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1,457 results on '"Masliah, E"'

153. An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease

Author

Masliah, E., Mallory, M., Hansen, L., Alford, M., DeTeresa, R., and Terry, R.

Subjects
Aged, 80 and over, Intermediate Filaments, Antibodies, Monoclonal, Brain, Hippocampus, Immunohistochemistry, Axons, Frontal Lobe, nervous system, Alzheimer Disease, mental disorders, Neurites, Humans, Phosphorylation, Research Article, Aged
Abstract

We studied axonal damage in Alzheimer's disease frontal cortex and hippocampus with a novel monoclonal antibody (SMI 312) against phosphorylated neurofilaments. This antibody immunolabeled, with great detail, the neuropil axonal network. In aged normal cases only a few pyramidal cell perikarya were immunostained. In Alzheimer's disease there was a two- to four-fold increase in neuronal SMI 312 immunolabeling, and neuropil neuritic processes were severely disrupted. Double-immunolabeling analysis showed that 88% of SMI 312-immunolabeled abnormal neuritic clusters were associated with amyloid, whereas the remaining 12% were not. Serial section analysis and 3-D reconstructions suggested that dystrophic neurites of classical plaques were derived from long axons. These abnormal neurites were also growth-associated protein 43 positive and occasionally tau positive. The present study supports the contention that a subpopulation of aberrantly sprouting axons in the neuritic plaque is derived from cortico-cortico fibers. This disruption of the neocortical association fibers and neuritic microcircuitry could underlie the cognitive impairment of Alzheimer's disease.

Published
1993

164. Casein kinase II alteration precedes tau accumulation in tangle formation

Author

Masliah, E., Iimoto, D. S., Mallory, M., Albright, T., Hansen, L., and Saitoh, T.

Subjects
Alzheimer Disease, Humans, Neurofibrillary Tangles, tau Proteins, Autopsy, Protein Serine-Threonine Kinases, Casein Kinase II, Microscopy, Immunoelectron, Hippocampus, Immunohistochemistry, Research Article, Aged
Abstract

Previous studies have shown altered casein kinase II (CK-II) in Alzheimer's disease (AD). For the present study, the authors analyzed CK-II immunoreactivity at various stages of tangle formation using quantitative laser confocal microscopy and immunoelectron microscopy. AD hippocampal pyramidal cells without neurofibrillary tangles (NFTs) displayed 15% more anti-tau immunoreactivity (P less than 0.01) and 43% more anti-CKII immunolabeling than controls (P less than 0.001). In AD, tangle-bearing hippocampal neurons with strong anti-tau immunoreactivity (threefold increase from controls) showed a significant 22% increase in anti-CKII immunolabeling (P less than 0.01), compared with those without NFTs. Neurons with early neurofibrillary changes showed diffuse anti-CKII immunostaining in their cytoplasm and cell processes. In tangle-bearing neurons, in which a higher level of tau immunoreactivity was detected, anti-CKII immunolabeling was distributed along a fibrillar meshwork in cell bodies and processes. Linear regression analysis of anti-CKII and anti-tau immunoreactivity in AD showed a positive correlation (r = 0.53, P less than 0.001). At the ultrastructural level, anti-CKII was immunolocalized to the paired helical filaments (PHF) of the tangle-bearing neurons, as well as to PHF in neuropil threads and some dystrophic neurites in plaques. These results suggest a possible role for CK-II in tangle formation.

Published
1992

168. DLB and PDD boundary issues

Author

Lippa, C. F., primary, Duda, J. E., additional, Grossman, M., additional, Hurtig, H. I., additional, Aarsland, D., additional, Boeve, B. F., additional, Brooks, D. J., additional, Dickson, D. W., additional, Dubois, B., additional, Emre, M., additional, Fahn, S., additional, Farmer, J. M., additional, Galasko, D., additional, Galvin, J. E., additional, Goetz, C. G., additional, Growdon, J. H., additional, Gwinn-Hardy, K. A., additional, Hardy, J., additional, Heutink, P., additional, Iwatsubo, T., additional, Kosaka, K., additional, Lee, V. M.-Y., additional, Leverenz, J. B., additional, Masliah, E., additional, McKeith, I. G., additional, Nussbaum, R. L., additional, Olanow, C. W., additional, Ravina, B. M., additional, Singleton, A. B., additional, Tanner, C. M., additional, Trojanowski, J. Q., additional, and Wszolek, Z. K., additional

Published
2007
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