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151. Measurement of coherent vibrational dynamics with X-ray Transient Absorption Spectroscopy simultaneously at the Carbon K- and Chlorine L2,3- edges

Author: Andrew D. Ross, Diptarka Hait, Valeriu Scutelnic, Daniel M. Neumark, Martin Head-Gordon, and Stephen R. Leone
Subjects: Astrophysics, QB460-466, Physics, QC1-999
Abstract: Abstract X-ray Transient Absorption Spectroscopy (XTAS) is a powerful probe for ultrafast molecular dynamics. The evolution of XTAS signal is controlled by the shapes of potential energy surfaces of the associated core-excited states, which are difficult to directly measure. Here, we study the vibrational dynamics of Raman activated CCl4 with XTAS targeting the C 1s and Cl 2p electrons. The totally symmetric stretching mode leads to concerted elongation or contraction in bond lengths, which in turn induce an experimentally measurable red or blue shift in the X-ray absorption energies associated with inner-shell electron excitations to the valence antibonding levels. The ratios between slopes of different core-excited potential energy surfaces (CEPESs) thereby extracted agree very well with Restricted Open-Shell Kohn-Sham calculations. The other, asymmetric, modes do not measurably contribute to the XTAS signal. The results highlight the ability of XTAS to reveal coherent nuclear dynamics involving
Published: 2024
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152. Clinical significance of postoperative thrombocytosis after vats lobectomy for NSCLC

Author: Beatrice Leonardi, Giovanni Natale, Salvatore Ferraioli, Francesco Leone, Mario Grande, Maria Antonietta Puca, Anna Rainone, Gaetana Messina, Antonello Sica, and Alfonso Fiorelli
Subjects: Lobectomy, Thrombocytosis, Lung cancer, Thoracoscopy, Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract: Abstract Objectives Thrombocytosis is a clinical condition generally associated with poor prognosis in patients with cancer. Thrombocytosis may be present after lung cancer resection, but the clinical significance of thrombocytosis remains unclear. Herein, we evaluated whether postoperative thrombocytosis was a negative prognostic factor in patients undergoing thoracoscopic lobectomy for lung cancer. Methods It was a retrospective monocentric study including consecutive patients undergoing thoracoscopic lobectomy for lung cancer from January 2020 to January 2023. The outcome of patients with postoperative thrombocytosis (defined as platelet count ≥ 450 × 10^9/L at 24 h after the surgery and confirmed at postoperative day 7) was compared with a control group. Postoperative morbidity, mortality, and survival were compared between the two groups to define whether thrombocytosis negatively affected outcomes. Results Our study population included 183 patients; of these, 22 (12%) presented postoperative thrombocytosis: 9 (5%) mild thrombocytosis (451–700 × 10^9/L), 10 (5%) moderate thrombocytosis (701–900 × 10^9/L), and 3 (2%) severe thrombocytosis (901–1000 × 10^9/L). No significant differences were found regarding postoperative morbidity (p = 0.92), mortality (p = 0.53), overall survival (p = 0.45), and disease-free survival (p = 0.60) between the two study groups. Thrombocytosis was associated with higher rate of atelectasis (36% vs. 6%, p
Published: 2024
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153. Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy

Author: Francesca Giammello, Chiara Biella, Erica Cecilia Priori, Matilde Amat Di San Filippo, Roberta Leone, Francesca D’Ambrosio, Martina Paterno’, Giulia Cassioli, Antea Minetti, Francesca Macchi, Cristina Spalletti, Ilaria Morella, Cristina Ruberti, Beatrice Tremonti, Federica Barbieri, Giuseppe Lombardi, Riccardo Brambilla, Tullio Florio, Rossella Galli, Paola Rossi, and Federico Brandalise
Subjects: GBM, Nav, CANCER STEM CELLS, TMZ, TTX, CHEMOTHERAPY, ERK, Medicine, Cytology, QH573-671
Abstract: Abstract Background Glioblastoma (GBM) stands as the most prevalent and aggressive form of adult gliomas. Despite the implementation of intensive therapeutic approaches involving surgery, radiation, and chemotherapy, Glioblastoma Stem Cells contribute to tumor recurrence and poor prognosis. The induction of Glioblastoma Stem Cells differentiation by manipulating the transcriptional machinery has emerged as a promising strategy for GBM treatment. Here, we explored an innovative approach by investigating the role of the depolarized resting membrane potential (RMP) observed in patient-derived GBM sphereforming cell (GSCs), which allows them to maintain a stemness profile when they reside in the G0 phase of the cell cycle. Methods We conducted molecular biology and electrophysiological experiments, both in vitro and in vivo, to examine the functional expression of the voltage-gated sodium channel (Nav) in GSCs, particularly focusing on its cell cycle-dependent functional expression. Nav activity was pharmacologically manipulated, and its effects on GSCs behavior were assessed by live imaging cell cycle analysis, self-renewal assays, and chemosensitivity assays. Mechanistic insights into the role of Nav in regulating GBM stemness were investigated through pathway analysis in vitro and through tumor proliferation assay in vivo. Results We demonstrated that Nav is functionally expressed by GSCs mainly during the G0 phase of the cell cycle, suggesting its pivotal role in modulating the RMP. The pharmacological blockade of Nav made GBM cells more susceptible to temozolomide (TMZ), a standard drug for this type of tumor, by inducing cell cycle re-entry from G0 phase to G1/S transition. Additionally, inhibition of Nav substantially influenced the self-renewal and multipotency features of GSCs, concomitantly enhancing their degree of differentiation. Finally, our data suggested that Nav positively regulates GBM stemness by depolarizing the RMP and suppressing the ERK signaling pathway. Of note, in vivo proliferation assessment confirmed the increased susceptibility to TMZ following pharmacological blockade of Nav. Conclusions This insight positions Nav as a promising prognostic biomarker and therapeutic target for GBM patients, particularly in conjunction with temozolomide treatment.
Published: 2024
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154. Multiomic Profiling and Neuroprotective Bioactivity of Salvia Hairy Root-Derived Extracellular Vesicles in a Cellular Model of Parkinson’s Disease

Author: Vestuto V, Conte M, Vietri M, Mensitieri F, Santoro V, Di Muro A, Alfieri M, Moros M, Miranda MR, Amante C, Delli Carri M, Campiglia P, Dal Piaz F, Del Gaudio P, De Tommasi N, Leone A, Moltedo O, Pepe G, Cappetta E, and Ambrosone A
Subjects: non-mammalian ev source, salvia extracellular vesicles, hairy roots, nanomedicine, neuroprotection, parkinson’s disease, Medicine (General), R5-920
Abstract: Vincenzo Vestuto,1,&ast; Marisa Conte,1,&ast; Mariapia Vietri,1,&ast; Francesca Mensitieri,2 Valentina Santoro,1,3 Anna Di Muro,1 Mariaevelina Alfieri,4 Maria Moros,5,6 Maria Rosaria Miranda,1,3 Chiara Amante,1 Matteo Delli Carri,1 Pietro Campiglia,1 Fabrizio Dal Piaz,2,7 Pasquale Del Gaudio,1 Nunziatina De Tommasi,1,3 Antonietta Leone,1 Ornella Moltedo,1 Giacomo Pepe,1,3 Elisa Cappetta,1 Alfredo Ambrosone1 1Department of Pharmacy, University of Salerno, Fisciano, 84084, Italy; 2Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, 84081, Italy; 3National Biodiversity Future Center (NBFC), Palermo, 90133, Italy; 4Clinical Pathology, Santobono-Pausilipon Children’s Hospital, AORN, Naples, 80122, Italy; 5Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, Spain; 6Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain; 7Operative Unit of Clinical Pharmacology, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, 84131, Italy&ast;These authors contributed equally to this workCorrespondence: Alfredo Ambrosone; Elisa Cappetta, Department of Pharmacy, University of Salerno, Fisciano, 84084, Italy, Email aambrosone@unisa.it; ecappetta@unisa.itPurpose: Extracellular vesicles (EVs) are promising tools for nanomedicine and nanobiotechnology. The purification of mammalian-derived EVs involves intensive processes, and their therapeutic application raises multiple safety and regulatory issues. Plants have the potential to serve as nonconventional sources of therapeutically relevant EVs. In this context, we recently identified hairy roots (HRs) of medicinal plants as a novel biotechnological platform to produce EVs for human health.Methods: Herein, we report the purification, omics profiling, and bioactivity of EVs isolated from HRs of the medicinal plants S. sclarea and S. dominica. EVs were isolated from conditioned media of HR cultures using differential ultracentrifugation (dUC) and size exclusion chromatography (SEC). The isolated EVs were characterized by nanoparticle tracking analysis (NTA) and electron microscopy. The proteomic and metabolomic profiles of the EVs were determined using mass spectrometry. Uptake studies and bioactivity assays, including confocal microscopy, MTT, flow cytometry, ROS quantification, and untargeted metabolomics analyses, were conducted in SH-SY5Y cells treated with the neurotoxin 6-hydroxydopamine (6-OHDA) to evaluate the therapeutic potential of EVs in an in vitro model of Parkinson’s disease.Results: S. sclarea HRs released nanosized round-shaped EVs with a distinctive molecular signature. HR EVs from S. sclarea and S. dominica revealed conserved cargo of secondary metabolites, predominantly triterpenoids, which are known for their antioxidant properties. We showed that HR EVs are safe, enter the cells, and strongly inhibit apoptosis in a cellular model of Parkinson’s disease. Cellular metabolomics revealed that EVs preserved metabolic homeostasis and mitigated cellular oxidative stress when co-administered with 6-OHDA. Mechanistically, HR EVs inhibited 6-OHDA autoxidation and substantially reduced the accumulation of its oxidative products, which are responsible for 6-OHDA-induced toxicity.Conclusion: Collectively, our findings provide compelling evidence that EVs isolated from the hairy roots of Salvia species are promising, non-mammalian alternative for the design of novel therapies targeting neurological disorders. Keywords: non-mammalian EV source, Salvia extracellular vesicles, hairy roots, nanomedicine, neuroprotection, Parkinson’s disease
Published: 2024

155. Search for dark mesons decaying to top and bottom quarks in proton-proton collisions at s $$ \sqrt{\textrm{s}} $$ = 13 TeV with the ATLAS detector

Author: The ATLAS collaboration, G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N. J. Abicht, S. H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adiguzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, N. N. Akolkar, S. Aktas, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, G. L. Albouy, S. Alderweireldt, Z. L. Alegria, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, S. W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. A. Allendes Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z. M. K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. Amidei, B. Amini, K. J. Amirie, S. P. Amor Dos Santos, K. R. Amos, D. Amperiadou, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, A. C. Anderson, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M. A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S. J. Arbiol Val, C. Arcangeletti, A. T. H. Arce, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, R. A. Ashby Pickering, K. Assamagan, R. Astalos, K. S. V. Astrand, S. Atashi, R. J. Atkin, M. Atkinson, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T. M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J. T. Baines, L. Baines, O. K. Baker, E. Bakos, D. Bakshi Gupta, L. E. Balabram Filho, V. Balakrishnan, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, I. Bamwidhi, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, M. Barakat, E. L. Barberio, D. Barberis, M. Barbero, M. Z. Barel, T. Barillari, M-S. Barisits, T. Barklow, P. Baron, D. A. Baron Moreno, A. Baroncelli, A. J. Barr, J. D. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M. J. Basso, S. Bataju, R. Bate, R. L. Bates, S. Batlamous, B. Batool, M. Battaglia, D. Battulga, M. Bauce, M. Bauer, P. Bauer, L. T. Bazzano Hurrell, J. B. Beacham, T. Beau, J. Y. Beaucamp, P. H. Beauchemin, P. Bechtle, H. P. Beck, K. Becker, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, K. C. Benkendorfer, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F. U. Bernlochner, F. Bernon, A. Berrocal Guardia, T. Berry, P. Berta, A. Berthold, S. Bethke, A. Betti, A. J. Bevan, N. K. Bhalla, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, K. D. Bhide, V. S. Bhopatkar, R. M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C. S. Billingsley, Y. Bimgdi, M. Bindi, A. Bingul, C. Bini, G. A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J. P. Biswal, D. Biswas, I. Bloch, A. Blue, U. Blumenschein, J. Blumenthal, V. S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, A. G. Bogdanchikov, L. S. Boggia, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C. D. Booth, A. G. Borbély, I. S. Bordulev, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J. D. Bossio Sola, K. Bouaouda, N. Bouchhar, L. Boudet, J. Boudreau, E. V. Bouhova-Thacker, D. Boumediene, R. Bouquet, A. Boveia, J. Boyd, D. Boye, I. R. Boyko, L. Bozianu, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J. E. Brau, R. Brener, L. Brenner, R. Brenner, S. Bressler, G. Brianti, D. Britton, D. Britzger, I. Brock, G. Brooijmans, E. M. Brooks, E. Brost, L. M. Brown, L. E. Bruce, T. L. Bruckler, P. A. Bruckman de Renstrom, B. Brüers, A. Bruni, G. Bruni, M. Bruschi, N. Bruscino, T. Buanes, Q. Buat, D. Buchin, A. G. Buckley, O. Bulekov, B. A. Bullard, S. Burdin, C. D. Burgard, A. M. Burger, B. Burghgrave, O. Burlayenko, J. Burleson, J. T. P. Burr, J. C. Burzynski, E. L. Busch, V. Büscher, P. J. Bussey, J. M. Butler, C. M. Buttar, J. M. Butterworth, W. Buttinger, C. J. Buxo Vazquez, A. R. Buzykaev, S. Cabrera Urbán, L. Cadamuro, D. Caforio, H. Cai, Y. Cai, V. M. M. Cairo, O. Cakir, N. Calace, P. Calafiura, G. Calderini, P. Calfayan, G. Callea, L. P. Caloba, D. Calvet, S. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, M. T. Camerlingo, D. Cameron, C. Camincher, M. Campanelli, A. Camplani, V. Canale, A. C. Canbay, E. Canonero, J. Cantero, Y. Cao, F. Capocasa, M. Capua, A. Carbone, R. Cardarelli, J. C. J. Cardenas, G. Carducci, T. Carli, G. Carlino, J. I. Carlotto, B. T. Carlson, E. M. Carlson, J. Carmignani, L. Carminati, A. Carnelli, M. Carnesale, S. Caron, E. Carquin, I. B. Carr, S. Carrá, G. Carratta, A. M. Carroll, T. M. Carter, M. P. Casado, M. Caspar, F. L. Castillo, L. Castillo Garcia, V. Castillo Gimenez, N. F. Castro, A. Catinaccio, J. R. Catmore, T. Cavaliere, V. Cavaliere, N. Cavalli, L. J. Caviedes Betancourt, Y. C. Cekmecelioglu, E. Celebi, S. Cella, F. Celli, M. S. Centonze, V. Cepaitis, K. Cerny, A. S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, B. Cervato, A. Cervelli, G. Cesarini, S. A. Cetin, D. Chakraborty, J. Chan, W. Y. Chan, J. D. Chapman, E. Chapon, B. Chargeishvili, D. G. Charlton, M. Chatterjee, C. Chauhan, Y. Che, S. Chekanov, S. V. Chekulaev, G. A. Chelkov, A. Chen, B. Chen, H. Chen, J. Chen, M. Chen, S. Chen, S. J. Chen, X. Chen, Y. Chen, C. L. Cheng, H. C. Cheng, S. Cheong, A. Cheplakov, E. Cheremushkina, E. Cherepanova, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, N. Chiedde, G. Chiodini, A. S. Chisholm, A. Chitan, M. Chitishvili, M. V. Chizhov, K. Choi, Y. Chou, E. Y. S. Chow, K. L. Chu, M. C. Chu, X. Chu, Z. Chubinidze, J. Chudoba, J. J. Chwastowski, D. Cieri, K. M. Ciesla, V. Cindro, A. Ciocio, F. Cirotto, Z. H. Citron, M. Citterio, D. A. Ciubotaru, A. Clark, P. J. Clark, N. Clarke Hall, C. Clarry, J. M. Clavijo Columbie, S. E. Clawson, C. Clement, Y. Coadou, M. Cobal, A. Coccaro, R. F. Coelho Barrue, R. Coelho Lopes De Sa, S. Coelli, B. Cole, J. Collot, P. Conde Muiño, M. P. Connell, S. H. Connell, E. I. Conroy, F. Conventi, H. G. Cooke, A. M. Cooper-Sarkar, F. A. Corchia, A. Cordeiro Oudot Choi, L. D. Corpe, M. Corradi, F. Corriveau, A. Cortes-Gonzalez, M. J. Costa, F. Costanza, D. Costanzo, B. M. Cote, J. Couthures, G. Cowan, K. Cranmer, L. Cremer, D. Cremonini, S. Crépé-Renaudin, F. Crescioli, M. Cristinziani, M. Cristoforetti, V. Croft, J. E. Crosby, G. Crosetti, A. Cueto, H. Cui, Z. Cui, W. R. Cunningham, F. Curcio, J. R. Curran, P. Czodrowski, M. J. Da Cunha Sargedas De Sousa, J. V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, D. Dal Santo, C. Dallapiccola, M. Dam, G. D’amen, V. D’Amico, J. Damp, J. R. Dandoy, D. Dannheim, M. Danninger, V. Dao, G. Darbo, S. J. Das, F. Dattola, S. D’Auria, A. D’avanzo, C. David, T. Davidek, I. Dawson, H. A. Day-hall, K. De, R. De Asmundis, N. De Biase, S. De Castro, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, A. De Salvo, U. De Sanctis, F. De Santis, A. De Santo, J. B. De Vivie De Regie, J. Debevc, D. V. Dedovich, J. Degens, A. M. Deiana, F. Del Corso, J. Del Peso, L. Delagrange, F. Deliot, C. M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell’Acqua, L. Dell’Asta, M. Delmastro, P. A. Delsart, S. Demers, M. Demichev, S. P. Denisov, L. D’Eramo, D. Derendarz, F. Derue, P. Dervan, K. Desch, C. Deutsch, F. A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, A. Di Domenico, C. Di Donato, A. Di Girolamo, G. Di Gregorio, A. Di Luca, B. Di Micco, R. Di Nardo, K. F. Di Petrillo, M. Diamantopoulou, F. A. Dias, T. Dias Do Vale, M. A. Diaz, F. G. Diaz Capriles, A. R. Didenko, M. Didenko, E. B. Diehl, S. Díez Cornell, C. Diez Pardos, C. Dimitriadi, A. Dimitrievska, J. Dingfelder, T. Dingley, I-M. Dinu, S. J. Dittmeier, F. Dittus, M. Divisek, B. Dixit, F. Djama, T. Djobava, C. Doglioni, A. Dohnalova, J. Dolejsi, Z. Dolezal, K. Domijan, K. M. Dona, M. Donadelli, B. Dong, J. Donini, A. D’Onofrio, M. D’Onofrio, J. Dopke, A. Doria, N. Dos Santos Fernandes, P. Dougan, M. T. Dova, A. T. Doyle, M. A. Draguet, E. Dreyer, I. Drivas-koulouris, M. Drnevich, M. Drozdova, D. Du, T. A. du Pree, F. Dubinin, M. Dubovsky, E. Duchovni, G. Duckeck, O. A. Ducu, D. Duda, A. Dudarev, E. R. Duden, M. D’uffizi, L. Duflot, M. Dührssen, I. Duminica, A. E. Dumitriu, M. Dunford, S. Dungs, K. Dunne, A. Duperrin, H. Duran Yildiz, M. Düren, A. Durglishvili, B. L. Dwyer, G. I. Dyckes, M. Dyndal, B. S. Dziedzic, Z. O. Earnshaw, G. H. Eberwein, B. Eckerova, S. Eggebrecht, E. Egidio Purcino De Souza, L. F. Ehrke, G. Eigen, K. Einsweiler, T. Ekelof, P. A. Ekman, S. El Farkh, Y. El Ghazali, H. El Jarrari, A. El Moussaouy, V. Ellajosyula, M. Ellert, F. Ellinghaus, N. Ellis, J. Elmsheuser, M. Elsawy, M. Elsing, D. Emeliyanov, Y. Enari, I. Ene, S. Epari, P. A. Erland, D. Ernani Martins Neto, M. Errenst, M. Escalier, C. Escobar, E. Etzion, G. Evans, H. Evans, L. S. Evans, A. Ezhilov, S. Ezzarqtouni, F. Fabbri, L. Fabbri, G. Facini, V. Fadeyev, R. M. Fakhrutdinov, D. Fakoudis, S. Falciano, L. F. Falda Ulhoa Coelho, F. Fallavollita, G. Falsetti, J. Faltova, C. Fan, K. Y. Fan, Y. Fan, Y. Fang, M. Fanti, M. Faraj, Z. Farazpay, A. Farbin, A. Farilla, T. Farooque, S. M. Farrington, F. Fassi, D. Fassouliotis, M. Faucci Giannelli, W. J. Fawcett, L. Fayard, P. Federic, P. Federicova, O. L. Fedin, M. Feickert, L. Feligioni, D. E. Fellers, C. Feng, Z. Feng, M. J. Fenton, L. Ferencz, R. A. M. Ferguson, S. I. Fernandez Luengo, P. Fernandez Martinez, M. J. V. Fernoux, J. Ferrando, A. Ferrari, P. Ferrari, R. Ferrari, D. Ferrere, C. Ferretti, D. Fiacco, F. Fiedler, P. Fiedler, A. Filipčič, E. K. Filmer, F. Filthaut, M. C. N. Fiolhais, L. Fiorini, W. C. Fisher, T. Fitschen, P. M. Fitzhugh, I. Fleck, P. Fleischmann, T. Flick, M. Flores, L. R. Flores Castillo, L. Flores Sanz De Acedo, F. M. Follega, N. Fomin, J. H. Foo, A. Formica, A. C. Forti, E. Fortin, A. W. Fortman, M. G. Foti, L. Fountas, D. Fournier, H. Fox, P. Francavilla, S. Francescato, S. Franchellucci, M. Franchini, S. Franchino, D. Francis, L. Franco, V. Franco Lima, L. Franconi, M. 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Piacquadio, E. Pianori, F. Piazza, R. Piegaia, D. Pietreanu, A. D. Pilkington, M. Pinamonti, J. L. Pinfold, B. C. Pinheiro Pereira, J. Pinol Bel, A. E. Pinto Pinoargote, L. Pintucci, K. M. Piper, A. Pirttikoski, D. A. Pizzi, L. Pizzimento, A. Pizzini, M.-A. Pleier, V. Pleskot, E. Plotnikova, G. Poddar, R. Poettgen, L. Poggioli, I. Pokharel, S. Polacek, G. Polesello, A. Poley, A. Polini, C. S. Pollard, Z. B. Pollock, E. Pompa Pacchi, N. I. Pond, D. Ponomarenko, L. Pontecorvo, S. Popa, G. A. Popeneciu, A. Poreba, D. M. Portillo Quintero, S. Pospisil, M. A. Postill, P. Postolache, K. Potamianos, P. A. Potepa, I. N. Potrap, C. J. Potter, H. Potti, J. Poveda, M. E. Pozo Astigarraga, A. Prades Ibanez, J. Pretel, D. Price, M. Primavera, L. Primomo, M. A. Principe Martin, R. Privara, T. Procter, M. L. Proffitt, N. Proklova, K. Prokofiev, G. Proto, J. Proudfoot, M. Przybycien, W. W. Przygoda, A. Psallidas, J. E. Puddefoot, D. Pudzha, D. Pyatiizbyantseva, J. Qian, D. Qichen, Y. Qin, T. Qiu, A. 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Steinberg, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T. J. Stevenson, G. A. Stewart, J. R. Stewart, M. C. Stockton, G. Stoicea, M. Stolarski, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Stratmann, M. Strauss, T. Strebler, P. Strizenec, R. Ströhmer, D. M. Strom, R. Stroynowski, A. Strubig, S. A. Stucci, B. Stugu, J. Stupak, N. A. Styles, D. Su, S. Su, W. Su, X. Su, D. Suchy, K. Sugizaki, V. V. Sulin, M. J. Sullivan, D. M. S. Sultan, L. Sultanaliyeva, S. Sultansoy, T. Sumida, S. Sun, O. Sunneborn Gudnadottir, N. Sur, M. R. Sutton, H. Suzuki, M. Svatos, M. Swiatlowski, T. Swirski, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, J. S. Tafoya Vargas, Y. Takubo, M. Talby, A. A. Talyshev, K. C. Tam, N. M. Tamir, A. Tanaka, J. Tanaka, R. Tanaka, M. Tanasini, Z. Tao, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G. F. Tartarelli, M. J. Tartarin, P. Tas, M. Tasevsky, E. Tassi, A. C. 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Tsukerman, V. Tsulaia, S. Tsuno, K. Tsuri, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, A. N. Tuna, S. Turchikhin, I. Turk Cakir, R. Turra, T. Turtuvshin, P. M. Tuts, S. Tzamarias, E. Tzovara, F. Ukegawa, P. A. Ulloa Poblete, E. N. Umaka, G. Unal, A. Undrus, G. Unel, J. Urban, P. Urrejola, G. Usai, R. Ushioda, M. Usman, F. Ustuner, Z. Uysal, V. Vacek, B. Vachon, T. Vafeiadis, A. Vaitkus, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, E. Valiente Moreno, A. Vallier, J. A. Valls Ferrer, D. R. Van Arneman, T. R. Van Daalen, A. Van Der Graaf, P. Van Gemmeren, M. Van Rijnbach, S. Van Stroud, I. Van Vulpen, P. Vana, M. Vanadia, W. Vandelli, E. R. Vandewall, D. Vannicola, L. Vannoli, R. Vari, E. W. Varnes, C. Varni, T. Varol, D. Varouchas, L. Varriale, K. E. Varvell, M. E. Vasile, L. Vaslin, G. A. Vasquez, A. Vasyukov, L. M. Vaughan, R. Vavricka, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M. J. Veen, I. Veliscek, L. M. Veloce, F. Veloso, S. Veneziano, A. 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Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H. J. Yang, H. T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. Yeo, M. R. Yexley, T. P. Yildirim, P. Yin, K. Yorita, S. Younas, C. J. S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z. K. Zak, T. Zakareishvili, S. Zambito, J. A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J. C. Zeng, D. T. Zenger, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D. F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N. I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T. G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Beyond Standard Model, Dark Matter, Exotics, Hadron-Hadron Scattering, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for dark mesons originating from strongly-coupled, SU(2) dark flavor symmetry conserving models and decaying gaugephobically to pure Standard Model final states containing top and bottom quarks is presented. The search targets fully hadronic final states and final states with exactly one electron or muon and multiple jets. The analyzed data sample corresponds to an integrated luminosity of 140 fb −1 of proton-proton collisions collected at s $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector at the Large Hadron Collider. No significant excess over the Standard Model background expectation is observed and the results are used to set the first direct constraints on this type of model. The two-dimensional signal space of dark pion masses m π D $$ {m}_{\pi_D} $$ and dark rho-meson masses m ρ D $$ {m}_{\rho_D} $$ is scanned. For m π D / m ρ D $$ {m}_{\pi_D}/{m}_{\rho_D} $$ = 0.45, dark pions with masses m π D $$ {m}_{\pi_D} $$ < 940 GeV are excluded at the 95% CL, while for m π D / m ρ D $$ {m}_{\pi_D}/{m}_{\rho_D} $$ = 0.25 masses m π D $$ {m}_{\pi_D} $$ < 740 GeV are excluded.
Published: 2024
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156. Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD

Author: Claudia Colussi, Alessia Bertozzi, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Federica Conte, Elena Paccosi, Luca Nardella, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Maria Gabriella Vita, Camillo Marra, Marcello D’Ascenzo, and Claudio Grassi
Subjects: Nucleoporin, Neurogenesis, Alzheimer’s disease, Organoids, Medicine (General), R5-920, Biochemistry, QD415-436
Abstract: Abstract Background Reduction of adult hippocampal neurogenesis is an early critical event in Alzheimer’s disease (AD), contributing to progressive memory loss and cognitive decline. Reduced levels of the nucleoporin 153 (Nup153), a key epigenetic regulator of NSC stemness, characterize the neural stem cells isolated from a mouse model of AD (3×Tg) (AD-NSCs) and determine their altered plasticity and gene expression. Methods Nup153-regulated mechanisms contributing to NSC function were investigated: (1) in cultured NSCs isolated from AD and wild type (WT) mice by proteomics; (2) in vivo by lentiviral-mediated delivery of Nup153 or GFP in the hippocampus of AD and control mice analyzing neurogenesis and cognitive function; (3) in human iPSC-derived brain organoids obtained from AD patients and control subjects as a model of neurodevelopment. Results Proteomic approach identified Nup153 interactors in WT- and AD-NSCs potentially implicated in neurogenesis regulation. Gene ontology (GO) analysis showed that Nup153-bound proteins in WT-NSCs were involved in RNA metabolism, nuclear import and epigenetic mechanisms. Nup153-bound proteins in AD-NSCs were involved in pathways of neurodegeneration, mitochondrial dysfunction, proteasomal processing and RNA degradation. Furthermore, recovery of Nup153 levels in AD-NSCs reduced the levels of oxidative stress markers and recovered proteasomal activity. Lentiviral-mediated delivery of Nup153 in the hippocampal niche of AD mice increased the proliferation of early progenitors, marked by BrdU/DCX and BrdU/PSANCAM positivity and, later, the integration of differentiating neurons in the cell granule layer (BrdU/NeuN+ cells) compared with GFP-injected AD mice. Consistently, Nup153-injected AD mice showed an improvement of cognitive performance in comparison to AD-GFP mice at 1 month after virus delivery assessed by Morris Water Maze. To validate the role of Nup153 in neurogenesis we took advantage of brain organoids derived from AD-iPSCs characterized by fewer neuroepithelial progenitor loops and reduced differentiation areas. The upregulation of Nup153 in AD organoids recovered the formation of neural-like tubes and differentiation. Conclusions Our data suggest that the positive effect of Nup153 on neurogenesis is based on a complex regulatory network orchestrated by Nup153 and that this protein is a valuable disease target.
Published: 2024
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157. Surgical site infection in severe trauma patients in intensive care: epidemiology and risk factors

Author: Lucie Savio, Pierre Simeone, Sophie Baron, François Antonini, Nicolas Bruder, Salah Boussen, Laurent Zieleskiewicz, Benjamin Blondel, Solène Prost, Guillaume Baucher, Marie Lebaron, Thibault Florant, Mohamed Boucekine, Marc Leone, and Lionel Velly
Subjects: Surgical site infections, Trauma, Risk factors, Microbiology, Outcomes, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Background Severe trauma is the leading cause of disability and mortality in the patients under 35 years of age. Surgical site infections (SSI) represent a significant complication in this patient population. However, they are often inadequately investigated, potentially impacting the quality of patient outcomes. The aim of this study was to investigate the epidemiology of SSI and risk factors in severe trauma patients. Methods We conducted a multicenter retrospective cohort study screening the severe trauma patients (STP) admitted to two intensive care units of an academic institution in Marseille between years2018 and 2019. Those who underwent orthopedic or spinal surgery within 5 days after admission were included and classified into two groups according to the occurrence of SSI (defined by the Centers for Disease Control (CDC) international diagnostic criteria) or not. Our secondary goal was to evaluate STP survival at 48 months, risk factors for SSI and microbiological features of SSI. Results Forty-seven (23%) out of 207 STP developed an SSI. Mortality at 48-months did not differ between SSI and non-SSI patients (12.7% vs. 10.0%; p = 0.59). The fractures of 22 (47%) severe trauma patients with SSI were classified as Cauchoix 3 grade and 18 (38%) SSI were associated with the need for external fixators. Thirty (64%) severe trauma patients with SSI had polymicrobial infection, including 34 (72%) due to Gram-positive cocci. Empirical antibiotic therapy was effective in 31 (66%) cases. Multivariate analysis revealed that risk factors such as low hemoglobin, arterial oxygenation levels, hyperlactatemia, high serum creatinine and glycemia, and Cauchoix 3 grade on the day of surgery were associated with SSI in severe trauma patients. The generated predictive model showed a good prognosis performance with an AUC of 0.80 [0.73–0.88] and a high NPV of 95.9 [88.6–98.5] %. Conclusions Our study found a high rate of SSI in severe trauma patients, although SSI was not associated with 48-month mortality. Several modifiable risk factors for SSI may be effectively managed through enhanced perioperative monitoring and the implementation of a patient blood management strategy.
Published: 2024
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158. Voice Analysis and Neural Networks as a Clinical Decision Support System for Patients With Lung Diseases

Author: Kamilla A. Bringel, Davi C.M.G. Leone, João Vitor L. de C. Firmino, MME, Marcelo C. Rodrigues, PhD, and Marcelo D.T. de Melo, MD, PhD
Subjects: Computer applications to medicine. Medical informatics, R858-859.7
Abstract: Objective: To analyze the voice of patients with lung diseases, compared with healthy individuals, to detect patterns capable of assessing dyspnea using artificial neural networks (ANNs). Patients and Methods: This research consists of a cross-sectional prospective pilot study performed in a reference tertiary center, which included a group of patients with lung diseases, compared with a group of healthy individuals. Each patient’s voice was recorded in controlled rooms. The following techniques were applied to extract and select signals’ features: statistical analysis, fast Fourier transform, discrete wavelet transform and Mel-Cepstral analysis. In addition, data augmentation was used to avoid overfitting and improve the ANNs accuracy. Results: A total of 195 voices were recorded: 131 from lung disease patients and 64 from healthy individuals, separated according to gender and age. Using data augmentation, 751 additional audio samples were generated: 501 from healthy individuals and 445 from patients with lung disease. Among male participants, 133 samples were related to lung diseases and 197 were related to healthy ones. From them, 264 audios were used for ANNs training, obtaining an accuracy of 89%. In the female group, 312 had lung diseases and 304 were healthy. Among them, 492 audios were used for training, resulting in an accuracy of 87.6%. Conclusion: Spectral analysis techniques applied to voice recordings using ANNs have reported high accuracy in the efficient diagnosis of lung diseases when compared with healthy individuals.
Published: 2024
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159. Conflicting Problem Representations and Creativity: Effects on Problem Construction

Author: Roni Reiter-Palmon, Salvatore Leone, and Emanuel Schreiner
Abstract: Contradictions and competing demands are common in everyday problems. To address these problems, individuals need to both recognize and integrate these contradictions during problem-solving to find creative solutions. We propose that recognition and integration take place in the problem construction phase of the creative problem-solving process. During problem construction, individuals work to develop their own understanding of the problem at hand. To do so, they sort through and combine problem representations activated through cues in the problem. We argue that the integration of conflicting and paradoxical elements in their understanding of the problem during problem construction is related to the originality and quality of proposed solutions beyond their initial ability to identify these elements. In a laboratory study, participants solved two different problems. We found that individuals identified more conflicting elements in the problem construction phase, but retained fewer of them in the problem-solving phase. Larger conflict between elements retained for problem solving resulted in more original and higher quality solutions to the problems.
Published: 2024
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160. College Student Alcohol Use and Confidence to Intervene in Interpersonal Violence: Differences by Gender and Sexual Orientation

Author: Ruschelle M. Leone, Daniel Oesterle, Harshita Yepuri, Debra L. Kaysen, Lindsay Orchowski, Kelly Cue Davis, and Amanda K. Gilmore
Abstract: Objectives: The current study examined the association between alcohol use frequency (ie, days a week one consumes alcohol), sexual and gender identity, and bystander confidence to intervene in interpersonal violence (ie, bystander self-efficacy). Participants: Participants were 750 undergraduate students aged 18-25 (260 heterosexual men, 260 heterosexual women, 59 SM men [54 cisgender, 5 transgender men], and 171 SM women [169 cisgender, 2 transgender women]). Methods: Participants completed an online survey about alcohol and sexual behaviors. Results: Results indicated that (1) alcohol use frequency was positively associated with greater bystander self-efficacy, (2) heterosexual men, compared to heterosexual women, reported lower bystander self-efficacy, and (3) the association between alcohol use frequency and bystander self-efficacy was significant and positive among heterosexual, but not SM, women. Conclusions: Prevention efforts may benefit from targeting individuals who drink more frequently and ensuring that they have the skills to effectively intervene.
Published: 2024
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161. A Mixed-Methods Study of a Poster Presentation Activity, Students' Science Identity, and Science Communication Self-Efficacy in Face-to-Face Teaching Conditions

Author: E. Austin Leone and Donald P. French
Abstract: The communication of scientific findings often concludes the research experience, but few science programs include explicit undergraduate curricula for practicing oral science communication. While course-based undergraduate research experiences (CUREs) can provide opportunities for students to practice science communication, few studies describe or assess authentic oral science communication activities within CUREs, and fewer do so under pandemic conditions. Little evidence exists describing how science communication activities impact students' science identity and science communication self-efficacy, specifically regarding research posters. To address this topic, we collected students' quantitative and qualitative perceptions of science identity and science communication self-efficacy in a face-to-face (F2F) CURE and collected students' qualitative perceptions of presenting their research at a F2F poster symposium during the COVID-19 pandemic. We found that students' science identity and science communication self-efficacy improved significantly, and we identified benefits and complaints about presenting research F2F during the pandemic--namely, a stimulating presentation atmosphere, face coverings as communication barriers and comforts, and audience type informing presentation confidence.
Published: 2024
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162. Acceptability of 'RealConsent': A Sexual Violence Web-Based Risk Reduction Program for College Women

Author: Anne Marie Schipani-McLaughlin, Laura F. Salazar, Ruschelle M. Leone, Dori Balser, Kate Hunley, and Kelly Quinn-Echevarria
Abstract: Acceptability of a sexual violence (SV) risk reduction program called "RealConsent" designed for first-year female college students was conducted as part of a larger, randomized controlled trial. "RealConsent" uses web-based and mobile technology to deliver four 45-minute theoretically and empirically derived modules designed to increase knowledge, affect attitudes and normative beliefs, increase bystander and other protective behaviors, and reduce alcohol misuse. Educational entertainment is used throughout the program to achieve these aims. A total of 444 first-year female college students recruited from three Southeastern universities who were eligible and provided informed consent were randomized to "RealConsent." Acceptability was ascertained both quantitatively and qualitatively through a survey administered following the completion of each of four modules. Results suggest that overall, "RealConsent" was viewed as relatable, realistic, and relevant. Most participants rated modules as good/excellent in quality, in organization, and in the conveying of a high degree of knowledge regarding alcohol misuse, consent for sex, sexual communication, defense strategies, protective strategies, and intervening to prevent SV. Suggestions to improve "RealConsent" centered on having more content inclusive of sexual and gender-minoritized students. Results suggest that "RealConsent" is an acceptable SV risk reduction program among first-year female college students and may have advantages for dissemination over in-person programs due to its web-based and mobile technology.
Published: 2024
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163. A Comparison of Measured Outcomes across Tree-Thinking Interventions

Author: Kristy L. Daniel, Daniel Ferguson, E. Austin Leone, and Carrie J. Bucklin
Abstract: Phylogenetic tree diagrams are commonly found in introductory biology curricula and represent the evolutionary relationships of organisms. Tree-thinking, or the ability to accurately interpret, use, and generate these phylogenetic representations, involves a challenging set of skills for students to learn. Although many introductory biology courses incorporate tree-thinking instruction, few studies have identified which instructional methods provide the best learning gains for students. We gathered data from 884 introductory biology students using the Basic Evolutionary Tree-Thinking Skills Inventory (BETTSI) to measure tree-thinking learning gains. We measured tree-thinking differences across five sections of introductory biology, each offering a different instructional intervention, and compared differences among STEM majors and non-STEM majors. After calculating paired differences, we performed a two-way repeated measure analysis of variance (ANOVA) and Scheffe's post hoc test to identify significant differences among and between the different interventions. We found that students who engaged in active tree-thinking instruction had significantly higher tree-thinking learning gains than students who participated in passive or no instruction. Furthermore, these learning gains became even more significant as active-learning became more multifaceted. These active-learning approaches also removed knowledge gaps between STEM majors and non-majors. Instructors must select explicit and active pedagogical approaches to support student tree-thinking to accomplish positive learning gains for all students.
Published: 2024
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164. Addressing Changes in Professional Behavior by Teacher Bonuses: A Mixed-Methods Approach

Author: Leone, Tharcisio
Abstract: How can a bonus program affect the performance of teachers in classrooms? This paper collected data from teachers employed in Brazilian state-run schools to examine the key mechanisms through which a teacher bonus scheme can have a causal effect on the academic achievements of students. Using mixed-methods research and data triangulation from questionnaires and semi-structured interviews with teachers, this study finds limited empirical evidence supporting the bonus program of the state of São Paulo. The bonus program created no additional incentive for educators to start/continue working in state schools, and it was not responsible for the improvement of teaching activities.
Published: 2024
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165. Urban High School Teacher Descriptions about Understanding and Navigating Workplace Pressures Associated with Burnout

Author: Stanley L. Leone
Abstract: The purpose of this qualitative descriptive study was to explore how urban high school teachers describe their understanding and navigation of workplace pressures that are associated with teacher burnout. Maslach's multidimensional burnout theory served as a framework for two research questions: (1) How do urban high school teachers describe their understanding of workplace pressures that are associated with teacher burnout? (2) How do urban high school teachers describe their navigation of workplace pressures that are associated with teacher burnout? Purposive sampling was used to recruit 18 public high school teachers. Data were collected from 11 semi-structured interviews, two focus groups of two participants, and one focus group of three participants. A thematic analysis of inductive coding generated four themes for research question 1: (1) Teacher stress. (2) Quiet quitting. (3) Workplace relationships. (4) Systems design. Analysis generated two themes for research question 2: (1) Teacher navigation of workplace pressures. (2) Quiet quitting. This study advanced understanding of how teachers understand and navigate workplace pressures that are associated with teacher burnout, with multiple aspects of workplace pressures being associated with the experience of workplace relationships. Findings may be applied to development, selection, and administration of teacher professional development in public education. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
Published: 2024

166. AI and Art

Author: Moruzzi, Caterina, primary and Campagner, Oreste Leone, additional
Published: 2024
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167. BUILD A SELL-OUT STADIUM CROWD: Mario Leone takes to the stage with a step-by-step guide to creating an arena full of cheering people in Houdini

Author: Leone, Mario
Subjects: Science and technology
Abstract: With so few online resources readily available for creating crowds, the ability to do just that in Houdini 20 was exciting for me. A crowd system is made up of [...]
Published: 2024

168. TAKE FLIGHT WITH HOUDINI'S FEATHER TOOLS: Mario Leone plucks the perfect feather using the new system in the latest Houdini release

Author: Leone, Mario
Subjects: Career development, Science and technology
Abstract: Being a 3D generalist isn't an easy path. It requires constant learning and adaptation to a variety of fields, but for those driven by curiosity and a thirst for knowledge, [...]
Published: 2024

169. Severe Pneumocystis jirovecii pneumonia: time to reassess our practices

Author: Nseir, Saad, Valadas, Emilia, and Leone, Marc
Published: 2024
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170. Pseudomagic Quantum States

Author: Gu, Andi, Leone, Lorenzo, Ghosh, Soumik, Eisert, Jens, Yelin, Susanne, and Quek, Yihui
Subjects: Quantum Physics
Abstract: Notions of nonstabilizerness, or "magic", quantify how non-classical quantum states are in a precise sense: states exhibiting low nonstabilizerness preclude quantum advantage. We introduce 'pseudomagic' ensembles of quantum states that, despite low nonstabilizerness, are computationally indistinguishable from those with high nonstabilizerness. Previously, such computational indistinguishability has been studied with respect to entanglement, introducing the concept of pseudoentanglement. However, we demonstrate that pseudomagic neither follows from pseudoentanglement nor implies it. In terms of applications, the study of pseudomagic offers fresh insights into the theory of quantum scrambling: it uncovers states that, even though they originate from non-scrambling unitaries, remain indistinguishable from scrambled states to any physical observer. Additional applications include new lower bounds on state synthesis problems, property testing protocols, and implications for quantum cryptography. Our work is driven by the observation that only quantities measurable by a computationally bounded observer - intrinsically limited by finite-time computational constraints - hold physical significance. Ultimately, our findings suggest that nonstabilizerness is a 'hide-able' characteristic of quantum states: some states are much more magical than is apparent to a computationally bounded observer., Comment: 32 pages, 3 figures, 1 table. Updated with the published version
Published: 2023
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171. Tachyons and Misaligned Supersymmetry in Orientifold Vacua

Author: Leone, Giorgio
Subjects: High Energy Physics - Theory
Abstract: We extend the analysis of Misaligned Supersymmetry to orientifold vacua. The lack of modular invariance in the Klein bottle, annulus and M\"obius strip amplitudes implies that the IR properties of the physical spectrum are related to the UV behaviour of closed strings freely propagating between D-branes and O-planes, and \emph{vice versa}. We thus build sector averaged sums $\langle d (n) \rangle$ associated to both representations of each Riemann surface. We find that the $\langle d (n) \rangle$'s associated to the loop channel control the coupling of closed-string tachyons to D-branes and/or O-planes, and therefore their vanishing is a necessary, but not sufficient, condition for stability in the closed sector. Similarly, the sector averaged sums associated to the tree-level amplitudes encode the presence of tachyons in the physical spectrum, and their vanishing is a sufficient, but not necessary, condition for classical stability. Using this technology, it is difficult, if not impossible, to formulate necessary and sufficient criteria for the absence of tachyons since, in orientifold vacua, they can be removed from the spectrum by the orientifold projection. Although in these cases one would naively expect a cancellation between $\langle d (n)\rangle$'s associated to different amplitudes, this does not occur in practice. We provide several examples in ten and lower dimensions supporting our results., Comment: 38 pages, corrected typos, modified comments to references (39) and (47)
Published: 2023

172. The Fracton quantum gas

Author: Villari, Leone Di Mauro and Principi, Alesssandro
Subjects: Condensed Matter - Quantum Gases, Condensed Matter - Strongly Correlated Electrons
Abstract: Starting from a simple dipole-conserving Hamiltonian model, after introducing a proper quantisation framework, we construct the linear-response theory of a fracton quantum gas. We show how to consistently construct the density operator and we calculate the density-density linear-response function in the limit of large number of (fracton) flavours. We show how to construct its random-phase approximation, from which we calculate the fracton-plasmon dispersion.
Published: 2023

173. Spin Coupling Effect on Geometry-Dependent X-ray Absorption of Diradicals

Author: Garner, Scott M., Haugen, Eric A., Leone, Stephen R., and Neuscamman, Eric
Subjects: Physics - Chemical Physics
Abstract: We theoretically investigate the influence of diradical electron spin coupling on the time-resolved X-ray absorption spectra of the photochemical ring opening of furanone. We predict geometry dependent carbon K-edge signals involving transitions from core orbitals to both singly and unoccupied molecular orbitals. The most obvious features of the ring opening come from the carbon atom directly involved in the bond breaking, through its transition to both the newly formed SOMO and the available LUMO state. In addition to this primary feature, the singlet spin coupling of four unpaired electrons that arises in the core-to-LUMO states creates additional geometry dependence in some spectral features, with both oscillator strengths and relative excitation energies varying observably as a function of the ring opening. We attribute this behavior to a spin-occupancy-induced selection rule, which occurs when singlet spin coupling is enforced in the diradical state. Notably, one of these geometry-sensitive core-to-LUMO transitions excites core electrons from a backbone carbon not involved in the bond breaking, providing a novel non-local X-ray probe of chemical dynamics arising from electron spin coupling., Comment: 52 Pages, 13 Figures
Published: 2023

174. Seven-probe scintillator dosimeter for treatment verification in HDR-brachytherapy

Author: Gonod, Mathieu, Suarez, Miguel Angel, Avila, Carlos Chacon, Karakhanyan, Vage, Eustache, Clement, Laskri, Samir, Crouzilles, Julien, Vinchant, Jean-Francois, Aubignac, Leone, and Grosjean, Thierry
Subjects: Physics - Instrumentation and Detectors, Physics - Medical Physics
Abstract: Purpose: We introduce a novel concept of a compact multiprobe scintillator detector and demonstrate its applicability in HDR-brachytherapy. Our fabricated seven-probe system is sufficiently narrow to be inserted in a brachytherapy needle or in a catheter. Methods: Our multiprobe detection system results from the parallel implementation of a miniaturized scintillator detector at the end of a bundle of seven fibers. The resulting system, which is narrower than 320 microns, is tested with a MicroSelectron 9.1 Ci Ir-192 HDR afterloader, in a water phantom. The detection signals from all seven probes are simultaneously read with an sCMOS camera (at a rate of 0.06 s). The camera is coupled to a chromatic filter to cancel Cerenkov signal induced within the fibers upon exposure. By implementing an aperiodic array of six scintillating cells along the bundle axis (one probe is kept bare to assess the stem effect), we first determine the range of inter-probe spacings leading to optimal source tracking accuracy. Then, three different source tracking algorithms involving sequentially or simultaneously all the scintillating probes are tested and compared. In each case, dwell positions are assessed from dose measurements and compared to the treatment plan. Dwell time is also determined and compared to the treatment plan. Results: The optimum inter-probe spacing for an accurate source tracking ranges from 15 mm to 35 mm. The optimum detection algorithm consists of adding the readout signals from all detector probes. In that case, the error to the planned dwell positions is of 0.01+/-0.14 mm and 0.02+/-0.29 mm at spacings between the source and detector axes of 5.5 and 40 mm, respectively. Using this approach, the average deviations to the expected dwell time are of -0.006+/-0.009 s and -0.008+/-0.058 s, at spacings between source and probe axes of 5.5 mm and 20 mm, respectively.
Published: 2023

175. Parametric modeling of mechanical effects on circadian oscillators

Author: Kennedy, Keith E., Abenza, Juan F., Rossetti, Leone, Trepat, Xavier, Villoslada, Pablo, and Garcia-Ojalvo, Jordi
Subjects: Quantitative Biology - Cell Behavior
Abstract: Circadian rhythms are archetypical examples of nonlinear oscillations. While these oscillations are usually attributed to circuits of biochemical interactions among clock genes and proteins, recent experimental studies reveal that they are also affected by the cell's mechanical environment. Here we extend a standard biochemical model of circadian rhythmicity to include mechanical effects in a parametric manner. Using experimental observations to constrain the model, we suggest specific ways in which the mechanical signal might affect the clock. Additionally, a bifurcation analysis of the system predicts that these mechanical signals need to be within an optimal range for circadian oscillations to occur., Comment: 6 pages, 7 figures
Published: 2023

176. Robust Twin Parametric Margin Support Vector Machine for Multiclass Classification

Author: De Leone, Renato, Maggioni, Francesca, and Spinelli, Andrea
Subjects: Computer Science - Machine Learning, Mathematics - Optimization and Control
Abstract: In this paper, we present novel Twin Parametric Margin Support Vector Machine (TPMSVM) models to tackle the problem of multiclass classification. We explore the cases of linear and nonlinear classifiers and propose two possible alternatives for the final decision function. Since real-world observations are plagued by measurement errors and noise, data uncertainties need to be considered in the optimization models. For this reason, we construct bounded-by-norm uncertainty sets around each sample and derive the robust counterpart of deterministic models by means of robust optimization techniques. Finally, we test the proposed TPMSVM methodology on real-world datasets, showing the good performance of the approach.
Published: 2023

177. Graph Fourier MMD for Signals on Graphs

Author: Leone, Samuel, Venkat, Aarthi, Huguet, Guillaume, Tong, Alexander, Wolf, Guy, and Krishnaswamy, Smita
Subjects: Computer Science - Machine Learning, Statistics - Machine Learning
Abstract: While numerous methods have been proposed for computing distances between probability distributions in Euclidean space, relatively little attention has been given to computing such distances for distributions on graphs. However, there has been a marked increase in data that either lies on graph (such as protein interaction networks) or can be modeled as a graph (single cell data), particularly in the biomedical sciences. Thus, it becomes important to find ways to compare signals defined on such graphs. Here, we propose Graph Fourier MMD (GFMMD), a novel distance between distributions and signals on graphs. GFMMD is defined via an optimal witness function that is both smooth on the graph and maximizes difference in expectation between the pair of distributions on the graph. We find an analytical solution to this optimization problem as well as an embedding of distributions that results from this method. We also prove several properties of this method including scale invariance and applicability to disconnected graphs. We showcase it on graph benchmark datasets as well on single cell RNA-sequencing data analysis. In the latter, we use the GFMMD-based gene embeddings to find meaningful gene clusters. We also propose a novel type of score for gene selection called "gene localization score" which helps select genes for cellular state space characterization.
Published: 2023

178. Recurring volcanic winters during the latest Cretaceous: Sulfur and fluorine budgets of Deccan Traps lavas.

Author: Callegaro, Sara, Baker, Don, Renne, Paul, Melluso, Leone, Geraki, Kalotina, Whitehouse, Martin, De Min, Angelo, and Marzoli, Andrea
Abstract: Two events share the stage as main drivers of the Cretaceous-Paleogene mass extinction-Deccan Traps volcanism, and an asteroid impact recorded by the Chicxulub crater. We contribute to refining knowledge of the volcanic stressor by providing sulfur and fluorine budgets of Deccan lavas from the Western Ghats (India), which straddle the Cretaceous-Paleogene boundary. Volcanic fluorine budgets were variable (400 to 3000 parts per million) and probably sufficient to affect the environment, albeit only regionally. The highest sulfur budgets (up to 1800 parts per million) are recorded in Deccan lavas emplaced just prior (within 0.1 million years) to the extinction interval, whereas later basalts are generally sulfur-poor (up to 750 parts per million). Independent evidence suggests the Deccan flood basalts erupted in high-flux pulses. Our data suggest that volcanic sulfur degassing from such activity could have caused repeated short-lived global drops in temperature, stressing the ecosystems long before the bolide impact delivered its final blow at the end of the Cretaceous.
Published: 2023

179. On Cyber-Envy

Author: Leone, Massimo, Marusek, Sarah, Series Editor, Wagner, Anne, Series Editor, Aroso Linhares, José Manuel, Advisory Editor, Backer, Larry Catá, Advisory Editor, Bankov, Kristian, Advisory Editor, Bhatia, Vijay, Advisory Editor, Biber, Katherine, Advisory Editor, Branco, Patrícia, Advisory Editor, Brigham, John, Advisory Editor, Broekman, Jan, Advisory Editor, Condello, Angela, Advisory Editor, Cramer, Renee Ann, Advisory Editor, Danesi, Marcel, Advisory Editor, Dudek, Michał, Advisory Editor, Featherstone, Mark, Advisory Editor, Franca-Filho, Marcilio Toscano, Advisory Editor, Hauksson-Tresch, Nathalie, Advisory Editor, Hu, Lung-Lung, Advisory Editor, Könczöl, Miklós, Advisory Editor, Lam, Anita, Advisory Editor, Leone, Massimo, Advisory Editor, Mangiapane, Francesco, Advisory Editor, Matulewska, Aleksandra, Advisory Editor, Neuwirth, Rostam J., Advisory Editor, Peters, Timothy D., Advisory Editor, Philippopoulos-Mihalopoulos, Andreas, Advisory Editor, Powell, Richard, Advisory Editor, Ricca, Mario, Advisory Editor, Shaw, Julia J. A., Advisory Editor, Sherwin, Richard K., Advisory Editor, Stępień, Mateusz, Advisory Editor, Tranter, Kieran Mark, Advisory Editor, Vanegas, Farid Samir Benavides, Advisory Editor, Vecellio Segate, Riccardo, Advisory Editor, Voinot, Denis, Advisory Editor, and Youping, Xu, Advisory Editor
Published: 2024
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180. Milk Matters in Malnutrition, is it the Lactose or Dairy Protein?

Author: Project Peanut Butter, Sierra Leone
Published: 2024

181. Detection of regions of homozygosity in an unusual case of frontonasal dysplasia

Author: Paz-y-Miño, César, Vargas-Vera, Ramón Miguel, Placencia-Ibadango, Martha Verónica, Vargas-Silva, Kalid Stefano, García-Hernández, Juan Luis, Balarezo-Díaz, Thalía, and Leone, Paola E.
Published: 2024
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182. Prospective analysis of sex differences and factors associated with suicidal thoughts and behaviours in young people from the MILESTONE Italian sample

Author: Torino, Gabriele, Leone, Silvia, Cortese, Samuele, Dieleman, Gwen, Gerritsen, Suzanne, Maffezzoni, Deborah, Martella, Donato, Micciolo, Rocco, Singh, Swaran, Street, Cathy, Tuffrey, Amanda, Walker, Leanne, Zamparini, Manuel, and de Girolamo, Giovanni
Published: 2024
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183. Evaluation of criterion-based audit in improving quality of neonatal birth asphyxia care at Balaka district hospital in Malawi

Author: Mwalweni, Chank, Chirwa, Ellen Mbweza, Chimala, Eveles Banda, Shaba, Mirriam Window, Lowole, Leone, Kasawala, Lucia, and Mwakhundi, Christina Kalawa
Published: 2024
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184. Physical Activity in young female outpatients with BORderline personality Disorder (PABORD): a study protocol for a randomized controlled trial (RCT)

Author: de Girolamo, Giovanni, Leone, Silvia, D’Addazio, Miriam, Toffol, Elena, Martinelli, Alessandra, Bellini, Sonia, Calza, Stefano, Carnevale, Martina, Cattane, Nadia, Cattaneo, Annamaria, Ghidoni, Roberta, Longobardi, Antonio, Maffezzoni, Deborah, Martella, Donato, Meloni, Serena, Mombelli, Elisa, Pogliaghi, Silvia, Saraceno, Claudia, Tura, Giovanni Battista, and Rossi, Roberta
Published: 2024
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185. Biochar improves growth and physiology of Swietenia macrophylla king in contaminated soil by copper

Author: da Cruz Ferreira, Raphael Leone, Braga, Dayse Gonzaga, do Nascimento, Vitor Resende, da Silva, Camilly Barbosa, Alves, Anne Cristina Barbosa, da Costa Cabral, Joyce Adriany, Cruz, Flávio José Rodrigues, de Araújo Brito, Ana Ecídia, dos Santos Nogueira, Glauco Andre, de Souza, Luma Castro, Cruz, Eniel David, and Neto, Cândido Ferreira Oliveira
Published: 2024
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186. Reliability of crackles in fibrotic interstitial lung disease: a prospective, longitudinal study

Author: Sgalla, Giacomo, Simonetti, Jacopo, Di Bartolomeo, Arianna, Magrì, Tonia, Iovene, Bruno, Pasciuto, Giuliana, Dell’Ariccia, Ruben, Varone, Francesco, Comes, Alessia, Leone, Paolo Maria, Piluso, Venere, Perrotta, Alessandro, Cicchetti, Giuseppe, Verdirosi, Diana, and Richeldi, Luca
Published: 2024
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187. Randomized phase 2 study of valproic acid combined with simvastatin and gemcitabine/nab-paclitaxel-based regimens in untreated metastatic pancreatic adenocarcinoma patients: the VESPA trial study protocol

Author: Budillon, Alfredo, Leone, Alessandra, Passaro, Eugenia, Silvestro, Lucrezia, Foschini, Francesca, Iannelli, Federica, Roca, Maria Serena, Macchini, Marina, Bruzzese, Francesca, Garcia Bermejo, Maria Laura, Rodriguez Garrote, Mercedes, Tortora, Giampaolo, Milella, Michele, Reni, Michele, Fuchs, Claudia, Hewitt, Eve, Kubiak, Christine, Di Gennaro, Elena, Giannarelli, Diana, and Avallone, Antonio
Published: 2024
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188. Exploring stroke survivors’ and physiotherapists’ perspectives of the potential for markerless motion capture technology in community rehabilitation

Author: Faux-Nightingale, Alice, Philp, Fraser, Leone, Enza, Helliwell, Brinton Boreman, and Pandyan, Anand
Published: 2024
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189. Group A Streptococcus infections in children and adolescents in the post-COVID-19 era: a regional Italian survey

Author: Cinicola, Bianca Laura, Sani, Ilaria, Pulvirenti, Federica, Capponi, Martina, Leone, Fabrizio, Spalice, Alberto, Montalbano, Agata, Macari, Alessandra, Fonte, Maria Teresa, Giampietro, Paolo Gianni, Buonsenso, Danilo, Zicari, Anna Maria, and Rongai, Teresa
Published: 2024
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190. Clinical significance of postoperative thrombocytosis after vats lobectomy for NSCLC

Author: Leonardi, Beatrice, Natale, Giovanni, Ferraioli, Salvatore, Leone, Francesco, Grande, Mario, Puca, Maria Antonietta, Rainone, Anna, Messina, Gaetana, Sica, Antonello, and Fiorelli, Alfonso
Published: 2024
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191. Structural connectivity modifications following deep brain stimulation of the subcallosal cingulate and nucleus accumbens in severe anorexia nervosa

Author: Abellaneda-Pérez, Kilian, Delgado-Martínez, Ignacio, Salgado, Purificación, Ginés, José María, Guardiola, Rocío, Vaqué-Alcázar, Lídia, Roca-Ventura, Alba, Molist-Puigdomènech, Roger, Manero, Rosa María, Viles-Garcia, Marc, Medrano-Martorell, Santiago, Bartrés-Faz, David, Pascual-Leone, Alvaro, Pérez-Solà, Víctor, and Villalba-Martínez, Gloria
Published: 2024
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192. Digital speech hearing screening using a quick novel mobile hearing impairment assessment: an observational correlation study

Author: Banks, Russell, Greene, Barry R., Morrow, Isaiah, Ciesla, Marissa, Woolever, David, Tobyne, Sean, Gomes-Osman, Joyce, Jannati, Ali, Showalter, John, Bates, David, and Pascual-Leone, Alvaro
Published: 2024
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193. The NEREA Augmented Observatory: an integrative approach to marine coastal ecology

Author: Campese, Lucia, Russo, Luca, Abagnale, Maria, Alberti, Adriana, Bachi, Giancarlo, Balestra, Cecilia, Bellardini, Daniele, Buondonno, Angela, Cardini, Ulisse, Carotenuto, Ylenia, Checcucci, Giovanni, Chiusano, Maria Luisa, D’Ambra, Isabella, d’Ippolito, Giuliana, Di Capua, Iole, Donnarumma, Vincenzo, Fontana, Angelo, Furia, Marta, Galarza-Verkovitch, Denisse, Gallia, Roberto, Labadie, Karine, Leone, Serena, Licandro, Priscilla, Longo, Antonio, Maselli, Maira, Merquiol, Louise, Murano, Carola, Oliveira, Pedro H., Passarelli, Augusto, Percopo, Isabella, Perdereau, Aude, Piredda, Roberta, Raffini, Francesca, Roncalli, Vittoria, Ruscheweyh, Hans-Joachim, Russo, Ennio, Saggiomo, Maria, Santinelli, Chiara, Sarno, Diana, Sunagawa, Shinichi, Tramontano, Ferdinando, Trano, Anna Chiara, Uttieri, Marco, Wincker, Patrick, Zampicinini, Gianpaolo, Casotti, Raffaella, Conversano, Fabio, D’Alelio, Domenico, Iudicone, Daniele, Margiotta, Francesca, and Montresor, Marina
Published: 2024
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194. Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy

Author: Giammello, Francesca, Biella, Chiara, Priori, Erica Cecilia, Filippo, Matilde Amat Di San, Leone, Roberta, D’Ambrosio, Francesca, Paterno’, Martina, Cassioli, Giulia, Minetti, Antea, Macchi, Francesca, Spalletti, Cristina, Morella, Ilaria, Ruberti, Cristina, Tremonti, Beatrice, Barbieri, Federica, Lombardi, Giuseppe, Brambilla, Riccardo, Florio, Tullio, Galli, Rossella, Rossi, Paola, and Brandalise, Federico
Published: 2024
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195. Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD

Author: Colussi, Claudia, Bertozzi, Alessia, Leone, Lucia, Rinaudo, Marco, Sollazzo, Raimondo, Conte, Federica, Paccosi, Elena, Nardella, Luca, Aceto, Giuseppe, Puma, Domenica Donatella Li, Ripoli, Cristian, Vita, Maria Gabriella, Marra, Camillo, D’Ascenzo, Marcello, and Grassi, Claudio
Published: 2024
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196. Surgical site infection in severe trauma patients in intensive care: epidemiology and risk factors

Author: Savio, Lucie, Simeone, Pierre, Baron, Sophie, Antonini, François, Bruder, Nicolas, Boussen, Salah, Zieleskiewicz, Laurent, Blondel, Benjamin, Prost, Solène, Baucher, Guillaume, Lebaron, Marie, Florant, Thibault, Boucekine, Mohamed, Leone, Marc, and Velly, Lionel
Published: 2024
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197. Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

Author: Essex, Morgan, Millet Pascual-Leone, Belén, Löber, Ulrike, Kuhring, Mathias, Zhang, Bowen, Brüning, Ulrike, Fritsche-Guenther, Raphaela, Krzanowski, Marta, Fiocca Vernengo, Facundo, Brumhard, Sophia, Röwekamp, Ivo, Anna Bielecka, Agata, Lesker, Till Robin, Wyler, Emanuel, Landthaler, Markus, Mantei, Andrej, Meisel, Christian, Caesar, Sandra, Thibeault, Charlotte, Corman, Victor M., Marko, Lajos, Suttorp, Norbert, Strowig, Till, Kurth, Florian, Sander, Leif E., Li, Yang, Kirwan, Jennifer A., Forslund, Sofia K., and Opitz, Bastian
Published: 2024
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198. Genomic profiling and comparative analysis of male versus female metastatic breast cancer across subtypes

Author: Kadamkulam Syriac, Arun, Nandu, Nitish Singh, Clark, Allison, Tavallai, Mehrad, Jin, Dexter X., Sokol, Ethan, McGregor, Kimberly, Ross, Jeffrey S., Danziger, Natalie, and Leone, Jose Pablo
Published: 2024
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199. Editorial

Author: Blum, Alexander S. and Leone, Matteo
Published: 2024
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200. An amplicon-based sequencing approach for Usutu virus characterization

Author: Ndione, Marie Henriette Dior, Diagne, Moussa Moïse, Mencattelli, Giulia, Diallo, Amadou, Ndiaye, El Hadji, Di Domenico, Marco, Diallo, Diawo, Kane, Mouhamed, Curini, Valentina, Top, Ndeye Marieme, Marcacci, Maurilia, Sankhe, Safiétou, Ancora, Massimo, Secondini, Barbara, Di Lollo, Valeria, Teodori, Liana, Leone, Alessandra, Puglia, Ilaria, Gaye, Alioune, Sall, Amadou Alpha, Loucoubar, Cheikh, Rosà, Roberto, Diallo, Mawlouth, Monaco, Federica, Faye, Ousmane, Cammà, Cesare, Rizzoli, Annapaola, Savini, Giovanni, and Faye, Oumar
Published: 2024
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