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151. Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform

Author

Avet, Charlotte, primary, Mancini, Arturo, additional, Breton, Billy, additional, Le Gouill, Christian, additional, Hauser, Alexander, additional, Normand, Claire, additional, Kobayashi, Hiroyuki, additional, Gross, Florence, additional, Hogue, Mireille, additional, Lukasheva, Viktoriya, additional, Morissette, Sandra, additional, Fauman, Eric, additional, Fortin, Jean-Philippe, additional, Schann, Stéphane, additional, Leroy, Xavier, additional, Gloriam, David E., additional, and Bouvier, Michel, additional

Published
2020
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154. À la recherche du logiciel parfait

Author

Leroy, Xavier and Leroy, Xavier

Subjects
[INFO.INFO-LO] Computer Science [cs]/Logic in Computer Science [cs.LO], ComputingMilieux_MISCELLANEOUS, [INFO.INFO-PL] Computer Science [cs]/Programming Languages [cs.PL]
Published
2018

161. Formal Verification of an Optimizing Compiler

Author

Leroy, Xavier, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Baader, Franz, editor

Published
2007
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168. The CompCert C verified compiler: Documentation and user’s manual: Version 3.6

Author

Leroy, Xavier, Langages de programmation : systèmes de types, concurrence, preuve de programme (CAMBIUM), Collège de France (CdF (institution))-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and Inria

Subjects
[INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL], ComputingMilieux_THECOMPUTINGPROFESSION, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS
Abstract

This document is the user’s manual for the CompCert C verified compiler. It is organized as follows: Chapter 1 gives an overview of the CompCert C compiler and of the formal verification of compilers. Chapter 2 explains how to install CompCert C. Chapter 3 explains how to use the CompCert C compiler. Chapter 4 explains how to use the CompCert C reference interpreter. Chapter 5 describes the subset of the ISO C99 language that is implemented by CompCert. Chapter 6 describes the supported language extensions: pragmas, attributes, built-in functions.

Published
2019

169. The OCaml system release 4.09: Documentation and user's manual

Author

Leroy, Xavier, Doligez, Damien, Frisch, Alain, Garrigue, Jacques, Rémy, Didier, Vouillon, Jérôme, Langages de programmation : systèmes de types, concurrence, preuve de programme (CAMBIUM), Collège de France (CdF (institution))-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), LexiFi [Boulogne-Billancourt], Graduate School of Mathematics [Nagoya], Nagoya University, Institut de Recherche en Informatique Fondamentale (IRIF (UMR_8243)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Inria, and Collège de France (CdF)-Inria de Paris

Subjects
[INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL], TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION, Software_PROGRAMMINGTECHNIQUES, Software_PROGRAMMINGLANGUAGES
Abstract

This manual documents the release 4.09 of the OCaml system. It is organized as follows. Part I, "An introduction to OCaml", gives an overview of the language. Part II, "The OCaml language", is the reference description of the language. Part III, "The OCaml tools", documents the compilers, toplevel system, and programming utilities. Part IV, "The OCaml library", describes the modules provided in the standard library.

Published
2019

176. Testicular natural killer T-cell lymphoma

Author

BALLEREAU, CHARLES, LEROY, XAVIER, MORSCHHAUSER, FRANCK, FANTONI, JEAN-CHRISTOPHE, LEMAITRE, LAURENT, VILLERS, ARNAULD, and BISERTE, JACQUES

Published
2005

183. Embedded Program Annotations for WCET Analysis

Author

Schommer, Bernhard, Cullmann, Christoph, Gebhard, Gernot, Leroy, Xavier, Schmidt, Michael, Wegener, Simon, Saarland University [Saarbrücken], AbsInt GmbH (Angewandte Informatik), AbsInt, Langages de programmation, types, compilation et preuves (GALLIUM), Inria de Paris, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)

Subjects
000 Computer science, knowledge, general works, [INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL], Computer Science, [INFO.INFO-ES]Computer Science [cs]/Embedded Systems
Abstract

International audience; We present __builtin_ais_annot(), a user-friendly, versatile way to transfer annotations (also known as flow facts) written on the source code level to the machine code level. To do so, we couple two tools often used during the development of safety-critical hard real-time systems, the formally verified C compiler CompCert and the static WCET analyzer aiT. CompCert stores the AIS annotations given via __builtin_ais_annot() in a special section of the ELF binary, which can later be extracted automatically by aiT.

Published
2018

184. CompCert: Practical Experience on Integrating and Qualifying a Formally Verified Optimizing Compiler

Author

Kästner, Daniel, Barrho, Jörg, Wünsche, Ulrich, Schlickling, Marc, Schommer, Bernhard, Schmidt, Michael, Ferdinand, Christian, Leroy, Xavier, Blazy, Sandrine, AbsInt GmbH (Angewandte Informatik), AbsInt, MTU Friedrichshafen GmbH, Saarland University [Saarbrücken], Langages de programmation, types, compilation et preuves (GALLIUM), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Software certification with semantic analysis (CELTIQUE), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-LANGAGE ET GÉNIE LOGICIEL (IRISA-D4), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), 3AF, SEE, SIE, Langages de programmation : systèmes de types, concurrence, preuve de programme (CAMBIUM), Collège de France (CdF (institution))-Inria de Paris, Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1)

Subjects
[INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL], TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO]
Abstract

International audience; CompCert is the first commercially available optimizing compiler that is formally verified, using machine-assisted mathematical proofs, to be exempt from mis-compilation. The executable code it produces is proved to behave exactly as specified by the semantics of the source C program. This article gives an overview of the use of CompCert to gain certification credits for a highly safety-critical industry application, certified according to IEC 60880. We will briefly introduce the target application, illustrate the process of changing the existing compiler infrastructure to CompCert, and discuss performance characteristics. The main part focuses on the tool qualification strategy, in particular on how to take advantage of the formal correctness proof in the certification process.

Published
2018

186. Abstract 3278: EOS100850 potently restores adenosine A2Areceptor-dependent suppression of T cell function in the adenosine rich tumor microenvironment

Author

Houthuys, Erica, primary, Basilico, Paola, additional, Bodo, Veronique, additional, Brouwer, Margreet, additional, Detheux, Michel, additional, Driessens, Gregory, additional, Gomes, Bruno, additional, Hermant, Annelise, additional, Hoofd, Catherine, additional, Lambolez, Florence, additional, Leroy, Xavier, additional, Marillier, Reece, additional, Martinoli, Chiara, additional, Mercier, Marjorie, additional, Nyawouame, Florence, additional, Prasad, Shruthi, additional, Scoumanne, Ariane, additional, and Crosignani, Stefano, additional

Published
2019
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187. Abstract 3261: EOS100850, a non-brain penetrant highly selective A2Areceptor antagonist, uniquely maintains high potency within the adenosine rich tumor microenvironment

Author

Houthuys, Erica, primary, Basilico, Paola, additional, Brouwer, Margreet, additional, Deregnaucourt, Theo, additional, Detheux, Michel, additional, Driessens, Gregory, additional, Gomes, Bruno, additional, Leroy, Xavier, additional, Marchante, Joao, additional, Marillier, Reece, additional, Swiercz, Jakub, additional, and Crosignani, Stefano, additional

Published
2019
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188. Abstract 4147: EOS100850, an A2Areceptor antagonist with prolonged pharmacodynamic activity, mediates the generation ofspecific durable immune responses in a murine breast cancer model

Author

Pirson, Romain, primary, Michaux, Anne-Catherine, additional, Jamart, Diane, additional, Preillon, Julie, additional, Frederix, Kim, additional, Basilico, Paola, additional, Martinoli, Chiara, additional, Leroy, Xavier, additional, Driessens, Gregory, additional, Houthuys, Erica, additional, Chappel, Scott, additional, Crosignani, Stefano, additional, and Marillier, Reece, additional

Published
2019
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189. TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases

Author

Delliaux, Carine, primary, Tian, Tian V., additional, Bouchet, Mathilde, additional, Fradet, Anais, additional, Vanpouille, Nathalie, additional, Flourens, Anne, additional, Deplus, Rachel, additional, Villers, Arnauld, additional, Leroy, Xavier, additional, Clézardin, Philippe, additional, de Launoit, Yvan, additional, Bonnelye, Edith, additional, and Duterque-Coquillaud, Martine, additional

Published
2018
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195. CompCert - A Formally Verified Optimizing Compiler

Author

Leroy, Xavier, Blazy, Sandrine, Kästner, Daniel, Schommer, Bernhard, Pister, Markus, Ferdinand, Christian, Langages de programmation, types, compilation et preuves (GALLIUM), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Software certification with semantic analysis (CELTIQUE), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-LANGAGE ET GÉNIE LOGICIEL (IRISA-D4), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), AbsInt GmbH (Angewandte Informatik), AbsInt, SEE, ANR-11-INSE-0003,VERASCO,Vérification formelle d'analyseurs statiques et de compilateurs(2011), LANGAGE ET GÉNIE LOGICIEL (IRISA-D4), CentraleSupélec-Télécom Bretagne-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Télécom Bretagne-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Leroy, Xavier, and Ingénierie Numérique et Sécurité - Vérification formelle d'analyseurs statiques et de compilateurs - - VERASCO2011 - ANR-11-INSE-0003 - INS - VALID

Subjects
[INFO.INFO-LO] Computer Science [cs]/Logic in Computer Science [cs.LO], [INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL], TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], [INFO.INFO-PL] Computer Science [cs]/Programming Languages [cs.PL]
Abstract

International audience; CompCert is the first commercially available optimizing compiler that is formally verified, using machine-assisted mathematical proofs, to be exempt from mis-compilation. The executable code it produces is proved to behave exactly as specified by the semantics of the source C program. This article gives an overview of the design of CompCert and its proof concept and then focuses on aspects relevant for industrial application. We briefly summarize practical experience and give an overview of recent CompCert development aiming at industrial usage. CompCert's intended use is the compilation of life-critical and mission-critical software meeting high levels of assurance. In this context tool qualification is of paramount importance. We summarize the confidence argument of CompCert and give an overview of relevant qualification strategies.

Published
2016

197. Embedded Program Annotations for WCET Analysis

Author

Bernhard Schommer and Christoph Cullmann and Gernot Gebhard and Xavier Leroy and Michael Schmidt and Simon Wegener, Schommer, Bernhard, Cullmann, Christoph, Gebhard, Gernot, Leroy, Xavier, Schmidt, Michael, Wegener, Simon, Bernhard Schommer and Christoph Cullmann and Gernot Gebhard and Xavier Leroy and Michael Schmidt and Simon Wegener, Schommer, Bernhard, Cullmann, Christoph, Gebhard, Gernot, Leroy, Xavier, Schmidt, Michael, and Wegener, Simon

Abstract

We present __builtin_ais_annot(), a user-friendly, versatile way to transfer annotations (also known as flow facts) written on the source code level to the machine code level. To do so, we couple two tools often used during the development of safety-critical hard real-time systems, the formally verified C compiler CompCert and the static WCET analyzer aiT. CompCert stores the AIS annotations given via __builtin_ais_annot() in a special section of the ELF binary, which can later be extracted automatically by aiT.

Published
2018
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198. Adolf Hitler : The Emergence of Nazism

Author

Leroy, Xavier, Jacquemin, Thomas, 50Minutes.com, Leroy, Xavier, Leroy, Xavier, Jacquemin, Thomas, 50Minutes.com, and Leroy, Xavier

Abstract

Keen to learn but short on time? Get to grips with the life of Adolf Hitler in next to no time with this concise guide.50Minutes.com provides a clear and engaging analysis of Adolf Hitler. Adolf Hitler’s name will never be forgotten and his atrocious acts are still remembered to this day. He led the most shocking crimes against humanity in modern history which saw millions of people, particularly Jews, killed. But when Hitler was a child, there was no indication that he would grow up to be this figure of hate. So how did this passionate artist become the man responsible for the 20th century’s biggest genocide?In just 50 minutes you will: • Learn about Hitler’s life from his average childhood in Austria to his suicide in Berlin • Understand how he came to form the Nazi Party and terrorise Europe, invading countries and leaving a trail of destruction in his wake • Analyse the developments that took place across the world as a result of Hitler’s actions, such as the creation of the United Nations and the start of the Cold WarABOUT 50MINUTES.COM | History & Culture50MINUTES.COM will enable you to quickly understand the main events, people, conflicts and discoveries from world history that have shaped the world we live in today. Our publications present the key information on a wide variety of topics in a quick and accessible way that is guaranteed to save you time on your journey of discovery.

Published
2015

199. Adolf Hitler : Le dictateur à l'origine de la folie nazie

Author

Leroy, Xavier, Jacquemin, Thomas, 50Minutes.fr, Leroy, Xavier, Leroy, Xavier, Jacquemin, Thomas, 50Minutes.fr, and Leroy, Xavier

Abstract

Découvrez enfin tout ce qu’il faut savoir sur Adolf Hitler en moins d’une heure !Artiste raté, ancien clochard et survivant des tranchées, Adolf Hitler est devenu le tyran le plus terrible que l’Europe ait connu, alors même que rien ne le laissait présager... Né en Autriche, il connaît une jeunesse faite de frustrations et d’échecs. La Première Guerre mondiale lui donne une cause à défendre, et c’est à corps perdu qu’il se dévoue à l’Allemagne. Mais l’humiliation qu’elle subit le laisse profondément amer et le conforte dans l’idée que la nation qu’il admire tant a été trahie par des ennemis intérieurs : les juifs et les communistes. Il n’a dès lors plus qu’une idée en tête : prendre la tête du pays pour restaurer sa puissance et imposer à l’Europe entière la suprématie de la race aryenne, qu'elles qu'en soient les conséquences. Un monstre est né.Ce livre vous permettra d’en savoir plus sur : • La vie d’Hitler • Le contexte de l’époque • Les temps forts de la vie du Führer • Les conséquences de son actionLe mot de l’éditeur :« Dans ce numéro de la collection 50MINUTES Grandes Personnalités, Xavier Leroy dresse pour nous le portrait de l’une des personnalités les plus controversées du XXe siècle, Adolf Hitler. Si tout le monde connaît aujourd’hui sa responsabilité dans le déclenchement de la Seconde Guerre mondiale et le massacre des juifs, l’homme reste encore largement insaisissable. C’est pourquoi l’auteur tente de lever une partie du voile et nous laisse entrevoir la naissance du mal. » Stéphanie DagrainÀ PROPOS DE LA SÉRIE 50MINUTES | Grandes PersonnalitésLa série Grandes Personnalités de la collection « 50MINUTES » présente plus de cinquante hommes et femmes qui ont marqué l’histoire d’une manière ou d’une autre. Chaque livre a été pensé pour les lecteurs curieux qui veulent faire le tour d’un sujet précis, tout en allant à l’essentiel, et ce en moins d’une heure. Nos auteurs combinent les faits historiques, les analyses et les nouvelles perspectives pou

Published
2015

200. Chronic pneumonia with Pseudomonas aeruginosa and impaired alveolar fluid clearance

Author

Prangere Thierry, Kipnis Eric, Husson Marie, Ader Florence, Faure Karine, Boyer Sophie, Leroy Xavier, and Guery Benoit P

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background While the functional consequences of acute pulmonary infections are widely documented, few studies focused on chronic pneumonia. We evaluated the consequences of chronic Pseudomonas lung infection on alveolar function. Methods P. aeruginosa, included in agar beads, was instilled intratracheally in Sprague Dawley rats. Analysis was performed from day 2 to 21, a control group received only sterile agar beads. Alveolar-capillary barrier permeability, lung liquid clearance (LLC) and distal alveolar fluid clearance (DAFC) were measured using a vascular (131I-Albumin) and an alveolar tracer (125I-Albumin). Results The increase in permeability and LLC peaked on the second day, to return to baseline on the fifth. DAFC increased independently of TNF-α or endogenous catecholamine production. Despite the persistence of the pathogen within the alveoli, DAFC returned to baseline on the 5th day. Stimulation with terbutaline failed to increase DAFC. Eradication of the pathogen with ceftazidime did not restore DAFC response. Conclusions From these results, we observe an adequate initial alveolar response to increased permeability with an increase of DAFC. However, DAFC increase does not persist after the 5th day and remains unresponsive to stimulation. This impairment of DAFC may partly explain the higher susceptibility of chronically infected patients to subsequent lung injury.

Published
2005
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