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2,165 results on '"Llombart-Bosch, A."'

153. TuBaFrost 6: Virtual microscopy in virtual tumour banking

Author

Teodorovic, I., Isabelle, M., Carbone, A., Passioukov, A., Lejeune, S., Jaminé, D., Therasse, P., Gloghini, A., Dinjens, W.N.M., Lam, K.H., Oomen, M.H.A., Spatz, A., Ratcliffe, C., Knox, K., Mager, R., Kerr, D., Pezzella, F., van Damme, B., van de Vijver, M., van Boven, H., Morente, M.M., Alonso, S., Kerjaschki, D., Pammer, J., Lopez-Guerrero, J.A., Llombart Bosch, A., van Veen, E.-B., Oosterhuis, J.W., and Riegman, P.H.J.

Published
2006
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154. TuBaFrost 5: Multifunctional central database application for a European tumor bank

Author

Isabelle, M., Teodorovic, I., Morente, M.M., Jaminé, D., Passioukov, A., Lejeune, S., Therasse, P., Dinjens, W.N.M., Oosterhuis, J.W., Lam, K.H., Oomen, M.H.A., Spatz, A., Ratcliffe, C., Knox, K., Mager, R., Kerr, D., Pezzella, F., van de Vijver, M., van Boven, H., Alonso, S., Kerjaschki, D., Pammer, J., Lopez-Guerrero, J.A., Llombart Bosch, A., Carbone, A., Gloghini, A., van Veen, E.-B., van Damme, B., and Riegman, P.H.J.

Published
2006
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155. TuBaFrost 4: Access rules and incentives for a European tumour bank

Author

Lopez-Guerrero, J.A., Riegman, P.H.J., Oosterhuis, J.W., Lam, K.H., Oomen, M.H.A., Spatz, A., Ratcliffe, C., Knox, K., Mager, R., Kerr, D., Pezzella, F., van Damme, B., van de Vijver, M., van Boven, H., Morente, M.M., Alonso, S., Kerjaschki, D., Pammer, J., Carbone, A., Gloghini, A., Teodorovic, I., Isabelle, M., Passioukov, A., Lejeune, S., Therasse, P., van Veen, E.-B., Dinjens, W.N.M., and Llombart-Bosch, A.

Published
2006
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156. TuBaFrost 3: Regulatory and ethical issues on the exchange of residual tissue for research across Europe

Author

van Veen, E.-B., Riegman, P.H.J., Dinjens, W.N.M., Lam, K.H., Oomen, M.H.A., Spatz, A., Mager, R., Ratcliffe, C., Knox, K., Kerr, D., van Damme, B., van de Vijver, M., van Boven, H., Morente, M.M., Alonso, S., Kerjaschki, D., Pammer, J., Lopez-Guerrero, J.A., Llombart Bosch, A., Carbone, A., Gloghini, A., Teodorovic, I., Isabelle, M., Passioukov, A., Lejeune, S., Therasse, P., and Oosterhuis, J.W.

Published
2006
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157. TuBaFrost 1: Uniting local Frozen Tumour Banks into a European Network: an overview

Author

Riegman, P.H.J., Dinjens, W.N.M., Oomen, M.H.A., Spatz, A., Ratcliffe, C., Knox, K., Mager, R., Kerr, D., Pezzella, F., van Damme, B., van de Vijver, M., van Boven, H., Morente, M.M., Alonso, S., Kerjaschki, D., Pammer, J., Lopez-Guerrero, J.A., Llombart Bosch, A., Carbone, A., Gloghini, A., Teodorovic, I., Isabelle, M., Jaminé, D., Passioukov, A., Lejeune, S., Therasse, P., van Veen, E.-B., Lam, K.H., and Oosterhuis, J.W.

Published
2006
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158. TuBaFrost 2: Standardising tissue collection and quality control procedures for a European virtual frozen tissue bank network

Author

Morente, M.M., Mager, R., Alonso, S., Pezzella, F., Spatz, A., Knox, K., Kerr, D., Dinjens, W.N.M., Oosterhuis, J.W., Lam, K.H., Oomen, M.H.A., van Damme, B., van de Vijver, M., van Boven, H., Kerjaschki, D., Pammer, J., Lopez-Guerrero, J.A., Llombart Bosch, A., Carbone, A., Gloghini, A., Teodorovic, I., Isabelle, M., Passioukov, A., Lejeune, S., Therasse, P., van Veen, E.-B., Ratcliffe, C., and Riegman, P.H.J.

Published
2006
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162. Tumor response assessment by modified Choi criteria in localized high-risk soft tissue sarcoma treated with chemotherapy

Author

Stacchiotti, Silvia, Verderio, Paolo, Messina, Antonella, Morosi, Carlo, Collini, Paola, Llombart-Bosch, Antonio, Martin, Javier, Comandone, Alessandro, Cruz, Jurado, Ferraro, Andrea, Grignani, Giovanni, Pizzamiglio, Sara, Quagliuolo, Vittorio, Picci, Piero, Frustaci, Sergio, Dei Tos, Angelo Paolo, Casali, Paolo G., and Gronchi, Alessandro

Published
2012
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173. miR-486 Expression is Regulated by DNA Methylation in Osteosarcoma

Author

Namløs, Heidi, primary, Skårn, Magne, additional, Ahmed, Deeqa, additional, Grad, Iwona, additional, Andresen, Kim, additional, Kresse, Stine, additional, Serra, Massimo, additional, Scotlandi, Katia, additional, Llombart-Bosch, Antonio, additional, Myklebost, Ola, additional, Lind, Guro, additional, and Meza-Zepeda, Leonardo, additional

Published
2020
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180. TuBaFrost: European Virtual Tumor Tissue Banking

Author

Riegman, P. H. J., primary, Oomen, M. H. A., additional, Dinjens, W. N. M., additional, Oosterhuis, J. W., additional, Lam, K. H., additional, Spatz, A., additional, Ratcliffe, C., additional, Knox, K., additional, Mager, R., additional, Kerr, D., additional, Pezzella, F., additional, van Damme, B., additional, van de Vijver, M., additional, van Boven, H., additional, Morente, M. M., additional, Alonso, S., additional, Kerjaschki, D., additional, Pammer, J., additional, López-Guerrero, J. A., additional, Llombart-Bosch, A., additional, Carbone, A., additional, Gloghini, A., additional, Teodorovic, I., additional, Isabelle, M., additional, Passioukov, A., additional, Lejeune, S., additional, Therasse, P., additional, and van Veen, E.-B., additional

Published
2006
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181. Immunohistochemical analysis of NKX2.2, ETV4, and BCOR in a large series of genetically confirmed Ewing sarcoma family of tumors

Author

José Antonio López-Guerrero, Antonio Llombart-Bosch, Akihiko Yoshida, Piero Picci, Isidro Machado, Samuel Navarro, and María Gema Nieto

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, CD99, Bone Neoplasms, Context (language use), Sarcoma, Ewing, Biology, Pathology and Forensic Medicine, Fusion gene, 03 medical and health sciences, 0302 clinical medicine, Proto-Oncogene Proteins, Biomarkers, Tumor, medicine, Humans, Neoplasm, Homeodomain Proteins, Proto-Oncogene Proteins c-ets, Nuclear Proteins, Cell Biology, Zebrafish Proteins, medicine.disease, Immunohistochemistry, Repressor Proteins, Homeobox Protein Nkx-2.2, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Adenovirus E1A Proteins, Sarcoma, Morphologic diagnosis, Antibody, Transcription Factors
Abstract

Ewing sarcoma is an aggressive neoplasm of pediatric and adolescent patients. Immunohistochemistry (IHC) can be used to support the morphologic diagnosis of Ewing sarcoma family of tumors (ESFT) in a convincing clinical/radiological context. Although neither NKX2.2 nor CD99 alone are entirely specific, when combined, the diagnostic specificity is high. The aim of the present study was to investigate the IHC expression of NKX2.2, ETV4 and BCOR in a large series of genetically confirmed ESFT. The results for CD99 and CAV-1 immunoreactivity, and the histological and fusion gene subtypes were retrieved from our previous study. NKX2.2 demonstrated moderate or strong nuclear positivity in 91.2% of the tumors. The staining intensity was heterogeneous. Many of the ESFT with negative NKX2.2 immunoreactivity were in bone. Strong/moderate ETV4 nuclear expression was detected in two small round cell tumors, both were negative for NKX2.2. No relationships could be found between expression of NKX2.2 and the histological subgroups or ESFT gene fusion subtypes. BCOR was negative in all ESFT. In conclusion, NKX2.2, ETV4 and BCOR IHC may be helpful in daily practice for distinguishing ESFT from CIC or BCOR-associated sarcomas, especially in hospitals without access to molecular assays. In addition, the combination of strong CD99 membranous positivity and nuclear NKX2.2 positivity seems to be very reliable for ESFT diagnosis in an appropriate clinicoradiological setting. So far no antibody is entirely specific for ESFT diagnosis, and the IHC or molecular results in round cell tumors of bone may be strongly influenced by decalcification processes.

Published
2017
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182. Desmoplastic melanoma may mimic a cutaneous peripheral nerve sheath tumor: Report of 3 challenging cases

Author

Celia Requena, Julia Cruz, Isidro Machado, Beatriz Llombart, Eduardo Nagore, Victor Traves, Antonio Llombart-Bosch, Carlos Monteagudo, and Antonina Parafioriti

Subjects
Desmoplastic melanoma, Pathology, medicine.medical_specialty, Histology, integumentary system, business.industry, Melanoma, Dermatology, medicine.disease, Pathology and Forensic Medicine, Benign tumor, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Dermis, 030220 oncology & carcinogenesis, medicine, Neurofibroma, Immunohistochemistry, Neurofibromatosis, business, Peripheral Nerve Sheath
Abstract

Desmoplastic melanoma (DM) and cutaneous malignant peripheral nerve sheath tumors (MPNST) reveal histological and immunohistochemical similarities, including S100 positivity and negative staining for conventional melanocytic markers. We present 3 cases of cutaneous S100-positive spindle cell tumors in elderly patients, in which first findings led to initial misdiagnoses as cutaneous MPNST and benign peripheral sheath nerve tumor (neurofibroma). The identification of adjacent atypical melanocytic hyperplasia in the overlying skin along with tumor cell proliferation, also in the superficial dermis, the neurotropic component and the absence of any relationship between the tumor and a major nerve, pre-existing neural benign tumor or the existence of stigmata suggestive of neurofibromatosis raised consideration of a DM. Careful attention should be paid to the presence of a firm dermal nodule and atypical scar lesions especially in sun-exposed areas (mainly head and neck region) in elderly patients associated with S100-positive spindle cell proliferation, solar elastosis and adjacent atypical melanocytic proliferation. In such cases, the possibility of a DM should be excluded with caution, especially if the tumor reveals a paucicellular morphology resembling various non-melanocytic neoplasms including malignant or benign peripheral sheath nerve tumors.

Published
2017
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188. Angiosarcomas: histology, immunohistochemistry and molecular insights with implications for differential diagnosis

Author

Machado I, Giner F, Lavernia J, Cruz J, Traves V, Requena C, Llombart B, López-Guerrero JA, and Llombart-Bosch A

Subjects
Molecular biology, Differential diagnosis, Angiosarcomas, Immunohistochemistry
Abstract

Angiosarcomas (AS) represent a heterogenous group of tumors with variable clinical presentation. AS share an important morphologic and immunohistochemical overlap with other sarcomas, hence the differential diagnosis is challenging, especially in poorly-differentiated tumors. Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. In this review, we discuss pathological and molecular insights with emphasis on implications for differential diagnosis in cutaneous, breast, soft tissue and visceral AS.

Published
2020

189. Controversial issues in soft tissue solitary fibrous tumors: A pathological and molecular review

Author

Machado I, Nieto-Morales G, Cruz J, Navarro S, Giner F, Ferrandez A, Lopez-Soto M, Lavernia J, and Llombart-Bosch A

Subjects
immunohistochemistry, morphology, solitary fibrous tumor, immunohistochemistry, molecular biology and risk stratification systems, morphology, solitary fibrous tumor, molecular biology and risk stratification systems
Abstract

The clinical evolution of solitary fibrous tumor (SFT) remains unclear. Although various clinical, morphological and molecular criteria may indicate increased risk of malignancy, some SFT can still progress despite having a clearly benign appearance. Various risk stratification systems have been proposed, but unfortunately they are not sufficient to precisely determine the malignant potential. In this review, we discuss current knowledge on SFT, focusing on the following controversial issues: (i) the diverse morphologic spectrum: 'the great simulator;' (ii) malignant transformation or dedifferentiation; (iii) current risk stratification systems; and (iv) molecular factors associated with clinical evolution. The morphological spectrum of SFT and the list of differential diagnoses continue to expand. Both have increased considerably since the first descriptions of specific molecular alterations. A classification of malignant SFT should not be based on histology alone. The correlation of all pathological and molecular factors is recommended; its inclusion in risk stratification systems may help to improve diagnosis and prognosis.

Published
2020

197. Deletions Affecting Codons 557-558 of the c-KIT Gene Indicate a Poor Prognosis in Patients With Completely Resected Gastrointestinal Stromal Tumors: A Study by the Spanish Group for Sarcoma Research (GEIS)

Author

Martín, Javier, Poveda, Andrés, Llombart-Bosch, Antonio, Ramos, Rafael, López-Guerrero, José A., del Muro, Javier García, Maurel, Joan, Calabuig, Silvia, Gutierrez, Antonio, de Sande, José L. González, Martínez, Javier, De Juan, Ana, Laínez, Nuria, Losa, Ferrán, Alija, Valentín, Escudero, Pilar, Casado, Antonio, García, Pilar, Blanco, Remei, and Buesa, José M.

Published
2005
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