195 results on '"Li Zhenyuan"'
Search Results
152. Research on Collaborative Optimization Model of Park-level Integrated Energy System Participating in Power Peak Shaving
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Fan, Shanshan, primary, Wang, Bin, additional, Sun, Yong, additional, Sun, Hongbin, additional, Li, Zhenyuan, additional, Liu, Xin, additional, and Guo, Qinglai, additional
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- 2018
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153. Electrochemical CO2 Reduction with Atomic Iron‐Dispersed on Nitrogen‐Doped Graphene
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Zhang, Chenhao, primary, Yang, Shize, additional, Wu, Jingjie, additional, Liu, Mingjie, additional, Yazdi, Sadegh, additional, Ren, Muqing, additional, Sha, Junwei, additional, Zhong, Jun, additional, Nie, Kaiqi, additional, Jalilov, Almaz S., additional, Li, Zhenyuan, additional, Li, Huaming, additional, Yakobson, Boris I., additional, Wu, Qin, additional, Ringe, Emilie, additional, Xu, Hui, additional, Ajayan, Pulickel M., additional, and Tour, James M., additional more...
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- 2018
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154. Combined Economic Dispatch Considering the Time-Delay of District Heating Network and Multi-Regional Indoor Temperature Control
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Wu, Chenyu, primary, Gu, Wei, additional, Jiang, Ping, additional, Li, Zhenyuan, additional, Cai, Hongyi, additional, and Li, Baoju, additional
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- 2018
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155. Statistical Analysis and Fatigue Life Estimations for Quenched and Tempered Steel at Different Tempering Temperatures
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Li, Changyou, primary, Li, Shuangfeng, additional, Duan, Fei, additional, Wang, Yuewu, additional, Zhang, Yimin, additional, He, David, additional, Li, Zhenyuan, additional, and Wang, Wei, additional
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- 2017
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156. Pharmacological inhibition of heparin-binding EGF-like growth factor promotes peritoneal angiogenesis in a peritoneal dialysis rat model
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Li, Zhenyuan, primary, Yan, Hao, additional, Yuan, Jiangzi, additional, Cao, Liou, additional, Lin, Aiwu, additional, Dai, Huili, additional, Ni, Zhaohui, additional, Qian, Jiaqi, additional, and Fang, Wei, additional more...
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- 2017
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157. Feasibility of Urgent-Start Peritoneal Dialysis in Older Patients with End-Stage Renal Disease: A Single-Center Experience
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Jin, Haijiao, primary, Ni, Zhaohui, additional, Mou, Shan, additional, Lu, Renhua, additional, Fang, Wei, additional, Huang, Jiaying, additional, Hu, Chunhua, additional, Zhang, Haifen, additional, Yan, Hao, additional, Li, Zhenyuan, additional, and Yu, Zanzhe, additional more...
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- 2017
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158. Gradual Reliability Sensitivity Analysis of Mechanical Part Considering Preventive Maintenance
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Guo Song, Li Zhenyuan, Zhang Yi-min, Liu Haiyang, and Li Changyou
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Engineering ,Process (engineering) ,business.industry ,Sensitivity equation ,Mechanical Engineering ,lcsh:Mechanical engineering and machinery ,Gamma process ,Preventive maintenance ,Reliability engineering ,Mechanical system ,lcsh:TJ1-1570 ,Sensitivity (control systems) ,business ,Reliability model ,Reliability (statistics) - Abstract
A lot of mechanical parts are subject to failure due to the deterioration. Usually the preventive maintenance is taken to ensure the safety and reliability. Therefore, it is very important to study the gradual reliability design of the mechanical part for improving the gradual reliability of the mechanical system under the condition of considering the preventive maintenance. Beta distribution is employed to describe the randomness of the mechanical part state after the preventive maintenance. The deterioration process of the mechanical part is modeled using the nonstationary Gamma process. The gradual reliability model before the first preventive maintenance is proposed according to the gradual failure principle and using the initial state distribution and the properties of Gamma process. Then, the gradual reliability model between any two times of preventive maintenance is also derived. Subsequently, the sensitivity equations of the proposed gradual reliability model to each parameter are given. The application process and practicality of the proposed approach are described by a numerical example. This work solved the problem where the maintenance has not been well considered in the reliability design of the mechanical part and contributed to the theory and method of improving the safety and reliability operation of the mechanical system. more...
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- 2014
159. Electrochemical CO2 Reduction with Atomic Iron‐Dispersed on Nitrogen‐Doped Graphene.
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Zhang, Chenhao, Yang, Shize, Wu, Jingjie, Liu, Mingjie, Yazdi, Sadegh, Ren, Muqing, Sha, Junwei, Zhong, Jun, Nie, Kaiqi, Jalilov, Almaz S., Li, Zhenyuan, Li, Huaming, Yakobson, Boris I., Wu, Qin, Ringe, Emilie, Xu, Hui, Ajayan, Pulickel M., and Tour, James M. more...
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ELECTROCHEMISTRY ,CARBON monoxide ,NITROGEN ,GRAPHENE ,DOPING agents (Chemistry) ,CHEMICAL reduction - Abstract
Abstract: Electrochemical reduction of CO
2 provides an opportunity to reach a carbon‐neutral energy recycling regime, in which CO2 emissions from fuel use are collected and converted back to fuels. The reduction of CO2 to CO is the first step toward the synthesis of more complex carbon‐based fuels and chemicals. Therefore, understanding this step is crucial for the development of high‐performance electrocatalyst for CO2 conversion to higher order products such as hydrocarbons. Here, atomic iron dispersed on nitrogen‐doped graphene (Fe/NG) is synthesized as an efficient electrocatalyst for CO2 reduction to CO. Fe/NG has a low reduction overpotential with high Faradic efficiency up to 80%. The existence of nitrogen‐confined atomic Fe moieties on the nitrogen‐doped graphene layer is confirmed by aberration‐corrected high‐angle annular dark‐field scanning transmission electron microscopy and X‐ray absorption fine structure analysis. The Fe/NG catalysts provide an ideal platform for comparative studies of the effect of the catalytic center on the electrocatalytic performance. The CO2 reduction reaction mechanism on atomic Fe surrounded by four N atoms (Fe–N4 ) embedded in nitrogen‐doped graphene is further investigated through density functional theory calculations, revealing a possible promotional effect of nitrogen doping on graphene. [ABSTRACT FROM AUTHOR] more...- Published
- 2018
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160. Comparison of Long-Term Outcomes between Peritoneal Dialysis Patients with Diabetes as a Primary Renal Disease or as a Comorbid Condition
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Lei, Yutian, primary, Xiong, Yifan, additional, Zhang, Lin, additional, Yan, Hao, additional, Li, Zhenyuan, additional, Cao, Liou, additional, Huang, Jiaying, additional, Gu, Aiping, additional, Ni, Zhaohui, additional, Qian, Jiaqi, additional, and Fang, Wei, additional more...
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- 2015
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161. Feasibility of Urgent-Start Peritoneal Dialysis in Older Patients with End-Stage Renal Disease: A Single-Center Experience
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Jin, Haijiao, Ni, Zhaohui, Mou, Shan, Lu, Renhua, Fang, Wei, Huang, Jiaying, Hu, Chunhua, Zhang, Haifen, Yan, Hao, Li, Zhenyuan, and Yu, Zanzhe
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Background Patients with end-stage renal disease (ESRD) frequently require urgent-start dialysis. Recent evidence suggests that peritoneal dialysis (PD) might be a feasible alternative to hemodialysis (HD) in these patients, including in older patients.Methods This retrospective study enrolled patients aged > 65 years with ESRD who underwent urgent dialysis without functional vascular access or PD catheter at a single center, from January 2011 to December 2014. Patients were grouped based on their dialysis modality (PD or HD). Patients unable to tolerate PD catheter insertion or wait for PD were excluded. Each patient was followed for at least 30 days after catheter insertion. Short-term (30-day) dialysis-related complications and patient survival were compared between the 2 groups.Results A total of 94 patients were enrolled, including 53 (56.4%) who underwent PD. The incidence of dialysis-related complications during the first 30 days was significantly lower in PD compared with HD patients (3 [5.7%] vs 10 [24.4%], p= 0.009). Logistic regression identified urgent-start HD as an independent risk factor for dialysis-related complications compared with urgent-start PD (odds ratio 4.760 [1.183 – 19.147], p= 0.028). The 6-, 12-, 24-, and 36-month survival rates in the PD and HD groups were 92.3% vs 94.6%, 82.4% vs 81.3%, 75.7% vs 74.2%, and 69.5% vs 60.6%, respectively, with no significant differences between the groups (log-rank = 0.011, p= 0.915).Conclusion Urgent-start PD was associated with fewer short-term dialysis-related complications and similar survival to urgent-start HD in older patients with ESRD. Peritoneal dialysis may thus be a safe and effective dialysis modality for older ESRD patients requiring urgent dialysis. more...
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- 2018
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162. Polarization Microscopy Study on Piezo-Optical Effect of Polymer Dispersed Liquid Crystal Films
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Li Zhenyuan, 黎振远, primary, Fan Zhixin, 范志新, additional, Li Jinwei, 李金炜, additional, Zhao Yongfang, 赵永芳, additional, and Sun Yubao, 孙玉宝, additional
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- 2011
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163. Polarization Microscopy Study on Piezo-Optical Effect of Polymer Dispersed Liquid Crystal Films
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赵永芳 Zhao Yongfang, 范志新 Fan Zhixin, 孙玉宝 Sun Yubao, 黎振远 Li Zhenyuan, and 李金炜 Li Jinwei
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chemistry.chemical_classification ,Materials science ,Optics ,chemistry ,Liquid crystal ,business.industry ,Polarization Microscopy ,Optoelectronics ,Polymer ,business ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Published
- 2011
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164. Query interface schema extracting from deep web using ontology.
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Sun, Yong, Wang, Shang, Li, Zhenyuan, Liu, Chang, Peng, Tao, and Qiu, Yuhang
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- 2022
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165. Recent advances in developing mixed matrix membranes based on covalent organic frameworks.
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Wang, Shunli, Wei, Xin, Li, Zhenyuan, Liu, Yiqun, Wang, Haitao, Zou, Lei, Lu, Dongwei, Hassan Akhtar, Faheem, Wang, Xinbo, Wu, Changjiang, and Luo, Shuangjiang
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SEPARATION of gases , *ORGANIC bases , *GAS separation membranes , *POROSITY , *MATERIALS science - Abstract
[Display omitted] • The mixed matrix membranes based on COFs for separation are systematically reviewed. • The development of COF fillers and structure–property relationships are highlighted. • The challenges involved in COF-based mixed matrix membranes are presented. Mixed matrix membranes (MMMs) combining the virtues of porous fillers with polymeric matrices have been widely investigated due to their potential to overcome the permeability-selectivity trade-off. However, the compatibility issues at the organic/inorganic interface have barred their large-scale applications. With the rapid advances in chemistry and material science, recent research has turned to covalent organic frameworks (COFs) with regular pore structure, high specific surface area, and good compatibility with polymer matrix as promising fillers to improve the separation performance of MMMs. This review summarizes the research progresses on COF-based MMMs for gas and liquid separations, including various COF linkages, properties of COFs, and the selection principle of COF materials for target applications. Moreover, according to the geometric symmetry of building blocks and the different dimensions of the covalently connected frameworks, COFs fillers are categorized into two types: (1) 2D COFs; (2) 3D COFs. The applications of COF-based MMMs are subsequently reviewed, focusing on the effects of COF fillers on the performance of mixed matrix membranes in gas and liquid separations. Finally, the prospects and challenges of COF-based MMMs in industrial applications are briefly summarized to guide the future design of high-performance COF-based MMMs. [ABSTRACT FROM AUTHOR] more...
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- 2022
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166. The effect of physical exercise therapy on autism spectrum disorder:a systematic review and meta-analysis.
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Wu, Yifan, Ding, Lu, Zhang, Qiao, Dong, Yu, Tao, Chenyang, Li, Zhenyuan, Li, Zhaowei, and Lu, Liming
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AUTISM spectrum disorders , *EXERCISE physiology , *EXECUTIVE function , *EXERCISE therapy , *PHYSICAL therapy - Abstract
• The meta-analysis we conducted was for RCTs only. • we searched and included English and Chinese databases up to July 31, 2023. • we conducted a comprehensive analysis of the effects of exercise on autism. • we summarized the preliminary evidence on the dose of exercise for the treatment of autism. • we found limitations in the improvement of executive function in autism. Physical Exercise Therapy (PET) is increasingly applied in the treatment of Autism Spectrum Disorders (ASD), yet the empirical evidence supporting its efficacy remains ambiguous. This systematic review and meta-analysis aimed to investigate the effectiveness of PET for individuals with ASD, providing evidence-based support for clinical and scientific research. We systematically searched four international databases (Medline via PubMed, Embase, Cochrane Libraries, and Web of Science) and three Chinese databases (CNKI, Wanfang, and VIP Libraries) up to July 31, 2023. The search was conducted in both English and Chinese for original research articles employing randomized-controlled-trial (RCT) designs to study PET's effects on individuals diagnosed with ASD according to DSM or other established criteria. Co-primary outcomes focused on the overall severity of autism, while secondary outcomes included measures of stereotyped behaviors, social deficits, social skills, and executive functioning. Data from the included studies were synthesized and analyzed using RevMan 5.4. This systematic review is registered with PROSPERO (CRD42023443951). A total of 28 RCTs comprising 1081 participants were analyzed. Of these, only three studies met high-quality standards. Compared to control groups, PET showed improvement in at least one core symptom of autism, including Motor Performance (SMD=1.72, 95%CI[1.01, 2.44], I2=90%), Restricted Repetitive Behaviors (SMD=-0.81, 95%CI[-1.00, -0.62], I2=0%), Social Dysfunction (SMD=-0.76, 95%CI[-1.06, -0.46], I2=47%). PET may offer benefits in reducing the overall severity and associated symptoms in individuals with ASD. However, given the high overall risk of bias in the included studies, these findings should be interpreted with caution. [ABSTRACT FROM AUTHOR] more...
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- 2024
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167. SCD1 promotes the stemness of gastric cancer stem cells by inhibiting ferroptosis through the SQLE/cholesterol/mTOR signalling pathway.
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Mao, Xinyuan, Wang, Lingzhi, Chen, Zhian, Huang, Huilin, Chen, Jialin, Su, Jin, Li, Zhenhao, Shen, Guodong, Ren, Yingxin, Li, Zhenyuan, Wang, Weisheng, Ou, Jinzhou, Guo, Weihong, and Hu, Yanfeng
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Cancer stem cells (CSCs) play a substantial role in cancer onset and recurrence. Anomalous iron and lipid metabolism have been documented in CSCs, suggesting that ferroptosis, a recently discovered form of regulated cell death characterised by lipid peroxidation, could potentially exert a significant influence on CSCs. However, the precise role of ferroptosis in gastric cancer stem cells (GCSCs) remains unknown. To address this gap, we screened ferroptosis-related genes in GCSCs using The Cancer Genome Atlas and corroborated our findings through quantitative polymerase chain reaction and western blotting. These results indicate that stearoyl-CoA desaturase (SCD1) is a key player in the regulation of ferroptosis in GCSCs. This study provides evidence that SCD1 positively regulates the transcription of squalene epoxidase (SQLE) by eliminating transcriptional inhibition of P53. This mechanism increases the cholesterol content and the elevated cholesterol regulated by SCD1 inhibits ferroptosis via the mTOR signalling pathway. Furthermore, our in vivo studies showed that SCD1 knockdown or regulation of cholesterol intake affects the stemness of GCSCs and their sensitivity to ferroptosis inducers. Thus, targeting the SCD1/squalene epoxidase/cholesterol signalling axis in conjunction with ferroptosis inducers may represent a promising therapeutic approach for the treatment of gastric cancer based on GCSCs. • SCD1 can play a role in the regulation of ferroptosis by regulating cholesterol metabolism. • Gastric cancer stem cells exhibit aberrant cholesterol metabolism. • The elevated cholesterol levels induced by SCD1 facilitate the resistance of gastric cancer stem cells against ferroptosis via the mTOR signaling pathway. [ABSTRACT FROM AUTHOR] more...
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- 2024
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168. Icariside I enhances the effects of immunotherapy in gastrointestinal cancer via targeting TRPV4 and upregulating the cGAS-STING-IFN-I pathway.
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Li, Zhenhao, Chen, Zhian, Wang, Yutong, Li, Zhenyuan, Huang, Huilin, Shen, Guodong, Ren, Yingxin, Mao, Xinyuan, Wang, Weisheng, Ou, Jinzhou, Lin, Liwei, Zhou, Jinlin, Guo, Weihong, Li, Guoxin, Lu, Yu-Jing, and Hu, Yanfeng more...
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GASTROINTESTINAL cancer , *TRPV cation channels , *IMMUNE checkpoint proteins , *IMMUNOTHERAPY , *MITOCHONDRIAL DNA - Abstract
Gastrointestinal cancer is among the most common cancers worldwide. Immune checkpoint inhibitor-based cancer immunotherapy has become an innovative approach in cancer treatment; however, its efficacy in gastrointestinal cancer is limited by the absence of infiltration of immune cells within the tumor microenvironment. Therefore, it is therefore urgent to develop a novel therapeutic drug to enhance immunotherapy. In this study, we describe a previously unreported potentiating effect of Icariside I (ICA I, GH01), the main bioactive compound isolated from the Epimedium species, on anti-tumor immune responses. Mechanistically, molecular docking and SPR assay result show that ICA I binding with TRPV4. ICA I induced intracellular Ca2+ increasing and mitochondrial DNA release by targeting TRPV4, which triggered cytosolic ox-mitoDNA release. Importantly, these intracellular ox-mitoDNA fragments were taken up by immune cells in the tumor microenvironment, which amplified the immune response. Moreover, our study shows the remarkable efficacy of sequential administration of ICA I and anti-α-PD-1 mAb in advanced tumors and provides a strong scientific rationale for recommending such a combination therapy for clinical trials. ICA I enhanced the anti-tumor effects with PD-1 inhibitors by regulating the TRPV4/Ca2+/Ox-mitoDNA/cGAS/STING axis. We expect that these findings will be translated into clinical therapies, which will benefit more patients with cancer in the near future. [Display omitted] • ICA I was efficiently extracted by computer-aided protein design strategy. • ICA I induces mitochondrial dysfunction by binding to TRPV4 channel and increasing intracellular Ca2+ concentration • ICA I enhanced anti-tumor effects of PD-1 inhibitors by modulating the TRPV4/Ca2+/Ox-mitoDNA/cGAS/STING axis [ABSTRACT FROM AUTHOR] more...
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- 2024
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169. FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
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Wang, Lingzhi, Mao, Xinyuan, Yu, Xiang, Su, Jin, Li, Zhenyuan, Chen, Zhian, Ren, Yingxin, Huang, Huilin, Wang, Weisheng, Zhao, Cuiyin, and Hu, Yanfeng
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STOMACH cancer , *METABOLIC reprogramming , *CALCIUM ions , *ACTIVATED protein C resistance , *NOTCH proteins , *PEPTIDE receptors - Abstract
Aerobic glycolysis accelerates tumor proliferation and progression, and inhibitors or drugs targeting abnormal cancer metabolism have been developing. Cancer stem-like cells (CSCs) significantly contribute to tumor initiation, metastasis, therapy resistance, and recurrence. Formyl peptide receptor 3 (FPR3), a member of FPR family, involves in inflammation, tissue repair, and angiogenesis. However, studies in exploring the regulatory mechanisms of aerobic glycolysis and CSCs by FPR3 in gastric cancer (GC) remain unknown. Here, we demonstrated that overexpressed FPR3 suppressed glycolytic capacity and stemness of tumor cells, then inhibited GC cells proliferation. Mechanistically, FPR3 impeded cytoplasmic calcium ion flux and hindered nuclear factor of activated T cells 1 (NFATc1) nuclear translocation, leading to the transcriptional inactivation of NFATc1-binding neurogenic locus notch homolog protein 3 (NOTCH3) promoter, subsequently obstructing NOTCH3 expression and the AKT/mTORC1 signaling pathway, and ultimately downregulating glycolysis. Additionally, NFATc1 directly binds to the sex determining region Y-box 2 (SOX2) promoter and modifies stemness in GC. In conclusion, our work illustrated that FPR3 played a negative role in GC progression by modulating NFATc1-mediated glycolysis and stemness in a calcium-dependent manner, providing potential insights into cancer therapy. • FPR3 served as a tumor suppressor in gastric cancer. • FPR3 reprograms glycolysis and stemness in GC. • FPR3 influences cytoplasmic calcium ion and downstream NFATc1 activity. • NFATc1 bound to NOTCH3 promoter to modulate AKT/mTORC1 pathway. • FPR3 interferes with cancer stemness via NOTCH3 and SOX2. [ABSTRACT FROM AUTHOR] more...
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- 2024
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170. Mitigation mechanism of resveratrol on thermally induced trans-α-linolenic acid of trilinolenin.
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Liang, Manzhu, Li, Tian, Qu, Yang, Qin, Jingjing, Li, Zhenyuan, Huang, Xuegang, Zhang, Qiaozhen, Zhang, Yu, Guo, Qin, and Wang, Qiang
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TRANS fatty acids , *EDIBLE fats & oils , *RESVERATROL , *DENSITY functional theory , *STERIC hindrance - Abstract
Investigations in the control of the thermal isomerization of trans fatty acids (TFAs) in edible oils are of great significance in effectively improving the safety of edible oil. The mitigation mechanism of resveratrol (Res) on thermally induced trans -α-linolenic acids (TALAs) of trilinolenin was delved by gas chromatography and density functional theory. The results revealed that the mitigative rate of Res on TALAs in trilinolenin increased with the heating temperature and time, and C18-3:9 c ,12 c ,15 t (3.82 ∼ 13.90%) > C18-3:9 t ,12 c ,15 c (3.47 ∼ 11.50%) > C18-3:9 c ,12 t ,15 c (4.22 ∼ 4.72%). After heating at 180 °C and 200 °C for 4 h and 8 h without oxygen, the mitigation of TALAs by Res was mainly exerted by the hydrogen extraction and proton transfer isomerism mechanism. Both mitigation mechanisms were that Res firstly bound to the Ln allyl position to increase molecular steric hindrance, thereby preventing the bond rotation and proton transfer to inhibit the formation of TALAs; Res was preferentially bound to the di -allyl sites (Ln-11 site > Ln-14 site), followed by the mono -allyl sites (Ln-17 site > Ln-8 site). The study provides a theoretical foundation for the precise control of TALAs in edible oil systems. [Display omitted] • Resveratrol (Res) can mitigate trans -α-linolenic acid formed from heated trilinolenin. • The mitigation rate of Res was C18-3:9 c ,12 c ,15 t > C18-3:9 t ,12 c ,15 c > C18-3:9 c ,12 t ,15 c. • The mitigation acted by Res via hydrogen abstraction and proton transfer mechanism. • The binding sites of Res mitigating trans -α-linolenic acid are mono - or di- allyl sites. [ABSTRACT FROM AUTHOR] more...
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- 2023
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171. Paxlovid for hospitalized COVID-19 patients with chronic kidney disease.
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Cai, Hong, Yan, Jiayi, Liu, Shang, Li, Ping, Ding, Li, Zhan, Yaping, Lu, Jiayue, Li, Zhenyuan, Sun, Yiwen, Zhu, Mingli, Gao, Yuan, Gong, Xingrong, Ban, Haiqun, Gu, Leyi, Zhou, Weibin, Wang, Jieying, and Mou, Shan more...
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COVID-19 treatment , *COVID-19 , *CHRONIC kidney failure , *CHRONICALLY ill , *HOSPITAL patients - Abstract
COVID-19 causes significant mortality during the recent pandemic. Data regarding the effectiveness of Paxlovid on COVID-19 patients with chronic kidney disease (CKD, eGFR <90 ml/min) are limited. A retrospective cohort study was performed on the clinical data of the hospitalized adult patients with confirmed COVID-19 infection collected at Renji Hospital from April 7, 2022 to June 21, 2022. The association of Paxlovid treatment with early (within 5 days post diagnosis) or late (5 days or later post diagnosis) initiation time with clinical outcomes was assessed by Cox proportional hazards regression model with time-dependent covariates. 1279 of 2387 enrollees were included in the study. Patients with early initiation of Paxlovid had a lower all-cause death rate compared to those with late initiation or without Paxlovid treatment (P = 0.046). For the CKD patients with Charlson comorbidity index (CCI) > 7, the early initiation of Paxlovid was associated with a lower all-cause death rate compared to the later initiation or the lack of Paxlovid treatment (P = 0.041). Cox regression analyses revealed that eGFR (HR 4.21 [95%, CI 1.62–10.99]), Paxlovid treatment (0.32 [0.13–0.77]), CCI (4.32 [1.64–11.40]), ICU admission (2.65 [1.09–6.49]), hsCRP (3.88 [1.46–7.80]), chronic liver disease (4.02 [1.09–14.85]) were the independent risk factors for all-cause death for CKD patients after adjusting for demographics and biochemical indexes. All-cause death, invasive ventilation, and ICU admission were all significantly lowered by an early initiation of Paxlovid treatment in COVID-19 patients with severe CKD. • The Viral load decreased faster in patients with eGFR<90 ml/min who received Paxlovid treatment≤5 days. • All-cause death was lower by taking Paxlovid in severe COVID-19 patients with chronic kidney disease. • eGFR, Paxlovid treatment were the independent risk factors for all-cause death in patients with eGFR<90 ml/min. [ABSTRACT FROM AUTHOR] more...
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- 2023
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172. Nonlinear dynamic model for linear guideway with crowning subjected to external load in five directions.
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Xu, Mengtao, Zhang, Hongzhuang, Liu, Zhendong, Li, Changyou, Li, Zhenyuan, Liu, Haiyang, and Zhang, Yimin
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DYNAMIC models , *COORDINATE transformations , *BLAST effect , *COMPUTER simulation , *EQUATIONS of motion - Abstract
• Time-dependent dynamic model of linear guideway with crowning is established. • The idea of coordinate transformation is used to propose the five DOF model. • The possible contact states of each ball are considered due to load distribution. • The ball passage vibration in five directions is predicted. The motion accuracy of linear guideway is adversely affected by ball passage vibration (BPV) when rolling balls within carriage move in a loop. Reduced vibration amplitude can be realized by a carriage with crowning design by now. However, few dynamic models are availability for the BPV analysis when linear guideway is subjected to actual external load in five directions. In this paper, a nonlinear dynamic model is proposed to investigate the periodic micro fluctuation of linear guideway with crowning subjected to load in five directions. The idea of coordinate transformation is adopted for the easier derivations of time-dependent and piecewise restoring force function. The different contact states of each ball are described in detail due to load distribution. The numerical simulation is employed to deal with equation of motion and discuss the effects of ball grouping, external load, preload and carriage speed. Experiment is also conducted for the verification of proposed model. The analytical model developed here is promising to clarify the mechanism of BPV from a dynamic perspective and serve the walking parallelism accuracy monitoring of linear guideway. [ABSTRACT FROM AUTHOR] more...
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- 2023
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173. Adaptive immune dysfunction in patients with COVID-19 and impaired kidney function during the omicron surge.
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Yan, Jiayi, Wang, Jieying, Ding, Li, Liu, Shang, Zhan, Yaping, Lu, Jiayue, Li, Zhenyuan, Gu, Leyi, Li, Ping, Zhu, Mingli, Gao, Yuan, Gong, XingRong, Ban, Haiqun, Cai, Hong, and Mou, Shan
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COVID-19 , *KIDNEY physiology , *SARS-CoV-2 Omicron variant , *LYMPHOCYTE subsets , *PROPENSITY score matching - Abstract
Little is known about the characteristics of lymphocyte subsets and the association with patient outcomes in COVID-19 with and without impaired kidney function. Lymphocyte subsets were compared in COVID-19 patients with or without kidney dysfunction. The primary outcome was a composite of all-cause mortality or intensive care unit admission. Secondary outcomes included duration of viral shedding, length of hospital stay, and acute kidney injury. Lymphocyte subset cell counts demonstrated the lowest in patients with severe/critical COVID-19 and kidney dysfunction. Among all lymphocyte subset parameters, Th cell count was the most significant indicator for outcomes. ROC of the combined model of Th cell count and eGFR presented better predictive value than that of the other parameters. Th cell count <394.5 cells/μl and eGFR <87.5 ml/min/1·73m2 were independently associated with poor outcomes. The propensity score matching analysis revealed consistent results. Reduced Th cell count and eGFR may be applied as promising predictive indicators for identifying COVID-19 patients with high risk and poor outcomes. [ABSTRACT FROM AUTHOR] more...
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- 2023
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174. Cancer cell membrane biomimetic mesoporous silica nanotheranostics for enhanced Ferroptosis-mediated immuogenic cell death on Gastric cancer.
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Guo, Weihong, Chen, Zhian, Li, Zhenhao, Huang, Huilin, Ren, Yingxin, Li, Zhenyuan, Zhao, Bingxia, Li, Guoxin, and Hu, Yanfeng
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CELL death , *STOMACH cancer , *NICOTINAMIDE adenine dinucleotide phosphate , *CANCER cells , *MESOPOROUS silica , *CYTOTOXIC T cells , *NUCLEAR DNA , *SILICA nanoparticles - Abstract
[Display omitted] • Biomimetic CMnMPt exhibited homologous targeting function for gastric cancer. • Upon exposure to GSH, MnMPt was biodegraded, resulting in Mn2+ and Pt(II) release. • Pt(II) enhance Mn2+-mediated Fenton reaction, contributing to LPO generation. • The accumulation of LPO and consumption of GSH caused by CMnMPt, lead to ferroptosis. • CMnMPt activates anti-tumor immunity via triggering ferroptosis-mediated ICD effect. Selective induction of ferroptosis of cancer cells would be a promising approach to trigger immunogenic cell death (ICD) and sequentially potentiate immunotherapy. Actually, the efficiency to produce toxic lipid peroxides (LPO) and deplete glutathione (GSH) at the tumor site plays a key role in inducing ferroptosis. Herein, a cancer targeted cascade nanosystem (CCM@Mn@MSN-Pt(IV), CMnMPt) was constructed for synergistic chemo-dynamic and chemotherapy by conjugating Mn ions-doped mesoporous silica nanoparticles (Mn@MSN) and cisplatin prodrug (Pt(IV)), with cancer cell membrane cloaking. Owing to the bio-mimetic surface functionalization, the immune escape and homologous targeting behaviors of CMnMPt would dramatically enhance its cancer targeting and retention abilities. Once internalized by cancer cells, intracellular GSH would be depleted attributed to the bio-degradation of Mn@MSN and reduced of Pt(IV), resulting in Mn2+ release and cisplatin transform (from Pt(IV) to Pt(II)). Subsequently, generated Pt(II)) could damage nuclear DNA, and further activate nicotinamide adenine dinucleotide phosphate oxidases (NOXs) to enhance downstream H 2 O 2 levels. Additionally, Mn2+ ions could catalyze H 2 O 2 into highly reactive hydroxyl radical (OH), which results in a further increase in LPO content. In summary, CMnMPt could induce ferroptosis-mediated ICD, and recruit cytotoxic T lymphocytes cells, offering potential clinical applications to facilitate anti-tumor immunotherapy. [ABSTRACT FROM AUTHOR] more...
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- 2023
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175. Nonlinear dynamic analysis of ball screw feed system considering assembly error under harmonic excitation.
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Liu, Zhendong, Xu, Mengtao, Zhang, Hongzhuang, Miao, HuiHui, Li, Zhenyuan, Li, Changyou, and Zhang, Yimin
- Subjects
- *
NONLINEAR analysis , *NUMERICAL solutions to equations , *CENTROID , *SCREWS , *EXCITATION (Physiology) , *BIFURCATION diagrams - Abstract
• A dynamic model is proposed for the feed system and verified by an experiment. • The deflection angle caused by assembly error is considered. • The system parameters are investigated with different control parameters. In this study, a multi-degree-of-freedom dynamic model is developed to investigate the nonlinear dynamic characteristic of the ball screw feed system. The fourth-order Runge–Kutta method is used to obtain the numerical solution of the governing equations. In the proposed dynamic model, the assembly error of the system is considered as the deflection angle around the geometric center of the screw shaft. The motion of the system at each point is illustrated by displacement waveform, spectrum, phase diagram and Poincaré section. The influence of excitation amplitude and assembly error is discussed with excitation amplitude, deflection angle, and excitation frequency as control parameter in the bifurcation diagram and 3-D frequency spectrum. The results show that the assembly error has impacts on dynamic response, and the region of chaotic motion near resonance frequency broadens. Beyond that, an experiment is setup, and acceleration signals with different excitation frequencies and different excitation amplitudes are collected to validate the proposed model. [ABSTRACT FROM AUTHOR] more...
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- 2021
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176. Tunable broadband terahertz absorber based on graphene metamaterials and VO2.
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Zhou, Runhua, Jiang, Tingting, Peng, Zhen, Li, Zhenyuan, Zhang, Min, Wang, Shixing, Li, Ling, Liang, Huawei, Ruan, Shuangchen, and Su, Hong
- Subjects
- *
TERAHERTZ materials , *PHASE change materials , *GRAPHENE , *OXYGEN consumption , *METAMATERIALS , *VANADIUM dioxide - Abstract
A tunable broadband terahertz (THz) absorber is designed in this paper, which is composed of graphene, silica medium and phase change material Vanadium dioxide (VO 2). By simultaneously changing the fermi level of graphene and conductivity of VO 2 , the dual-controlled absorber can be realized. The results show that the full width at half maximum of the absorption spectrum is 1.03 THz, the bandwidth with the absorptance above 90% is 0.65 THz, and the absorptance is close to 100% at 1.2 THz. Moreover, the absorptance, transmittance and reflectance of the absorber can be dynamically adjusted from 0 to 99%, 0–65%, and 0–74%, respectively. The large tunability allows the proposed absorber to be used as THz tunable filters, sensors, switches and modulators. • A broadband metamaterial absorber has been proposed based on the patterned graphene resonators. • Dual control and tunability is realized based on graphene array and phase change material vanadium dioxide. • The proposed structure can be dynamically tuned to act as an absorber or reflector. • The structure can be made to work in transmission or absorption mode by changing the conductivity of vanadium dioxide. [ABSTRACT FROM AUTHOR] more...
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- 2021
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177. The fatigue performance evaluation of additively manufactured 304L austenitic stainless steels.
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Zhang, Hongzhuang, Li, Changyou, Xu, Mengtao, Dai, Weibing, Kumar, Punit, Liu, Zhendong, Li, Zhenyuan, and Zhang, Yimin
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- *
AUSTENITIC stainless steel , *FIELD emission electron microscopes , *ACOUSTIC emission - Abstract
This study carried out the fatigue tests of selective laser melting (SLM) 304L austenitic stainless steel (SS) made by different scanning speeds. The purpose is to deeply understand the microstructure, fatigue failure process and fatigue failure mechanism of SLMed 304L SS. For this purpose, the microstructure, surface roughness and porosity were tested by field emission scanning electron microscope (FESEM) and electron backscatter diffraction (EBSD), while the residual stress was obtained by μ-X360 residual stress analyzer. In addition, the fatigue failure process of SLMed 304L SS was in-situ monitored through acoustic emission (AE) technique and thermal imager. The results show that SLMed 304L SS has excellent fatigue performance. The 'critical' value is defined to distinguish the critical influence of surface roughness and porosity. In addition, the temperature rise caused by the stored energy deriving from the active dislocation motions is affected by the loading direction and scanning direction by regulating the dislocation motions during fatigue testing. [ABSTRACT FROM AUTHOR] more...
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- 2021
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178. Optimal biochar amendment rate reduced the yield-scaled N2O emissions from Ultisols in an intensive vegetable field in South China.
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Li, Bo, Huang, Weihao, Elsgaard, Lars, Yang, Bo, Li, Zhenyuan, Yang, Haofeng, and Lu, Ying
- Abstract
Nitrous oxide (N 2 O) emissions, vegetable yields, and soil microbial properties were studied in response to different rates of rice-straw biochar applied to an intensive vegetable soil (Ultisol) in South China. The study was conducted over a one-year period as a block-designed field experiment (n = 3) with two successive crops and five harvests in total. Biochar was applied at rates of 0, 10, 20, 30 and 40 Mg ha−1 and splits of nitrogen (N) fertilizer were added in the form of urea (1010 kg N in total). References without biochar and N fertilization were included. Biochar significantly decreased the cumulative annual N 2 O emissions by 34–67%, which concurred with decreased denitrification enzyme activity and increased nosZ gene abundance in the vegetable soil. The absolute N 2 O mitigation increased with increasing flux rates, which were positively correlated to soil temperature and water-filled pore space. Conversely, weak increases of N 2 O emissions were recurrently induced by biochar when the soil temperature was lower than 20 °C and the absolute fluxes were low. A significant 17–29% increase in vegetable yield was induced by biochar, which also ameliorated soil fertility by increasing the soil carbon content and the cation exchange capacity. Overall, biochar significantly decreased the yield-scaled N 2 O emissions by 44–71% with the lowest yield-scaled N 2 O emissions for the intermediate biochar application rate of 20 Mg ha−1. Higher biochar application rates failed to further decrease the yield-scaled N 2 O emissions, but rather caused weak increases. Based on the present results, a biochar application rate of 20 Mg ha−1 combined with N fertilization seemed to be recommendable to achieve highest vegetable yield with lowest N 2 O emissions in intensive vegetable production in South China. Unlabelled Image • Biochar considerably mitigated N 2 O emissions along with the increase of denitrifiers in vegetable soil. • N 2 O reduction induced by biochar enhanced with the increasing of soil temperature (>20 °C) and WFPS • Biochar at 20 Mg ha−1 can be optimal biochar rate in mitigating yield-scaled N 2 O emissions from Ultisols. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
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179. Serum angiopoietin-2/angiopoietin-1 ratio is associated with cardiovascular and all-cause mortality in peritoneal dialysis patients: a prospective cohort study.
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Li H, Song Q, Su X, Shen Y, Yan H, Yu Z, Li Z, Yuan J, Huang J, Ni Z, Gu L, and Fang W
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- Humans, Male, Female, Middle Aged, Prospective Studies, Aged, Adult, Kidney Failure, Chronic therapy, Kidney Failure, Chronic blood, Kidney Failure, Chronic mortality, C-Reactive Protein analysis, Biomarkers blood, Cause of Death, Risk Factors, Proportional Hazards Models, Angiopoietin-2 blood, Peritoneal Dialysis mortality, Cardiovascular Diseases mortality, Cardiovascular Diseases blood, Angiopoietin-1 blood
- Abstract
Introduction: Our objective was to examine the factors associated with the serum angiopoietin-2/angiopoietin-1 (Angpt-2/Angpt-1) ratio in peritoneal dialysis (PD) patients and to investigate the association between Angpt-2/Angpt-1 ratio and cardiovascular and all-cause mortality., Methods: Patients on PD who were prevalent between January 2014 and April 2015 in the center of Renji Hospital were enrolled. At the time of enrollment, serum and dialysate samples were collected to detect biochemical parameters, serum angiopoietin-2 and angiopoietin-1 levels. Patients were dichotomized into two groups according to a median of Angpt-2/Angpt-1 ratio and followed up prospectively until the end of the study., Results: A total of 325 patients were enrolled, including 168 males (51.7%) with a mean age of 56.9 ± 14.2 years and a median PD duration of 32.4 (9.8-55.9) months. Multiple linear regression showed pulse pressure (β = 0.206, p < .001) and high-sensitivity C-reactive protein (hs-CRP) (β = 0.149, p = .011) were positively correlated with serum Angpt-2/Angpt-1 ratio, while residual renal function (RRF) (β= -0.219, p < .001) was negatively correlated with serum Angpt-2/Angpt-1 ratio. Multivariate Cox regression analysis showed the high serum Angpt-2/Angpt-1 ratio was an independent predictor of cardiovascular mortality (hazard ratio (HR)=2.467, 95% confidence interval (CI) 1.243-4.895, p = .010) and all-cause mortality (HR = 1.486, 95%CI 1.038-2.127, p = .031). In further subgroup analysis by gender, a significant association was shown in high Angpt-2/Angpt-1 ratio with all-cause mortality in male ( p < .05), but not in female patients ( p >.05)., Conclusions: High Angpt-2/Angpt-1 ratio is an independent risk factor for cardiovascular and all-cause mortality in PD patients. more...
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- 2024
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180. Protopanaxadiol derivative: A plant origin of novel selective glucocorticoid receptor modulator with anti-inflammatory effect.
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Li Z, Liu T, Xie W, Wang Z, Gong B, Yang M, He Y, Bai X, Liu K, Xie Z, and Fan H
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- Animals, Mice, Humans, RAW 264.7 Cells, Hep G2 Cells, Male, Molecular Docking Simulation, Dextran Sulfate, Mice, Inbred C57BL, Signal Transduction drug effects, Receptors, Glucocorticoid metabolism, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents chemistry, NF-kappa B metabolism, Sapogenins pharmacology, Sapogenins chemistry
- Abstract
Constant efforts have been made to move towards maintaining the positive anti-inflammatory functions of glucocorticoids (GCs) while minimizing side effects. The anti-inflammatory effect of GCs is mainly attributed to the inhibition of major inflammatory pathways such as NF-κB through GR transrepression, while its side effects are mainly mediated by transactivation. Here, we investigated the selective glucocorticoid receptor modulator (SGRM)-like properties of a plant-derived compound. In this study, glucocorticoid receptor (GR)-mediated alleviation of inflammation by SP-8 was investigated by a combination of in vitro, in silico, and in vivo approaches. Molecular docking and cellular thermal shift assay suggested that SP-8 bound stably to the active site of GR via hydrogen bonding and hydrophobic interactions. SP-8 activated GR, induced GR nuclear translocation, and inhibited NF-κB pathway activation. Furthermore, SP-8 did not up-regulate the gene and protein expression of PEPCK and TAT in HepG2 cells, and it did not induce fat deposition like GC and has little effect on bone metabolism. Interestingly, SP-8 upregulated GR protein expression and did not cause GR phosphorylation at Ser211 in RAW264.7 cells. This work proved that SP-8 dissociated characteristics of transrepression and transactivation can be separated. In addition, the in vitro and in vivo anti-inflammatory effects of SP-8 were confirmed in LPS-induced RAW 264.7 cells and in a mouse model of DSS-induced ulcerative colitis, respectively. In conclusion, SP-8 might serve as a potential SGRM and might hold great potential for therapeutic use in inflammatory diseases., Competing Interests: Declaration of competing interest We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. We the undersigned declare that this manuscript is original, has not been published before and is not currently being considered for publication elsewhere. We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us. We understand that the Corresponding Author is the sole contact for the Editorial process. She is responsible for communicating with the other authors about progress, submissions of revisions and final approval of proofs., (Copyright © 2024. Published by Elsevier B.V.) more...
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- 2024
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181. Effects of ethanol addition on the quality and stability of Pickering emulsions: Developing Baijiu-infused ice cream.
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Hei X, Li Z, Liu Z, Li S, Wu C, Ma X, Jiao B, Hu H, Zhu J, Adhikari B, Wang Q, and Shi A
- Subjects
- Particle Size, Viscosity, Rheology, Emulsions chemistry, Ethanol chemistry, Ice Cream
- Abstract
The application of Pickering emulsions in real food systems has attracted increasing research interest. Similarly, the tendency of incorporation of Chinese Baijiu into food products is also increasing. This study aimed to investigate the effects of ethanol addition (3 %-15 %, v/v) on the physicochemical, rheological properties and microstructure of Pickering emulsions. The results showed that ethanol resulted in a decrease in particle size, an increase in the apparent viscosity and in the proportion of adsorbed proteins at the oil-water interface of Pickering emulsions, resulting in an increase in emulsion stability. The results obtained from cryo-scanning electron microscopy showed that the incorporation of Baijiu improve the interaction between the fat globules at the interface, enhanced the film around the bubbles, and led to a reduction in the size and a more uniform distribution of air bubbles in the ice cream. These results indicate that the incorporation of a moderate amount (<15 %, v/v) of ethanol into the Pickering emulsion enhances its stability. Adding Baijiu to the preparation of plant-based ice cream resulted in a mellow texture, fine organization, and suitable hardness. These findings provide valuable information for potential application of ethanol, particularly Baijiu, in Pickering emulsion-based applications, including frozen products., Competing Interests: Declaration of competing interest We that there is no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.) more...
- Published
- 2025
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182. Diffusion-Regulated Interfacial Polymerization of Hierarchically Microporous Polyamide Membranes for Permselective Gas Separations.
- Author
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Sun Y, Yan M, Li Z, Wang L, Chen X, and Luo S
- Abstract
Interfacial polymerization has emerged as a robust method for fabricating task-specific polyamide (PA) membranes. However, the limited microporosity of highly cross-linked PA membranes constrains their effectiveness in gas separation applications. Herein, we introduce an ionic liquid (IL)-regulated interfacial polymerization process to fabricate polyamide nanofilms incorporating kinked tetrakis (4-aminophenyl) methane monomers. In situ ultraviolet-visible spectroscopy demonstrates that the diffusion of 1,3,5-benzenetricarbonyl trichloride (TMC) toward the interface increases with the IL/H
2 O ratio, leading to the formation of a more compact membrane with a higher cross-linking degree. The PA-TAM7/3-60 min membrane exhibits a CO2 permeance of 29.8 GPU and a CO2 /CH4 selectivity of 109, exceeding the 2008 Robeson upper bond. Additionally, the highly cross-linked structure imparts the membranes with notable plasticization resistance. Mixed-gas tests (CO2 /CH4 = 50/50, v/v) reveal that the PA-TAM7/3-60 min membrane experiences only a 2% reduction in CO2 permeance and a 10% decrease in CO2 /CH4 selectivity at a CO2 partial pressure of 300 PSIG, compared to its performance at 30 PSIG. The ease of tuning membrane structure and gas separation performance, along with its excellent plasticization resistance, underscores the potential of these PA membranes for task-specific gas separations. more...- Published
- 2024
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183. Effect of henagliflozin on left ventricular mass index in dialysis patients with HFpEF (HELD-HF): protocol for a multicentre, randomised, double-blind, placebo-controlled trial.
- Author
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Yan H, Wang W, Li Y, Qi Y, Lu R, Zhou Y, Zhang W, Liu S, Pang H, Fang Y, Li Z, Wang J, Jiang M, Pu J, Gu L, and Fang W
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, China, Double-Blind Method, Echocardiography, Heart Ventricles diagnostic imaging, Heart Ventricles physiopathology, Hypertrophy, Left Ventricular etiology, Hypertrophy, Left Ventricular drug therapy, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Sodium-Glucose Transporter 2 Inhibitors therapeutic use, Stroke Volume drug effects, Heart Failure drug therapy, Kidney Failure, Chronic therapy, Kidney Failure, Chronic complications, Renal Dialysis
- Abstract
Introduction: Heart failure with preserved ejection fraction (HFpEF) is a prevalent comorbidity among patients with end-stage kidney disease. Although sodium-glucose cotransporter 2 inhibitors are validated in treating heart failure and ameliorating left ventricular hypertrophy among non-dialysis patients, the effects on dialysis patients are unknown. We previously investigated the pharmacokinetics of henagliflozin in patients undergoing haemodialysis (HD) or peritoneal dialysis (PD) and clarified its safety., Methods and Analysis: This multicentre, randomised, double-blind, placebo-controlled trial is being conducted at three hospitals in Shanghai, China. A target of 108 HD or PD patients with HFpEF are randomly allocated to treatment group (henagliflozin 5 mg/day in addition to standard therapy) or control group (placebo with standard therapy) at a ratio of 1:1. All subjects will be followed up for 24 weeks. The primary outcome is change in echocardiography-measured left ventricular mass index. The secondary interests include changes in left atrial volume index, E/e', e' and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Intergroup comparisons of change in echocardiography-related outcomes from baseline to 24 weeks are based on a linear regression model adjusted for baseline values (analysis of covariance), and repeated measure analysis of variance with Bonferroni adjustment is employed for comparison of change in NT-proBNP. Subgroup analyses of the primary and secondary outcomes are conducted to determine whether the effect of henagliflozin varies according to dialysis modality. The χ
2 method is used to compare the occurrence of adverse events and severe adverse events., Ethics and Dissemination: This trial has been approved by the Ethics Committee of Renji Hospital, School of Medicine, Shanghai Jiao Tong University (LY2023-127-B). All participants provide written informed consent before screening. The results of the trial will be disclosed completely in international peer-reviewed journals. Both positive and negative results will be reported., Trial Registration Number: ChiCTR2300073169., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) more...- Published
- 2024
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184. Precise Helium Sieving from Hydrogen Using Fluorine-Decorated Carbon Hollow Fiber Membranes.
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Wu Q, Liu L, Jiao Y, Li Z, Bai J, Ma X, Luo S, and Zhang S
- Abstract
Separating helium (He) and hydrogen (H
2 ), two gases that are extremely similar in molecular size and condensation properties, presents a formidable challenge in the helium industry. The development of membranes capable of precisely differentiating between these gases is crucial for achieving large-scale, energy-efficient He/H2 separation. However, the limited selectivity of current membranes has hindered their practical application. In this study, we propose a novel approach to overcome this challenge by engineering submicroporous membranes through the fluorination of partially carbonized hollow fibers. We demonstrate that the fluorine substitution on the inner rim of the micropore walls within the carbon hollow fibers enables tunability of the microporous architecture. Furthermore, it enhances interactions between H2 molecules and the micropore walls through the polarization and hydrogen bonding induced by C-F bonds, resulting in simultaneous improvements in both He/H2 diffusivity and solubility selectivities. The fluorinated HFM-550-F-1 min membrane exhibits exceptional mixed-gas separation performance, with a binary mixed-gas He/H2 selectivity of 10.5 and a ternary mixed-gas He/(H2 +CO2 ) selectivity of 20.8, at 40 bar feed pressure and 35 °C, surpassing all previously reported polymer-based gas separation membranes, and remarkable plasticization resistance and long-term continuous stability over 30 days., (© 2024 Wiley-VCH GmbH.) more...- Published
- 2024
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185. Protopanaxadiol prevents cisplatin-induced acute kidney injury by regulating ferroptosis.
- Author
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Song Z, Li Z, Pan T, Liu T, Gong B, Wang Z, Liu K, and Fan H
- Subjects
- Animals, Mice, Humans, Male, Kidney drug effects, Kidney metabolism, Kidney pathology, Disease Models, Animal, Cell Line, Lipid Peroxidation drug effects, Iron metabolism, Antioxidants pharmacology, Cell Survival drug effects, Cisplatin toxicity, Acute Kidney Injury chemically induced, Acute Kidney Injury prevention & control, Acute Kidney Injury metabolism, Ferroptosis drug effects, Sapogenins pharmacology
- Abstract
Objectives: Acute kidney injury (AKI) caused by cisplatin (CDDP) is a complex, critical illness with no effective or specific treatment. The purpose of the study was to assess the protective effect of protopanaxadiol (PPD) on the kidneys in CDDP-induced AKI models and its possible mechanisms., Methods: In vitro, the protection of PPD was assessed in HK-2. KM mice were injected with CDDP to induce AKI models in vivo. The determination of blood urea nitrogen and serum creatinine (SCr) was performed, and pathological changes were examined by histopathological examination. Immunostaining and western blot analyses were used to analyze the expression levels of proteins., Results: PPD can increase the viability of HK-2 cells damaged by CDDP, improve cell morphology, and alleviate the symptoms of AKI in mice. In addition, PPD can down-regulate the protein expression of TRF and up-regulate the protein expression of Ferritin heavy chain, Glutathione peroxidase 4, and ferroptosis suppressor protein 1 reduce the iron content in cells and kidney tissues, and restore the antioxidant defense system., Conclusion: PPD has an inhibitory effect on cisplatin-induced nephrotoxicity, which may be related to the inhibition of ferroptosis by regulating iron metabolism and lipid peroxidation., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) more...
- Published
- 2024
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186. Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway.
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Li Z, Gan H, Ji K, Yang M, Pan T, Meng X, Liu T, Wang Z, Gong B, Liu K, Qi D, and Fan H
- Subjects
- Animals, Mice, Humans, Female, Cell Proliferation drug effects, Adult, Male, Mice, Inbred MRL lpr, Kidney drug effects, Kidney metabolism, Kidney pathology, Lupus Nephritis drug therapy, Lupus Nephritis metabolism, Sapogenins pharmacology, C-Reactive Protein metabolism, MAP Kinase Signaling System drug effects, Serum Amyloid P-Component metabolism
- Abstract
Lupus nephritis (LN) is a kidney disease that occurs after systemic lupus erythematosus (SLE) affects the kidneys. Pentraxin 3 (PTX3) is highly expressed in the serum of patients with LN. Renal PTX3 deposition is directly related to clinical symptoms such as proteinuria and inflammation. The excessive proliferation of mesangial cells (MCs) is one of the representative pathological changes in the progression of LN, which is closely related to its pathogenesis. Protopanaxadiol (PPD) is the main component of ginsenoside metabolism and has not been reported in LN. The aim of this study was to investigate the relationship between PTX3 and mesangial cell proliferation and to evaluate the potential role and mechanism of PPD in improving LN. PTX3 is highly expressed in the kidneys of LN patients and LN mice and is positively correlated with renal pathological indicators, including proteinuria and PCNA. The excessive expression of PTX3 facilitated the proliferation of MCs, facilitated the activation of the MAPK/ERK1/2 signaling pathway, and increased the expression of HIF-1α. Further studies showed that PPD can effectively inhibit the abnormal proliferation of MCs with high expression of PTX3 and significantly improve LN symptoms such as proteinuria in MRL/lpr mice. The mechanism may be related to the inhibition of the PTX3/MAPK/ERK1/2 pathway. In this study, both in vitro, in vivo, and clinical sample results show that PTX3 is involved in the regulation of MCs proliferation and the early occurrence of LN. Natural active compound PPD can improve LN by regulating the PTX3/MAPK/ERK1/2 pathway., (© 2024. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.) more...
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- 2024
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187. Inhibition of STAT3 by S3I-201 suppress peritoneal fibroblast phenotype conversion and alleviate peritoneal fibrosis.
- Author
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Song Q, Li H, Yan H, Yu Z, Li Z, Yuan J, Jiang N, Ni Z, Gu L, and Fang W
- Subjects
- Animals, Humans, Male, Mice, Benzenesulfonates pharmacology, Chlorhexidine analogs & derivatives, Chlorhexidine pharmacology, Disease Models, Animal, Extracellular Matrix metabolism, Interleukin-6 metabolism, Mice, Inbred C57BL, Peritoneal Dialysis adverse effects, Peritoneum pathology, Peritoneum metabolism, Aminosalicylic Acids pharmacology, Fibroblasts metabolism, Fibroblasts drug effects, Fibroblasts pathology, Peritoneal Fibrosis drug therapy, Peritoneal Fibrosis metabolism, Peritoneal Fibrosis pathology, Phenotype, Signal Transduction drug effects, STAT3 Transcription Factor antagonists & inhibitors, STAT3 Transcription Factor metabolism
- Abstract
Peritoneal fibrosis is a common pathological response to long-term peritoneal dialysis (PD) and a major cause for PD discontinuation. Understanding the cellular and molecular mechanisms underlying the induction and progression of peritoneal fibrosis is of great interest. In our study, in vitro study revealed that signal transducer and activator of transcription 3 (STAT3) is a key factor in fibroblast activation and extracellular matrix (ECM) synthesis. Furthermore, STAT3 induced by IL-6 trans-signalling pathway mediate the fibroblasts of the peritoneal stroma contributed to peritoneal fibrosis. Inhibition of STAT3 exerts an antifibrotic effect by attenuating fibroblast activation and ECM production with an in vitro co-culture model. Moreover, STAT3 plays an important role in the peritoneal fibrosis in an animal model of peritoneal fibrosis developed in mice. Blocking STAT3 can reduce the peritoneal morphological changes induced by chlorhexidine gluconate. In conclusion, our findings suggested STAT3 signalling played an important role in peritoneal fibrosis. Therefore, blocking STAT3 might become a potential treatment strategy in peritoneal fibrosis., (© 2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.) more...
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- 2024
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188. Properties and Characterization of Sunflower Seeds from Different Varieties of Edible and Oil Sunflower Seeds.
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Li Z, Xiang F, Huang X, Liang M, Ma S, Gafurov K, Gu F, Guo Q, and Wang Q
- Abstract
Sunflower seeds, oil, and protein powder are rich in nutritional value, but the quality of different varieties of sunflower seeds is quite different, and the comprehensive comparative analysis characteristics of edible and oil sunflower seeds are still unclear. The comprehensive analysis and comparison of the raw material indicators, physicochemical properties, and processing characteristics of four edible and four oil sunflower seed varieties were investigated. The results showed that the engineering properties, texture characteristics, single-cell structure, and oil, protein, and starch granule distribution were different between edible and oil sunflower seeds. The composition of fatty acids and amino acids was different among edible, oil sunflower seeds and different varieties. The oleic acid (18.72~79.30%) and linoleic acid (10.11~51.72%) were the main fatty acids in sunflower seed oil, and in amino acid composition, the highest content was glutamic acid (8.88~11.86 g/100 g), followed by aspartic acid (3.92~4.86 g/100 g) and arginine (4.03~4.80 g/100 g). Sunflower meal proteins were dominated by 11S globulin and 2S albumin, and the secondary structure was dominated by β-folding, with -SH and S-S varying greatly among different varieties. Sunflower meal proteins vary widely in terms of functional properties among different varieties, and specialized quality screening was necessary. This study provided a reference and theoretical support for understanding sunflower seeds to further promote the processing and utilization of sunflower seeds. more...
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- 2024
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189. Manipulating the Properties of Polymer Vitrimer Nanocomposites by Designing Dual Dynamic Covalent Bonds.
- Author
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Li Z, Zhao H, Duan P, Zhang L, and Liu J
- Abstract
Polymer vitrimer is a novel material that contains dynamic covalent bonds (DCBs) allowing it to combine the desirable characteristics of both thermoplastics and thermosets. Similar to the traditional polymer nanocomposites, introducing nanoparticles into polymer vitrimer is also an effective strategy to further enhance its properties. However, a comprehensive understanding of matrix and interfacial bond exchange reactions (BERs) to tailor the properties of polymer vitrimer nanocomposites (PVNs) is still lacking. Herein, we utilized coarse-grained molecular dynamics simulations to investigate model PVNs in which there are two different kinds of DCBs in the vitrimer matrix and at the interface. Our results show that the normalized bond autocorrelation function ( C
sw ) confirms the independence of BERs in the vitrimer matrix and in the interface. By varying the bond swap energy barrier ( Δ E sw ) in the matrix Δ E sw mat or in the interface Δ E sw int , or in both Δ E sw all , a maximum mechanical property is observed at the moderate value of Δ E sw mat , Δ E sw int , or Δ E sw all . Meanwhile, the effect of Δ E sw on the stress relaxation and the bond orientation as a function of the time under a fixed strain is well probed, which both decay more slowly at greater Δ E sw . We simulated the tension-recovery curve to examine the effect of Δ E sw on the hysteresis loss and permanent deformation of PVNs, finding an optimal value to achieve its minimum energy dissipation and maximum recovery ratio. Lastly, we investigated the efficiency of self-healing by building and removing walls from the system. Interestingly, a maximum self-healing efficiency of the stress-strain behavior is observed at moderate Δ E sw . Overall, this study provides valuable insights into the relationship between the structure and properties of PVNs, offering implications for the manipulation of their mechanical properties and enhancement of their self-healing capabilities. more...- Published
- 2024
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190. [Research progress on risk prediction of cardiac arrest].
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Li Z, Fan M, Yan X, Luo J, Xu Y, Su J, and Han X
- Subjects
- Humans, Heart, Incidence, Retrospective Studies, Heart Arrest
- Abstract
Cardiac arrest (CA) is a serious cardiac event, which has a high incidence and low survival rate at home and abroad. In order to predict the risk of CA in advance, a large number of studies have been conducted by relevant researchers. This paper mainly summarizes the characteristics and research status of the existing analysis and prediction of CA from three aspects: the risk prediction factors of CA, the evaluation index of risk prediction of CA and the early warning scoring system of CA. We hope it can help medical staff to understand the current progress in this field, and provide new ways and methods for predicting the risk of CA. more...
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- 2024
- Full Text
- View/download PDF
191. Pharmacokinetics of Henagliflozin in Dialysis Patients with Diabetes.
- Author
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Ding L, Liu S, Yan H, Li Z, Zhou Y, Pang H, Lu R, Zhang W, Che M, Wang L, Wang Q, Fang W, Zhang M, Che X, and Gu L
- Subjects
- Humans, Prospective Studies, Bridged Bicyclo Compounds, Heterocyclic, Area Under Curve, Renal Dialysis, Diabetes Mellitus
- Abstract
Aim: This study aimed to assess the pharmacokinetics of henagliflozin in dialysis patients with diabetes., Methods: In this prospective, randomized, open-label study where 10 hemodialysis and 10 peritoneal dialysis patients with diabetes were randomized in a 1:1:1:1 ratio to oral administration of henagliflozin in doses of 5 and 10 mg/day. The pharmacokinetics of a single dose of henagliflozin on Days 1 and 2, the minimum plasma concentration (C
min ) of the steady state on Day 10, and single hemodialysis clearance of henagliflozin were measured., Results: The mean values of Cmax were 70.2-77.0 ng/mL and 105-143 ng/mL in the 5 mg and 10 mg henagliflozin groups, respectively; the mean values of AUCinf were 777-811 h*ng/mL and 1290-1730 h*ng/mL in the 5 mg and 10 mg henagliflozin groups, respectively. The median Tmax values ranged from 1 to 3 h across the dose range. The mean values of T1/2 of henagliflozin were 14.1-14.5 and 16.2-21.0 h in the 5 mg and 10 mg groups, respectively. The Cmin values of the steady state in dialysis patients taking 5 mg and 10 mg of henagliflozin were 15.0 ± 4.4 ng/mL and 26.8 ± 16.3 ng/mL, respectively, which were 123.8% and 131.0% higher than those in diabetic patients with normal renal function, respectively. Henagliflozin concentration was decreased by 1.1% after hemodialysis treatment. No treatment-related serious adverse events or discontinuations occurred., Conclusions: Henagliflozin at the current recommended dosage may be safe, although it is possible to result in slight accumulation in patients on dialysis., Registration: Chinese Clinical Trial Registry number ChiCTR2200062872. The date of registration: August 22, 2022., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) more...- Published
- 2023
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- View/download PDF
192. HOXA11 promotes lymphatic metastasis of gastric cancer via transcriptional activation of TGFβ1.
- Author
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Li Z, Lu T, Chen Z, Yu X, Wang L, Shen G, Huang H, Li Z, Ren Y, Guo W, and Hu Y
- Abstract
Most gastric cancer (GC) patients with early stage often have no lymph node (LN) metastases, while LN metastases appear in the advanced stage. However, there are some patients who present with early stage LN metastases and no LN metastases in the advanced stage. To explore the deeper molecular mechanisms involved, we collected clinical samples from early and advanced stage GC with and without LN metastases, as well as metastatic lymph nodes. Herein, we identified a key target, HOXA11, that was upregulated in GC tissues and closely associated with lymphatic metastases. HOXA11 transcriptionally regulates TGFβ1 expression and activates the TGFβ1/Smad2 pathway, which not only promotes EMT development but also induces VEGF-C secretion and lymphangiogenesis. These findings provide a plausible mechanism for HOXA11-modulated tumor in lymphatic metastasis and suggest that HOXA11 may represent a potential therapeutic target for clinical intervention in LN-metastatic gastric cancer., Competing Interests: The authors declare no competing interests., (© 2023 The Authors.) more...
- Published
- 2023
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193. Clusterin regulates TRPM2 to protect against myocardial injury induced by acute myocardial infarction injury.
- Author
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Li D, Wang M, Fan R, Song Z, Li Z, Gan H, and Fan H
- Subjects
- Animals, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Clusterin genetics, Clusterin metabolism, Myocardial Infarction genetics, TRPM Cation Channels genetics, TRPM Cation Channels metabolism
- Abstract
Background: Clusterin and transient receptor potential melastatin 2 (TRPM2) play significant roles in acute myocardial infarction (AMI), but their interactions in AMI are unclear., Methods: Myocardial infarction was induced by ligation of the left anterior descending coronary artery in wild-type C57BL/6J male mice. Infarct size and myocardium pathology were evaluated after 6, 12, and 24 h of ischemia. The expression levels of clusterin and TRPM2 were measured in the myocardium. Furthermore, myocardial infarction was induced in TRPM2 knockout (TRPM2
-/- ) C57BL/6J male mice to evaluate the expression of clusterin. H9C2 cells with various levels of TRPM2 expression were used to analyze the effects of clusterin under hypoxic conditions., Results: Following AMI, myocardial hypertrophy and TRPM2 expression increased in a time-dependent manner. In contrast, the expression of clusterin decreased in an infarct time-dependent manner. Knockout of TRPM2 protected against myocardial injury and resulted in upregulation of clusterin. In the H9C2 cells, cultured under hypoxic conditions treatment with clusterin or silencing of TRPM2 significantly increased cell viability and decreased TRPM2 expression. Treatment with clusterin protected against TRPM2 overexpression-induced damage in hypoxia-treated H9C2 cells., Conclusion: This study characterized the effects of clusterin on TRPM2 in AMI, which may guide development of new treatment strategies for AMI., Competing Interests: Conflict of interest There is no any conflict of interest., (Copyright © 2023 Elsevier Ltd. All rights reserved.) more...- Published
- 2023
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194. Anti-SARS-CoV-2 IgG levels in relation to disease severity of COVID-19.
- Author
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Yan X, Chen G, Jin Z, Zhang Z, Zhang B, He J, Yin S, Huang J, Fan M, Li Z, Chen F, Zeng Y, Han X, and Zhu Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Asymptomatic Infections, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Time Factors, Young Adult, Antibodies, Viral blood, COVID-19 pathology, Immunoglobulin G blood, SARS-CoV-2 immunology, Severity of Illness Index
- Abstract
The durability of infection-induced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity has crucial implications for reinfection and vaccine effectiveness. However, the relationship between coronavirus disease 2019 (COVID-19) severity and long-term anti-SARS-CoV-2 immunoglobulin G (IgG) antibody level is poorly understood. Here, we measured the longevity of SARS-CoV-2-specific IgG antibodies in survivors who had recovered from COVID-19 1 year previously. In a cohort of 473 survivors with varying disease severity (asymptomatic, mild, moderate, or severe), we observed a positive correlation between virus-specific IgG antibody titers and COVID-19 severity. In particular, the highest virus-specific IgG antibody titers were observed in patients with severe COVID-19. By contrast, 74.4% of recovered asymptomatic carriers had negative anti-SARS-CoV-2 IgG test results, while many others had very low virus-specific IgG antibody titers. Our results demonstrate that SARS-CoV-2-specific IgG persistence and titer depend on COVID-19 severity., (© 2021 Wiley Periodicals LLC.) more...
- Published
- 2022
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195. Protective effect of COMP-angiopoietin-1 on peritoneal vascular permeability and peritoneal transport function in uremic peritoneal dialysis rats.
- Author
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Shi Y, Xiong Y, Lei Y, Li Z, Yan H, Yuan J, Ding F, and Fang W
- Abstract
The angiopoietin-1 (Ang-1)/Tie-2 signaling pathway plays a crucial role in the maintenance of vascular stabilization and permeability. In this study, we evaluated the protective effect of a designed Ang-1 variant (COMP-Ang-1) on peritoneal vascular permeability and peritoneal transport function in a uremic peritoneal dialysis (PD) model. Compared to the sham controls, uremic rats were characterized by decreased pericyte coverage and downregulated endothelial junction expression. The permeability of the peritoneal vasculature to FITC-BSA and FITC-dextran in uremic rats was also higher than that in the sham controls, as well as increased levels of proinflammatory adhesion molecules and cytokines, increased D/P
cr and decreased ultrafiltration. Such changes were more marked in uremia+PD rats after exposure to glucose-based peritoneal dialysis fluid (PDF) for 4 weeks. Peritoneal Ang-1 protein expression and Tie-2 phosphorylation were significantly lower in uremic rats than in control rats and were further significantly reduced in uremia+PD rats. After COMP-Ang-1 administration, phosphorylation of the Tie-2 receptor was significantly increased. Treatment with COMP-Ang-1 also significantly enhanced pericyte coverage, upregulated endothelial junction protein expression and inhibited leakage of FITC-BSA and FITC-dextran from the peritoneal vasculature induced during PD therapy; these changes were accompanied by reduced peritoneal tissue levels of proinflammatory adhesion molecules and cytokines, decreased D/Pcr and increased ultrafiltration. These findings suggest that COMP-Ang-1 may exert a protective effect against glucose-based PDF-induced peritoneal vascular permeability and inflammation, at least in part, by enhancing pericyte coverage and endothelial junction protein expression, which subsequently significantly improves peritoneal transport function., Competing Interests: None., (AJTR Copyright © 2019.) more...- Published
- 2019
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