432 results on '"Masson, Jean-Francois"'
Search Results
152. In-Situ AFM Studies of the Phase-Transition Behavior of Single Thermoresponsive Hydrogel Particles
- Author
-
Wiedemair, Justyna, primary, Serpe, Michael J., additional, Kim, Jongseong, additional, Masson, Jean-Francois, additional, Lyon, L. Andrew, additional, Mizaikoff, Boris, additional, and Kranz, Christine, additional
- Published
- 2006
- Full Text
- View/download PDF
153. Detection of biomolecules in complex media using surface plasmon resonance sensors
- Author
-
Malone, Michael R., primary, Masson, Jean-Francois, additional, Barhnart, Margaret, additional, Beaudoin, Stephen, additional, and Booksh, Karl S., additional
- Published
- 2005
- Full Text
- View/download PDF
154. Nondestructive Monitoring of the Photochromic State of Dithienylethene Monolayers by Surface Plasmon Resonance
- Author
-
Masson, Jean-Francois, primary, Liddell, Paul A., additional, Banerji, Soame, additional, Battaglia, Tina M., additional, Gust, Devens, additional, and Booksh, Karl S., additional
- Published
- 2005
- Full Text
- View/download PDF
155. Fiber-optic surface plasmon resonance for vapor phase analyses
- Author
-
Kim, Yoon-Chang, primary, Banerji, Soame, additional, Masson, Jean-Francois, additional, Peng, Wei, additional, and Booksh, Karl S., additional
- Published
- 2005
- Full Text
- View/download PDF
156. Surface plasmon resonance sensors for industrial applications
- Author
-
Masson, Jean-Francois, primary, Banerji, Soame, additional, Kim, Yoon-Chang, additional, and Booksh, Karl S., additional
- Published
- 2004
- Full Text
- View/download PDF
157. Applications of small surface plasmon resonance sensors for biochemical monitoring
- Author
-
Masson, Jean-Francois, primary, Battaglia, Tina M., additional, Beaudoin, Stephen, additional, and Booksh, Karl S., additional
- Published
- 2004
- Full Text
- View/download PDF
158. Preparation of analyte-sensitive polymeric supports for biochemical sensors
- Author
-
Masson, Jean-Francois, primary, Battaglia, Tina M., additional, Kim, Yoon-Chang, additional, Prakash, Anna, additional, Beaudoin, Stephen, additional, and Booksh, Karl S., additional
- Published
- 2004
- Full Text
- View/download PDF
159. In vitro biochemical monitoring with fiber-optic-based surface plasmon resonance sensors
- Author
-
Masson, Jean-Francois, primary, Hamersky, Kayla, additional, Beaudoin, Stephen, additional, and Booksh, Karl S., additional
- Published
- 2004
- Full Text
- View/download PDF
160. Fiber-optic-based surface plasmon resonance (SPR) sensors for the detection of toxic nerve agents
- Author
-
Prakash, Anna M. C., primary, Kim, Yoon-Chang, additional, Banerji, Soame, additional, Masson, Jean-Francois, additional, and Booksh, Karl S., additional
- Published
- 2004
- Full Text
- View/download PDF
161. Monitoring of recombinant survival motor neuron protein using fiber-optic surface plasmon resonance
- Author
-
Masson, Jean-Francois, primary, Barnhart, Margaret, additional, Battaglia, Tina M., additional, Morris, Glenn E., additional, Nieman, Ronald A., additional, Young, Philip J., additional, Lorson, Christian L., additional, and Booksh, Karl S., additional
- Published
- 2004
- Full Text
- View/download PDF
162. Optical properties of gold particles with near micron size: localized and propagating surface plasmons.
- Author
-
Live, Ludovic S. and Masson, Jean-Francois
- Published
- 2009
- Full Text
- View/download PDF
163. Surface plasmon resonance sensors for detection of survival of motor neuron protein.
- Author
-
Mitropanopoulos, Margaret, Campanaro, Becki, Malone, Michael, Masson, Jean-Francois, Nieman, Ronald A., Lorson, Christian L., and Booksh, Karl S.
- Published
- 2006
- Full Text
- View/download PDF
164. Viscoelastic Modeling of Straight Run and Modified Binders Using the Matching Function Approach
- Author
-
Elseifi, Mostafa A., primary, Al-Qadi, Imad L., additional, Flinstch, Gerardo W., additional, and Masson, Jean-Francois, additional
- Published
- 2002
- Full Text
- View/download PDF
165. Novel surface coatings for antibody attachment to surface plasmon resonance sensors.
- Author
-
Malone, Michael R., Masson, Jean-Francois, Beaudoin, Stephen, and Booksh, Karl S.
- Published
- 2005
- Full Text
- View/download PDF
166. Tuning the 3D plasmon field of nanohole arrays.
- Author
-
Couture, Maxime, Liang, Yuzhang, Poirier Richard, Hugo-Pierre, Faid, Rita, Peng, Wei, and Masson, Jean-Francois
- Published
- 2013
- Full Text
- View/download PDF
167. Solid-state NMR of some cellulose/synthetic polymer blends
- Author
-
Masson, Jean Francois, primary and Manley, R. St. John, additional
- Published
- 1992
- Full Text
- View/download PDF
168. Miscible blends of cellulose and poly(vinylpyrrolidone)
- Author
-
Masson, Jean Francois, primary and Manley, R. St. John, additional
- Published
- 1991
- Full Text
- View/download PDF
169. Cellulose/poly(4-vinylpyridine) blends
- Author
-
Masson, Jean Francois, primary and Manley, R. St. John, additional
- Published
- 1991
- Full Text
- View/download PDF
170. Bitumen morphologies by phase-detection atomic force microscopy.
- Author
-
MASSON, JEAN-FRANCOIS, LEBLOND, V., and MARGESON, J.
- Subjects
- *
BITUMEN , *NONMETALLIC minerals , *HYDROCARBONS , *MICROSTRUCTURE , *ATOMIC force microscopy - Abstract
Bitumen is a complex mixture of hydrocarbons for which microstructural knowledge is incomplete. In an effort to detail this microstructure, 13 bitumens were analysed by phase-detection atomic force microscopy. Based on morphology, the bitumens could be classified into three distinct groups. One group showed fine domains down to 0.1 µm, another showed domains of about 1 µm, and a third group showed up to four different domains or phases of different sizes and shapes. No correlation was found between the atomic force microscopy morphology and the composition based on asphaltenes, polar aromatics, naphthene aromatics and saturates. A high correlation was found between the area of the ‘bee-like’ structures and the vanadium and nickel content in bitumen, and between the atomic force microscopy groups and the average size of molecular planes made of fused aromatics. The morphology and the molecular arrangements in bitumen thus appear to be partly governed by the molecular planes and the polarity defined by metallic cations. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
171. Single-crystal sapphire-fiber optic sensors based on surface plasmon resonance spectroscopy for in situ monitoring
- Author
-
Kim, Yoon-Chang, Masson, Jean-Francois, and Booksh, Karl S.
- Subjects
- *
FIBER optics , *DETECTORS , *RAPID thermal processing , *SILICON compounds - Abstract
Abstract: Single-crystal sapphire-fiber optic sensors based on surface plasmon resonance (SPR) for refractive index (RI) measurements of aqueous and hydrothermal water solutions are described. Accurate measurement of RIs is essential to efficient operation and control of broad range of engineering processes. Some of these processes are carried out with harsh environments, such as high-temperature, high pressure, and chemical corrosion. These extreme physical conditions are proving a limiting factor in application of the conventional silica-based optical sensors. Single-crystal sapphire is an ideal material for sensor applications, where reliable performance is required in the extreme environment conditions. With regard to the liquid species detection, most applications of SPR sensors are designed to function near the refractive index of water (1.3330RI). The RI changes of aqueous solution can be easily monitored by silica-fiber (RI, 1.4601 at 550nm) based SPR sensor. However, the sapphire waveguide has a prohibitively high RI (1.7708 at 546nm) for unmodified monitoring of the RI changes of aqueous solutions. For that purpose, a practical SPR probe geometry has been applied to the ability to tune the SPR coupling wavelength/angle pair with sapphire-fiber based SPR probe. [Copyright &y& Elsevier]
- Published
- 2005
- Full Text
- View/download PDF
172. Biocompatible polymers for antibody support on gold surfaces
- Author
-
Masson, Jean-Francois, Battaglia, Tina M., Davidson, Michael J., Kim, Yoon-Chang, Prakash, Anna M.C., Beaudoin, Stephen, and Booksh, Karl S.
- Subjects
- *
CARBOHYDRATES , *POLYMERS , *MACROMOLECULES , *SURFACE chemistry , *DETECTORS , *COATING processes - Abstract
Abstract: The elimination or minimization of non-specific protein adsorption from serum is critical for the use of surface plasmon resonance (SPR) sensors for in vitro and in vivo analysis of complex biological solutions. The ultimate goals in this application are to minimize non-specific adsorption of protein and to maximize analyte signal. A reduction of the non-specific protein adsorption from serum of up to 73% compared to carboxymethylated-dextran 500kDa (CM-dextran) was achieved following a survey of eight biocompatible polymers and 10 molecular weights of CM-dextran. These coatings minimize non-specific adsorption on the sensor while also serving as immobilization matrices for antibody fixation to the probes. Polymers including polysaccharides: CM-dextrans, CM-hyaluronic acid, hyaluronic acid, and alginic acid were investigated. Humic acid, polylactic acid, polyacrylic acid, orthopyridyldisuldfide–polyethyleneglycol–N-hydroxysuccinimide (OPSS–PEG–NHS), and a synthesized polymer; polymethacrylic-acid-co-vinyl-acetate (PMAVA) were also used. The non-specific protein adsorption reduction was measured over a 14 day period at 0°C for each polymer. Calibration curves using some of these polymers were constructed to show the performance and low detection limit possibilities of these new antibody supports. For many of the polymers, this is the first demonstration of employment as an antibody support for an optical or surface active sensor. CM-dextran is the polymer offering the largest signal for the antigen detection. However, the biocompatible polymers demonstrate a greater stability to non-specific binding in serum. These biocompatible polymers offer different alternatives for CM-dextran. [Copyright &y& Elsevier]
- Published
- 2005
- Full Text
- View/download PDF
173. Localized and Propagating Surface Plasmons in Gold Particles of Near-Micron Size
- Author
-
Live, Ludovic S., Murray-Méthot, Marie-Pier, and Masson, Jean-Francois
- Abstract
In this letter, we demonstrate that Au triangles between approximately 200 nm and 1.5 μm are transitioning from a predominantly localized surface plasmon resonance (LSPR) character to a regime where both LSPR and a short-range SPR mode are concomitantly present. The Au triangles are active in LSPR between approximately λ = 700 nm for the smaller triangles and λ = 2.5 μm for the largest Au triangles. Triangles with a base length of 200 and 300 nm do not exhibit an active short-range SPR mode, while triangles with 500 and 700 nm and 1.5 μm base lengths show a strong absorption peak in SPR at approximately λ = 800 nm, attributed to the short-range SPR mode. A low sensitivity of <50 nm/RIU is observed with this short-range SPR mode in triangles of near-micron size. Also, Au nanohole arrays exhibit features in both the submicron size, with gold “island” between neighboring nanoholes, and on the order of tens of microns, with gold “strips” along rows of nanoholes. The excitation of nanohole arrays in total internal reflection (TIR) results in the presence of both a short-range SPR mode similar to that of gold triangles and a propagating SPR mode similar to that of a thin Au film of macroscopic surface. For Au nanohole arrays of 820 nm periodicity, TIR experiments result in two overlapping absorption peaks at λ = 650 and 800 nm, corresponding respectively to propagating SPR in thin films (typically around λ = 615 nm) and the short-range SPR mode in Au triangles.
- Published
- 2009
- Full Text
- View/download PDF
174. Drug-Based Gold Nanoparticles Overgrowth for Enhanced SPR Biosensing of Doxycycline.
- Author
-
Kazmi, Syed Akif Raza, Qureshi, Muhammad Zahid, and Masson, Jean-Francois
- Subjects
DOXYCYCLINE ,DRUG monitoring ,TREATMENT effectiveness ,SURFACE plasmon resonance ,BIOSENSORS ,COLLOIDAL stability ,YIELD surfaces ,GOLD nanoparticles - Abstract
In clinical chemistry, frequent monitoring of drug levels in patients has gained considerable importance because of the benefits of drug monitoring on human health, such as the avoidance of high risk of over dosage or increased therapeutic efficacy. In this work, we demonstrate that the drug doxycycline can act as an Au nanoparticle (doxy-AuNP) growth and capping agent to enhance the response of a surface plasmon resonance (SPR) biosensor for this drug. SPR analysis revealed the high sensitivity of doxy-AuNPs towards the detection of free doxycycline. More specifically, doxy-AuNPs bound with protease-activated receptor-1 (PAR-1) immobilized on the SPR sensing surface yield the response in SPR, which was enhanced following the addition of free doxy (analyte) to the solution of doxy-AuNPs. This biosensor allowed for doxycycline detection at concentrations as low as 7 pM. The study also examined the role of colloidal stability and growth of doxy-AuNPs in relation to the response-enhancement strategy based on doxy-AuNPs. Thus, the doxy-AuNPs-based SPR biosensor is an excellent platform for the detection of doxycycline and demonstrates a new biosensing scheme where the analyte can provide enhancement. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
175. Combining multilayered wrinkled polymer SERS substrates and spectral data processing for low concentration analyte detection.
- Author
-
Charron, Benjamin, Thibault, Vincent, and Masson, Jean-Francois
- Subjects
- *
SERS spectroscopy , *POLYMERS , *GOLD nanoparticles , *RAMAN spectroscopy , *SINGLE molecules , *ELECTRONIC data processing , *DYNAMIC testing - Abstract
A series of thermally shrinkable polymer surface-enhanced Raman scattering (SERS) substrates were prepared with bimetallic Au and Ag (oxidized or not) films and with Au nanoparticles (AuNPs) located at different places in the layered structure to evaluate the synergistic effect of different known SERS amplification methods to enhance the Raman signal for low concentration dopamine detection. A bimetallic Au and Ag layered structure improved the Raman signal by 5 and 2 times compared to the single-layered Au and Ag films. Oxidizing the Ag layer prior to deposition of Au further improved the signal by a factor of 2, while adding AuNP on wrinkled films increased another 10 times the intensity of the Raman signal. It was found that the enhancement was another 10 times stronger when using AuNPs in combination with other means of enhancement such as with a silver underlayer or surface wrinkling. Wrinkling alone only gave a few-fold increase compared to a flat film, but the combination of wrinkling with AuNPs and a silver underlayer improved the SERS intensity by more than 3 orders of magnitude, showing the synergistic effect of these enhancement methods. The optimized sensors were then tested in dynamic SERS with low concentration dopamine solutions, where the signal showed characteristics of a digital SERS response. Raman spectra preprocessing and sorting software was developed to triage the SERS-active spectra from the null spectra, to count the detection events such as the ones observed in single molecule experiments. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
176. Correlated AFM and SERS imaging of the transition from nanotriangle to nanohole arraysElectronic supplementary information (ESI) available: Experimental procedure; Raman images. See DOI: 10.1039/c0cc05287fThis article is part of a ChemComm web-based themed issue on Surface Enhanced Raman Spectroscopy.
- Author
-
GibsonThese authors have contributed equally to this manuscript., Kirsty F., Correia-Ledo, Debby, Couture, Maxime, Graham, Duncan, and Masson, Jean-Francois
- Subjects
NANOSTRUCTURES ,COLLOIDAL silver ,ATOMIC force microscopy ,SURFACE enhanced Raman effect ,CHEMISTRY experiments ,STATISTICAL correlation - Abstract
Mapping the transition of Ag nanotriangle to nanohole arrays revealed that the optimal SERS response was obtained near the transition. Correlated AFM and Raman imaging provided novel experimental proof that hot spots are located on Ag islands for nanotriangle arrays and in the core area of the hole for nanohole arrays, which is in agreement with previous theoretical predictions. [ABSTRACT FROM AUTHOR]
- Published
- 2011
177. Multiplexed SERS Detection of Microcystins with Aptamer-Driven Core–Satellite Assemblies
- Author
-
Luo, Xiaojun, Zhao, Xingjuan, Wallace, Gregory Q., Brunet, Marie-Hélène, Wilkinson, Kevin J., Wu, Ping, Cai, Chenxin, Bazuin, C. Geraldine, and Masson, Jean-Francois
- Abstract
We describe surface-enhanced Raman spectroscopy (SERS) aptasensors that can indirectly detect MC-LR and MC-RR, individually or simultaneously, in natural water and in algal culture. The sensor is constructed from nanoparticles composed of successive layers of Au core–SERS label–silver shell–gold shell (Au@label@Ag@Au NPs), functionalized on the outer Au surface by MC-LR and/or MC-RR aptamers. These NPs are immobilized on asymmetric Au nanoflowers (AuNFs) dispersed on planar silicon substrates through DNA hybridization of the aptamers and capture DNA sequences with which the AuNFs are functionalized, thereby forming core–satellite nanostructures on the substrates. This construction led to greater electromagnetic (EM) field enhancement of the Raman label-modified region, as supported by finite-difference time-domain (FDTD) simulations of the core–satellite assembly. In the presence of MC-LR and/or MC-RR, the aptamer-functionalized NPs dissociate from the AuNFs because of the stronger affinity of the aptamers with the MCs, which decreases the SERS signal, thus allowing indirect detection of the MCs. The improved SERS sensitivity significantly decreased the limit of detection (LOD) for separate MC-LR detection (0.8 pM) and for multiplex detection (1.5 pM for MC-LR and 1.3 pM for MC-RR), compared with other recently reported SERS-based methods for MC-LR detection. The aptasensors show excellent selectivity to MC-LR/MC-RR and excellent recoveries (96–105%). The use of these SERS aptasensors to monitor MC-LR production over 1 week in a culture medium of M. aeruginosacells demonstrates the applicability of the sensors in a realistic environment.
- Published
- 2021
- Full Text
- View/download PDF
178. Fabricating SERS-Active Nanofibers Covered with Au Nanoparticles for SERS Optophysiology.
- Author
-
Xingjuan Zhao, Wallace, Gregory Q., Bazuin, C. Geraldine, and Masson, Jean-Francois
- Published
- 2021
- Full Text
- View/download PDF
179. (Invited) Plasmonic and Surface Plasmon Electrochemiluminescence Sensors for Detecting Biomarkers and Drugs.
- Author
-
Masson, Jean-Francois and Polo, Federico
- Published
- 2021
- Full Text
- View/download PDF
180. Rapid Quantification of Sars-Cov-2 Antibodies with a Portable Surface Plasmon Resonance Biosensor.
- Author
-
Jodaylami, Maryam Hojjat, Djaileb, Abdelhadi, Live, Ludovic S., Boudreau, Denis, Pelletier, Joelle, and Masson, Jean-Francois
- Published
- 2021
- Full Text
- View/download PDF
181. Characterization of low temperature mechanical properties of crack sealants utilizing direct tension test.
- Author
-
National Research Council Canada, Virginia. Dept. of Transportation, Illinois Center for Transportation, United States. Federal Highway Administration, Al-Qadi, Imad L., Yang, Shih-Hsien, Masson, Jean-Francois, McGhee, Kevin K., University of Illinois at Urbana-Champaign. Department of Civil and Environmental Engineering, National Research Council Canada, Virginia. Dept. of Transportation, Illinois Center for Transportation, United States. Federal Highway Administration, Al-Qadi, Imad L., Yang, Shih-Hsien, Masson, Jean-Francois, McGhee, Kevin K., and University of Illinois at Urbana-Champaign. Department of Civil and Environmental Engineering
- Abstract
VTRC Project # 67775, TPF-5(045), Crack sealing has been widely used as a routine preventative maintenance practice. Given its proper, installation, crack sealants can extend pavement service life by three to five years. However, current, specifications for the selection of crack sealants correlate poorly with field performance. The purpose of this, research was to develop performance guidelines for the selection of hot-poured bituminous crack sealants at, low temperature. This was accomplished by measuring the mechanical properties of crack sealant at low, temperature and then developing performance criteria for material selection. The modified direct tension test, (DTT), crack sealant direct tension test (CSDTT), simulates the in-situ loading behavior of crack sealants in the, laboratory. A modified dog-bone specimen geometry, which allows specimens to be stretched up to 95%, is, recommended. This new specimen geometry also facilitates sample preparation. Tensile force is applied to the, dog-bone specimen, with its effective gauge length of 20.3mm, and is pulled at a deformation rate of, 1.2mm/min. Fifteen sealants were tested at various temperatures, and three performance parameters are, suggested as indicators of sealant performance: extendibility, percent modulus reduction, and strain energy, density. Extendibility, which is used to assess the degree of deformation undergone by a sealant at low, temperature before it ruptures or internal damage is observed, is recommended as a measured parameter to be, included in the performance-based guidelines for the selection of hot-poured crack sealants. Extendibility, thresholds were defined as function of low service temperatures. The CSDT is conducted at +6oC above the, lowest in service temperature because of the relatively high test loading rate compared to in-situ crack sealant, movement rate.
182. Characterization of low temperature creep properties of crack sealants using bending beam rehometry.
- Author
-
Louisiana State University (Baton Rouge, La.), University of Texas at San Antonio, Reseau National Universitaire, Tunisia, National Research Council Canada, Virginia Transportation Research Council (VTRC), Virginia. Dept. of Transportation, United States. Federal Highway Administration, Al-Qadi, Imad L., Yang, Shih-Hsien, Elseifi, Mostafa A., Dessouky, Samer, Loulizi, Amara, Masson, Jean-Francois, McGhee, Kevin K., University of Illinois at Urbana-Champaign. Department of Civil and Environmental Engineering, Louisiana State University (Baton Rouge, La.), University of Texas at San Antonio, Reseau National Universitaire, Tunisia, National Research Council Canada, Virginia Transportation Research Council (VTRC), Virginia. Dept. of Transportation, United States. Federal Highway Administration, Al-Qadi, Imad L., Yang, Shih-Hsien, Elseifi, Mostafa A., Dessouky, Samer, Loulizi, Amara, Masson, Jean-Francois, McGhee, Kevin K., and University of Illinois at Urbana-Champaign. Department of Civil and Environmental Engineering
- Abstract
VTRC Project # 67775, TPF-5(045), Crack sealing has been widely used as a routine preventative maintenance practice. Given its proper installation, crack sealants can extend, pavement service life by three to five years. However, current specifications for the selection of crack sealants correlate poorly with field, performance. The purpose of this research was to develop performance guidelines for the selection of hot-poured bituminous crack sealants at, low temperature. In this part of the research, the creep behavior of crack sealant at low temperature is measured and performance criteria for, material selection were developed. Because various pavement and State agencies are well acquainted with and own the Bending Beam, Rheometer (BBR), which was developed during the Strategic Highway Research Program (SHRP), an attempt was made to utilize the same, setup to test hot-poured bituminous-based crack sealants. Testing conducted in this research project indicated that the standard BBR was, inappropriate for testing soft bituminous-based hot-poured crack sealant, even at -40°C. The measured deflection exceeded the BBR limit, for, some sealants, after only a few seconds of loading. To address this issue, the moment of inertia of the tested beam was increased by doubling, its thickness (from 6.35mm to 12.7mm). For the new beam dimensions, it was found that only 4% of the beam center deflection is due to shear, a, value deemed acceptable for sealant evaluation and comparison., In an effort towards developing a robust testing procedure, 15 sealants from various manufacturers were included in the study and tested, between –4°C and –40°C. In addition, five sealants, which have known field performance, were tested to validate the laboratory results and, establish specification thresholds for the selection guidelines. Since stiffness calculation in the BBR test method requires that measurements be, made within the linear region of viscoelastic behavior, validation of this theory was conducted for crack sealants. This was found to be generally, the case with crack sealants, which allowed for the use of the time-temperature superposition. If the temperature-superposition principle is, applied, the stiffness at 240s at a given temperature can be used to predict the stiffness after 5hr of loading at a temperature that is 6°C lower., With the assumption of linear viscoelastic behavior, sealants performance can be characterized through stiffness, average creep rate, and, dissipated energy ratio. Stiffness was found to be sensitive to temperature changes and could be used to differentiate between sealants. The, measurements of the average creep rate and the dissipated energy ratio were also found to be valuable in differentiating between sealants. In, addition, numerical modeling was used to simulate the mechanical response of crack sealants at low temperatures. Parameters that may be, used for evaluating crack sealant cohesive performance using the crack sealant BBR (CSBBR) are the stiffness at 240s, average creep rate, and, the dissipated energy ratio. For simplicity, the first two parameters, stiffness at 240s and average creep rate, are recommended for, implementation in the sealant performance grade. The recommended thresholds are maximum stiffness of 25MPa and minimum average creep, rate of 0.31.
183. Development of apparent viscosity test for hot-poured crack sealants.
- Author
-
National Research Council Canada, Reseau National Universitaire, Tunisia, Virginia. Dept. of Transportation, Louisiana State University (Baton Rouge, La.), Illinois Center for Transportation, United States. Federal Highway Administration, Al-Qadi, Imad L., Fini, Eli H., Masson, Jean-Francois, Loulizi, Amara, McGhee, Kevin K., Elseifi, Mostafa A., University of Illinois at Urbana-Champaign. Department of Civil and Environmental Engineering, National Research Council Canada, Reseau National Universitaire, Tunisia, Virginia. Dept. of Transportation, Louisiana State University (Baton Rouge, La.), Illinois Center for Transportation, United States. Federal Highway Administration, Al-Qadi, Imad L., Fini, Eli H., Masson, Jean-Francois, Loulizi, Amara, McGhee, Kevin K., Elseifi, Mostafa A., and University of Illinois at Urbana-Champaign. Department of Civil and Environmental Engineering
- Abstract
VTRC Project # 67775, TPF-5(045), Current crack sealant specifications focuses on utilizing simple empirical tests such as penetration, resilience, flow, and bonding to cement concrete briquettes (ASTM D3405) to measure the ability of the material, to resist cohesive and adhesion failures. There is, however, no indication of the pertinence of these standard, tests to predict the success of field installation and sealant performance. In an effort to bridge the gap between, sealant fundamental properties and field performance, performance-based guidelines for selection of hot-poured, crack sealants are currently being developed. This report focuses on the development of the apparent viscosity, test method. This test uses a modified version of the Brookfield rotational viscometer. Based on the results of, this study, the measured apparent viscosity of hot-poured crack sealant using SC4-27 spindle at 60rpm (20.4s-1), at the recommended installation temperature was determined to be reasonably representative of sealant, viscosity at shear rates resembling field application. To ensure measurement consistency and stability, a 20min, melting time and a 30-s waiting time prior to data collection are recommended. To establish precision and bias, for the test, a round robin testing was conducted among seven laboratories. Average coefficient of variation, within and between laboratories was found to be 2% and 6%, respectively. Using the data from the round robin, testing, and based on ASTM precision and bias standard (ASTM practices C802 and C670), maximum, permissible differences within a laboratory and between laboratories were found to be 4.6% and 16.9%., Considering the high polymer or crumb rubber content in crack sealants and sealant temperature sensitivity, the, repeatability and reproducibility of the developed test is within an acceptable range. These values are, comparable to those of asphalt binder: 3.5% and 14.5% based on ASTM D4402-02 and 3.5% and 12.1% based, on AASHTO 2006 T316.
184. Development of performance-based guidelines for selection of bituminous-based hot-poured pavement crack sealant : an executive summary report.
- Author
-
Al-Qadi, Imad L, Masson, Jean-Francois, Yang, Shih-Hsien, Fini, Eli, McGhee, Kevin K, Virginia Transportation Research Council (VTRC), Virginia. Dept. of Transportation, United States. Federal Highway Administration, Al-Qadi, Imad L, Masson, Jean-Francois, Yang, Shih-Hsien, Fini, Eli, McGhee, Kevin K, Virginia Transportation Research Council (VTRC), Virginia. Dept. of Transportation, and United States. Federal Highway Administration
- Abstract
This report summarizes research presented in separate technical reports, papers, and journal articles that collectively document the development of a systematic process to aid in the selection of appropriate bituminous hot-poured sealants for pavement cracks and joints. The following process elements are summarized herein: Apparent Viscosity Test for Hot-Poured Crack Sealants, Development of a Short-Term Aging Test and Low-Temperature Testing Bibliography, Sealant Flow and Deformation by Dynamic Shear Rheometry in Summer Temperatures, Characterization of Low Temperature Creep Properties of Crack Sealants Using Crack Sealant Bending Beam Rheometry, Characterization of Low Temperature Mechanical Properties of Crack Sealants Using Crack Sealant Direct Tension Test, and Development of Adhesion Tests for Crack Sealants at Low Temperature. This report brings the results of this cumulative research together to introduce a set of tests and performance parameters for sealant at installation and service temperatures; an aging procedure to simulate sealant weathering; and most important, a simplified chart with thresholds for all performance parameters for the straightforward selection of crack sealant.
185. Adhesion testing procedure for hot-poured crack sealants.
- Author
-
United States. Federal Highway Administration, Virginia. Dept. of Transportation, Al-Qadi, Imad L., Fini, Eli H., Figueroa, Hector D., Masson, Jean-Francois Masson, McGhee, Kevin K., University of Illinois at Urbana-Champaign. Department of Civil and Environmental Engineering, Quality Engineering Solutions, Inc., National Research Council Canada, Virginia Transportation Research Council (VTRC), United States. Federal Highway Administration, Virginia. Dept. of Transportation, Al-Qadi, Imad L., Fini, Eli H., Figueroa, Hector D., Masson, Jean-Francois Masson, McGhee, Kevin K., University of Illinois at Urbana-Champaign. Department of Civil and Environmental Engineering, Quality Engineering Solutions, Inc., National Research Council Canada, and Virginia Transportation Research Council (VTRC)
- Abstract
VTRC Project # 67775, TPF-5(045), Crack sealing is a common pavement maintenance treatment because it extends pavement service life significantly., However, crack sealant often fails prematurely due to a loss of adhesion. Because current test methods are mostly, empirical and only provide a qualitative measure of bond strength, they cannot predict sealant adhesive failure accurately., Hence, there is an urgent need for test methods based on bituminous sealant rheology that can better predict sealant field, performance. This study introduces three laboratory tests aimed to assess the bond property of hot-poured crack sealant to, pavement crack walls. The three tests are designed to serve the respective needs of producers, engineers, and, researchers. The first test implements the principle of surface energy to measure the thermodynamic work of adhesion, which is the energy spent in separating the two materials at the interface. The work of adhesion is reported as a measure of, material compatibility at an interface. The second test is a direct adhesion test, a mechanical test which is designed to, closely resemble both the installation process and the crack expansion due to thermal loading. This test uses the Direct, Tensile Test (DTT) machine. The principle of the test is to apply a tensile force to detach the sealant from its aggregate, counterpart. The maximum load, Pmax, and the energy to separation, E, are calculated and reported to indicate interface, bonding. The third test implements the principles of fracture mechanics in a pressurized circular blister test. The apparatus, is specifically designed to conduct the test for bituminous crack sealant, asphalt binder, or other bitumen-based materials., In this test, a fluid is injected at a constant rate at the interface between the substrate (aggregate or a standard material), and the adhesive (crack sealant) to create a blister. The fluid pressure and blister height are measured as functions of time, the data is used to calculate Interfacial Fracture Energy (IFE), which is a fundamental property that can be used to predict, adhesion. The stable interface debonding process makes this test attractive. This test may also provide a means to quantify, other factors, such as the moisture susceptibility of a bond. In addition, the elastic modulus of the sealant and its residual, stresses can be determined analytically. While the direct adhesion test is proposed as part of a newly developed, performance-based guideline for the selection of hot-poured crack sealant, the blister test can be used to estimate the, optimum annealing time and installation temperature.
186. Influence of bovine and human serum albumin on the binding kinetics of biomolecular interactions.
- Author
-
Charron, Benjamin, Delorme, Alexandre, Dubois, Caroline, Hojjat Jodaylami, Maryam, and Masson, Jean-Francois
- Subjects
- *
SERUM albumin , *SURFACE plasmon resonance , *EXTRACELLULAR matrix proteins , *BINDING site assay , *BOS , *BINDING constant - Abstract
Bovine serum albumin (BSA) containing buffers are the standard blocking buffer in biosensing, yet human serum is the intended application for most clinical sensors. However, the effect of human serum albumin (HSA) on binding assays remains underexplored. A simple and well-studied assay (human IgG/goat anti-human IgG) was investigated with a surface plasmon resonance (SPR) sensor to address this fundamental question in sensing. Calibrations were performed with buffers containing various concentrations of bovine or human serum albumin, as well as full and diluted bovine or IgG-depleted human serum. It was found that HSA or human serum, but not BSA or bovine serum, significantly affected the SPR shift and binding constants of the assay. Interestingly, large differences were also observed depending on whether the animal or human antibody was immobilized on the SPR chip for detection, highlighting that matrix protein/analyte/receptor interactions play a significant role in the response. We find that the interaction of soluble HSA with human IgG interferes with the recognition region, affecting the binding constant, and thus results obtained in BSA are not necessarily applicable to clinical samples or in vivo conditions. We also clearly demonstrate why a minimum dilution of 1 : 10 is often required in SPR assays to remove most background effects. Taken together, these results show that: (1) BSA does not affect the binding constant between antibodies and thus serves its purpose well when only surface blocking is intended, (2) HSA is an adequate surrogate for human serum in assay optimization, and (3) blocking buffers should be prepared with HSA in the optimization steps of assays to be translated to human blood or serum. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
187. Maturation of ATP Stimulus-Response at Rat Carotid Bodies Using Amperometric Microbiosensors.
- Author
-
Masson, Jean-Francois, Kranz, Christine, Mizaikoff, Boris, and Gauda, Estelle
- Subjects
- *
ADENOSINE triphosphate , *CONDITIONED response , *CAROTID body , *BIOSENSORS , *CONDUCTOMETRIC analysis , *LABORATORY rats - Abstract
ATP mediates chemoexcitation via binding to P2X2-P2X3 receptors. We developed amperometric ATP microbiosensors to determine the role of ATP in mediating maturation of chemosensitivity of peripheral arterial chemoreceptors at the carotid body (CB) to physiological stimuli. ATP is detected by immobilizing glucose oxidase and hexokinase within a polymer matrix at the surface of a 25 µm-diameter Pt disk electrode. The age-dependent ATP release from CBs was measured in real-time in response to hypoxia ([O2] < 1 ppm), and to normoxic hypercapnia (10-12% CO2). During hypoxia, ATP released at the CB was 4.3 ± 0.3 µM (median = 4.2 µM, n = 9) in rats between 3-6 postnatal days (PNDs), which increased to 91 ± 28 µM ATP (median = 19 µM, n = 6) at CBs of rats between 16-20 PNDs. The significant difference in ATP release from CBs of older animals suggests that hypoxic ATP release mechanisms are maturating during the 3rd week of postnatal development. However, in response to hypercapnia ATP release was only 6.1 ± 0.9 µM (median = 4.9 µM, n = 7) during the 3rd week, indicating that the development of hypercapnic ATP release mechanisms is different from hypoxia in rats. The 5-fold increase in ATP release in response to hypoxia during the first 3 weeks of postnatal development may contribute to the increase in hypoxic chemosensitivity, which occurs during early postnatal development. [ABSTRACT FROM AUTHOR]
- Published
- 2007
188. Biosensors based on the plasmonic properties of Au microhole arrays
- Author
-
Live, Ludovic S., Breault-Turcot, Julien, Bolduc, Olivier, and Masson, Jean-Francois
- Abstract
The plasmonic properties of metallic nanoparticles and macroscopic Au film have been thoroughly investigated for the development of biosensors based on surface plasmon resonance (SPR). Nanoparticle based localized surface plasmon resonance (LSPR) is a technique extremely sensitive to molecular adsorbate, whilst conventional SPR based on the Kretschmann configuration (macroscopic smooth Au film) is especially sensitive to bulk refractive index. SPR currently provides the best RI resolution, a measure typically used for comparison of the potential of plasmonic sensor. A technique that could combine high bulk refractive index resolution and high sensitivity to molecular adsorbate would increase the scope of SPR-based technique by providing lower detection limits. A potential solution may exploit micro-structured Au films. However, the plasmonic properties of micropatterned metallic films are still relatively unknown. We have undertaken the study of the plasmonic properties from Au film with features on the order of 1 to 3 m. Microtriangle and microhole arrays were fabricated by modified nanosphere lithography, consisting of a polymer microsphere mask deposited in a close-packed hexagonal monolayer, etched by oxygen plasma. Etch time controls the diameter of the microhole and the initial microsphere diameter sets the periodicity. Investigation of the SPR properties in the Kretschmann configuration was undertaken using a SPR with a dove prism and a multi-wavelength scanning angle SPR. The sensitivity of SPR with microhole arrays exhibits an improvement by a factor of 3 in comparison to SPR using a smooth Au film. This is accomplished by tuning the angle to near 73 degrees (with a BK7 glass prism). Moreover, the sensitivity to the immobilization of an antibody was improved by at least a factor of 4 as demonstrated with the kinetics of immobilization for IgY, without employing secondary amplification techniques. No modification to the instrumentation is required and microhole arrays improve resolution of the SPR response.
- Published
- 2011
- Full Text
- View/download PDF
189. Propagating Surface Plasmon Resonance on Microhole Arrays.
- Author
-
Live, Ludovic S., Bolduc, Olivier R., and Masson, Jean-Francois
- Subjects
- *
SURFACE plasmon resonance , *PLASMONS (Physics) , *THIN films , *OPTICAL properties , *NANOPARTICLES , *REFRACTIVE index - Abstract
Metallic thin films patterned with micrometer size triangle or hole arrays present plasmonic properties when excited in the Kretschmann configuration, that are improved in comparison to conventional thin film surface plasmon resonance (SPR). These optical properties can be tuned by varying the physical aspects of the microplasmonic structures. Triangles and microhole arrays were prepared with modified nanosphere lithography (NSL) using latex spheres of 0.65, 0.82, 1.0, 1.5, or 3.2 pm in diameter. This allowed the preparation of triangles with edge lengths between 275 to 2000 nm and microhole arrays of various periodicities, diameters, and hole depths. These microstructures were studied to understand the relationship between the physical aspects and the optical properties, such as the sensitivity, working refractive index range, spectral width of the plasmonic peaks, spectral noise, and refractive index resolution. Microhole arrays with a hole diameter equal to half the periodicity were found to combine the advantages of both localized surface plasmon resonance (LSPR) on nanoparticles and SPR on a thin film. These microhole arrays exhibited high sensitivity to refractive index (>3000 nm/RIU), sensitivity to monolayer formation (2-fold improvement compared to thin films), and excellent refractive index resolution (10-6 RIU). Finally, a biosensor for the detection of 10 nM of immunoglobulin G (lgG) exhibited a greater response with microplasmonic materials compared to conventional thin Au films. Hence, these novel plasmonic materials exhibit a strong potential as an SPR sensing platform. They can be implemented on existing insinimentation and use detection protocols developed for current SPR sensors. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
190. SPR Biosensing in Crude Serum Using Ultralow Fouling Binary Patterned Peptide SAM.
- Author
-
Bolduc, Olivier R., PelIetier, Joelle N., and Masson, Jean-Francois
- Subjects
- *
SURFACE plasmon resonance , *PEPTIDES , *CARBOXYLIC acids , *AMINO acids , *IMMUNOGLOBULIN G , *SERUM , *ELECTROCHEMICAL analysis - Abstract
Near-zero fouling monolayers based on binaiy patterned peptides allow low nanomolar detection of the matrix metalloproteinase-3 (MMP-3) directly in crude bovine serum, without sample pretreatment, secondary antibody detection or signal amplification. The peptide 3-MPA-HHHDD-OH (3-MPA, 3-mercaptopropionic acid) was found optimal compared to other binary patterned peptides based on 3-MPA-Ax-By-OH, where 0 ⩽ x, y ⩽ 5, and x + y = 5, and compared to PEG. In this study, amino acid A was His, Asp, Ser, or Leu, and amino acid B was His, Asp, or Ser. Zwitterionic peptides and other peptides exhibited excellent resistance to non-specific adsorption. Binary patterned peptides were capped with 3-MPA on the N-terminus providing a monolayer with the C-terminus carboxylic acid available to subsequently immobilize antibodies. Thereby, an IgG biosensor demonstrated the efficiency of binary patterned peptides in SPR biosensingwith a detection limit of 1-10 μM In PBS, similar to other optical or electrochemical techniques. This protocol was applied to establish a calibration curve for MMP-3, an analyte of clinical interest for many pathologies and a potential indicator of cancer. The LOD for MMP-3 was 0.14 nM in PBS, with a linearity of up to 50 nM. With the use of PBS calibration, MMP-3 was quantified at low nanomolar in undiluted bovine serum. The SPR response in serum was statistically the same as in PBS. A sensor exposed to blank serum exhibited negligible nonspecific adsorption. Hence, binary patterned peptides are suitable for bio-sensing directly in complex biological matrixes. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
191. Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native, B.1.351, B.1.617.2, and P.1 SARS-CoV-2 spike proteins.
- Author
-
Hojjat Jodaylami, Maryam, Djaïleb, Abdelhadi, Ricard, Pierre, Lavallée, Étienne, Cellier-Goetghebeur, Stella, Parker, Megan-Faye, Coutu, Julien, Stuible, Matthew, Gervais, Christian, Durocher, Yves, Desautels, Florence, Cayer, Marie-Pierre, de Grandmont, Marie Joëlle, Rochette, Samuel, Brouard, Danny, Trottier, Sylvie, Boudreau, Denis, Pelletier, Joelle N., and Masson, Jean-Francois
- Subjects
- *
COVID-19 , *SARS-CoV-2 , *HUMORAL immunity , *CROSS reactions (Immunology) , *VACCINE effectiveness , *IMMUNOGLOBULINS - Abstract
SARS-CoV-2 variants of concern (VOCs) have emerged worldwide, with implications on the spread of the pandemic. Characterizing the cross-reactivity of antibodies against these VOCs is necessary to understand the humoral response of non-hospitalized individuals previously infected with SARS-CoV-2, a population that remains understudied. Thirty-two SARS-CoV-2-positive (PCR-confirmed) and non-hospitalized Canadian adults were enrolled 14–21 days post-diagnosis in 2020, before the emergence of the B.1.351 (also known as Beta), B.1.617.2 (Delta) and P.1 (Gamma) VOCs. Sera were collected 4 and 16 weeks post-diagnosis. Antibody levels and pseudo-neutralization of the ectodomain of SARS-CoV-2 spike protein/human ACE-2 receptor interaction were analyzed with native, B.1.351, B.1.617.2 and P.1 variant spike proteins. Despite a lower response observed for the variant spike proteins, we report evidence of a sustained humoral response against native, B.1.351, B.1.617.2 and P.1 variant spike proteins among non-hospitalized Canadian adults. Furthermore, this response inhibited the interaction between the spike proteins from the different VOCs and ACE-2 receptor for ≥ 16 weeks post-diagnosis, except for individuals aged 18–49 years who showed no inhibition of the interaction between B.1.617.1 or B.1.617.2 spike and ACE-2. Interestingly, the affinity (KD) measured between the spike proteins (native, B.1.351, B.1.617.2 and P.1) and antibodies elicited in sera of infected and vaccinated (BNT162b2 and ChAdOx1 nCoV-19) individuals was invariant. Relative to sera from vaccine-naïve (and previously infected) individuals, sera from vaccinated individuals had higher antibody levels (as measured with label-free SPR) and more efficiently inhibited the spike–ACE-2 interactions, even among individuals aged 18–49 years, showing the effectiveness of vaccination. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
192. Controllable design of polycrystalline synergies: Hybrid FeOx nanoparticles applicable to electrochemical sensing antineoplastic drug in mammalian cells.
- Author
-
Zhou, Haifeng, Chen, Dejian, Ran, Guoxia, Song, Qijun, and Masson, Jean-Francois
- Subjects
- *
SINGLE crystals , *FLUTAMIDE , *ELECTRIC conductivity , *POLYCRYSTALS , *NANOPARTICLES - Abstract
Graphical abstract Highlights • FeOx overcome single crystal phases generally suffering from serious agglomeration and poor electrical conductivity. • The synergistic effect between the electrocatalytic property and the polycrystalline structure of FeOx was verified. • Hybrid FeOx with variable oxidation states remarkably facilitate the efficient redox charge transfer. Abstract Investigations on interplay between sensing platform performance and crystal phase of material are the new beginning of designing advanced bioanalytical systems. Herein, FeO x nanoparticles (NPs, ∼100 nm), including superfine magnetic (Fe 3 O 4) and hematite (α-Fe 2 O 3) nanocrystals in single particles, have been employed to verify the synergistic effect between the electrocatalytic property and the polycrystalline structure of the materials. Moreover, this strategy overcomes that single crystal phases generally suffer from serious agglomeration and poor electrical conductivity. More importantly, hybrid metal oxides (e.g., α-Fe 2 O 3 /Fe 3 O 4) with variable oxidation states remarkably facilitate the efficient redox charge transfer. Taking the detection of Flutamide (FLT) in prostate cancer cells (VCaP cells) as example, the dynamic ranges of the oxidation states from the different crystal phases were integrated into a single electrochemical sensor interface. Furthermore, good selectivity, accuracy, satisfactory sensitivity (769.1 μA mM−1 cm-2) and low detection limits (46.6 nM) were achieved. Going beyond the conventional single-crystal phase-driven electrochemical sensing, the elaborate of polycrystalline structure in a single particle may open a new approach for the design of outstanding electrode materials, which not only can significantly improve the performance of sensing platforms, but also can be used to rationally design the material properties according to the applications. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
193. Fiber-optic surface plasmon resonance glucose sensor enhanced with phenylboronic acid modified Au nanoparticles.
- Author
-
Yuan, Huizhen, Ji, Wei, Chu, Shuwen, Qian, Siyu, Wang, Fang, Masson, Jean-Francois, Han, Xiuyou, and Peng, Wei
- Subjects
- *
SURFACE plasmon resonance , *BORONIC acids , *GOLD nanoparticles , *MONOMOLECULAR films , *ELECTROCHEMICAL sensors - Abstract
A highly sensitive surface plasmon resonance (SPR) sensor is reported for glucose detection using self-assembled p-mercaptophenylboronic acid (PMBA) monolayer on Au coated optical fibers. The cis-diol group of saccharides, such as for glucose, interacted with the self-assembled PMBA monolayers on the optical fibers, but the low molecular mass of glucose is insufficient for measuring a significant shift in SPR wavelength. The response for glucose was thus enhanced with Au nanoparticles (Au NPs) modified with 2-aminoethanethiol (AET) and PMBA. Selectivity was assured since glucose has the ability to capture the signal amplification tags (Au NPs/AET- PMBA) through secondary binding with another set of syn-periplanar diol groups and the PMBA on the gold surface. Accordingly, a glucose concentration-dependent sandwich structure was formed and the coupling between Au NPs and Au film results in the red shift of SPR resonance wavelength. The experimental results demonstrated that this SPR sensor responded to glucose within a range of 0.01–30 mM better than to fructose and galactose. The minimum concentration for quantify glucose is as low as 80 nM, which is lower than the physiological blood glucose level. Glucose was then accurately detected in urine sample, which indicated the potential application of the sensor for the analysis of glucose in urine. We believe that our proposed PMBA-modified single amplification tag and sensing principle can also be used for biomolecules consisting of carbohydrate structures, particularly for DNA-associated bioanalysis. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
194. Hybridization conditions of oligonucleotide-capped gold nanoparticles for SPR sensing of microRNA.
- Author
-
Hong, Long, Lu, Mengdi, Dinel, Marie-Pier, Blain, Philippe, Peng, Wei, Gu, Hongya, and Masson, Jean-Francois
- Subjects
- *
OLIGONUCLEOTIDES , *GOLD nanoparticles , *SURFACE plasmon resonance , *MICRORNA , *CANCER diagnosis - Abstract
MicroRNA (miRNA) sensing, especially the miRNA-200 family, is increasingly targeted for cancer diagnostics. As the sensing schemes often rely on nanoparticles functionalized with a specific oligonucleotide, we investigate the hydribization conditions using the common case of surface plasmon resonance (SPR) sensing of miRNA and a gold nanoparticle (Au NP) competitor. In this type of assays, the Au NPs compete with the microRNA to bind the capture probe immobilized on the gold surface. In our study, we simplify and improve the detection procedure by adopting 11-mercaptoundecanoic acid (11-MUA) as linker to the gold surface, not only omitting the blocking step of 6-mercapto-1-hexanol (MCH), but also increasing the probe density. We report that the response in our SPR sensing studies increased with the size of Au NPs according to the plasmon ruler equation, but the larger AuNPs of 32 nm lacked colloidal stability. In addition, decreasing the ratio of oligonucleotide to Au NPs and the addition of polyethylene glycol (PEG) to hybridization buffer also favored a better response in SPR sensing of miRNA. The optimization led to an improved detection sensitivity in our competition method and a detection limit as low as 500 pM for miRNA-200b without amplification of miRNA and use of other amplification schemes. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
195. Optimization of Surface Plasmon Resonance Biosensor with Ag/Au Multilayer Structure and Fiber-Optic Miniaturization.
- Author
-
Lu, Mengdi, Liang, Yuzhang, Qian, Siyu, Li, Lixia, Jing, Zhenguo, Masson, Jean-Francois, and Peng, Wei
- Subjects
- *
SURFACE plasmon resonance , *REFRACTIVE index measurement , *OPTICAL fibers , *COST effectiveness , *OPTICAL fiber detectors - Abstract
In this paper, we report a novel wavelength interrogation-based surface plasmon resonance (SPR) system, in which a film of three Ag layers and three Au layers are alternately deposited on a Kretschmann configuration as sensing element. This multilayer film shows higher sensitivity for refractive index (RI) measurement by comparing with single Au layer structure, which is consistent with its theoretical calculation. A sensitivity range of 2056-5893 nm/RIU can be achieved, which is comparable to RI sensitivities of other wavelength-modulated SPR sensors. Compared with Ag film, this Ag/Au multilayer arrangement offers anti-oxidant protection. This SPR biosensor based on a cost-effective Ag/Au multilayer structure is applicable to the real-time detection of specific interactions and dissociation of low protein concentrations. To extend the application of this highly-sensitive metal film device, we integrated this concept on an optical fiber. The range of RI sensitivities with Ag/Au multilayer was 1847-3309 nm/RIU. This miniaturized Ag/Au multilayer-based fiber optic sensor has a broad application in chemical and biological sensing. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
196. Metallic Nanowire Array-Polymer Hybrid Film for Surface Plasmon Resonance Sensitivity Enhancement and Spectral Range Enlargement.
- Author
-
Peng, Wei, Liang, Yuzhang, Li, Lixia, and Masson, Jean-Francois
- Subjects
- *
POLYMER film analysis , *METALLIC films , *SURFACE plasmon resonance , *NANOSTRUCTURES , *BIOSENSORS - Abstract
In this paper, the coupling interaction is investigated between a metallic nanowire array and a metal film under the Kretschmann condition. The plasmonic multilayer is composed of a metallic nanowire array embedded in a polymer layer positioned above a metal film, exploiting the classical surface plasmon resonance (SPR) configuration. We analyze the influence of various structural parameters of the metallic nanowire array on the SPR spectrum of thin metal film. The results show that the coupling interactions of nanowires with the metal film can greatly affect SPR resonance wavelength and increase SPR sensitivity. The coupling strength of metallic nanowire array and metal film also impacts resonance wavelength, which can be used to adjust SPR range but have little effect on its sensitivity. The results are confirmed using a dipole coupling resonance model of metallic nanowire. We demonstrated that this nanostructured hybrid structure can be used for high sensitivity SPR monitoring in a large spectral range, which is important for advanced SPR measurement including fiber-optic SPR sensing technology. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
197. Author Correction: Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native, B.1.351, B.1.617.2, and P.1 SARS-CoV-2 spike proteins.
- Author
-
Hojjat Jodaylami, Maryam, Djaïleb, Abdelhadi, Ricard, Pierre, Lavallée, Étienne, Cellier-Goetghebeur, Stella, Parker, Megan-Faye, Coutu, Julien, Stuible, Matthew, Gervais, Christian, Durocher, Yves, Desautels, Florence, Cayer, Marie-Pierre, de Grandmont, Marie Joëlle, Rochette, Samuel, Brouard, Danny, Trottier, Sylvie, Boudreau, Denis, Pelletier, Joelle N., and Masson, Jean-Francois
- Subjects
- *
COVID-19 , *SARS-CoV-2 , *CROSS reactions (Immunology) , *PROTEINS - Abstract
These authors contributed equally: Maryam Hojjat Jodaylami, Abdelhadi Djaïleb and Pierre Ricard. Correction to: I Scientific Reports i https://doi.org/10.1038/s41598-021-00844-z, published online 08 November 2021 The original version of this Article contained an error in the spelling of the author Stella Cellier-Goetghebeur which was incorrectly given as Stella Cellier-Goethebeur. [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF
198. Theory of polymer-entrapped enzyme ultramicroelectrodes: Application to glucose and adenosine triphosphate detection
- Author
-
Kottke, Peter A., Kranz, Christine, Kwon, Yong Koo, Masson, Jean-Francois, Mizaikoff, Boris, and Fedorov, Andrei G.
- Subjects
- *
BIOSENSORS , *ADENINE nucleotides , *ADENOSINE triphosphate , *PURINE nucleotides - Abstract
Abstract: We validate, by comparison with experimental data, a theoretical description of the amperometric response of microbiosensors formed via enzyme entrapment. The utility of the theory is further illustrated with two relevant examples supported by experiments: (1) quantitative detection of glucose and (2) quantitative detection of adenosine triphosphate (ATP). [Copyright &y& Elsevier]
- Published
- 2008
- Full Text
- View/download PDF
199. Theory of polymer entrapped enzyme ultramicroelectrodes: Fundamentals
- Author
-
Kottke, Peter A., Kranz, Christine, Kwon, Yong Koo, Masson, Jean-Francois, Mizaikoff, Boris, and Fedorov, Andrei G.
- Subjects
- *
POLYMERS , *ULTRAMICROELECTRODES , *MICROELECTRODES , *CHEMICAL kinetics - Abstract
Abstract: We have developed a theoretical description of the amperometric response of ultramicroelectrode (UME) biosensors formed via enzyme entrapment. Our model allows for multiple enzymes and co-substrates, and results in a closed-form analytical expression for the steady-state current response of the disk ultramicroelectrode. It captures the effects of enzyme-entrapment domain size, species transport properties (which can be different in the polymer and surrounding electrolyte), enzyme kinetics, and axisymmetric diffusion. Assumptions inherent in the derivation are carefully explained, as are the resulting limits on the applicability of the results. The ability to theoretically predict the response of enzyme entrapped UMEs should enable improved design, operation, and data interpretation for this important class of biosensors. [Copyright &y& Elsevier]
- Published
- 2008
- Full Text
- View/download PDF
200. Comparative study of block copolymer-templated localized surface plasmon resonance optical fiber biosensors: CTAB or citrate-stabilized gold nanorods.
- Author
-
Lu, Mengdi, Zhu, Hu, Lin, Ming, Wang, Fang, Hong, Long, Masson, Jean-Francois, and Peng, Wei
- Subjects
- *
SURFACE plasmon resonance , *CITRATES , *OPTICAL resonance , *OPTICAL fibers , *OPTICAL fiber detectors , *BIOSENSORS , *MANUFACTURING processes - Abstract
• An optical fiber LSPR biosensor via diblock copolymer-templated AuNRs monolayer was reported. • PS- b -PV4P-templated citrate-AuNR film led to higher RI sensitivity than that of PS- b -PAA-templated CTAB-AuNR film. • PS- b -PV4P-templated biosensor exhibited better spectral characteristics than polyelectrolyte and APTES-based biosensors. • PS- b -PV4P-templated biosensor exhibited an excellent response to human IgG with LOD of 0.6 nM. Block copolymer (BCP) brush-like layer absorbed on optical fibers are shown to address the longstanding challenge of forming dense and well-dispersed gold nanorods (AuNRs) films on highly curved surface, allowing the development of real-time localized surface plasmon resonance (LSPR) biosensors for antigen-antibody interaction. This method requires only solution-based manufacturing processes and a plasma cleaning step to self-assemble AuNRs with various aspect ratios on the optical fibers. Because AuNRs capped with cetyltrimethylammonium bromide (CTAB) have been problematic for biosensing applications due to their cytotoxicity and displacement difficulty in the construction of biosensors, citrate-stabilized AuNRs were prepared from CTAB-stabilized AuNRs via surfactant exchange. For comparison, both a poly(styrene)- b -poly(acrylic acid) (PS- b -PAA) BCP template with CTAB-stabilized AuNRs and a poly(styrene)- b -poly(4-vinyl pyridine) (PS- b -P4VP) BCP template with citrate-stabilized AuNRs were employed for the fabrication of the optical fiber biosensor. The LSPR spectral analysis results demonstrate that the sensitivity of the sensor produced by the PS- b -P4VP templating method was 1.5 times better than that of the sensor produced by the PS- b -PAA templating method, which was due to the improved surface coverage and reduced aggregation of nanoparticles. The detection limit of the PS- b -P4VP-templated sensor for human IgG was 0.6 nM. Furthermore, for citrate-stabilized AuNRs, the PS- b -P4VP templating method also led to a better surface morphology and higher sensitivity as compared to the standard particle absorption methods using alkoxysilanes or polyelectrolytes on identical fibers. The simplicity of the fabrication process and the far superior optical performance of the PS- b -P4VP-templated LSPR optical fiber sensor illustrate the ability to regulate the detection range by tuning the aspect ratios of the AuNRs, and demonstrate its application prospects as a real-time biosensor without cytotoxicity. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.