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187. Onkologische Diagnostik.

Author

Wannenmacher, M., Debus, J., Wenz, F., Lukas, P., Sweeney, R., Felber, S., Lell, M., Bautz, W., Frede, T., Nömayr, A., Trieb, T. R., and Judmaier, W.

Published
2006
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191. Einfluss hoher vs. niedriger Reizintensität auf die Ausdauerleistungsfähigkeit untrainierter Männer - die RUSH-Studie.

Author

Kemmler, W., Tutor, M., Lell, M., Scharf, M., Fraunberger, L., and von Stengel, S.

Abstract

Copyright of German Journal of Sports Medicine / Deutsche Zeitschrift fur Sportmedizin is the property of Verein zur Forderung der Sportmedizin Hannover e.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014
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195. Effect of CT scan protocols on x-ray-induced DNA double-strand breaks in blood lymphocytes of patients undergoing coronary CT angiography.

Author

Kuefner MA, Grudzenski S, Hamann J, Achenbach S, Lell M, Anders K, Schwab SA, Häberle L, Löbrich M, Uder M, Kuefner, M A, Grudzenski, S, Hamann, J, Achenbach, S, Lell, Michael, Anders, K, Schwab, S A, Häberle, L, Löbrich, M, and Uder, M

Abstract

Aims: To compare in vivo DNA lesions induced during helical and sequential coronary computed tomography angiography (CTA) and to evaluate the effect of CT parameters on double-strand break (DSB) levels.Methods: Thirty-six patients were examined with various CT protocols and modes (helical scan, n = 27; sequential scan, n = 9) either using a 64-slice dual-source or a 128-slice CT system. Blood samples were obtained before and 30 min after CT. Lymphocytes were isolated, stained against the phosphorylated histone variant γ-H2AX, and DSBs were visualised by using fluorescence microscopy.Results: DSB yields 30 min after CTA ranged from 0.04 to 0.71 per cell and showed a significant correlation to DLP (ρ = 0.81, p < 0.00001). Median DSB yield and median DLP were significantly lower after sequential compared to helical CT examinations (0.11 vs. 0.37 DSBs/cell and 249 vs. 958 mGy cm, p < 0.00001). Additional calcium scoring led to an increase in DLP (p = 0.15) and DSB levels (p = 0.04). DSB levels normalised to the DLP showed a significant correlation to the attenuation of the blood (ρ = 0.53, p = 0.01) and a negative correlation to the body mass index of the patients (ρ = -0.37, p = 0.06).Conclusion: γ-H2AX immunofluorescence microscopy allows one to determine dose-related effects on x-ray-induced DSB levels and to consider individual factors which cannot be monitored by physical dose measurements. [ABSTRACT FROM AUTHOR]

Published
2010
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196. Radiation exposure and image quality in staged low-dose protocols for coronary dual-source CT angiography: a randomized comparison.

Author

Pflederer T, Jakstat J, Marwan M, Schepis T, Bachmann S, Kuettner A, Anders K, Lell M, Muschiol G, Ropers D, Daniel WG, Achenbach S, Pflederer, Tobias, Jakstat, Josy, Marwan, Mohamed, Schepis, Tiziano, Bachmann, Sven, Kuettner, Axel, Anders, Katharina, and Lell, Michael

Abstract

Objective: To evaluate staged low-dose approaches for coronary CT angiography (CTA) in which a standard sequence was added if the low-dose sequence did not allow reliable rule-out of coronary stenosis.Patients and Methods: A total of 176 consecutive patients referred for dual-source CTA were randomized to three protocols: group 1 using prospective ECG-triggering (100 kV, 330 mAs), group 2 a retrospectively gated "MinDose" sequence (100 kV, 330 mAs) and group 3 a standard spiral sequence (120 kV, 400 mAs). If image quality in low-dose groups 1 or 2 was non-diagnostic, an additional standard CT examination (as in group 3) was performed.Results: Non-diagnostic image quality was found in 11/56, 4/55, and 2/65 patients (46/896, 4/880 and 3/1,040 coronary segments) in groups 1, 2 and 3, respectively. Median (interquartile ranges) volumes of contrast material, CTDI(vol), DLP and effective dose for low-dose groups 1 and 2 and for standard group 3 were 92.5 (11.3), 75.0 (2.5) and 75.0 (9.0) ml; 8.0 (1.4), 16.8 (4.8) and 48.1 (14.2) mGy; 108.0 (27.3), 246.0 (93.0) and 701.0 (207.8) mGy cm; and 1.5 (0.4), 3.4 (1.3) and 9.8 (2.9) mSv, respectively.Conclusion: A staged coronary CTA protocol with an initial low-dose approach and addition of a standard sequence--should image quality be too low--can lead to a substantial reduction in radiation exposure. [ABSTRACT FROM AUTHOR]

Published
2010
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197. Prospectively ECG-triggered high-pitch spiral acquisition for coronary CT angiography using dual source CT: technique and initial experience.

Author

Lell M, Marwan M, Schepis T, Pflederer T, Anders K, Flohr T, Allmendinger T, Kalender W, Ertel D, Thierfelder C, Kuettner A, Ropers D, Daniel WG, Achenbach S, Lell, Michael, Marwan, Mohamed, Schepis, Tiziano, Pflederer, Tobias, Anders, Katharina, and Flohr, Thomas

Abstract

Objective: We evaluated radiation exposure and image quality of a new coronary CT angiography protocol, high-pitch spiral acquisition, using dual source CT (DSCT).Material and Methods: Coronary CTAwas performed in 25 consecutive patients with a stable heart rate of 60 bpm or less after premedication, using 2 x 128 0.6-mm sections, 38.4-mm collimation width and 0.28-s rotation time. Tube settings were 100 kV/320 mAs and 120 kV/400 mAs for patients below and above 100-kg weight, respectively. Data acquisition was prospectively ECG-triggered at 60% of the R-R interval using a pitch of 3.2 (3.4 for the last 10 patients). Images were reconstructed with 75-ms temporal resolution, 0.6-mm slice thickness and 0.3-mm increment. Image quality was evaluated using a four-point scale (1 = excellent, 4 = unevaluable).Results: Mean range of data acquisition was 113 +/- 22 mm, mean duration was 268 +/- 23 ms. Of 363 coronary artery segments, 327 had an image quality score of 1, and only 2 segments were rated as "unevaluable". Mean dose-length product (DLP) was 71 +/- 23 mGy cm, mean effective dose was 1.0 +/- 0.3 mSv (range 0.78-2.1 mSv). For 21 patients with a body weight below 100 kg, mean DLP was 63 +/- 5 mGy cm (0.88 +/- 0.07 mSv; range 0.78-0.97 mSv).Conclusion: Prospectively ECGtriggered high-pitch spiral CT acquisition provides high and stable image quality at very low radiation dose. [ABSTRACT FROM AUTHOR]

Published
2009
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198. Erratum zu: Leitlinie „Rhinosinusitis" – Langfassung: S2k-Leitlinie der Deutschen Gesellschaft für Allgemeinmedizin und Familienmedizin und der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V

Author

Stuck, B. A., Beule, A., Jobst, D., Klimek, L., Laudien, M., Lell, M., Vogl, T. J., and Popert, U.

Abstract

Copyright of HNO is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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