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Computational cytology is a critical, rapid-developing, yet challenging topic in the field of medical image computing which analyzes the digitized cytology image by computer-aided technologies for cancer screening. Recently, an increasing number of deep learning (DL) algorithms have made significant progress in medical image analysis, leading to the boosting publications of cytological studies. To investigate the advanced methods and comprehensive applications, we survey more than 120 publications of DL-based cytology image analysis in this article. We first introduce various deep learning methods, including fully supervised, weakly supervised, unsupervised, and transfer learning. Then, we systematically summarize the public datasets, evaluation metrics, versatile cytology image analysis applications including classification, detection, segmentation, and other related tasks. Finally, we discuss current challenges and potential research directions of computational cytology.

So far, named entity recognition (NER) has been involved with three major types, including flat, overlapped (aka. nested), and discontinuous NER, which have mostly been studied individually. Recently, a growing interest has been built for unified NER, tackling the above three jobs concurrently with one single model. Current best-performing methods mainly include span-based and sequence-to-sequence models, where unfortunately the former merely focus on boundary identification and the latter may suffer from exposure bias. In this work, we present a novel alternative by modeling the unified NER as word-word relation classification, namely W^2NER. The architecture resolves the kernel bottleneck of unified NER by effectively modeling the neighboring relations between entity words with Next-Neighboring-Word (NNW) and Tail-Head-Word-* (THW-*) relations. Based on the W^2NER scheme we develop a neural framework, in which the unified NER is modeled as a 2D grid of word pairs. We then propose multi-granularity 2D convolutions for better refining the grid representations. Finally, a co-predictor is used to sufficiently reason the word-word relations. We perform extensive experiments on 14 widely-used benchmark datasets for flat, overlapped, and discontinuous NER (8 English and 6 Chinese datasets), where our model beats all the current top-performing baselines, pushing the state-of-the-art performances of unified NER., Comment: Accepted by AAAI'22

Adversarial training (AT) is considered to be one of the most reliable defenses against adversarial attacks. However, models trained with AT sacrifice standard accuracy and do not generalize well to novel attacks. Recent works show generalization improvement with adversarial samples under novel threat models such as on-manifold threat model or neural perceptual threat model. However, the former requires exact manifold information while the latter requires algorithm relaxation. Motivated by these considerations, we exploit the underlying manifold information with Normalizing Flow, ensuring that exact manifold assumption holds. Moreover, we propose a novel threat model called Joint Space Threat Model (JSTM), which can serve as a special case of the neural perceptual threat model that does not require additional relaxation to craft the corresponding adversarial attacks. Under JSTM, we develop novel adversarial attacks and defenses. The mixup strategy improves the standard accuracy of neural networks but sacrifices robustness when combined with AT. To tackle this issue, we propose the Robust Mixup strategy in which we maximize the adversity of the interpolated images and gain robustness and prevent overfitting. Our experiments show that Interpolated Joint Space Adversarial Training (IJSAT) achieves good performance in standard accuracy, robustness, and generalization in CIFAR-10/100, OM-ImageNet, and CIFAR-10-C datasets. IJSAT is also flexible and can be used as a data augmentation method to improve standard accuracy and combine with many existing AT approaches to improve robustness., Comment: Under submission

Recent studies have shown that robustness to adversarial attacks can be transferred across networks. In other words, we can make a weak model more robust with the help of a strong teacher model. We ask if instead of learning from a static teacher, can models "learn together" and "teach each other" to achieve better robustness? In this paper, we study how interactions among models affect robustness via knowledge distillation. We propose mutual adversarial training (MAT), in which multiple models are trained together and share the knowledge of adversarial examples to achieve improved robustness. MAT allows robust models to explore a larger space of adversarial samples, and find more robust feature spaces and decision boundaries. Through extensive experiments on CIFAR-10 and CIFAR-100, we demonstrate that MAT can effectively improve model robustness and outperform state-of-the-art methods under white-box attacks, bringing $\sim$8% accuracy gain to vanilla adversarial training (AT) under PGD-100 attacks. In addition, we show that MAT can also mitigate the robustness trade-off among different perturbation types, bringing as much as 13.1% accuracy gain to AT baselines against the union of $l_\infty$, $l_2$ and $l_1$ attacks. These results show the superiority of the proposed method and demonstrate that collaborative learning is an effective strategy for designing robust models., Comment: Under submission

Object detection plays a key role in many security-critical systems. Adversarial patch attacks, which are easy to implement in the physical world, pose a serious threat to state-of-the-art object detectors. Developing reliable defenses for object detectors against patch attacks is critical but severely understudied. In this paper, we propose Segment and Complete defense (SAC), a general framework for defending object detectors against patch attacks through detection and removal of adversarial patches. We first train a patch segmenter that outputs patch masks which provide pixel-level localization of adversarial patches. We then propose a self adversarial training algorithm to robustify the patch segmenter. In addition, we design a robust shape completion algorithm, which is guaranteed to remove the entire patch from the images if the outputs of the patch segmenter are within a certain Hamming distance of the ground-truth patch masks. Our experiments on COCO and xView datasets demonstrate that SAC achieves superior robustness even under strong adaptive attacks with no reduction in performance on clean images, and generalizes well to unseen patch shapes, attack budgets, and unseen attack methods. Furthermore, we present the APRICOT-Mask dataset, which augments the APRICOT dataset with pixel-level annotations of adversarial patches. We show SAC can significantly reduce the targeted attack success rate of physical patch attacks. Our code is available at https://github.com/joellliu/SegmentAndComplete., Comment: CVPR 2022 camera ready

Multi-label image classification is a fundamental but challenging task in computer vision. Over the past few decades, solutions exploring relationships between semantic labels have made great progress. However, the underlying spatial-contextual information of labels is under-exploited. To tackle this problem, a spatial-context-aware deep neural network is proposed to predict labels taking into account both semantic and spatial information. This proposed framework is evaluated on Microsoft COCO and PASCAL VOC, two widely used benchmark datasets for image multi-labelling. The results show that the proposed approach is superior to the state-of-the-art solutions on dealing with the multi-label image classification problem.

Humans can naturally and effectively find salient regions in complex scenes. Motivated by this observation, attention mechanisms were introduced into computer vision with the aim of imitating this aspect of the human visual system. Such an attention mechanism can be regarded as a dynamic weight adjustment process based on features of the input image. Attention mechanisms have achieved great success in many visual tasks, including image classification, object detection, semantic segmentation, video understanding, image generation, 3D vision, multi-modal tasks and self-supervised learning. In this survey, we provide a comprehensive review of various attention mechanisms in computer vision and categorize them according to approach, such as channel attention, spatial attention, temporal attention and branch attention; a related repository https://github.com/MenghaoGuo/Awesome-Vision-Attentions is dedicated to collecting related work. We also suggest future directions for attention mechanism research., Comment: 27 pages, 9 figures

Anomaly detection in medical images refers to the identification of abnormal images with only normal images in the training set. Most existing methods solve this problem with a self-reconstruction framework, which tends to learn an identity mapping and reduces the sensitivity to anomalies. To mitigate this problem, in this paper, we propose a novel Proxy-bridged Image Reconstruction Network (ProxyAno) for anomaly detection in medical images. Specifically, we use an intermediate proxy to bridge the input image and the reconstructed image. We study different proxy types, and we find that the superpixel-image (SI) is the best one. We set all pixels' intensities within each superpixel as their average intensity, and denote this image as SI. The proposed ProxyAno consists of two modules, a Proxy Extraction Module and an Image Reconstruction Module. In the Proxy Extraction Module, a memory is introduced to memorize the feature correspondence for normal image to its corresponding SI, while the memorized correspondence does not apply to the abnormal images, which leads to the information loss for abnormal image and facilitates the anomaly detection. In the Image Reconstruction Module, we map an SI to its reconstructed image. Further, we crop a patch from the image and paste it on the normal SI to mimic the anomalies, and enforce the network to reconstruct the normal image even with the pseudo abnormal SI. In this way, our network enlarges the reconstruction error for anomalies. Extensive experiments on brain MR images, retinal OCT images and retinal fundus images verify the effectiveness of our method for both image-level and pixel-level anomaly detection., Comment: This paper is accepted to IEEE TMI