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1,307 results on '"Levin, Edward D."'

151. Data from: Cannabinoid exposure and altered DNA methylation in rat and human sperm

Author

Acharya, Kelly, primary, Mitchell, John T., primary, Visco, Zachary, primary, Grenier, Carole, primary, Murphy, Susan K., primary, Schrott, Rose, primary, Hall, Brandon J., primary, Price, Thomas M., primary, McClernon, Joseph, primary, Levin, Edward D., primary, Corcoran, David L., primary, Lucas, Joseph E., primary, Itchon-Ramos, Nilda, primary, Cauley, Marty, primary, Raburn, Douglas J., primary, Kollins, Scott H., primary, Boudreau, Marie-Helene, primary, and Huang, Zhiqing, primary

Published
2020
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156. Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats

Author

Willette, Blair K.A., primary, Nangia, Anica, additional, Howard, Sarah, additional, DiPalma, Devon, additional, McMillan, Collin, additional, Tharwani, Sonum, additional, Evans, Janequia, additional, Wells, Corinne, additional, Slade, Susan, additional, Hall, Brandon J., additional, Rezvani, Amir H., additional, and Levin, Edward D., additional

Published
2019
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174. Crumbling infrastructure and learning impairment: a call for responsibility

Author

Levin, Edward D.

Subjects
Cognitive disorders -- Research -- Risk factors, Children -- Research -- Health aspects, Lead (Metal) -- Research -- Health aspects -- Environmental aspects, Environmental issues, Health
Abstract

We have known for many decades that lead exposure in children causes long-lasting cognitive dysfunction (Byers and Lord 1943; McKhann 1932). A great number of basic and human health studies [...]

Published
2016
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175. Corrigendum to 'The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene: Effects on Cholinergic and Serotonergic Systems'

Author

Slotkin, Theodore A, Skavicus, Samantha, Ko, Ashley, Levin, Edward D, and Seidler, Frederic J

Subjects
Male, Nicotine, Nicotine and Benzo[apyrene] Mimic Development Neurotoxicity of Tobacco Smoke, Brain, Drug Synergism, Toxicology, Corrigenda, Cigarette Smoking, Rats, Sprague-Dawley, Pregnancy, Prenatal Exposure Delayed Effects, Receptors, Serotonin, Benzo(a)pyrene, polycyclic compounds, Animals, Female, Receptors, Cholinergic
Abstract

Tobacco smoke contains polycyclic aromatic hydrocarbons (PAHs) in addition to nicotine. We compared the developmental neurotoxicity of nicotine to that of the PAH archetype, benzo[a]pyrene (BaP), and also evaluated the effects of combined exposure to assess whether PAHs might exacerbate the adverse effects of nicotine. Pregnant rats were treated preconception through the first postnatal week, modeling nicotine concentrations in smokers and a low BaP dose devoid of systemic effects. We conducted evaluations of acetylcholine (ACh) and serotonin (5-hydroxytryptamine, 5HT) systems in brain regions from adolescence through full adulthood. Nicotine or BaP alone impaired indices of ACh presynaptic activity, accompanied by upregulation of nicotinic ACh receptors and 5HT receptors. Combined treatment elicited a greater deficit in ACh presynaptic activity than that seen with either agent alone, and upregulation of nAChRs and 5HT receptors was impaired or absent. The individual effects of nicotine and BaP accounted for only 60% of the combination effects, which thus displayed unique properties. Importantly, the combined nicotine + BaP exposure recapitulated the effects of tobacco smoke, distinct from nicotine. Our results show that the effects of nicotine on development of ACh and 5HT systems are worsened by BaP coexposure, and that combination of the two agents contributes to the greater impact of tobacco smoke on the developing brain. These results have important implications for the relative safety in pregnancy of nicotine-containing products compared with combusted tobacco, both for active maternal smoking and secondhand exposure, and for the effects of such agents in "dirty" environments with high PAH coexposure.

Published
2019

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