273 results on '"Martín, Ana P."'
Search Results
152. Long-term Clinical Outcomes of a Spanish Cohort of Metastatic Renal Cell Carcinoma Patients with a Complete Response to Sunitinib
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de Velasco, Guillermo, Alonso-Gordoa, Teresa, Rodríguez-Vida, Alejo, Anguera, Georgia, Campayo, Marc, Pinto, Álvaro, Ortega, Esther Martínez, Gallardo, Enrique, Núñez, Natalia Fernández, García-Carbonero, Iciar, Reig, Oscar, Méndez-Vidal, María José, Fernández-Calvo, Ovidio, Cassinello, Natalia Vidal, Torregrosa, Dolores, López-Martín, Ana, Rosero, Adriana, Valiente, Patricia G., de España, Carmen Garcías, Climent, Miguel A., Santasusana, Montserrat Domenech, Sánchez, Ángel Rodríguez, González, Isabel Chirivella, Afonso, Ruth, García del Muro, Xavier, Casinello, Javier, Fernández-Parra, Eva M., García Sánchez, Lourdes, Afonso, Javier, Polo, Susana Hernando, and Asensio, Úrsula
- Abstract
The long-term clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) and a complete response (CR) to the tyrosine kinase inhibitor (TKI) sunitinib are poorly known. The characteristics of these patients could reveal previously undetected associations with clinical variables.
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- 2023
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153. Acinetobacter baumanniiin critically ill patients: Molecular epidemiology, clinical features and predictors of mortality
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Garnacho-Montero, José, Gutiérrez-Pizarraya, Antonio, Díaz-Martín, Ana, Cisneros-Herreros, José Miguel, Cano, María Eugenia, Gato, Eva, Ruiz de Alegría, Carlos, Fernández-Cuenca, Felipe, Vila, Jordi, Martínez-Martínez, Luis, Tomás-Carmona, M. del Mar, Pascual, Álvaro, Bou, Germán, Pachón-Diaz, Jerónimo, and Rodríguez-Baño, Jesús
- Abstract
The main aim of this study was to assess changes in the epidemiology and clinical presentation of Acinetobacter baumanniiover a 10-year period, as well as risk factors of mortality in infected patients.
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- 2016
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154. Cancer suicide gene therapy: a patent review
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Navarro, Saúl Abenhamar, Carrillo, Esmeralda, Griñán-Lisón, Carmen, Martín, Ana, Perán, Macarena, Marchal, Juan Antonio, and Boulaiz, Houria
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ABSTRACTIntroduction: Cancer is considered the second leading cause of death worldwide despite the progress made in early detection and advances in classical therapies. Advancing in the fight against cancer requires the development of novel strategies, and the suicide gene transfer to tumor cells is providing new possibilities for cancer therapy.Areas covered: In this manuscript, authors present an overview of suicide gene systems and the latest innovations done to enhance cancer suicide gene therapy strategies by i) improving vectors for targeted gene delivery using tissue specific promoter and receptors; ii) modification of the tropism; and iii) combining suicide genes and/or classical therapies for cancer. Finally, the authors highlight the main challenges to be addressed in the future.Expert opinion: Even if many efforts are needed for suicide gene therapy to be a real alternative for cancer treatment, we believe that the significant progress made in the knowledge of cancer biology and characterization of cancer stem cells accompanied by the development of novel targeted vectors will enhance the effectiveness of this type of therapeutic strategy. Moreover, combined with current treatments, suicide gene therapy will improve the clinical outcome of patients with cancer in the future.
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- 2016
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155. Encefalitis de tronco de Bickerstaff atípica: 2 casos pediátricos
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Campos Segovia, Ana, Villena, Ana Pérez, Luján Martínez, Jorge, Zorzo Sánchez, Cristina, Blanco Martín, Ana Belén, Fernández Aurrecoechea, Javier, Montilla Izquierdo, Sonia, and Jiménez Martínez, José
- Abstract
La encefalitis de tronco de Bickerstaff (EB) es una enfermedad autoinmune rara que afecta a estructuras de sistema nervioso central. Se caracteriza por la presencia de ataxia, alteración del sensorio y oftalmoplejía. Se han descrito casos con presentación atípica.
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- 2016
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156. La agricultura social en Catalunya: innovación social y dinamización agroecológica para la ocupación de personas en riesgo de exclusión.
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González, Carleó Guirado, Perpinyá, Anna Badia, i Pujol, Antoni Francesc Tulla, and Martín, Ana Vera
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Copyright of Ager: Journal of Depopulation & Rural Development Studies / Revista de Estudios sobre Despoblación y Desarrollo Rural is the property of Rolde de Estudios Aragoneses and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2014
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157. Evaluación de la comprensión lectora en alumnos bilingües mazigio-español al término de la Educación Primaria.
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Rico-Martín, Ana M. and Mohamedi-Amaruch, Amaruch
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Copyright of Calidoscópio is the property of Universidade do Vale do Rio dos Sinos and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2014
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158. Caracterización del síndrome de tako-tsuboen España: resultados del registro nacional RETAKO
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Núñez Gil, Iván J., Andrés, Mireia, Almendro Delia, Manuel, Sionis, Alessandro, Martín, Ana, Bastante, Teresa, Córdoba Soriano, Juan Gabriel, Linares Vicente, José A., González Sucarrats, Silvia, and Sánchez-Grande Flecha, Alejandro
- Abstract
El síndrome de tako-tsuboes una entidad de etiología y epidemiología inciertas, capaz de semejarse a un infarto y que, aunque suele tener buen pronóstico, no está exenta de complicaciones. El objetivo del presente trabajo es caracterizar esta enfermedad en nuestro medio a través de un registro (REgistro nacional multicéntrico sobre síndome de TAKOtsubo).
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- 2015
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159. The Teaching of Politeness in the Spanish-as-a-foreign-language (SFL) Classroom
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Ramos-González, Noelia M. and Rico-Martín, Ana M.
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This work takes its starting point in the importance of appropriately incorporating politeness into the teaching of any foreign language so as to educate speakers to be capable of maintaining an effective interaction with its native speakers. With this aim, we examine the treatment of communicative politeness in SFL teaching manuals and in particular in two key documents from this teaching field: the Common European Framework of Reference for Languagesand the Cervantes Institute Curriculum. In the second part, methodological guidance is offered for teaching politeness in a reflexive way in the SFL classroom.
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- 2015
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160. 4th Pediatric Allergy and Asthma Meeting (PAAM)
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Yavuz, S. Tolga, Koc, Ozan, Gungor, Ali, Gok, Faysal, Hawley, Jessica, O’Brien, Christopher, Thomas, Matthew, Brodlie, Malcolm, Michaelis, Louise, Mota, Inês, Gaspar, Ângela, Piedade, Susana, Sampaio, Graça, Dias, José Geraldo, Paiva, Miguel, Morais-Almeida, Mário, Madureira, Cristina, Lopes, Tânia, Lopes, Susana, Almeida, Filipa, Sequeira, Alexandra, Carvalho, Fernanda, Oliveira, José, Gay-Crosier, Fabienne, Nenciu, Ioana-Valentina, Nita, Andreia Florina, Ulmeanu, Alexandru, Oraseanu, Dumitru, Zapucioiu, Carmen, Machinena, Adrianna, Sánchez, Olga Domínguez, Lozano, Montserrat Alvaro, Feijoo, Rosa Jiménez, Blasco, Jaime Lozano, Gibert, Mònica Piquer, Muñoz, Mª Teresa Giner, da Costa, Marcia Dias, Martín, Ana Maria Plaza, Yilmaz, Ebru Arik, Cavkaytar, Özlem, Buyuktiryaki, Betul, Soyer, Ozge, Sackesen, Cansin, Netting, Merryn, El-Merhibi, Adaweyah, Gold, Michael, Quinn, Patrick, Penttila, Irmeli, Makrides, Maria, Giavi, Stavroula, Muraro, Antonella, Lauener, Roger, Mercenier, Annick, Bersuch, Eugen, Montagner, Isabella M., Passioti, Maria, Celegato, Nicolò, Summermatter, Selina, Nutten, Sophie, Bourdeau, Tristan, Vissers, Yvonne M., Papadopoulos, Nikolaos G., van der Kleij, Hanneke, Warmenhoven, Hans, van Ree, Ronald, Pieters, Raymond, Opstelten, Dirk Jan, van Schijndel, Hans, Smit, Joost, Fitzsimons, Roisin, Timms, Victoria, Du Toit, George, Kaya, Guven, Gulec, Mustafa, Saldir, Mehmet, Sener, Osman, Hassan, Nagwa, Shaaban, Hala, El-Hariri, Hazem, Mahfouz, Ahmed Kamel Inas E., Gabor, Papp, Gabor, Biro, Csaba, Kovacs, Chawes, Bo, Bønnelykke, Klaus, Stokholm, Jakob, Heickendorff, Lene, Brix, Susanne, Rasmussen, Morten, Bisgaard, Hans, Hallas, Henrik Wegener, Arianto, Lambang, Pincus, Maike, Keil, Thomas, Reich, Andreas, Wahn, Ulrich, Lau, Susanne, Grabenhenrich, Linus, Fagerstedt, Sara, Hesla, Helena Marell, Johansson, Emelie, Rosenlund, Helen, Mie, Axel, Scheynius, Annika, Alm, Johan, Esparza-Gordillo, Jorge, Matanovic, Anja, Marenholz, Ingo, Bauerfeind, Anja, Rohde, Klaus, Nemat, Katja, Lee-Kirsch, Min-Ae, Nordenskjöld, Magnus, Winge, Marten C.G., Krüger, Renate, Beyer, Kirsten, Kalb, Birgit, Niggemann, Bodo, Hübner, Norbert, Cordell, Heather J., Bradley, Maria, Lee, Young-Ae, Gough, Hannah, Schramm, Dirk, Beschorner, John, Schuster, Antje, Bauer, Carl-Peter, Forster, Johannes, Zepp, Fred, Bergmann, Renate, Bergmann, Karl, Garcia, Filipe Benito, Santos, Natacha, Pité, Helena, Papadopoulou, Athina, Mermiri, Despina, Xatziagorou, Elpida, Tsanakas, Ioannis, Lampidi, Stavroula, Priftis, Kostas, Fuertes, Elaine, Markevych, Iana, Bowatte, Gayan, Gruzieva, Olena, Gehring, Ulrike, Becker, Allan, Berdel, Dietrich, Brauer, Michael, Carlsten, Chris, Hoffmann, Barbara, Kozyrskyj, Anita, Lodge, Caroline, Pershagen, Göran, Wijga, Alet, Joachim, Heinrich, Zivkovic, Zorica, Djuric-Filipovic, Ivana, Jocić-Stevanovic, Jasmina, Zivanovic, Snežana, Taka, Styliani, Kokkinou, Dimitra, Papakonstantinou, Aliki, Stefanopoulou, Panagiota, Georgountzou, Anastasia, Maggina, Paraskevi, Stamataki, Sofia, Papaevanggelou, Vassiliki, Andreakos, Evangelos, Gibert, Monica Piquer, Spera, Adriana Machinena, Deliu, Matea, Belgrave, Danielle, Simpson, Angela, Custovic, Adnan, Marques, João Gaspar, Carreiro-Martins, Pedro, Belo, Joana, Serranho, Sara, Peralta, Isabel, Neuparth, Nuno, Leiria-Pinto, Paula, Vazquez-Ortiz, Marta, Pascal, Mariona, Plaza, Ana Maria, Juan, Manel, Paparo, Lorella, Nocerino, Rita, Aitoro, Rosita, Langella, Ilaria, Amoroso, Antonio, Amoroso, Alessia, Di Scala, Carmen, Berni Canani, Roberto, Maity, Santanu, Rotiroti, Giuseppina, Gandhi, Minal, Jonsson, Karin, Ljung, Annika, Hesselmar, Bill, Adlerbert, Ingegerd, Brekke, Hilde, Johansen, Susanne, Wold, Agnes, Sandberg, Ann-Sofie, Nordlund, Björn, Lundholm, Cecilia, Ullemar, Villhelmina, van Hage, Marianne, Örtqvist, Anne, Almqvist, Catarina, Selby, Anna, Grimshaw, Kate, Clausen, Michael, Dubakiene, Ruta, Fiocchi, Alessandro, Kowalski, Marek, Papadopoulos, Nikos, Reche, Marta, Sigurdardottir, Sigurveig, Sprikkleman, Aline, Xepapadaki, Paraskevi, Mills, Clare, Roberts, Graham, Neto, Herberto Jose Chong, Wandalsen, Gustavo Falbo, Bianca, Ana Carolina Dela, Aranda, Carolina, Rosário, Nelson Augusto, Solé, Dirceu, Mallol, Javier, Marcos, Luis García, Banic, Ivana, Rijavec, Matija, Plavec, Davor, Korosec, Peter, Turkalj, Mirjana, Bozicevic, Alen, De Mieri, Maria, Hamburger, Matthias, Holley, Simone, Morris, Ruth, Mitchell, Frances, Knibb, Rebecca, Latter, Susan, Liossi, Christina, Hassan, Mostafa M. M., Barman, Malin, Sandin, Anna, Posa, Daniela, Perna, Serena, Hoffmann, Ute, Chen, Kuan-Wei, Resch, Yvonne, Vrtala, Susanne, Valenta, Rudolf, Matricardi, Paolo Maria, Tsilochristou, Olympia, Rohrbach, Alexander, Cappella, Antonio, Hofmaier, Stephanie, Hatzler, Laura, D’Amelio, Raffaele, Björkander, Sophia, Johansson, Maria A., Lasaviciute, Gintare, Sverremark-Ekström, Eva, Rüschendorf, Franz, Strachan, David P., Spycher, Ben D., Baurecht, Hansjörg, Margaritte-Jeannin, Patricia, Sääf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Söderhäll, Cilla, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrländer, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Fölster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Cichon, Sven, Nöthen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Schneider, Valentin, Heinig, Matthias, Holt, Patrick G., Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel AR, Laprise, Catherine, Freidin, Maxim B, Genuneit, Jon, Koppelman, Gerard H, Melén, Erik, Dizier, Marie-Hélène, John Henderson, A., Lee, Young Ae, González-Delgado, Purificacion, Caparrós, Esther, Clemente, Fernando, Cueva, Begoña, Moreno, Victoria M., Carretero, Jose Luis, Fernández, Javier, Swan, Kate, Gopi, Mudiyur, Smith, Tim, Ramesh, Edara, Sadasivam, Arun, Arêde, Cristina, Borrego, Luís Miguel, Pires, Graça, Santa-Marta, Cristina, Brand, Stephanie, Stein, Karina, Heine, Holger, Kauth, Marion, Rolfsjord, Leif Bjarte, Bakkeheim, Egil, Skjerven, Håvard Ove, Carlsen, Kai-Håkon, Hunderi, Jon Olav, Berents, Teresa Løvold, Mowinckel, Petter, Lødrup Carlsen, Karin C., Munzel, Ullrich, Berger, William, Valiente, Román, Vozmediano, Valvanera, Lukas, John C., Rodríguez, Mónica, Guarnaccia, Sebastiano, Vitale, Luigi, Pluda, Ada, D’Agata, Emanuele, Colombo, Denise, Felici, Stefano, Gretter, Valeria, Facchetti, Susanna, Pecorelli, Gaia, Quecchia, Cristina, Guibas, George, Spandou, Evangelia, Megremis, Spyridon, West, Peter, Papadopoulos, Nikolaos, Rufo, João Cavaleiro, Madureira, Joana, Paciência, Inês, Aguiar, Lívia, Padrão, Patrícia, Pinto, Mariana, Delgado, Luís, Moreira, Pedro, Teixeira, João Paulo, Fernandes, Eduardo Oliveira, Moreira, André, Dominguez, Adriana Izquierdo, Valero, Antonio, Mullol, Joaquim, Del Cuvillo, Alfonso, Montoro, Javier, Jauregui, Ignacio, Bartra, Joan, Davila, Ignacio, Ferrer, Marta, Sastre, Joaquin, Martins, Catarina, Lima, Jorge, Leandro, Maria José, Nunes, Glória, Branco, Jorge Cunha, Trindade, Hélder, Borrego, Luis Miguel, Conkar, Secil, Kilic, Mehtap, Aygun, Canan, Sancak, Recep, Tagalaki, Eleni, Banos, Lambros, Vlachou, Anna, Giannoula, Fotini, Pavlakou, Marina, Kryoni, Maria, Makris, Kostas, Lazova, Snezhina, Petrova, Guergana, Miteva, Dimitrinka, Perenovska, Penka, Klyucharova, Aliya, Skorohodkina, Olesya, Koumaki, Dimitra, Manousaki, Alkisti, Agrapidi, Maria, Iatridou, Lida, Eruk, Omima, Myridakis, Konstantinos, Manousakis, Emmanouil, Koumaki, Vasiliki, Dimou, Maria, Ingemansson, Maria, Hedlin, Gunilla, Pastor, Nitida, de Boissieu, Delphine, Vanderhoof, Jon, Moore, Nancy, Maditz, Kaitlin, Mehdi, Adeli, Elhassan, Shaza, Beck, Carolin, Al-Hammadi, Ahmed, Maris, Ioana, O’Sullivan, Ronan, Hourihane, Jonathan, Raptis, George, DunnGalvin, Audrey, Greenhawt, Matthew, Venter, Carina, O’Regan, Evelyn, Cronin, Duncan, O’Reilly, Anna, Abdelaziz, Foued, Khelifi-Touhami, Dounia, Selim, Nihad, Khelifi-Touhami, Tahar, Merida, Pablo, Plaza, Ana Mª, Castellanos, Juan Heber, Lozano, Jaime, Dominguez, Olga, Piquer, Monica, Jimenez, Rosa, Giner, Mª Teresa, Kakleas, Konstantinos, Joishy, Manohar, Maskele, Wendmu, Jenkins, Huw R., Escarrer, Mercedes, Madroñero, Agustín, Guerra, Maria Teresa, Julia, Juan Carlos, Cerda, Juan Carlos, Contreras, Javier, Tauler, Eulalia, Vidorreta, Maria Jesus, Rojo, Ana, Del Valle, Silvia, Flynn, Niamh, Foley, Gary, Harmon, Carol, Fitzsimons, John, Baynova, Krasimira, Del Robledo, Ávila Maria, Marina, Labella, Cortes, Aaron, Sciaraffia, Alicia, Castillo, Angela, Juel-Berg, Nanna, Hansen, Kirsten Skamstrup, Poulsen, Lars Kærgaard, Lazar, Adina, Aguiar, Rita, Lopes, Anabela, Paes, Maria J., Santos, Amélia S., Pereira-Barbosa, M. A., Eke Gungor, Hatice, Uytun, Salih, Sahiner, Umit Murat, Altuner Torun, Yasemin, Zivanovic, Mirjana, Atanasković-Marković, Marina, Vesel, Tina, Nahtigal, Mihaela, Obermayer-Temlin, Andreja, Križnik, Eva Šoster, Maslar, Mirjana, Bizjak, Ruben, Tomšič-Matic, Marjeta, Posega-Devetak, Sonja, Skerbinjek-Kavalar, Maja, Predalič, Mateja, Avčin, Tadej, Pouessel, Guillaume, Beaudouin, Etienne, Moneret-Vautrin, Anne M., Deschildre, Antoine, Viñas, Marta, Borja, Bartolomé, Hernández, Nora, Castillo, Mª José, Izquierdo, Adriana, Ibero, Marcel, Kocabas, Can Naci, Heming, Camille, Garrett, Emily, Blackstock, Adam, Chodhari, Rahul, Belohlavkova, Simona, Kopelentova, Eliska, Visek, Petr, Setinova, Ivana, Svarcova, Ivana, Sjölander, Sigrid, Nilsson, Nora, Berthold, Malin, Ekoff, Helena, Borres, Magnus, Nilsson, Caroline, González Domínguez, Loreto, Muñoz Archidona, Cristina, Moreira Jorge, Ana, Quevedo Teruel, Sergio, Bracamonte Bermejo, Teresa, Castillo Fernández, Miriam, Pineda de la Losa, Fernando, Echeverría Zudaire, Luis Ángel, Vrani, Olga, Mavroudi, Antigone, Fotoulaki, Maria, Emporiadou, Maria, Spiroglou, Kleomenis, Xinias, Ioannis, Sadreddini, Helyeh A., Warnes, Mia, Traves, Donna, Kostić, Gordana, Filipovic, Đorđe, Sittisomwong, Sawapon, Sittisomwong, Siripong, Podolec, Zygmunt, Hartel, Marcin, Panek, Daria, Podolec-Rubiś, Magdalena, Banasik, Tomasz, Abbasi, Elham, Moghtaderi, Mozhgan, Sanneerappa, Phani, Deliu, Alina, Kutty, Moosa, Ramesh, Nagabathula, Sherkat, Roya, Sabri, Mohammad Reza, Dehghan, Bahar, Bigdelian, Hamid, Raeesi, Nahid, Afshar, Mino, Rahimi, Hamid, Klein, Christoph, Al-Jebouri, Mohemid, Svitich, Oxana A., Zubacheva, Daria O., Potemkin, Dmitrii A., Gankovskaya, Ludmila V., Zverev, Vitalii V., OB Doyle, Elaine, Gallagher, Paul, Dewlett, Sherine, Man, Kin, Pocock, James, Gerrardhughes, Anna, Wasilewska, Jolanta, Kaczmarski, Maciej, Lebensztejn, Dariusz, Thuraisingham, Chandramani, Sinniah, Davendralingam, Chen, Yue, Mei, Xiaomei, Ozdogan, Sebnem, Karadeniz, Pinar, Ayyildiz-Emecen, Durdugul, Oncul, Ummuhan, Sari, Gizem, Cavdar, Sabanur, Farzan, Niloufar, Vijverberg, Susanne J., Palmer, Colin J., Tantisira, Kelan G., Maitland-van der Zee, Anke-Hilse, Yavuzyilmaz, Fatma, Urganci, Nafiye, Usta, Merve, Hoxha, Mehmet, Basho, Maksim, Wandalsen, Gustavo F., Monteiro, Fernanda, Lame, Blerta, Mesonjesi, Eris, Sherri, Arjeta, Ibranji, Alkerta, Gjati, Laert, Loloci, Gjustina, Bardhi, Ardii, Moghtaderi, Behnam, Farjadian, Shirin, Eghtedari, Dorna, Olaya, Manuela, Del Mar Vasquez, Laura, Ramirez, Luis Fernando, Serrano, Carlos Daniel, Usta Guc, Belgin, Asilsoy, Suna, Ozer, Fulya, Shopova, Sylvia, Papochieva, Vera, Loekmanwidjaja, Jessica, Mallozi, Márcia, Ratner, Paul, Soteres, Daniel, Novák, Zoltán, Yáñez, Anahí, Ildikó, Kiss, Kuna, Piotr, Tortajada, Miguel, Feuerhahn, Julia, Blome, Christine, Hadler, Meike, Karagiannis, Efstrathios, Langenbruch, Anna, Augustin, Matthias, Roux, Michel, Kakudo, Shinji, Zeldin, Robert K., Sokolova, Anna, Silva, Tiago Milheiro, Zivanovic, Snezana S., Cvetkovic, Vesna, Nikolic, Ivana, Zivanovic, Sonja J., Saranac, Ljiljana, Nesterenko, Zoia, Radic, Snezana, Milenkovic, Branislava, Smiljanic, Spomenka, Micic-Stanijevic, Milka, Calovic, Olivera, Hofbauer, Anne Marie Bro, Agertoft, Lone, Everson, Lucy, Kearney, Jessica, Coppel, Jonny, Braithwaite, Simon, Christiansen, Elisabeth S., Kjaer, Henrik Fomsgaard, Eller, Esben, Mørtz, Charlotte G., Halken, Susanne, Román India, Cristina, Jiménez Jiménez, Juana, Echeverría Zudaire, Luis, O’Connor, Cathal, Kanti, Varvara, Lünnemann, Lena, Malise, Günther, Ludriksone, Laine, Stroux, Andrea, Henrich, Wolfgang, Abu-Dakn, Michael, Blume-Peytavi, Ulrike, Garcia Bartels, Natalie, Schario, Marianne, Stanley, Thorsten, Brandenbarg, Nicolien, Boardman, Alia, McGreevy, Gary, Rodger, Emily, Knight, Katherine, Taylor, Trisha, Scanlan, Gemma, Christoph, Grüber, van Stuivenberg, Margriet, Mosca, Fabio, Moro, Guido, Chirico, Gaetano, Braegger, Christian P., Riedler, Joseph, Yavuz, Yalcin, Boehm, Günther, Arasi, Stefania, Crisafulli, Giuseppe, Caminiti, Lucia, Porcaro, Federica, Pajno, Giovanni Battista, Tanaka, Akane, Togawa, Yaei, Oida, Kumiko, Kambe, Naotomo, Arkwright, Peter, Amagai, Yosuke, Shimojo, Naoki, Sato, Yasunori, Mochizuki, Hiroyuki, Jang, Hyosun, Ishizaka, Saori, Matsuda, Hiroshi, Barlianto, Wisnu, Olivianto, Ery, Chandra Kusuma, H. M. S., Mollica, Mariapia, Trinchese, Giovanna, Alfano, Elena, Amato, Francesco, Pirozzi, Claudio, Calignano, Antonio, Meli, Rosaria, Rossberg, Siri, Gerhold, Kerstin, Zimmermann, Kurt, Zaino, Mohammad, Geske, Thomas, Hamelmann, Eckard, Bogovic, Sarah, van den Berg, Jochem, Janssen, Chantal, Claver, Angela, Martin-Muñoz, Mª Flor, Martorell, C., Belver, M. T., Alonso Lebrero, E., Zapatero, L., Fuentes, V., Piqué, M., Plaza, A., Muñoz, C., Blasco, Cristina, Villa, B., Gómez, C., Nevot, S., García, J. M., Echeverria, L., DeWitt, Brenda, Holloway, Judith, Hodge, Donald, Ludman, Sian, Jafari-Mamaghani, Merhdad, Ebling, Rosemary, Fox, Adam T., Lack, Gideon, Lovén Björkman, Sofia, Ballardini, Natalia, Basu, Supriyo, Hallet, Jenny, Srinivas, Jyothi, Stringer, Hazel, Jay, Nicola, Fonseca, Paula, Vieira, Clara, Mastrorilli, Carla, Caffarelli, Carlo, Asero, Riccardo, Tripodi, Salvatore, Dondi, Arianna, Ricci, Gianpaolo, Povesi Dascola, Carlotta, Calamelli, Elisabetta, Cipriani, Francesca, Di Rienzo Businco, Andrea, Bianchi, Annamaria, Candelotti, Paolo, Frediani, Tullio, Verga, Carmen, Korovessi, Paraskevi, Tiliakou, Skevi, Tavoulari, Evaggelia, Moraiti, Kalliopi-Maria, Tee, Wan Jean, Deiratany, Samir, Seedhoo, Raymond, McNamara, Roisin, Okafor, Ike, Khaleva, Ekaterina, Novic, Gennady, Bychkova, Natalia, Abd Al-Aziz, Amany, Fatouh, Amany, Motawie, Ayat, Bostany, Eman El, Ibrahim, Amr, Andonova, Sylvia, Savov, Alexey, Zoto, Maria, Kyriakakou, Marialena, Vassilopoulou, Mariza, Balaska, Athina, Kostaridou, Stavroula, Wartna, Jorien, Bohnen, Arthur M., Elshout, Gijs, Pols, David H. J., Bindels, Patrick J. E., Seys, Sven F., Dilissen, Ellen, Van der Eycken, Sarah, Schelpe, An-Sofie, Marijsse, Gudrun, Troosters, Thierry, Vanbelle, Vincent, Aertgeerts, Sven, Ceuppens, Jan L., Dupont, Lieven J., Peers, Koen, Bullens, Dominique M., Lokas, Sandra Bulat, Zivkovic, Jelena, Nogalo, Boro, Kobal, Iva Mrkic, Oliveira, Georgeta, Pike, Katharine, Melo, Alda, Amélia, Tomás, Cidrais Rodrigues, José Carlos, Serrano, Cristina, Lopes dos Santos, José Manuel, Lopes, Carla, Schauer, Uwe, Bergmann, Karl-Christian, Moral, Luis, Toral, Teresa, Marco, Nuria, Avilés, Beléns García, Fuentes, Mª Jesús, Garde, Jesús, Montahud, Cristina, Perona, Javier, Forniés, Mª José, Arroabarren, Esozia, Anda, Marta, Sanz, Maria Luisa, Lizaso, Maria Teresa, Arregui, Candida, May, Sara, Hartz, Martha, Joshi, Avni, Park, Miguel A., Posega Devetak, Sonja, Koren Jeverica, Anja, Castro, Leonor, Gouveia, Carolina, Marques, Ana Carvalho, Cabral, Antonio Jorge, Amaral, Luis, Carolino, Fabrícia, Castro, Eunice, Passos, Madalena, Cernadas, Josefina R., Amaral, Luís, Dias de Castro, Eunice, Pineda, Fernando, Gomes, Armanda, Brough, Helen, Röhmel, Jobst, Schwarz, Carsten, Mehl, Anne, Stock, Philippe, Staab, Doris, Seib, Christine, Critchlow, Anita, Barber, Alyson, Delavalle, Belen, Garriga, Teresa, Vilá, Blanca, Astolfi, Annalisa, Di Chiara, Costanza, Neri, Iria, Patrizi, Annalisa, Neskorodova, Katerina, Kudryavtseva, Asya, Alvarez, Jorge, Palacios, Miriam, Martinez-Merino, Marta, and Vaquero, Ibone
- Abstract
Table of contents WORKSHOP 4: Challenging clinical scenarios (CS01–CS06) CS01 Bullous lesions in two children: solitary mastocytoma S. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal Gok CS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experience Jessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise Michaelis CS03 Cold urticaria in pediatric age: an invisible cause for severe reactions Inês Mota, Ângela Gaspar, Susana Piedade, Graça Sampaio, José Geraldo Dias, Miguel Paiva, Mário Morais-Almeida CS04 Angioedema with C1 inhibitor deficiency in a girl: a challenge diagnosis Cristina Madureira, Tânia Lopes, Susana Lopes, Filipa Almeida, Alexandra Sequeira, Fernanda Carvalho, José Oliveira CS05 A child with unusual multiple organ allergy disease: what is the primer? Fabienne Gay-Crosier CS06 A case of uncontrolled asthma in a 6-year-old patient Ioana-Valentina Nenciu, Andreia Florina Nita, Alexandru Ulmeanu, Dumitru Oraseanu, Carmen Zapucioiu ORAL ABSTRACT SESSION 1: Food allergy (OP01–OP06) OP01 Food protein-induced enterocolitis syndrome: oral food challenge outcomes for tolerance evaluation in a Pediatric Hospital Adrianna Machinena, Olga Domínguez Sánchez, Montserrat Alvaro Lozano, Rosa Jimenez Feijoo, Jaime Lozano Blasco, Mònica Piquer Gibert, Mª Teresa Giner Muñoz, Marcia Dias da Costa, Ana Maria Plaza Martín OP02 Characteristics of infants with food protein-induced enterocolitis syndrome and allergic proctocolitis Ebru Arik Yilmaz, Özlem Cavkaytar, Betul Buyuktiryaki, Ozge Soyer, Cansin Sackesen OP03 The clinical and immunological outcomes after consumption of baked egg by 1–5 year old egg allergic children: results of a randomised controlled trial MerrynNetting, Adaweyah El-Merhibi, Michael Gold, PatrickQuinn, IrmeliPenttila, Maria Makrides OP04 Oral immunotherapy for treatment of egg allergy using low allergenic, hydrolysed egg Stavroula Giavi, Antonella Muraro, Roger Lauener, Annick Mercenier, Eugen Bersuch, Isabella M. Montagner, Maria Passioti, Nicolò Celegato, Selina Summermatter, Sophie Nutten, Tristan Bourdeau, Yvonne M. Vissers, Nikolaos G. Papadopoulos OP05 Chemical modification of a peanut extract results in an increased safety profile while maintaining efficacy Hanneke van der Kleij, Hans Warmenhoven, Ronald van Ree, Raymond Pieters, Dirk Jan Opstelten, Hans van Schijndel, Joost Smit OP06 Administration of the yellow fever vaccine in egg allergic children Roisin Fitzsimons, Victoria Timms, George Du Toit ORAL ABSTRACT SESSION 2: Asthma (OP07–OP12) OP07 Previous exacerbation is the most important risk factor for future exacerbations in school-age children with asthma S. Tolga Yavuz, Guven Kaya, Mustafa Gulec, Mehmet Saldir, Osman Sener, Faysal Gok OP08 Comparative study of degree of severity and laboratory changes between asthmatic children using different acupuncture modalities Nagwa Hassan, Hala Shaaban, Hazem El-Hariri, Ahmed Kamel Inas E. Mahfouz OP09 The concentration of exhaled carbon monoxide in asthmatic children with different controlled stadium Papp Gabor, Biro Gabor, Kovacs Csaba OP10 Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomised clinical trial Bo Chawes, Klaus Bønnelykke, Jakob Stokholm, Lene Heickendorff, Susanne Brix, Morten Rasmussen, Hans Bisgaard OP11 Lung function development in childhood Henrik Wegener Hallas, Bo Chawes, Lambang Arianto, Hans Bisgaard OP12 Is the effect of maternal and paternal asthma different in female and male children before puberty? Maike Pincus, Thomas Keil, Andreas Reich, Ulrich Wahn, Susanne Lau, Linus Grabenhenrich ORAL ABSTRACT SESSION 3: Epidemiology—genetics (OP13–OP18) OP13 Lifestyle is associated with incidence and category of allergen sensitisation: the ALADDIN birth cohort Sara Fagerstedt, Helena Marell Hesla, Emelie Johansson, Helen Rosenlund, Axel Mie, Annika Scheynius, Johan Alm OP15 Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance Jorge Esparza-Gordillo, Anja Matanovic, Ingo Marenholz, Anja Bauerfeind, Klaus Rohde, Katja Nemat, Min-Ae Lee-Kirsch, Magnus Nordenskjöld, Marten C. G. Winge, Thomas Keil, Renate Krüger, Susanne Lau, Kirsten Beyer, Birgit Kalb, Bodo Niggemann, Norbert Hübner, Heather J. Cordell, Maria Bradley, Young-Ae Lee OP16 Allergic multimorbidity of asthma, rhinitis and eczema in the first 2 decades of the German MAS birth cohort Thomas Keil, Hannah Gough, Linus Grabenhenrich, Dirk Schramm, Andreas Reich, John Beschorner, Antje Schuster, Carl-Peter Bauer, Johannes Forster, Fred Zepp, Young-Ae Lee, Renate Bergmann, Karl Bergmann, Ulrich Wahn, Susanne Lau OP17 Childhood anaphylaxis: a growing concern Filipe Benito Garcia, Inês Mota, Susana Piedade, Ângela Gaspar, Natacha Santos, Helena Pité, Mário Morais-Almeida OP18 Indoor exposure to molds and dampness in infancy and its association to persistent atopic dermatitis in school age. Results from the Greek ISAAC II study Athina Papadopoulou, Despina Mermiri, Elpida Xatziagorou, Ioannis Tsanakas, Stavroula Lampidi, Kostas Priftis ORAL ABSTRACT SESSION 4: Pediatric rhinitis—immunotherapy (OP19–OP24) OP19 Associations between residential greenness and childhood allergic rhinitis and aeroallergen sensitisation in seven birth cohorts Elaine Fuertes, Iana Markevych, Gayan Bowatte, Olena Gruzieva, Ulrike Gehring, Allan Becker, Dietrich Berdel, Michael Brauer, Chris Carlsten, Barbara Hoffmann, Anita Kozyrskyj, Caroline Lodge, Göran Pershagen, Alet Wijga, Heinrich Joachim OP20 Full symptom control in pediatric patients with allergic rhinitis and asthma: results of a 2-year sublingual allergen immunotherapy study Zorica Zivkovic, Ivana Djuric-Filipovic, Jasmina Jocić-Stevanovic, Snežana Zivanovic OP21 Nasal epithelium of different ages of atopic subjects present increased levels of oxidative stress and increased cell cytotoxicity upon rhinovirus infection Styliani Taka, Dimitra Kokkinou, Aliki Papakonstantinou, Panagiota Stefanopoulou, Anastasia Georgountzou, Paraskevi Maggina, Sofia Stamataki, Vassiliki Papaevanggelou, Evangelos Andreakos, Nikolaos G. Papadopoulos OP22 Cluster subcutaneous immunotherapy schedule: tolerability profile in children Monica Piquer Gibert, Montserrat Alvaro Lozano, Jaime Lozano Blasco, Olga Domínguez Sánchez, Rosa Jiménez Feijoo, Marcia Dias da Costa, Mª Teresa Giner Muñoz, Adriana Machinena Spera, Ana Maria Plaza Martín OP23 Rhinitis as a risk factor for asthma severity in 11-year old children: population-based cohort study Matea Deliu, Danielle Belgrave, Angela Simpson, Adnan Custovic OP24 The Global Lung Function Initiative equations in airway obstruction evaluation of asthmatic children João Gaspar Marques, Pedro Carreiro-Martins, Joana Belo, Sara Serranho, Isabel Peralta, Nuno Neuparth, Paula Leiria-Pinto POSTER DISCUSSION SESSION 1: Food allergy (PD01–PD05) PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactions Marta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel Juan PD02 FoxP3 epigenetic features in children with cow milk allergy Lorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni Canani PD04 Combined milk and egg allergy in early childhood: let them eat cake? Santanu Maity, Giuseppina Rotiroti, Minal Gandhi PD05 Introduction of complementary foods in relation to allergy and gut microbiota in farm and non-farm children Karin Jonsson, Annika Ljung, Bill Hesselmar, Ingegerd Adlerbert, Hilde Brekke, Susanne Johansen, Agnes Wold, Ann-Sofie Sandberg POSTER DISCUSSION SESSION 2: Asthma and wheeze (PD06–PD16) PD06 The association between asthma and exhaled nitric oxide is influenced by genetics and sensitisation Björn Nordlund, Cecilia Lundholm, Villhelmina Ullemar, Marianne van Hage, Anne Örtqvist, Catarina Almqvist PD09 Prevalence patterns of infant wheeze across Europe Anna Selby, Kate Grimshaw, Thomas Keil, Linus Grabenhenrich, Michael Clausen, Ruta Dubakiene, Alessandro Fiocchi, Marek Kowalski, Nikos Papadopoulos, Marta Reche, Sigurveig Sigurdardottir, Aline Sprikkleman, Paraskevi Xepapadaki, Clare Mills, Kirsten Beyer, Graham Roberts PD10 Epidemiologic changes in recurrent wheezing infants Herberto Jose Chong Neto, Gustavo Falbo Wandalsen, Ana Carolina Dela Bianca, Carolina Aranda, Nelson Augusto Rosário, Dirceu Solé, Javier Mallol, Luis García Marcos PD13 A single nucleotide polymorphism in the GLCCI1 gene is associated with response to asthma treatment in children IvanaBanic, Matija Rijavec, Davor Plavec, Peter Korosec, Mirjana Turkalj PD14 Pollen induced asthma: Could small molecules in pollen exacerbate the protein-mediated allergic response? Alen Bozicevic, Maria De Mieri, Matthias Hamburger PD15 A qualitative study to understand how we can empower teenagers to better self-manage their asthma Simone Holley, Ruth Morris, Frances Mitchell, Rebecca Knibb, Susan Latter, Christina Liossi, Graham Roberts PD16 Polymorphism of endothelial nitric oxide synthase (eNOS) gene among Egyptian children with bronchial asthma Mostafa M. M. Hassan POSTER DISCUSSION SESSION 3: Mechanisms—Epidemiology (PD17–PD21) PD17 Pregnancy outcomes in relation to development of allergy in a Swedish birth cohort Malin Barman, Anna Sandin, Agnes Wold, Ann-Sofie Sandberg PD18 Evolution of the IgE response to house dust mite molecules in childhood Daniela Posa, Serena Perna, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Kuan-Wei Chen, Yvonne Resch, Susanne Vrtala, Rudolf Valenta, Paolo Maria Matricardi PD19 Antibody recognition of nsLTP-molecules as antigens but not as allergens in the German-MAS birth cohort Olympia Tsilochristou, Alexander Rohrbach, Antonio Cappella, Stephanie Hofmaier, Laura Hatzler, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, RaffaeleD’Amelio, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi PD20 Early life colonization with Lactobacilli and Staphylococcus aureus oppositely associates with the maturation and activation of FOXP3+ CD4 T-cells Sophia Björkander, Maria A. Johansson, Gintare Lasaviciute, Eva Sverremark-Ekström PD21 Genome-wide meta-analysis identifies 7 susceptibility loci involved in the atopic march Ingo Marenholz, Jorge Esparza-Gordillo, Franz Rüschendorf, Anja Bauerfeind, David P. Strachan, Ben D. Spycher, Hansjörg Baurecht, Patricia Margaritte-Jeannin, Annika Sääf, Marjan Kerkhof, Markus Ege, Svetlana Baltic, Melanie C Matheson, Jin Li, Sven Michel, Wei Q. Ang, Wendy McArdle, Andreas Arnold, Georg Homuth, Florence Demenais, Emmanuelle Bouzigon, Cilla Söderhäll, Göran Pershagen, Johan C. de Jongste, Dirkje S Postma, Charlotte Braun-Fahrländer, Elisabeth Horak, Ludmila M. Ogorodova, Valery P. Puzyrev, Elena Yu Bragina, Thomas J Hudson, Charles Morin, David L Duffy, Guy B Marks, Colin F Robertson, Grant W Montgomery, Bill Musk, Philip J Thompson, Nicholas G. Martin, Alan James, Patrick Sleiman, Elina Toskala, Elke Rodriguez, Regina Fölster-Holst, Andre Franke, Wolfgang Lieb, Christian Gieger, Andrea Heinzmann, Ernst Rietschel, Thomas Keil, Sven Cichon, Markus M Nöthen, Craig E Pennell, Peter D Sly, Carsten O Schmidt, Anja Matanovic, Valentin Schneider, Matthias Heinig, Norbert Hübner, Patrick G. Holt, Susanne Lau, Michael Kabesch, Stefan Weidinger, Hakon Hakonarson, Manuel AR Ferreira, Catherine Laprise, Maxim B. Freidin, Jon Genuneit, Gerard H Koppelman, Erik Melén, Marie-Hélène Dizier, A. John Henderson, Young Ae Lee POSTER DISCUSSION SESSION 4: Food allergy—Anaphylaxis (PD22–PD26) PD22 Atopy patch test in food protein induced enterocolitis caused by solid food Purificacion González-Delgado, Esther Caparrós, Fernando Clemente, Begoña Cueva, Victoria M. Moreno, Jose Luis Carretero, Javier Fernández PD23 Watermelon allergy: a novel presentation Kate Swan, George Du Toit PD24 A pilot study evaluating the usefulness of a guideline template for managing milk allergy in primary care Mudiyur Gopi, Tim Smith, Edara Ramesh, Arun Sadasivam PD26 Efficacy and safety of cow’s milk oral immunotherapy protocol Inês Mota, Filipe Benito Garcia, Susana Piedade, Angela Gaspar, Graça Sampaio, Cristina Arêde, Luís Miguel Borrego, Graça Pires, Cristina Santa-Marta, Mário Morais-Almeida POSTER DISCUSSION SESSION 5: Prevention and treatment—Allergy (PD27–PD36) PD27 Allergy-protection by the lactic acid bacterium Lactococcus lactis G121: mode-of-action as revealed in a murine model of experimental allergy Stephanie Brand, Karina Stein, Holger Heine, Marion Kauth PD29 The relationship between quality of life and morning salivary cortisol after acute bronchiolitis in infancy Leif Bjarte Rolfsjord, Egil Bakkeheim, Johan Alm, Håvard Ove Skjerven, Kai-Håkon Carlsen, Jon Olav Hunderi, Teresa Løvold Berents, Petter Mowinckel, Karin C. Lødrup Carlsen PD30 Randomised trial of the efficacy of MP29-02* compared with fluticasone propionate nasal spray in children aged ≥6 years to <12 years with allergic rhinitis Ulrich Wahn, Ullrich Munzel, William Berger PD31 10 mg of oral bilastine in 2 to 11 years old children has similar exposure to the adult therapeutic dose (20 mg) Ulrich Wahn, Román Valiente, Valvanera Vozmediano, John C. Lukas, Mónica Rodríguez PD33 Daily symptoms, nocturnal symptoms, activity limitations and reliever therapies during the three steps of IOEASMA programme: a comparison Sebastiano Guarnaccia, Luigi Vitale, Ada Pluda, Emanuele D’Agata, Denise Colombo, Stefano Felici, Valeria Gretter, Susanna Facchetti, Gaia Pecorelli, Cristina Quecchia PD34 Sensitisation to an inert aeroallergen in weaning rats and longstanding disease, in a sensitisation-tolerant and easily tolerisable rodent strain George Guibas, Evangelia Spandou, Spyridon Megremis, Peter West, Nikolaos Papadopoulos PD35 Bacterial and fungi exposure in school and allergic sensitisation in children João Cavaleiro Rufo, Joana Madureira, Inês Paciência, Lívia Aguiar, Patrícia Padrão, Mariana Pinto, Luís Delgado, Pedro Moreira, João Paulo Teixeira, Eduardo Oliveira Fernandes, André Moreira PD36 Comparative study of allergy rhinitis between two populations: children vs. adults Adriana Izquierdo Dominguez, Antonio Valero, Joaquim Mullol, Alfonso Del Cuvillo, Javier Montoro, Ignacio Jauregui, Joan Bartra, Ignacio Davila, Marta Ferrer, Joaquin Sastre POSTER VIEWING SESSION 1: Inflammation—Genetics—Immunology—Dermatology (PP01–PP09) PP01 Immune profile in late pregnancy: immunological markers in atopic asthmaticwomen as risk factors for atopy in the progeny Catarina Martins, Jorge Lima, Maria José Leandro, Glória Nunes, Jorge Cunha Branco, Hélder Trindade, Luis Miguel Borrego PP02 The impact of neonatal sepsis on development of allergic diseases Secil Conkar, Mehtap Kilic, Canan Aygun, Recep Sancak PP03 Clinical overview of selective IgE deficiency in childhood Athina Papadopoulou, Eleni Tagalaki, Lambros Banos, Anna Vlachou, Fotini Giannoula, Despina Mermiri PP04 Inverse relationship between serum 25(ΟΗ) vitamin D3 and total IgE in children and adolescence Athina Papadopoulou, Stavroula Lampidi, Marina Pavlakou, Maria Kryoni, Kostas Makris PP05 PP06 PP07 Asthma control questionnaire and specific IgE in children Snezhina Lazova, Guergana Petrova, Dimitrinka Miteva, Penka Perenovska PP08 Features of chronic urticaria of adolescents Aliya Klyucharova, Olesya Skorohodkina PP09 Cutaneous mastocytosis in children: a clinical analysis of 8 cases in Greece Dimitra Koumaki, Alkisti Manousaki, Maria Agrapidi, Lida Iatridou, Omima Eruk, Konstantinos Myridakis, Emmanouil Manousakis, Vasiliki Koumaki POSTER VIEWING SESSION 2: Food allergy—Anaphylaxis (PP10–PP47) PP10 Prognostic factors in egg allergy Maria Dimou, Maria Ingemansson, Gunilla Hedlin PP11 Evaluation of the efficacy of an amino acid-based formula in infants who are intolerant to extensively hydrolysed protein formula Nitida Pastor, Delphine de Boissieu, Jon Vanderhoof, Nancy Moore, Kaitlin Maditz PP12 Anaphylaxis and epinephrine auto-injector use: a survey of pediatric trainees Adeli Mehdi, Shaza Elhassan, Carolin Beck, Ahmed Al-Hammadi PP13 Anaphylaxis in children: acute management in the Emergency Department Ioana Maris, Ronan O’Sullivan, Jonathan Hourihane, PP14 Understanding Cumbrian schools preparedness in managing children at risk of anaphylaxis in order to provide training and support which will create healthy and safe environments for children with allergies George Raptis, Louise Michaelis PP15 A new valid and reliable parent and child questionnaire to measure the impact of food protein enterocolitis syndrome on children: the FPIES Quality of Life Questionnaire (FPIESQL), Parent and Child Short Form Audrey DunnGalvin, Matthew Greenhawt, Carina Venter, Jonathan Hourihane PP16 An in-depth case study investigation of the experiences of teenagers and young adults in growing up and living with food allergy with emphasis on coping, management and risk, support, and social and self-identity Evelyn O’Regan, Duncan Cronin, Jonathan Hourihane, Anna O’Reilly, Audrey DunnGalvin PP17 Cow’s milk protein allergy in Constantine. A retrospective study of 62 cases between 1996 and 2013 Foued Abdelaziz, Dounia Khelifi-Touhami, Nihad Selim, Tahar Khelifi-Touhami PP18 PP19 Cow’s milk and egg oral immunotherapy in children older than 5 years Pablo Merida, Ana Mª Plaza, Juan Heber Castellanos, Adrianna Machinena, Montserrat Alvaro Lozano, Jaime Lozano, Olga Dominguez, Monica Piquer, Rosa Jimenez, Mª Teresa Giner PP20 Professionals’ awareness of management of Cow’s Milk Protein Allergy (CMPA) in North Wales Hospitals Konstantinos Kakleas, Manohar Joishy, Wendmu Maskele, Huw R. Jenkins PP21 PP22 Anaphylaxis: the great unknown for teachers. Presentation of a protocol for schools Mercedes Escarrer, Agustín Madroñero, Maria Teresa Guerra, Juan Carlos Julia, Juan Carlos Cerda, Javier Contreras, Eulalia Tauler, Maria Jesus Vidorreta, Ana Rojo, Silvia Del Valle PP23 Challenges facing children with food allergies and their parents in out of school activity sectors Niamh Flynn PP24 A review of food challenges at a Regional Irish Centre Gary Foley, Carol Harmon, John Fitzsimons PP25 The use of epinephrine in infants with anaphylaxis Krasimira Baynova, Ávila Maria Del Robledo, Labella Marina PP26 PP27 PP28 Mother’s psychological state predicts the expression of symptoms in food allergic children Aaron Cortes, Alicia Sciaraffia, Angela Castillo PP29 The correlation between sIgE towards tree nuts and birch pollen in a Danish Pediatric Allergy Clinic Nanna Juel-Berg, Kirsten Skamstrup Hansen, Lars Kærgaard Poulsen PP30 Food allergy in children: evaluation of parents’ use of online social media Andreia Florina Nita, Ioana Valentina Nenciu, Adina Lazar, Dumitru Oraseanu PP31 The impact of food allergy on quality of life: FAQLQ questionnaire Rita Aguiar, Anabela Lopes, Maria J. Paes, Amélia S. Santos, M. A. Pereira-Barbosa PP32 An unexpected cause of anaphylaxis: potato Hatice Eke Gungor, Salih Uytun, Umit Murat Sahiner, Yasemin Altuner Torun PP33 Is it clinical phenotype of allergic diseases determined by sensitisation to food? Mirjana Zivanovic, Marina Atanasković-Marković PP34 PP35 Prescribing adrenaline auto-injectors in children in 2014: the data from regional pediatricians Tina Vesel, Mihaela Nahtigal, Andreja Obermayer-Temlin, Eva Šoster Križnik, Mirjana Maslar, Ruben Bizjak, Marjeta Tomšič-Matic, Sonja Posega-Devetak, Maja Skerbinjek-Kavalar, Mateja Predalič, Tadej Avčin PP36 Who should have an adrenaline autoinjector? Adherence to the European and French guidelines among 121 allergists from the Allergy Vigilance Network Guillaume Pouessel, Etienne Beaudouin, Anne M. Moneret-Vautrin, Antoine Deschildre, Allergy Vigilance Network PP37 Anaphylaxis by Anacardium Occidentale Marta Viñas, Bartolomé Borja, Nora Hernández, Mª José Castillo, Adriana Izquierdo, Marcel Ibero PP38 Anaphylaxis with honey in a child S. Tolga Yavuz, Ali Gungor, Betul Buyuktiryaki, Ozan Koc, Can Naci Kocabas, Faysal Gok PP39 Evaluation of courses adopted to children on prevention, recognition and management of anaphylaxis Tina Vesel, Mihaela Nahtigal PP40 Symptomatic dust mites and shrimp allergy: three pediatric case reports Filipa Almeida, Susana Lopes, Cristina Madureira, Tânia Lopes, Fernanda Carvalho PP41 Poor identification rates of nuts by high risk individuals: a call for improved education and support for families Camille Heming, Emily Garrett, Adam Blackstock, Santanu Maity, Rahul Chodhari PP42 DAFALL: database of food allergies in the Czech Republic Simona Belohlavkova, Eliska Kopelentova, Petr Visek, Ivana Setinova, Ivana Svarcova PP43 Serological cross-reactivity between grass and wheat is not only caused by profilins and CCDs Sigrid Sjölander, Nora Nilsson, Malin Berthold, Helena Ekoff, Gunilla Hedlin, Magnus Borres, Caroline Nilsson PP44 Oil body associated proteins in children with nuts allergy. Allergens to consider in IgE-mediated nuts allergy Loreto González Domínguez, Cristina Muñoz Archidona, Ana Moreira Jorge, Sergio Quevedo Teruel, Teresa Bracamonte Bermejo, Miriam Castillo Fernández, Fernando Pineda de la Losa, Luis Ángel Echeverría Zudaire PP45 PP46 Protective effect of helicobacter pylori infection against food allergy in children Olga Vrani, Antigone Mavroudi, Maria Fotoulaki, Maria Emporiadou, Kleomenis Spiroglou, Ioannis Xinias PP47 Anaphylaxis pathway: A road tryp-tase to success? Helyeh A. Sadreddini, Mia Warnes, Donna Traves POSTER VIEWING SESSION 3: Miscellaneous (PP48–PP58) PP48 Surveillance study on safety of SLIT in pediatric population Ivana Djuric-Filipovic, Zorica Zivkovic, Snežana Zivanovic, Gordana Kostić, Đorđe Filipovic PP49 Efficacy and safety of mixed mite subcutaneous immunotherapy among allergic rhinitis patients in the Northeastern Thailand Sawapon Sittisomwong, Siripong Sittisomwong PP50 Effect of inhaled beclomethasone or placebo on brain stem activity in a patient chronically treated with steroids: preliminary report Zygmunt Podolec, Marcin Hartel, Daria Panek, Magdalena Podolec-Rubiś, Tomasz Banasik PP51 Sensitisation to aeroallergens in patients with allergic rhinitis, asthma and atopic dermatitis in Shiraz, Southwestern Iran Elham Abbasi, Mozhgan Moghtaderi PP52 Referring a child for allergy test: how appropriate are we? Phani Sanneerappa, Alina Deliu, Moosa Kutty, Nagabathula Ramesh PP53 EBV lymphoproliferative disease and cardiac lymphoma in a STK4 deficient patient Roya Sherkat, Mohammad Reza Sabri, Bahar Dehghan, Hamid Bigdelian, Nahid Raeesi, Mino Afshar, Hamid Rahimi, Christoph Klein PP54 A case study: the effect of massive honeybees attack on various body parameters atopic girl including allergy Mohemid Al-Jebouri PP55 The role of TLR9, NLRP3 and proIL-1β in activation of antiviral innate immunity Oxana A. Svitich, Daria O. Zubacheva, Dmitrii A. Potemkin, Ludmila V. Gankovskaya, Vitalii V. Zverev PP56 Overnight pulse oximetry, as a screening tool to diagnose obstructive sleep apnoea. How effective is it? Phani Sanneerappa, Elaine OB Doyle, Paul Gallagher, Nagabathula Ramesh PP57 The presentation and management of acute urticaria and allergic reactions in children in a multi-ethnic, inner city Emergency Department (ED) Sherine Dewlett, Kin Man, Minal Gandhi, James Pocock, Anna Gerrardhughes PP58 Food allergens responsible for delayed-type sensitisation in atopy patch test in children diagnosed with autism spectrum disorder Jolanta Wasilewska, Maciej Kaczmarski, Dariusz Lebensztejn POSTER VIEWING SESSION 4: Asthma—Rhinitis (PP59–PP87) PP59 Systematic review of incense as a trigger factor for asthma Chandramani Thuraisingham, Davendralingam Sinniah PP60 Increased risks of mood and anxiety disorders in children with asthma Yue Chen, Xiaomei Mei PP61 PP62 Asthma Control Test (ACT) and Pediatric Asthma Quality of Life Questionnaire (PAQLQ) association in children Sebnem Ozdogan, Pinar Karadeniz, Durdugul Ayyildiz-Emecen, Ummuhan Oncul PP63 Seasonal and gender variations in vitamin D levels in children with asthma and its association with pulmonary function tests Sebnem Ozdogan, Gizem Sari, Sabanur Cavdar PP64 Defining treatment response in childhood asthma: rationale and design of the Pharmacogenomics in the Childhood Asthma (PiCA) consortium Niloufar Farzan, Susanne J. Vijverberg, Colin J. Palmer, Kelan G. Tantisira, Anke-Hilseon Maitland-van der Zee behalf of the PiCA consortium PP65 Prevalence of asthma and allergic disease in patients with inflammatory disease compared to celiac disease Fatma Yavuzyilmaz, Sebnem Ozdogan, Nafiye Urganci, Merve Usta PP66 A severe case with cystic fibrosis (CF) asthma Mehmet Hoxha, Maksim Basho PP67 Severe asthma exacerbation complicated with pneumothorax in a child with uncontrolled asthma due to poor treatment compliance Ioana Valentina Nenciu, Andreia Florina Nita, Adina Lazar, Alexandru Ulmeanu, Carmen Zapucioiu, Dumitru Oraseanu PP68 Evaluation of the Pediatric Quality of Life inventory (PedsQL) asthma module among low income asthmatic children and adolescents in Sao Paolo, Brazil Gustavo F. Wandalsen, Fernanda Monteiro, Dirceu Solé PP69 Early initiation of specific immunotherapy in asthma patients leads to higher benefits Blerta Lame, Eris Mesonjesi, Arjeta Sherri PP70 Treatment resistant asthma and rhinosinusitis with recurrent pulmonary infections. Is it primary ciliary dyskinesia? Alkerta Ibranji, Laert Gjati, Gjustina Loloci, Ardii Bardhi PP71 The comparison of sensitisation to animal allergens in children- and adult- onset patients with asthma Behnam Moghtaderi, Shirin Farjadian, Dorna Eghtedari PP72 Characterisation of children less than five years with wheezing episodes in Cali, Colombia Manuela Olaya, Laura Del Mar Vasquez, Luis Fernando Ramirez, Carlos Daniel Serrano PP73 Evaluation of the patients with recurrent croup Belgin Usta Guc, Suna Asilsoy, Fulya Ozer PP74 Obesity in adolescence compromising the asthma control Guergana Petrova, Sylvia Shopova, Vera Papochieva, Snezhina Lazova, Dimitrinka Miteva, Penka Perenovska PP75 Sleep behavior in children with persistent allergic rhinitis Gustavo F. Wandalsen, Jessica Loekmanwidjaja, Márcia Mallozi, Dirceu Solé PP76 Randomised trial of the safety of MP29-02* compared with fluticasone propionate nasal spray in children aged ≥4 years to <12 years with allergic rhinitis William Berger, Ulrich Wahn, Paul Ratner, Daniel Soteres PP77 Safety and tolerability evaluation of bilastine 10 mg in children from 2 to 11 years of age with allergic rhinoconjunctivitis or urticaria Zoltán Novák, Anahí Yáñez, Kiss Ildikó, Piotr Kuna, Miguel Tortajada, Román Valiente, the Bilastine Pediatric Safety Study Group PP78 Sensitisation to Alternaria alternata: Is it a risk factor for severe rhinitis? Susana Lopes, Filipa Almeida, Tânia Lopes, Cristina Madureira, José Oliveira, Fernanda Carvalho PP79 Validation of the Patient Benefit Index (PBI) for the assessment of patient-related outcomes in allergic rhinitis in children Julia Feuerhahn, Christine Blome, Meike Hadler, Efstrathios Karagiannis, Anna Langenbruch, Matthias Augustin PP80 Efficacy of sublingual tablet of house dust mite allergen extracts in adolescents with house dust mite-associated allergic rhinitis Michel Roux, Shinji Kakudo, Efstrathios Karagiannis, Robert K. Zeldin PP81 Lung function improvement in a child treated with omalizumab for bronchial asthma Anna Sokolova, Tiago Milheiro Silva PP82 How to treat a child suffering from asthma, allergic rhinitis, allergy to peanuts and diabetes at the same time? Snezana S. Zivanovic, Vesna Cvetkovic, Ivana Nikolic, Sonja J. Zivanovic PP83 Nitric oxide in exhaled air in the relationship of the degree of sensitisation to aeroallergens Snezana S. Zivanovic, Ljiljana Saranac, Ivana Nikolic, Sonja J. Zivanovic, Zorica Zivkovic PP84 Clinical basis of diagnostic errors in pediatric asthma Zoia Nesterenko PP85 PP86 Childhood asthma control in Serbia and organised Asthma Educational Intervention (AEI) Snezana Radic, Branislava Milenkovic, Spomenka Smiljanic, Milka Micic-Stanijevic, Olivera Calovic PP87 Experience from a group of adolescents with severe allergic asthma treated with Omalizumab Anne Marie Bro Hofbauer, Lone Agertoft THEMATIC POSTER SESSION 1: Prevention and Treatment—Epidemiology (TP01–TP18) TP01 A cost effective primary school asthma education program: pilot study from inner London schools Lucy Everson, Jessica Kearney, Jonny Coppel, Simon Braithwaite, Rahul Chodhari TP02 The prevalence of allergic diseases among 14–15 years old adolescents in two Danish birth cohorts 14 years apart Elisabeth S. Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Charlotte G. Mørtz, Susanne Halken TP03 Does pattern of sensitisation to phleum pratense change with age? Is it different in children with allergic rhinitis or asthma? Cristina Román India, Ana Moreira Jorge, Loreto González Domínguez, Cristina Muñoz Archidona, Sergio Quevedo Teruel, Teresa Bracamonte Bermejo, Juana Jiménez Jiménez, Luis Echeverría Zudaire TP04 Practicalities of prevention of peanut allergy: modelling a national response to LEAP Cathal O’Connor, Jonathan Hourihane TP05 Comparison of the influence of sunflower seed oil and skin care lotion on the skin barrier function of newborns: a randomised controlled trial Varvara Kanti, Lena Lünnemann, Günther Malise, Laine Ludriksone, Andrea Stroux, Wolfgang Henrich, Michael Abu-Dakn, Ulrike Blume-Peytavi, Natalie Garcia Bartels TP06 The effect of daily skin care on skin barrier properties in infants with dry skin and risk for atopic dermatitis Varvara Kanti, Lena Lünnemann, Laine Ludriksone, Marianne Schario, Andrea Stroux, Ulrike Blume-Peytavi, Natalie Garcia Bartels TP07 Change in sum total aeroallergen skin prick test wheal diameters at 6 months predicts which children will respond to subcutaneous immunotherapy by three years Thorsten Stanley, Nicolien Brandenbarg TP08 Are mobile apps regarding adrenaline auto-injectors accessed by adolescents for support and education in the community? Alia Boardman, Gary McGreevy, Emily Rodger, Katherine Knight, Victoria Timms, Trisha Taylor, Gemma Scanlan, Roisin Fitzsimons TP09 TP10 Prevention of early atopic dermatitis among low-atopy-risk infants by immunoactive prebiotics is not sustained after the first year of life Grüber Christoph, Ulrich Wahn, Margriet van Stuivenberg, Fabio Mosca, Guido Moro, Gaetano Chirico, Christian P. Braegger, Joseph Riedler, Yalcin Yavuz, Günther Boehm TP11 TP12 TP13 Treatment with Omalizumab in a 16-year-old Caucasian girl with refractory solar urticaria Stefania Arasi, Giuseppe Crisafulli, Lucia Caminiti, Federica Porcaro, Giovanni Battista Pajno TP14 Ultra-pure soft water ameliorates skin conditions of adult and child patients with atopic dermatitis Akane Tanaka, Yaei Togawa, Kumiko Oida, Naotomo Kambe, Peter Arkwright, Yosuke Amagai, Naoki Shimojo, Yasunori Sato, Hiroyuki Mochizuki, Hyosun Jang, Saori Ishizaka, Hiroshi Matsuda TP15 Potential adjuvant effect of immunomodulator to improve specific immunotherapy in asthmatic child Wisnu Barlianto, Ery Olivianto, H. M. S. Chandra Kusuma TP16 How can Component Resolved Diagnosis (CRD) influence in Specific Immunotherapy (SIT) prescription, in a Spanish children population Ana Moreira Jorge, Cristina Román India, Loreto González Domínguez, Cristina Muñoz Archidona, Juana Jiménez Jiménez, Teresa Bracamonte Bermejo, Sergio Quevedo Teruel, Luis Echeverría Zudaire TP17 Mitochondrial dysfunction in food allergy: effects of L. rhamnosus GG in a mice model of peanut allergy Rosita Aitoro, Mariapia Mollica, Roberto Berni Canani, Giovanna Trinchese, Elena Alfano, Antonio Amoroso, Lorella Paparo, Francesco Amato, Claudio Pirozzi, Antonio Calignano, Rosaria Meli TP18 Prediction of atopic diseases in childhood: elevated blood eosinophils in infancy in a high risk birth cohort Siri Rossberg, Kerstin Gerhold, Kurt Zimmermann, Mohammad Zaino, Thomas Geske, Eckard Hamelmann, Susanne Lau THEMATIC POSTER SESSION 2: Food allergy—Anaphylaxis (TP19–TP38) TP19 TP20 TP21 Double-blind provocation tests in non-IgE mediated cow’s milk allergy and the occurrence of placebo reactions Sarah Bogovic, Jochem van den Berg, Chantal Janssen TP22 Gradual introduction of baked egg (BE) in egg allergic patients under 2 years old Angela Claver TP23 Randomised controlled trial of SOTI with raw hen’s egg in children with persistent egg allergy I: safety and efficacy of daily vs. weekly protocols of induction Mª Flor Martin-Muñoz, C. Martorell, M. T. Belver, E. Alonso Lebrero, L. Zapatero, V. Fuentes, M. Piqué, A. Plaza, C. Muñoz, A. Martorell, Cristina Blasco, B. Villa, C. Gómez, S. Nevot, J. M. García, L. Echeverria TP24 Randomised controlled trial of SOTI with raw hen’s egg in children with persistent egg allergy II: a randomised controlled trial to study a safer, more effective and easy to perform maintenance (daily vs. every two days) pattern of egg SOTI Mª Flor Martin-Muñoz, C. Martorell, M. T. Belver, E. Alonso Lebrero, L. Zapatero, V. Fuentes, M. Piqué, A. Plaza, C. Muñoz, A. Martorell, Cristina Blasco, B. Villa, C. Gómez, S. Nevot, J. M. García, L. Echeverria TP25 Determining the safety of baked egg home reintroduction for children with mild egg allergy Brenda DeWitt, Judith Holloway, Donald Hodge TP26 Demographics, investigations and patterns of sensitisation in children with oral allergy syndrome in a London Teaching Hospital Sian Ludman, Merhdad Jafari-Mamaghani, Rosemary Ebling, Adam T. Fox, Gideon Lack, George Du Toit TP27 Airborne peanut challenge in children: allergic reactions are rare Sofia Lovén Björkman, Caroline Nilsson, Natalia Ballardini TP28 The nutty question on Pediatric Wards: to be or “nut” to be? Supriyo Basu, Jenny Hallet, Jyothi Srinivas TP29 TP30 TP31 Allergy education in nursery schools Hazel Stringer, Nicola Jay TP32 Food allergy in the first year of life Tânia Lopes, Cristina Madureira, Filipa Almeida, Susana Lopes, Paula Fonseca, Clara Vieira, Fernanda Carvalho TP33 Prevalence and geographic distribution of oral allergy syndrome in Italian children: a multicenter study Carla Mastrorilli, Carlo Caffarelli, Riccardo Asero, Salvatore Tripodi, Arianna Dondi, Gianpaolo Ricci, Carlotta Povesi Dascola, Elisabetta Calamelli, Francesca Cipriani, Andrea Di Rienzo Businco, Annamaria Bianchi, Paolo Candelotti, Tullio Frediani, Carmen Verga, Paolo Maria Matricardi TP34 Are common standardised allergen extracts used in skin test enough in the diagnosis of nuts allergy? Cristina Muñoz Archidona, Loreto González Domínguez, Ana Moreira Jorge, Sergio Quevedo Teruel, Teresa Bracamonte Bermejo, Miriam Castillo Fernández, Fernando Pineda de la Losa, Luis Ángel Echeverría Zudaire TP35 Evaluation of IgE sensitisation in children with allergic proctocolitis and its relationship to atopic dermatitis Despina Mermiri, Paraskevi Korovessi, Skevi Tiliakou, Evaggelia Tavoulari, Kalliopi-Maria Moraiti, Fotini Giannoula, Athina Papadopoulou TP36 Food allergy in children: are we managing them appropriately in the Emergency Department? Wan Jean Tee, Samir Deiratany, Raymond Seedhoo, Roisin McNamara, Ike Okafor TP37 Importance of oil body associated allergenic proteins in nuts suspected allergy children Loreto González Domínguez, Ana Moreira Jorge, Cristina Muñoz Archidona, Teresa Bracamonte Bermejo, Sergio Quevedo Teruel, Fernando Pineda de la Losa, Miriam Castillo Fernández, Luis Ángel Echeverría Zudaire TP38 Practical application of basophil activation test in children with food allergy Ekaterina Khaleva, Gennady Novic, Natalia Bychkova THEMATIC POSTER SESSION 3: Asthma (TP39–TP57) TP39 Effect of corticosteroid therapy upon serum magnesium level in chronic asthmatic children Amany Abd Al-Aziz, Amany Fatouh, Ayat Motawie, Eman El Bostany, Amr Ibrahim TP40 ADAM33 in Bulgarian children with asthma Guergana Petrova, Dimitrinka Miteva, Snezhina Lazova, Penka Perenovska, Sylvia Andonova, Alexey Savov TP41 TP42 The impact of vitamin D serum levels in asthma and allergic rhinitis Maria Zoto, Marialena Kyriakakou, Paraskevi Xepapadaki, Nikolaos G. Papadopoulos TP43 Life-threatening, first reported, paradoxical bronchospasm after nebulised Salbutamol in a 10 year old child Paraskevi Korovessi, Mariza Vassilopoulou, Athina Balaska, Lambros Banos, Stavroula Kostaridou, Despina Mermiri TP44 TP45 Asthma symptoms in children with treatment for allergic rhinoconjunctivitis Jorien Wartna, Arthur M. Bohnen, Gijs Elshout, David H. J. Pols, Patrick J. E. Bindels Erasmus MC, Rotterdam, The Netherlands TP46 Atopy increased the risk of developing exercise-induced bronchoconstriction in young athletes Sven F. Seys; Ellen Dilissen, Sarah Van der Eycken, An-Sofie Schelpe, Gudrun Marijsse, Thierry Troosters, Vincent Vanbelle, Sven Aertgeerts, Jan L. Ceuppens, Lieven J. Dupont, Koen Peers, Dominique M. Bullens TP47 The effect of higher BMI on risk for asthma and treatment outcome in overweight and obese children Ivana Banic, Sandra Bulat Lokas, Jelena Zivkovic, Boro Nogalo, Iva Mrkic Kobal, Davor Plavec, Mirjana Turkalj TP48 TP49 TP50 TP51 TP52 The impact of a multidisciplinary project intended to change the culture of nebulisers towards pressurised metered dose inhalers Georgeta Oliveira, Katharine Pike, Alda Melo, Tomás Amélia, José Carlos Cidrais Rodrigues, Cristina Serrano, José Manuel Lopes dos Santos, Carla Lopes TP53 TP54 TP55 TP56 Increased asthma control in patients with severe persistent allergic asthma after 12 month of nightly temperature controlled laminar airflow (TLA) Eckard Hamelmann, Uwe Schauer, Karl-Christian Bergmann TP57 THEMATIC POSTER SESSION 4: Drug allergy—Dermatology (TP58–TP77) TP58 Should we proceed directly to provocation challenges to diagnose drug allergy? Our experience says yes Luis Moral, Teresa Toral, Nuria Marco, Beléns García Avilés, Mª Jesús Fuentes, Jesús Garde, Cristina Montahud, Javier Perona, Mª José Forniés TP59 Anaphylaxis to 13-valent pneumococcal vaccine Esozia Arroabarren, Marta Anda, Maria Luisa Sanz, Maria Teresa Lizaso, Candida Arregui TP60 Intrapartum antibiotic exposure for treatment of group B streptococcus was not associated with the development of penicillin allergy in children Sara May, Martha Hartz, Avni Joshi, Miguel A. Park TP61 Evaluation of suspected drug hypersensitivity reactions in 169 children referred to the General Hospital Sonja Posega Devetak, Tina Vesel, Anja Koren Jeverica, Tadej Avčin TP62 Drug provocation testing: experience of a tertiary hospital Leonor Castro, Carolina Gouveia, Ana Carvalho Marques, Antonio Jorge Cabral TP63 Perioperative anaphylaxis: a growing concern in pediatric population Luis Amaral, Fabrícia Carolino, Eunice Castro, Madalena Passos, Josefina R. Cernadas TP64 Raising awareness of hypersensitivity to non-steroidal anti-inflammatory drugs in the pediatric age Fabrícia Carolino, Luís Amaral, Eunice Dias de Castro, Josefina R. Cernadas TP65 Perioperative anaphylaxis in young children: how to confirm the suspicion Josefina R. Cernadas, Fabrícia Carolino, Luís Amaral, Fernando Pineda, Armanda Gomes TP66 A case study of a child suspected to be penicillin allergic-digging deeper Katherine Knight, Roisin Fitzsimons, Helen Brough TP67 Prevalence, characteristics and risk factors of hypersensitivity reactions to antibiotics in patients with cystic fibrosis Jobst Röhmel, Carsten Schwarz, Anne Mehl, Philippe Stock, Doris Staab TP68 Antibiotic drug hypersensitivity in cystic fibrosis: A pilot study using cellular allergy tests for diagnostics Jobst Röhmel, Carsten Schwarz, Christine Seib, Doris Staab, Philippe Stock TP69 Oral antibiotics challenges in children Anita Critchlow, Alyson Barber, Nicola Jay TP70 Hypersensitivity reaction to vancomycin: a new successful desensitization protocol Belen Delavalle, Teresa Garriga, Blanca Vilá, Cristina Blasco TP71 TP72 Clinical phenotypes according to FLG gene loss of function mutations in children with atopic dermatitis Francesca Cipriani, Annalisa Astolfi, Costanza Di Chiara, Elisabetta Calamelli, Iria Neri, Annalisa Patrizi, Gianpaolo Ricci TP73 TP74 Urticaria in children: clinical and epidemiological features Katerina Neskorodova, Asya Kudryavtseva TP75 TP76 Acute urticaria at the Pediatrics Emergency Department: is it allergy? Esozia Arroabarren, Jorge Alvarez, Marta Anda, Miriam Palacios, Marta Martinez-Merino, Ibone Vaquero TP77
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- 2016
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161. Influence of cycle length variations on antitachycardia pacing effectiveness among ICD patients.
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Jiménez-Candil, Javier, Hernández, Jesús, Martín, Ana, Moríñigo, José, López, Rosana, Ledesma, Claudio, and Martín-Luengo, Cándido
- Abstract
Background: Antitachycardia pacing (ATP) fails to terminate 5% to 25% of ventricular tachycardias (VTs) occurring in implantable cardioverter-defibrillator patients. We speculated that small fluctuations in VT cycle length (CL) may be related to the efficacy of subsequent ATP. Objective: The purpose of this study was to determine the relationship between the R-R variations of the last 12 R-R intervals before ATP and the efficacy of the first ATP attempt. Methods: We studied 551 VTs (CL 329±35 ms) occurring in 67 patients. We also analyzed the percentage of variation (P-RR), which was calculated by dividing the mean difference between each R-R interval and the next one by the CL (×100), and the acceleration index (AI), which was calculated by dividing the CL of the first 6 R-R intervals by the CL of the next 6. Results: The effectiveness of the first ATP therapy was 81%, being higher in VTs with AI<1 (85% vs 64%; P<.001). After classifying the events according to the tertiles of P-RR, ATP efficiency was better in higher values of P-RR (VTs with AI<1): 99% (third tertile) vs 85% (second tertile) vs 76% (first tertile), P<.001; and for VTs with AI≥1: 94% vs 68% vs 42% (P<.001). By logistic regression, P-RR (%; odds ratio 2.37; P<.001), and AI<1 (odds ratio 4.17; P<.001) were found to be independent predictors of successful first ATP attempts. Conclusion: Small changes in CL increase the effectiveness of ATP significantly. VTs with lower degrees of R-R fluctuations, especially when the pattern is a progressive CL shortening, are infrequently terminated by ATP. [ABSTRACT FROM AUTHOR]
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- 2013
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162. Principios y reglas de solución aplicables a las controversias territoriales a la luz de la jurisprudencia de la Corte Internacional de Justicia.
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López Martín, Ana Gemma
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INTERNATIONAL relations ,INTERNATIONAL law ,ACTIONS & defenses (Law) ,TREATY accession ,UTI possidetis (International law) - Abstract
Copyright of Anuario Colombiano de Derecho Internacional is the property of Colegio Mayor de Nuestra Senora del Rosario and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2013
163. Quality of life in patients with smell loss due to upper respiratory tract infections.
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Toledano, Adolfo, Rodríguez, Gil, Martín, Ana María, Onrubia, Tomás, and Galindo, Néstor
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Abstract: Purpose: Upper respiratory tract infections (URTIs) are among the most frequent causes of dysosmias. It has been reported that acute anosmic patients often experience a feeling of personal isolation, display less interest in eating, and feel emotionally impaired. Our goal is to describe the quality of life (QOL) in patients with URTI olfactory loss. Material and Methods: A retrospective and descriptive patient-based study was performed. From 2002 to 2007, 51 patients with URTI olfactory loss (40 women [78.4%] and 11 men [21.6%]) were studied. The mean age was 53.3 ± 1.8 years. Olfactory function was assessed using the Connecticut Chemosensorial Clinical Research Center test. All patients completed the QOL questionnaire Rhinosinusitis Disability Index. The following were determined: total score; visual analogue scale from 1 to 10; and functional, emotional, and physical domains. Descriptive analysis and Mann-Whitney U nonparametric test were used. Results: Rhinosinusitis Disability Index data showed that questions f2, f4, p8, and p20 reached the highest score. The patients'' mean overall rating of the severity of olfactory impairment was 3.9 ± 2.8, which fell into the moderate category. Conclusions: The patients'' mean overall rating of the severity of olfactory impairment fell into the moderate category. The follow-up time span is important to assess the QOL of patients. [Copyright &y& Elsevier]
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- 2011
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164. Un indicador multidimensional de pobreza basado en la geometría euclídea.
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Fedriani, Eugenio M. and Martín, Ana M.
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EUCLIDEAN geometry ,POVERTY ,SOCIAL sciences ,HYPERPLANES ,ECONOMIC indicators ,POVERTY rate ,PRODUCTION (Economic theory) - Abstract
Copyright of Revista de Ciencias Sociales (13159518) is the property of Revista de Ciencias Sociales de la Universidad del Zulia Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2011
165. La visión del conocimiento científico y del conocimiento tecnológico en los libros de Química General utilizados en carreras de Ingeniería de la Universidad de Buenos Aires.
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Martín, Ana M., Barrero, Carmen, Sánchez, Lidia, and Cornejo, Jorge N.
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TEXTBOOKS ,CHEMISTRY ,SCIENTIFIC knowledge ,TECHNOLOGY education ,INDUSTRIAL chemistry ,TECHNOLOGICAL innovations - Abstract
Despite the diversity of media available today, the textbook is still the main educational resources used in science education, and its selection is one of the most important curricular decisions made by teachers. Moreover, due to the special characteristics of the engineering activities, it is necessary, from the start of the course, to resort to textbooks that strike a balance between scientific knowledge and technology. The purpose of this study is to determine the underlying beliefs present in textbooks. For that matter, twenty chemistry textbooks used at the School of Engineering of the University of Buenos Aires were analyzed. The textbooks were classified in two categories: those that reveal a relationship between scientific and technological knowledge, and those that adscribe to positivist, systemic or socio-historical backgrounds. The relationship between the two categories was analyzed. It was observed that most chemistry textbooks tend to ignore an explicit definition of technological knowledge. [ABSTRACT FROM AUTHOR]
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- 2011
166. The role of place identity and place attachment in breaking environmental protection laws.
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Hernández, Bernardo, Martín, Ana M., Ruiz, Cristina, and Hidalgo, del Carmen
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PLACE attachment (Psychology) ,ENVIRONMENTAL psychology ,ENVIRONMENTAL law ,ATTITUDE (Psychology) ,SOCIAL norms ,ENVIRONMENTAL protection ,ENVIRONMENTAL policy ,HUMAN behavior - Abstract
Abstract: Place identity and place attachment have been related to several environmental variables such as appropriation, residential satisfaction, physical care taken of the neighbourhood, restorativeness, environmental attitudes and, especially, pro-environmental behaviour. However, the role of place identity and place attachment has not been analyzed in relation to anti-ecological behaviours such as transgressions of environmental protection laws. The aim of this study is to analyze the relationship of place identity, place attachment and environmental attitudes to the personal and social norms that explain the likelihood of illegal behaviours against the environment. The sample was composed of men and women, aged from 19 to 70 years, who were resident in rural, urban or tourist areas of a territory under high environmental protection. The strongest predictor of environmental transgression is personal norms, whereas place identity and place attachment have no direct relation with future transgression or personal norms. Place identity influences environmental attitudes and social norms, which are both antecedents of personal norms. The results led us to reconsider the efficacy of interventions aimed at encouraging compliance with environmental laws by only emphasizing individuals'' bonds with the environment, and the need to extend the study of the role of personal and social norms in environmental protection. [Copyright &y& Elsevier]
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- 2010
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167. In-Hospital Prognosis in Non-ST-Segment Elevation Acute Coronary Syndrome Derived Using a New Risk Score Based on Electrocardiographic Parameters Obtained at Admission.
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Jiménez-Candil, Javier, González Matas, José Manuel, González, Ignacio Cruz, Hernández, Jesús Hernández, Martín, Ana, Pabón, Pedro, Martín, Francisco, and Martín-Luengo, Cándido
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ELECTROCARDIOGRAPHY ,HEART disease prognosis ,HOSPITAL admission & discharge ,HEART disease related mortality ,LOGISTIC regression analysis ,THROMBOLYTIC therapy ,MYOCARDIAL infarction risk factors - Abstract
Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2010
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168. The clonal composition of Mycobacterium tuberculosis in clinical specimens could be modified by culture.
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Martín, Ana, Herranz, Marta, Ruiz Serrano, María Jesús, Bouza, Emilio, and García de Viedma, Darío
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MYCOBACTERIUM tuberculosis ,BACTERIAL cultures ,DNA ,GENETIC engineering ,BACTERIAL diseases ,DISEASE susceptibility ,VOLUMETRIC analysis ,LUNG diseases - Abstract
Summary: Background: The application of molecular tools has revealed that infection by Mycobacterium tuberculosis (MTB) is more complex than initially assumed. Genotyping is generally performed on cultures. However, there is no information about bacterial clonal complexity in clinical specimens or whether standard culture procedures can modify this complexity. Methods: An in vitro assay was performed to determine whether culture can modify the clonal complexity of the MTB population in clinical specimens. Pairs of MTB strains (10 pairs) or stain-positive sputa (4 pairs) were mixed in different volumetric proportions. The DNA extracted from the mixtures before and after culture was genotyped using mycobacterial interspersed repetitive unit-variable-number tandem repeat analysis to detect potential changes in the proportion of the mixed strains. Results: In 6/10 pairs of MTB strains and 2/4 pairs of sputa, marked changes were observed in clonal composition after culture, even in mixtures of strains differing in their drug-susceptibility patterns. In some cases, only one of the mixed strains was detected after culture. Conclusions: The initial clonal composition in bacteriologically complex clinical specimens could be underestimated if genotyping analysis is performed after culture. Genotyping strategies aimed at analyzing clinical samples must be optimized to reveal the real dimension of clonal complexity in infection by MTB. [Copyright &y& Elsevier]
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- 2010
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169. Química Analítica: Una Oportunidad para la Inclusión de Aspectos Sociales y Culturales en Ingeniería Química.
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Martín, Ana M. and Speltini, Cristina
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CHEMICAL engineering ,ANALYTICAL chemistry ,INDUSTRIAL chemistry ,CHEMICAL engineers - Abstract
Copyright of Formación Universitaria is the property of Centro de Informacion Tecnologica (CIT) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2010
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- View/download PDF
170. LOS ESTADOS «FALLIDOS» Y SUS IMPLICACIONES EN EL ORDENAMIENTO JURÍDICO INTERNACIONAL.
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López Martín, Ana Gemma
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INTERNATIONAL obligations ,INTERNATIONAL security ,INTERNATIONAL organization - Abstract
Copyright of Cursos de Derecho Internacional y Relaciones Internacionales de Vitoria-Gasteiz is the property of Universidad del Pais Vasco, Servicio Editorial and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2010
171. INFLUENCIA DE LA TESTOSTERONA SOBRE LA INFECCIÓN CAUSADA POR TRYPANOSOMA CRUZI.
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Pérez, Ana Rosa, Pascutti, María Fernanda, Fontanella, Germán H., Martín, Ana P., Tartalini, Vanina, Nocito, Ana Lía, Berra, Héctor H., Pezzotto, Stella M., Romano, Marta C., and Revelli, Silvia S.
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Copyright of Revista Médica de Rosario is the property of Circulo Medico de Rosario and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
172. Transcatheter tricuspid annuloplasty with the Cardioband device to treat severe functional tricuspid regurgitation.
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Sánchez-Recalde, Ángel, Hernández-Antolín, Rosana, Salido Tahoces, Luisa, García-Martín, Ana, Fernández-Golfín, Covadonga, and Zamorano, José L.
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- 2020
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173. Diagnóstico diferencial de las lesiones anulares eritematosas en el recién nacido
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Rodríguez Martín, Ana María and Vélez García-Nieto, Antonio
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- 2014
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174. Rotura uterina espontánea durante el segundo trimestre asociado a placenta pércreta. Caso clínico y revisión de la literatura
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Lago Leal, Víctor, Martínez Cortés, Luis, López Martín, Ana Belén, Ocaña Martínez, Vanesa, Muñoz Fernández, Teresa, Ruiz Sierra, Alexandra Yamile, and Martín Hita, Ana María
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Caso de rotura uterina por placenta pércreta confirmado histológicamente a las 20 semanas de gestación y revisión bibliográfica de casos clínicos publicados de menos de 28 semanas.
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- 2014
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175. Prevalencia del trastorno negativista desafiante en España.
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López-Villalobos, José Antonio, Andrés-De Llano, Jesús María, Rodríguez-Molinero, Luis, Garrido-Redondo, Mercedes, Sacristán-Martín, Ana María, Martínez-Rivera, María Teresa, Alberola-López, Susana, and Sánchez-Azón, María Isabel
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Resumen: Introducción: El trastorno negativista desafiante (TND) se caracteriza por un patrón de comportamiento negativista, desafiante, desobediente y hostil, dirigido a las figuras de autoridad. El TND es uno de los motivos más frecuentes de consulta clínica en salud mental durante la infancia y adolescencia. Presenta gran morbilidad y disfuncionalidad, mostrando repercusiones futuras si no es tratado de forma temprana. Objetivo: Determinar la tasa de prevalencia de TND en escolares de 6-16 años de Castilla y León (España). Material y métodos: Estudio epidemiológico poblacional, con diseño muestral polietápico estratificado, proporcional y por conglomerados. Muestra analizada: 1.049 sujetos. Casos definidos según criterios DSM-IV. Resultados: La prevalencia de TND es 5,6% (IC 95%: 4,2-7%). Prevalencia género masculino=6,8%; femenino=4,3%. Prevalencia educación secundaria=6,2%; educación primaria=5,3%. No existen diferencias significativas en función del sexo, edad, tipo de centro, ni por zona sociodemográfica. La prevalencia de TND sin considerar deterioro funcional aumentaría al 7,4%. Los casos de TND presentan significativamente peores resultados académicos (resultados académicos globales, lectura, matemáticas y expresión escrita) y peor conducta en clase (relación con compañeros, respeto a las normas, destrezas de organización, realización de tareas académicas e interrupción de la clase). Conclusiones: Castilla y León presenta una tasa de prevalencia de TND levemente superior a la observada en publicaciones internacionales. En función de su distribución por edad, morbilidad y repercusión clínica disfuncional, parece necesaria una planificación sanitaria que incida en un diagnóstico temprano e intervención preventiva. [Copyright &y& Elsevier]
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- 2014
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176. Infant, primary and secondary teachers’ conceptions of learning and teaching and their relation to educational variables
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Martín, Elena, Pozo, Juan Ignacio, Mateos, Mar, Martín, Ana, and Pérez Echeverría, María del Puy
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It has been established that teachers’ conceptions of learning and teaching influence their instructional practices. Several authors maintain that these conceptions are based on certain implicit assumptions that give rise to different theories. Our view is that people have multiple alternative theories which they use depending on the context and the demands of the task. The main purpose of this study was to find out whether such representational plurality exists in teachers’ conceptions and, if it does, whether this plurality can lead to the identification of different representational profiles. We were also interested in studying some of the teaching practice variables that might influence the nature of the representational profiles. Our results, obtained by means of a dilemma questionnaire answered by 1074 teachers from different educational levels and knowledge domains and with different ranges of experience, are consistent with the assumption of representational plurality, as they show that the same teacher may hold different conceptions that set up a conceptions profile. Moreover, the combination of the responses in each profile is not random. Teachers at the more advanced levels and with more teaching experience manifested more traditional conceptions. Furthermore, some knowledge domains were associated with certain conception profiles.
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- 2014
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177. Estado y gestión emocional de los pacientes afectados por la COVID-19 en un centro de salud
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Peral Martín, Ana, Cabezas García, María, and Martínez Sáez, Óscar
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- 2021
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178. Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion
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Isern, Joan, Martín-Antonio, Beatriz, Ghazanfari, Roshanak, Martín, Ana M., López, Juan A., del Toro, Raquel, Sánchez-Aguilera, Abel, Arranz, Lorena, Martín-Pérez, Daniel, Suárez-Lledó, María, Marín, Pedro, Van Pel, Melissa, Fibbe, Willem E., Vázquez, Jesús, Scheding, Stefan, Urbano-Ispizúa, Álvaro, and Méndez-Ferrer, Simón
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Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that recapitulate their natural microenvironment, such as bone marrow stromal stem/progenitor cells (BMSCs). Plastic-adherent BMSCs may be insufficient to preserve primitive HSCs. Here, we describe a method of isolating and culturing human BMSCs as nonadherent mesenchymal spheres. Human mesenspheres were derived from CD45−CD31−CD71−CD146+CD105+nestin+cells but could also be simply grown from fetal and adult BM CD45−-enriched cells. Human mesenspheres robustly differentiated into mesenchymal lineages. In culture conditions where they displayed a relatively undifferentiated phenotype, with decreased adherence to plastic and increased self-renewal, they promoted enhanced expansion of cord blood CD34+cells through secreted soluble factors. Expanded HSCs were serially transplantable in immunodeficient mice and significantly increased long-term human hematopoietic engraftment. These results pave the way for culture techniques that preserve the self-renewal of human BMSCs and their ability to support functional HSCs.
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- 2013
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179. Impact of COVID-19 on a brain damage unit.
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Romero, Juan Pablo, Bravo-Martín, Ana, Oliva-Navarrete, Paulina, Sánchez-Cuesta, Francisco, Ríos-Lago, Marcos, and Benito-León, Julián
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To report on the impact of COVID-19 on a brain damage unit. We reviewed the records of all patients admitted to our brain damage unit. The study included all the significant clinical events from the first positive qualitative real-time reverse-transcriptase–polymerase-chain-reaction assay (April 8th, 2020) for SARS-CoV-2 to the day all patients tested negative (June 8th, 2020). Of the 20 patients (14 men) (age 57.7 ± 14.9; 2–71 months after brain damage; all with a modified Rankin scale score > 4), 16 tested positive for SARS-CoV-2 and remained positive for a mean of 32.3 days (ranging from 26 to 61). One patient died from COVID-19, while 12 patients were asymptomatic and three suffered mild pneumonia without acute respiratory distress syndrome. All patients received prophylactic subcutaneous heparin. Intravenous methylprednisolone was prescribed for three patients with bilateral pneumonia with excellent results. Most positive cases (93.7%) were not severe. The good outcome was most likely due to the use of prophylactic anticoagulation therapy, the early use of methylprednisolone for pneumonia and the previously reported immunosuppression amid patients with brain damage. This study hopes to encourage further study into brain damage immunity. • Most the positive cases did not have a severe disease and most of the symptomatic patients did not have a poor outcome. • The good outcome could be related to anticoagulation therapy, methylprednisolone and prevailing immunosuppressed state. • Further studies on immune-modulatory effects of brain damage are required. [ABSTRACT FROM AUTHOR]
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- 2021
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180. Fenofibrate administration to arthritic rats increases adiponectin and leptin and prevents oxidative muscle wasting
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Castillero, Estíbaliz, Martín, Ana Isabel, Nieto-Bona, Maria Paz, Fernández-Galaz, Carmen, López-Menduiña, María, Villanúa, María Ángeles, and López-Calderón, Asunción
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Chronic inflammation induces skeletal muscle wasting and cachexia. In arthritic rats, fenofibrate, a peroxisome proliferator-activated receptor α (PPARα (PPARA)) agonist, reduces wasting of gastrocnemius, a predominantly glycolytic muscle, by decreasing atrogenes and myostatin. Considering that fenofibrate increases fatty acid oxidation, the aim of this study was to elucidate whether fenofibrate is able to prevent the effect of arthritis on serum adipokines and on soleus, a type I muscle in which oxidative metabolism is the dominant source of energy. Arthritis was induced by injection of Freund's adjuvant. Four days after the injection, control and arthritic rats were gavaged daily with fenofibrate (300 mg/kg bw) or vehicle over 12 days. Arthritis decreased serum leptin, adiponectin, and insulin (P<0.01) but not resistin levels. In arthritic rats, fenofibrate administration increased serum concentrations of leptin and adiponectin. Arthritis decreased soleus weight, cross-sectional area, fiber size, and its PparαmRNA expression. In arthritic rats, fenofibrate increased soleus weight, fiber size, and Pparαexpression and prevented the increase in Murf1mRNA. Fenofibrate decreased myostatin, whereas it increased MyoD(Myod1) and myogenin expressions in the soleus of control and arthritic rats. These data suggest that in oxidative muscle, fenofibrate treatment is able to prevent arthritis-induced muscle wasting by decreasing Murf1and myostatin expression and also by increasing the myogenic regulatory factors, MyoD and myogenin. Taking into account the beneficial action of adiponectin on muscle wasting and the correlation between adiponectin and soleus mass, part of the anticachectic action of fenofibrate may be mediated through stimulation of adiponectin secretion.
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- 2012
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181. Plasma Ribavirin Trough Concentrations During Treatment of Chronic Hepatitis C in Genotype-1 Patients
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de-Rueda, Paloma Muñoz-, Ruiz-Extremera, Angeles, Candel, Jose M., Quiles, Rosa, Martín, Ana Belen, Diago, Moises, Andrade, Raul, Navarro, Jose M., Gila, Ana, León, Josefa, Carazo, Angel, Quintero, Dolores, and Salmerón, Javier
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To investigate the correlation between virological response and plasma ribavirin trough concentrations (RBV Ctrough) during the full period of chronic hepatitis C (CHC) treatment.
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- 2012
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182. Quorum-Sensing and BvrR/BvrS Regulation, the Type IV Secretion System, Cyclic Glucans, and BacA in the Virulence of Brucella ovis: Similarities to and Differences from Smooth Brucellae
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Martín-Martín, Ana I., Sancho, Pilar, de Miguel, María Jesús, Fernández-Lago, Luis, and Vizcaíno, Nieves
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ABSTRACTBrucella ovisis a rough bacterium—lacking O-polysaccharide chains in the lipopolysaccharide—that is virulent in its natural host and whose virulence mechanisms remain almost unexplored. In a search for additional traits that distinguish B. ovisfrom smooth Brucella, which require O-polysaccharide chains for virulence, we have analyzed the significance in B. ovisof the main virulence factors described for smooth Brucella. Attempts to obtain strains of virulent B. ovisstrain PA that are mutated in the BvrR/BvrS two-component regulatory system were unsuccessful, suggesting the requirement of that system for in vitrosurvival, while the inactivation of bacA—in contrast to the results seen with smooth Brucella—did not affect splenic colonization in mice or behavior in J774.A1 murine macrophages. Defects in the synthesis of cyclic ß-1,2 glucans reduced the uptake of B. ovisPA in macrophages and, although the intracellular multiplication rate was unaffected, led to attenuation in mice. Growth of strains with mutations in the type IV secretion system (encoded by the virBoperon) and the quorum-sensing-related regulator VjbR was severely attenuated in the mouse model, and although the mutant strains internalized like the parental strain in J774.A1 murine macrophages, they were impaired for intracellular replication. As described for B. melitensis, VjbR regulates the transcription of the virBoperon positively, and the N-dodecanoyl-dl-homoserine lactone (C12-HSL) autoinducer abrogates this effect. In contrast, no apparent VjbR-mediated regulation of the fliFflagellar gene was observed in B. ovis, probably due to the two deletions detected upstream of fliF. These results, together with others reported in the text, point to similarities between rough virulent B. ovisand smooth Brucellaspecies as regards virulence but also reveal distinctive traits that could be related to the particular pathogenicity and host tropism characteristics of B. ovis.
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- 2012
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183. Factors Associated With Hepatic Steatosis in Obese Children and Adolescents
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Ruiz-Extremera, Ángeles, Carazo, Ángel, Salmerón, Ángela, León, Josefa, Casado, Jorge, Goicoechea, Alejandro, Fernandez, José Manuel, Garofano, Maximiliano, Ocete, Esther, Martín, Ana Belén, Pavón, Esther, and Salmerón, Javier
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Obesity is associated with high prevalence of hepatic steatosis. We speculate that determinant factors of susceptibility to hepatic steatosis in obesity could differ between children and adolescents. Blood biochemical parameters, systemic oxidative stress markers, proinflammatory cytokines, and adipokine levels were determined in 157 obese children and adolescents. The subjects were divided into 2 groups: children and adolescents, identified as such in accordance with Tanner stage and the measured level of dehydroepiandrosterone sulphate. Steatosis was evaluated by ultrasonography in 127 subjects. Steatosis prevalence was 44.8%. In the “children” group, those with hepatic steatosis presented higher levels of erythrocyte oxidised glutathione (GSSG) and resistin, lower levels of high-density lipoprotein (HDL) cholesterol, and lower enzymatic activities of erythrocyte glutathione reductase (GRd) and glutathione oxidase (GPx). In the “adolescents” group, those with hepatic steatosis presented higher values for body mass index zscore (BMIz), insulin, peptide C, homeostatic model assessment index (HOMA-IR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides, GSSG, and leptin. These subjects also presented lower values for soluble leptin receptor, GRd, and GPx. In the “children” group, the only independent factor of steatosis was a decrease in GRd activity (odds ratio [OR] 0.165, 95% CI 0.03–0.84, P= 0.030). Moreover, in the “adolescent” group, the independent factors were higher for GSSG (OR 6.8, 95% CI 1.6–28.7, P= 0.010) and HOMA-IR (OR 1.9, 95% CI 1.17–3.1, P= 0.009). Factors associated with hepatic steatosis differ between obese children and adolescents. Oxidative stress is seen to be the main process in children, whereas in adolescents oxidative stress and insulin resistance are significant factors for steatosis.
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- 2011
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184. ¿Utilizan las personas legas las mismas categorías de transgresiones medioambientales que las administraciones públicas?
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Martín, Ana M., Hess, Stephany, Alonso, Isabel, and Frías-Armenta, Martha
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Las transgresiones medioambientales son quebrantamientos de las leyes de protección medioambiental (LPMA) que constituyen una forma peculiar de comportamiento ilegal desde un punto de vista jurídico y psicosocial. Las LPMA incluyen comportamientos muy variados, tan distintos entre sí como para requerir criterios de valoración diferentes. En este estudio se analizaron las respuestas de 196 estudiantes universitarios, residentes en un territorio de alta protección medioambiental, a un cuestionario compuesto por 20 transgresiones medioambientales habituales en su contexto inmediato, que debían valorar en 14 escalas. Los resultados mostraron que las dimensiones del espacio perceptivo de los participantes son consistentes con las obtenidas con otras muestras, episodios, escalas y procedimientos estadísticos. Estas dimensiones permitieron clasificar correctamente un 85% de las transgresiones en relación a tres categorías utilizadas habitualmente por la Administración pública, siendo la predicción más acertada para las transgresiones contra el medio natural que para la contaminación y las actividades constructivas.
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- 2011
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185. Do lay people classify environmental transgressions in the same way as public administrations?
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Martín, Ana M., Hess, Stephany, Alonso, Isabel, and Frías-Armenta, Martha
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Environmental transgressions involve breaking environmental protection laws (EPL), constituting a singular kind of illegal conduct from a legal and psychosocial perspective. EPL encompass a wide variety of behaviours which is very broad-ranging and, therefore, require different evaluation criteria. This study analyzes the responses of 196 university students living in an area of high environmental protection to a questionnaire encompassing 20 common environmental transgressions in their immediate surroundings, which they had to evaluate using 14 scales. The results show that the dimensions of the participants' perceptive space are consistent with those obtained through other samples, episodes, scales and statistical procedures. These dimensions enabled 85% of transgressions to be correctly classified into the three categories commonly used by public administrations, with more accurate predictions found for Transgressions against the Natural Environment than for Pollution/Contamination and Construction Activities.
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- 2011
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186. Evaluation of the Inaccurate Assignment of Mixed Infections by Mycobacterium tuberculosisas Exogenous Reinfection and Analysis of the Potential Role of Bacterial Factors in Reinfection
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Martín, Ana, Herranz, Marta, Navarro, Yurena, Lasarte, Sandra, Ruiz Serrano, María Jesús, Bouza, Emilio, and García de Viedma, Darío
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ABSTRACTMolecular analysis of recurrent tuberculosis has revealed that a second episode may be caused by a strain of Mycobacterium tuberculosisother than that involved in the first infection, thus indicating that exogenous reinfection plays a role in recurrence. We focused on two aspects of reinfection that have received little attention. First, we evaluated whether a lack of methodological refinement could lead to inaccurate assignment of mixed infections as exogenous reinfection, in which a differential selection of each of the coinfecting strains occurred over time. We used the mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) method to genotype 122 isolates from 40 patients with recurrent tuberculosis. We identified 11/40 (27.5%) cases with genotypic differences between the isolates involved in the sequential episodes. Major genotypic differences were found in 8/11 cases, suggesting exogenous reinfection; in the remaining 3 cases, subtle genotypic differences were observed, probably indicating microevolution from a parental strain. In all cases, only a single strain was detected for the isolate(s) from each episode, thus ruling out the possibility that reinfection could correspond to undetected mixed infection. Second, we analyzed the infectivity of a selection of 12 strains from six cases with genotypically different strains between episodes. No main differences were observed in an ex vivomodel of infection between the strains involved in the first episodes and those involved in the recurrent episodes. In our setting, our results suggest the following: (i) the possibility of misassignment of mixed infection as exogenous reinfection is improbable, and (ii) bacterial infectivity does not seem to play a role in exogenous reinfection.
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- 2011
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187. Papel de Atención Primaria en el cáncer de mama
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Diego, Isabel Alonso, González-Gallego, Sagrario Pinilla, Gonzalo, Alicia Fernández, Alonso Martín, Ana M., Gómez, Mercedes Camino, and de Castro, Francisco López
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describir las actividades relacionadas con la atención al cáncer de mama (CM) y el papel de Atención Primaria (AP) en dicho proceso.
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- 2010
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188. Risk Factors for Fluconazole-Resistant Candidemia
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Garnacho-Montero, José, Díaz-Martín, Ana, García-Cabrera, Emilio, Ruiz Pérez de Pipaón, Maite, Hernández-Caballero, Clara, Aznar-Martín, Javier, Cisneros, José M., and Ortiz-Leyba, Carlos
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ABSTRACTPrevious studies have sought to determine the risk factors associated with candidemia caused by non-albicans Candidaspp. or with potentially fluconazole-resistant Candidaspp. (C. glabrataand C. krusei). Non-albicans Candidastrains are a heterogeneous group that includes species with different levels of virulence, and only a limited number of C. glabrataisolates are resistant to fluconazole. We set out to identify the risk factors associated with microbiologically proven fluconazole-resistant candidemia. A prospective study including adult patients with candidemia was performed. Data were collected on patient demographics; underlying diseases; exposure to corticosteroids, antibiotics, or fluconazole; and invasive procedures. Risk factors associated either with non-albicans Candidaspp. or potentially fluconazole-resistant Candidaspp. (C. glabrataor C. krusei) or with Candidaspp. with microbiologically confirmed fluconazole resistance were assessed using logistic regressions. We included 226 candidemia episodes. Non-albicans Candidaisolates accounted for 53.1% of the fungal isolates, but only 18.2% of the cases were caused by potentially fluconazole-resistant organisms. Thirty isolates exhibited microbiologically confirmed fluconazole resistance. The multivariate analysis revealed that independent predictors associated with fluconazole-resistant Candidaspp. were neutropenia (odds ratio [OR] = 4.94; 95% confidence interval [CI] = 1.50 to 16.20; P= 0.008), chronic renal disease (OR = 4.82; 95% CI = 1.47 to 15.88; P= 0.01), and previous fluconazole exposure (OR = 5.09; 95% CI = 1.66 to 15.6; P= 0.004). Independently significant variables associated with non-albicans Candidabloodstream infection or with potentially fluconazole-resistant Candidaspp. did not include previous fluconazole exposure. We concluded that prior fluconazole treatment is an independent risk factor only for candidemia caused by microbiologically confirmed fluconazole resistant species. Our findings may be of value for selecting empirical antifungal therapy.
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- 2010
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189. Pronóstico hospitalario del síndrome coronario agudo sin elevación del segmento ST determinado por una nueva escala de riesgo integrada por variables electrocardiográficas obtenidas al ingreso
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Jiménez-Candil, Javier, Matas, José Manuel González, González, Ignacio Cruz, Hernández, Jesús Hernández, Martín, Ana, Pabón, Pedro, Martín, Francisco, and Martín-Luengo, Cándido
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Diferentes variables electrocardiográficas tienen capacidad predictiva en el síndrome coronario agudo sin elevación del ST (SCASEST). Tras analizar a 427 pacientes, construimos una escala de riesgo (ER) basada en el ECG al ingreso (ER-ECG) para definir la probabilidad de muerte o isquemia recurrente (M-IsqR) durante la hospitalización, que fue del 36%. En un análisis de regresión logística que incluyó siete variables electrocardiográficas y las de la ER TIMI, alcanzaron la significación estadística: QTc ≥ 450 ms (odds ratio[OR] = 4,2; p < 0,001); descenso del ST > 0,5 (OR = 2,7; p < 0,001) y crecimiento auricular izquierdo (OR = 1,8; p = 0,005). En función de la OR, se otorgó 3 puntos a QTc ≥ 450 ms, 2 a descenso del ST > 0,5 mm y 1 a crecimiento auricular izquierdo. Agrupando a los pacientes según la ER-ECG en: ≤ 1, 2-3, ≤ 4, ésta discriminó adecuadamente la probabilidad de M-IsqR: el 11 frente al 27 frente al 58% (p < 0,001). Por lo tanto, esta ER-ECG permite estratificar el pronóstico del SCASEST de una forma simple, rápida y precisa.
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- 2010
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190. Ultra-short celiac disease exhibits differential genetic and immunophenotypic features compared to conventional celiac disease
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Mata-Romero, Pilar, Martín-Holgado, Daniel, Ferreira-Nossa, Hal C., González-Cordero, Pedro L., Izquierdo-Martín, Ana, Barros-García, Patricia, Fernandez-Gonzalez, Nuria, Fernández-Pereira, Luis, Cámara-Hijón, Carmen, and Molina-Infante, Javier
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Ultra-short coeliac disease (USCD) is a novel celiac disease (CD) subtype limited to the duodenal bulb (D1). HLA haplotypes and flow cytometry have not been assessed yet.
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- 2022
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191. Recomendaciones para la transfusión de hemoderivados en neonatología
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Boix, Hector, Sánchez-Redondo, María Dolores, Cernada, María, Espinosa Fernández, María Gracia, González-Pacheco, Noelia, Martín, Ana, Pérez-Muñuzuri, Alejandro, and Couce, María L.
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La escasa evidencia sobre el uso de las transfusiones en neonatología explica las limitaciones de las guías clínicas actuales. A pesar de ello, en este documento analizamos la evidencia más reciente para hacer unas recomendaciones para la práctica clínica. La prevención de la anemia de la prematuridad, el uso de protocolos y las indicaciones restrictivas de transfusión, componen la mejor estrategia para nuestros clínicos. En las transfusiones de plaquetas, es preciso valorar el riesgo de sangrado, integrando la situación clínica y analítica. Por último, el plasma fresco congelado está recomendado en neonatos con coagulopatía y sangrado activo, en déficits congénitos de factores sin tratamiento específico y en situaciones de coagulación intravascular diseminada. Todos los hemoderivados presentan efectos adversos que deben hacernos evaluar individual y minuciosamente la necesidad de una transfusión.
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- 2022
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192. Unilateral mydriasis during temporal lobe seizures
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García‐Martín, Ana M., Molina‐Martínez, Francisco J., Amer‐Ferrer, Guiem, Sureda‐Ramis, Bernat, Moreno‐Rojas, Antonio J., and Barceló‐Artigues, Inés
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Autonomic signs and symptoms are a common feature of epileptic seizures. Although sympathetic activation responses are predominant, we can also find sympathetic inhibition and even an activation of the parasympathetic division of the autonomic nervous system, especially in partial seizures. These autonomic symptoms during seizures are thought to be the result of neuronal discharges arising from or spreading to cortical areas of the central autonomic network. Mydriasis, most commonly bilateral, is one of the most frequent findings. The patient described, a middle‐aged man with a focal lesion in the right temporal lobe extended to the adjacent hypothalamus, presented with episodes of autonomic symptoms including prominent unilateral mydriasis, finally evolving into a state of decreased alertness. An ictal electroencephalogram and a simultaneous video recording supported the clinical impression of an epileptic aetiology. Unilateral mydriasis is a rare condition during epileptic seizures and very few cases have been reported in the past. [Published with video sequences] Content available: Video
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- 2008
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193. The Sequential Analysis of Transgressors' Accounts of Breaking Environmental Laws
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Martín, Ana M., Salazar-Laplace, María Esther, and Ruiz, Cristina
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Three-hundred and twenty written accounts of environmental transgressors were assessed by sequential analysis to reveal their argument streams. The accounts were obtained from the written statements that transgressors are allowed to give during the Spanish administrative process and which were included in files handled by four environmental law enforcement agencies. These agencies are distributed across national, regional, island and municipality jurisdictions. The setting for the study is a highly protected environment in which environmental laws have high salience. Results reveal that transgressors use simple argument streams, consistently more defensive than conciliatory, and questioning the perceived legitimacy of environmental law. It was seen also that the empirical functioning of the explanations related to pursuing emotional/prosocial objectives differs from what was expected from the traditional conceptual definition. Results are discussed in terms of how the assessment of the internal dynamic of the accounts would provide valuable information on transgressors' reasoning in relation to environmental laws.
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- 2008
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194. Role of the Omp25/Omp31 Family in Outer Membrane Properties and Virulence of Brucella ovis
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Caro-Hernández, Paola, Fernández-Lago, Luis, de Miguel, María-Jesús, Martín-Martín, Ana I., Cloeckaert, Axel, Grilló, María-Jesús, and Vizcaíno, Nieves
- Abstract
The genes coding for the five outer membrane proteins (OMPs) of the Omp25/Omp31 family expected to be located in the outer membrane (OM) of rough virulent Brucella ovis PA were inactivated to evaluate their role in virulence and OM properties. The OM properties of the mutant strains and of the mutants complemented with the corresponding wild-type genes were analyzed, in comparison with the parental strain and rough B. abortus RB51, in several tests: (i) binding of anti-Omp25 and anti-Omp31 monoclonal antibodies, (ii) autoagglutination of bacterial suspensions, and (iii) assessment of susceptibility to polymyxin B, sodium deoxycholate, hydrogen peroxide, and nonimmune ram serum. A tight balance of the members of the Omp25/Omp31 family was seen to be essential for the stability of the B. ovis OM, and important differences between the OMs of B. ovis PA and B. abortus RB51 rough strains were observed. Regarding virulence, the absence of Omp25d and Omp22 from the OM of B. ovis PA led to a drastic reduction in spleen colonization in mice. While the greater susceptibility of the omp22 mutant to nonimmune serum and its difficulty in surviving in the stationary phase might be on the basis of its dramatic attenuation, no defects in the OM able to explain the attenuation of the omp25d mutant were found, especially considering that the fully virulent omp25c mutant displayed more important OM defects. Accordingly, Omp25d, and perhaps Omp22, could be directly involved in the penetration and/or survival of B. ovis inside host cells. This aspect, together with the role of Omp25d and Omp22 in the virulence both of B. ovis in rams and of other Brucella species, should be thoroughly evaluated in future studies.
- Published
- 2007
195. La utilidad de la ecografía clínica ante la sospecha de fascitis necrosante
- Author
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Tung-Chen, Yale, Algora Martín, Ana, and Romero Gallego-Acho, Paloma
- Published
- 2020
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196. Anuloplastia tricuspídea percutánea con dispositivo Cardioband para el tratamiento de la insuficiencia funcional tricuspídea grave
- Author
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Sánchez-Recalde, Ángel, Hernández-Antolín, Rosana, Salido Tahoces, Luisa, García-Martín, Ana, Fernández-Golfín, Covadonga, and Zamorano, José L.
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- 2020
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197. Nitric oxide production by hepatocytes contributes to the inhibitory effect of endotoxin on insulin-like growth factor I gene expression
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Priego, Teresa, Granado, Miriam, Castillero, Estibaliz, Martín, Ana Isabel, Villanúa, M Ángeles, and López-Calderón, Asunción
- Abstract
We tested whether endotoxin (lipopolysaccharide, LPS) inhibits IGF-I gene expression in hepatocytes and the possible role of Kupffer cells and nitric oxide (NO) in this effect. LPS decreased IGF-I mRNA in hepatocyte cultures and increased the nitrite + nitrate levels in the culture medium. Furthermore, there was a negative correlation between the IGF-I mRNA and the nitrite+nitrate levels. When hepatocytes were cocultured with Kupffer cells, the inhibitory effect of LPS on IGF-I mRNA was higher than in hepatocyte cultures, but the stimulatory effect on nitrite+nitrate was similar in both conditions. The exogenous NO donated by S-nitroso-n-acetyl-d,l-penicillamide also decreased the IGF-I gene expression in hepatocyte cultures. In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. These data indicate that iNOS-derived NO may cause downregulation of IGF-I gene expression in hepatocytes. However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS-induced decrease in IGF-I gene expression. We conclude that in hepatocytes, LPS-induced decrease in IGF-I is mainly due to induction of iNOS, whereas in the presence of Kupffer cells LPS inhibits IGF-I through NO release and through other inhibitory pathways.
- Published
- 2006
- Full Text
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198. Molecular characterization of Haemophilus parasuis ferric hydroxamate uptake (fhu) genes and constitutive expression of the FhuA receptor
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Río, Maria MLd del, Navas, Jesús JN, Martín, Ana AJM, Gutiérrez, César CBG, Barbosa, José JIR Rodríguez, and Ferri, Elías EFR Rodríguez
- Abstract
Bacteria have evolved a set of highly specialized proteins to capture iron in iron-depleted environments. The acquisition and uptake of iron present in the extracellular milieu of eukaryotic organisms is indispensable for the growth and survival of microbial pathogens in the course of infection. Haemophilus parasuis is the causative agent of Glässer disease, which is responsible for considerable financial losses in pig-rearing worldwide. To gain insight into the mechanisms involved in siderophore-mediated iron uptake in H. parasuis, genes in the H. parasuis ferric hydroxamate uptake (Fhu) region were amplified in the work being reported here. As has been described in A. pleuropneumoniae, an Fhu genomic region was also present in H. parasuis, being composed of four potential consecutive open reading frames (ORF) designated as fhuC, fhuD, fhuB, and fhuA, respectively. By immunoblotting, using a cross-reactive polyclonal antibody raised against Actinobacillus pleuropneumoniae FhuA protein, it was demonstrated that this protein was constitutively expressed in H. parasuis and its level of expression was not modified under conditions of restricted iron availability. This is the first report describing the presence of the fhu genes in H. parasuis. Our results indicate that FhuA protein expression is not affected under iron-restricted conditions, however, it is one of the targets of the humoral immune response.
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- 2006
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199. Dexamethasone administration attenuates the inhibitory effect of lipopolysaccharide on IGF-I and IGF-binding protein-3 in adult rats
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Priego, Teresa, Granado, Miriam, Martín, Ana Isabel, López-Calderón, Asunción, and Villanúa, María Angeles
- Abstract
The aim of this study was to investigate whether glucocorticoid administration had a beneficial effect on serum concentrations of insulin-like growth factor I (IGF-I) and on IGF-binding protein 3 (IGFBP-3) in rats injected with lipopolysaccharide (LPS). Adult male rats were injected with LPS or saline and pretreated with dexamethasone or saline. Dexamethasone administration decreased growth hormone (GH) receptor and IGF-I mRNA levels in the liver of control rats. LPS decreased GH receptor and IGF-I gene expression in the liver of saline-treated rats but not in the liver of dexamethasone-pretreated rats. In the kidney, GH receptor mRNA levels were not modified by dexamethasone or LPS treatment. However, LPS decreased renal IGF-I gene expression and dexamethasone pretreatment prevented this decrease. Serum concentrations of IGF-I were decreased by LPS, and dexamethasone pretreatment attenuated this effect. The gene expression of IGFBP-3 in the liver and kidney and its circulating levels were decreased by LPS. In control rats dexamethasone increased circulating IGFBP-3 and its gene expression in the liver, and decreased the proteolysis of this protein. Dexamethasone pretreatment attenuated the LPS-induced decrease in IGFBP-3 gene expression in the liver and prevented the LPS-induced decrease in IGFBP-3 gene expression in the kidney. Moreover, dexamethasone pretreatment attenuated the LPS-induced decrease in serum concentrations of IGFBP-3 and decreased the LPS-induced IGFBP-3 proteolysis in serum. In conclusion, dexamethasone pretreatment partially attenuates the inhibitory effect of LPS on serum IGF-I by blocking the decrease of its gene expression in the kidney as well as by attenuating the decrease in serum concentrations of IGFBP-3.
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- 2005
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200. Simpson Jacobians of reducible curves
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López-Martín, Ana Cristina
- Abstract
For any projective curve X let M¯d (X) be the Simpson moduli space of pure dimension one rank 1 degree d sheaves that are semistable with respect to a fixed polarization H on X. When X is a reduced curve the connected component of M¯d (X ) that contains semistable line bundles can be considered as the compactified Jacobian of X. In this paper we give explicitly the structure of this compactified Simpson Jacobian for the following projective curves: tree-like curves and all reduced and reducible curves that can appear as Kodaira singular fibers of an elliptic fibration, that is, the fibers of types III, IV and IN with N ? 2.
- Published
- 2005
- Full Text
- View/download PDF
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