Search

Dressings are necessary during the process of wound healing. Since the early 1980s, several types of wound dressings have been produced, but they cannot always take into account some effects include antibacterial effect, wound healing promotion, and other properties. In this study, we would like to develop an effective dressing with the above properties, especially accelerating wound healing effect. A chitosan‐calcium alginate dressing (CCAD) was developed by coating mixture of chitosan with high‐low molecular weight on calcium alginate dressing (CAD). We investigated the structural characteristics of CCAD with Fourier‐transform infrared spectroscopy (FTIR) and electron microscopy. The cytotoxicity and antibacterial property were evaluated in vitro using CCK‐8 and inhibition zone method. Moisture retention was tested on the skin of Sprague‐Dawley (SD) rats, and wound healing studies were performed on a full‐thickness skin wound model in SD rats. CCAD showed good moisturizing and antibacterial properties with no cytotoxicity. CCAD could inhibit inflammation by decreasing IL‐6, and it could also promote angiogenesis by increasing VEGF, resulting in better wound healing than CAD. CCAD is a better choice in wound care due to its antibacterial property, biocompatibility, moisture retention, healing promotion, and non‐cytotoxicity characteristics. [ABSTRACT FROM AUTHOR]

An acidic solution based method towards flexible lithium ion battery (LIB) cathodes is developed in this work with perylene diimide (PDI) as the electroactive component and carbon cloth (CC) as the current collector. In this approach, PDI is firstly dispersed in concentrated sulfuric acid (H2SO4) and then deposited on CC substrate after the dilution of H2S04, which provides an organic solvent-free strategy to construct integrated LIB cathodes. The acdic solution based fabrication process also allows the facile adjusting of loading amounts of PDI in the cathodes, which can effectively influence the battery performances of the PDI/CC cathodes. As the result, the acidic solution processed PDI/CC cathode can deliver a high specific capacity of ~ 36mAh.g-1 at the current density of 50 m A.g-1 in both half cell with lithium foil as anode and full cell with pre-lithiated CC as anode. In both types of the batteries, the PDI/CC cathodes show good cycling stabilities by retaining ~ 84% of the initial capacities after 300 charge-discharge cycles at 500 mA.g-1. Additionally, the excellent mechanical stability of the PDI/CC cathode enables the LIBs in pouch cell to maintain the electrochemical performances under various bending states, demonstrating their potentials for flexible LIBs. [ABSTRACT FROM AUTHOR]

• This study used transcriptome sequencing technology to successfully obtain transcriptome data of Vibro splendidus , Aeromonas hydrophila and Saprolegnia parasitica infected lamprey larvae. • In this study, we found differentially expressed genes caused by lamprey larvae infected with three pathogens, and the signaling pathways were queried by GO and KEGG enrichment. • This study provides useful information for further understanding mechanisms of antibacterial immunity in lamprey larvae and the artificial propagation of lamprey. Based on the large number of deaths of lamprey larvae infected by pathogens in the culture process, the infection response of lamprey larvae to different pathogens was studied. Thus, high-throughput sequencing is firstly used to analyze the lamprey larvae infected by Aeromonas hydrophila , Vibrosplendidus , and Saprolegnia parasitica. A high quality of 338,628,426 Reads were obtained and 203,829 transcripts were assembled. A total of 158,001 Unigenes were annotated by Blast comparison, and a relatively comprehensive transcriptome database of lamprey larvae was established. Based on the transcriptome of lamprey larvae infected by three aquatic pathogens, classification results of COG and GO show that the genes classified into signal transduction mechanism accounted for the largest proportion, and 2316 differentially expressed genes were identified and screened out. After infection by the three pathogens, 16 genes and 19 genes expression were up-regulated and down-regulated, respectively. KEGG pathway analysis of differentially expressed genes showed that lamprey larvae were mainly affected their metabolism and oxidative phosphorylation pathways after infection by two gram-negative bacteria, Vibrosplendidus and Aeromonas hydrophila. As a fungus, Saprolegnia parasitica mainly affected ribosome synthesis in lamprey larvae. The results were validated by detecting the expression levels of 13 DEGs at 24 h after pathogens treatment using Q-PCR. The results provide valuable information for further research into the development of immunity and the innate immune response against pathogen invasion during the artificial propagation of lamprey larvae. [ABSTRACT FROM AUTHOR]

Triple negative breast cancer (TNBC), characterized by the absence of the estrogen (ER), progesterone (PR) receptors, and the human epidermal growth factor receptor 2 (HER2/HER neu), accounts for about 20% of all breast cancer cases [[1]]. A-D. Fraction C was subjected to silica gel CC eluting with petroleum ether-acetone (20:1) followed by purification on an ODS C18 column eluting with MeOH-H SB 2 sb O (80:20) to furnish B 1 b (28.8 mg) and B 8 b (200.7 mg). Subfraction D3 was separated successively by CC on a silica gel column eluting with petroleum ether-acetone (85:15) and Toyopearl HW 40C column eluting with MeOH to afford B 4 b (14.4 mg) and B 3 b (5.0 mg). To the best of our knowledge, compound B 4 b was isolated from Ascomycetes, while compounds B 2 b and 3 were obtained from the fungal genus I Neosartorya i for the first time. [Extracted from the article]

Flexible organic cathodes with 3,4,9,10-perylenetetracarboxylic diimide (PDI) as the active component, carbon black (CB) as the conductive agent and thermoplastic polyurethane (TPU) as the elastomeric matrix are obtained in this work via a solution-based phase inversion approach. In the resulting PDI/CB/TPU cathodes, the mass ratios of the three components manifest profound influences on their composition, flexibility, conductivity and lithium storage behavior. The integrated PDI/CB/TPU cathode with optimized ratio can deliver impressive rate capability and good cycling stability in lithium ion batteries (LIBs). More importantly, the full LIBs with PDI/CB/TPU cathode and carbon cloth anode exhibit excellent electrochemical performances, which show no decay even at bending states, demonstrating the appealing prospects of the solution-processed organic cathodes in wearable secondary batteries. Obtained from a solution-based phase inversion approach, the flexible PDI/CB/TPU cathodes manifest excellent electrochemical performances and good mechanical stability in lithium ion batteries. Image 1 [ABSTRACT FROM AUTHOR]

Noncoding RNAs have recently emerged as versatile regulators of endothelial dysfunction in atherosclerosis, a chronic inflammatory disease characterized by the formation of plaques within the arterial walls. Through their ability to modulate gene expression, noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, play crucial roles in various cellular processes involved in endothelial dysfunction (ECD), such as inflammation, pyroptosis, migration, proliferation, apoptosis, oxidative stress, and angiogenesis. This review provides an overview of the current understanding of the regulatory roles of noncoding RNAs in endothelial dysfunction during atherosclerosis. It highlights the specific noncoding RNAs that have been implicated in the pathogenesis of ECD, their target genes, and the mechanisms by which they contribute to ECD. Furthermore, we have reviewed the current therapeutics in atherosclerosis and explore their interaction with noncoding RNAs. Understanding the intricate regulatory network of noncoding RNAs in ECD may open up new opportunities for the development of novel therapeutic strategies to combat ECD. [Display omitted] • Endothelial cell dysfunction (ECD) may be an important cause of atherosclerosis. • Noncoding RNAs (ncRNAs) have a major role in regulation of ECD. • Future studies are needed to confirm the importance of ncRNAs as a possible therapeutic strategy in atherosclerosis. [ABSTRACT FROM AUTHOR]