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2,684 results on '"Lu, Da"'

151. Seasonal source identification and formation processes of marine particulate water soluble organic nitrogen over an offshore island in the East China Sea

Author

Tian, Mengke, primary, Li, Hao, additional, Wang, Guochen, additional, Fu, Mengxin, additional, Qin, Xiaofei, additional, Lu, Da, additional, Liu, Chengfeng, additional, Zhu, Yucheng, additional, Luo, Xingzhang, additional, Deng, Congrui, additional, Abdullaev, Sabur F., additional, and Huang, Kan, additional

Published
2023
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160. Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A

Author

Zhao, Tong, Zhou, Zhi-ruo, Wan, Hui-qi, Feng, Tian, Hu, Xu-hui, Li, Xiao-qian, Zhao, Shi-mei, Li, Hong-lin, Hou, Ji-wei, Li, Wei, Lu, Da-yun, Qian, Min-yi, and Shen, Xu

Abstract

Pulmonary fibrosis (PF) is a chronic, progressive and irreversible interstitial lung disease characterized by unremitting pulmonary myofibroblasts activation, extracellular matrix (ECM) deposition and inflammatory recruitment. PF has no curable medication yet. In this study we investigated the molecular pathogenesis and potential therapeutic targets of PF and discovered drug lead compounds for PF therapy. A murine PF model was established in mice by intratracheal instillation of bleomycin (BLM, 5 mg/kg). We showed that the protein level of pulmonary protein phosphatase magnesium-dependent 1A (PPM1A, also known as PP2Cα) was significantly downregulated in PF patients and BLM-induced PF mice. We demonstrated that TRIM47 promoted ubiquitination and decreased PPM1A protein in PF progression. By screening the lab in-house compound library, we discovered otilonium bromide (OB, clinically used for treating irritable bowel syndrome) as a PPM1A enzymatic activator with an EC50value of 4.23 μM. Treatment with OB (2.5, 5 mg·kg−1·d−1, i.p., for 20 days) significantly ameliorated PF-like pathology in mice. We constructed PF mice with PPM1A-specific knockdown in the lung tissues, and determined that by targeting PPM1A, OB treatment suppressed ECM deposition through TGF-β/SMAD3 pathway in fibroblasts, repressed inflammatory responses through NF-κB/NLRP3 pathway in alveolar epithelial cells, and blunted the crosstalk between inflammation in alveolar epithelial cells and ECM deposition in fibroblasts. Together, our results demonstrate that pulmonary PPM1A activation is a promising therapeutic strategy for PF and highlighted the potential of OB in the treatment of the disease.

Published
2024
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163. A Critical Appraisal of Different Food Safety and Quality Management Tools to Accomplish Food Safety

Author

Korada, Siva K., primary, Yarla, Nagendra S., additional, Putta, Swathi, additional, Hanumakonda, Avinash S., additional, Lakkappa, Dhananjaya B., additional, Bishayee, Anupam, additional, Scotti, Luciana, additional, Scotti, Marcus T., additional, Aliev, Gjumrakch, additional, Kamal, Mohammad A., additional, Lu, Da-Yong, additional, Aycan, Mukerrem B.Y., additional, Reggi, Raffaella, additional, Palmery, Maura, additional, Ashraf, Ghulam, additional, Alexiou, Thonas, additional, and Peluso, Ilaria, additional

Published
2018
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165. Secondary aerosol formation during a special dust transport event: impacts from unusually enhanced ozone and dust backflows over the ocean.

Author

Lu, Da, Li, Hao, Tian, Mengke, Wang, Guochen, Qin, Xiaofei, Zhao, Na, Huo, Juntao, Yang, Fan, Lin, Yanfen, Chen, Jia, Fu, Qingyan, Duan, Yusen, Dong, Xinyi, Deng, Congrui, Abdullaev, Sabur F., and Huang, Kan

Subjects
MINERAL dusts, DUST, OZONE, AEROSOLS, ALKALI metal ions, PARTICULATE matter, WIND speed
Abstract

In the autumn of 2019, a 5 d long-lasting dust event was observed using a synergy of field measurement techniques in Shanghai. This particular dust event stood out from others due to its unique characteristics, including low wind speed, high relative humidity, elevated levels of gaseous precursors, and contrasting wind patterns at different altitudes. During this event, three distinct dust stages were identified. The first stage was a typical dust invasion characterized by high concentrations of particulate matters but relatively short duration. In contrast, the second stage exhibited an unusual enhancement of ozone, attributed to compound causes of a weak synoptic system, transport from the ocean, and subsidence of high-altitude ozone downdrafted by dust. Consequently, gas-phase oxidation served as the major formation pathway of sulfate and nitrate. In the third stage of dust, a noteworthy phenomenon known as dust backflow occurred. The dust plume originated from the Shandong Peninsula and slowly drifted over the Yellow Sea and the East China Sea before eventually returning to Shanghai. Evidence of this backflow was found through the enrichment of marine vessel emissions (V and Ni) and increased solubility of calcium. Under the influence of humid oceanic breezes, the formation of nitrate was dominated by aqueous processing. Additionally, parts of nitrate and sulfate were directly transported via sea salts, evidenced by their co-variation with Na + and confirmed through thermodynamic modeling. The uptake of NH 3 on particles, influenced by the contributions of alkali metal ions and aerosol pH, regulated the formation potential of secondary aerosol. By developing an upstream–receptor relationship method, the quantities of transported and secondarily formed aerosol species were separated. This study highlights that the transport pathway of dust, coupled with environmental conditions, can significantly modify the aerosol properties, especially at the complex land–sea interface. [ABSTRACT FROM AUTHOR]

Published
2023
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195. [Effect of electroacupuncture at back

Author

Zhong-Xian, Li, Yu, Zhang, Lu-da, Yan, Mei-Qi, Lai, Hai-Yan, Xu, Ting, Wu, Rui-Ming, Chen, Guo-Ao, Shi, and Peng, Zhou

Subjects
Electroacupuncture, Fatigue Syndrome, Chronic, Cortical Excitability, Quality of Life, Humans, Acupuncture Points
Abstract

To observe the effect of electroacupuncture (EA) at back-A total of 72 patients with CFS were randomized into an EA group (36 cases, 4 cases dropped off) and a sham EA group (36 cases, 3 cases dropped off). In the EA group, EA at Ganshu (BL 18), Xinshu (BL 15), Pishu (BL 20), Feishu (BL 13) and Shenshu (BL 23) was adopted, with continuous wave, 2 Hz in frequency. In the sham EA group, sham EA at non-acupoints (1.5-2.0 cm lateral to back-After treatment, the physical fatigue score, mental fatigue score and total score of FS-14, as well as RMT of motor cortex in the EA group were decreased compared with those before treatment (EA at back

Published
2022

196. Ocean Emission Pathway and Secondary Formation Mechanism of Aminiums Over the Chinese Marginal Sea

Author

Liu, Chengfeng, primary, Li, Hao, additional, Zheng, Haitao, additional, Wang, Guochen, additional, Qin, Xiaofei, additional, Chen, Jia, additional, Zhou, Shengqian, additional, Lu, Da, additional, Liang, Guoping, additional, Song, Xiaoquan, additional, Duan, Yusen, additional, Liu, Jianguo, additional, Huang, Kan, additional, and Deng, Congrui, additional

Published
2022
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200. Integrative genomic and transcriptomic profiling reveals distinct molecular subsets in adult mixed phenotype acute leukemia

Author

Wang, Qian, primary, Cai, Wen‐zhi, additional, Wang, Qin‐rong, additional, Zhu, Ming‐qing, additional, Yan, Ling‐zhi, additional, Yu, Yan, additional, Bao, Xie‐bing, additional, Shen, Hong‐jie, additional, Yao, Hong, additional, Xie, Jun‐dan, additional, Zhang, Tong‐tong, additional, Zhang, Ling, additional, Xu, Xiao‐yu, additional, Shan, Zhe, additional, Liu, Hong, additional, Cen, Jian‐nong, additional, Liu, Dan‐dan, additional, Pan, Jin‐lan, additional, Lu, Da‐ru, additional, Chen, Jia, additional, Xu, Yang, additional, Zhang, Ri, additional, Wang, Ying, additional, Xue, Sheng‐li, additional, Miao, Miao, additional, Han, Yue, additional, Tang, Xiao‐wen, additional, Qiu, Hui‐ying, additional, Sun, Ai‐ning, additional, Huang, Jin‐yan, additional, Dai, Hai‐ping, additional, Wu, De‐pei, additional, and Chen, Su‐ning, additional

Published
2022
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