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163. The inhibitory effect of compound ChlA-F on human bladder cancer cell invasion can be attributed to its blockage of SOX2 protein

Author

Hua, Xiaohui, primary, Huang, Maowen, additional, Deng, Xu, additional, Xu, Jiheng, additional, Luo, Yisi, additional, Xie, Qipeng, additional, Xu, Jiawei, additional, Tian, Zhongxian, additional, Li, Jingxia, additional, Zhu, Junlan, additional, Huang, Chao, additional, Zhao, Qin-shi, additional, Huang, Haishan, additional, and Huang, Chuanshu, additional

Published
2019
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168. ATG7 Promotes Bladder Cancer Invasion via Autophagy‐Mediated Increased ARHGDIB mRNA Stability

Author

Zhu, Junlan, primary, Tian, Zhongxian, additional, Li, Yang, additional, Hua, Xiaohui, additional, Zhang, Dongyun, additional, Li, Jingxia, additional, Jin, Honglei, additional, Xu, Jiheng, additional, Chen, Wei, additional, Niu, Beifang, additional, Wu, Xue‐Ru, additional, Comincini, Sergio, additional, Huang, Haishan, additional, and Huang, Chuanshu, additional

Published
2019
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170. Underwater target detection of chaotic pulse laser radar

Author

Shen Zhenmin, 沈振民, primary, Zhao Tong, 赵 彤, additional, Wang Yuncai, 王云才, additional, Zheng Yongchao, 郑永超, additional, Shang Weidong, 尚卫东, additional, Wang Bingjie, 王冰洁, additional, and Li Jingxia, 李静霞, additional

Published
2019
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172. Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer

Author

Jin, Honglei, primary, Xue, Lei, additional, Mo, Lan, additional, Zhang, Dongyun, additional, Guo, Xirui, additional, Xu, Jiheng, additional, Li, Jingxia, additional, Peng, Minggang, additional, Zhao, Xuewei, additional, Zhong, Minghao, additional, Xu, Dazhong, additional, Wu, Xue-Ru, additional, Huang, Haishan, additional, and Huang, Chuanshu, additional

Published
2019
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177. Decreased c-Myc mRNA Stability via the MicroRNA 141-3p/AUF1 Axis Is Crucial for p63α Inhibition of Cyclin D1 Gene Transcription and Bladder Cancer Cell Tumorigenicity

Author

Li, Xin, primary, Tian, Zhongxian, additional, Jin, Honglei, additional, Xu, Jiheng, additional, Hua, Xiaohui, additional, Yan, Huiying, additional, Liufu, Huating, additional, Wang, Jingjing, additional, Li, Jingxia, additional, Zhu, Junlan, additional, Huang, Haishan, additional, and Huang, Chuanshu, additional

Published
2018
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178. Artifacts Suppression Using Correlation-Weighted Back Projection Imaging Algorithm for Chaotic GPR.

Author

Li, Jingxia, Chen, Xinpeng, Xu, Hang, Wang, Bingjie, Zhang, Jianguo, Liu, Li, and Shen, Zhenmin

Abstract

A correlation weighted back projection (CWBP) imaging algorithm is proposed to suppress artifacts introduced by the classic back projection (BP) algorithm in the application of chaotic ground-penetrating radar (GPR). In the proposed CWBP algorithm, the backscattering response to each point in the imaging region is first reconstructed through the weighting, which is used to highlight the backscattering response of targets. Then the quadratic cross correlation is calculated to reduce the nontargets’ backscattering. The experimental results show that the artifacts are significantly suppressed. In addition, the ghosts generated by overlapped of multitargets artifacts in the classic BP are removed. Our results also show that the proposed CWBP can be applied for the stepped frequency continuous wave radar. [ABSTRACT FROM AUTHOR]

Published
2021
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179. Donor Plasmacytoid Dendritic Cells Limit Graft Versus Host Disease Through Vasoactive Intestinal Polypeptide Expression

Author

Zhu, Jingru, Wang, Yitong, Li, Jingxia, Das, Pankoj Kumar, Zhang, Hanwen, Passang, Tenzin, Li, Jian Ming, Nagy, Tamas, Gandhi, Khanjan, Ravindranathan, Sruthi, Giver, Cynthia R., Hassan, Mojibade, Li, Yiwen, Antonova, Alina Ulezko, Wang, Shuhua, Roback, John D., and Waller, Edmund K.

Abstract

Vasoactive intestinal peptide (VIP), an anti-inflammatory neuropeptide with pleiotropic cardio-vascular effects, induces differentiation of hematopoietic stem cells into regulatory dendritic cells that limit graft-versus-host disease (GvHD) in allogeneic hematopoietic stem cell transplant (HSCT) recipients. We have previously shown that donor plasmacytoid dendritic cells (pDCs) in bone marrow (BM) donor grafts limit the pathogenesis of GvHD. In this current study we show that murine and human pDCs express VIP, and that VIP-expressing pDCs limit T cell activation and expansion using both in vivo and in vitro model systems. Using T cells or pDCs from transgenic luciferase+ donors in murine BMT, we show similar homing patterns of donor pDCs and T cells to the major sites for allo-activation of donor T cells: spleen, and gut. Co-transplanting VIP-KO pDCs with hematopoietic stem cells (HSCs) and T cells in MHC mis-matched allogeneic BMT led to lower survival, higher GvHD scores, and more colon crypt cell apoptosis than transplanting wild-type pDCs. BMT recipients of VIP-KO pDCs had more Th1 polarized T cells, and higher plasma levels of GM-CSF and TNF-alpha than recipients of wild-type pDCs. T cells from VIP-KO pDC recipients had increasing levels of bhlhe40transcripts during the first two weeks post-transplant, and higher levels of CyclophilinA/Ppiatranscripts at day 15 compared with T cells from recipients of wild type pDCs. Collectively, these data indicate paracrine VIP synthesis by donor pDCs limits pathogenic T cell inflammation, supporting a novel mechanism by which donor immune cells regulate T cell activation and GvHD in allogeneic BMT.

Published
2024
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187. XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin‐mediated Rho‐GDIβ mRNA stability

Author

Yu, Yonghui, primary, Jin, Honglei, additional, Xu, Jiheng, additional, Gu, Jiayan, additional, Li, Xin, additional, Xie, Qipeng, additional, Huang, Haishan, additional, Li, Jingxia, additional, Tian, Zhongxian, additional, Jiang, Guosong, additional, Chen, Caiyi, additional, He, Feng, additional, Wu, Xue‐Ru, additional, and Huang, Chuanshu, additional

Published
2017
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191. Isorhapontigenin (ISO) inhibits malignant cell transformation, migration, and invasion through MEG3/NEDD9 signaling in Cr(VI)-transformed cells.

Author

Shi, Sophia, Li, Jingxia, Zhang, Zhuo, Tu, Huailu, and Max, Costa

Subjects
*CELL transformation, *CANCER cells, *LINCRNA, *WNT proteins, *GENE expression, *WNT signal transduction, *CELL cycle regulation, *CELL cycle
Abstract

Cr(VI) compounds are confirmed human carcinogens. Maternally expression 3 (MEG3) is the first long non-coding RNA to be identified as a tumor suppressor. MEG3 is frequently downregulated or lost in various primary human tumor tissues and cancer cell lines. Downregulation of MEG3 is associated with cancer initiation, progression, and metastasis. Our previous study has revealed that MEG3 was lost and NEDD9 was upregulated in Cr(VI)-transformed cells compared to those in passage-matched normal BEAS-2B cells. Overexpression of MEG3 reduced NEDD9. β-Catenin was activated in Cr(VI)-transformed cells, overexpression of MEG3 or knockdown of NEDD9 inhibited the activation of β-Catenin. The results from the present study showed that isorhapontigenin (ISO) treatment is able to suppress cell proliferation, migration, and invasion of Cr(VI)-transformed cells. Further study showed that ISO treatment in Cr(VI)-transformed cells decreases the levels of Ki67, a biomarker for cell proliferation, and of cyclin D1, a regulator for the cell cycle. ISO elevated the MEG3 expression level in Cr(VI)-transformed cells. The DNA methylation transferases DNMT3a, DNMT3b, and DNMT1 levels were reduced upon ISO treatment. ISO treatment decreased both mRNA and protein levels of NEDD9. In addition, ISO treatment reduced the activation of β-catenin. Slug was upregulated and E -Cadherin was downregulated in Cr(VI)-transformed cells, treatment with ISO decreased Slug and increased E -Cadherin. This study demonstrated that ISO is a potent therapeutical agent against lung cancer induced by Cr(VI). • Cr(VI) is a confirmed human carcinogen. • ISO is an orally bioavailable dietary polyphenol. • ISO inhibits proliferation of Cr(VI)-transformed cells. • ISO inhibits of migration and invasion of Cr(VI)-transformed cells. [ABSTRACT FROM AUTHOR]

Published
2023
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192. Isorhapontigenin (ISO) inhibits invasive bladder cancer (BC) formation in vivo and human BC invasion in vitro by targeting STAT1/FOXO1 Axis

Author

Jiang, Guosong, Wu, Amy D., Huang, Chao, Gu, Jiayan, Zhang, Liping, Huang, Haishan, Liao, Xin, Li, Jingxia, Zhang, Dongyun, Zeng, Xingruo, Jin, Honglei, Huang, Haojie, and Huang, Chuanshu

Subjects
Forkhead Box Protein O1, Antineoplastic Agents, Interferon-Stimulated Gene Factor 3, Article, Mice, Inbred C57BL, Mice, Random Allocation, Urinary Bladder Neoplasms, Cell Movement, Cell Line, Tumor, Stilbenes, Animals, Humans, Matrix Metalloproteinase 2, Neoplasm Invasiveness, Signal Transduction
Abstract

Although our most recent studies have identified Isorhapontigenin (ISO), a novel derivative of stilbene that isolated from a Chinese herb Gnetum cleistostachyum, for its inhibition of human bladder cancer growth, nothing is known whether ISO possesses an inhibitory effect on bladder cancer invasion. Thus, we addressed this important question in current study and discovered that ISO treatment could inhibit mouse-invasive bladder cancer development following bladder carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) exposure in vivo We also found that ISO suppressed human bladder cancer cell invasion accompanied by upregulation of the forkhead box class O 1 (FOXO1) mRNA transcription in vitro Accordingly, FOXO1 was profoundly downregulated in human bladder cancer tissues and was negatively correlated with bladder cancer invasion. Forced expression of FOXO1 specifically suppressed high-grade human bladder cancer cell invasion, whereas knockdown of FOXO1 promoted noninvasive bladder cancer cells becoming invasive bladder cancer cells. Moreover, knockout of FOXO1 significantly increased bladder cancer cell invasion and abolished the ISO inhibition of invasion in human bladder cancer cells. Further studies showed that the inhibition of Signal transducer and activator of transcription 1 (STAT1) phosphorylation at Tyr701 was crucial for ISO upregulation of FOXO1 transcription. Furthermore, this study revealed that metalloproteinase-2 (MMP-2) was a FOXO1 downstream effector, which was also supported by data obtained from mouse model of ISO inhibition BBN-induced mouse-invasive bladder cancer formation. These findings not only provide a novel insight into the understanding of mechanism of bladder cancer's propensity to invasion, but also identify a new role and mechanisms underlying the natural compound ISO that specifically suppresses such bladder cancer invasion through targeting the STAT1-FOXO1-MMP-2 axis. Cancer Prev Res; 9(7); 567-80. ©2016 AACR.

Published
2016

193. RhoGDIβ promotes Sp1/MMP-2 expression and bladder cancer invasion through perturbing miR-200c-targeted JNK2 protein translation

Author

Huang, Haishan, primary, Jin, Honglei, additional, Zhao, Huirong, additional, Wang, Jingjing, additional, Li, Xin, additional, Yan, Huiying, additional, Wang, Shuai, additional, Guo, Xirui, additional, Xue, Lei, additional, Li, Jingxia, additional, Peng, Minggang, additional, Wang, Annette, additional, Zhu, Junlan, additional, Wu, Xue-Ru, additional, Chen, Changyan, additional, and Huang, Chuanshu, additional

Published
2017
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