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1,425 results on '"Logothetis, Nikos K"'

192. NEUROSCIENCE: Rewiring the adult brain

Author

Smirnakis, Stelios M., Schmid, Michael C., Brewe, Alyssa A., Tolias, Andreas S., Schüz, Almut, Augath, Mark, Inhoffen, Werner, Wandell, Brian A., and Logothetis, Nikos K.

Published
2005

193. What is rivalling during binocular rivalry?

Author

Logothetis, Nikos K., Leopold, David A., and Sheinberg, David L.

Subjects
Binocular vision -- Research, Visual perception -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The competition for perceptual dominance during binocular rivalry occurs between the two stimuli in the eyes rather than between the eyes themselves. The perceptual changes caused by quickly alternating rival stimuli between the two eyes is similar to the temporal dynamic of stationary objects. There is a single phase of dominance for multiple changes in the stimuli. Thus, binocular rivalry is a general multistable phenomena.

Published
1996

194. Activity changes in early visual cortex reflect monkeys' percepts during binocular rivalry

Author

Leopold, David A. and Logothetis, Nikos K.

Subjects
Visual cortex -- Physiological aspects, Monkeys -- Research, Binocular vision -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Interaction between binocular neurons during various visual pathways produces binocular rivalry in monkeys. A quantitative analysis of various responses reveal that a distinct level of cells exhibits distinct responses to rivalrous and congruent stimuli. Analysis of perception-associated modulation in visual cortical areas V1, V2 and V4 of monkeys indicates that the V4 visual cortex area exhibits patterns of suppression and dominance of one stimulus.

Published
1996

197. Awakening: Predicting external stimulation to force transitions between different brain states

Author

Horn, Andreas, Massimini, Marcello, Deco, Gustavo, Cruzat, Josephine, Cabral, Joana, Tagliazucchi, Enzo, Laufs, Helmut, Logothetis, Nikos K., Kringelbach, Morten L., Horn, Andreas, Massimini, Marcello, Deco, Gustavo, Cruzat, Josephine, Cabral, Joana, Tagliazucchi, Enzo, Laufs, Helmut, Logothetis, Nikos K., and Kringelbach, Morten L.

Abstract

A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires a quantitative and robust definition of a brain state, which has so far proven elusive. Here, we provide such a definition, which, together with whole-brain modeling, permits the systematic study in silico of how simulated brain stimulation can force transitions between different brain states in humans. Specifically, we use a unique neuroimaging dataset of human sleep to systematically investigate where to stimulate the brain to force an awakening of the human sleeping brain and vice versa. We show where this is possible using a definition of a brain state as an ensemble of "metastable substates," each with a probabilistic stability and occurrence frequency fitted by a generative whole-brain model, fine-tuned on the basis of the effective connectivity. Given the biophysical limitations of direct electrical stimulation (DES) of microcircuits, this opens exciting possibilities for discovering stimulation targets and selecting connectivity patterns that can ensure propagation of DES-induced neural excitation, potentially making it possible to create awakenings from complex cases of brain injury.

Published
2019

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