, M. (Michael), Pare, G. (Guillame), Harst, P. (Pim) van der, Said, M.A. (M Abdullah), Eppinga, R.N. (Ruben N.), Verweij, N. (Niek), Snieder, H. (Harold), Christen, T. (Tim), Mook-Kanamori, D.O. (Dennis), Gustafsson, S. (Stefan), Kao, W.H.L. (Wen), Ingelsson, E. (Erik), Pazoki, R. (Raha), Franco, O.H. (Oscar), Hofman, A. (Albert), Uitterlinden, A.G. (André), Dehghan, A. (Abbas), Teumer, A. (Alexander), Baumeister, S.E. (Sebastian), Dörr, M. (Marcus), Lerch, M.M. (Markus M.), Völker, U. (Uwe), Völzke, H. (Henry), Ward, J. (Joey), Pell, J.P. (Jill P.), Smith, D.J. (Daniel J.), Meade, T. (Tom), Maitland-van der Zee, A-H. (Anke-Hilse), Baranova, E.V. (Ekaterina V.), Young, R. (Robin), Ford, I. (Ian), Campbell, A. (Archie), Padmanabhan, S. (Sandosh), Bots, M.L. (Michiel), Grobbee, D.E. (Diederick E.), Froguel, P. (Philippe), Thuillier, D. (Dorothee), Balkau, B. (Beverley), Bonnefond, A. (Amélie), Cariou, B. (Bertrand), Smart, M. (Melissa), Bao, Y. (Yanchun), Kumari, M. (Meena), Mahajan, A. (Anubha), Ridker, P.M. (Paul), Chasman, D.I. (Daniel I.), Reiner, A. (Alexander), Lange, L.A. (Leslie), Ritchie, M.D. (Marylyn D.), Asselbergs, F.W. (Folkert), Casas, J.P. (Juan), Keating, J. (John), Preiss, D. (David), Hingorani, A. (Aroon), Sattar, N. (Naveed), Schmidt, A.F. (Amand F.), Swerdlow, D.I. (Daniel), Holmes, M.V. (Michael), Patel, R.S. (Riyaz), Fairhurst-Hunter, Z. (Zammy), Lyall, D.M. (Donald M.), Hartwig, F.P. (Fernando Pires), Horta, B.L. (Bernardo Lessa), Hypponen, E. (Elina), Power, C. (Christopher), Moldovan, M. (Max), Iperen, E.P.A. (Erik) van, Hovingh, G.K. (Kees), Demuth, I. (Ilja), Norman, K. (Kristina), Steinhagen-Thiessen, E. (Elisabeth), Demuth, J. (Juri), Bertram, L. (Lars), Liu, T. (Tian), Coassin, S. (Stefan), Willeit, J. (Johann), Kiechl, S. (Stefan), Willeit, K. (Karin), Mason, D. (Dan), Wright, J. (Juliet), Morris, R.W. (Richard), Wanamethee, G. (Goya), Whincup, P.H. (Peter), Ben-Shlomo, Y., McLachlan, S. (Stela), Price, J.F. (Jackie F.), Kivimaki, M. (Mika), Welch, C. (Catherine), Sanchez-Galvez, A. (Adelaida), Marques-Vidal, P. (Pedro), Nicolaides, A.N. (Andrew), Panayiotou, A.G. (Andrie), Onland-Moret, N.C. (N Charlotte), Schouw, Y.T. (Yvonne) van der, Matullo, G., Fiorito, G. (Giovanni), Guarrera, S. (Simonetta), Sacerdote, C. (Carlotta), Wareham, N.J. (Nick), Langenberg, C. (Claudia), Scott, R. (Robert), Luan, J. (Jian'an), Bobak, M. (Martin), Malyutina, S., Pajak, A. (Andrzej), Kubinova, R., Tamosiunas, A. (Abdonas), Pikhart, H. (Hynek), Husemoen, L.L.N. (Lise Lotte), Grarup, N. (Niels), Pedersen, O. (Oluf), Hansen, T. (T.), Linneberg, A. (Allan), Simonsen, K.S. (Kenneth Starup), Cooper, J. (Jim), Humphries, S.E. (Steve), Brilliant, M.H. (Murray H.), Kitchner, T.E. (Terrie E.), Hakonarson, H. (Hakon), Carrell, D.S. (David), McCarty, C.A. (Catherine A.), Kirchner, H.L. (H Lester), Larson, E.B. (Eric B.), Crosslin, D.R. (David), de Andrade, M. (Mariza), Roden, D.M. (Dan M.), Denny, J.C. (Joshua C.), Carty, C. (Cara), Hancock, S. (Stephen), Attia, J. (John), Holliday, E.G. (Elizabeth), Donnell, M.O.'. (Martin O'), Yusuf, S. (Salim), Chong, M. (Michael), Pare, G. (Guillame), Harst, P. (Pim) van der, Said, M.A. (M Abdullah), Eppinga, R.N. (Ruben N.), Verweij, N. (Niek), Snieder, H. (Harold), Christen, T. (Tim), Mook-Kanamori, D.O. (Dennis), Gustafsson, S. (Stefan), Kao, W.H.L. (Wen), Ingelsson, E. (Erik), Pazoki, R. (Raha), Franco, O.H. (Oscar), Hofman, A. (Albert), Uitterlinden, A.G. (André), Dehghan, A. (Abbas), Teumer, A. (Alexander), Baumeister, S.E. (Sebastian), Dörr, M. (Marcus), Lerch, M.M. (Markus M.), Völker, U. (Uwe), Völzke, H. (Henry), Ward, J. (Joey), Pell, J.P. (Jill P.), Smith, D.J. (Daniel J.), Meade, T. (Tom), Maitland-van der Zee, A-H. (Anke-Hilse), Baranova, E.V. (Ekaterina V.), Young, R. (Robin), Ford, I. (Ian), Campbell, A. (Archie), Padmanabhan, S. (Sandosh), Bots, M.L. (Michiel), Grobbee, D.E. (Diederick E.), Froguel, P. (Philippe), Thuillier, D. (Dorothee), Balkau, B. (Beverley), Bonnefond, A. (Amélie), Cariou, B. (Bertrand), Smart, M. (Melissa), Bao, Y. (Yanchun), Kumari, M. (Meena), Mahajan, A. (Anubha), Ridker, P.M. (Paul), Chasman, D.I. (Daniel I.), Reiner, A. (Alexander), Lange, L.A. (Leslie), Ritchie, M.D. (Marylyn D.), Asselbergs, F.W. (Folkert), Casas, J.P. (Juan), Keating, J. (John), Preiss, D. (David), Hingorani, A. (Aroon), and Sattar, N. (Naveed)
Abstract: Background: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering . PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk. Methods: In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic variants with LDL cholesterol, fasting blood glucose, HbA1c, fasting insulin, bodyweight, waist-to-hip ratio, BMI, and risk of type 2 diabetes, using a standardised analysis plan, meta-analyses, and weighted gene-centric scores. Findings: Data were available for more than 550 000 individuals and 51 623 cases of type 2 diabetes. Combined analyses of four independent PCSK9 variants (rs11583680, rs11591147, rs2479409, and rs11206510) scaled to 1 mmol/L lower LDL cholesterol showed associations with increased fasting glucose (0·09 mmol/L, 95% CI 0·02 to 0·15), bodyweight (1·03 kg, 0·24 to 1·82), waist-to-hip ratio (0·006, 0·003 to 0·010), and an odds ratio for type diabetes of 1·29 (1·11 to 1·50). Based on the collected data, we did not identify associations with HbA1c (0·03%, -0·01 to 0·08), fasting insulin (0·00%, -0·06 to 0·07), and BMI (0·11 kg/m2, -0·09 to 0·30). Interpretation: . PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefits of PCSK9 inhibi
Published: 2016
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166. Capturing clinician-client interaction: development of the 4D&4R observational tool

Author: Rollans, M, Meade, T, Schmied, V, and Kemp, L
Subjects: Researcher-Subject Relations, Data Collection, Australia, Humans, Nursing Methodology Research, Nurse-Patient Relations, Qualitative Research
Abstract: AIM: To report on the development of an observation tool that can help a single researcher to collect field data about clinician and client interactions. BACKGROUND: Qualitative studies from a range of disciplines investigate the dynamics of interactions between clinicians and clients. These studies share and report findings but rarely provide details on the practical challenges and methods involved in managing such interactions when collecting rich ethnographic data. REVIEW METHODS: Development of the observational tool was informed by the study's requirements and context, previous research, and the authors cross-disciplinary knowledge and experience. DISCUSSION: In relation to how clinicians interact with clients and how clients respond, four domains have been identified and integrated into the observational tool. These domains act as prompts during observations of interactions between clients and nurses. Use of the tool has indicated its effectiveness in assisting with observations and the recording of field notes. CONCLUSION: The article shows how to develop a tool for qualitative field-data collection. The method can be adapted to studies that require observations of interactions and its components can be modified to suit their fields of study. IMPLICATIONS FOR PRACTICE OR RESEARCH: The 4D&4R tool discussed in this article provides indicators of clinician-client interactions and is transferable to other research and practice contexts
Published: 2013

167. Cholesterol, diastolic blood pressure and stroke: 13.000 strokes in 450.000 people in 45 prospective cohorts

Author: Qizilbash, N., Lewington, S., Duffy, S, Peto, R., Smith, T., Spiegelhalter, D., Iso, H., Shimamoto, T., Komachi, Y., Iida, M., Doyle, J., Strogatz, D., Ebrahim, S., Wannamethee, G., Whincup, P., Burke, V., Cullen, K., Knuiman, M., Welborn, T., Bainton, D., Baker, I., Elwood, P., Sweetnam, P., Yarnell, J., Keil, J., Sutherland, S., Hames, C., Tyroler, H., DAgostino, R., Kannel, W., Wolf, P., Aromaa, A., Knekt, P., Maatela, J., Reunanen, A., Puska, P., Sarti, C., Tamminen, M., Tuomilehto, J., Vartiainen, E., Bengtsson, C., Bjorkelund, C., Lissner, L., Kodama, K., Shimizu, Y., Kagan, A., Popper, J., Reed, D., Yano, K., Goldbourt, U., Medalie, J., Yaari, S., Criqui, M., Davis, C., Blackburn, Henry, Jacobs, D., Leupker, R., Harris, T., Madans, J., Ofstedal, M., Bjartveit, K., Stensvold, I., Tverdal, A., Garrow, K., Meade, T., Ruddock, V., Haheim, L., Hjermann, I., Holme, I., Leren, P., Cambien, F., Ducimetiere, P., Richard, J., Assmann, G., BarrettConnor, E., Langer, R., Gillis, C., Hart, C., Hawthorne, V., Hole D., Isles, C., Lever, A., Smith, G. D., Aravanis, C., Buzina, Ratko, Dontas, A., Fidanza, F., Giampaoli, S., Karvonen, M., Keys, Ancel, Kromhout, D., Lanti, M., Menotti, Alessandro, Mohaček, Ivan, Nedeljković, S., Nissinen, A., Punsar, S., Seccareccia, F., Toshima, H., Chen, Z., Collins, R., Li, W., Lu, J., Date, C., Nakayama, T., Tanaka, H., Yokoyama, T., Yoshiike, N., Brown, C., TunstallPedoe, H., Higgins, M., Keller, J., Carstensen, J., Tornberg, S., Marmot, M., and Shipley, M.
Subjects: medicine.medical_specialty, Cholesterol, business.industry, Incidence (epidemiology), Vakgroep Gezondheidsleer, General Medicine, medicine.disease, Prehypertension, Middle age, Environmental and Occupational Health Group, Surgery, chemistry.chemical_compound, Blood pressure, chemistry, Seven Countries Study, cholesterol, diastolic blood pressure, stroke, seven countries study, Internal medicine, Relative risk, medicine, Cardiology, Life Science, cardiovascular diseases, business, Stroke
Abstract: Individual studies of stroke have not clearly answered two questions: on the relation, if any, between total blood cholesterol and stroke ; and on how the strength of the relation between diastolic blood pressure and stroke varies with age. The associations of blood cholesterol and diastolic blood pressure with subsequent stroke rates were investigated by review of 45 prospective observational cohorts involving 450 000 individuals with 5-30 years of follow-up (mean 16 years, total 7·3 million person-years of observation), during which 13 397 participants were recorded as having had a stroke. Most of these were fatal strokes in studies that recorded only mortality and not incidence, but about one- quarter were from studies that recorded both fatal and non-fatal strokes. After standardisation for age, there was no association between blood cholesterol and stroke except, perhaps, in those under 45 years of age when screened. This lack of association was not influenced by adjustment for sex, diastolic blood pressure, history of coronary heart disease, or ethnicity (Asian or non-Asian). However, because the types of the strokes were not centrally available, the lack of any overall relation might conceal a positive association with ischaemic stroke together with a negative association with haemorrhagic stroke. When the highest and the lowest of the six blood pressure categories were compared, the difference in usual diastolic blood pressure was 27 mm Hg (102 vs 75 mm Hg), and there was a fivefold difference in stroke risk. This fivefold difference was seen both in those with a pre-existing history of coronary heart disease and in those without it. The proportional difference in stroke risk, however, was more extreme in middle than in old age. Among those aged
Published: 1996
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168. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

Author: Mihaylova, B., Emberson, J., Blackwell, L., Keech, A., Simes, J., Barnes, E.H., Voysey, M., Gray, A., Collins, R., Baigent, C., Lemos, J. de, Braunwald, E., Blazing, M., Murphy, S., Downs, J.R., Gotto, A., Clearfield, M., Holdaas, H., Gordon, D., Davis, B., Koren, M., Dahlof, B., Poulter, N., Sever, P., Knopp, R.H., Fellstrom, B., Jardine, A., Schmieder, R., Zannad, F., Goldbourt, U., Kaplinsky, E., Colhoun, H.M., Betteridge, D.J., Durrington, P.N., Hitman, G.A., Fuller, J., Neil, A., Wanner, C., Krane, V., Sacks, F., Moye, L., Pfeffer, M., Hawkins, C.M., Kjekshus, J., Wedel, H., Wikstrand, J., Barter, P., Tavazzi, L., Maggioni, A., Marchioli, R., Tognoni, G., Franzosi, M.G., Bloomfield, H., Robins, S., Armitage, J., Parish, S., Peto, R., Sleight, P., Pedersen, T.R., Ridker, P.M., Holman, R., Meade, T., MacMahon, S., Marschner, I., Tonkin, A., Shaw, J., Serruys, P.W., Nakamura, H., Knatterud, G., Furberg, C., Byington, R., Macfarlane, P., Cobbe, S., Ford, I., Murphy, M., Blauw, G.J., Packard, C., Shepherd, J., Pedersen, T., Wilhelmsen, L., Cannon, C., Bowman, L., Landray, M., Rosa, J. la, Rossouw, J., Probstfield, J., and Cholesterol Treatment Trialists
Published: 2012

169. TRACHEAL REPTURE AND ATLANTO-OCCIPITAL DISLOCATION

Author: Stephen Z. Turney and Meade T. Palmer
Subjects: medicine.medical_specialty, business.industry, Tracheal rupture, Respiratory disease, Anatomy, Critical Care and Intensive Care Medicine, medicine.disease, Cervical spine, Surgery, Atlanto-occipital dislocation, Skull, medicine.anatomical_structure, Blunt trauma, Dislocation (syntax), medicine, business
Abstract: Blunt trauma associated with tracheal rupture (TR) or atlanto-occipital dislocation (AOD) occurs rarely. Survival after sustaining either injury is even more uncommon. We describe a case of a patient who remarkably survived both injuries concurrently.
Published: 1994
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170. Authors' reply on aspirin for primary prevention

Author: Meade, T W. and Brennan, P J.
Subjects: Aspirin -- Health aspects, Coronary heart disease -- Prevention, Health, Prevention, Health aspects
Abstract: EDITOR--By implying disagreements with our study[1] which are largely misplaced or non-existent, Ramsay et al may have confused doctors who are deciding about aspirin in the primary prevention of coronary [...]
Published: 2001

171. Determination of who may derive most benefit from aspirin in primary prevention: subgroup results from a randomised controlled trial

Author: Meade, T W. and Brennan, P J.
Subjects: Aspirin -- Health aspects, Heart attack -- Prevention, Stroke (Disease) -- Prevention, Health, Prevention, Health aspects
Abstract: Objective To determine which groups of patients may derive particular benefit or experience harm from the use of low dose aspirin for the primary prevention of coronary heart disease. Design [...]
Published: 2000

172. Covariate-adjusted measures of discrimination for survival data

Author: White, Ian R., Rapsomaniki, Eleni, Wannamethee, S. G., Morris, R. W., Willeit, J., Willeit, P., Santer, P., Kiechl, S., Wald, N., Ebrahim, S., Lawlor, D. A., Gallacher, J., Yarnell, J. W G, Ben-Shlomo, Y., Casiglia, E., Tikhonoff, V., Sutherland, S. E., Nietert, P. J., Keil, J. E., Bachman, D. L., Psaty, B. M., Cushman, M., Nordestgaard, B. G., Tybjærg-Hansen, A., Frikke-Schmidt, R., Giampaoli, S., Palmieri, L., Panico, S., Pilotto, L., Vanuzzo, D., Simons, L. A., Friedlander, Y., McCallum, J., Price, J. F., McLachlan, S., Taylor, J. O., Guralnik, J. M., Wallace, R. B., Kohout, F. J., Cornoni-Huntley, J. C., Blazer, D. G., Phillips, C. L., Wareham, N. J., Khaw, K. T., Brenner, H., Schöttker, B., Müller, H. T., Rothenbacher, D., Nissinen, A., Donfrancesco, C., Harald, K., Jousilahti, P. R., Vartiainen, E., Salomaa, V., D'Agostino, R. B., Wolf, P. A., Vasan, R. S., Daimon, M., Oizumi, T., Kayama, T., Kato, T., Chetrit, A., Dankner, R., Lubin, F., Welin, L., Svärdsudd, K., Eriksson, H., Lappas, G., Lissner, L., Mehlig, K., Björkelund, C., Nagel, D., Kiyohara, Y., Arima, H., Ninomiya, T., Hata, J., Rodriguez, B., Dekker, J. M., Nijpels, G., Stehouwer, C. D A, Iso, H., Kitamura, A., Yamagishi, K., Noda, H., Goldbourt, U., Kauhanen, J., Salonen, J. T., Tuomainen, T. P., Meade, T. W., DeStavola, B. L., Blokstra, A., Verschuren, W. M M, de Boer, I. H., Folsom, A. R., Koenig, W., Meisinger, C., Peters, A., Bueno-de-Mesquita, H. B., Rosengren, A., Wilhelmsen, L., Kuller, L. H., Grandits, G., Cooper, J. A., Bauer, K. A., Davidson, K. W., Kirkland, S., Shaffer, J. A., Shimbo, D., Sato, S., Dullaart, R. P F, Bakker, S. J L, Gansevoort, R. T., Ducimetiere, P., Amouyel, P., Arveiler, D., Evans, A., Ferrières, J., Schulte, H., Assmann, G., Jukema, J. W., Westendorp, R. G J, Sattar, N., Cantin, B., Lamarche, B., Després, J. P., E.Barrett-Connor, Wingard, D. L., Daniels, L. B., Gudnason, V., Aspelund, T., Trevisan, M., Hofman, A., Franco, O. H., Tunstall-Pedoe, H., Tavendale, R., Lowe, G. D O, Woodward, M., Howard, W. J., Howard, B. V., Zhang, Y., Best, L. G., Umans, J., Davey-Smith, G., Onat, A., Nakagawa, H., Sakurai, M., Nakamura, K., Morikawa, Y., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., Sundström, J., Gaziano, J. M., Ridker, P. M., Marmot, M., Clarke, R., Collins, R., Fletcher, A., Brunner, E., Shipley, M., Kivimaki, M., Buring, J., Rifai, N., Cook, N., Ford, I., Robertson, M., Marín Ibañez, A., Feskens, E. J M, Geleijnse, J. M., White, Ian R., Rapsomaniki, Eleni, Wannamethee, S. G., Morris, R. W., Willeit, J., Willeit, P., Santer, P., Kiechl, S., Wald, N., Ebrahim, S., Lawlor, D. A., Gallacher, J., Yarnell, J. W G, Ben-Shlomo, Y., Casiglia, E., Tikhonoff, V., Sutherland, S. E., Nietert, P. J., Keil, J. E., Bachman, D. L., Psaty, B. M., Cushman, M., Nordestgaard, B. G., Tybjærg-Hansen, A., Frikke-Schmidt, R., Giampaoli, S., Palmieri, L., Panico, S., Pilotto, L., Vanuzzo, D., Simons, L. A., Friedlander, Y., McCallum, J., Price, J. F., McLachlan, S., Taylor, J. O., Guralnik, J. M., Wallace, R. B., Kohout, F. J., Cornoni-Huntley, J. C., Blazer, D. G., Phillips, C. L., Wareham, N. J., Khaw, K. T., Brenner, H., Schöttker, B., Müller, H. T., Rothenbacher, D., Nissinen, A., Donfrancesco, C., Harald, K., Jousilahti, P. R., Vartiainen, E., Salomaa, V., D'Agostino, R. B., Wolf, P. A., Vasan, R. S., Daimon, M., Oizumi, T., Kayama, T., Kato, T., Chetrit, A., Dankner, R., Lubin, F., Welin, L., Svärdsudd, K., Eriksson, H., Lappas, G., Lissner, L., Mehlig, K., Björkelund, C., Nagel, D., Kiyohara, Y., Arima, H., Ninomiya, T., Hata, J., Rodriguez, B., Dekker, J. M., Nijpels, G., Stehouwer, C. D A, Iso, H., Kitamura, A., Yamagishi, K., Noda, H., Goldbourt, U., Kauhanen, J., Salonen, J. T., Tuomainen, T. P., Meade, T. W., DeStavola, B. L., Blokstra, A., Verschuren, W. M M, de Boer, I. H., Folsom, A. R., Koenig, W., Meisinger, C., Peters, A., Bueno-de-Mesquita, H. B., Rosengren, A., Wilhelmsen, L., Kuller, L. H., Grandits, G., Cooper, J. A., Bauer, K. A., Davidson, K. W., Kirkland, S., Shaffer, J. A., Shimbo, D., Sato, S., Dullaart, R. P F, Bakker, S. J L, Gansevoort, R. T., Ducimetiere, P., Amouyel, P., Arveiler, D., Evans, A., Ferrières, J., Schulte, H., Assmann, G., Jukema, J. W., Westendorp, R. G J, Sattar, N., Cantin, B., Lamarche, B., Després, J. P., E.Barrett-Connor, Wingard, D. L., Daniels, L. B., Gudnason, V., Aspelund, T., Trevisan, M., Hofman, A., Franco, O. H., Tunstall-Pedoe, H., Tavendale, R., Lowe, G. D O, Woodward, M., Howard, W. J., Howard, B. V., Zhang, Y., Best, L. G., Umans, J., Davey-Smith, G., Onat, A., Nakagawa, H., Sakurai, M., Nakamura, K., Morikawa, Y., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., Sundström, J., Gaziano, J. M., Ridker, P. M., Marmot, M., Clarke, R., Collins, R., Fletcher, A., Brunner, E., Shipley, M., Kivimaki, M., Buring, J., Rifai, N., Cook, N., Ford, I., Robertson, M., Marín Ibañez, A., Feskens, E. J M, and Geleijnse, J. M.
Published: 2015

173. Covariate-adjusted measures of discrimination for survival data

Author: AIOS Psychiatrie, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS MDL 1, Cancer, Affectieve & Psychotische Med., White, Ian R., Rapsomaniki, Eleni, Wannamethee, S. G., Morris, R. W., Willeit, J., Willeit, P., Santer, P., Kiechl, S., Wald, N., Ebrahim, S., Lawlor, D. A., Gallacher, J., Yarnell, J. W G, Ben-Shlomo, Y., Casiglia, E., Tikhonoff, V., Sutherland, S. E., Nietert, P. J., Keil, J. E., Bachman, D. L., Psaty, B. M., Cushman, M., Nordestgaard, B. G., Tybjærg-Hansen, A., Frikke-Schmidt, R., Giampaoli, S., Palmieri, L., Panico, S., Pilotto, L., Vanuzzo, D., Simons, L. A., Friedlander, Y., McCallum, J., Price, J. F., McLachlan, S., Taylor, J. O., Guralnik, J. M., Wallace, R. B., Kohout, F. J., Cornoni-Huntley, J. C., Blazer, D. G., Phillips, C. L., Wareham, N. J., Khaw, K. T., Brenner, H., Schöttker, B., Müller, H. T., Rothenbacher, D., Nissinen, A., Donfrancesco, C., Harald, K., Jousilahti, P. R., Vartiainen, E., Salomaa, V., D'Agostino, R. B., Wolf, P. A., Vasan, R. S., Daimon, M., Oizumi, T., Kayama, T., Kato, T., Chetrit, A., Dankner, R., Lubin, F., Welin, L., Svärdsudd, K., Eriksson, H., Lappas, G., Lissner, L., Mehlig, K., Björkelund, C., Nagel, D., Kiyohara, Y., Arima, H., Ninomiya, T., Hata, J., Rodriguez, B., Dekker, J. M., Nijpels, G., Stehouwer, C. D A, Iso, H., Kitamura, A., Yamagishi, K., Noda, H., Goldbourt, U., Kauhanen, J., Salonen, J. T., Tuomainen, T. P., Meade, T. W., DeStavola, B. L., Blokstra, A., Verschuren, W. M M, de Boer, I. H., Folsom, A. R., Koenig, W., Meisinger, C., Peters, A., Bueno-de-Mesquita, H. B., Rosengren, A., Wilhelmsen, L., Kuller, L. H., Grandits, G., Cooper, J. A., Bauer, K. A., Davidson, K. W., Kirkland, S., Shaffer, J. A., Shimbo, D., Sato, S., Dullaart, R. P F, Bakker, S. J L, Gansevoort, R. T., Ducimetiere, P., Amouyel, P., Arveiler, D., Evans, A., Ferrières, J., Schulte, H., Assmann, G., Jukema, J. W., Westendorp, R. G J, Sattar, N., Cantin, B., Lamarche, B., Després, J. P., E.Barrett-Connor, Wingard, D. L., Daniels, L. B., Gudnason, V., Aspelund, T., Trevisan, M., Hofman, A., Franco, O. H., Tunstall-Pedoe, H., Tavendale, R., Lowe, G. D O, Woodward, M., Howard, W. J., Howard, B. V., Zhang, Y., Best, L. G., Umans, J., Davey-Smith, G., Onat, A., Nakagawa, H., Sakurai, M., Nakamura, K., Morikawa, Y., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., Sundström, J., Gaziano, J. M., Ridker, P. M., Marmot, M., Clarke, R., Collins, R., Fletcher, A., Brunner, E., Shipley, M., Kivimaki, M., Buring, J., Rifai, N., Cook, N., Ford, I., Robertson, M., Marín Ibañez, A., Feskens, E. J M, Geleijnse, J. M., AIOS Psychiatrie, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS MDL 1, Cancer, Affectieve & Psychotische Med., White, Ian R., Rapsomaniki, Eleni, Wannamethee, S. G., Morris, R. W., Willeit, J., Willeit, P., Santer, P., Kiechl, S., Wald, N., Ebrahim, S., Lawlor, D. A., Gallacher, J., Yarnell, J. W G, Ben-Shlomo, Y., Casiglia, E., Tikhonoff, V., Sutherland, S. E., Nietert, P. J., Keil, J. E., Bachman, D. L., Psaty, B. M., Cushman, M., Nordestgaard, B. G., Tybjærg-Hansen, A., Frikke-Schmidt, R., Giampaoli, S., Palmieri, L., Panico, S., Pilotto, L., Vanuzzo, D., Simons, L. A., Friedlander, Y., McCallum, J., Price, J. F., McLachlan, S., Taylor, J. O., Guralnik, J. M., Wallace, R. B., Kohout, F. J., Cornoni-Huntley, J. C., Blazer, D. G., Phillips, C. L., Wareham, N. J., Khaw, K. T., Brenner, H., Schöttker, B., Müller, H. T., Rothenbacher, D., Nissinen, A., Donfrancesco, C., Harald, K., Jousilahti, P. R., Vartiainen, E., Salomaa, V., D'Agostino, R. B., Wolf, P. A., Vasan, R. S., Daimon, M., Oizumi, T., Kayama, T., Kato, T., Chetrit, A., Dankner, R., Lubin, F., Welin, L., Svärdsudd, K., Eriksson, H., Lappas, G., Lissner, L., Mehlig, K., Björkelund, C., Nagel, D., Kiyohara, Y., Arima, H., Ninomiya, T., Hata, J., Rodriguez, B., Dekker, J. M., Nijpels, G., Stehouwer, C. D A, Iso, H., Kitamura, A., Yamagishi, K., Noda, H., Goldbourt, U., Kauhanen, J., Salonen, J. T., Tuomainen, T. P., Meade, T. W., DeStavola, B. L., Blokstra, A., Verschuren, W. M M, de Boer, I. H., Folsom, A. R., Koenig, W., Meisinger, C., Peters, A., Bueno-de-Mesquita, H. B., Rosengren, A., Wilhelmsen, L., Kuller, L. H., Grandits, G., Cooper, J. A., Bauer, K. A., Davidson, K. W., Kirkland, S., Shaffer, J. A., Shimbo, D., Sato, S., Dullaart, R. P F, Bakker, S. J L, Gansevoort, R. T., Ducimetiere, P., Amouyel, P., Arveiler, D., Evans, A., Ferrières, J., Schulte, H., Assmann, G., Jukema, J. W., Westendorp, R. G J, Sattar, N., Cantin, B., Lamarche, B., Després, J. P., E.Barrett-Connor, Wingard, D. L., Daniels, L. B., Gudnason, V., Aspelund, T., Trevisan, M., Hofman, A., Franco, O. H., Tunstall-Pedoe, H., Tavendale, R., Lowe, G. D O, Woodward, M., Howard, W. J., Howard, B. V., Zhang, Y., Best, L. G., Umans, J., Davey-Smith, G., Onat, A., Nakagawa, H., Sakurai, M., Nakamura, K., Morikawa, Y., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., Sundström, J., Gaziano, J. M., Ridker, P. M., Marmot, M., Clarke, R., Collins, R., Fletcher, A., Brunner, E., Shipley, M., Kivimaki, M., Buring, J., Rifai, N., Cook, N., Ford, I., Robertson, M., Marín Ibañez, A., Feskens, E. J M, and Geleijnse, J. M.
Published: 2015

174. The motherhood choices decision aid for women with rheumatoid arthritis increases knowledge and reduces decisional conflict: a randomized controlled trial

Author: Meade, T., primary, Dowswell, E., additional, Manolios, N., additional, and Sharpe, L., additional
Published: 2015
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175. Patients were more satisfied with chiropractic than other treatments for low back pain

Author: Meade, T W.
Subjects: Chiropractic -- Health aspects -- Evaluation, Patient satisfaction -- Evaluation -- Health aspects, Backache -- Care and treatment, Health, Care and treatment, Evaluation, Health aspects
Abstract: EDITOR--Patient satisfaction is increasingly recognised as an important outcome in trials. Whatever interpretation Ernst and Assendelft place on changes in the Oswestry score, they did not mention in their letter[1] [...]
Published: 1999

176. Is recruitment more difficult with a placebo arm in randomised controlled trials? A quasirandomised, interview based study

Author: Welton, A J., Vickers, M R., Cooper, J A., Meade, T W., and Marteau, T M.
Subjects: Health
Abstract: Abstract Objective To investigate whether including a placebo arm in a clinical trial of hormone replacement therapy influenced women's stated willingness to participate. Design Quasirandomised, interview based study. Setting 10 [...]
Published: 1999

177. Cost-effectiveness of preventing loss to follow-up in HIV treatment programs : a Côte d'Ivoire appraisal

Author: Losina, E., Touré, H., Uhler, L.M., Anglaret, X., Paltiel, A.D., Balestre, E., Walensky, R.P., Messou, E., Weinstein, M.C., Dabis, F., Freedberg, K.A., Anastos, K., Bangsberg, D., Boulle, A., Chisanga, J., Delaporte, Eric, Dickinson, D., Ekong, E., El Filali, K.M., Hosseinipour, M., Kimaiyo, S., Khongphatthanayothin, M., Kumarasamy, N., Laurent, Christian, Luthy, R., McIntyre, J., Meade, T., Nash, D., Mokaya, W.N., Pascoe, M., Pepper, L., Sow, P.S., Phiri, S., Shechter, M., Sidle, J., Sprinz, E., Tonwe-Gold, B., Touré, S., Van der Borght, S., Weigel, R., and Wood, R.
Subjects: TRAITEMENT MEDICAL, MALADIES ASSOCIEES, SIDA, ESPERANCE DE VIE, ETUDE DE FAISABILITE, ECONOMIE DE LA SANTE, COUT, PREVENTION SANITAIRE, ANALYSE COUT AVANTAGES, THERAPIE ANTIRETROVIRALE
Published: 2009

178. What should we tell people?

Author: Meade, T. W., primary
Published: 1981
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179. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Author: Holmes, M.V. (Michael), Dale, C.E. (Caroline), Zuccolo, L. (Luisa), Silverwood, R.J. (Richard), Guo, Y. (Yongli), Ye, Z. (Zheng), Prieto-Merino, D. (David), Dehghan, A. (Abbas), Trompet, S. (Stella), Wong, A. (Andrew), Cavadino, A. (Alana), Drogan, D. (Dagmar), Padmanabhan, S. (Sandosh), Li, S. (Shanshan), Yesupriya, A. (Ajay), Leusink, M. (Maarten), Sundstrom, J. (Johan), Hubacek, J.A. (Jaroslav A.), Pikhart, H. (Hynek), Swerdlow, D.I. (Daniel), Panayiotou, A.G. (Andrie), Borinskaya, S.A. (Svetlana), Finan, C. (Chris), Shah, S. (Sonia), Kuchenbaecker, K.B. (Karoline), Shah, T. (Tina), Engmann, J. (Jorgen), Folkersen, L. (Lasse), Eriksson, P. (Per), Ricceri, F. (Fulvio), Melander, O. (Olle), Sacerdote, C. (Carlotta), Gamble, D.M. (Dale), Rayaprolu, S. (Sruti), Ross, O.A. (Owen), McLachlan, S. (Stela), Vikhireva, O. (Olga), Sluijs, I., Scott, R.A. (Robert), Adamkova, V. (Vera), Flicker, L. (Leon), Bockxmeer, F.M. (Frank) van, Power, C. (Christine), Marques-Vidal, P. (Pedro), Meade, T. (Tom), Marmot, M. (Michael), Ferro, M.T. (María), Paulos-Pinheiro, S. (Sofia), Humphries, S.E. (Steve), Talmud, P.J., Leach, I.M. (Irene Mateo), Verweij, N. (Niek), Linneberg, A. (Allan), Skaaby, T. (Tea), Doevendans, P.A. (Pieter), Cramer, M.-J. (Maarten-Jan), Harst, P. (Pim) van der, Klungel, O.H. (Olaf), Dowling, N. (Nicole), Dominiczak, A. (Anna), Kumari, M. (Meena), Nicolaides, A.N. (Andrew), Weikert, C. (Cornelia), Boeing, H. (Heiner), Ebrahim, S. (Shanil), Gaunt, T.R. (Tom), Price, J.F. (Jackie F.), Lannfelt, L. (Lars), Peasey, A. (Anne), Kubinova, R., Pajak, A. (Andrzej), Malyutina, S., Voevoda, M.I. (Mikhail), Tamosiunas, A. (Abdonas), Maitland-van der Zee, A-H. (Anke-Hilse), Norman, P.E. (Paul), Hankey, G.J. (Graeme), Bergmann, M.M. (Manuela), Hofman, A. (Albert), Franco, O.H. (Oscar), Cooper, J. (Jim), Palmen, J. (Jutta), Spiering, W. (Wilko), Jong, P.A. (Pim) de, Kuh, D. (Diana), Hardy, R., Uitterlinden, A.G. (André), Ikram, M.A. (Arfan), Ford, I. (Ian), Hyppönen, E. (Elina), Almeida, O.P. (Osvaldo), Wareham, N.J. (Nick), Khaw, K-T. (Kay-Tee), Hamsten, A. (Anders), Husemoen, L.L.N. (Lise Lotte), Tjønneland, A. (Anne), Tolstrup, J.S. (Janne), Rimm, E., Beulens, J.W.J. (Joline), Verschuren, W.M.M. (W. M. Monique), Onland-Moret, N.C. (Charlotte), Hofker, M.A. (Marten), Wannamethee, S.G. (Goya), Whincup, P.H. (Peter), Morris, R.W. (Richard), Vicente, A.M. (Astrid), Watkins, H. (Hugh), Farrall, M. (Martin), Jukema, J.W. (Jan Wouter), Meschia, J.F. (James F.), Cupples, L.A. (Adrienne), Sharp, S.J. (Stephen), Fornage, M. (Myriam), Kooperberg, C. (Charles), LaCroix, A.Z. (Andrea), Dai, J.Y. (James), Lanktree, M.B. (Matthew), Siscovick, D.S. (David), Jorgenson, E. (Eric), Spring, B. (Bonnie), Coresh, J. (Josef), Li, Y.R. (Yun), Buxbaum, S.G. (Sarah), Schreiner, P.J. (Pamela), Ellison, D.H. (David), Tsai, M.Y. (Michael), Patel, S.R. (Sanjay), Redline, S. (Susan), Johnson, A.D. (Andrew), Hoogeveen, R.C. (Ron), Hakonarson, H. (Hakon), Rotter, J.I. (Jerome), Boerwinkle, E.A. (Eric), Bakker, P.I.W. (Paul) de, Kivimaki, M. (Mika), Asselbergs, F.W. (Folkert), Sattar, N. (Naveed), Lawlor, D.A. (Debbie), Whittaker, J. (John), Smith, A.V. (Davey), Mukamal, K. (Kenneth), Psaty, B.M. (Bruce), Wilson, J.G. (James), Lange, L.A. (Leslie), Hamidovic, A. (Ajna), Nordestgaard, B.G. (Børge), Bobak, M. (Martin), Leon, D.A. (David), Langenberg, C. (Claudia), Palmer, T.M. (Tom), Reiner, A.P. (Alex), Keating, J. (John), Dudbridge, F. (Frank), Casas, J.P. (Juan), Holmes, M.V. (Michael), Dale, C.E. (Caroline), Zuccolo, L. (Luisa), Silverwood, R.J. (Richard), Guo, Y. (Yongli), Ye, Z. (Zheng), Prieto-Merino, D. (David), Dehghan, A. (Abbas), Trompet, S. (Stella), Wong, A. (Andrew), Cavadino, A. (Alana), Drogan, D. (Dagmar), Padmanabhan, S. (Sandosh), Li, S. (Shanshan), Yesupriya, A. (Ajay), Leusink, M. (Maarten), Sundstrom, J. (Johan), Hubacek, J.A. (Jaroslav A.), Pikhart, H. (Hynek), Swerdlow, D.I. (Daniel), Panayiotou, A.G. (Andrie), Borinskaya, S.A. (Svetlana), Finan, C. (Chris), Shah, S. (Sonia), Kuchenbaecker, K.B. (Karoline), Shah, T. (Tina), Engmann, J. (Jorgen), Folkersen, L. (Lasse), Eriksson, P. (Per), Ricceri, F. (Fulvio), Melander, O. (Olle), Sacerdote, C. (Carlotta), Gamble, D.M. (Dale), Rayaprolu, S. (Sruti), Ross, O.A. (Owen), McLachlan, S. (Stela), Vikhireva, O. (Olga), Sluijs, I., Scott, R.A. (Robert), Adamkova, V. (Vera), Flicker, L. (Leon), Bockxmeer, F.M. (Frank) van, Power, C. (Christine), Marques-Vidal, P. (Pedro), Meade, T. (Tom), Marmot, M. (Michael), Ferro, M.T. (María), Paulos-Pinheiro, S. (Sofia), Humphries, S.E. (Steve), Talmud, P.J., Leach, I.M. (Irene Mateo), Verweij, N. (Niek), Linneberg, A. (Allan), Skaaby, T. (Tea), Doevendans, P.A. (Pieter), Cramer, M.-J. (Maarten-Jan), Harst, P. (Pim) van der, Klungel, O.H. (Olaf), Dowling, N. (Nicole), Dominiczak, A. (Anna), Kumari, M. (Meena), Nicolaides, A.N. (Andrew), Weikert, C. (Cornelia), Boeing, H. (Heiner), Ebrahim, S. (Shanil), Gaunt, T.R. (Tom), Price, J.F. (Jackie F.), Lannfelt, L. (Lars), Peasey, A. (Anne), Kubinova, R., Pajak, A. (Andrzej), Malyutina, S., Voevoda, M.I. (Mikhail), Tamosiunas, A. (Abdonas), Maitland-van der Zee, A-H. (Anke-Hilse), Norman, P.E. (Paul), Hankey, G.J. (Graeme), Bergmann, M.M. (Manuela), Hofman, A. (Albert), Franco, O.H. (Oscar), Cooper, J. (Jim), Palmen, J. (Jutta), Spiering, W. (Wilko), Jong, P.A. (Pim) de, Kuh, D. (Diana), Hardy, R., Uitterlinden, A.G. (André), Ikram, M.A. (Arfan), Ford, I. (Ian), Hyppönen, E. (Elina), Almeida, O.P. (Osvaldo), Wareham, N.J. (Nick), Khaw, K-T. (Kay-Tee), Hamsten, A. (Anders), Husemoen, L.L.N. (Lise Lotte), Tjønneland, A. (Anne), Tolstrup, J.S. (Janne), Rimm, E., Beulens, J.W.J. (Joline), Verschuren, W.M.M. (W. M. Monique), Onland-Moret, N.C. (Charlotte), Hofker, M.A. (Marten), Wannamethee, S.G. (Goya), Whincup, P.H. (Peter), Morris, R.W. (Richard), Vicente, A.M. (Astrid), Watkins, H. (Hugh), Farrall, M. (Martin), Jukema, J.W. (Jan Wouter), Meschia, J.F. (James F.), Cupples, L.A. (Adrienne), Sharp, S.J. (Stephen), Fornage, M. (Myriam), Kooperberg, C. (Charles), LaCroix, A.Z. (Andrea), Dai, J.Y. (James), Lanktree, M.B. (Matthew), Siscovick, D.S. (David), Jorgenson, E. (Eric), Spring, B. (Bonnie), Coresh, J. (Josef), Li, Y.R. (Yun), Buxbaum, S.G. (Sarah), Schreiner, P.J. (Pamela), Ellison, D.H. (David), Tsai, M.Y. (Michael), Patel, S.R. (Sanjay), Redline, S. (Susan), Johnson, A.D. (Andrew), Hoogeveen, R.C. (Ron), Hakonarson, H. (Hakon), Rotter, J.I. (Jerome), Boerwinkle, E.A. (Eric), Bakker, P.I.W. (Paul) de, Kivimaki, M. (Mika), Asselbergs, F.W. (Folkert), Sattar, N. (Naveed), Lawlor, D.A. (Debbie), Whittaker, J. (John), Smith, A.V. (Davey), Mukamal, K. (Kenneth), Psaty, B.M. (Bruce), Wilson, J.G. (James), Lange, L.A. (Leslie), Hamidovic, A. (Ajna), Nordestgaard, B.G. (Børge), Bobak, M. (Martin), Leon, D.A. (David), Langenberg, C. (Claudia), Palmer, T.M. (Tom), Reiner, A.P. (Alex), Keating, J. (John), Dudbridge, F. (Frank), and Casas, J.P. (Juan)
Published: 2014
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180. Thrombosis prevention trial: follow-up study of practical implications

Author: Fasey, N, Brennan, P J, and Meade, T W
Subjects: Male, Aspirin, Double-Blind Method, Anticoagulants, Humans, Female, Thrombosis, Warfarin, Family Practice, Platelet Aggregation Inhibitors, Research Article, Follow-Up Studies
Abstract: The impact of randomised controlled trials on subsequent practice has only occasionally been assessed. Doing so is particularly necessary when unusual and possibly controversial treatments are being used. The aim of this study was to assess the practical implications of the results of the placebo-controlled primary prevention thrombosis prevention trial, in which the active treatment regimens were combined warfarin and aspirin, warfarin alone, and aspirin alone. Both active agents were given in low doses. Decisions on post-trial management were sought about men who continued with randomly-allocated treatment until the trial ended. The results of the trial appeared to have influenced decisions about future management. While aspirin was clearly the most frequent choice, a regimen involving warfarin was also used for a substantial proportion of men. Prior experience of acceptability, effectiveness, and safety probably played a significant part in decisions to continue with or switch to a warfarin-containing regimen. The findings may provide a measure of reassurance about the value of oral anticoagulation in other settings, particularly atrial fibrillation where, despite the results of trials showing major reductions in stroke, anticoagulation is underused.
Published: 2002

181. The Edge of Danger: artificial lighting and the dialectics of domestic occupation in Philip Johnson's Glass and Guest Houses

Author: Diaz, L, Meade, T, Creed, I, Petty, Margaret, Diaz, L, Meade, T, Creed, I, and Petty, Margaret
Abstract: In the first half of the twentieth century the dematerializing of boundaries between enclosure and exposure problematized traditional acts of “occupation” and understandings of the domestic environment. As a space of escalating technological control, the modern domestic interior offered new potential to re-define the meaning and means of habitation. This shift is clearly expressed in the transformation of electric lighting technology and applications for the modern interior in the mid-twentieth century. Addressing these issues, this paper examines the critical role of electric lighting in regulating and framing both the public and private occupation of Philip Johnson’s New Canaan estate. Exploring the dialectically paired transparent Glass House and opaque Guest House (both 1949), this study illustrates how Johnson employed artificial light to control the visual environment of the estate as well as to aestheticize the performance of domestic space. Looking closely at the use of artificial light to create emotive effects as well as to intensify the experience of occupation, this revisiting of the iconic Glass House and lesser-known Guest House provides a more complex understanding of Johnson’s work and the means with which he inhabited his own architecture. Calling attention to the importance of Johnson serving as both architect and client, and his particular interest in exploring the new potential of architectural lighting in this period, this paper investigates Johnson’s use of electric light to support architectural narratives, maintain visual order and control, and to suit the nuanced desires of domestic occupation.
Published: 2013

182. Digging over that old ground: an Australian perspective of women's experience of psychosocial assessment and depression screening in pregnancy and following birth

Author: Rollans, M, Schmied, V, Kemp, L, Meade, T, Rollans, M, Schmied, V, Kemp, L, and Meade, T
Published: 2013

183. Negotiating policy in practice: child and family health nurses' approach to the process of postnatal psychosocial assessment

Author: Rollans, M, Schmied, V, Kemp, L, Meade, T, Rollans, M, Schmied, V, Kemp, L, and Meade, T
Published: 2013

184. 'We just ask some questions...' the process of antenatal psychosocial assessment by midwives

Author: Rollans, M, Schmied, V, Kemp, L, Meade, T, Rollans, M, Schmied, V, Kemp, L, and Meade, T
Published: 2013

185. Commentary: UK-PDS is well designed and clinically important

Author: Holman, R, Matthews, DR, Meade, T, and Grp, U
Published: 2001

186. Safeguards for research using large scale DNA collections. Study will not be started before suitable arrangements are in place

Author: Meade, T
Published: 2001

187. C-reactive protein, fibrinogen, and cardiovascular disease prediction

Author: Kaptoge, S. (Stephen), Angelantonio, E. (Emanuele) di, Pennells, L. (Lisa), Wood, A.M. (Angela), White, I.R. (Ian), Gao, P. (Pei), Walker, M. (Mark), Thompson, A. (Alexander), Sarwar, S. (Sheryar), Caslake, M. (Muriel), Butterworth, A.S. (Adam), Amouyel, P. (Philippe), Assmann, G. (Gerd), Bakker, S.J.L. (Stephan), Barr, E.L.M., Barrett-Connor, E. (Elizabeth), Benjamin, E.J. (Emelia), Björkelund, C. (Cecilia), Brenner, H. (Hermann), Brunner, E. (Eric), Clarke, R. (Robert), Cooper, J.A. (Jackie), Cremer, P., Cushman, M. (Mary Ann), Dagenais, G.R. (Gilles R), D'Agostino, R.B. (Ralph), Dankner, R. (Rachel), Davey-Smith, G. (George), Deeg, D.J.H. (Dorly), Dekker, J.M. (Jacqueline), Engström, G., Folsom, A.R. (Aaron), Fowkes, F.G.R. (F. Gerald R.), Gallacher, J. (John), Gaziano, J.M. (J. Michael), Giampaoli, S. (Simona), Gillum, R.F. (Richard), Hofman, A. (Albert), Howard, B.V. (Barbara), Ingelsson, E. (Erik), Iso, H. (Hiroyasu), Jorgensen, T. (Torben), Kiechl, S. (Stefan), Kitamura, A., Kiyohara, Y. (Yutaka), Koenig, W. (Wolfgang), Kromhout, D. (Daan), Kuller, L.H. (Lewis), Lawlor, D.A. (Debbie), Meade, T. (Tom), Nissinen, A. (Aulikki), Nordestgaard, B.G. (Børge), Onat, A. (Altan), Panagiotakos, D.B. (Demosthenes), Psaty, B.M. (Bruce), Rodriguez, B. (Beatriz), Rosengren, A. (Annika), Salomaa, V. (Veikko), Kauhanen, J. (Jussi), Salonen, J.T., Shaffer, J.A. (Jonathan), Shea, S. (Steven), Ford, I. (Ian), Stehouwer, C.D. (Coen), Strandberg, T.E. (Timo), Tipping, A. (Alex), Tosetto, A. (Alberto), Wassertheil-Smoller, S. (Sylvia), Wennberg, P. (Patrik), Westendorp, R.G.J. (Rudi), Whincup, P.H. (Peter), Wilhelmsen, L. (Lars), Woodward, M. (Mark), Lowe, G.D.O. (Gordon), Wareham, N.J. (Nick), Khaw, K-T. (Kay-Tee), Sattar, N. (Naveed), Packard, C. (Chris), Gudnason, V. (Vilmundur), Ridker, P.M. (Paul), Pepys, M.B. (Mark), Thompson, S.G. (Simon), Danesh, J. (John), Kaptoge, S. (Stephen), Angelantonio, E. (Emanuele) di, Pennells, L. (Lisa), Wood, A.M. (Angela), White, I.R. (Ian), Gao, P. (Pei), Walker, M. (Mark), Thompson, A. (Alexander), Sarwar, S. (Sheryar), Caslake, M. (Muriel), Butterworth, A.S. (Adam), Amouyel, P. (Philippe), Assmann, G. (Gerd), Bakker, S.J.L. (Stephan), Barr, E.L.M., Barrett-Connor, E. (Elizabeth), Benjamin, E.J. (Emelia), Björkelund, C. (Cecilia), Brenner, H. (Hermann), Brunner, E. (Eric), Clarke, R. (Robert), Cooper, J.A. (Jackie), Cremer, P., Cushman, M. (Mary Ann), Dagenais, G.R. (Gilles R), D'Agostino, R.B. (Ralph), Dankner, R. (Rachel), Davey-Smith, G. (George), Deeg, D.J.H. (Dorly), Dekker, J.M. (Jacqueline), Engström, G., Folsom, A.R. (Aaron), Fowkes, F.G.R. (F. Gerald R.), Gallacher, J. (John), Gaziano, J.M. (J. Michael), Giampaoli, S. (Simona), Gillum, R.F. (Richard), Hofman, A. (Albert), Howard, B.V. (Barbara), Ingelsson, E. (Erik), Iso, H. (Hiroyasu), Jorgensen, T. (Torben), Kiechl, S. (Stefan), Kitamura, A., Kiyohara, Y. (Yutaka), Koenig, W. (Wolfgang), Kromhout, D. (Daan), Kuller, L.H. (Lewis), Lawlor, D.A. (Debbie), Meade, T. (Tom), Nissinen, A. (Aulikki), Nordestgaard, B.G. (Børge), Onat, A. (Altan), Panagiotakos, D.B. (Demosthenes), Psaty, B.M. (Bruce), Rodriguez, B. (Beatriz), Rosengren, A. (Annika), Salomaa, V. (Veikko), Kauhanen, J. (Jussi), Salonen, J.T., Shaffer, J.A. (Jonathan), Shea, S. (Steven), Ford, I. (Ian), Stehouwer, C.D. (Coen), Strandberg, T.E. (Timo), Tipping, A. (Alex), Tosetto, A. (Alberto), Wassertheil-Smoller, S. (Sylvia), Wennberg, P. (Patrik), Westendorp, R.G.J. (Rudi), Whincup, P.H. (Peter), Wilhelmsen, L. (Lars), Woodward, M. (Mark), Lowe, G.D.O. (Gordon), Wareham, N.J. (Nick), Khaw, K-T. (Kay-Tee), Sattar, N. (Naveed), Packard, C. (Chris), Gudnason, V. (Vilmundur), Ridker, P.M. (Paul), Pepys, M.B. (Mark), Thompson, S.G. (Simon), and Danesh, J. (John)
Abstract: BACKGROUND: There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. METHODS: We analyzed data from 52 prospective studies that included 246,669 participants without a history of cardiovascular disease to investigate the value of adding CRP or fibrinogen levels to conventional risk factors for the prediction of cardiovascular risk. We calculated measures of discrimination and reclassification during follow-up and modeled the clinical implications of initiation of statin therapy after the assessment of CRP or fibrinogen. RESULTS: The addition of information on high-density lipoprotein cholesterol to a prognostic model for cardiovascular disease that included age, sex, smoking status, blood pressure, history of diabetes, and total cholesterol level increased the C-index, a measure of risk discrimination, by 0.0050. The further addition to this model of information on CRP or fibrinogen increased the C-index by 0.0039 and 0.0027, respectively (P<0.001), and yielded a net reclassification improvement of 1.52% and 0.83%, respectively, for the predicted 10-year risk categories of "low" (<10%), "intermediate" (10% to <20%), and "high" (≥20%) (P<0.02 for both comparisons). We estimated that among 100,000 adults 40 years of age or older, 15,025 persons would initially be classified as being at intermediate risk for a cardiovascular event if conventional risk factors alone were used to calculate risk. Assuming that statin therapy would be initiated in accordance with Adult Treatment Panel III guidelines (i.e., for persons with a predicted risk of ≥20% and for those with certain other risk factors, such as diabetes, irrespective of their 10-year predicted risk), additional targeted assessment of CRP or fibrinogen levels in the 13,199 remaining participants at intermediate risk could help prevent approximately 30 additional cardiovascular events over the course of 10 ye
Published: 2012
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188. Problem-solving versus cognitive restructuring of medically ill seniors with depression (PROMISE-D trial): Study protocol and design

Author: Sharpe, L., Gittins, C.B., Correia, H.M., Meade, T., Nicholas, M.K., Raue, P.J., McDonald, S., Areán, P.A., Sharpe, L., Gittins, C.B., Correia, H.M., Meade, T., Nicholas, M.K., Raue, P.J., McDonald, S., and Areán, P.A.
Abstract: With an ageing population in most Western countries, people are living longer but often with one or more chronic physical health problems. Older people in physically poor health are at greater risk of developing clinical depression. Cognitive Behavioural Therapy (CBT) and Problem Solving Therapy (PST) have both been found to be efficacious in treating late-life depression, however patients with "multi-morbidity" (i.e. more than one chronic condition) are often excluded from these trials. The aim of this study is to compare the efficacy of CBT and PST in treating older adults who have one or more chronic physical health conditions and a diagnosable depressive disorder. This study will be the first to explicitly target the treatment of depression in older people in primary care settings presenting with a range of health problems using behavioural interventions. The PROMISE-D study is a randomised controlled trial of two evidence-based treatments for late-life major or minor depression for patients who also have at least one co-morbid chronic health problem. Participants will be randomised to two active interventions (PST or CBT) or enhanced treatment-as-usual (E-TAU). Primary outcomes will be depression diagnostic status and severity of depression (according to the Hamilton Depression Rating Scale and the Geriatric Depression Scale). Secondary outcomes will be anxiety severity, quality of life and health care utilisation. Assessments will be conducted by a researcher who remains blind to the patient's treatment allocation and will be conducted pre and post-treatment and at six and 12 months follow-up. Health care utilisation will be assessed throughout a two year period following entry to the trial. Executive function, rumination and emotion regulation will also be measured to determine the impact of these factors on treatment response in two treatment groups. Multi-morbidity, the experience of two or more chronic health problems, is becoming an increasing problem int
Published: 2012

189. On location: The imagined private interior in public life

Author: Diaz, L, Meade, T, Hagan, S, Lee, Gini, Diaz, L, Meade, T, Hagan, S, and Lee, Gini
Abstract: This paper reveals the interior landscapes of selected contemporary Australian films, such as The Caterpillar Wish and Bad Boy Bubby, to develop a number of thematic influences on the manner in which domestic and private lives are constructed through filmic imagination. The research uncovers the conditions that contribute to particular scenographic representations of the humble interiors that act as both backdrop and performer to subtle and often troubled narratives. Such readings are informed by the theoretical works of writer Gertrude Stein, among others, who explore the relationships between the scenographic third dimension and the fourth dimensional performance in the representation of narrative space. A further theoretical thread lies in Giuliana Bruno’s work on the tension between private and public filmic space, which is explored through the public outing of intensely private spaces generated through narratives framed by the specificities of found interiors. Beyond the interrogation of qualities of imagined filmic space is the condition whereby locations, once transformed by the event of movie making are consequently forever revised. These altered conditions subsequently reinvest the lives of those who return to the location with layered narratives of occupation. Situationally, the now reconverted interior performs as contributor to subsequent private inhabitation, even if only as imagined space. The possibility here is that the qualities of the original may be superimposed and recontextualised to invest post-produced interiors with the qualities of the other space as imagined. This reading of film space explores new theoretical design scenarios for imagined and everyday interior landscapes.
Published: 2011

190. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.

Author: Baigent, C, Blackwell, L, Collins, R, Emberson, J, Godwin, J, Peto, R, Buring, J, Hennekens, C, Kearney, P, Meade, T, Patrono, Carlo, Roncaglioni, Mc, Zanchetti, A., Baigent, C, Blackwell, L, Collins, R, Emberson, J, Godwin, J, Peto, R, Buring, J, Hennekens, C, Kearney, P, Meade, T, Patrono, Carlo, Roncaglioni, Mc, and Zanchetti, A.
Abstract: BACKGROUND: Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention. METHODS: We undertook meta-analyses of serious vascular events (myocardial infarction, stroke, or vascular death) and major bleeds in six primary prevention trials (95,000 individuals at low average risk, 660,000 person-years, 3554 serious vascular events) and 16 secondary prevention trials (17,000 individuals at high average risk, 43,000 person-years, 3306 serious vascular events) that compared long-term aspirin versus control. We report intention-to-treat analyses of first events during the scheduled treatment period. FINDINGS: In the primary prevention trials, aspirin allocation yielded a 12% proportional reduction in serious vascular events (0.51% aspirin vs 0.57% control per year, p=0.0001), due mainly to a reduction of about a fifth in non-fatal myocardial infarction (0.18%vs 0.23% per year, p<0.0001). The net effect on stroke was not significant (0.20%vs 0.21% per year, p=0.4: haemorrhagic stroke 0.04%vs 0.03%, p=0.05; other stroke 0.16%vs 0.18% per year, p=0.08). Vascular mortality did not differ significantly (0.19%vs 0.19% per year, p=0.7). Aspirin allocation increased major gastrointestinal and extracranial bleeds (0.10%vs 0.07% per year, p<0.0001), and the main risk factors for coronary disease were also risk factors for bleeding. In the secondary prevention trials, aspirin allocation yielded a greater absolute reduction in serious vascular events (6.7%vs 8.2% per year, p<0.0001), with a non-significant increase in haemorrhagic stroke but reductions of about a fifth in total stroke (2.08%vs 2.54% per year, p=0.002) and in coronary events (4.3%vs 5.3% per year, p<0.0001). In both primary and secondary prevention trials, the proportional reductions in the aggregate of all serious vascular events seemed similar for men and women. INTERPRETATION: In primary preventi
Published: 2009

191. Assessing Cognitive Function in Rheumatoid Arthritis: Comment on the Article by Shin et al

Author: Meade, T., primary and Manolios, N., additional
Published: 2013
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192. CONSORT statement on the reporting standards in clinical trials. Recommendations are inappropriate for trial reports

Author: Meade, T, Wald, N, and Collins, R
Subjects: Letter
Published: 1997

193. Optimization of Pulsed-DEER Measurements for Gd-Based Labels: Choice of Operational Frequencies, Pulse Durations and Positions, and Temperature

Author: Raitsimring, A., primary, Astashkin, A. V., additional, Enemark, J. H., additional, Kaminker, I., additional, Goldfarb, D., additional, Walter, E. D., additional, Song, Y., additional, and Meade, T. J., additional
Published: 2012
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194. Navigating Motherhood Choices in the context of Rheumatoid Arthritis: Women's Stories

Author: Meade, T., primary, Sharpe, L., additional, Hallab, L., additional, Aspanell, D., additional, and Manolios, N., additional
Published: 2012
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195. The effect of aspirin on cancer mortality

Author: Meade, T., primary
Published: 2012
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196. Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 450,000 people in 45 prospective cohorts. Prospective studies collaboration

Author: Qizilbash, N, Lewington, S, Duffy, S, Peto, R, Smith, T, Spiegelhalter, D, Iso, H, Shimamoto, T, Komachi, Y, Iida, M, Doyle, J, Strogatz, D, Ebrahim, S, Wannamethee, G, Whincup, P, Burke, V, Cullen, K, Knuiman, M, Welborn, T, Bainton, D, Baker, I, Elwood, P, Sweetnam, P, Yarnell, J, Keil, J, Sutherland, S, Hames, C, Tyroler, H, DAgostino, R, Kannel, W, Wolf, P, Aromaa, A, Knekt, P, Maatela, J, Reunanen, A, Puska, P, Sarti, C, Tamminen, M, Tuomilehto, J, Vartiainen, E, Bengtsson, C, Bjorkelund, C, Lissner, L, Kodama, K, Shimizu, Y, Kagan, A, Popper, J, Reed, D, Yano, K, Goldbourt, U, Medalie, J, Yaari, S, Criqui, M, Davis, C, Blackburn, H, Jacobs, D, Leupker, R, Harris, T, Madans, J, Ofstedal, M, Bjartveit, K, Stensvold, I, Tverdal, A, Garrow, K, Meade, T, Ruddock, V, Haheim, L, Hjermann, I, Holme, I, Leren, P, Cambien, F, Ducimetiere, P, Richard, J, Assmann, G, BarrettConnor, E, Langer, R, Gillis, C, Hart, C, Hawthorne, V, Hole, D, Isles, C, Lever, A, Smith, GD, Aravanis, C, Buzina, R, Dontas, A, Fidanza, F, Giampaoli, S, Karvonen, M, Keys, A, Kromhout, D, Lanti, M, Menotti, A, Mohacek, I, Nedeljkovic, S, Nissinen, A, Punsar, S, Seccareccia, F, Toshima, H, Chen, Z, Collins, R, Li, W, Lu, J, Date, C, Nakayama, T, Tanaka, H, Yokoyama, T, Yoshiike, N, Brown, C, TunstallPedoe, H, Higgins, M, Keller, J, Carstensen, J, Tornberg, S, Marmot, M, and Shipley, M
Subjects: cardiovascular diseases
Abstract: Individual studies of stroke have not clearly answered two questions: on the relation, if any, between total blood cholesterol and stroke; and on how the strength of the relation between diastolic blood pressure and stroke varies with age. The associations of blood cholesterol and diastolic blood pressure with subsequent stroke rates were investigated by review of 45 prospective observational cohorts involving 450,000 individuals with 5-30 years of follow-up (mean 16 years, total 7.3 million person-years of observation), during which 13,397 participants were recorded as having had a stroke. Most of these were fatal strokes in studies that recorded only mortality and not incidence, but about one-quarter were from studies that recorded both fatal and non-fatal strokes. After standardization for age, there was no association between blood cholesterol and stroke except, perhaps, in those under 45 years of age when screened. This lack of association was not influenced by adjustment for sex, diastolic blood pressure, history of coronary disease, or ethnicity (Asian or non-Asian). However, because the types of the strokes were not centrally available, the lack of any overall relation might conceal a positive association with ischaemic stroke together with a negative association with haemorrhagic stroke. When the highest and the lowest of the six blood pressure categories were compared, the difference in usual diastolic blood pressure was 27 mm Hg (102 vs 75 mm Hg), and there was a fivefold difference in stroke risk. This fivefold difference was seen both in those with a pre-existing history of coronary heart disease and in those without it. The proportional difference in stroke risk, however, was more extreme in middle than in old age. Among those aged < 45, 45-64, and 65+ when screened, the differences in the relative risks of stroke (between the highest diastolic blood pressure category and a combination of the lowest two categories) were tenfold, fivefold, and twofold, respectively. However, because the absolute stroke risks are greater in old age, the absolute differences in the annual stroke rates showed an opposite pattern, being 2, 5, and 8 per thousand, respectively. This suggests that the effects of therapeutic blood pressure reductions should be assessed separately in middle age and in old age.
Published: 1995

197. Comparing hospital and chiropractic treatment for back pain: Authors’ reply

Author: Meade, T W, Dyer, Sandra, Browne, Wendy, and Frank, A O
Subjects: Letters
Published: 1995

198. Fetal and infant growth and cardiovascular risk factors in women

Author: Fall, C. H., Osmond, C., Barker, D. J., Clark, P. M., Hales, C. N., Stirling, Y., and Meade, T. W.
Subjects: Research Article
Abstract: OBJECTIVE--To examine whether cardiovascular risk factors in women are related to fetal and infant growth. DESIGN--Follow up study of women born 1923-30 whose birth weights and weights at one year were recorded. SETTING--Hertfordshire. SUBJECTS--297 women born and still living in East Hertfordshire. MAIN OUTCOME MEASURES--Plasma glucose and insulin concentrations during a standard oral glucose tolerance test; fasting plasma proinsulin and 32-33 split proinsulin concentrations; blood pressure; fasting serum total, low density lipoprotein and high density lipoprotein cholesterol, triglyceride, and apolipoprotein A I and B concentrations; and plasma fibrinogen and factor VII concentrations. RESULTS--Fasting plasma concentrations of glucose, insulin, and 32-33 split proinsulin fell with increasing birth weight (P = 0.04, P = 0.002, and P = 0.0002 respectively, when current body mass index was allowed for). Glucose and insulin concentrations 120 minutes after an oral glucose load showed similar trends (P = 0.03 and P = 0.02). Systolic blood pressure, waist:hip ratio, and serum triglyceride concentrations also fell with increasing birth weight (P = 0.08, P = 0.07, and P = 0.07 respectively), while serum high density lipoprotein cholesterol concentrations rose (P = 0.04). At each birth weight women who currently had a higher body mass index had higher levels of risk factors. CONCLUSION--In women, as in men, reduced fetal growth leads to insulin resistance and the associated disorders: raised blood pressure and high serum triglyceride and low serum high density lipoprotein cholesterol concentrations. The highest values of these coronary risk factors occur in people who were small at birth and became obese. In contrast with men, low rates of infant growth did not predict levels of risk factors in women.
Published: 1995

199. Recent respiratory infection and risk of venous thromboembolism: case-control study through a general practice database

Author: Clayton, T. C., primary, Gaskin, M., additional, and Meade, T. W., additional
Published: 2011
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200. Arterial Disease Risk Factors and Angiographic Evidence of Atheroma of the Carotid Artery

Author: Schneidau, A., Harrison, M. J.G., Hurst, C., Wilkes, H. C., and Meade, T. W.
Published: 1989

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