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151. FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study (Preprint)

Author

Daugherty, Emily C, primary, Mascia, Anthony E, additional, Zhang, Yongbin, additional, Lee, Eunsin, additional, Xiao, Zhiyan, additional, Sertorio, Mathieu, additional, Woo, Jennifer, additional, McCann, Claire, additional, Russell, Ken, additional, Levine, Lisa L, additional, Sharma, Ricky A, additional, Khuntia, Deepak, additional, Bradley, Jeffrey, additional, Simone 2nd, Charles B, additional, Perentesis, John P, additional, and Breneman, John C, additional

Published
2022
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152. Variation in the Prediction of Cross-Cultural Adjustment by Asian-Indian Students in the United States

Author

Tochkov, Karin, Levine, Lisa, and Sanaka, Amritha

Abstract

Homesickness is a major stressor for college students in general, and international students in particular, that has an adverse effect on their psychological health and academic performance. The present study examined the incidence and determinants of homesickness in a sample of international students from India attending a US university and compared the results to a control group consisting of American students in their freshman year. The results indicated that homesickness was significantly more prevalent in the Indian sample. For Indian students, anxiety and depression were positively correlated with homesickness, whereas financial aid, course load, and the intention to look for a job in the US after graduation had the opposite effect. The length of stay in the US, discrimination, and the extent of socialization with American students were also found to be significant predictors of homesickness. For American students, the number of siblings and financial aid emerged as the major factors with a negative effect on homesickness. (Contains 3 tables.)

Published
2010

162. Migraine and Adverse Pregnancy Outcomes: the nuMoM2b Study (P5-2.006)

Author

Mammadli, Gular, primary, Miller, Eliza, additional, Vollbracht, Sarah, additional, Booker, Whitney, additional, Moroz, Leslie, additional, Gyamfi-Bannerman, Cynthia, additional, Yugrakh, Marianna S., additional, Haas, David M., additional, D’alton, Mary, additional, Wapner, Ronald, additional, Bello, Natalie A., additional, Chau, Kristi, additional, Grobman, William A., additional, and Levine, Lisa D., additional

Published
2022
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164. Cardiomyopathy During A Partial Molar Pregnancy

Author

Cao, Yulei, primary, Zhang, Robert S., additional, Chen, Jessica H., additional, Acker, Andrew M., additional, Chellappa, Deepa K., additional, Heyward, Quetrell D., additional, Janssen, Matthew, additional, McCauley, Brian D., additional, Levine, Lisa D., additional, and Musunuru, Kiran, additional

Published
2022
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166. Telehealth and Children with Disabilities

Author

Waldman, H. Barry, Levine, Lisa Bard, Schwartz, Andrew G., Rader, Rick, and Perlman, Steven P.

Subjects
Telemedicine -- Methods, Caregivers -- Technology application, Intellectual disability services -- Technology application, Mentally disabled children -- Care and treatment, Technology application, Consumer news and advice, Education, Family and marriage, Health
Abstract

'Persons with severe functional disabilities are the highest users of health care services. Care for the needs of this population represents a significant percentage of our national health care costs. [...]

Published
2018

171. Abstract 073: A Mediterranean Diet Pattern Is Associated With Lower Risk Of Adverse Pregnancy Outcomes In US Women: Results From The NuMoM2b Cohort

Author

Makarem, Nour, primary, Chau, Kristi, additional, Miller, Eliza C, additional, Gyamfi-Bannerman, Cynthia, additional, Tous, Isabella, additional, Booker, Whitney A, additional, Catov, Janet M, additional, Haas, David, additional, GROBMAN, William, additional, Levine, Lisa, additional, McNeil, Rebecca, additional, Merz, Noel N, additional, Reddy, Uma, additional, Wapner, Ron, additional, Wong, Melissa, additional, and Bello, Natalie A, additional

Published
2022
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191. Identifying the effective components of a standardized labor induction protocol: secondary analysis of a randomized, controlled trial.

Author

Hamm, Rebecca F., Beidas, Rinad, Srinivas, Sindhu K., and Levine, Lisa D.

Subjects
INDUCED labor (Obstetrics), SECONDARY analysis, CESAREAN section, BIVARIATE analysis, BODY mass index
Abstract

Objective: Standardized labor induction protocols utilizing evidence-based active management practices are associated with improved obstetric outcomes. However, these protocols are complex and include multiple components. We aimed to identify which of the individual components of an evidence-based labor induction protocol are most associated with reduced rates of cesarean delivery, maternal morbidity, and neonatal morbidity. Study Design: This is a secondary analysis of a randomized trial comparing time to delivery among four labor induction methods. All patients enrolled in the trial had their labor managed with a multidisciplinary-developed, evidence-based standardized labor induction protocol. For each patient’s induction, we assessed adherence to seven components of the protocol. Primary outcomes included cesarean delivery, maternal morbidity, and neonatal morbidity. Bivariate analyses assessed the association of each protocol component with each outcome. Multivariable logistic regression determined independent predictors of each outcome. Results: The 491 patients enrolled in the randomized trial were included in this analysis. For cesarean delivery, while adherence to four of the seven protocol components was associated with the outcome in bivariate analyses, only adherence to “cervical exams should be performed every 1–2 h in active labor” was associated with reduced cesarean rates when controlling for age, body mass index, and parity. For maternal morbidity, while adherence to “if misoprostol is utilized, it should not be continued beyond 6 doses or 24 h of use” was associated in bivariate analysis, it was no longer associated with the outcome in multivariable analysis. Finally, “cervical exams should be performed every 1–2 h in active labor” and “cervical exams should be performed every 2–4 h in latent labor” were associated with reduced neonatal morbidity both in bivariate analyses as well as when controlling for age, body mass index, and parity. Conclusions: Within a standardized labor induction protocol, adherence to cervical exams every 1–2 h in active labor was associated with reduced cesarean rate, and adherence to cervical exams every 2–4 h in latent labor, as well as every 1–2 h in active labor is associated with reduced neonatal morbidity. Regular cervical examination during labor induction likely allows for intervention when cervical change is not made. This data warrants further investigation into the optimal frequency of cervical exams during labor induction. Furthermore, an understanding of which components of a complex, evidence-based labor induction protocol are most effective may be helpful for streamlining and education around this protocol as implementation occurs across diverse sites. [ABSTRACT FROM AUTHOR]

Published
2022
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194. Contributors

Author

Abella, Benjamin S., primary, Aberra, Faten N., additional, Adeseun, Gbemisola A., additional, Ahmad, Nuzhat A., additional, Allen, Steven R., additional, Ali, Zarina S., additional, Atluri, Pavan, additional, Ball, Amanda M., additional, Balu, Ramani, additional, Banerjee, Audreesh, additional, Becker, Danielle A., additional, Bellamy, Cassandra J., additional, Berns, Jeffrey S., additional, Bird, Shawn J., additional, Blaya, Marcelo, additional, Bleicher, Melissa B., additional, Bowens, Nina M., additional, Brainard, Jason C., additional, Braslow, Benjamin, additional, Callans, David, additional, Carr-Lettieri, Megan E., additional, Cereda, Maurizio, additional, Chatterjee, Pia, additional, Chen, H. Isaac, additional, Cohen, Debbie L., additional, Cohen, Jeffrey E., additional, Criner, Gerald J., additional, Deitz, Joel, additional, DeLisser, Horace M., additional, Deutschman, Clifford S., additional, Diamond, Joshua, additional, Dibble, Christopher T., additional, Dolan, Jennifer M., additional, Dostal, Courtney L., additional, Ely, E. Wesley, additional, Faigel, Douglas O., additional, Ferrari, Victor A., additional, Fields, Barry, additional, Fishman, Neil, additional, Frank, Ian, additional, Frazer, Michael J., additional, Freese, Andrew, additional, Fried, David A., additional, Fuchs, Barry D., additional, Fuhrman, Steven A., additional, Gazourian, Lee, additional, Glickman, Joel D., additional, Gluckman, Stephen J., additional, Goldberg, Andrew N., additional, Goldberg, Lee R., additional, Goldfarb, Stanley, additional, Goodman, Diane, additional, Gottlieb, Jonathan E., additional, Gracias, Vicente H., additional, Grippi, Michael A., additional, Gurubhagavatula, Indira, additional, Haas, Andrew R., additional, Hamilton, Keith, additional, William Hansen, C., additional, Hermann, Robin, additional, Hess, John R., additional, Hoff, Kolin, additional, Hoke, Linda, additional, Holena, Daniel N., additional, Hudock, Kristin, additional, Isakow, Warren, additional, Janz, David R., additional, Jassar, Arminder, additional, Judy, Kevin D., additional, Kahn, Marc J., additional, Kadakia, Mitul B., additional, Kapa, Suraj, additional, Kasner, Scott E., additional, Kayser, Joshua B., additional, Keeney, Scott A., additional, Kim, Patrick K., additional, Kim, Stephen, additional, King, Rhonda S., additional, Kirkwood, Melissa L., additional, Kobrin, Sidney M., additional, Kohl, Benjamin A., additional, Kolansky, Daniel M., additional, Kotapka, Mark J., additional, Kovach, Stephen J., additional, Kreider, Maryl, additional, Krok, Karen L., additional, Kruse-Jarres, Rebecca, additional, Kucharczuk, John C., additional, Landsburg, Daniel J., additional, Lane-Fall, Meghan B., additional, Lanken, Paul N., additional, Leary, Marion, additional, Levine, David N., additional, Levine, Joshua M., additional, Levine, Lisa D., additional, Lichtenstein, Gary R., additional, Lilly, Craig M., additional, Lilly, Scott M., additional, Loren, Alison W., additional, Low, David W., additional, Maguire, Cheryl, additional, Maki, Junsuke, additional, Malloy, Kelly M., additional, Malone, Daniel, additional, Malosky, Stephen A., additional, Manaker, Scott, additional, Mannes, Andrew, additional, Marchlinski, Francis E., additional, Marcotte, Paul, additional, Masangkay, Neil M., additional, Mascitti, Kara B., additional, McCarthy, Fenton, additional, McGarvey, Michael L., additional, Mechem, C. Crawford, additional, Mehta, Samir, additional, Menard-Katcher, Paul, additional, Meyer, Nuala J., additional, Mikkelsen, Mark E., additional, Milas, Bonnie L., additional, Mirza, Natasha, additional, Moon, Edmund K., additional, Myers, Jennifer S., additional, Netzer, Giora, additional, Nold, Christopher, additional, O’Doherty, Una, additional, Oxman, David A., additional, Paget-Brown, Alix O., additional, Palevsky, Harold I., additional, Panettieri, Reynold A., additional, Parry, Samuel, additional, Pascual, Jose L., additional, Patel, Nirav P., additional, Pechet, Taine T.V., additional, Perrone, Jeanmarie, additional, Phillips, Matthew F., additional, Polk, Travis M., additional, Preston, Ave Maria, additional, Reed, Amy J., additional, Reilly, Eugene F., additional, Reilly, James B., additional, Reilly, John P., additional, Reilly, Patrick M., additional, Ries, Michael, additional, Rosen, Ilene M., additional, Rosenbach, Misha, additional, Rudnick, Michael R., additional, Samadani, Uzma, additional, Sarani, Babak, additional, Sareli, Aharon, additional, Satti, Aditi, additional, Schwab, Richard J., additional, Schweickert, William, additional, Scott, Benjamin K., additional, Segal, Miriam, additional, Shafi, Bilal, additional, Shah, Chirag V., additional, Shah, Siddharth P., additional, Shashaty, Michael G., additional, Shiroff, Adam M., additional, Siegel, Don L., additional, Silvestry, Frank E., additional, Simonian, Melissa A., additional, Sims, Carrie A., additional, Sims, Michael W., additional, Sinkin, Robert A., additional, Soisson, Michael J., additional, Souder, Jeremy, additional, Sunwoo, Bernie, additional, Supple, Gregory E., additional, Takach, Patricia, additional, Talati, Naasha, additional, Tariq, Nabil, additional, Thaler, Erica R., additional, Theodore, Arthur C., additional, Tobias, Mitchell D., additional, Townsend, Raymond R., additional, Turowski, Jason B., additional, Uritsky, Tanya J., additional, Vorovich, Esther, additional, Wade, Alisha N., additional, Washington, Alexander W., additional, Wasserstein, Alan G., additional, Weinhouse, Gerald L., additional, Wilck, Marissa B., additional, Williams, Noel N., additional, Wilson, F. Perry, additional, Wilson, Kevin C., additional, Wolfe, Laura, additional, Woo, Edward Y., additional, Zager, Eric L., additional, and Zhou, Ting, additional

Published
2014
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196. Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy

Author

Goli, Rahul, Li, Jian, Brandimarto, Jeff, Levine, Lisa D., Riis, Valerie, McAfee, Quentin, Depalma, Steven, Haghighi, Alireza, Seidman, J. G., Seidman, Christine E., Jacoby, Daniel, Macones, George, Judge, Daniel P., Rana, Sarosh, Margulies, Kenneth B., Cappola, Thomas P., Alharethi, Rami, Damp, Julie, Hsich, Eileen, Elkayam, Uri, Sheppard, Richard, Alexis, Jeffrey D., Boehmer, John, Kamiya, Chizuko, Gustafsson, Finn, Damm, Peter, Ersbøll, Anne S., Goland, Sorel, Hilfiker-Kleiner, Denise, McNamara, Dennis M., Arany, Zolt, Goli, Rahul, Li, Jian, Brandimarto, Jeff, Levine, Lisa D., Riis, Valerie, McAfee, Quentin, Depalma, Steven, Haghighi, Alireza, Seidman, J. G., Seidman, Christine E., Jacoby, Daniel, Macones, George, Judge, Daniel P., Rana, Sarosh, Margulies, Kenneth B., Cappola, Thomas P., Alharethi, Rami, Damp, Julie, Hsich, Eileen, Elkayam, Uri, Sheppard, Richard, Alexis, Jeffrey D., Boehmer, John, Kamiya, Chizuko, Gustafsson, Finn, Damm, Peter, Ersbøll, Anne S., Goland, Sorel, Hilfiker-Kleiner, Denise, McNamara, Dennis M., and Arany, Zolt

Abstract

Background: Peripartum cardiomyopathy (PPCM) occurs in ≈1:2000 deliveries in the United States and worldwide. The genetic underpinnings of PPCM remain poorly defined. Approximately 10% of women with PPCM harbor truncating variants in TTN (TTNtvs). Whether mutations in other genes can predispose to PPCM is not known. It is also not known if the presence of TTNtvs predicts clinical presentation or outcomes. Nor is it known if the prevalence of TTNtvs differs in women with PPCM and preeclampsia, the strongest risk factor for PPCM. Methods: Women with PPCM were retrospectively identified from several US and international academic centers, and clinical information and DNA samples were acquired. Next-generation sequencing was performed on 67 genes, including TTN, and evaluated for burden of truncating and missense variants. The impact of TTNtvs on the severity of clinical presentation, and on clinical outcomes, was evaluated. Results: Four hundred sixty-nine women met inclusion criteria. Of the women with PPCM, 10.4% bore TTNtvs (odds ratio=9.4 compared with 1.2% in the reference population; Bonferroni-corrected P [P∗]=1.2×10-46). We additionally identified overrepresentation of truncating variants in FLNC (odds ratio=24.8, P∗=7.0×10-8), DSP (odds ratio=14.9, P∗=1.0×10-8), and BAG3 (odds ratio=53.1, P∗=0.02), genes not previously associated with PPCM. This profile is highly similar to that found in nonischemic dilated cardiomyopathy. Women with TTNtvs had lower left ventricular ejection fraction on presentation than did women without TTNtvs (23.5% versus 29%, P=2.5×10-4), but did not differ significantly in timing of presentation after delivery, in prevalence of preeclampsia, or in rates of clinical recovery. Conclusions: This study provides the first extensive genetic and phenotypic landscape of PPCM and demonstrates that predisposition to heart failure is an important risk factor for PPCM. The work reveals a degree of genet

Published
2021

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