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Exploring individual hallmarks of brain ageing is important. Here, we propose the age-related glucose metabolism pattern (ARGMP) as a potential index to characterize brain ageing in cognitively normal (CN) elderly people. We collected (18)F-fluorodeoxyglucose ((18)F-FDG) PET brain images from two independent cohorts: the Alzheimer’s Disease Neuroimaging Initiative (ADNI, N = 127) and the Xuanwu Hospital of Capital Medical University, Beijing, China (N = 84). During follow-up (mean 80.60 months), 23 participants in the ADNI cohort converted to cognitive impairment. ARGMPs were identified using the scaled subprofile model/principal component analysis method, and cross-validations were conducted in both independent cohorts. A survival analysis was further conducted to calculate the predictive effect of conversion risk by using ARGMPs. The results showed that ARGMPs were characterized by hypometabolism with increasing age primarily in the bilateral medial superior frontal gyrus, anterior cingulate and paracingulate gyri, caudate nucleus, and left supplementary motor area and hypermetabolism in part of the left inferior cerebellum. The expression network scores of ARGMPs were significantly associated with chronological age (R = 0.808, p

I analyze institutions of prison subculture that mitigate potential violent confrontations among inmates, in contrast to Hobbesian-Zimbardo default spontaneous violence. The games that are relatively rarely played in prison are Chicken and other violent confrontation games. Incoming rookie inmates are subject to initiation tests that allocate them into different subcultural groups, which signals their toughness and disincentivizes fighting. Most experienced inmates develop the eristic skills utilizing prison argot, use informal conflict adjudicators, and fake aggression toward rookies. All inmates form defensive coalitions. Finally, when inmates commit self-injuries, they follow well-rehearsed protocols to minimize the damage to their bodies and to maximize the impression made on the authorities. The secret knowledge of the associated rules, tricks, and cons is passed down over generations of prisoners through informal schooling. The material for this study comes from two Polish prisons, where the author spent 5 months as a political prisoner in 1985.

International audience; The reaction of [Re(CO)3(THF)(μ-Br)]2 or [Re(CO)5X] (X = Cl, Br, I) with the diaryl-2-azabutadienes [(RS)2C[double bond, length as m-dash]C(H)–N[double bond, length as m-dash]CAr2] containing two thioether arms at the 4,4-position forms the luminescent S,N-chelate complexes fac-[(OC)3ReX{(RS)2C[double bond, length as m-dash]C(H)–N[double bond, length as m-dash]CAr2}] (1a–h). The halide abstraction by silver triflate converts [(OC)3ReCl{(PhS)2C[double bond, length as m-dash]C(H)–N[double bond, length as m-dash]CPh2}] (1c) to [(OC)3Re(OS([double bond, length as m-dash]O)2CF3){(PhS)2C[double bond, length as m-dash]C(H)–N[double bond, length as m-dash]CPh2}] (1j) bearing a covalently bound triflate ligand. The cyclic voltammograms reveal reversible S^N ligand-centred reduction and irreversible oxidation waves for all complexes. The crystal structures of nine octahedral complexes have been determined along with that of (NaphtylS)2C[double bond, length as m-dash]C(H)–N[double bond, length as m-dash]CPh2 (L6). A rich system of weak non-covalent intermolecular secondary interactions through CH⋯X(Cl, Br)Re, CH⋯O, CO⋯π(Ph), CH⋯πCO, CH⋯O and CH⋯S contacts has been evidenced. The photophysical properties have been investigated by steady-state and time-resolved absorption (fs transient absorption, fs-TAS) and emission (ns-TCSPC and ps-Streak camera) spectroscopy in 2-MeTHF solution at 298 and 77 K. The emission bands are composed of either singlet (450 < λmax < 535 nm) and/or triplet emissions (at 77 K only, λmax < 640 nm, or appearing as a tail at λ > 600 nm), which decay in a multiexponential manner for the fluorescence (short ps (i.e.

The ruling party in Turkey, the AKP, made an ex post mistake by changing the electoral law before the parliamentary elections in 2018. The new apparentement provision allowed parties to make electo...

Since the beginnings of modern Arabic and Islamic studies in the West in 19th century, there exist a paradigm saying that the “Ottoman Period” (16-19 c.) in the history of Arabic culture and literature did not bring any interesting works, thoughts, ideas and personalities in the Middle East and especially in the North Africa. Nevertheless the last investigations provided as by Arabic as by Western scholars shows that this is not the truth. The achievements of this period are sometimes unexpected. In this context I would like to present shortly three 19th century Moroccan writers, whose output is almost completely neglected by the Orientalists. They are a poet and politician Ibn Idris al-‘Amrawi (1794?-1864), a historian and poet Muhammad al-Kansusi(1796-1877) and a writer and historian Ahmad an-Nasiri (1835-1897). Their literary output is little known in the West, while in Morocco they are treated as most outstanding writers in modern literary history of this country.

Background: Diabetes mellitus (DM) is known to contribute to unfavorable short- and long-term outcomes in patients with myocardial infarction (MI). Particularly poor outcomes are associated with left ventricular systolic dysfunction after an MI. The aim of our study was to compare the short- and long-term outcomes of MI in patients with DM and varied degrees of left ventricular systolic dysfunction with the corresponding outcomes in a non-diabetic control group. Methods: This analysis focused on patients with MI registered in the Polish National Registry of Acute Coronary Syndrome between 2009 and 2011. For the purposes of this analysis, diabetic patients were additionally stratified into three subgroups depending on the degree of left ventricular systolic dysfunction, as assessed during their hospitalization for MI. Subsequently, the 30-day, 12-month, and 36-month outcomes in the diabetic study subgroups were compared with those in the corresponding non-diabetic subgroups. Results: This analysis encompassed a nationwide cohort of 58,123 patients. 12- and 36- months mortality was greater in diabetic patients than in non-diabetic patients. The highest 36-month mortality (46.64%) was in the group of patients with DM and reduced EF < 40%. Multivariate analysis showed diabetes and low EF to be independent risk factors for 36-month mortality, increasing the risk of death by 35% for diabetes and by 30% for each 5-percentage point EF decrease. Higher mortality was observed in older patients, smokers, and patients with ischemic heart disease prior to the index hospitalization. Conclusions: Both diabetes and reduced EF proved to be independent risk factors for increased mortality over long-term follow-up after MI.

The quantum Kibble-Zurek mechanism (QKZM) predicts universal dynamical behavior near the quantum phase transitions (QPTs). It is now well understood for the one-dimensional quantum matter. Higher-dimensional systems, however, remain a challenge, complicated by the fundamentally different character of the associated QPTs and their underlying conformal field theories. In this work, we take the first steps toward theoretical exploration of the QKZM in two dimensions for interacting quantum matter. We study the dynamical crossing of the QPT in the paradigmatic Ising model by a joint effort of modern state-of-the-art numerical methods, including artificial neural networks and tensor networks. As a central result, we quantify universal QKZM behavior close to the QPT. We also note that, upon traversing further into the ferromagnetic regime, deviations from the QKZM prediction appear. We explain the observed behavior by proposing an {\it extended QKZM} taking into account spectral information as well as phase ordering. Our work provides a testing platform for higher-dimensional quantum simulators., Comment: 12 pages, 7 figures