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857 results on '"Lembo G"'

152. Meccanismi della vasocostrizione coronarica dopo singola angioplastica effettuata con successo del ramo discendente anteriore della coronaria sinistra

Author

RAPACCIUOLO, ANTONIO, CHIARIELLO, MASSIMO, Indolfi C, Piscione F, ESPOSITO, GIOVANNI, Maione AG, Lembo G, Esposito N, Gargiulo G, Rapacciuolo, Antonio, Indolfi, C, Piscione, F, Esposito, Giovanni, Maione, Ag, Lembo, G, Esposito, N, Gargiulo, G, and Chiariello, Massimo

Subjects
Angioplastica, coronaria sinistra, vasocostrizione coronarica, ramo discendente anteriore
Published
1992

161. Skeletal muscle is a primary site of insulin resistance in essential hypertension

Author

Lembo, G, Napoli, R, Rendina, V, Albano, G, Saccà, L, Trimarco, B, Lembo, G, Napoli, R, Rendina, V, Albano, G, Saccà, L, and Trimarco, B

Subjects
Blood Glucose, Forearm, Regional Blood Flow, Hypertension, Insulin, Muscle, Reference Value, Insulin Resistance, Human
Abstract

To determine the contribution of skeletal muscle to the insulin resistance of essential hypertension, insulin-stimulated forearm glucose uptake was quantitated in 12 control (age, 32 +/- 3 years) and 12 hypertensive subjects (age, 36 +/- 2 years) using the forearm perfusion technique. Peripheral insulin levels were raised acutely (approximately 60 microU/mL), while blood glucose concentration was clamped at its basal value (90 mg/dL) by a variable glucose infusion. During insulin stimulation, whole body glucose uptake was lower in hypertensive (4.5 +/- .3 mg.kg-1.min-1) than in normal subjects (5.8 +/- .4 mg.kg-1.min-1, P less than .05). Similarly, the amount of glucose taken up by the forearm was markedly reduced in the hypertensive (5.3 +/- .91 mg.L-1.min-1) compared with the control group (8.7 +/- 1.1 mg.L-1.min-1). No appreciable difference was observed as to forearm blood flow (39 +/- 4 mL.L-1.min-1 and 37 +/- 5 mL.L-1.min-1) in hypertensive patients. These results indicate that skeletal muscle is a major site of insulin resistance in essential hypertension and that this defect is independent of muscle perfusion.

Published
1991

163. La scintigrafia con 131I metaiodobenzilguanidina in pazienti con sospetto feocromocitoma: confronto con TC e parametri bioumorali

Author

Maurelli L, Cuocolo A, Lastoria S, Lembo G, Klain M, Caracò C, Salvatore M., BRUNETTI, ARTURO, MAUREA, SIMONE, Maurelli, L, Cuocolo, A, Lastoria, S, Brunetti, Arturo, Maurea, Simone, Lembo, G, Klain, M, Caracò, C, and Salvatore, M.

Abstract

The results of 131I metaiodobenzylguanidine (MIBG) and Computed Tomography (CT) scans in a group of patients with clinically suspected pheochromocytoma were evaluated and compared with biohumoral parameters. We studied 24 consecutive patients (7 M and 17 F; age range 20-66 years). 131I-MIBG scintigraphy and CT were in agreement in 19 patients (79%): of them 7 cases were true positive, and 12 were true negative. Disagreement between the two imaging techniques was observed in 5 patients (21%). In this group, one patient, with positive CT scan, had false negative MIBG study, while 4 patients with negative MIBG scan, had false positive CT. MIBG showed significantly higher (p less than 0.05) specificity (100%), positive predictive value (100%), and accuracy (96%) than CT (75%, 67%, and 83%, respectively). 131I-MIBG scintigraphy is an accurate, noninvasive technique for localizing pheochromocytoma and providing direct tissue characterization, while CT provides more accurate spatial information. In conclusion, CT and MIBG studies are complementary in the evaluation of patients with suspected pheochromocytoma

Published
1991

190. [Arterial hypertension and atherosclerosis: their epidemiology and physiopathology]

Author

Lembo G, Carmine Vecchione, Morisco C, Fratta L, Argenziano L, Sarno D, and Trimarco B

Subjects
Arteriosclerosis, Humans, Hypertension, Risk Factors
Abstract

Several epidemiologic studies have demonstrated that hypertensive patients have an increased risk for the development of atherosclerosis. Although the appearance of atherosclerosis only in those parts of vascular system subjected to high blood pressure suggests that the mechanical stress is the principal factor involved in the development of atherosclerosis, the mechanisms underlying the linkage between hypertension and atherosclerosis are not yet completely understood. In fact, the evidence that antihypertensive treatments are not able to abolish the increased incidence of ischemic accidents in hypertensive patients suggests that other cellular and molecular mechanisms are involved in the pathogenesis of atherosclerosis. The pathogenesis of hypertension is a multifactorial process that involves the interaction of genetic and environmental factors which determine the abnormalities of volume regulation, the enhanced vasoconstriction and the remodeling of the arterial wall which is characterized by hypertrophy and proliferation of vascular smooth muscle cells. On the other hand, the increased growth response of vascular smooth muscle cells represents one of the principal characteristics of atherosclerosis. Thus, increased vascular smooth muscle cell growth is a common feature in the pathogenesis of both atherosclerosis and hypertension.

Published
1995

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