Search

Your search keyword '"Maruyama, Katsuya"' showing total 631 results
Start Over Author "Maruyama, Katsuya"
631 results on '"Maruyama, Katsuya"'

153. Development of squamous neoplasia in esophageal iodine‐unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men

Author

Yokoyama, Akira, primary, Hirota, Teruyuki, additional, Omori, Tai, additional, Yokoyama, Tetsuji, additional, Kawakubo, Hirofumi, additional, Matsui, Toshifumi, additional, Mizukami, Takeshi, additional, Mori, Shuka, additional, Sugiura, Hitoshi, additional, and Maruyama, Katsuya, additional

Published
2011
Full Text
View/download PDF

163. Contrast-enhanced MR Imaging of Metastatic Brain Tumor at 3 Tesla: Utility of T1-weighted SPACE Compared with 2D Spin Echo and 3D Gradient Echo Sequence

Author

KOMADA, Tomohiro, primary, NAGANAWA, Shinji, additional, OGAWA, Hiroshi, additional, MATSUSHIMA, Masaya, additional, KUBOTA, Seiji, additional, KAWAI, Hisashi, additional, FUKATSU, Hiroshi, additional, IKEDA, Mitsuru, additional, KAWAMURA, Minako, additional, SAKURAI, Yasuo, additional, and MARUYAMA, Katsuya, additional

Published
2008
Full Text
View/download PDF

165. 13C MRS reveals a small diurnal variation in the glycogen content of human thigh muscle.

Author

Takahashi, Hideyuki, Kamei, Akiko, Osawa, Takuya, Kawahara, Takashi, Takizawa, Osamu, and Maruyama, Katsuya

Abstract

There is marked diurnal variation in the glycogen content of skeletal muscles of animals, but few studies have addressed such variations in human muscles. 13C MRS can be used to noninvasively measure the glycogen content of human skeletal muscle, but no study has explored the diurnal variations in this parameter. This study aimed to investigate whether a diurnal variation in glycogen content occurs in human muscles and, if so, to what extent it can be identified using 13C MRS. Six male volunteers were instructed to maintain their normal diet and not to perform strenuous exercise for at least 3 days before and during the experiment. Muscle glycogen and blood glucose concentrations were measured six times in 24 h under normal conditions in these subjects. The glycogen content in the thigh muscle was determined noninvasively by natural abundance 13C MRS using a clinical MR system at 3 T. Nutritional analysis revealed that the subjects' mean carbohydrate intake was 463 ± 137 g, being approximately 6.8 ± 2.4 g/kg body weight. The average sleeping time was 5.9 ± 1.0 h. The glycogen content in the thigh muscle at the starting point was 64.8 ± 20.6 mM. Although absolute and relative individual variations in muscle glycogen content were 7.0 ± 2.1 mM and 11.3 ± 4.6%, respectively, no significant difference in glycogen content was observed among the different time points. This study demonstrates that normal food intake (not fat and/or carbohydrate rich), sleep and other daily activities have a negligible influence on thigh muscle glycogen content, and that the diurnal variation of the glycogen content in human muscles is markedly smaller than that in animal muscles. Moreover, the present results also support the reproducibility and availability of 13C MRS for the evaluation of the glycogen content in human muscles. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

182. Cystic Ovarian Lesions in SSFP Diffusion Imaging

Author

KAJI, Yasushi, primary, MATSUO, Michimasa, additional, MATSUKI, Mitsuru, additional, YOSHIDA, Masumi, additional, HAYASHI, Michiharu, additional, NANNO, Hidetaka, additional, KOSHIYAMA, Masafumi, additional, FUJII, Haruko, additional, MARUYAMA, Katsuya, additional, TAKIZAWA, Osamu, additional, and SUGIMURA, Kazuro, additional

Published
2002
Full Text
View/download PDF

185. Angiotensin AT 1 and AT 2 Receptors Differentially Regulate Angiopoietin-2 and Vascular Endothelial Growth Factor Expression and Angiogenesis by Modulating Heparin Binding–Epidermal Growth Factor (EGF)–Mediated EGF Receptor Transactivation

Author

Fujiyama, Soichiro, primary, Matsubara, Hiroaki, additional, Nozawa, Yoshihisa, additional, Maruyama, Katsuya, additional, Mori, Yasukiyo, additional, Tsutsumi, Yoshiaki, additional, Masaki, Hiroya, additional, Uchiyama, Yoko, additional, Koyama, Yoko, additional, Nose, Atsuko, additional, Iba, Osamu, additional, Tateishi, Eriko, additional, Ogata, Nahoko, additional, Jyo, Nobuo, additional, Higashiyama, Shigeki, additional, and Iwasaka, Toshiji, additional

Published
2001
Full Text
View/download PDF

191. Alcoholic Ketosis: Prevalence, Determinants, and Ketohepatitis in Japanese Alcoholic Men.

Author

Yokoyama, Akira, Yokoyama, Tetsuji, Mizukami, Takeshi, Matsui, Toshifumi, Shiraishi, Koichi, Kimura, Mitsuru, Matsushita, Sachio, Higuchi, Susumu, and Maruyama, Katsuya

Subjects
COMPLICATIONS of alcoholism, ACADEMIC medical centers, ACIDOSIS, ANALYSIS of covariance, BLOOD testing, CONFIDENCE intervals, CIRRHOSIS of the liver, METABOLISM, MULTIVARIATE analysis, STATISTICS, SURVEYS, URINALYSIS, LOGISTIC regression analysis, CROSS-sectional method, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio, MANN Whitney U Test, GENOTYPES, DISEASE risk factors
Abstract

Aims: Alcoholic ketosis and ketoacidosis are metabolic abnormalities often diagnosed in alcoholics in emergency departments. We attempted to identify determinants or factors associated with alcoholic ketosis. Methods: The subjects of this cross-sectional survey were 1588 Japanese alcoholic men (≥40 years) who came to an addiction center within 14 days of their last drink. Results: The results of the dipstick urinalyses revealed a prevalence of ketosis of 34.0% (±, 21.5%; +, 8.9%; and 2+/3+; 3.6%) in the alcoholics. Higher urine ketone levels were associated with higher serum total bilirubin, aspartate transaminase (AST), alanine transaminase and gamma-glutamyl transpeptidase levels. A multivariate analysis by the proportional odds model showed that the odds ratio (95% confidence interval) for an increase in ketosis by one category was 0.94 (0.84–1.06) per 10-year increase in age, 0.93 (0.89–0.97) per 1-day increase in interval since the last drink, 1.78 (1.41–2.26) in the presence of slow-metabolizing alcohol dehydrogenase-1B (ADH1B*1/*1), 1.61 (1.10–2.36) and 1.30 (1.03–1.65) when the beverage of choice was whiskey and shochu, respectively (distilled no-carbohydrate beverages vs. the other beverages), 2.05 (1.27–3.32) in the presence of hypoglycemia <80 mg/dl, 0.91 (0.88–0.94) per 1-kg/m2 increase in body mass index (BMI), 1.09 (1.00–1.18) per +10 cigarettes smoked, and 2.78 (2.05–3.75) when the serum total bilirubin level was ≥2.0 mg/dl, and 1.97 (1.47–2.66) when the serum AST level was ≥200 IU/l. Conclusion: Ketosis was a very common complication and frequently accompanied by alcoholic liver injury in our Japanese male alcoholic population, in which ADH1B*1/*1 genotype, consumption of whiskey or shochu, hypoglycemia, lower BMI and smoking were significant determinants of the development of ketosis. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

192. Radial volumetric imaging breath-hold examination (VIBE) with k-space weighted image contrast (KWIC) for dynamic gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI of the liver: advantages over Cartesian VIBE in the arterial phase.

Author

Fujinaga, Yasunari, Ohya, Ayumi, Tokoro, Hirokazu, Yamada, Akira, Ueda, Kazuhiko, Ueda, Hitoshi, Kitou, Yoshihiro, Adachi, Yasuo, Shiobara, Aya, Tamaru, Naomichi, Nickel, Marcel, Maruyama, Katsuya, and Kadoya, Masumi

Subjects
HEPATIC artery, LIVER, ABDOMINAL aorta, MAGNETIC resonance imaging, IMAGE quality in radiography
Abstract

Objectives: To compare radial volumetric imaging breath-hold examination with k-space weighted image contrast reconstruction (r-VIBE-KWIC) to Cartesian VIBE (c-VIBE) in arterial phase dynamic gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (DCE-MRI) of the liver. Methods: We reviewed 53 consecutive DCE-MRI studies performed on a 3-T unit using c-VIBE and 53 consecutive cases performed using r-VIBE-KWIC with full-frame image subset (r-VIBE) and sub-frame image subsets (r-VIBE; temporal resolution, 2.5-3 s). All arterial phase images were scored by two readers on: (1) contrast-enhancement ratio (CER) in the abdominal aorta; (2) scan timing; (3) artefacts; (4) visualisation of the common, right, and left hepatic arteries. Results: Mean abdominal aortic CERs for c-VIBE, r-VIBE, and r-VIBE were 3.2, 4.3 and 6.5, respectively. There were significant differences between each group ( P < 0.0001). The mean score for c-VIBE was significantly lower than that for r-VIBE and r-VIBE in all factors except for visualisation of the common hepatic artery ( P < 0.05). The mean score of all factors except for scan timing for r-VIBE was not significantly different from that for r-VIBE. Conclusions: Radial VIBE-KWIC provides higher image quality than c-VIBE, and r-VIBE features high temporal resolution without image degradation in arterial phase DCE-MRI. Key Points: • Radial VIBE-KWIC minimised artefact and produced high-quality and high-temporal-resolution images. • Maximum abdominal aortic enhancement was observed on sub-frame images of r-VIBE-KWIC. • Using r-VIBE-KWIC, optimal arterial phase images were obtained in over 90 %. • Using r-VIBE-KWIC, visualisation of the hepatic arteries was improved. • A two-reader study revealed r-VIBE-KWIC's advantages over Cartesian VIBE. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

193. Macrocytosis, Macrocytic Anemia, and Genetic Polymorphisms of Alcohol Dehydrogenase-1 B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.

Author

Yokoyama, Akira, Yokoyama, Tetsuji, Brooks, Philip J., Mizukami, Takeshi, Matsui, Toshifumi, Kimura, Mitsuru, Matsushita, Sachio, Higuchi, Susumu, and Maruyama, Katsuya

Subjects
COMPLICATIONS of alcoholism, MACROCYTIC anemia, ERYTHROCYTES, ALCOHOL dehydrogenase, ALCOHOLIC beverages, ALDEHYDES, ANALYSIS of covariance, CHI-squared test, CONFIDENCE intervals, EPIDEMIOLOGY, ETHANOL, GENES, GENETIC polymorphisms, POLYMERASE chain reaction, SMOKING, STATISTICS, T-test (Statistics), U-statistics, DATA analysis, BODY mass index, DATA analysis software, DESCRIPTIVE statistics, DISEASE risk factors
Abstract

Background Oxidation of ethanol by alcohol dehydrogenase ( ADH) generates acetaldehyde (AcH), which is converted to acetate by aldehyde dehydrogenase-2 ( ALDH2). Roughly 40% of East Asians are ALDH2-deficient due to an inactive enzyme encoded by the ALDH2*2 allele. ALDH2-deficient individuals have a dramatically elevated risk of esophageal cancer from alcohol consumption. Methods We investigated the relationship between ALDH2*2, ADH1 B*2 (encoding a highly active ADH) and erythrocyte abnormalities, in a population of Japanese alcoholic men ( N = 1,238). Results Macrocytosis ( mean corpuscular volume [MCV] ≥100 fl) and macrocytic anemia ( MCV ≥100 fl and hemoglobin <13.5 g/dl) were found in 62.4 and 24.1% of the subjects, respectively. Age-adjusted daily alcohol consumption did not differ according to ADH1 B and ALDH2 genotypes. However, macrocytosis and macrocytic anemia were strongly associated with the ALDH2*1/*2 genotype multivariate odds ratios ( ORs; 95% confidence interval [CI] = 2.85 [1.95 to 4.18] and 3.68 [2.64 to 5.15], respectively, versus ALDH2*1/*1). In comparison with the ADH1 B*1/*1 and ALDH2*1/*1 genotype combination, the ADH1 B*1/*1 and ALDH2*1/*2 genotype combination and the ADH1 B*2 allele and ALDH2*1/*2 genotype combination increased stepwise the ORs (95% CI) for macrocytosis (1.65 [0.92 to 2.94] and 4.07 [2.33 to 7.11], respectively, p for difference in OR = 0.015) and macrocytic anemia (2.80 [1.52 to 5.15] and 5.32 [3.29 to 8.62], respectively, p for difference in OR = 0.045). Genotype effects were more prominent on the risks of the more advanced erythrocyte abnormalities. Older age, cigarette smoking, and low body mass index independently increased the risks of the erythrocyte abnormalities. Consumption of beer, which contains folate, decreased the risks, whereas consumption of alcoholic beverages lacking folate did not. Conclusions These results suggest that the erythrocyte abnormalities in alcoholics are attributable to high AcH exposure as well as to nutritional deficiencies and may be prevented by folate. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

195. Angiotensin II–Induced Transactivation of Epidermal Growth Factor Receptor Regulates Fibronectin and Transforming Growth Factor-β Synthesis via Transcriptional and Posttranscriptional Mechanisms

Author

Moriguchi, Yasutaka, primary, Matsubara, Hiroaki, additional, Mori, Yasukiyo, additional, Murasawa, Satoshi, additional, Masaki, Hiroya, additional, Maruyama, Katsuya, additional, Tsutsumi, Yoshiaki, additional, Shibasaki, Yasunobu, additional, Tanaka, Yoko, additional, Nakajima, Takuma, additional, Oda, Kinichiro, additional, and Iwasaka, Toshiji, additional

Published
1999
Full Text
View/download PDF

197. Interleukin-1 Upregulates Cardiac Expression of Vascular Endothelial Growth Factor and its Receptor KDR/flk-1 via Activation of Protein Tyrosine Kinases

Author

Maruyama, Katsuya, primary, Mori, Yasukiyo, additional, Murasawa, Satoshi, additional, Masaki, Hiroya, additional, Takahashi, Nobuyuki, additional, Tsutusmi, Yoshiaki, additional, Moriguchi, Yasutaka, additional, Shibazaki, Yoshinobu, additional, Tanaka, Yoko, additional, Shibuya, Masabumi, additional, Inada, Mitsuo, additional, Matsubara, Hiroaki, additional, and Iwasaka, Toshiji, additional

Published
1999
Full Text
View/download PDF

199. Angiotensin II Type 2 Receptor Is Upregulated in Human Heart With Interstitial Fibrosis, and Cardiac Fibroblasts Are the Major Cell Type for Its Expression

Author

Tsutsumi, Yoshiaki, primary, Matsubara, Hiroaki, additional, Ohkubo, Naohiko, additional, Mori, Yasukiyo, additional, Nozawa, Yoshihisa, additional, Murasawa, Satoshi, additional, Kijima, Kazuhisa, additional, Maruyama, Katsuya, additional, Masaki, Hiroya, additional, Moriguchi, Yasutaka, additional, Shibasaki, Yasunobu, additional, Kamihata, Hiroshi, additional, Inada, Mitsuo, additional, and Iwasaka, Toshiji, additional

Published
1998
Full Text
View/download PDF

200. Role of Calcium-Sensitive Tyrosine Kinase Pyk2/CAKβ/RAFTK in Angiotensin II–Induced Ras/ERK Signaling

Author

Murasawa, Satoshi, primary, Mori, Yasukiyo, additional, Nozawa, Yoshihisa, additional, Masaki, Hiroya, additional, Maruyama, Katsuya, additional, Tsutsumi, Yoshiaki, additional, Moriguchi, Yasutaka, additional, Shibasaki, Yasunobu, additional, Tanaka, Yoko, additional, Iwasaka, Toshiji, additional, Inada, Mitsuo, additional, and Matsubara, Hiroaki, additional

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results