151. Outcome of intravenous immunoglobulin-transmitted hepatitis C virus infection in primary immunodeficiency
- Author
-
Maureen M. Jonas, Samiya Razvi, Charlotte Cunningham-Rundles, and Lynda C. Schneider
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Hepatitis C virus ,Hepacivirus ,medicine.medical_treatment ,Immunology ,Liver transplantation ,medicine.disease_cause ,Gastroenterology ,Antiviral Agents ,chemistry.chemical_compound ,Internal medicine ,Surveys and Questionnaires ,Ribavirin ,medicine ,Immunology and Allergy ,Humans ,Child ,Aged ,Hepatitis ,Aged, 80 and over ,biology ,business.industry ,Immunologic Deficiency Syndromes ,Immunoglobulins, Intravenous ,Interferon-alpha ,Hepatitis C ,Middle Aged ,medicine.disease ,biology.organism_classification ,Treatment Outcome ,chemistry ,Primary immunodeficiency ,Viral disease ,business ,Drug Contamination - Abstract
Physicians in the United States who treat patients with primary immunodeficiency were contacted to identify subjects who had been infected with hepatitis C due to exposure to contaminated intravenous immunoglobulin (IVIg) in 1993-1994. From this survey we gathered information on 58 PCR-positive hepatitis C-infected patients; 37 had CVID, 9 had XLA, 5 were IgG subclass deficient, 4 were antibody deficient with normal immunoglobulin levels, 2 had SCID after BMT, and 1 had B cell linker deficiency. Of the 58 subjects, 30 had been treated with IFN-alpha in combination with ribavirin in 5 cases, and 26 other subjects were not treated. Of those who were treated, 11 (37%) resolved the infection and became PCR-negative; of the 26 who were not treated, 5 (19%) have resolved the infection, outcomes not significantly different. Patients 20 years of age or younger had a significantly better outcome compared to those older than age 20 (P = 0.02). Five subjects of the 58 have had a liver transplantation, a sixth has had two transplants, and 10 (17%) of the group have died. This survey demonstrates the heterogeneity of the clinical outcome in subjects with primary immunodeficiency who contracted hepatitis C due to viral contamination of IVIg.
- Published
- 2001