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911 results on '"Li, Dehai"'

157. Dothideomins A–D, Antibacterial Polycyclic Bisanthraquinones from the Endophytic Fungus Dothideomycetessp. BMC-101

Author

Wang, Lusheng, Zong, Shikun, Wang, Haotian, Wu, Chengzhu, Wu, Guangwei, Li, Feng, Yu, Guihong, Li, Dehai, and Zhu, Meilin

Abstract

Four new bisanthraquinones, dothideomins A–D (1–4), were identified from Dothideomycetessp. BMC-101, an endophytic fungus isolated from Magnolia grandiflora L. leaves. Their chemical structures were established by NMR analysis, single-crystal X-ray crystallography, and ECD analysis. Dothideomins A–D (1–4) were characterized by an unusual 6/6/6/5/6/3/6/6 octocyclic scaffold (1and 2) and a 6/6/6/5/6/6/6 heptacyclic scaffold (3and 4), respectively. All compounds, especially 1and 3, exhibited potent antibacterial activity with MIC values ranging from 0.4 to 0.8 μg/mL.

Published
2022
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167. Superposition model for analyzing the dynamic ground subsidence in mining area of thick loose layer

Author

Li Dehai, Zhang Yanbin, Xu Guosheng, and Hou Defeng

Subjects
lcsh:TN1-997, geography, geography.geographical_feature_category, Deformation (mechanics), Field (physics), Bedrock, Coordinate system, 0211 other engineering and technologies, Underground mining (hard rock), Energy Engineering and Power Technology, Subsidence (atmosphere), 02 engineering and technology, Geotechnical Engineering and Engineering Geology, Physics::Geophysics, Superposition principle, 020401 chemical engineering, Geochemistry and Petrology, Geotechnical engineering, 0204 chemical engineering, lcsh:Mining engineering. Metallurgy, Geology, Beam (structure), 021101 geological & geomatics engineering
Abstract

The dynamic ground subsidence due to underground mining is a complicated time-dependent and rate-dependent process. Based on the theory of rock rheology and probability integral method, this study developed the superposition model for the prediction and analysis of the ground dynamic subsidence in mining area of thick loose layer. The model consists of two parts (the prediction of overlying bedrock and the prediction of thick loose layer). The overlying bedrock is regarded as visco-elastic beam, of which the dynamic subsidence is predicted by the Kelvin visco-elastic rheological model. The thick loose layer is regarded as random medium and the ground dynamic subsidence is predicted by the probability integral model. At last, the two prediction models are vertically stacked in the same coordinate system, and the bedrock dynamic subsidence is regarded as a variable mining thickness input into the prediction model of ground dynamic subsidence. The prediction results obtained were compared with actual movement and deformation data from Zhao I and Zhao II mine, central China. The agreement of the prediction results with the field measurements show that the superposition model (SM) is more satisfactory and the formulae obtained are more effective than the classical single probability integral model (SPIM), and thus can be effectively used for predicting the ground dynamic subsidence in mining area of thick loose layer. Keywords: Thick loose layer, Dynamic groundsubsidence, Kelvin visco-elastic rheological model, Random medium, Single probability integral model, Superposition model

Published
2018

171. Secondary Metabolites from Deep-Sea Derived Microorganisms

Author

Sun, Chunxiao, primary, Mudassir, Shah, additional, Zhang, Zhenzhen, additional, Feng, Yanyan, additional, Chang, Yimin, additional, Che, Qian, additional, Gu, Qianqun, additional, Zhu, Tianjiao, additional, Zhang, Guojian, additional, and Li, Dehai, additional

Published
2020
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172. Production of Multiple Talaroenamines from Penicillium malacosphaerulumvia One-Pot/Two-Stage Precursor-Directed Biosynthesis

Author

Zhang, Zhenzhen, He, Xueqian, Zhang, Xiaomin, Li, Dehai, Wu, Guangwei, Liu, Zhenzhen, Niu, Chao, Yang, Lanping, Song, Wenting, Li, Zhanlin, and Wang, Zhenhui

Abstract

Nineteen new talaroenamine derivatives, talaroenamines F1–F19 (1–19), were isolated from the Yellow River wetland derived Penicillium malacosphaerulumHPU-J01 by use of a one-pot/two-stage precursor-directed biosynthesis approach. During this approach, the initial precursor p-methylaniline was first used as a carrier to capture the biologically synthesized cyclohexanedione to produce talaroenamine F, and then the other aniline derivatives were employed to replace the p-methylaniline fragment of talaroenamine F to generate the final products. LC–MS analysis showed that only four compounds (2, 8, 10, and 12) could be produced by the traditional precursor-directed biosynthesis in which the aniline precursors were added simultaneously. Compound 14was cytotoxic against the K562 cell line with an IC50value of 2.2 μM. This work demonstrated the one-pot/two-stage precursor-directed biosynthesis could improve substrate acceptance leading to the production of diverse talaroenamines.

Published
2022
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183. Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD

Author

Wang, Qian, primary, Li, Dehai, additional, Zhu, Jing, additional, Zhang, Mingyue, additional, Zhang, Hua, additional, Cao, Guangchao, additional, Zhu, Leqing, additional, Shi, Qiping, additional, Hao, Jianlei, additional, Wen, Qiong, additional, Liu, Zonghua, additional, Yang, Hengwen, additional, and Yin, Zhinan, additional

Published
2020
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187. [1,5]-Hydride Shift-Cyclization versus C(sp2)-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines

Author

Szalóki Vargáné, Dóra, primary, Tóth, László, additional, Buglyó, Balázs, additional, Kiss-Szikszai, Attila, additional, Mándi, Attila, additional, Mátyus, Péter, additional, Antus, Sándor, additional, Chen, Yinghan, additional, Li, Dehai, additional, Tao, Lingxue, additional, Zhang, Haiyan, additional, and Kurtán, Tibor, additional

Published
2020
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196. Talaverrucin A, Heterodimeric Oxaphenalenone from Antarctica Sponge-Derived Fungus Talaromycessp. HDN151403, Inhibits Wnt/β-Catenin Signaling Pathway

Author

Sun, Chunxiao, Liu, Qianwen, Shah, Mudassir, Che, Qian, Zhang, Guojian, Zhu, Tianjiao, Zhou, Jianfeng, Rong, Xiaozhi, and Li, Dehai

Abstract

The Wnt/β-catenin signaling pathway is an evolutionarily conserved signaling cascade involved in a broad range of biological roles. Dysregulation of the Wnt/β-catenin pathway is implicated in congenital malformations and various kinds of cancers. We discovered a novel Wnt/β-catenin inhibitor, talaverrucin A (1), featuring an unprecedented 6/6/6/5/5/5/6 fused ring system, from an Antarctica sponge-derived fungus Talaromycessp. HDN151403. Talaverrucin A exhibits inhibitory activity on the Wnt/β-catenin pathway in both zebrafish embryos in vivoand cultured mammalian cells in vitro, providing a naturally inspired small molecule therapeutic lead to target the Wnt/β-catenin pathway.

Published
2022
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197. Linear polyketides produced by co-culture of Penicillium crustosumand Penicillium fellutanum

Author

Yu, Guihong, Sun, Peng, Aierken, Reyilamu, Sun, Chunxiao, Zhang, Zhenzhen, Che, Qian, Zhang, Guojian, Zhu, Tianjiao, Gu, Qianqun, Li, Mingyu, and Li, Dehai

Abstract

Two new polyketides, penifellutins A (1) and B (2), possessing a 22 carbon linear skeleton, were isolated from a co-culture of the deep-sea-derived fungi Penicillium crustosumPRB-2 and Penicillium fellutanumHDN14-323. Meanwhile, two esterification products of 1, penifellutins C (3) and D (4), were obtained because compound 1could be esterified spontaneously when stored in methanol. Their configurations were difficult to determine because of chiral central crowdedness, structural flexibility and instability. As such, we solved this issue by comprehensively using Mo2(OAc)4-based CD experiments, density functional theory calculation of 13C NMR, DP4 + probability analysis and many chemical reactions, including making acetonide derivative, Mosher’s method, PGME method, etc. Compounds 1and 2show obvious inhibitory activity on the liver hyperplasia of zebrafish larvae at a concentration of 10 μmol/L, while 3and 4show no activity, indicating that two carboxyls in the structure are important active sites.

Published
2022
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200. Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury

Author

Zhang, Hua, primary, Sun, Guodong, additional, Li, Xiaowei, additional, Fu, Zhen, additional, Guo, Chengbin, additional, Cao, Guangchao, additional, Wang, Baocheng, additional, Wang, Qian, additional, Yang, Shuxian, additional, Li, Dehai, additional, Xia, Xichun, additional, Li, Peng, additional, Zhu, Jing, additional, Zhou, Wei, additional, Zheng, Liangyan, additional, Li, Jingxia, additional, Zhang, Lei, additional, Hao, Jianlei, additional, Zhou, Libing, additional, Bornancin, Frederic, additional, Li, Zhizhong, additional, Yin, Zhinan, additional, and Gao, Yunfei, additional

Published
2019
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