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179. Plasma levels of n-3 fatty acids in bipolar patients: deficit restricted to DHA

Author

Pomponi, M, Janiri, L, La Torre, G, Di Stasio, Enrico, Di Nicola, M, Mazza, M, Martinotti, G, Bria, P, Lippa, S, Natili, R, Pomponi, Mfl, Di Stasio, Enrico (ORCID:0000-0003-1047-4261), Pomponi, M, Janiri, L, La Torre, G, Di Stasio, Enrico, Di Nicola, M, Mazza, M, Martinotti, G, Bria, P, Lippa, S, Natili, R, Pomponi, Mfl, and Di Stasio, Enrico (ORCID:0000-0003-1047-4261)

Abstract

Epidemiological studies suggest that n-3 polyunsaturated fatty acid (n-3 FA) deficiency is a risk factor for bipolar disorders (BDs). The aim of this study was to determine whether such a deficit does exist in patients with BD and to characterize the overall plasma fatty acid (FA) profile in these patients. Using gas chromatography/mass spectrometry, we measured fasting plasma levels of 15 FAs in 42 patients diagnosed with BD according to DSM-IV criteria and in 57 age- and gender-matched healthy controls. Plasma docosahexaenoic acid (DHA) levels were significantly decreased in bipolar patients (p < 0.001 versus healthy controls). Compared with controls, patients had higher plasma levels of all other FAs, including arachidonic acid (AA, p < 0.001), alpha-linolenic acid (ALA, p < 0.001), and eicosapentaenoic acid (EPA) (p < 0.001). Although in the present study we observed significant DHA deficits in the plasma of bipolar patients our findings do not support the therapeutic use of ALA and/or EPA supplementation. DHA may provide a basis for possible pharmacological intervention in psychiatric disorders at the level of second messengers linked to the phosphatidylinositol cycle. Finally, measurement of FA levels in plasma seems to be more reliable and reproducible than assays of erythrocyte FA content.

Published
2013

183. Reduced hedonic capacity in euthymic bipolar subjects: A trait-like feature?

Author

Di Nicola, Marco, De Risio, Luisa, Battaglia, Claudia, Camardese, Giovanni (ORCID:0000-0002-8139-9230), Tedeschi, Daniela, Mazza, M, Martinotti, G, Pozzi, Gino (ORCID:0000-0001-5227-7974), Niolu, C, Di Giannantonio, M, Siracusano, A, Janiri, Luigi (ORCID:0000-0002-1633-9418), Di Nicola, Marco, De Risio, Luisa, Battaglia, Claudia, Camardese, Giovanni (ORCID:0000-0002-8139-9230), Tedeschi, Daniela, Mazza, M, Martinotti, G, Pozzi, Gino (ORCID:0000-0001-5227-7974), Niolu, C, Di Giannantonio, M, Siracusano, A, and Janiri, Luigi (ORCID:0000-0002-1633-9418)

Abstract

BACKGROUND: The aim of our study was to assess hedonic capacity in euthymic bipolar subjects, identifying possible differences compared to remitted unipolar depressed patients and healthy controls. METHODS: 107 subjects with bipolar disorders, 86 with major depressive disorder and 106 healthy controls, homogeneous with respect to demographic characteristics, were enrolled. The following scales were administered: the Snaith-Hamilton pleasure scale (SHAPS), the subscale for 'anhedonia/asociality' of the scale for the assessment of negative symptoms (SANS) and the visual analogue scale (VAS) for hedonic capacity. RESULTS: Scores on SHAPS total, interests and social interactions, SANS 'anhedonia/asociality' and VAS were all significantly higher in affective disorder patients compared to healthy controls. No difference was found between clinical groups. 20.5% (n=22) of bipolar disorder subjects and 24.5% (n=21) of major depressed subjects showed a significant reduction in hedonic capacity (SHAPS total score ≥3), compared to 7.5% (n=8) of healthy controls (χ(2)=12.03; p=.002). LIMITATIONS: Limitations include heterogeneity with respect to pharmacological status and longitudinal course (i.e., 'single' vs. 'recurrent' affective episodes). CONCLUSIONS: The major finding of our study is that euthymic bipolar patients and remitted major depressed patients display residual anhedonic symptoms. This suggests that, in affective disorder patients, altered hedonic capacity could represent an enduring trait and that, possibly, dysfunctions in the neurobiological mechanisms underlying hedonic response and reward processing persist, irrespective of mood state.

Published
2012

184. Milano, Cecilia e l'agricoltura periurbana milanese

Author

Cagnoni, U, Martinotti, G, Forbici, S, Mela, A, Piselli, F, Amendola, G, Pieretti, G, Calvosa, F, Gilli, M, Marra, E, Borelli, G, Meloni, B, Cavalli, A, Pieroni, O, Nuvolati, G, Beato, F, Bocchi, S, Ferretto, M, Sorlini, C, FERRETTO, MATILDE, MARRA, EZIO, Cagnoni, U, Martinotti, G, Forbici, S, Mela, A, Piselli, F, Amendola, G, Pieretti, G, Calvosa, F, Gilli, M, Marra, E, Borelli, G, Meloni, B, Cavalli, A, Pieroni, O, Nuvolati, G, Beato, F, Bocchi, S, Ferretto, M, Sorlini, C, FERRETTO, MATILDE, and MARRA, EZIO

Published
2012

187. Com'è bella la città. Orizzonti immaginari dell’esistenza nelle società contemporanee

Author

Barenghi M, Langhella G., Turchetta M, Ferraris D, Paccagnini E, Baldi G, Saccone A, Maxia S, Martignoni C, Turi N, Westphal B, Basilico G, Consonni G, Matera V, Martinotti G, Matera, V, MATERA, VINCENZO, Barenghi M, Langhella G., Turchetta M, Ferraris D, Paccagnini E, Baldi G, Saccone A, Maxia S, Martignoni C, Turi N, Westphal B, Basilico G, Consonni G, Matera V, Martinotti G, Matera, V, and MATERA, VINCENZO

Published
2012

188. Tossicodipendenze, comorbilità e 'doppia diagnosi'

Author

Bellio, G, Bonfà, F, Carra', G, Diana, M, Di Giannantonio, M, Janiri, L, Mammana, G, Martinotti, G, Sanza, M, Scioli, R, Spinetti, G, Spinetti, G., CARRA', GIUSEPPE, Bellio, G, Bonfà, F, Carra', G, Diana, M, Di Giannantonio, M, Janiri, L, Mammana, G, Martinotti, G, Sanza, M, Scioli, R, Spinetti, G, Spinetti, G., and CARRA', GIUSEPPE

Published
2012

189. [Effect of diazepam on mitochondrial respiration]

Author

DI JESO F, TRUSCELLO A, MARTINOTTI G, MAGNANI B, MARTINOTTI A., DI JESO, Bruno, DI JESO, F, Truscello, A, Martinotti, G, DI JESO, Bruno, Magnani, B, and Martinotti, A.

Published
1990

196. Il mobile entertainment learning

Author

MARTINOTTI, G, DIAMANTINI, D, POZZALI, A, Pieri, M, PIERI, MICHELLE, MARTINOTTI, G, DIAMANTINI, D, POZZALI, A, Pieri, M, and PIERI, MICHELLE

Published
2008

198. Water, Man, the Desert

Author

Martinotti, G., Fabietti, U, FABIETTI, UGO ENZO MAURO, Martinotti, G., Fabietti, U, and FABIETTI, UGO ENZO MAURO

Published
2008

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