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152. Supplementary Methods and Materials, Tables 1-4, Figure Legends 1-3 from Functional and Clinical Evidence for NDRG2 as a Candidate Suppressor of Liver Cancer Metastasis

Author

Lee, Dong Chul, primary, Kang, Yun Kyung, primary, Kim, Woo Ho, primary, Jang, Ye Jin, primary, Kim, Dong Joon, primary, Park, In Young, primary, Sohn, Bo Hwa, primary, Sohn, Hyun Ahm, primary, Lee, Hee Gu, primary, Lim, Jong Seok, primary, Kim, Jae Wha, primary, Song, Eun Young, primary, Kim, Dong Min, primary, Lee, Mi-Ni, primary, Oh, Goo Taeg, primary, Kim, Soo Jung, primary, Park, Kyung Chan, primary, Yoo, Hyang Sook, primary, Choi, Jong Young, primary, and Yeom, Young Il, primary

Published
2023
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153. Supplementary Figure 3 from Functional and Clinical Evidence for NDRG2 as a Candidate Suppressor of Liver Cancer Metastasis

Author

Lee, Dong Chul, primary, Kang, Yun Kyung, primary, Kim, Woo Ho, primary, Jang, Ye Jin, primary, Kim, Dong Joon, primary, Park, In Young, primary, Sohn, Bo Hwa, primary, Sohn, Hyun Ahm, primary, Lee, Hee Gu, primary, Lim, Jong Seok, primary, Kim, Jae Wha, primary, Song, Eun Young, primary, Kim, Dong Min, primary, Lee, Mi-Ni, primary, Oh, Goo Taeg, primary, Kim, Soo Jung, primary, Park, Kyung Chan, primary, Yoo, Hyang Sook, primary, Choi, Jong Young, primary, and Yeom, Young Il, primary

Published
2023
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154. Supplementary Figure 1 from Functional and Clinical Evidence for NDRG2 as a Candidate Suppressor of Liver Cancer Metastasis

Author

Lee, Dong Chul, primary, Kang, Yun Kyung, primary, Kim, Woo Ho, primary, Jang, Ye Jin, primary, Kim, Dong Joon, primary, Park, In Young, primary, Sohn, Bo Hwa, primary, Sohn, Hyun Ahm, primary, Lee, Hee Gu, primary, Lim, Jong Seok, primary, Kim, Jae Wha, primary, Song, Eun Young, primary, Kim, Dong Min, primary, Lee, Mi-Ni, primary, Oh, Goo Taeg, primary, Kim, Soo Jung, primary, Park, Kyung Chan, primary, Yoo, Hyang Sook, primary, Choi, Jong Young, primary, and Yeom, Young Il, primary

Published
2023
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156. Supplementary Figure 2 from Functional and Clinical Evidence for NDRG2 as a Candidate Suppressor of Liver Cancer Metastasis

Author

Lee, Dong Chul, primary, Kang, Yun Kyung, primary, Kim, Woo Ho, primary, Jang, Ye Jin, primary, Kim, Dong Joon, primary, Park, In Young, primary, Sohn, Bo Hwa, primary, Sohn, Hyun Ahm, primary, Lee, Hee Gu, primary, Lim, Jong Seok, primary, Kim, Jae Wha, primary, Song, Eun Young, primary, Kim, Dong Min, primary, Lee, Mi-Ni, primary, Oh, Goo Taeg, primary, Kim, Soo Jung, primary, Park, Kyung Chan, primary, Yoo, Hyang Sook, primary, Choi, Jong Young, primary, and Yeom, Young Il, primary

Published
2023
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158. Data from Functional and Clinical Evidence for NDRG2 as a Candidate Suppressor of Liver Cancer Metastasis

Author

Lee, Dong Chul, primary, Kang, Yun Kyung, primary, Kim, Woo Ho, primary, Jang, Ye Jin, primary, Kim, Dong Joon, primary, Park, In Young, primary, Sohn, Bo Hwa, primary, Sohn, Hyun Ahm, primary, Lee, Hee Gu, primary, Lim, Jong Seok, primary, Kim, Jae Wha, primary, Song, Eun Young, primary, Kim, Dong Min, primary, Lee, Mi-Ni, primary, Oh, Goo Taeg, primary, Kim, Soo Jung, primary, Park, Kyung Chan, primary, Yoo, Hyang Sook, primary, Choi, Jong Young, primary, and Yeom, Young Il, primary

Published
2023
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166. Clinical and Vessel Characteristics Associated With Hard Outcomes After PCI and Their Combined Prognostic Implications

Author

Yang, Seokhun, Hwang, Doyeon, Zhang, Jinlong, Park, Jiesuck, Yun, Jun Pil, Lee, Joo Myung, Nam, Chang Wook, Shin, Eun Seok, Doh, Joon Hyung, Chen, Shao Liang, Kakuta, Tsunekazu, Toth, Gabor G., Piroth, Zsolt, Johnson, Nils P., Hakeem, Abdul, Uretsky, Barry F., Hokama, Yohei, Tanaka, Nobuhiro, Lim, Hong Seok, Ito, Tsuyoshi, Matsuo, Akiko, Azzalini, Lorenzo, Leesar, Massoud A., Neleman, Tara, van Mieghem, Nicolas M., Diletti, Roberto, Daemen, Joost, Collison, Damien, Collet, Carlos, De Bruyne, Bernard, Koo, Bon Kwon, Yang, Seokhun, Hwang, Doyeon, Zhang, Jinlong, Park, Jiesuck, Yun, Jun Pil, Lee, Joo Myung, Nam, Chang Wook, Shin, Eun Seok, Doh, Joon Hyung, Chen, Shao Liang, Kakuta, Tsunekazu, Toth, Gabor G., Piroth, Zsolt, Johnson, Nils P., Hakeem, Abdul, Uretsky, Barry F., Hokama, Yohei, Tanaka, Nobuhiro, Lim, Hong Seok, Ito, Tsuyoshi, Matsuo, Akiko, Azzalini, Lorenzo, Leesar, Massoud A., Neleman, Tara, van Mieghem, Nicolas M., Diletti, Roberto, Daemen, Joost, Collison, Damien, Collet, Carlos, De Bruyne, Bernard, and Koo, Bon Kwon

Abstract

Background:Cardiac death or myocardial infarction still occurs in patients undergoing contemporary percutaneous coronary intervention (PCI). We aimed to identify adverse clinical and vessel characteristics related to hard outcomes after PCI and to investigate their individual and combined prognostic implications. Methods and Results:From an individual patient data meta-analysis of 17 cohorts of patients who underwent post-PCI fractional flow reserve measurement after drug-eluting stent implantation, 2081 patients with available clinical and vessel characteristics were analyzed. The primary outcome was cardiac death or target-vessel myocardial infarction at 2 years. The mean age of patients was 64.2±10.2 years, and the mean angiographic percent diameter stenosis was 63.9%±14.3%. Among 11 clinical and 8 vessel features, 4 adverse clinical characteristics (age ≥65 years, diabetes, chronic kidney disease, and left ventricular ejection fraction <50%) and 2 adverse vessel characteristics (post-PCI fractional flow reserve ≤0.80 and total stent length ≥54 mm) were identified to independently predict the primary outcome (all P<0.05). The number of adverse vessel characteristics had additive predictability for the primary end point to that of adverse clinical characteristics (area under the curve 0.72 versus 0.78; P=0.03) and vice versa (area under the curve 0.68 versus 0.78; P=0.03). The cumulative event rate increased in the order of none, either, and both of adverse clinical characteristics ≥2 and adverse vessel characteristics ≥1 (0.3%, 2.4%, and 5.3%; P for trend <0.01). Conclusions:In patients undergoing drug-eluting stent implantation, adverse clinical and vessel characteristics were associated with the risk of cardiac death or target-vessel myocardial infarction. Because these characteristics showed independent and additive prognostic value, their integrative assessment can optimize post-PCI risk stra

Published
2023

167. Pharmacokinetic Interactions Between Bazedoxifene and Cholecalciferol: An Open-Label, Randomized, Crossover Study in Healthy Male Volunteers

Author

Lee,Moon Hee, Yoon,Seok-Kyu, Kim,Hyungsub, Cho,Yong-Soon, Han,Sungpil, Lee,Shi Hyang, Bae,Kyun-Seop, Jung,Jina, Hong,Sung Hee, Lim,Hyeong-Seok, Lee,Moon Hee, Yoon,Seok-Kyu, Kim,Hyungsub, Cho,Yong-Soon, Han,Sungpil, Lee,Shi Hyang, Bae,Kyun-Seop, Jung,Jina, Hong,Sung Hee, and Lim,Hyeong-Seok

Abstract

Moon Hee Lee,1 Seok-Kyu Yoon,1 Hyungsub Kim,2 Yong-Soon Cho,3 Sungpil Han,4 Shi Hyang Lee,1 Kyun-Seop Bae,1 Jina Jung,5 Sung Hee Hong,5 Hyeong-Seok Lim1 1Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan, Seoul, Republic of Korea; 2Department of Emergency Medical Services, College of Health Sciences, Eulji University, Seongnam, Republic of Korea; 3Department of Pharmacology and Clinical Pharmacology, Inje University College of Medicine, Busan, Republic of Korea; 4Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; 5Hanmi Pharmaceutical Co. Ltd., Seoul, Republic of KoreaCorrespondence: Hyeong-Seok Lim, Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea, Tel +82-2-3010-4613, Fax +82-2-3010-4623, Email mdlhs@amc.seoul.krPurpose: The combined administration of bazedoxifene, a tissue-selective estrogen receptor modulator, and cholecalciferol can be a promising therapeutic option for postmenopausal osteoporosis patients. This study aimed to examine the pharmacokinetic interactions between these two drugs and the tolerability of their combined administration in healthy male subjects.Patients and Methods: Thirty male volunteers were randomly assigned to one of the six sequences comprised of three treatments: bazedoxifene 20 mg monotherapy, cholecalciferol 1600 IU monotherapy, and combined bazedoxifene and cholecalciferol therapy. For each treatment, a single dose of the investigational drug(s) was administered orally, and serial blood samples were collected to measure the plasma concentrations of bazedoxifene and cholecalciferol. Pharmacokinetic parameters were calculated using the non-compartmental method. The point estimate and 90% confidence interval (CI) of the geometric mean ratio (GMR) were obtained to compare the exposures of combined therapy and monotherapy.

Published
2023

185. Effect of Cr Content on Hot Corrosion Behavior of Inconel Alloys in Molten LiCl–Li2O.

Author

Lim, Kyu-Seok, Choi, Woo-Seok, Kim, Wan-Bae, Cho, Soo-Haeng, and Lee, Jong-Hyeon

Subjects
*LIQUID alloys, *ALLOY testing, *INCONEL, *CORROSION resistance, *NUCLEAR power plants, *FUSED salts, *CORROSION in alloys
Abstract

The hot corrosion behaviors of Inconel alloys with different Cr contents (Inconel 600, 601, and 690), which are used widely in nuclear plants, were investigated in molten LiCl–Li2O salts. The hot corrosion behaviors were studied by measuring the mass and attack depth changes, surface and cross-sectional morphologies and elemental distributions, and compositional changes at the subscale and substrate scale as well as the spalled oxide scale. At 288 h, the weight losses of Inconel 601 and Inconel 690 were approximately four and twelve times higher, respectively, than that of Inconel 600. The corrosion products of all tested alloys were Cr2O3, NiO, and FeCr2O4. Inconel 600, which exhibited a dense and continuous external corrosion layer and an internal corrosion layer with localized corrosion behavior, exhibited superior corrosion resistance compared with those of Inconel 601 and 690, which showed a spalled external corrosion layer and an internal corrosion layer with uniform corrosion behavior. Thus, the corrosion resistance of the Inconel alloys tested in the hot lithium molten salts in an oxidizing atmosphere is closely related to the contents of the primary alloying elements in the alloys. Of the various alloys analyzed in this study, Inconel 600 exhibited the highest corrosion resistance. Thus, a Cr content of 16.30 wt% or less, Ni content of at least 73.66 wt%, and Fe content considerably lower than 8.15 wt% can result in excellent corrosion resistance. [ABSTRACT FROM AUTHOR]

Published
2023
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186. Early Use of Low-dose Ticagrelor-based Dual Antiplatelet Therapy and Clinical Outcomes in Patients Undergoing Percutaneous Coronary Interventions for Complex Lesions

Author

Lee, Yonggu, primary, Shin, Jeong-Hun, additional, Seo, Suk Min, additional, Choi, Ik Jun, additional, Lee, Jong-Young, additional, Lee, Jun-Won, additional, Park, Mahn-Won, additional, Kang, Tae Soo, additional, Choi, Woong Gil, additional, Jeon, Ki-Hyun, additional, Lim, Hong-Seok, additional, Joo, Hyung Joon, additional, Rhee, Sang Jae, additional, Seo, Jae-Bin, additional, Park, Myung Soo, additional, Park, Sang-Ho, additional, and Lim, Young-Hyo, additional

Published
2023
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188. Prasugrel dose de-escalation in diabetic patients with acute coronary syndrome receiving percutaneous coronary intervention: Results from HOST-REDUCE-POLYTECH-ACS trial

Author

Lee, Kyu-Sun, primary, Park, Keun-Ho, additional, Park, Kyung Woo, additional, Rha, Seung-Woon, additional, Hwang, Doyeon, additional, Kang, Jeehoon, additional, Han, Jung-Kyu, additional, Yang, Han-Mo, additional, Kang, Hyun-Jae, additional, Koo, Bon-Kwon, additional, Lee, Nam-ho, additional, Rhew, Jay Young, additional, Chun, Kook Jin, additional, Lim, Young-Hyo, additional, Bong, Jung Min, additional, Bae, Jang-Whan, additional, Lee, Bong Ki, additional, Kim, Seok-Yeon, additional, Shin, Won-Yong, additional, Lim, Hong-Seok, additional, Park, Kyungil, additional, and Kim, Hyo-Soo, additional

Published
2023
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191. Machine Learning-Based Mortality Prediction Model for Critically Ill Cancer Patients Admitted to the Intensive Care Unit (CanICU)

Author

Ko, Ryoung-Eun, primary, Cho, Jaehyeong, additional, Shin, Min-Kyue, additional, Oh, Sung Woo, additional, Seong, Yeonchan, additional, Jeon, Jeongseok, additional, Jeon, Kyeongman, additional, Paik, Soonmyung, additional, Lim, Joon Seok, additional, Shin, Sang Joon, additional, Ahn, Joong Bae, additional, Park, Jong Hyuck, additional, You, Seng Chan, additional, and Kim, Han Sang, additional

Published
2023
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195. The relationship between intravascular ultrasound-derived percent total atheroma volume and fractional flow reserve in the intermediate stenosis of proximal or middle left anterior descending coronary artery

Author

Jin, Xiong Jie, Tahk, Seung-Jea, Yang, Hyoung-Mo, Lim, Hong-Seok, Yoon, Myeong-Ho, Choi, So-Yeon, Choi, Byoung-Joo, Hwang, Gyo-Seung, Seo, Kyoung-Woo, Shin, Jeoung-Sook, Lee, You-Hong, Choi, Yong-Woo, Park, Se-Jun, Park, Jin-Sun, and Shin, Joon-Han

Published
2015
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