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811 results on '"Magnani, Corrado"'

152. Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure.

Author

Magnani, Corrado, Silvestri, Stefano, Angelini, Alessia, Ranucci, Alessandra, Azzolina, Danila, Cena, Tiziana, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Bauleo, Lisa, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, and Oddone, Enrico

Published
2020
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153. Mortality and mesothelioma incidence among chrysotile asbestos miners in Balangero, Italy: A cohort study.

Author

Ferrante, Daniela, Mirabelli, Dario, Silvestri, Stefano, Azzolina, Danila, Giovannini, Andrea, Tribaudino, Patrizia, and Magnani, Corrado

Subjects
ASBESTOS, POISSON regression, CANCER-related mortality, LUNG cancer, PERITONEAL cancer
Abstract

Background: We studied cancer mortality and mesothelioma incidence in 974 male workers employed at least 6 months at the Balangero mine (Italy), the largest chrysotile mine in Western Europe, active from 1917 to 1985. Methods: Vital status as of 31 May 2013, causes of deaths and mesothelioma incidence from 1990 were ascertained. Past exposure to asbestos by working area and calendar period was estimated, based on historical data of fibers concentrations. Individual cumulative exposure was assessed by applying estimates to the job history of cohort members. Standardized mortality ratios (SMRs) for selected causes and standardized incidence ratios for malignant mesothelioma (MM) were calculated based on regional reference rates. Poisson regression analysis was used to study MM and lung cancer risk by latency, duration, and cumulative exposure. Results: Mortality was increased for all causes (SMR = 1.28; 95% confidence interval [CI] = 1.17‐1.40), pleural cancer (SMR = 4.30; 95% CI = 1.58‐9.37), asbestosis (SMR = 375.06; 95% CI = 262.68‐519.23). An increase was also found for lung cancer (SMR = 1.14; 95% CI = 0.81‐1.55) and peritoneal cancer (SMR = 3.25; 95% CI = 0.39‐11.75). The risk of both pleural and peritoneal cancer mortality and of mesothelioma incidence increased with increasing cumulative exposure, duration, and latency. Poisson regression analyses showed an increase in mesothelioma risk with cumulative asbestos exposure and suggest a similar trend for lung cancer. Asbestosis mortality also increased with cumulative exposure. Conclusions: Among Balangero chrysotile miners and millers, the occurrence of malignant and nonmalignant asbestos‐related diseases was increased by exposure, with dose‐response relation. The study confirms the carcinogenicity of chrysotile asbestos, in particular for pleural mesothelioma. [ABSTRACT FROM AUTHOR]

Published
2020
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154. Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes

Author

Betti, Marta, primary, Aspesi, Anna, additional, Ferrante, Daniela, additional, Sculco, Marika, additional, Righi, Luisella, additional, Mirabelli, Dario, additional, Napoli, Francesca, additional, Rondón-Lagos, Milena, additional, Casalone, Elisabetta, additional, Vignolo Lutati, Francesca, additional, Ogliara, Paola, additional, Bironzo, Paolo, additional, Gironi, C. Laura, additional, Savoia, Paola, additional, Maffè, Antonella, additional, Ungari, Silvana, additional, Grosso, Federica, additional, Libener, Roberta, additional, Boldorini, Renzo, additional, Valiante, Michele, additional, Pasini, Barbara, additional, Matullo, Giuseppe, additional, Scagliotti, Giorgio, additional, Magnani, Corrado, additional, and Dianzani, Irma, additional

Published
2018
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155. HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes

Author

Wang, Sophia S., primary, Carrington, Mary, additional, Berndt, Sonja I., additional, Slager, Susan L., additional, Bracci, Paige M., additional, Voutsinas, Jenna, additional, Cerhan, James R., additional, Smedby, Karin E., additional, Hjalgrim, Henrik, additional, Vijai, Joseph, additional, Morton, Lindsay M., additional, Vermeulen, Roel, additional, Paltiel, Ora, additional, Vajdic, Claire M., additional, Linet, Martha S., additional, Nieters, Alexandra, additional, de Sanjose, Silvia, additional, Cozen, Wendy, additional, Brown, Elizabeth E., additional, Turner, Jennifer, additional, Spinelli, John J., additional, Zheng, Tongzhang, additional, Birmann, Brenda M., additional, Flowers, Christopher R., additional, Becker, Nikolaus, additional, Holly, Elizabeth A., additional, Kane, Eleanor, additional, Weisenburger, Dennis, additional, Maynadie, Marc, additional, Cocco, Pierluigi, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J., additional, Teras, Lauren R., additional, Diver, W. Ryan, additional, Lax, Stephanie J., additional, Travis, Ruth C., additional, Kaaks, Rudolph, additional, Riboli, Elio, additional, Benavente, Yolanda, additional, Brennan, Paul, additional, McKay, James, additional, Delfau-Larue, Marie-Hélène, additional, Link, Brian K., additional, Magnani, Corrado, additional, Ennas, Maria Grazia, additional, Latte, Giancarlo, additional, Feldman, Andrew L., additional, Doo, Nicole Wong, additional, Giles, Graham G., additional, Southey, Melissa C., additional, Milne, Roger L., additional, Offit, Kenneth, additional, Musinsky, Jacob, additional, Arslan, Alan A., additional, Purdue, Mark P., additional, Adami, Hans-Olov, additional, Melbye, Mads, additional, Glimelius, Bengt, additional, Conde, Lucia, additional, Camp, Nicola J., additional, Glenn, Martha, additional, Curtin, Karen, additional, Clavel, Jacqueline, additional, Monnereau, Alain, additional, Cox, David G., additional, Ghesquières, Hervé, additional, Salles, Gilles, additional, Bofetta, Paulo, additional, Foretova, Lenka, additional, Staines, Anthony, additional, Davis, Scott, additional, Severson, Richard K., additional, Lan, Qing, additional, Brooks-Wilson, Angela, additional, Smith, Martyn T., additional, Roman, Eve, additional, Kricker, Anne, additional, Zhang, Yawei, additional, Kraft, Peter, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, Hartge, Patricia, additional, and Skibola, Christine F., additional

Published
2018
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158. The Length of SNCA Rep1 Microsatellite May Influence Cognitive Evolution in Parkinson’s Disease

Author

Corrado, Lucia, primary, De Marchi, Fabiola, additional, Tunesi, Sara, additional, Oggioni, Gaia Donata, additional, Carecchio, Miryam, additional, Magistrelli, Luca, additional, Tesei, Silvana, additional, Riboldazzi, Giulio, additional, Di Fonzo, Alessio, additional, Locci, Clarissa, additional, Trezzi, Ilaria, additional, Zangaglia, Roberta, additional, Cereda, Cristina, additional, D’Alfonso, Sandra, additional, Magnani, Corrado, additional, Comi, Giacomo P., additional, Bono, Giorgio, additional, Pacchetti, Claudio, additional, Cantello, Roberto, additional, Goldwurm, Stefano, additional, and Comi, Cristoforo, additional

Published
2018
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159. Immunohistochemistry and molecular diagnostics of pleural malignant mesothelioma

Author

Betta, Pier-Giacomo, Magnani, Corrado, Bensi, Thea, Trincheri, Nicol Francesca, and Orecchia, Sara

Subjects
Antigen-antibody reactions, Tumors, Immunohistochemistry, Mesothelioma, Health
Abstract

* Context.--The pathologic approach to pleural-based lesions is stepwise and uses morphologic assessment, correlated with clinical and imaging data supplemented by immunohistochemistry (IHC), and more recently, molecular tests, as an aid for 2 main diagnostic problems: malignant mesothelioma (MM) versus other malignant tumors and malignant versus reactive mesothelial proliferations. Objective.--To present the current knowledge regarding IHC and molecular tests with respect to MM diagnosis, and in particular, the differentiation of the epithelioid type of MM from carcinoma metastatic to the pleural cavity. Data Sources.--A review of immunohistochemical features of 286 consecutive MMs from 459 cases of pleural pathology, diagnosed during routine practice from 2003 to 2009. A survey of biomedical journal literature from MedLine/PubMed (US National Library of Medicine) focused on MM and associated tissue-based diagnostic IHC markers and molecular tests. Conclusions.--The search for a single diagnostic marker of MM has so far been discouraging, given the biologic and phenotypic tumor heterogeneity of MM. The use of antibody panels has gained unanimous acceptance especially in the differential diagnosis between MM and metastatic carcinoma, whereas the usefulness of IHC is more limited when dealing with spindle cell malignancies or distinguishing malignant from reactive mesothelium. A great degree of interlaboratory variability in antibody combinations and clone selection within diagnostic panels still exists. Current investigations aim at selecting the most suitable and cost-effective combination of antibodies by using novel statistical approaches for assessing diagnostic performance beyond the traditional measures of sensitivity and specificity. (Arch Pathol Lab Med. 2012; 136:253-261; doi: 10.5858/arpa.2010-0604-RA), Malignant mesothelioma (MM) is characterized by a heterogeneous morphologic phenotype that frequently overlaps with benign mesothelial proliferations or nonmesothelial tumors involving the serosal membranes. Therefore, it is not the rule [...]

Published
2012
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162. Comments on: Further studies of Bolivian crocidolite-Part IV: Fibre width, fibre drift and their relation to mesothelioma induction: Preliminary findings, by Ilgren EB, van Order DR, Lee RJ, Kamiya YM, Hoskins JA Epidemiology Biostatistics and Public Health 2015; 12 (2), e11167

Author

Magnani, Corrado, Barone Adesi, Francesco, Biggeri, Annibale, Comba, Pietro, Dalmasso, Paola, Marsili, Daniela, Maule, MILENA MARIA, Merletti, Franco, Mirabelli, Dario, Pasetto, Roberto, and Terracini, Benedetto

Subjects
Epidemiology, Health Policy, Public Health, Environmental and Occupational Health, Community and Home Care, Environmental and Occupational Health, Public Health
Published
2016

163. New versus Conventional Helmet for Delivering Noninvasive Ventilation: A Physiologic, Crossover Randomized Study in Critically Ill Patients

Author

Olivieri, Carlo, Longhini, Federico, Cena, Tiziana, Cammarota, Gianmaria, Vaschetto, Rosanna, Messina, Antonio, Berni, Paola, Magnani, Corrado, Della Corte Francesco, and Navalesi, P

Subjects
Adult, Male, Cross-Over Studies, Noninvasive Ventilation, Critical Care, Critical Illness, Humans, Female, Head Protective Devices, Equipment Design, Prospective Studies, Middle Aged, Aged
Abstract

The helmet is a well-tolerated interface for noninvasive ventilation, although it is associated with poor patient-ventilator interaction. A new helmet (NH) has proven to attenuate this limitation of the standard helmet (SH) in both bench study and healthy volunteers. The authors compared a NH and a SH in intensive care unit patients receiving noninvasive ventilation for prevention of postextubation respiratory failure; both helmets were also compared with the endotracheal tube in place before extubation.Fourteen patients underwent 30-min trials in pressure support during invasive ventilation and then with a SH and a NH in a random order. The authors measured comfort, triggering delays, rates of pressurization (airway pressure-time product [PTP] of the first 300 [PTP(300-index)] and 500 [PTP(500-index)] ms from the onset of effort, and the first 200 ms from the onset of insufflation [PTP200]), time of synchrony between effort and assistance (Time(synch)/Ti(neu)), respiratory drive and frequency, arterial blood gases (ABGs), and rate of asynchrony.Compared with SH, NH improved comfort (5.5 [5.0 to 6.0] vs. 8.0 [7.8 to 8.0]), respectively, P0.001), inspiratory trigger delay (0.31 [0.22 to 0.43] vs. 0.25 [0.18 to 0.31] s, P = 0.007), and pressurization (PTP(300-index): 0.8 [0.1 to 1.8] vs. 2.7 [7.1 to 10.0]%; PTP(500-index): 4.8 [2.5 to 9.9] vs. 27.3 [16.2 to 34.8]%; PTP200: 13.6 [10.1 to 19.6] vs. 30.4 [24.9 to 38.4] cm H2O/s, P0.01 for all comparisons) and Time(synch)/Ti(neu) (0.64 [0.48 to 0.72] vs. 0.71 [0.61 to 0.81], P = 0.007). Respiratory drive and frequency, ABGs, and rate of asynchrony were not different between helmets. Endotracheal tube outperformed both helmets with respect to all variables, except for respiratory rate, ABGs, and asynchronies.Compared with a SH, a NH improved comfort and patient-ventilator interaction.

Published
2016

164. Parental Tobacco Smoking and Acute Myeloid Leukemia The Childhood Leukemia International Consortium

Author

Metayer, Catherine Petridou, Eleni Mejia Arangure, Juan Manuel and Roman, Eve Schuz, Joachim Magnani, Corrado Maria Mora, Ana Mueller, Beth A. Pombo de Oliveira, Maria S. Dockerty, John D. McCauley, Kathryn Lightfoot, Tracy Hatzipantelis, Emmanouel Rudant, Jeremie Flores-Lujano, Janet Kaatsch, Peter Miligi, Lucia Wesseling, Catharina Doody, David R. and Moschovi, Maria Orsi, Laurent Mattioli, Stefano Selvin, Steve Kang, Alice Y. Clavel, Jacqueline MIGICCL Grp

Abstract

The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age < 15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2.08, 95% confidence interval (CI): 1.20, 3.61) but not in other ethnic groups. By contrast, the odds ratios for paternal lifetime smoking were 1.34 (95% CI: 1.11, 1.62) and 1.18 (95% CI: 0.92, 1.51) in pooled and meta-analyses, respectively. Overall, increased risks from 1.2- to 1.3-fold were observed for pre- and postnatal smoking (P < 0.05), with higher risks reported for heavy smokers. Associations with paternal smoking varied by histological type. Our analyses suggest an association between paternal smoking and childhood AML. The association with maternal smoking appears limited to Hispanic children, raising questions about ethnic differences in tobacco-related exposures and biological mechanisms, as well as study-specific biases.

Published
2016

165. Socioeconomic status and survival from soft-tissue sarcomas: a population-based study in northern Italy

Author

Ciccone, Giovannio, Magnani, Corrado, Delsedime, Luisa, and Vineis, Paolo

Subjects
Mortality -- Economic aspects, Sarcoma -- Patient outcomes, Cancer -- Italy, Sarcoma -- Care and treatment, Cancer -- Prognosis, Social status -- Health aspects, Government, Health care industry
Abstract

Soft-tissue sarcomas (STS) include cancers that arise from connective tissue, and typically affect areas of the body such as the breast or colon. The five-year survival rate in the US for these cancers is around 60 percent. Previous studies have noted variation in survival rates that were associated with socioeconomic status (SES). This study examined the relationship between SES and STS survival in residents of northern Italy. The study reviewed the long-term outcome of STS diagnosed in residents in the area between January 1, 1981 and December 31, 1983. During this time period, 86 residents were diagnosed with STS; an analysis of the SES of the subjects was also performed. Results showed that 57 percent of the subjects were alive three years after diagnosis. Subjects with less education and those who were unskilled workers had poorer survival rates than other subjects. When data was adjusted for factors such as age and sex, level of education was related to survival. These results indicate that length of survival for STS is related to SES. Although the exact reasons for this are not clear, it is probably associated with earlier diagnosis and access to treatment for people of higher SES. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

166. Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy

Author

Magnani, Corrado, primary, Ranucci, Alessandra, additional, Badaloni, Chiara, additional, Cesaroni, Giulia, additional, Ferrante, Daniela, additional, Miligi, Lucia, additional, Mattioli, Stefano, additional, Rondelli, Roberto, additional, Bisanti, Luigi, additional, Zambon, Paola, additional, Cannizzaro, Santina, additional, Michelozzi, Paola, additional, Cocco, Pierluigi, additional, Celentano, Egidio, additional, Assennato, Giorgio, additional, Merlo, Domenico Franco, additional, Mosciatti, Paola, additional, Minelli, Liliana, additional, Cuttini, Marina, additional, Torregrossa, Maria Valeria, additional, Lagorio, Susanna, additional, Haupt, Riccardo, additional, Forastiere, Francesco, additional, Magnani, Corrado, additional, Farioli, Andrea, additional, Salvan, Alberto, additional, Masera, Giuseppe, additional, Rizzari, Carmelo, additional, Greco Veneto, Alessandra, additional, Gafà, Lorenzo, additional, Luzzatto, Lia Lidia, additional, Benvenuti, Alessandra, additional, Kirchmayer, Ursula, additional, Galassi, Claudia, additional, Guarino, Erni, additional, de Nichilo, Gigliola, additional, Bocchini, Vittorio, additional, Chiavarini, Manuela, additional, Casotto, Veronica, additional, Valenti, Rosaria Maria, additional, Risica, Serena, additional, Polichetti, Alessandro, additional, Bochicchio, Francesco, additional, Nuccetelli, Cristina, additional, Biddau, Pierfranco, additional, Aricò, Maurizio, additional, DeSalvo, Gian Luca, additional, Locatelli, Franco, additional, Pession, Andrea, additional, Varotto, Stefania, additional, Poggi, Vincenzo, additional, Massaglia, Pia, additional, Monetti, Daniele, additional, Targhetta, Roberto, additional, Bernini, Gabriella, additional, Pannelli, Franco, additional, Sampietro, Giuseppe, additional, Schilirò, Gino, additional, Pulsoni, Alessandro, additional, and Parodi, Stefano, additional

Published
2016
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168. Comment on Piscitelli et al. Hospitalizations in Pediatric and Adult Patients for All Cancer Type in Italy: The EPIKIT Study under the E.U. COHEIRS Project on Environment and Health. Int. J. Environ. Res. Public Health 2017, 14, 495

Author

Terracini, Benedetto, primary, Alessi, Daniela, additional, Isaevska, Elena, additional, Macerata, Vanda, additional, Magnani, Corrado, additional, Manasievska, Milena, additional, Maule, Milena, additional, Merletti, Franco, additional, Mosso, Maria, additional, Rosso, Tiziana, additional, and Sacerdote, Carlotta, additional

Published
2017
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172. The Role of SNCA Rep1 Microsatellite in Parkinson’s Disease Progression

Author

Corrado, Lucia, primary, De Marchi, Fabiola, additional, Tunesi, Sara, additional, Oggioni, Gaia, additional, Carecchio, Miryam, additional, Magistrelli, Luca, additional, Tesei, Silvana, additional, Riboldazzi, Giulio, additional, Di Fonzo, Alessio, additional, Locci, Clarissa, additional, Trezzi, Ilaria, additional, Zangaglia, Roberta, additional, Cereda, Cristina, additional, D'Alfonso, Sandra, additional, Magnani, Corrado, additional, Giacomo Pietro, Comi, additional, Bono, Giorgio, additional, Pacchetti, Claudio, additional, Cantello, Roberto, additional, Goldwurm, Stefano, additional, and Comi, Cristoforo, additional

Published
2017
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175. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N. Wheeler, William A. Yeager, Meredith and Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov and Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. and Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner and Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. and Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie and Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine and Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen and Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing and Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu and Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song and Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores and Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. and Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia and Connors, Joseph M. Conti, David Cortessis, Victoria K. and Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. and Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria and Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Jr., Joseph F. and Freedman, Neal D. Freeman, Laura E. Beane Fuchs, Charles and Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang and Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina and Gascoyne, Randy D. Gastier-Foster, Julie Gaudet, Mia M. and Gaziano, J. Michael Giffen, Carol Giles, Graham G. and Giovannucci, Edward Glimelius, Bengt Goggins, Michael and Gokgoz, Nalan Goldstein, Alisa M. Gorlick, Richard Gross, Myron Grubb, III, Robert Gu, Jian Guan, Peng Gunter, Marc Guo, Huan Habermann, Thomas M. Haiman, Christopher A. and Halai, Dina Hallmans, Goran Hassan, Manal Hattinger, Claudia He, Qincheng He, Xingzhou Helzlsouer, Kathy and Henderson, Brian Henriksson, Roger Hjalgrim, Henrik and Hoffman-Bolton, Judith Hohensee, Chancellor Holford, Theodore R. and Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. and Horn-Ross, Pamela L. Hosain, G. M. Monawar Hosgood, III, H. Dean and Hsiao, Chin-Fu Hu, Nan Hu, Wei Hu, Zhibin Huang, Ming-Shyan Huerta, Jose-Maria Hung, Jen-Yu Hutchinson, Amy and Inskip, Peter D. Jackson, Rebecca D. Jacobs, Eric J. and Jenab, Mazda Jeon, Hyo-Sung Ji, Bu-Tian Jin, Guangfu and Jin, Li Johansen, Christoffer Johnson, Alison Jung, Yoo Jin and Kaaks, Rudolph Kamineni, Aruna Kane, Eleanor Kang, Chang Hyun Karagas, Margaret R. Kelly, Rachel S. Khaw, Kay-Tee and Kim, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk and Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kitahara, Cari M. Klein, Alison P. Klein, Robert J. Kogevinas, Manolis and Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles and Kricker, Anne Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. Kweon, Sun-Seog LaCroix, Andrea Lawrence, Charles and Lecanda, Fernando Lee, Victor Ho Fun Li, Donghui Li, Haixin and Li, Jihua Li, Yao-Jen Li, Yuqing Liao, Linda M. and Liebow, Mark Lightfoot, Tracy Lim, Wei-Yen Lin, Chien-Chung and Lin, Dongxin Lindstrom, Sara Linet, Martha S. Link, Brian K. Liu, Chenwei Liu, Jianjun Liu, Li Ljungberg, Boerje Lloreta, Josep Di Lollo, Simonetta Lu, Daru Lund, Eiluv Malats, Nuria Mannisto, Satu Le Marchand, Loic and Marina, Neyssa Masala, Giovanna Mastrangelo, Giuseppe and Matsuo, Keitaro Maynadie, Marc Mckay, James McKean-Cowdin, Roberta Melbye, Mads Melin, Beatrice S. Michaud, Dominique S. Mitsudomi, Tetsuya Monnereau, Alain Montalvan, Rebecca and Moore, Lee E. Mortensen, Lotte Maxild Nieters, Alexandra and North, Kari E. Novak, Anne J. Oberg, Ann L. Offit, Kenneth and Oh, In-Jae Olson, Sara H. Palli, Domenico Pao, William and Park, In Kyu Park, Jae Yong Park, Kyong Hwa and Patino-Garcia, Ana Pavanello, Sofia Peeters, Petra H. M. and Perng, Reury-Perng Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer and Prokunina-Olsson, Ludmila Qian, Biyun Qiao, You-Lin Rais, Marco Riboli, Elio Riby, Jacques Risch, Harvey A. and Rizzato, Cosmeri Rodabough, Rebecca Roman, Eve Roupret, Morgan Ruder, Avima M. de Sanjose, Silvia Scelo, Ghislaine and Schned, Alan Schumacher, Fredrick Schwartz, Kendra and Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol and Serra, Massimo Sesso, Howard D. Setiawan, Veronica Wendy and Severi, Gianluca Severson, Richard K. Shanafelt, Tait D. and Shen, Hongbing Shen, Wei Shin, Min-Ho Shiraishi, Kouya and Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sihoe, Alan Dart Loon Skibola, Christine F. Smith, Alex Smith, Martyn T. and Southey, Melissa C. Spinelli, John J. Staines, Anthony and Stampfer, Meir Stern, Marianna C. Stevens, Victoria L. and Stolzenberg-Solomon, Rachael S. Su, Jian Su, Wu-Chou Sund, Malin Sung, Jae Sook Sung, Sook Whan Tan, Wen Tang, Wei and Tardon, Adonina Thomas, David Thompson, Carrie A. and Tinker, Lesley F. Tirabosco, Roberto Tjonneland, Anne and Travis, Ruth C. Trichopoulos, Dimitrios Tsai, Fang-Yu Tsai, Ying-Huang Tucker, Margaret Turner, Jenny Vajdic, Claire M. and Vermeulen, Roel C. H. Villano, Danylo J. Vineis, Paolo and Virtamo, Jarmo Visvanathan, Kala Wactawski-Wende, Jean Wang, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wei, Fusheng Weiderpass, Elisabete Weiner, George J. Weinstein, Stephanie Wentzensen, Nicolas White, Emily Witzig, Thomas E. and Wolpin, Brian M. Wong, Maria Pik Wu, Chen Wu, Guoping and Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Xu, Ping and Yang, Pan-Chyr Yang, Tsung-Ying Ye, Yuanqing Yin, Zhihua and Yokota, Jun Yoon, Ho-Il Yu, Chong-Jen Yu, Herbert and Yu, Kai Yuan, Jian-Min Zelenetz, Andrew Zeleniuch-Jacquotte, Anne Zhang, Xu-Chao Zhang, Yawei Zhao, Xueying Zhao, Zhenhong Zheng, Hong Zheng, Tongzhang Zheng, Wei Zhou, Baosen Zhu, Meng Zucca, Mariagrazia Boca, Simina M. and Cerhan, James R. Ferri, Giovanni M. Hartge, Patricia Hsiung, Chao Agnes Magnani, Corrado Miligi, Lucia Morton, Lindsay M. and Smedby, Karin E. Teras, Lauren R. Vijai, Joseph Wang, Sophia S. Brennan, Paul Caporaso, Neil E. Hunter, David J. and Kraft, Peter Rothman, Nathaniel Silverman, Debra T. and Slager, Susan L. Chanock, Stephen J. Chatterjee, Nilanjan

Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

177. Caesarean delivery and risk of childhood leukaemia : a pooled analysis from the Childhood Leukemia International Consortium (CLIC)

Author

Marcotte, Erin L., Thomopoulos, Thomas P., Infante-Rivard, Claire, Clavel, Jacqueline, Petridou, Eleni Th, Schuz, Joachim, Ezzat, Sameera, Dockerty, John D., Metayer, Catherine, Magnani, Corrado, Scheurer, Michael E., Mueller, Beth A., Mora, Ana M., Wesseling, Catharina, Skalkidou, Alkistis, Rashed, Wafaa M., Francis, Stephen S., Ajrouche, Roula, Erdmann, Friederike, Orsi, Laurent, Spector, Logan G., Marcotte, Erin L., Thomopoulos, Thomas P., Infante-Rivard, Claire, Clavel, Jacqueline, Petridou, Eleni Th, Schuz, Joachim, Ezzat, Sameera, Dockerty, John D., Metayer, Catherine, Magnani, Corrado, Scheurer, Michael E., Mueller, Beth A., Mora, Ana M., Wesseling, Catharina, Skalkidou, Alkistis, Rashed, Wafaa M., Francis, Stephen S., Ajrouche, Roula, Erdmann, Friederike, Orsi, Laurent, and Spector, Logan G.

Abstract

Background Results from case-control studies have shown an increased risk of acute lymphoblastic leukaemia (ALL) in young children born by caesarean delivery, and prelabour caesarean delivery in particular; however, an association of method of delivery with childhood leukaemia subtypes has yet to be established. We therefore did a pooled analysis of data to investigate the association between childhood leukaemia and caesarean delivery. Methods We pooled data from 13 case-control studies from the Childhood Leukemia International Consortium done in nine countries (Canada, Costa Rica, Egypt, France, Germany, Greece, Italy, New Zealand, and the USA) for births from 1970-2013. We analysed caesarean delivery overall and by indications that probably resulted in prelabour caesarean delivery or emergency caesarean delivery. We used multivariable logistic regression models, adjusted for child's birthweight, sex, age, ethnic origin, parental education, maternal age, and study, to estimate odds ratios (ORs) and 95% CIs for the risk of ALL and acute myeloid leukaemia (AML) in children aged 0-14 years at diagnosis. Findings The studies provided data for 8780 ALL cases, 1332 AML cases, and 23 459 controls, of which the birth delivery method was known for 8655 (99%) ALL cases, 1292 (97%) AML cases, and 23 351 (> 99%) controls. Indications for caesarean delivery were available in four studies (there were caesarean deliveries for 1061 of 4313 ALL cases, 138 of 664 AML cases, and 1401 of 5884 controls). The OR for all indications of caesarean delivery and ALL was 1.06 (95% CI 0.99-1.13), and was significant for prelabour caesarean delivery and ALL (1.23 [1.04-1.47]; p= 0.018). Emergency caesarean delivery was not associated with ALL (OR 1.02 [95% CI 0.81-1.30]). AML was not associated with caesarean delivery (all indications OR 0.99 [95% CI 0.84-1.17]; prelabour caesarean delivery 0.83 [0.54-1.26]; and emergency caesarean delivery 1.05 [0.63-1.77]). Interpretation Our results sugge

Published
2016
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178. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)

Author

Sub ISEP overig, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Organisation Studies, dIRAS RA-2, Portier, Christopher J, Armstrong, Bruce K, Baguley, Bruce C, Baur, Xaver, Belyaev, Igor, Bellé, Robert, Belpoggi, Fiorella, Biggeri, Annibale, Bosland, Maarten C, Bruzzi, Paolo, Budnik, Lygia Therese, Bugge, Merete D, Burns, Kathleen, Calaf, Gloria M, Carpenter, David O, Carpenter, Hillary M, López-Carrillo, Lizbeth, Clapp, Richard, Cocco, Pierluigi, Consonni, Dario, Comba, Pietro, Craft, Elena, Dalvie, Mohamed Aqiel, Davis, Devra, Demers, Paul A, De Roos, Anneclaire J, DeWitt, Jamie, Forastiere, Francesco, Freedman, Jonathan H, Fritschi, Lin, Gaus, Caroline, Gohlke, Julia M, Goldberg, Marcel, Greiser, Eberhard, Hansen, Johnni, Hardell, Lennart, Hauptmann, Michael, Huang, Wei, Huff, James, James, Margaret O, Jameson, C W, Kortenkamp, Andreas, Kopp-Schneider, Annette, Kromhout, Hans, Larramendy, Marcelo L, Landrigan, Philip J, Lash, Lawrence H, Leszczynski, Dariusz, Lynch, Charles F, Magnani, Corrado, Mandrioli, Daniele, Martin, Francis L, Merler, Enzo, Michelozzi, Paola, Miligi, Lucia, Miller, Anthony B, Mirabelli, Dario, Mirer, Franklin E, Naidoo, Saloshni, Perry, Melissa J, Petronio, Maria Grazia, Pirastu, Roberta, Portier, Ralph J, Ramos, Kenneth S, Robertson, Larry W, Rodriguez, Theresa, Röösli, Martin, Ross, Matt K, Roy, Deodutta, Rusyn, Ivan, Saldiva, Paulo, Sass, Jennifer, Savolainen, Kai, Scheepers, Paul T J, Sergi, Consolato, Silbergeld, Ellen K, Smith, Martyn T, Stewart, Bernard W, Sutton, Patrice, Tateo, Fabio, Terracini, Benedetto, Thielmann, Heinz W, Thomas, David B, Vainio, Harri, Vena, John E, Vineis, Paolo, Weiderpass, Elisabete, Weisenburger, Dennis D, Woodruff, Tracey J, Yorifuji, Takashi, Yu, Il Je, Zambon, Paola, Zeeb, Hajo, Zhou, Shu-Feng, Sub ISEP overig, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Organisation Studies, dIRAS RA-2, Portier, Christopher J, Armstrong, Bruce K, Baguley, Bruce C, Baur, Xaver, Belyaev, Igor, Bellé, Robert, Belpoggi, Fiorella, Biggeri, Annibale, Bosland, Maarten C, Bruzzi, Paolo, Budnik, Lygia Therese, Bugge, Merete D, Burns, Kathleen, Calaf, Gloria M, Carpenter, David O, Carpenter, Hillary M, López-Carrillo, Lizbeth, Clapp, Richard, Cocco, Pierluigi, Consonni, Dario, Comba, Pietro, Craft, Elena, Dalvie, Mohamed Aqiel, Davis, Devra, Demers, Paul A, De Roos, Anneclaire J, DeWitt, Jamie, Forastiere, Francesco, Freedman, Jonathan H, Fritschi, Lin, Gaus, Caroline, Gohlke, Julia M, Goldberg, Marcel, Greiser, Eberhard, Hansen, Johnni, Hardell, Lennart, Hauptmann, Michael, Huang, Wei, Huff, James, James, Margaret O, Jameson, C W, Kortenkamp, Andreas, Kopp-Schneider, Annette, Kromhout, Hans, Larramendy, Marcelo L, Landrigan, Philip J, Lash, Lawrence H, Leszczynski, Dariusz, Lynch, Charles F, Magnani, Corrado, Mandrioli, Daniele, Martin, Francis L, Merler, Enzo, Michelozzi, Paola, Miligi, Lucia, Miller, Anthony B, Mirabelli, Dario, Mirer, Franklin E, Naidoo, Saloshni, Perry, Melissa J, Petronio, Maria Grazia, Pirastu, Roberta, Portier, Ralph J, Ramos, Kenneth S, Robertson, Larry W, Rodriguez, Theresa, Röösli, Martin, Ross, Matt K, Roy, Deodutta, Rusyn, Ivan, Saldiva, Paulo, Sass, Jennifer, Savolainen, Kai, Scheepers, Paul T J, Sergi, Consolato, Silbergeld, Ellen K, Smith, Martyn T, Stewart, Bernard W, Sutton, Patrice, Tateo, Fabio, Terracini, Benedetto, Thielmann, Heinz W, Thomas, David B, Vainio, Harri, Vena, John E, Vineis, Paolo, Weiderpass, Elisabete, Weisenburger, Dennis D, Woodruff, Tracey J, Yorifuji, Takashi, Yu, Il Je, Zambon, Paola, Zeeb, Hajo, and Zhou, Shu-Feng

Published
2016

179. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)

Author

Sub IER overig, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Organisation Studies, dIRAS RA-2, Portier, Christopher J, Armstrong, Bruce K, Baguley, Bruce C, Baur, Xaver, Belyaev, Igor, Bellé, Robert, Belpoggi, Fiorella, Biggeri, Annibale, Bosland, Maarten C, Bruzzi, Paolo, Budnik, Lygia Therese, Bugge, Merete D, Burns, Kathleen, Calaf, Gloria M, Carpenter, David O, Carpenter, Hillary M, López-Carrillo, Lizbeth, Clapp, Richard, Cocco, Pierluigi, Consonni, Dario, Comba, Pietro, Craft, Elena, Dalvie, Mohamed Aqiel, Davis, Devra, Demers, Paul A, De Roos, Anneclaire J, DeWitt, Jamie, Forastiere, Francesco, Freedman, Jonathan H, Fritschi, Lin, Gaus, Caroline, Gohlke, Julia M, Goldberg, Marcel, Greiser, Eberhard, Hansen, Johnni, Hardell, Lennart, Hauptmann, Michael, Huang, Wei, Huff, James, James, Margaret O, Jameson, C W, Kortenkamp, Andreas, Kopp-Schneider, Annette, Kromhout, Hans, Larramendy, Marcelo L, Landrigan, Philip J, Lash, Lawrence H, Leszczynski, Dariusz, Lynch, Charles F, Magnani, Corrado, Mandrioli, Daniele, Martin, Francis L, Merler, Enzo, Michelozzi, Paola, Miligi, Lucia, Miller, Anthony B, Mirabelli, Dario, Mirer, Franklin E, Naidoo, Saloshni, Perry, Melissa J, Petronio, Maria Grazia, Pirastu, Roberta, Portier, Ralph J, Ramos, Kenneth S, Robertson, Larry W, Rodriguez, Theresa, Röösli, Martin, Ross, Matt K, Roy, Deodutta, Rusyn, Ivan, Saldiva, Paulo, Sass, Jennifer, Savolainen, Kai, Scheepers, Paul T J, Sergi, Consolato, Silbergeld, Ellen K, Smith, Martyn T, Stewart, Bernard W, Sutton, Patrice, Tateo, Fabio, Terracini, Benedetto, Thielmann, Heinz W, Thomas, David B, Vainio, Harri, Vena, John E, Vineis, Paolo, Weiderpass, Elisabete, Weisenburger, Dennis D, Woodruff, Tracey J, Yorifuji, Takashi, Yu, Il Je, Zambon, Paola, Zeeb, Hajo, Zhou, Shu-Feng, Sub IER overig, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Organisation Studies, dIRAS RA-2, Portier, Christopher J, Armstrong, Bruce K, Baguley, Bruce C, Baur, Xaver, Belyaev, Igor, Bellé, Robert, Belpoggi, Fiorella, Biggeri, Annibale, Bosland, Maarten C, Bruzzi, Paolo, Budnik, Lygia Therese, Bugge, Merete D, Burns, Kathleen, Calaf, Gloria M, Carpenter, David O, Carpenter, Hillary M, López-Carrillo, Lizbeth, Clapp, Richard, Cocco, Pierluigi, Consonni, Dario, Comba, Pietro, Craft, Elena, Dalvie, Mohamed Aqiel, Davis, Devra, Demers, Paul A, De Roos, Anneclaire J, DeWitt, Jamie, Forastiere, Francesco, Freedman, Jonathan H, Fritschi, Lin, Gaus, Caroline, Gohlke, Julia M, Goldberg, Marcel, Greiser, Eberhard, Hansen, Johnni, Hardell, Lennart, Hauptmann, Michael, Huang, Wei, Huff, James, James, Margaret O, Jameson, C W, Kortenkamp, Andreas, Kopp-Schneider, Annette, Kromhout, Hans, Larramendy, Marcelo L, Landrigan, Philip J, Lash, Lawrence H, Leszczynski, Dariusz, Lynch, Charles F, Magnani, Corrado, Mandrioli, Daniele, Martin, Francis L, Merler, Enzo, Michelozzi, Paola, Miligi, Lucia, Miller, Anthony B, Mirabelli, Dario, Mirer, Franklin E, Naidoo, Saloshni, Perry, Melissa J, Petronio, Maria Grazia, Pirastu, Roberta, Portier, Ralph J, Ramos, Kenneth S, Robertson, Larry W, Rodriguez, Theresa, Röösli, Martin, Ross, Matt K, Roy, Deodutta, Rusyn, Ivan, Saldiva, Paulo, Sass, Jennifer, Savolainen, Kai, Scheepers, Paul T J, Sergi, Consolato, Silbergeld, Ellen K, Smith, Martyn T, Stewart, Bernard W, Sutton, Patrice, Tateo, Fabio, Terracini, Benedetto, Thielmann, Heinz W, Thomas, David B, Vainio, Harri, Vena, John E, Vineis, Paolo, Weiderpass, Elisabete, Weisenburger, Dennis D, Woodruff, Tracey J, Yorifuji, Takashi, Yu, Il Je, Zambon, Paola, Zeeb, Hajo, and Zhou, Shu-Feng

Published
2016

180. Authors' response: Mezei et al's "Comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis".

Author

Marinaccio, Alessandro, Consonni, Dario, Mensi, Carolina, Mirabelli, Dario, Migliore, Enrica, Magnani, Corrado, Di Marzio, Davide, Gennaro, Valerio, Mazzoleni, Guido, Girardi, Paolo, Negro, Corrado, Romanelli, Antonio, Chellini, Elisabetta, Grappasonni, Iolanda, Madeo, Gabriella, Romeo, Elisa, Ascoli, Valeria, Carrozza, Francesco, Angelillo, Italo Francesco, and Cavone, Domenica

Subjects
TOXICOLOGY of asbestos, MESOTHELIOMA, PERICARDIUM, CASE-control method, TESTIS, WORKERS' compensation
Published
2021
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181. Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the Childhood Leukemia International Consortium

Author

Bailey, Helen D, Fritschi, Lin, Infante-Rivard, Claire, Glass, Deborah C, Miligi, Lucia, Dockerty, John D, Lightfoot, Tracy, Clavel, Jacqueline, Roman, Eve, Spector, Logan G, Kaatsch, Peter, Metayer, Catherine, Magnani, Corrado, Milne, Elizabeth, Polychronopoulou, Sophia, Simpson, Jill, Rudant, Jérémie, Sidi, Vasiliki, Rondelli, Roberto, Orsi, Laurent, Kang, Alice, Petridou, Eleni, and Schüz, Joachim

Subjects
Male, Leukemia, Adolescent, Infant, Newborn, Infant, International Agencies, Prognosis, Article, Meta-Analysis as Topic, Maternal Exposure, Pregnancy, Risk Factors, Case-Control Studies, Child, Preschool, Occupational Exposure, Prenatal Exposure Delayed Effects, Paternal Exposure, Humans, Female, Pesticides, Child, Pregnancy Complications, Neoplastic, Follow-Up Studies
Abstract

Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 (95% confidence interval (CI) 0.78, 1.30) and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of five years or more and those with T cell ALL which raises interesting questions on possible mechanisms.

Published
2014

182. Survival and dementia in GBA‐associated Parkinson's disease: The mutation matters

Author

Cilia, Roberto, primary, Tunesi, Sara, additional, Marotta, Giorgio, additional, Cereda, Emanuele, additional, Siri, Chiara, additional, Tesei, Silvana, additional, Zecchinelli, Anna L., additional, Canesi, Margherita, additional, Mariani, Claudio B., additional, Meucci, Nicoletta, additional, Sacilotto, Giorgio, additional, Zini, Michela, additional, Barichella, Michela, additional, Magnani, Corrado, additional, Duga, Stefano, additional, Asselta, Rosanna, additional, Soldà, Giulia, additional, Seresini, Agostino, additional, Seia, Manuela, additional, Pezzoli, Gianni, additional, and Goldwurm, Stefano, additional

Published
2016
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183. O32-3 A pooled cohort study on cancer risk among former asbestos-exposed workers: role of asbestos clearance in explaining long-term mortality trend for pleural cancer

Author

Magnani, Corrado, primary, Barone-Adesi, Francesco, additional, Ferrante, Daniela, additional, Ancona, Laura, additional, Baldassarre, Antonio, additional, Bressan, Vittoria, additional, Cena, Tizian, additional, Chellini, Elisabetta, additional, Cuccaro, Francesco, additional, Legittimo, Patrizia, additional, Luberto, Ferdinando, additional, Marinaccio, Alessandro, additional, Mattioli, Stefano, additional, Menegozzo, Simona, additional, Merler, Enzo, additional, Miligi, Lucia, additional, Mirabelli, Dario, additional, Musti, Marina, additional, Oddone, Enrico, additional, Pavone, Venere, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Pirastu, Roberta, additional, Ranucci, Alessandra, additional, Romeo, Elisa, additional, Sala, Orietta, additional, Scarnato, Corrado, additional, Silvestri, Stefano, additional, and W, G, additional

Published
2016
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184. O08-3 Aryl hydrocarbon receptor (AHR) activation and risk of lymphoma subtypes

Author

Cocco, Pierluigi, primary, Ennas, Maria Grazia, additional, Zucca, Mariagrazia, additional, Sanna, Sonia, additional, Padoan, Marina, additional, Gambelunghe, Angela, additional, Scarpa, Aldo, additional, Ferri, Giovanni Maria, additional, Miligi, Lucia, additional, Lollo, Simonetta Di, additional, Muzi, Giacomo, additional, Magnani, Corrado, additional, and Campagna, Marcello, additional

Published
2016
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185. A pooled cohort analysis on cancer risk among former asbestos-exposed workers: role of asbestos clearance in explaining long-term mortality trend for pleural cancer.

Author

Magnani, Corrado, primary, Barone-Adesi*, Francesco, additional, Ferrante, Daniela, additional, Ancona, Laura, additional, Baldassarre, Antonio, additional, Bressan, Vittoria, additional, Cena, Tiziana, additional, Chellini, Elisabetta, additional, Cuccaro, Francesco, additional, Legittimo, Patrizia, additional, Luberto, Ferdinando, additional, Marinaccio, Alessandro, additional, Mattioli, Stefano, additional, Menegozzo, Simona, additional, Merler, Enzo, additional, Miligi, Lucia, additional, Mirabelli, Dario, additional, Musti, Marina, additional, Oddone, Enrico, additional, Pavone, Venere, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Pirastu, Roberta, additional, Ranucci, Alessandra, additional, Romeo, Elisa, additional, Sala, Orietta, additional, Scarnato, Corrado, additional, Silvestri, Stefano, additional, and Group, Working, additional

Published
2016
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190. Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC)

Author

Marcotte, Erin L, primary, Thomopoulos, Thomas P, additional, Infante-Rivard, Claire, additional, Clavel, Jacqueline, additional, Petridou, Eleni Th, additional, Schüz, Joachim, additional, Ezzat, Sameera, additional, Dockerty, John D, additional, Metayer, Catherine, additional, Magnani, Corrado, additional, Scheurer, Michael E, additional, Mueller, Beth A, additional, Mora, Ana M, additional, Wesseling, Catharina, additional, Skalkidou, Alkistis, additional, Rashed, Wafaa M, additional, Francis, Stephen S, additional, Ajrouche, Roula, additional, Erdmann, Friederike, additional, Orsi, Laurent, additional, and Spector, Logan G, additional

Published
2016
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191. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)

Author

Portier, Christopher J, primary, Armstrong, Bruce K, additional, Baguley, Bruce C, additional, Baur, Xaver, additional, Belyaev, Igor, additional, Bellé, Robert, additional, Belpoggi, Fiorella, additional, Biggeri, Annibale, additional, Bosland, Maarten C, additional, Bruzzi, Paolo, additional, Budnik, Lygia Therese, additional, Bugge, Merete D, additional, Burns, Kathleen, additional, Calaf, Gloria M, additional, Carpenter, David O, additional, Carpenter, Hillary M, additional, López-Carrillo, Lizbeth, additional, Clapp, Richard, additional, Cocco, Pierluigi, additional, Consonni, Dario, additional, Comba, Pietro, additional, Craft, Elena, additional, Dalvie, Mohamed Aqiel, additional, Davis, Devra, additional, Demers, Paul A, additional, De Roos, Anneclaire J, additional, DeWitt, Jamie, additional, Forastiere, Francesco, additional, Freedman, Jonathan H, additional, Fritschi, Lin, additional, Gaus, Caroline, additional, Gohlke, Julia M, additional, Goldberg, Marcel, additional, Greiser, Eberhard, additional, Hansen, Johnni, additional, Hardell, Lennart, additional, Hauptmann, Michael, additional, Huang, Wei, additional, Huff, James, additional, James, Margaret O, additional, Jameson, C W, additional, Kortenkamp, Andreas, additional, Kopp-Schneider, Annette, additional, Kromhout, Hans, additional, Larramendy, Marcelo L, additional, Landrigan, Philip J, additional, Lash, Lawrence H, additional, Leszczynski, Dariusz, additional, Lynch, Charles F, additional, Magnani, Corrado, additional, Mandrioli, Daniele, additional, Martin, Francis L, additional, Merler, Enzo, additional, Michelozzi, Paola, additional, Miligi, Lucia, additional, Miller, Anthony B, additional, Mirabelli, Dario, additional, Mirer, Franklin E, additional, Naidoo, Saloshni, additional, Perry, Melissa J, additional, Petronio, Maria Grazia, additional, Pirastu, Roberta, additional, Portier, Ralph J, additional, Ramos, Kenneth S, additional, Robertson, Larry W, additional, Rodriguez, Theresa, additional, Röösli, Martin, additional, Ross, Matt K, additional, Roy, Deodutta, additional, Rusyn, Ivan, additional, Saldiva, Paulo, additional, Sass, Jennifer, additional, Savolainen, Kai, additional, Scheepers, Paul T J, additional, Sergi, Consolato, additional, Silbergeld, Ellen K, additional, Smith, Martyn T, additional, Stewart, Bernard W, additional, Sutton, Patrice, additional, Tateo, Fabio, additional, Terracini, Benedetto, additional, Thielmann, Heinz W, additional, Thomas, David B, additional, Vainio, Harri, additional, Vena, John E, additional, Vineis, Paolo, additional, Weiderpass, Elisabete, additional, Weisenburger, Dennis D, additional, Woodruff, Tracey J, additional, Yorifuji, Takashi, additional, Yu, Il Je, additional, Zambon, Paola, additional, Zeeb, Hajo, additional, and Zhou, Shu-Feng, additional

Published
2016
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192. New versus Conventional Helmet for Delivering Noninvasive Ventilation

Author

Olivieri, Carlo, primary, Longhini, Federico, additional, Cena, Tiziana, additional, Cammarota, Gianmaria, additional, Vaschetto, Rosanna, additional, Messina, Antonio, additional, Berni, Paola, additional, Magnani, Corrado, additional, Della Corte, Francesco, additional, and Navalesi, Paolo, additional

Published
2016
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193. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., De Vivo, Immaculata, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, Maria-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Franoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr., Freedman, Neal D., Freeman, Laura E. Beane, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, Garcia-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Göran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Di Lollo, Simonetta, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Le Marchand, Loic, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, Mckay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patino-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., de Sanjose, Silvia, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesumaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardon, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjonneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., Chatterjee, Nilanjan, Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., De Vivo, Immaculata, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, Maria-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Franoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr., Freedman, Neal D., Freeman, Laura E. Beane, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, Garcia-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Göran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Di Lollo, Simonetta, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Le Marchand, Loic, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, Mckay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patino-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., de Sanjose, Silvia, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesumaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardon, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjonneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan

Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusio

Published
2015
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194. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, Chatterjee, Nilanjan, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, and Chatterjee, Nilanjan

Published
2015

195. Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: A childhood leukemia international consortium study

Author

Rudant, Jeremie, Lightfoot, Tracy, Urayama, Kevin Y., Petridou, Eleni, Dockerty, John D., Magnani, Corrado, Milne, Elizabeth, Spector, Logan G., Ashton, Lesley J., Dessypris, Nikolaos, Kang, Alice Y., Miller, Margaret, Rondelli, Roberto, Simpson, Jill, Stiakaki, Eftichia, Orsi, Laurent, Roman, Eve, Metayer, Catherine, Infante-Rivard, Claire, Clavel, Jaqueline, Rudant, Jeremie, Lightfoot, Tracy, Urayama, Kevin Y., Petridou, Eleni, Dockerty, John D., Magnani, Corrado, Milne, Elizabeth, Spector, Logan G., Ashton, Lesley J., Dessypris, Nikolaos, Kang, Alice Y., Miller, Margaret, Rondelli, Roberto, Simpson, Jill, Stiakaki, Eftichia, Orsi, Laurent, Roman, Eve, Metayer, Catherine, Infante-Rivard, Claire, and Clavel, Jaqueline

Abstract

The associations between childhood acute lymphoblastic leukemia (ALL) and several proxies of early stimulation of the immune system, that is, day-care center attendance, birth order, maternally reported common infections in infancy, and breastfeeding, were investigated by using data from 11 case-control studies participating in the Childhood Leukemia International Consortium (enrollment period: 1980-2010). The sample included 7,399 ALL cases and 11,181 controls aged 2-14 years. The data were collected by questionnaires administered to the parents. Pooled odds ratios and 95% confidence intervals were estimated by unconditional logistic regression adjusted for age, sex, study, maternal education, and maternal age. Day-care center attendance in the first year of life was associated with a reduced risk of ALL (odds ratio = 0.77, 95% confidence interval: 0.71, 0.84), with a marked inverse trend with earlier age at start (P < 0.0001). An inverse association was also observed with breastfeeding duration of 6 months or more (odds ratio = 0.86, 95% confidence interval: 0.79, 0.94). No significant relationship with a history of common infections in infancy was observed even though the odds ratio was less than 1 for more than 3 infections. The findings of this large pooled analysis reinforce the hypothesis that day-care center attendance in infancy and prolonged breastfeeding are associated with a decreased risk of ALL.

Published
2015

196. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, Chatterjee, Nilanjan, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, and Chatterjee, Nilanjan

Published
2015

197. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, Chatterjee, Nilanjan, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, and Chatterjee, Nilanjan

Published
2015

198. Incidence of soft tissue sarcomas in an area affected by illegal waste dumping sites

Author

Comba Pietro, Fazzo Lucia, Magnani Corrado, Fusco Mario, Buzzoni Carlotta, and Benedetti Marta

Subjects
Oncology, medicine.medical_specialty, Heterogeneous group, business.industry, Incidence (epidemiology), Cancer, Soft tissue, medicine.disease, Increased risk, Internal medicine, medicine, General Earth and Planetary Sciences, business, General Environmental Science
Abstract

Background and Aim: Soft tissue sarcomas (STSs) are a heterogeneous group of rare malignant neoplasms. Increased risk of STSs was observed in some studies of persons living in the proximity of inci...

Published
2013

200. On the diagnosis of malignant pleural mesothelioma: A necropsy-based study of 171 cases (1997–2016)

Author

Barbieri, Pietro Gino, Mirabelli, Dario, Magnani, Corrado, and Brollo, Alessandro

Abstract

Background: Malignant pleural mesothelioma (MPM) diagnosis is known to be difficult. We report on the diagnostic elements available in life in an MPM necropsy case series and describe the frequency of non-neoplastic asbestos-related diseases as biological exposure indices.Methods: We reviewed pathologic and clinical records of an unselected series of autopsies (1977–2016) in patients with MPM employed in the Monfalcone shipyards or living with shipyard workers. We assessed the consistency with autopsy results of diagnoses based on, respectively, radiologic, cytologic, and histologic findings, with and without immunophenotyping.Results: Data on 171 cases were available: for 169, autopsy confirmed the MPM diagnosis. In life, 119 cases had histologic confirmation of diagnosis, whereas 7 were negative; all cases without immunophenotypization were autoptic MPMs. Cytology alone had been positive in 18 autoptic MPM cases, negative in 14. Radiologic imaging alone had been positive in another 16, negative in 11. In the 2 cases not confirmed at autopsy, MPM had been suspected by chest computed tomography only. Bilateral pleural plaques were found in 144 and histologic evidence of asbestosis in 62 cases.Conclusions: Autopsies confirmed 169/171 cases, including cases that would not be considered as certain based on diagnosis in life. Radiologic imaging, cytologic examination of pleural effusions, or both combined had low sensitivity but high positive predictive value: when they are positive, proceeding to thoracoscopy should be justified. MPM has been correctly diagnosed even without immunohistochemistry. The prevalence of pleural plaques and asbestosis was high due to severity of asbestos exposures in these cases.

Published
2019
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