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This study aimed to better understand and quantify the influence of ventilation strategies on occupant-related indoor air chemistry. The oxidation of human skin oil constituents was studied in a continuously-ventilated climate chamber at two air exchange rates (1 h-1 and 3 h-1 ) and two initial ozone mixing ratios (30 ppb and 60 ppb). Additional measurements were performed to investigate the effect of intermittent ventilation ("off" followed by "on"). Soiled t-shirts were used to simulate the presence of occupants. A Time-of-Flight-Chemical Ionization-Mass-Spectrometer (ToF-CIMS) in positive mode using protonated water clusters was used to measure the oxygenated reaction products geranyl acetone, 6-methyl-5-hepten-2-one (6-MHO) and 4-oxopentanal (4-OPA). The measurement data were used in a series of mass balance models accounting for formation and removal processes. Reactions of ozone with squalene occurring on the surface of the t-shirts are mass transport limited; ventilation rate has only a small effect on this surface chemistry. Ozone-squalene reactions on the shirts produced gas-phase geranyl acetone, which was subsequently removed almost equally by ventilation and further reaction with ozone. About 70% of gas-phase 6-MHO was produced in surface reactions on the t-shirts, the remainder in secondary gas-phase reactions of ozone with geranyl acetone. 6-MHO was primarily removed by ventilation, while further reaction with ozone was responsible for about a third of its removal. 4-OPA was formed primarily on the surfaces of the shirts (~60%); gas-phase reactions of ozone with geranyl acetone and 6-MHO accounted for ~30% and ~10%, respectively. 4-OPA was removed entirely by ventilation. The results from the intermittent ventilation scenarios showed delayed formation of the reaction products and lower product concentrations compared to continuous ventilation. This article is protected by copyright.

Benzophenone-3 (also known as BP-3 or oxybenzone) is added to sunscreens, plastics, and some coatings to filter UV radiation. The suspected endocrine disruptor BP-3 has been detected in the air and settled dust of homes and is expected to redistribute from its original sources to other indoor compartments, including clothing. Given its physical and chemical properties, we hypothesized that dermal uptake from clothing could contribute to the body burden of this compound. First, cotton shirts were exposed to air at an elevated concentration of BP-3 for 32 days; the final air concentration was 4.4 μg/m3. Next, three participants wore the exposed shirts for 3 h. After 3 h of exposure, participants wore their usual clothing during the collection of urine samples for the next 48 h. Urine was analyzed for BP-3, a metabolite (BP-1), and six other UV filters. The rate of urinary excretion of the sum of BP-1 and BP-3 increased for all participants during and following the 3 h of exposure. The summed mass of BP-1 and BP-3 excreted during the first 24 h attributable to wearing exposed t-shirts were 12, 9.9, and 82μg for participants 1, 2, and 3, respectively. Analysis of these results, coupled with predictions of steady-state models, suggest that dermal uptake of BP-3 from clothing could meaningfully contribute to overall body burden.

We investigate the relationship between the black hole accretion rate (BHAR) and star-formation rate (SFR) for Milky Way (MW) and Andromeda (M31)-mass progenitors from z = 0.2 - 2.5. We source galaxies from the Ks-band selected ZFOURGE survey, which includes multi-wavelenth data spanning 0.3 - 160um. We use decomposition software to split the observed SEDs of our galaxies into their active galactic nuclei (AGN) and star-forming components, which allows us to estimate BHARs and SFRs from the infrared (IR). We perform tests to check the robustness of these estimates, including a comparison to BHARs and SFRs derived from X-ray stacking and far-IR analysis, respectively. We find as the progenit- ors evolve, their relative black hole-galaxy growth (i.e. their BHAR/SFR ratio) increases from low to high redshift. The MW-mass progenitors exhibit a log-log slope of 0.64 +/- 0.11, while the M31-mass progenitors are 0.39 +/- 0.08. This result contrasts with previous studies that find an almost flat slope when adopting X-ray/AGN-selected or mass-limited samples and is likely due to their use of a broad mixture of galaxies with different evolutionary histories. Our use of progenitor-matched samples highlights the potential importance of carefully selecting progenitors when searching for evolutionary relationships between BHAR/SFRs. Additionally, our finding that BHAR/SFR ratios do not track the rate at which progenitors quench casts doubts over the idea that the suppression of star-formation is predominantly driven by luminous AGN feedback (i.e. high BHARs)., Comment: 7 pages, 5 figures, Accepted for publication in MNRAS

Benzophenone-3 (aka BP-3, oxybenzone) is added to sunscreens, plastics and some coatings to filter UV radiation. A suspected endocrine disruptor, BP-3 has been widely detected and ot only in summertime, where a more intended use of sunscreen might be expected in the urine of Danish children (Frederiksen et al., 2016; Krause et al, 2016) and other populations. BP-3 has been found in the air and settled dust of homes (Wan et al., 2015) and is expected to redistribute from its original sources to other indoor compartments, including clothing. As has been previously observed for phthalates (Morrison et al., 2016), we hypothesized that dermal uptake from clothing would occur and could contribute to the body burden of this compound.

Six males clad only in shorts were exposed to high levels of airborne di(n-butyl) phthalate (DnBP) and diethyl phthalate (DEP) in chamber experiments conducted in 2014. In two 6 h sessions, the subjects were exposed only dermally while breathing clean air from a hood, and both dermally and via inhalation when exposed without a hood. Full urine samples were taken before, during, and for 48 h after leaving the chamber and measured for key DnBP and DEP metabolites. The data clearly demonstrated high levels of DnBP and DEP metabolite excretions while in the chamber and during the first 24 h once leaving the chamber under both conditions. The data for DnBP were used in a modeling exercise linking dose models for inhalation and transdermal permeation with a simple pharmacokinetic model that predicted timing and mass of metabolite excretions. These models were developed and calibrated independent of these experiments. Tests included modeling of the "hood-on" (transdermal penetration only), "hood-off" (both inhalation and transdermal) scenarios, and a derived "inhalation-only" scenario. Results showed that the linked model tended to duplicate the pattern of excretion with regard to timing of peaks, decline of concentrations over time, and the ratio of DnBP metabolites. However, the transdermal model tended to overpredict penetration of DnBP such that predictions of metabolite excretions were between 1.1 and 4.5 times higher than the cumulative excretion of DnBP metabolites over the 54 h of the simulation. A similar overprediction was not seen for the "inhalation-only" simulations. Possible explanations and model refinements for these overpredictions are discussed. In a demonstration of the linked model designed to characterize general population exposures to typical airborne indoor concentrations of DnBP in the United States, it was estimated that up to one-quarter of total exposures could be due to inhalation and dermal uptake.