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155. Markov risk mappings and risk-sensitive optimal prediction

Author

Randall Martyr, John Moriarty, and Tomasz Kosmala

Subjects
FOS: Economics and business, Optimization and Control (math.OC), Quantitative Finance - Mathematical Finance, General Mathematics, Probability (math.PR), FOS: Mathematics, 60G40, 91B08, 91B06, 90C40, Management Science and Operations Research, Mathematical Finance (q-fin.MF), Mathematics - Optimization and Control, Mathematics - Probability, Software
Abstract

We formulate a probabilistic Markov property in discrete time under a dynamic risk framework with minimal assumptions. This is useful for recursive solutions to risk-sensitive versions of dynamic optimisation problems such as optimal prediction, where at each stage the recursion depends on the whole future. The property holds for standard measures of risk used in practice, and is formulated in several equivalent versions including a representation via acceptance sets, a strong version, and a dual representation., 21 pages. Improved introduction and a new result on the canonical form for a Markovian family of dynamic risk measures

Published
2022
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156. Longitudinal Predictors of Informant-Rated Involvement of People with Dementia in Everyday Decision-Making: Findings from the IDEAL Program

Author

Serena, Sabatini, Anthony, Martyr, Laura D, Gamble, Rachel, Collins, Fiona E, Matthews, Robin G, Morris, Jennifer M, Rusted, Claire, Pentecost, Catherine, Quinn, and Linda, Clare

Subjects
Geriatrics and Gerontology, Gerontology
Abstract

The extent to which people with dementia are involved in everyday decision-making is unclear. We explored informant-rated involvement of people with dementia in everyday decision-making over 2 years and whether functional, behavioral, and psychological factors related to the person with dementia and the caregiver explain variability in involvement of people with dementia in everyday decision-making. We used IDEAL data for 1182 people with dementia and their caregivers. Baseline mean score on the decision-making involvement scale was 31/45; it minimally declined over time. People with dementia who were female, single, and/or whose caregiver was younger had greater involvement in everyday decision-making than those without these characteristics. Better cognition, fewer functional difficulties, fewer neuropsychiatric symptoms, less caregiver stress, and better informant-rated relationship quality were associated with higher involvement in everyday decision-making. Cognitive and functional rehabilitation, and educational resources for caregivers, could prolong involvement of people with dementia in everyday decision-making.

Published
2022
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157. Electrochemical, Electrocatalytic, and Magnetic Properties of Vanadium-Containing Polyoxometalates

Author

Joseph Dika Manga, Anne-Lucie Teillout, Eric Rivière, Pedro de Oliveira, and Israël Martyr Mbomekallé

Subjects
polyoxometalates, vanadium, magnetism, electrochemistry, electroctalysis, Chemistry, QD1-999
Abstract

Mono-substituted vanadium-containing Dawson-type polyoxometalates having the general formula α1-[VIVW17X2O62]8− and α2-[VIVW17X2O62]8−, with X = As or P, were synthesised and subject to a comprehensive electrochemical study comprising the pH dependency. These POMs exhibit an electrocatalytic behaviour towards the oxidation of thiols (namely cysteine), rendering them interesting species for mimicking oxidative stress situations, at physiological pH values. The efficiency of the electro-oxidation was assessed with thiols of different nature, and the substrate that responded best was used to compare the electrocatalytic capabilities of the POM series. The magnetic behaviour of these POMs was also evaluated and compared to their analogues, α1- and α2-[VVW17X2O62]7− (X = As or P), at low temperatures and showed, as expected, a paramagnetic behaviour of VIV based compounds.

Published
2021
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159. Enhanced Oxygen Reduction Reaction Activity of the Wells‐Dawson Polyoxometalate P2W12Mo6 Immobilised in Nitrogen and Sulphur‐Doped Carbon Nanomaterials.

Author

Novais, Hugo C., Jarrais, Bruno, Mbomekallé, Israël‐Martyr, Teillout, Anne‐Lucie, de Oliveira, Pedro, Freire, Cristina, and Fernandes, Diana M.

Subjects
OXYGEN reduction, RENEWABLE energy sources, CLEAN energy, CARBON-based materials, METAL catalysts, NITROGEN
Abstract

As the world faces an escalating energy crisis, the necessity of adopting alternative energy sources becomes increasingly evident. Despite challenges, the imperative to prioritise these eco‐friendly alternatives remains paramount in paving the way for a more sustainable and resilient future for our planet and its inhabitants. The pursuit of sustainable energy sources has brought the oxygen reduction reaction (ORR) into the spotlight as a crucial cathodic reaction in energy‐converting systems, notably fuel cells (FCs). These FCs hold tremendous promise in providing an eco‐friendly and efficient energy supply. However, the widespread implementation of FCs is hindered by their reliance on expensive and scarce noble metal catalysts, such as platinum (Pt), which pose economic and environmental challenges. Hence, this work reports the preparation, characterisation (FTIR, XPS, SEM and EDX) and application of four composites based on doped‐carbon materials (CM) and on the Wells‐Dawson POM salt K6⋅α‐[P2W12Mo6O62] ⋅ 19H2O (P2W12Mo6@MWCNT_N8, P2W12Mo6@MWCNT_N6, P2W12Mo6@MWCNT_S6, and P2W12Mo6@GF_S6) as ORR electrocatalysts in alkaline medium (pH=13). The successful doping of the carbon materials with nitrogen (N) and sulphur (S) and the incorporation of the polyoxometalate were verified through comprehensive structural characterisation. Overall, P2W12Mo6@MWCNT_N8 exhibited favourable onset potentials of 0.84 V vs. RHE, highlighting its high catalytic activity. Additionally, the catalyst showed excellent tolerance to methanol crossover, retaining 91 % of initial current, which is crucial for practical fuel cell applications. Furthermore, the P2W12Mo6@MWCNT_N8 catalyst showed commendable stability, retaining 81 % of its initial current after 36000 seconds at an operating potential of E=0.46 V vs. RHE. These encouraging results denote the significant potential of this electrocatalyst in advancing sustainable energy conversion technologies. [ABSTRACT FROM AUTHOR]

Published
2024
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160. Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme.

Author

Martyr, Anthony, Ravi, Madhumathi, Gamble, Laura D., Morris, Robin G, Rusted, Jennifer M., Pentecost, Claire, Matthews, Fiona E., and Clare, Linda

Abstract

INTRODUCTION: Impaired cognition and instrumental activities of daily living (iADL) are key diagnostic features of dementia; however, few studies have compared trajectories of cognition and iADL. METHODS: Participants from the IDEAL study comprised 1537, 1183, and 851 people with dementia, and 1277, 977, and 749 caregivers at baseline, 12 and 24 months, respectively. Addenbrooke's Cognitive Examination‐III and Functional Activities Questionnaire were used to measure cognition and iADL, respectively. Scores were converted to deciles. RESULTS: Self‐rated iADL declined on average by ‐0.08 (‐0.25, 0.08) decile points per timepoint more than cognition. Informant‐rated iADL declined on average by ‐0.31 (‐0.43, ‐0.18) decile points per timepoint more than cognition. DISCUSSION: Cognition and self‐rated iADL declined at a similar rate. Informant‐rated iADL declined at a significantly greater rate than cognition. Therefore, either cognition and perceived iADL decline at different rates or informants overestimate increasing iADL difficulties compared to both cognition and self‐ratings. Highlights: Self‐ratings of the degree of functional difficulties were consistent with cognitionDecline in self‐rated everyday activities was consistent with cognitive declineInformant‐ratings of everyday activities declined more than cognition [ABSTRACT FROM AUTHOR]

Published
2024
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161. Methods and approaches to facilitate inclusion of the views, perspectives and preferences of people with moderate‐to‐severe dementia in research: A narrative systematic review.

Author

Collins, Rachel, Martyr, Anthony, Hunt, Anna, Quinn, Catherine, Pentecost, Claire, Hughes, Julian C., and Clare, Linda

Subjects
CINAHL database, PSYCHOLOGY information storage & retrieval systems, ONLINE information services, MEDICAL information storage & retrieval systems, SYSTEMATIC reviews, DEMENTIA patients, PATIENTS' attitudes, RESEARCH funding, MEDLINE, MEDICAL research
Abstract

Background: The perspectives of people with moderate‐to‐severe dementia are rarely directly elicited in research studies. Objectives: This systematic review will explore methods and approaches for including the perspectives and preferences of people with moderate‐to‐severe dementia in research. Methods: AgeLine, CINAHL, Embase, PsycINFO, PubMed, Social Policy and Practice and Web of Science were searched until June 16 2022. Study quality was assessed using the 16‐item Quality Assessment Tool. We described specific communication tools, reviewed the evidence for their effectiveness and considered their strengths and limitations. We examined the more general communication skills and techniques applied to support the use of these tools using thematic synthesis. The review protocol was registered with PROSPERO CRD42019130386 and the review was conducted and reported according to PRISMA guidelines. Results: Seven studies reported in 11 publications were included. In these studies five specific communication tools were used: Talking Mats, Augmentative and Alternative Communication Flexiboard, generic photographs in combination with a preference placement board, consultation ballot and personalised communication prescriptions. Each tool identified had advantages and disadvantages depending on dementia severity, verbal or physical ability, expense, researcher training requirements and ease of use. Thematic synthesis identified five general approaches to optimising communication that were employed to support use of the tools: ensuring conversations are individual and person‐centred, managing external influences, engaging others, creating structure and facilitation skills. Conclusion: All tools had some utility and there was no clear evidence to support the recommendation of any one specific tool; therefore, researchers are advised to select the tool most appropriate to their context. Implications for Practice: The findings offer general guidance for researchers and practitioners on how to facilitate communication with people with moderate‐to‐severe dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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166. Multiassay Profiling of a Focused Small Molecule Library Reveals Predictive Bidirectional Modulation of the lncRNA MALAT1 Triplex Stability

Author

Martina Zafferani, Justin G. Martyr, Dhanasheel Muralidharan, Nadeska I. Montalvan, Zhengguo Cai, and Amanda E. Hargrove

Subjects
Molecular Medicine, Humans, Nucleic Acid Conformation, RNA, Long Noncoding, General Medicine, Calorimetry, Biochemistry, Diminazene, Gene Library
Abstract

The rapidly accelerating characterization of RNA tertiary structures has revealed their pervasiveness and active roles in human diseases. Small molecule-mediated modulation of RNA tertiary structures constitutes an attractive avenue for the development of tools for therapeutically targeting and/or uncovering the pathways associated with these RNA motifs. This potential has been highlighted by targeting of the triple helix present at the 3'-end of the noncoding RNA MALAT1, a transcript implicated in several human diseases. This triplex has been reported to decrease the susceptibility of the transcript to degradation and promote its cellular accumulation. While small molecules have been shown to bind to and impact the stability of the MALAT1 triple helix, the small molecule properties that lead to these structural modulations are not well understood. We designed a library utilizing the diminazene scaffold, which is underexplored but precedented for nucleic acid binding, to target the MALAT1 triple helix. We employed multiple assays to holistically assess what parameters, if any, could predict the small molecule affinity and effect on triplex stability. We designed and/or optimized competition, calorimetry, and thermal shift assays as well as an enzymatic degradation assay, the latter of which led to the discovery of bidirectional modulators of triple helix stability within the scaffold-centric library. Determination of quantitative structure-activity relationships afforded predictive models for both affinity- and stability-based assays. This work establishes a suite of powerful orthogonal biophysical tools for the evaluation of small molecule:RNA triplex interactions that generate predictive models and will allow small molecule interrogation of the growing body of disease-associated RNA triple helices.

Published
2023

167. Factors Affecting Australian Catholics’ Return to Mass After COVID-19 Church Closures

Author

Philippa Martyr

Subjects
Surveys and Questionnaires, Australia, Catholicism, Religious studies, COVID-19, Humans, General Medicine, General Nursing
Abstract

In 2020, many places of worship closed due to COVID-19 restrictions, raising questions about rates of return to worship after COVID-19. This survey-based study of 806 Australian churchgoing Catholics explores relationships between a range of variables and the rate of return to Mass attendance after church closures. Pre-closure Mass attendance rate strongly and significantly predicted real-life worship during church closures and higher rates of return to Mass attendance after churches reopened. Real-life worship during COVID-19 also strongly predicted return to Mass attendance, and positively mediated the relationship between pre- and post-closure Mass attendance rates. Virtual worship engagement did not significantly predict return to Mass attendance, but positively mediated the relationship between pre- and post-closure Mass attendance rates, with a smaller effect size.

Published
2022
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169. Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies

Author

Mason, James Paul, primary, Werth, Alexandra, additional, West, Colin G., additional, Youngblood, Allison, additional, Woodraska, Donald L., additional, Peck, Courtney L., additional, Aradhya, Arvind J., additional, Cai, Yijian, additional, Chaparro, David, additional, Erikson, James W., additional, Ganesan, Koushik, additional, Geerdts, T. R., additional, Hoang, Thi D, additional, Horning, Thomas M., additional, Jin, Yan, additional, Liu, Haixin, additional, Lordi, Noah, additional, Luo, Zheng, additional, Menon, Thanmay S., additional, Meyer, Josephine C., additional, Nelson, Emma E, additional, Oliver, Kristin A., additional, Ramirez Ortiz, Jorge L, additional, Osborne, Andrew, additional, Patterson, Alyx, additional, Pellatz, Nick, additional, Pitten, John, additional, Shitara, Nanako, additional, Steckhahn, Daniel, additional, Visal, Aseem, additional, Wang, Hongda, additional, Wang, Chaoran, additional, Wickenden, Evan, additional, Wilson, John, additional, Wu, Mengyu, additional, Yegovtsev, Nikolay, additional, Zimmermann, Ingrid H, additional, Aaron, James Holland, additional, Abdullah, Jumana T., additional, Abrams, Jonathan M., additional, Abrashoff, Riley, additional, Acevedo, Andres B., additional, Acha, Iker, additional, Meza Acosta, Daniela M., additional, Adam, Megan M., additional, Adams, Dante Q., additional, Adams, Kalvyn N, additional, Adams, Elena R, additional, Akbar, Zainab A., additional, Akruwala, Ushmi H., additional, Al-Ghazwi, Adel, additional, Alabbas, Batool H., additional, Alawadhi, Areej A., additional, Alharbi, Yazeed A., additional, Alahmed, Mohammed S., additional, Albakr, Mohammed A., additional, Albalushi, Yusef J., additional, Albaum, Jonathan, additional, Aldhamen, Ahmed, additional, Ales, Nolan, additional, Alesmail, Mohammad, additional, Alhabeeb, Abdulelah, additional, Alhamli, Dania, additional, Alhuseini, Isehaq, additional, Alkaabi, Suhail, additional, Alkhezzi, Tameem, additional, Alkubaisi, Mohamed, additional, Allanqawi, Nasser, additional, Allsbrook, Martin, additional, Almohsen, Yousef A., additional, Almquist, Justin Thomas, additional, Alnaji, Teeb, additional, Alnasrallah, Yousef A, additional, Alonzi, Nicholas, additional, Alosaimi, Meshal, additional, Alqabani, Emeen, additional, Alrubaie, Mohammad, additional, Alsinan, Reema A., additional, Altenbern, Ava L., additional, Altokhais, Abdullah, additional, Alyami, Saleh A., additional, Ameijenda, Federico, additional, Amer, Hamzi, additional, Amos, Meggan, additional, Anderson, Hunter J., additional, Andrew, Carter, additional, Andringa, Jesse C, additional, Angwin, Abigail, additional, Van Anne, Gabreece, additional, Aramians, Andrew, additional, Arango, Camila Villamil, additional, Archibald, Jack. W., additional, Arias-Robles, Brian A., additional, Aryan, Maryam, additional, Ash, Kevin, additional, Astalos, Justin, additional, Atchley-Rivers, N. S., additional, Augenstein, Dakota N., additional, Austin, Bryce W., additional, Avula, Abhinav, additional, Aycock, Matthew C., additional, Baflah, Abdulrahman A., additional, Balaji, Sahana, additional, Balajonda, Brian, additional, Balcer, Leo M, additional, Baldwin, James O., additional, Banda, David J, additional, Bard, Titus, additional, Barmore, Abby, additional, Barnes, Grant M., additional, Barnhart, Logan D. W., additional, Barone, Kevin M., additional, Bartman, Jessica L., additional, Bassel, Claire, additional, Bastias, Catalina S, additional, Bat-Ulzii, Batchimeg, additional, Batra, Jasleen, additional, Battist, Lexi, additional, Bay, Joshua, additional, Beach, Simone, additional, Beard, Sara, additional, Beato, Quinn I, additional, Beattie, Ryan, additional, Beatty, Thomas, additional, De La Beaujardiere, Tristan, additional, Beauprez, Jacob N., additional, Beck, M. G., additional, Beck, Lily, additional, Becker, Simone E., additional, Behr, Braden, additional, Behrer, Timothy A., additional, Beijer, Joshua, additional, Belei, Brennan J., additional, Belknap, Annelene L., additional, Bell, Aislyn, additional, Bence, Caden, additional, Benke, Evan, additional, Berhanu, Naomi, additional, Berriman-Rozen, Zachary D., additional, Bertuccio, Chrisanna, additional, Berv, Owen A., additional, Biediger, Blaine B., additional, Biehle, Samuel J, additional, Billig, Brennen, additional, Billingsley, Jacob, additional, Billman, Jayce A., additional, Biron, Connor J., additional, Bisacca, Gabrielle E., additional, Blake, Cassidy A., additional, Blandon, Guillermo, additional, Blevins, Olivia, additional, Blouin, Ethan, additional, Bodzianowski, Michal, additional, Boeyink, Taylor A., additional, Bondar, Matthew, additional, Bone, Lauren, additional, De Los Monteros Bonilla, Alberto Espinosa, additional, Borelli, William T, additional, Borgerding, Luke R., additional, Bowen, Troy, additional, Boyer, Christine, additional, Boyer, Aidan, additional, Boyle, Aidan P., additional, Boyne, Tom, additional, Branch, Donovan, additional, Brecl, Ariana E., additional, Brennan, David J., additional, Brimhall, Alexander J, additional, Brockman, Jennifer L., additional, Brookins, Sarah, additional, Brown, Gabriel T., additional, Brown, Cameron L., additional, Brown, Ryan, additional, Brownlow, Jordi, additional, Brumage-Heller, Grant, additional, Brumley, Preston J., additional, Bryan, Samuel, additional, Brzostowicz, A., additional, Buhamad, Maryam, additional, Bullard-Connor, Gigi, additional, Bunsow, J. R. Ramirez, additional, Burns, Annemarie C., additional, Burritt, John J., additional, Burton, Nicholas David, additional, Burton, Taylor, additional, Busch, Celeste, additional, Butler, Dylan R., additional, Buxton, B. W., additional, C. Toups, Malena, additional, Cabbage, Carter C., additional, Cage, Breonna, additional, Cahn, Jackson R., additional, Campbell, Andrew J, additional, Canales, Braden P., additional, Cancio, Alejandro R., additional, Carey, Luke, additional, Carillion, Emma L., additional, Carpender, Michael Andrew, additional, Carpenter, Emily, additional, Chadda, Shivank, additional, Chambers, Paige, additional, Chanders, Jasey, additional, Chandler, Olivia M., additional, Chang, Ethan C., additional, Chapman, Mitchell G., additional, Chapman, Logan T., additional, Chavali, S., additional, Chavez, Luis, additional, Chen, Kevin, additional, Chen, Lily, additional, Chen, Sam, additional, Chen, Judy, additional, Chhetri, Jenisha, additional, Chiles, Bradyn, additional, Chizmar, Kayla M., additional, Christiansen, Katherine E, additional, Cisne, Nicholas A., additional, Cisneros, Alexis, additional, Clark, David B., additional, Clarke, Evelyn, additional, Clarkson, Peter C, additional, Clausi, Alexis R., additional, Cochran, Brooke, additional, Coe, Ryan W., additional, Coleman-Plante, Aislinn, additional, Colleran, Jake R., additional, Colleran, Zachary, additional, Collier, Curran, additional, Collins, Nathaniel A., additional, Collins, Sarah, additional, Collins, Jack C., additional, Colozzi, Michael, additional, Colter, Aurora, additional, Cone, Rebecca A., additional, Conroy, Thomas C., additional, Conti, Reese, additional, Contizano, Charles J., additional, Cool, Destiny J., additional, Cooper, Nicholas M., additional, Corbitt, Jessica S, additional, Courtney, Jonas, additional, Courtney, Olivia, additional, Cox, Corben L., additional, Craig, Wilmsen B., additional, Creany, Joshua B., additional, Crews, Anastasia, additional, Crocker, K. A., additional, Croteau, A. J., additional, Crow, Christian J., additional, Cruse, Zoe, additional, Cruz, Avril, additional, Curnow, Tyler L., additional, Current, Hayden, additional, Curry, Riley T., additional, Cutler, Libby, additional, Cyr, Aidan St., additional, Dabberdt, Frederick M., additional, Daboub, Johnston, additional, Damgaard, Olivia, additional, Das, Swagatam, additional, Davis, Emma A. B., additional, Debarros, Elyse, additional, Deel, Sean, additional, Delasantos, Megan E., additional, Deng, Tianyue, additional, Derwin, Zachary, additional, Desai, Om, additional, Dewey, Kai, additional, Dias, John S., additional, Dice, Kenzie A., additional, Dick, R., additional, Dicken, Cyrus A., additional, Dietrick, Henry, additional, Dinser, Alexis M., additional, Dixon, Alyssa M., additional, Dixon, Thomas J., additional, Do, Helen C., additional, Doan, Chris H, additional, Doane, Connor, additional, Dodrill, Joshua, additional, Doermer, Timothy, additional, Dominguez, Lizbeth Montoya, additional, Dominguez, J., additional, Domke, Emerson N., additional, Doran, Caroline R., additional, Dorr, Jackson A., additional, Dorricott, Philip, additional, Dresdner, Danielle C., additional, Driscoll, Michael, additional, Driscoll, Kailer H., additional, Duncan, Sheridan J., additional, Dunlap, Christian, additional, Dunn, Gabrielle M., additional, Duong, Tien Q., additional, Dupeyron, Tomi Oshima, additional, Dvorak, Peter, additional, East, Andrew, additional, East, Andrew N., additional, Edwards, Bree, additional, Ehrlich, Lauren, additional, Elbashir, Sara I., additional, Engelhardt, Rasce, additional, Engelstad, Jacob, additional, England, Colin, additional, Enrich, Andrew, additional, Erickson, Abbey, additional, Erickson, Benjamin, additional, Evans, Nathan, additional, Ewing, Calvin A, additional, Eyeson, Elizabeth A., additional, Faber, Ian, additional, Fails, Avery M., additional, Fauntleroy, John T, additional, Fell, Kevin, additional, Feng, Zitian, additional, Fenwick, Logan D., additional, Feoktistov, Nikita, additional, Fife, Ryann, additional, D. Figueirinhas, John Alfred, additional, Fisch, Jean-Paul, additional, Fischer, Emmalee, additional, Fischer-White, Jules, additional, Fitton, Aidan F., additional, Fix, Alexander, additional, Flackett, Lydia, additional, Flores, Fernando, additional, Floyd, Aidan, additional, Del Foco, Leonardo, additional, Folarin, Adeduni, additional, Forbes, Aidan E., additional, Fortino, Elise, additional, Fougere, Benjamin L., additional, Fowler, Alexandra A., additional, Fox, Margaret, additional, French, James M., additional, French, Katherine V., additional, Frick, Florian G., additional, Fuchs, Calvin R., additional, Fuhrman, Bethany E. S., additional, Furney, Sebastian, additional, Gabir, Moutamen, additional, Galarraga, Gabriela, additional, Gale, Skylar, additional, Gapin, Keala C., additional, Garscadden, A. J., additional, Gasser, Rachel, additional, Gayou, Lily, additional, Gearhart, Emily E., additional, Geisman, Jane, additional, Geneser, Julianne R., additional, Genne, Sl, additional, Gentile, Julia G, additional, Gentry, Eleanor, additional, George, Jacob D., additional, Georgiades, Nathaniel James, additional, Gerhardstein, Phillip, additional, Gersabeck, Clint, additional, Ghaith, Bandar Abu, additional, Ghiassi, Dorsa, additional, Giebner, B. C., additional, Gilmartin, Dalton, additional, Gilpatrick, Connor B., additional, Gjini, Michael, additional, Golden, Olivia, additional, Golding, Nathan T., additional, Goldsberry, C. A., additional, Gomez, Angel R., additional, Gomez, Angel A., additional, Gopalakrishnan, Sean, additional, Gopalani, Mariam, additional, Gotlib, Nicholas, additional, Graham, Alaina S., additional, Gray, Michael J, additional, Gregory, Alannah H., additional, Gregory, Joshua A., additional, Grell, Kristyn, additional, Griego, Justus, additional, Griffin, Nicholas F., additional, Griffin, Kyle J., additional, Guerrero, Matt, additional, Gunderson, Nicole, additional, Guo, Mutian, additional, Gustavsson, E. R., additional, Hach, Grace K., additional, Haile, L. N., additional, Haines, Jessica, additional, Mc Hale, Jack J., additional, Hales, Ryder Buchanan, additional, Haley, Mark S., additional, Hall, Jacqueline L., additional, Hamilton, Sean R., additional, Han, Soonhee, additional, Hand, Tyler, additional, Hanley, Luke C., additional, Hansen, Connor M, additional, Hansen, Joshua A., additional, Hansson, Jonathan, additional, Hao, Tony Yunfei, additional, Haratsaris, Nicholas, additional, Hardie, Isabelle, additional, Hardwick, Dillon F., additional, Hares, Cameron T., additional, Harris, Logan Swous, additional, Harris, Coyle M., additional, Hart, Omer, additional, Hashiro, Kyle, additional, Hattendorf, Elsie, additional, Haubrich, Calder, additional, Hawat, Elijah, additional, Hayrynen, Griffin A., additional, Heintz, Danielle A., additional, Hellweg, Tim, additional, Hernandez, Angel, additional, Herrera, Emanuel, additional, Herrington, Robert N., additional, Herwig, Tim, additional, Hesse, Troy M., additional, Hiatt, Quinn, additional, Hibbard, Lea Pearl, additional, Hicks, Imari R., additional, Hicks, Andrew J., additional, Highhouse, Nigel, additional, Hildebrand, Annalise K., additional, Hill, Paula, additional, Hill, Hallie, additional, Hintsa, Evan, additional, Hirschmann, Anna E., additional, Hitt, Travis, additional, Ho, Ella, additional, Hoff, Isabelle J., additional, Hoffman, Alex, additional, Hogen, Blake A., additional, Horne, Linda, additional, Houck, Timothy J, additional, Howell, Noah H., additional, Hrudka, E. M., additional, Hu, J., additional, Huang, Jianyang, additional, Huang, Chenqi, additional, Huang, Shancheng, additional, Hudson, Zachary A., additional, Hudson, Nathan C., additional, Huebsch, Tyler J., additional, Hull, Owen, additional, Hunter, Samuel C, additional, Husted, Troy, additional, Hutabarat, Abigail P., additional, Huynh, Leslie, additional, Samour Ii, Antonio E., additional, Idoine, Yolande, additional, Ingram, Julia A., additional, Iovan, Taro, additional, Isert, Samuel A., additional, Salcido-Alcontar, Antonio, additional, Jacobsen, Thomas, additional, Jaimes, Alan A, additional, Jameson, Connor, additional, Jarriel, J. R., additional, Jarvis, Sam, additional, Jenkins, Josh, additional, Jensen, Alexander V., additional, Jeong, Jacob, additional, Jeseritz, Luke A., additional, Jesse, Trevor, additional, Ji, Soo Yeun, additional, Jiang, Yufan, additional, Johnson, Owen, additional, Johnson, Matthew, additional, Johnson, Sawyer, additional, Johnston, Julia, additional, Johnston, Braedon Y., additional, Jones, Olivia M., additional, Jones, M. R., additional, Jourabchi, Tara, additional, House, Tony A., additional, Juels, Parker, additional, T. Kainz, Sabrina J. H., additional, Kaiser, Emily, additional, Kallemeyn, Nicolas Ian, additional, Kalmus, Madison H., additional, Kalra, Etash, additional, Kamenetskiy, Margaret, additional, Kanokthippayakun, Jeerakit, additional, Kapla, Shaun D., additional, Karsh, Brennan J., additional, Keating, Caden J., additional, Kelley, Morgan A., additional, Kelley, Michael P., additional, Kelly, Nicholas, additional, Kelly, James, additional, Kelly, Teagan, additional, Kelly, Christopher M, additional, Kennedy, Kellen, additional, Kennedy, Cayla J., additional, Kennedy, Forrest, additional, Kennedy, Abigail, additional, Kerr-Layton, Liana, additional, Ketterer, Marilyn, additional, Khan, Ibraheem A., additional, Khan, Usman, additional, Khanal, Sapriya, additional, Kiechlin, Jack L., additional, Killian, Dominic, additional, Kim, Kevin, additional, Kim, Brian T., additional, Kim, Matthew M., additional, Kim, Jake, additional, Kimlicko, Aspen, additional, Kipp, Isabel M, additional, Kirkpatrick, Hunter B., additional, Kissner, Natalie, additional, Kite, Emily R., additional, Kleinhaus, Olivia R., additional, Knott, Philip Whiting, additional, Koch, Will, additional, Koenig, Greta, additional, Koke, Emily, additional, Kokes, Thomas, additional, Kothamdi, Yash S., additional, Krajnak, Zack, additional, Kresek, Zoe M., additional, Kriegman, Dylan, additional, Kritzberg, Jake E., additional, Krueger, Davis J., additional, Kubiak, Bartlomiej, additional, Kuehl, Kirsten, additional, Kuester, Chrisanne, additional, Kuiper, Nicolas A., additional, Kumar, Aman Priyadarshi, additional, Kuybus, Connor, additional, Kwiatkowski, Daniel, additional, Lafemina, Quintin Y., additional, Lacjak, Kevin, additional, Lahmers, Kyle, additional, Lam, Antonia, additional, Landrey, Kalin, additional, Lantz, Maxwell B., additional, Larter, Zachary, additional, Lau, Benjamin P., additional, Lauzon, Megan, additional, Lawlor, Rian, additional, Learned, Tyler, additional, Lee, E. C., additional, Lee, Junwon, additional, Lee, Adrianna J., additional, Lee, Justin, additional, Lee, Alexis Ying-Shan, additional, Lee, Christian J, additional, Lee, Nathaniel F., additional, Leiker, Linzhi, additional, Lengerich, Dylan, additional, Leoni, Cecilia, additional, Lezak, Adrienne R., additional, Li, David Y., additional, Li, Isaac, additional, Liao, Ryan Z., additional, Linders, Bridget, additional, Linger, Morgan I, additional, Linnane, Katherine B., additional, Lippincott, Sam, additional, Lister, Barrett, additional, Litton, Shelby D, additional, Liu, Nianzi, additional, Liu, Steven Y., additional, Logan, Timothy W., additional, Londres, Nathan, additional, Lonergan, Mia C., additional, Lookhoff, Emily, additional, Loomis, N. E., additional, Lopez, Christian, additional, Loring, Justin, additional, Lucca, Jeffrey, additional, Lukianow, Dax, additional, M. Cheang, Nathan, additional, Macdonald, William, additional, Madonna, Claire A., additional, Madsen, Kasey O., additional, Maksimuk, Tiffany E., additional, Mallory, Macguire, additional, Malone, Ryan A., additional, Maly, Blake, additional, Manzanares, Xander R., additional, Maravi, Aimee S., additional, Marcus, Serafima M., additional, Marikar, Nasreen, additional, Marquez, Josie A., additional, Marquez, Mathew J., additional, Marsh, Lauren, additional, Marsh, Toni, additional, Martin, Logan S., additional, Martinez, Alexa M., additional, Martinez, Jose R., additional, Martinez, Hazelia K., additional, Martyr, Cara, additional, Masri, Mirna, additional, Matessi, Giorgio, additional, Khan Mohd Reduan Mathavan, Adam Izz, additional, Mathieson, Randi M., additional, Mathur, Kabir P., additional, Mauer, Graham, additional, Mayer, Victoria A., additional, Mazzotta, Liam, additional, Mccammon, Glen S., additional, Mcconvey, Rowan, additional, Mccormick, Tyler, additional, Mccoy, Andrew, additional, Mcentee, Kelleen, additional, Mcgarvey, Meaghan V., additional, Mcgill, Riley M., additional, Mcintyre, James K., additional, Mckemey, Finbar K., additional, Mcmorris, Zane, additional, Mcmullan, Jesse J., additional, Mcquaid, Ella, additional, Mcvey, Caden, additional, Mccurry, Kyle, additional, Medellin, Mateo M., additional, Medialdea, Melissa, additional, Mehidic, Amar, additional, Meillon, Stella, additional, Meiselman-Ashen, Jonah B., additional, Mellett, Sarah, additional, Menassa, Dominic, additional, Mendez, Citlali, additional, Mendoza-Anselmi, Patricia, additional, Menke, Riley, additional, Mesgina, Sarah, additional, Mewhirter, William J., additional, Meyer, Ethan, additional, Miften, Aya M., additional, Miles, Ethan J., additional, Miller, Andrew, additional, Miller, Joshua B., additional, Millican, Emily B., additional, Millican, Sarah J., additional, Mills, Dylan P., additional, Minimo, Josh, additional, Misener, Jay H., additional, Mitchell, Alexander J., additional, Mizzi, Alexander Z., additional, Molina-Saenz, Luis, additional, Moll, Tyler S, additional, Moll, Hayden, additional, Montano, Maximus, additional, Montoya, Michael, additional, Monyek, Eli, additional, Mora, Jacqueline Rodriguez, additional, Morales, Gavin, additional, Morales, Genaro, additional, Morelock, Annalise M., additional, Morency, Cora, additional, Moreno, Angel J., additional, Morgan, Remy, additional, Moss, Alexander P., additional, Muckenthaler, Brandon A., additional, Mueller, Alexander, additional, Mulcahy, Owen T., additional, Mundy, Aria T., additional, Muniz, Alexis A., additional, Murphy, Maxwell J., additional, Murphy, Madalyn C., additional, Murphy, Ryan C., additional, Murrel, Tyler, additional, Musgrave, Andrew J., additional, Myer, Michael S., additional, Nandu, Kshmya, additional, Napoletano, Elena R., additional, Naqi, Abdulaziz, additional, Narayan, Anoothi, additional, Nasser, Liebe, additional, Neeland, Brenna K, additional, Nehring, Molly, additional, Nelson, Maya Li, additional, Nguyen, Lena P., additional, Nguyen, Lena, additional, Nguyen, Leonardo, additional, Nguyen, Valerie A., additional, Nguyen, Khoa D, additional, Norden, Kelso, additional, Norris, Cooper, additional, Nunes-Valdes, Dario, additional, Nussbaum, Rosemary O., additional, O’Sullivan, Cian, additional, O’Neill, Ian, additional, Oakes, S. H., additional, Odbayar, Anand, additional, Ogle, Caleb, additional, Oishi-Holder, Sean, additional, Olguin, Nicholas, additional, Olson, Nathaniel P., additional, Ong, Jason, additional, Opp, Elena N., additional, Orbidan, Dan, additional, Oros, Ryan, additional, Ort, Althea E., additional, Osborn, Matthew, additional, Osogwin, Austin, additional, Otto, Grant, additional, Oudakker, Jessica, additional, Overchuk, Igor, additional, Padgette, Hannah M., additional, Padilla, Jacqueline, additional, Palizzi, Mallory, additional, Palmgren, Madeleine L., additional, Palos, Adler, additional, Pan, Luke J., additional, Parker, Nathan L., additional, Parker, Sasha R., additional, Parkinson, Evan J., additional, Parulekar, Anish, additional, Pastor, Paige J., additional, Patel, Kajal, additional, Patel, Akhil, additional, Patel, Neil S., additional, Patti, Samuel, additional, Patton, Catherine, additional, Payne, Genevieve K., additional, Payne, Matthew P., additional, Pearl, Harrison M., additional, Beck Von Peccoz, Charles B., additional, Pedersen, Alexander J., additional, Pelster, Lily M., additional, Peou, Munisettha E., additional, Perez, J. S., additional, Perez, Freddy, additional, Pesce, Anneliese, additional, Petersen, Audrey J., additional, Peterson, B., additional, Petric, Romeo S. L., additional, Pettine, Joshua, additional, Phalen, Ethan J., additional, Pham, Alexander V., additional, Phan, Denise M., additional, Pherigo, Callie C, additional, Phillips, Lance, additional, Phillips, Justin, additional, Phommatha, Krista, additional, Pietras, Alex, additional, Pine, Tawanchai P., additional, Pitsuean-Meier, Sedique, additional, Pixley, Andrew M., additional, Plantz, Will, additional, Plummer, William C., additional, Plutt, Kaitlyn E., additional, Plzak, Audrey E., additional, Pohle, Kyle, additional, Polikoff, Hyden, additional, Pollard, Matthew, additional, Polly, Madelyn, additional, Porter, Trevor J., additional, Price, David, additional, Price, Nicholas K., additional, Prinster, Gale H., additional, Propper, Henry Austin, additional, Quarderer, Josh, additional, Quinn, Megan S., additional, Quinonez, Oliver, additional, Quispe, Devon, additional, Ragsdale, Cameron, additional, Rahn, Anna L., additional, Rakhmonova, M., additional, Ralapanawe, Anoush K, additional, Ramachandra, Nidhi, additional, Ramirez, Nathaniel, additional, Ramirez, Ariana C., additional, Ramirez, Sacha, additional, Randolph, Parker, additional, Ranjan, Anurag, additional, Rankin, Frederick C, additional, Rapaport, Sarah Grace, additional, Ratajczyk, Nicholas O, additional, Ray, Mia G. V., additional, Reagan, Brian D., additional, Recchia, John C., additional, Reddy, Brooklyn J., additional, Reed, Joseph, additional, Reed, Charlie, additional, Reeves, Justin, additional, Reh, Eileen N., additional, Von Reich, Ferin J., additional, Reyna, Andrea B., additional, Reynolds, Alexander, additional, Reynolds, Hope, additional, Rippel, Matthew, additional, Rivas, Guillermo A., additional, Rives, Anna Linnea, additional, Robert, Amanda M., additional, Robertson, Samuel M., additional, Rodgers, Maeve, additional, Rojec, Stewart, additional, Romero, Andres C., additional, Rosasco, Ryan, additional, Rossman, Beth, additional, Rotter, Michael, additional, Rounsefell, Tyndall, additional, Rouse, Charlotte, additional, Routledge, Allie C., additional, Roy, Marc G., additional, Roy, Zoe A., additional, Ruger, Ryan, additional, Ruggles-Delgado, Kendall, additional, Rule, Ian C., additional, Rumley, Madigan, additional, Runyon, Brenton M., additional, Ruprecht, Collin, additional, Russell, Bowman, additional, Russell, Sloan, additional, Ryder, Diana, additional, Saeb, David, additional, Salazar, J., additional, Salazar, Violeta, additional, Saldi, Maxwell, additional, Salgado, Jose A., additional, Salindeho, Adam D., additional, Sanchez, Ethan S., additional, Sanchez-Sanchez, Gustavo, additional, Sarfaraz, Darian, additional, Sarkar, Sucheta, additional, Sato, Ginn A., additional, Savage, Carl, additional, Schaller, Marcus T., additional, Scheck, Benjamin T., additional, Schlenker, Jared A. W., additional, Schofer, Matthew J, additional, Schubert, Stephanie H., additional, Schultze, Courtney, additional, Schumacher, Grace K, additional, Seglem, Kasper, additional, Serio, Lauren, additional, Seux, Octave, additional, Shahba, Hannan, additional, Shannahan, Callie D., additional, Sharma, Shajesh, additional, Shaver, Nathan, additional, Shaw, Timothy, additional, Shelby, Arlee K., additional, Shelby, Emma, additional, Shelchuk, Grace, additional, Sheldrake, Tucker, additional, Sherry, Daniel P., additional, Shi, Kyle Z., additional, Shields, Amanda M., additional, Shin, Kyungeun, additional, Shockley, Michael C., additional, Shoha, Dominick, additional, Shortman, Jadon, additional, Shuttleworth, Mitchell, additional, Sibrell, Lisa, additional, Sickler, Molly G., additional, Siles, Nathan, additional, Silvester, H. K., additional, Simmons, Conor, additional, Simone, Dylan M., additional, Simone, Anna, additional, Singh, Savi, additional, Singh, Maya A., additional, Sinkovic, Madeline, additional, Sipowicz, Leo, additional, Sjoroos, Chris, additional, Slocum, Ryan, additional, Slyne, Colin, additional, Smart, Korben, additional, Smith, Alexandra N., additional, Smith, Kelly, additional, Smith, Corey, additional, Smith, Elena K., additional, Smith, Samantha M., additional, Smith, Percy, additional, Smith, Trevor J, additional, Snyder, G. L., additional, Soby, Daniel A., additional, Sohail, Arman S., additional, Solorio, William J., additional, Solt, Lincoln, additional, Soon, Caitlin, additional, Spangler, Ava A, additional, Spicer, Benjamin C., additional, Srivastava, Ashish, additional, Stamos, Emily, additional, Starbuck, Peter, additional, Stark, Ethan K., additional, Starling, Travis, additional, Staudenmier, Caitlyn, additional, Steinbarth, Sheen L., additional, Steinsberger, Christopher H., additional, Stepaniak, Tyler, additional, Steward, Ellie N., additional, Stewart, Trey, additional, Stewart, T. C., additional, Stratmeyer, Cooper N., additional, Stratton, Grant L., additional, Stribling, Jordin L., additional, Sulaiman, S. A, additional, Sullivan, Brandon J, additional, Sundell, M. E., additional, Sur, Sohan N., additional, Suri, Rohan, additional, Swartz, Jason R., additional, Sweeney, Joshua D., additional, Syed, Konner, additional, Szabo, Emi, additional, Szeremeta, Philip, additional, Ta, Michael-Tan D., additional, Tanguma, Nolan C., additional, Taulman, Kyle, additional, Taylor, Nicole, additional, Taylor, Eleanor, additional, Taylor, Liam C., additional, Tayman, K. E., additional, Tellez, Yesica, additional, Terrile, Richard, additional, Tesdahl, Corey D, additional, Thielmann, Quinn N., additional, Thoman, Gerig, additional, Thomas, Daniel, additional, Thomas, Jeffrey J., additional, Thompson, William N., additional, Thornally, Noah R., additional, Tobin, Darien P., additional, Ton, Kelly, additional, Toon, Nathaniel J., additional, Tran, Kevin, additional, Tran, Bryn, additional, Trank-Greene, Maedee, additional, Trautwein, Emily D., additional, Traxler, Robert B., additional, Tressler, Judah, additional, Trofino, Tyson R., additional, Troisi, Thomas, additional, Trunko, Benjamin L., additional, Truong, Joshua K., additional, Tucker, Julia, additional, Umbricht, Thomas D, additional, Uphoff, C. H., additional, Upthegrove, Zachary T., additional, Vadayar, Shreenija, additional, Valencia, Whitney, additional, Vallery, Mia M., additional, Vanetten, Eleanor, additional, Vann, John D., additional, Varela, Ilian, additional, Vassilyev, Alexandr, additional, Vaver, Nicholas J., additional, Velamala, Anjali A., additional, Vendetti, Evan, additional, Venegas, Nancy Ortiz, additional, Vepa, Aditya V., additional, Vess, Marcus T., additional, Veta, Jenna S., additional, Victory, Andrew, additional, Vinson, Jessica, additional, Vogel, Connor Maklain, additional, Wagoner, Michaela, additional, Wallace, Steven P., additional, Wallace, Logan, additional, Waller, Caroline, additional, Wang, Jiawei, additional, Warble, Keenan, additional, Ward-Chene, N. R. D., additional, Watson, James Adam, additional, Weber, Robert J., additional, Wegner, Aidan B., additional, Weigand, Anthony A, additional, Weiner, Amanda M., additional, West, Ayana, additional, Wexler, Ethan Benjamin, additional, Wheeler, Nicola H., additional, White, Jamison R., additional, White, Zachary, additional, White, Oliver S., additional, Whittall, Lloyd C., additional, Wilcove, Isaac, additional, Wilkinson, Blake C., additional, Willard, John S., additional, Williams, Abigail K., additional, Williams, Sajan, additional, Wilson, Orion K., additional, Wilson, Evan M., additional, Wilson, Timothy R., additional, Wilson, Connor B., additional, Witkoff, Briahn, additional, Wolfe, Aubrey M., additional, Wolle, Jackson R., additional, Wood, Travis M., additional, Woodard, Aiden L., additional, Wootten, Katelynn, additional, Xiao, Catherine, additional, Yang, Jianing, additional, Yang, Zhanchao, additional, Young, Trenton J., additional, Young, Isabel, additional, Zenner, Thomas, additional, Zhang, Jiaqi, additional, Zhao, Tianwei, additional, Zhao, Tiannie, additional, Zhao, Noah Y., additional, Zhou, Chongrui, additional, Ziebold, Josh J, additional, Ziegler, Lucas J., additional, Zygmunt, James C., additional, Zhang, Jinhua, additional, and Lewandowski, H. J., additional

Published
2023
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174. The 3rd version of the Climate Vulnerability Monitor: a free online tool providing globally comparable biophysical, macroeconomic and health climate impact information at the national level

Author

René Rott, Tabea Lissner, Rosanne Martyr-Koller, Fahad Saeed, and Bernd Hezel

Abstract

The 3rd version of the Climate Vulnerability Monitor (CVM3) is an independent global assessment of the impacts of climate change in the 21st century developed by a scientific consortium for the Climate Vulnerability Forum. It presents specific estimated climate change–attributable impact data that is internationally comparable in 32 biophysical, human health and economic indicators for most countries and all world regions. Based on the latest scenarios developed for the IPCC’s Sixth Assessment Report, the CVM3 assesses impacts for three scenarios (1.5°C scenario, a below 2°C scenario and a “no climate action” scenario) and three time slices (near-term (2030– mid-point year for 2021–2040), medium (2050) and end of the century (2090)).The free online tool “CVM Data Explorer” draws on information, data and results of the different work packages made available by the partners through three respective application programming interfaces (APIs). While the health data explorer shows potential changes in climate-related health risks, the economics data explorer illustrates the extent to which climate change is projected to alter macroeconomic indicators. The biophysical explorer presents estimate changes in indicators like near-surface air temperature and precipitation, offers an overview of present attributable impacts as well as covering current and future vulnerability of over 180 countries. based on the given emission scenarios. The tool displays these results of current and projected impacts with maps for the different pathways and timeframes and the underlying data is freely available for download.A multimedia part (“scrolly-telling”) of the tool takes a narrative-explorative approach to the results using different types of media such as video interviews, animations and interactive elements with local experts. These impact stories for five chosen countries (Bangladesh, Ghana, Kenya, Philippines, St. Lucia) aim to bring global databases together with regional to local impact and vulnerability information and showcase the CVM3 results in a narrative, concrete and exemplary manner.

Published
2023
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175. Australian Catholics’ Lived Experiences of COVID-19 Church Closures

Author

Philippa Martyr

Subjects
Religious studies, General Medicine, General Nursing
Abstract

In 2020, Australian Catholic churches closed due to COVID-19 restrictions, but there has been little qualitative data published on the lived experience of churchgoing Catholics in this period. Data from 175 Australian churchgoing Catholic survey participants who left responses describing their COVID-19 worship experiences as part of a larger project revealed five major themes: ‘Church and State’, ‘Blessings in disguise’, ‘Polarisation’, ‘Future proofing’, and ‘Loss’. Respondents expressed a diverse range of views about the church leadership, lockdowns, conspiracy theories, the merits and deficits of online worship, and their own thriving or suffering during church closures.

Published
2023
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176. Moringa and Graphite as Additives to Conventional Petroleum-Based Lubricants

Author

Nadiège Nomède-Martyr, Philippe Bilas, Yves Bercion, and Philippe Thomas

Subjects
vegetable oil, graphite, additive, mixed lubrication, Science
Abstract

Many researches are focused on the tribological performances of pure vegetable oil in order to replace the conventional mineral engine oils. This work investigates the influence of local moringa oil (noted VO) on the performances of lubricants formed from a blend of dodecane and graphite particles at ambient temperature. In a first part, a reduction of about 50% of friction properties of dodecane is observed when adding small amounts of moringa oil (VO), which is intended to be used as a bio-base performance additive in lubricant formulations. The friction properties of their blends with graphite, generally employed as solid lubricant additive, showed an adsorption effect of fatty acid molecules. The more promising results were obtained for the blend containing 2 w% of VO. Physicochemical characterizations of the tribofilms evidence the good antiwear properties of the lubricant.

Published
2021
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179. Psychological processes in adapting to dementia: Illness representations among the IDEAL cohort

Author

Linda Clare, Laura D. Gamble, Anthony Martyr, Catherine Quinn, Rachael Litherland, Robin G. Morris, Ian R. Jones, and Fiona E. Matthews

Subjects
Cohort Studies, Aging, Cross-Sectional Studies, Social Psychology, mental disorders, Adaptation, Psychological, Humans, Dementia, Geriatrics and Gerontology
Abstract

How people understand and adapt to living with dementia may influence well-being. Leventhal's Common Sense Model (CSM) of Self-Regulation provides a theoretical basis for exploring this process. We used cross-sectional and longitudinal data from 1,109 people with mild-to-moderate dementia in the Improving the experience of Dementia and Enhancing Active Life (IDEAL) cohort. We elicited dementia representations (DRs) using the Representations and Adjustment to Dementia Index (RADIX), a validated measure based on the CSM, identified groups sharing distinct DR profiles, and explored predictors of group membership and associations with well-being, and whether problem-focused coping played a mediating role in these associations. We identified four DR classes: people who see the condition as a disease and adopt a diagnostic label; people who see the condition as a disease but refer to symptoms rather than a diagnostic label; those who see the condition as part of aging; and those who are unsure how to make sense of the condition. A fifth group did not acknowledge any difficulties. "Disease" representations were associated with better cognition and younger age, while "aging" and "no problem" representations were associated with better mood and well-being. The association with well-being remained stable over 24 months. There was limited partial support for a mediating role of problem-focused coping. Variations in DRs may reflect individual differences in the psychological processes involved in adjusting to dementia. DRs provide a framework for personalizing and tailoring both communications about dementia and interventions aimed at supporting people in coping with dementia. There is a need to debate what constitutes a positive DR and how its development might be encouraged. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Published
2022
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181. A novel chimeric dengue vaccine candidate composed of consensus envelope protein domain III fused to C-terminal-modified NS1 protein

Author

Hong-Jyun Huang, Martyr Yang, Hsin-Wei Chen, Shuying Wang, Chih-Peng Chang, Tzong-Shiann Ho, Yu-San Kao, Sen-Mao Tien, Hsing-Han Lin, Po-Chun Chang, Yen-Chung Lai, Yu-Peng Hsiao, Yi-Ling Liu, Chiao-Hsuan Chao, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin, and Shu-Wen Wan

Subjects
Mice, Inbred C3H, Consensus, General Veterinary, General Immunology and Microbiology, Public Health, Environmental and Occupational Health, Endothelial Cells, Dengue Vaccines, Dengue Virus, Viral Nonstructural Proteins, Antibodies, Viral, Dengue, Mice, Infectious Diseases, Protein Domains, Viral Envelope Proteins, Animals, Molecular Medicine
Abstract

There is an urgent need for a safe and effective vaccine against dengue virus (DENV) which infects about 390 million humans per year. In the present study we combined modifications of two DENV proteins, the nonstructural protein 1 (NS1) and the envelope (E) protein, to produce a DENV vaccine candidate with enhanced features. One of these modified proteins was a C-terminal-deleted fragment of NS1 called ΔC NS1 which we have shown previously to be protective without the potentially harmful effects of cross-reactive epitopes common to surface antigens on platelets and endothelial cells. The other modified protein was an envelope protein domain III (cEDIII) containing a consensus amino acid sequence among the four serotypes of DENV, which induces neutralizing antibody against all four DENV serotypes. The cEDIII and ΔC NS1 were expressed as a fusion protein cEDIII-ΔC NS1 and its protective effects against DENV were evaluated in a mouse model. C3H/HeN mice were immunized three times with cEDIII-ΔC NS1 fusion protein mixed with alum as adjuvant. Sera collected from cEDIII-ΔC NS1-immunized mice neutralized four serotypes of DENV and also caused complement-mediated cytolysis of HMEC-1 cells infected with each of the four different DENV serotypes. Mice immunized with cEDIII-ΔC NS1 and challenged with DENV showed reduced serum virus titer, soluble NS1 and bleeding time, compared with mice infected with DENV alone. The results reveal that antibodies induced by cEDIII-ΔC NS1 not only show anti-viral efficacy by in vitro assays but also provide protective effects against DENV infection in a mouse model. The cEDIII-ΔC NS1 thus represents a novel, effective DENV vaccine candidate.

Published
2022
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182. Select Bibliography

Author

Justin Martyr, Saint, Slusser, Michael, Falls, Thomas B., and Halton, Thomas P.

Published
2012

183. Conclusion

Author

Justin Martyr, Saint, Slusser, Michael, Falls, Thomas B., and Halton, Thomas P.

Published
2012

186. Index of Holy Scripture

Author

Justin Martyr, Saint, Slusser, Michael, Falls, Thomas B., and Halton, Thomas P.

Published
2012

187. Jesus as high priest

Author

Justin Martyr, Saint, Slusser, Michael, Falls, Thomas B., and Halton, Thomas P.

Published
2012

188. The sign of Jonah

Author

Justin Martyr, Saint, Slusser, Michael, Falls, Thomas B., and Halton, Thomas P.

Published
2012

190. General Index

Author

Justin Martyr, Saint, Slusser, Michael, Falls, Thomas B., and Halton, Thomas P.

Published
2012

191. A final appeal

Author

Justin Martyr, Saint, Slusser, Michael, Falls, Thomas B., and Halton, Thomas P.

Published
2012

197. Divisions among Christians

Author

Justin Martyr, Saint, Slusser, Michael, Falls, Thomas B., and Halton, Thomas P.

Published
2012

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