Search

Your search keyword '"Licinio J"' showing total 1,225 results
Start Over Author "Licinio J"
1,225 results on '"Licinio J"'

151. The PHF21B gene is associated with major depression and modulates the stress response

Author

Wong, M-L, primary, Arcos-Burgos, M, additional, Liu, S, additional, Vélez, J I, additional, Yu, C, additional, Baune, B T, additional, Jawahar, M C, additional, Arolt, V, additional, Dannlowski, U, additional, Chuah, A, additional, Huttley, G A, additional, Fogarty, R, additional, Lewis, M D, additional, Bornstein, S R, additional, and Licinio, J, additional

Published
2016
Full Text
View/download PDF

154. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

Author

Zheng, P, primary, Zeng, B, additional, Zhou, C, additional, Liu, M, additional, Fang, Z, additional, Xu, X, additional, Zeng, L, additional, Chen, J, additional, Fan, S, additional, Du, X, additional, Zhang, X, additional, Yang, D, additional, Yang, Y, additional, Meng, H, additional, Li, W, additional, Melgiri, N D, additional, Licinio, J, additional, Wei, H, additional, and Xie, P, additional

Published
2016
Full Text
View/download PDF

159. Trial for the Prevention of Depression (TriPoD) in final-year secondary students: Study protocol for a cluster randomised controlled trial

Author

Perry, Y, Calear, AL, Mackinnon, A, Batterham, PJ, Licinio, J, King, C, Thomsen, N, Scott, J, Donker, T, Merry, S, Fleming, T, Stasiak, K, Werner-Seidler, A, Christensen, H, Perry, Y, Calear, AL, Mackinnon, A, Batterham, PJ, Licinio, J, King, C, Thomsen, N, Scott, J, Donker, T, Merry, S, Fleming, T, Stasiak, K, Werner-Seidler, A, and Christensen, H

Abstract

Background: Evidence suggests that current treatments cannot fully alleviate the burden of disease associated with depression but that prevention approaches offer a promising opportunity to further reduce this burden. Adolescence is a critical period in the development of mental illness, and final school examinations are a significant and nearly universal stressor that may act as a trigger for mental health difficulties such as depression. The aim of the present trial is to investigate the impact of SPARX-R, an online, gamified intervention based on cognitive behavioural principles, on the prevention of depression in secondary school students before their final examinations. Methods/Design: Government, independent and Catholic secondary schools in New South Wales, Australia, will be recruited to participate in the trial. All students enrolled in their final year of high school (year 12) in participating schools will be invited to participate. To account for possible attrition, the target sample size was set at 1600 participants across 30 schools. Participating schools will be cluster randomised at the school level to receive either SPARX-R or lifeSTYLE, an attention-controlled placebo comparator. The control intervention is an online program aimed at maintaining a healthy lifestyle. The primary outcome will be symptoms of depression, and secondary outcomes will include symptoms of anxiety, suicidal ideation and behaviours, stigma and academic performance. Additional measures of cost-effectiveness, as well as process variables (e.g., adherence, acceptability) and potential predictors of response to treatment, will be collected. Consenting parents will be invited to complete measures regarding their own mental health and expectations for their child. Assessments will be conducted pre- and post-intervention and at 6- and 18-month follow-up. Primary analyses will compare changes in levels of depressive symptomatology for the intervention group relative to the attention

Published
2015

163. APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease

Author

Vélez, J I, primary, Lopera, F, additional, Sepulveda-Falla, D, additional, Patel, H R, additional, Johar, A S, additional, Chuah, A, additional, Tobón, C, additional, Rivera, D, additional, Villegas, A, additional, Cai, Y, additional, Peng, K, additional, Arkell, R, additional, Castellanos, F X, additional, Andrews, S J, additional, Silva Lara, M F, additional, Creagh, P K, additional, Easteal, S, additional, de Leon, J, additional, Wong, M L, additional, Licinio, J, additional, Mastronardi, C A, additional, and Arcos-Burgos, M, additional

Published
2015
Full Text
View/download PDF

169. Leptin Mediates the Increase in Blood Pressure Associated with Obesity

Author

Simonds, SE, Pryor, JT, Ravussin, E, Greenway, FL, Dileone, R, Allen, AM, Bassi, J, Elmquist, JK, Keogh, JM, Henning, E, Myers, MG, Licinio, J, Brown, RD, Enriori, PJ, O'Rahilly, S, Sternson, SM, Grove, KL, Spanswick, DC, Farooqi, IS, Cowley, MA, Simonds, SE, Pryor, JT, Ravussin, E, Greenway, FL, Dileone, R, Allen, AM, Bassi, J, Elmquist, JK, Keogh, JM, Henning, E, Myers, MG, Licinio, J, Brown, RD, Enriori, PJ, O'Rahilly, S, Sternson, SM, Grove, KL, Spanswick, DC, Farooqi, IS, and Cowley, MA

Abstract

Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR). Furthermore, humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity. Leptin's effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight. Re-expression of LepRs in the DMH of DIO LepR-deficient mice caused an increase in BP. These studies demonstrate that leptin couples changes in weight to changes in BP in mammalian species.

Published
2014

173. When should governments increase the supply of psychiatric beds?

Author

Allison, S, Bastiampillai, T, Licinio, J, Fuller, D A, Bidargaddi, N, and Sharfstein, S S

Abstract

Low numbers of hospital-based psychiatric beds create problems for people with severe mental illness (SMI), when they face extended emergency department (ED) waits, higher thresholds for admission to an acute bed, and short revolving-door stays with high rates of rehospitalisation. Limited access to inpatient treatment has been associated with higher suicide risk, premature mortality, homelessness, violent crime and incarceration. Ultimately, people with SMI can be transinstitutionalised to the criminal justice system. In the USA, for example, prisons have replaced mental hospitals as the largest institutions housing people with SMI. There is no international consensus on the safe minimum numbers of acute, forensic and rehabilitation beds needed to reduce these risks. As a consequence, Organisation for Economic Cooperation and Development (OECD) countries have wide variations in the mix of hospital beds with an average of 71 beds per 100?000 population. Policymakers face difficult choices with few studies to guide decisions on supplying beds. The UK Royal College of Psychiatrists offered a policy framework, which was adapted for Australia. The government of the State of South Australia increased the supplies of crisis, acute and forensic beds to meet a mandatory target to safely reduce mental health boarding in the EDs.

Published
2018
Full Text
View/download PDF

174. Urinary Lipidomics: evidence for multiple sources and sexual dimorphism in healthy individuals

Author

Graessler, J, Mehnert, C S, Schulte, K-M, Bergmann, S, Strauss, S, Bornstein, T D, Licinio, J, Wong, M-L, Birkenfeld, A L, and Bornstein, S R

Abstract

Urinary lipidomics may add new valuable biomarkers to the diagnostic armamentarium for early detection of metabolic and kidney diseases. Sources and composition of urinary lipids in healthy individuals, however, have not been investigated in detail. Shotgun lipidomics was used to quantify lipidomic profiles in native urine samples from 16 individuals (eight men, eight women) collected in five fractions over 24?h. All probands were comprehensively characterized by urinary and clinical indices. The mean total urinary lipid concentration per sample was 0.84?µM in men and 1.03?µM in women. We observed significant intra- and interindividual variations of lipid concentrations over time, but failed to detect a clear circadian pattern. Based on quantity and subclass composition it seems very unlikely that plasma serves as major source for the urinary lipidome. Considering lipid metabolites occurring in at least 20% of all samples 38 lipid species from 7 lipid classes were identified. Four phosphatidylserine and one phosphatidylethanolamine ether species (PE-O 36:5) were detectable in almost all urine samples. Sexual dimorphism has been found mainly for phosphatidylcholines and phosphatidylethanolamines. In men and in women urinary lipid species were highly correlated with urinary creatinine and albumin excretion, reflecting glomerular filtration and tubular transport processes. In women, however, lipid species deriving from urinary cells and cellular constituents of the lower genitourinary tract considerably contributed to the urinary lipidome. In conclusion, our study revealed the potential of urinary lipidomics but also the complexity of methodological challenges which have to be overcome for its implementation as a routine diagnostic tool for renal, urological and metabolic diseases.

Published
2018
Full Text
View/download PDF

175. Circadian interleukin-6 secretion and quantity and depth of sleep

Author

Vgontzas, A.N. Papanicolaou, D.A. Bixler, E.O. Lotsikas, A. Zachman, K. Kales, A. Prolo, P. Wong, M.-L. Licinio, J. Gold, P.W. Hermida, R.C. Mastorakos, G. Chrousos, G.P.

Abstract

Patients with pathologically increased daytime sleepiness and fatigue have elevated levels of circulating interleukin-6 (IL-6). The latter is an inflammatory cytokine, which causes sickness manifestations, including somnolence and fatigue, and activation of the hypothalamic-pituitary-adrenal axis. In this study, we examined: 1) the relation between serial measurements of plasma IL-6 and quantity and depth of sleep, evaluated by polysomnography; and 2) the effects of sleep deprivation on the nyctohemeral pattern of IL-6 secretion. Eight healthy young male volunteers were sampled for 24 h twice, at the baseline state, after a normal night's sleep and after total overnight sleep deprivation. At the baseline state, IL-6 was secreted in a biphasic circadian pattern with two nadirs at 0800 and 2100 and two zeniths at 1900 and 0500 (P < 0.01). The baseline amount of sleep correlated negatively with the overall daytime secretion of the cytokine (P < 0.05). Also, depth of sleep at baseline correlated negatively with the postdeprivation increase of daytime secretion of IL-6 (P

Published
1999

176. Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes

Author

Graessler, J, primary, Bornstein, T D, additional, Goel, D, additional, Bhalla, V P, additional, Lohmann, T, additional, Wolf, T, additional, Koch, M, additional, Qin, Y, additional, Licinio, J, additional, Wong, M-L, additional, Chavakis, T, additional, Xu, A, additional, Shevchenko, A, additional, Schuhmann, K, additional, Schwarz, P E H, additional, Schulte, K-M, additional, Patel, A, additional, and Bornstein, S R, additional

Published
2013
Full Text
View/download PDF

182. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters

Author

Graessler, J, primary, Qin, Y, additional, Zhong, H, additional, Zhang, J, additional, Licinio, J, additional, Wong, M-L, additional, Xu, A, additional, Chavakis, T, additional, Bornstein, A B, additional, Ehrhart-Bornstein, M, additional, Lamounier-Zepter, V, additional, Lohmann, T, additional, Wolf, T, additional, and Bornstein, S R, additional

Published
2012
Full Text
View/download PDF

183. Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder

Author

Hornig, M, primary, Briese, T, additional, Licinio, J, additional, Khabbaz, R F, additional, Altshuler, L L, additional, Potkin, S G, additional, Schwemmle, M, additional, Siemetzki, U, additional, Mintz, J, additional, Honkavuori, K, additional, Kraemer, H C, additional, Egan, M F, additional, Whybrow, P C, additional, Bunney, W E, additional, and Lipkin, W I, additional

Published
2012
Full Text
View/download PDF

184. Chromaffin cells: the peripheral brain

Author

Bornstein, S R, primary, Ehrhart-Bornstein, M, additional, Androutsellis-Theotokis, A, additional, Eisenhofer, G, additional, Vukicevic, V, additional, Licinio, J, additional, Wong, M L, additional, Calissano, P, additional, Nisticò, G, additional, Preziosi, P, additional, and Levi-Montalcini, R, additional

Published
2012
Full Text
View/download PDF

185. Digital footprints: facilitating large-scale environmental psychiatric research in naturalistic settings through data from everyday technologies

Author

Bidargaddi, N, Musiat, P, Makinen, V-P, Ermes, M, Schrader, G, and Licinio, J

Abstract

Digital footprints, the automatically accumulated by-products of our technology-saturated lives, offer an exciting opportunity for psychiatric research. The commercial sector has already embraced the electronic trails of customers as an enabling tool for guiding consumer behaviour, and analogous efforts are ongoing to monitor and improve the mental health of psychiatric patients. The untargeted collection of digital footprints that may or may not be health orientated comprises a large untapped information resource for epidemiological scale research into psychiatric disorders. Real-time monitoring of mood, sleep and physical and social activity in a substantial portion of the affected population in a naturalistic setting is unprecedented in psychiatry. We propose that digital footprints can provide these measurements from real world setting unobtrusively and in a longitudinal fashion. In this perspective article, we outline the concept of digital footprints and the services and devices that create them, and present examples where digital footprints have been successfully used in research. We then critically discuss the opportunities and fundamental challenges associated digital footprints in psychiatric research, such as collecting data from different sources, analysis, ethical and research design challenges.

Published
2017
Full Text
View/download PDF

186. Reply to Liu et al.: Hypothalamic control of islets

Author

Schmid, J., primary, Ludwig, B., additional, Schally, A. V., additional, Steffen, A., additional, Ziegler, C. G., additional, Block, N. L., additional, Koutmani, Y., additional, Brendel, M. D., additional, Karalis, K. P., additional, Simeonovic, C. J., additional, Licinio, J., additional, Ehrhart-Bornstein, M., additional, and Bornstein, S. R., additional

Published
2011
Full Text
View/download PDF

190. The International HapMap Project

Author

Gibbs, RA, Belmont, JW, Hardenbol, P., Willis, TD, Yu, FL, Yang, HM, Ch'ang, LY, Huang, W., Liu, B., Shen, Y., Tam, PKH, Foster, MW, Jasperse, M., Knoppers, BM, Kwok, PY, Licinio, J., Long, JC, Marshall, PA, Ossorio, PN, Wang, VO, Rotimi, CN, Tsui, LC, Royal, CDM, Spallone, P., Terry, SF, Lander, ES, Lai, EH, Nickerson, DA, Abecasis, GR, Altshuler, D., Bentley, DR, Boehnke, M., Waye, MMY, Cardon, LR, Daly, MJ, Deloukas, P., Douglas, JA, Gabriel, SB, Hudson, RR, Hudson, TJ, Kruglyak, L., Nakamura, Y., Wong, JTF, Nussbaum, RL, Schaffner, SF, Sherry, ST, Stein, LD, Tanaka, T., Zeng, CQ, Zhang, QR, Chee, MS, Galver, LM, Kruglyak, S., Murray, SS, Oliphant, AR, Montpetit, A., Chagnon, F., Ferretti, V., Leboeuf, M., Phillips, MS, Verner, A., Duan, SH, Lind, DL, Miller, RD, Rice, JP, Saccone, NL, Taillon-Miller, P., Xiao, M., Sekine, A., Sorimachi, K., Tanaka, Y., Tsunoda, T., Yoshino, E., Hunt, S., Powell, D., Qiu, RZ, Ken, A., Dunston, GM, Kato, K., Niikawa, N., Clayton, EW, Watkin, J., Sodergren, E., Weinstock, GM, Wilson, RK, Fulton, LL, Rogers, J., Birren, BW, Han, H., Wang, HG, Godbout, M., Wallenburg, JC, L'Archeveque, P., Bellemare, G., Todani, K., Fujita, T., Tanaka, S., Holden, AL, Collins, FS, Brooks, LD, McEwen, JE, Guyer, MS, Jordan, E., Peterson, JL, Spiegel, J., Sung, LM, Zacharia, LF, Kennedy, K., Dunn, MG, Seabrook, R., Shillito, M., Skene, B., Stewart, JG, Valle, DL, Jorde, LB, Chakravarti, A., Cho, MK, Duster, T., Gibbs, RA, Belmont, JW, Hardenbol, P., Willis, TD, Yu, FL, Yang, HM, Ch'ang, LY, Huang, W., Liu, B., Shen, Y., Tam, PKH, Foster, MW, Jasperse, M., Knoppers, BM, Kwok, PY, Licinio, J., Long, JC, Marshall, PA, Ossorio, PN, Wang, VO, Rotimi, CN, Tsui, LC, Royal, CDM, Spallone, P., Terry, SF, Lander, ES, Lai, EH, Nickerson, DA, Abecasis, GR, Altshuler, D., Bentley, DR, Boehnke, M., Waye, MMY, Cardon, LR, Daly, MJ, Deloukas, P., Douglas, JA, Gabriel, SB, Hudson, RR, Hudson, TJ, Kruglyak, L., Nakamura, Y., Wong, JTF, Nussbaum, RL, Schaffner, SF, Sherry, ST, Stein, LD, Tanaka, T., Zeng, CQ, Zhang, QR, Chee, MS, Galver, LM, Kruglyak, S., Murray, SS, Oliphant, AR, Montpetit, A., Chagnon, F., Ferretti, V., Leboeuf, M., Phillips, MS, Verner, A., Duan, SH, Lind, DL, Miller, RD, Rice, JP, Saccone, NL, Taillon-Miller, P., Xiao, M., Sekine, A., Sorimachi, K., Tanaka, Y., Tsunoda, T., Yoshino, E., Hunt, S., Powell, D., Qiu, RZ, Ken, A., Dunston, GM, Kato, K., Niikawa, N., Clayton, EW, Watkin, J., Sodergren, E., Weinstock, GM, Wilson, RK, Fulton, LL, Rogers, J., Birren, BW, Han, H., Wang, HG, Godbout, M., Wallenburg, JC, L'Archeveque, P., Bellemare, G., Todani, K., Fujita, T., Tanaka, S., Holden, AL, Collins, FS, Brooks, LD, McEwen, JE, Guyer, MS, Jordan, E., Peterson, JL, Spiegel, J., Sung, LM, Zacharia, LF, Kennedy, K., Dunn, MG, Seabrook, R., Shillito, M., Skene, B., Stewart, JG, Valle, DL, Jorde, LB, Chakravarti, A., Cho, MK, and Duster, T.

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results