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Objective: To discover biomarkers and uncover the mechanism of Cold/Hot ZHENG (syndrome in traditional Chinese medicine) chronic gastritis (CG) and Cold/Hot herbs in traditional Chinese medicine (TCM) formulae on systematic biology. Background: CG is a common inflammatory disease and the diagnosis of CG in TCM can be classified into Cold ZHENG (Asthenic Cold) and Hot ZHENG (Excess Hot). However, the molecular features of Cold/Hot ZHENG in CG and the mechanism of Cold/Hot herbs in formulae for CG remained unclear. Methods: Based on data of 35 patients of Cold/Hot ZHENG CG and 3 scRNA-seq CG samples, we conduct analysis with transcriptomics datasets and algorithms, to discover biomarkers for Cold/Hot ZHENG CG. And we collected 25 formulae (with traditional effects related to Cold/Hot ZHENG) for CG and corresponding 89 Cold/Hot herbs (including Warm/Cool herbs) to discover features and construct target networks of Cold/Hot herbs on the basis of network target and enrichment analysis. Results: Biomarkers of Cold/Hot ZHENG CG represented by CCL2 and LEP suggested that Hot ZHENG CG might be characterized by over-inflammation and exuberant metabolism, and Cold ZHENG CG showed a trend of suppression in immune regulation and energy metabolism. And biomarkers of Cold/Hot ZHENG showed also significant changes in the progression of gastric cancer. And biomarkers and pathways of Hot herbs intend to regulate immune responses and energy metabolism, while those of Cold herbs were likely to participate in anti-inflammation effect. Conclusion: In this study, we found that the biomarkers and mechanism of Cold/Hot ZHENG CG and those of Cold/Hot herbs were closely related to the regulation of immune and metabolisms. These findings may reflect the mechanism, build bridges between multiple views of Cold/Hot ZHENG and Cold/Hot herbs, and provide a research paradigm for further achieving precision TCM., Comment: 17 pages (references not included), 7 figures

The connection between a hidden nonthermal sector and a thermal plasma can be established by a light thermal fermion mediator. When the fermion mediator is much lighter than the hidden species, kinematically forbidden decay of the mediator can be opened at finite temperatures to produce the hidden species. Unlike bosons having quartic couplings, renormalizable forbidden fermion decay generically shares the same order of couplings with the scattering. We present a dedicated investigation into the freeze-in dark matter production via a thermal fermion mediator. We demonstrate that the plasma-induced decay rate differs from that calculated via the tree-level amplitude, but the former can be obtained from the latter via constant rescaling. Furthermore, we find that the relative effect of the forbidden decay and the scattering on the dark matter relic density can be simply estimated via the thermal coupling between the plasma and the mediator. Applying to different thermal interactions, we show that the forbidden decay contribution can reach the level of $4\%-45\%$ for a thermal coupling at $0.1-1$., Comment: 29 pages, 6 figures, 1 table, 1 appendix, version accepted for publication in JCAP

The migration motion of defects in metal halide perovskites quantum dots (MHPQDs) results in charge-carrier trapping become more complicated. We study two-step trapping mediated by mobile defects between the ground state of MHPQDs and a fixed-depth defect using a full-configuration defect method, where all possible trapping processes mediated by these mobile defects could be reproduced and the fastest channels among them are picked out. We find that these two-step trapping processes could keep more one order of magnitude faster than these direct ones as mobile defect with the appropriate localization strength, which implies that these indirect trapping should play the crucial rule to determine the non-radiative recombination losses. These results provide the significant explanation for studying non-radiation processes of carriers in the presence of the migration defects in recent experiments. Moreover, this model will be available to analyze some key performance related defects in electronic devices., Comment: 5 pages, 3 figures

Right-handed neutrinos (RHNs) provide a natural portal to a dark sector accommodating dark matter (DM). In this work, we consider that the dark sector is connected to the standard model only via RHNs and ask how DM can be produced from RHNs. Our framework concentrates on a rather simple and generic interaction that couples RHNs to a pair of dark particles. Depending on whether RHNs are light or heavy in comparison to the dark sector and also on whether one or both of them are in the freeze-in/out regime, there are many distinct scenarios resulting in rather different results. We conduct a comprehensive and systematic study of all possible scenarios in this paper. For illustration, we apply our generic results to the type-I seesaw model with the dark sector extension, addressing whether and when DM in this model can be in the freeze-in or freeze-out regime. Some observational consequences in this framework are also discussed., Comment: 33 pages, 5 figures; calculations on non-thermal spectra added; matching the JCAP published version

We theoretically study the optical absorption of an angulon in the metal halide perovskites (MHP) based on the improved Devreese-Huybrechts-Lemmens model, where the formation of quasiparticle angulon states originates from the organic cation rotating in the inorganic octahedral cage of MHP. We find that the resonance optical absorption peaks are appeared when the energy of incident photon matches the quantum levels of angulon. Moreover, the intensity of absorption depends on the quantum states of phonon angular momentum. These theoretical results provide significant insight to study the redistribution of angular momenta for the rotational molecules immersed into the many-body environment., Comment: 10 pages, 2 figures

It is generically believed that the two-body scattering is suppressed by higher-order weak couplings with respect to the two-body decay. We show that this does not always hold when a heavy particle is produced by forbidden decay in a thermal plasma, where the scattering shares the same order of couplings with the decay. We find that there is a simple and close relation between the forbidden decay and the same-order scattering. To illustrate this point, we consider freeze-in production of heavy dark matter via a light scalar mediator. We point out that, when the Boltzmann (quantum) statistics is used, the forbidden decay can contribute to the dark matter relic density at 5$\%$-24$\%$ (10$\%$-$39\%$) with a weak thermal coupling, while the contribution from the scattering channel can be several orders of magnitude larger than from the forbidden decay if the thermal coupling is much smaller. Such a relative effect between the scattering and the forbidden decay could also exist in other plasma-induced processes, such as the purely thermal generation of the right-handed neutrino dark matter, or of the lepton asymmetry in leptogenesis., Comment: 8 pages, 3 figures, version accepted for publication in PRD

Magnetic monopoles have been realized as emergent quasiparticles in both condensed matter and ultracold atomic platforms, with growing interests in the coupling effects between the monopole and different magnetic quasiparticles. In this work, interaction effects between monopoles and magnons are investigated for an atomic pseudospin chain. We reveal that the monopole can excite a virtual magnon cloud in the paramagnetic chain, thereby giving rise to a new type of polaron, the monopole-cored polaron (McP). The McP is composed of the monopole as the impurity core and the virtual magnon excitation as the dressing cloud. The magnon dressing facilitates the Dirac string excitation and impacts the monopole hopping. This induces an anti-trapping effect of the McP, which refers to the fact that the dressing enhances the mobility of the McP, in contrast to the self-trapping of the common polarons. Moreover, heterogeneous bipolarons are shown to exist under the simultaneous doping of a north and a south monopole. The heterogeneous bipolaron possesses an inner degree of freedom composed of two identical impurities. Our investigation sheds light on the understanding of how the coupling between the impurity core and the dressing cloud can engineer the property of the polaron

A rapidly rotating and highly magnetized remnant neutron star (NS; magnetar) could survive from a merger of double NSs and drive a powerful relativistic wind. The early interaction of this wind with the previous merger ejecta can lead to shock breakout (SBO) emission mainly in ultraviolet and soft X-ray bands, which provides an observational signature for the existence of the remnant magnetar. Here we investigate the effect of an anisotropic structure of the merger ejecta on the SBO emission. It is found that bolometric light curve of the SBO emission can be broadened, since the SBO can occur at different times for different directions. In more detail, the profile of the SBO light curve can be highly dependent on the ejecta structure and, thus, we can in principle use the SBO light curves to probe the structure of the merger ejecta in future., Comment: Contribution to the Special Issue "Advances in Astrophysics and Cosmology-in Memory of Prof. Tan Lu"

In the early universe, Dirac neutrino magnetic moments due to their chirality-flipping nature could lead to thermal production of right-handed neutrinos, which would make a significant contribution to the effective neutrino number, $N_{\rm eff}$. We present in this paper a dedicated computation of the neutrino chirality-flipping rate in the thermal plasma. With a careful and consistent treatment of soft scattering and the plasmon effect in finite temperature field theories, we find that neutrino magnetic moments above $2.7\times 10^{-12}\mu_B$ have been excluded by current CMB and BBN measurements of $N_{\rm eff}$, assuming flavor-universal and diagonal magnetic moments for all three generation of neutrinos. This limit is stronger than the latest bounds from XENONnT and LUX-ZEPLIN experiments, and comparable with those from stellar cooling considerations., Comment: 23 pages, 6 figures, 2 tables. An appendix added to demonstrate the consistency with early results

Deep neural networks trained with standard cross-entropy loss are more prone to memorize noisy labels, which degrades their performance. Negative learning using complementary labels is more robust when noisy labels intervene but with an extremely slow model convergence speed. In this paper, we first introduce a bidirectional learning scheme, where positive learning ensures convergence speed while negative learning robustly copes with label noise. Further, a dynamic sample reweighting strategy is proposed to globally weaken the effect of noise-labeled samples by exploiting the excellent discriminatory ability of negative learning on the sample probability distribution. In addition, we combine self-distillation to further improve the model performance. The code is available at \url{https://github.com/chenchenzong/BLDR}.

Ultracold spinor atoms in the weak and strong interaction regime have received extensive investigations, while the behavior in the intermediate regime is less understood. We numerically investigate ultracold spinor atomic ensembles of finite size in the intermediate interaction regime, and reveal the evolution of the eigenstates from the strong to the intermediate regime. In the strong interaction regime, it has been well known that the low-lying eigenenergy spectrum presents the well-gaped multi-manifold structure, and the energy gaps protect the categorization of the eigenstates. In the intermediate interaction regime, it is found that the categorization of the eigenstates is preserved, and the eigenenergy spectrum become quasi-continuum, with different manifolds becoming overlapped. The overlapping induces both direct and avoided crossings between close-lying manifolds, which is determined by the combined symmetries of the eigenstates involved in the crossing. A modified t-J model is derived to describe the low-lying eigenstates in the intermediate regime, which can capture the formation and crossings of the manifolds. State preparation through the avoided crossings is also investigated., Comment: 8 pages,6 figures

If the leptoquarks proposed to account for the intriguing anomalies observed in the $B$-meson decays, $R_{D^{(\ast)}}$ and $R_{K^{(\ast)}}$, as well as in the anomalous magnetic moment of the muon, $(g-2)_\mu$, can be embedded into the scotogenic Dirac neutrino model, all these flavor anomalies, together with the origin of neutrino masses and the nature of dark matter, would be potentially addressed in a unified picture. Among the minimal seesaw, one-loop, and two-loop realizations of the dimension-4 effective operator $\mathcal{L}_{4}$ for the Dirac neutrino masses, we show that plenty of diagrams associated with the two-loop realizations of $\mathcal{L}_{4}$ can support the coexistence of leptoquarks and dark matter candidates. After a simple match of these leptoquarks to those that can accommodate all the flavor anomalies, we establish the scotogenic Dirac neutrino models embedded with leptoquarks, which could address all the problems mentioned above., Comment: 15 pages, 16 tables, 9 figures

If the Dirac neutrino masses are generated by a new scalar doublet with a vacuum at keV order, there would be rare hope to probe the framework in low-energy flavor physics, such as the lepton-flavor violating processes. However, the predicted neutrino Yukawa couplings being around the order of electronic Yukawa can realize a purely thermal Dirac leptogenesis, and thus render a more direct link between the high- and the low-energy CP violation. Despite its inert property in the low-energy flavor processes, the keV-vacuum induced Dirac neutrino model can generate a significant shift of the effective neutrino number, which can in turn be probed by the big-bang nucleosynthesis and cosmic microwave background epochs. We show that such a keV-vacuum induced Dirac neutrino model is already constrained by the current observations and will be probed with forecast sensitivity, serving therefore as a complementary avenue to test the Dirac leptogenesis., Comment: 8 pages, and 3 figures