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154. Does whole-body bone SPECT/CT provide additional diagnostic information over [18F]-FCH PET/CT for the detection of bone metastases in the setting of prostate cancer biochemical recurrence?

Author

de Leiris, Nicolas, Leenhardt, Julien, Boussat, Bastien, Montemagno, Christopher, Seiller, Alexandre, Phan Sy, Olivier, Roux, Julie, Laramas, Mathieu, Verry, Camille, Iriart, Carole, Fiard, Gaelle, Long, Jean-Alexandre, Descotes, Jean-Luc, Vuillez, Jean-Philippe, Riou, Laurent, and Djaileb, Loïc

Published
2020
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156. Nouveautés dans la prise en charge des angiodysplasies digestives.

Author

Ginestet, Claire, Ouazana, Salomé, Houdeville, Charles, Leenhardt, Romain, Becq, Aymeric, and Dray, Xavier

Subjects
CAPSULE endoscopy, ARTIFICIAL intelligence, THALIDOMIDE
Abstract

Copyright of Hépato-Gastro & Oncologie Digestive is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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157. Artificial Intelligence-assisted Analysis of Pan-enteric Capsule Endoscopy in Patients with Suspected Crohn's Disease: A Study on Diagnostic Performance.

Author

Brodersen, Jacob Broder, Jensen, Michael Dam, Leenhardt, Romain, Kjeldsen, Jens, Histace, Aymeric, Knudsen, Torben, and Dray, Xavier

Abstract

Background and Aim Pan-enteric capsule endoscopy [PCE] is a highly sensitive but time-consuming tool for detecting pathology. Artificial intelligence [AI] algorithms might offer a possibility to assist in the review and reduce the analysis time of PCE. This study examines the agreement between PCE assessments aided by AI technology and standard evaluations, in patients suspected of Crohn's disease [CD]. Method PCEs from a prospective, blinded, multicentre study, including patients suspected of CD, were processed by the deep learning solution AXARO® [Augmented Endoscopy, Paris, France]. Based on the image output, two observers classified the patient's PCE as normal or suggestive of CD, ulcerative colitis, or cancer. The primary outcome was per-patient sensitivities and specificities for detecting CD and inflammatory bowel disease [IBD]. Complete reading of PCE served as the reference standard. Results A total of 131 patients' PCEs were analysed, with a median recording time of 303 min. The AXARO® framework reduced output to a median of 470 images [2.1%] per patient, and the pooled median review time was 3.2 min per patient. For detecting CD, the observers had a sensitivity of 96% and 92% and a specificity of 93% and 90%, respectively. For the detection of IBD, both observers had a sensitivity of 97% and had a specificity of 91% and 90%, respectively. The negative predictive value was 95% for CD and 97% for IBD. Conclusions Using the AXARO® framework reduced the initial review time substantially while maintaining high diagnostic accuracy—suggesting its use as a rapid tool to rule out IBD in PCEs of patients suspected of Crohn's disease. [ABSTRACT FROM AUTHOR]

Published
2024
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162. Extracorporeal Membrane Oxygenation to Support Life-Threatening Drug-Refractory Electrical Storm

Author

Baudry, Guillaume, Sonneville, Romain, Waintraub, Xavier, Lebreton, Guillaume, Deguillard, Camille, Mertens, Emilie, Bouadma, Lila, Demondion, Pierre, Bréchot, Nicolas, Luyt, Charles-Edouard, Extramiana, Fabrice, Hékimian, Guillaume, Dupuis, Claire, Para, Marylou, Pisani, Angelo, Braham, Wael, Gandjbakhch, Estelle, Leenhardt, Antoine, Timsit, Jean-François, Leprince, Pascal, Combes, Alain, and Schmidt, Matthieu

Published
2020
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163. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

Author

Lahrouchi, Najim, Tadros, Rafik, Crotti, Lia, Mizusawa, Yuka, Postema, Pieter G., Beekman, Leander, Walsh, Roddy, Hasegawa, Kanae, Barc, Julien, Ernsting, Marko, Turkowski, Kari L., Mazzanti, Andrea, Beckmann, Britt M., Shimamoto, Keiko, Diamant, Ulla-Britt, Wijeyeratne, Yanushi D., Kucho, Yu, Robyns, Tomas, Ishikawa, Taisuke, Arbelo, Elena, Christiansen, Michael, Winbo, Annika, Jabbari, Reza, Lubitz, Steven A., Steinfurt, Johannes, Rudic, Boris, Loeys, Bart, Shoemaker, M. Ben, Weeke, Peter E., Pfeiffer, Ryan, Davies, Brianna, Andorin, Antoine, Hofman, Nynke, Dagradi, Federica, Pedrazzini, Matteo, Tester, David J., Bos, J. Martijn, Sarquella-Brugada, Georgia, Campuzano, Óscar, Platonov, Pyotr G., Stallmeyer, Birgit, Zumhagen, Sven, Nannenberg, Eline A., Veldink, Jan H., van den Berg, Leonard H., Al-Chalabi, Ammar, Shaw, Christopher E., Shaw, Pamela J., Morrison, Karen E., Andersen, Peter M., Müller-Nurasyid, Martina, Cusi, Daniele, Barlassina, Cristina, Galan, Pilar, Lathrop, Mark, Munter, Markus, Werge, Thomas, Ribasés, Marta, Aung, Tin, Khor, Chiea C., Ozaki, Mineo, Lichtner, Peter, Meitinger, Thomas, van Tintelen, J. Peter, Hoedemaekers, Yvonne, Denjoy, Isabelle, Leenhardt, Antoine, Napolitano, Carlo, Shimizu, Wataru, Schott, Jean-Jacques, Gourraud, Jean-Baptiste, Makiyama, Takeru, Ohno, Seiko, Itoh, Hideki, Krahn, Andrew D., Antzelevitch, Charles, Roden, Dan M., Saenen, Johan, Borggrefe, Martin, Odening, Katja E., Ellinor, Patrick T., Tfelt-Hansen, Jacob, Skinner, Jonathan R., van den Berg, Maarten P., Olesen, Morten Salling, Brugada, Josep, Brugada, Ramón, Makita, Naomasa, Breckpot, Jeroen, Yoshinaga, Masao, Behr, Elijah R., Rydberg, Annika, Aiba, Takeshi, Kääb, Stefan, Priori, Silvia G., Guicheney, Pascale, Tan, Hanno L., Newton-Cheh, Christopher, Ackerman, Michael J., Schwartz, Peter J., Schulze-Bahr, Eric, Probst, Vincent, Horie, Minoru, Wilde, Arthur A., Tanck, Michael W.T., and Bezzina, Connie R.

Published
2020
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164. Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Lieve, Krystien V.V., Dusi, Veronica, van der Werf, Christian, Bos, J. Martijn, Lane, Conor M., Stokke, Mathis Korseberg, Roston, Thomas M., Djupsjöbacka, Aurora, Wada, Yuko, Denjoy, Isabelle, Bundgaard, Henning, Noguer, Ferran Roses I., Semsarian, Christopher, Robyns, Tomas, Hofman, Nynke, Tanck, Michael W., van den Berg, Maarten P., Kammeraad, Janneke A.E., Krahn, Andrew D., Clur, Sally-Ann B., Sacher, Frederic, Till, Jan, Skinner, Jonathan R., Tfelt-Hansen, Jacob, Probst, Vincent, Leenhardt, Antoine, Horie, Minoru, Swan, Heikki, Roberts, Jason D., Sanatani, Shubhayan, Haugaa, Kristina H., Schwartz, Peter J., Ackerman, Michael J., and Wilde, Arthur A.M.

Published
2020
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166. Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility (Nature Genetics, (2022), 54, 3, (232-239), 10.1038/s41588-021-01007-6)

Author

Julien Barc, Barc, J, Tadros, R, Glinge, C, Chiang, D, Jouni, M, Simonet, F, Jurgens, S, Baudic, M, Nicastro, M, Potet, F, Offerhaus, J, Walsh, R, Hoan Choi, S, Verkerk, A, Mizusawa, Y, Anys, S, Minois, D, Arnaud, M, Duchateau, J, Wijeyeratne, Y, Muir, A, Papadakis, M, Castelletti, S, Torchio, M, Gil Ortuño, C, Lacunza, J, Giachino, D, Cerrato, N, Martins, R, Campuzano, O, Van Dooren, S, Thollet, A, Kyndt, F, Mazzanti, A, Clémenty, N, Bisson, A, Corveleyn, A, Stallmeyer, B, Dittmann, S, Saenen, J, Noël, A, Honarbakhsh, S, Rudic, B, Marzak, H, Rowe, M, Federspiel, C, Le Page, S, Placide, L, Milhem, A, Barajas-Martinez, H, Beckmann, B, Krapels, I, Steinfurt, J, Gregers Winkel, B, Jabbari, R, Shoemaker, M, Boukens, B, Škorić-Milosavljević, D, Bikker, H, Manevy, F, Lichtner, P, Ribasés, M, Meitinger, T, Müller-Nurasyid, M, Group, K, Veldink, J, van den Berg, L, Van Damme, P, Cusi, D, Lanzani, C, Rigade, S, Charpentier, E, Baron, E, Bonnaud, S, Lecointe, S, Donnart, A, Le Marec, H, Chatel, S, Karakachoff, M, Bézieau, S, London, B, Tfelt-Hansen, J, Roden, D, Odening, K, Cerrone, M, Chinitz, L, Volders, P, van de Berg, M, Laurent, G, Faivre, L, Antzelevitch, C, Kääb, S, Al Arnaout, A, Dupuis, J, Pasquie, J, Billon, O, Roberts, J, Jesel, L, Borggrefe, M, Lambiase, P, Mansourati, J, Loeys, B, Leenhardt, A, Guicheney, P, Maury, P, Schulze-Bahr, E, Robyns, T, Breckpot, J, Babuty, D, Priori, S, Napolitano, C, Referral Center for inherited cardiac arrhythmia, N, de Asmundis, C, Brugada, P, Brugada, R, Arbelo, E, Brugada, J, Mabo, P, Behar, N, Giustetto, C, Sabater Molina, M, Gimeno, J, Hasdemir, C, Schwartz, P, Crotti, L, Mckeown, P, Sharma, S, Behr, E, Haissaguerre, M, Sacher, F, Rooryck, C, Tan, H, Remme, C, Postema, P, Delmar, M, Ellinor, P, Lubitz, S, Gourraud, J, Tanck, M, L. George Jr., A, Macrae, C, Burridge, P, Dina, C, Probst, V, Wilde, A, Schott, J, Redon &amp, R, Bezzina, C, Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, Floriane Simonet, Sean J. Jurgens, Manon Baudic, Michele Nicastro, Franck Potet, Joost A. Offerhaus, Roddy Walsh, Seung Hoan Choi, Arie O. Verkerk, Yuka Mizusawa, Soraya Anys, Damien Minois, Marine Arnaud, Josselin Duchateau, Yanushi D. Wijeyeratne, Alison Muir, Michael Papadakis, Silvia Castelletti, Margherita Torchio, Cristina Gil Ortuño, Javier Lacunza, Daniela F. Giachino, Natascia Cerrato, Raphaël P. Martins, Oscar Campuzano, Sonia Van Dooren, Aurélie Thollet, Florence Kyndt, Andrea Mazzanti, Nicolas Clémenty, Arnaud Bisson, Anniek Corveleyn, Birgit Stallmeyer, Sven Dittmann, Johan Saenen, Antoine Noël, Shohreh Honarbakhsh, Boris Rudic, Halim Marzak, Matthew K. Rowe, Claire Federspiel, Sophie Le Page, Leslie Placide, Antoine Milhem, Hector Barajas-Martinez, Britt-Maria Beckmann, Ingrid P. Krapels, Johannes Steinfurt, Bo Gregers Winkel, Reza Jabbari, Moore B. Shoemaker, Bas J. Boukens, Doris Škorić-Milosavljević, Hennie Bikker, Federico Manevy, Peter Lichtner, Marta Ribasés, Thomas Meitinger, Martina Müller-Nurasyid, KORA-Study Group, Jan H. Veldink, Leonard H. van den Berg, Philip Van Damme, Daniele Cusi, Chiara Lanzani, Sidwell Rigade, Eric Charpentier, Estelle Baron, Stéphanie Bonnaud, Simon Lecointe, Audrey Donnart, Hervé Le Marec, Stéphanie Chatel, Matilde Karakachoff, Stéphane Bézieau, Barry London, Jacob Tfelt-Hansen, Dan Roden, Katja E. Odening, Marina Cerrone, Larry A. Chinitz, Paul G. Volders, Maarten P. van de Berg, Gabriel Laurent, Laurence Faivre, Charles Antzelevitch, Stefan Kääb, Alain Al Arnaout, Jean-Marc Dupuis, Jean-Luc Pasquie, Olivier Billon, Jason D. Roberts, Laurence Jesel, Martin Borggrefe, Pier D. Lambiase, Jacques Mansourati, Bart Loeys, Antoine Leenhardt, Pascale Guicheney, Philippe Maury, Eric Schulze-Bahr, Tomas Robyns, Jeroen Breckpot, Dominique Babuty, Silvia G. Priori, Carlo Napolitano, Nantes Referral Center for inherited cardiac arrhythmia, Carlo de Asmundis, Pedro Brugada, Ramon Brugada, Elena Arbelo, Josep Brugada, Philippe Mabo, Nathalie Behar, Carla Giustetto, Maria Sabater Molina, Juan R. Gimeno, Can Hasdemir, Peter J. Schwartz, Lia Crotti, Pascal P. McKeown, Sanjay Sharma, Elijah R. Behr, Michel Haissaguerre, Frédéric Sacher, Caroline Rooryck, Hanno L. Tan, Carol A. Remme, Pieter G. Postema, Mario Delmar, Patrick T. Ellinor, Steven A. Lubitz, Jean-Baptiste Gourraud, Michael W. Tanck, Alfred L. George Jr., Calum A. MacRae, Paul W. Burridge, Christian Dina, Vincent Probst, Arthur A. Wilde, Jean-Jacques Schott, Richard Redon &, Connie R. Bezzina, Julien Barc, Barc, J, Tadros, R, Glinge, C, Chiang, D, Jouni, M, Simonet, F, Jurgens, S, Baudic, M, Nicastro, M, Potet, F, Offerhaus, J, Walsh, R, Hoan Choi, S, Verkerk, A, Mizusawa, Y, Anys, S, Minois, D, Arnaud, M, Duchateau, J, Wijeyeratne, Y, Muir, A, Papadakis, M, Castelletti, S, Torchio, M, Gil Ortuño, C, Lacunza, J, Giachino, D, Cerrato, N, Martins, R, Campuzano, O, Van Dooren, S, Thollet, A, Kyndt, F, Mazzanti, A, Clémenty, N, Bisson, A, Corveleyn, A, Stallmeyer, B, Dittmann, S, Saenen, J, Noël, A, Honarbakhsh, S, Rudic, B, Marzak, H, Rowe, M, Federspiel, C, Le Page, S, Placide, L, Milhem, A, Barajas-Martinez, H, Beckmann, B, Krapels, I, Steinfurt, J, Gregers Winkel, B, Jabbari, R, Shoemaker, M, Boukens, B, Škorić-Milosavljević, D, Bikker, H, Manevy, F, Lichtner, P, Ribasés, M, Meitinger, T, Müller-Nurasyid, M, Group, K, Veldink, J, van den Berg, L, Van Damme, P, Cusi, D, Lanzani, C, Rigade, S, Charpentier, E, Baron, E, Bonnaud, S, Lecointe, S, Donnart, A, Le Marec, H, Chatel, S, Karakachoff, M, Bézieau, S, London, B, Tfelt-Hansen, J, Roden, D, Odening, K, Cerrone, M, Chinitz, L, Volders, P, van de Berg, M, Laurent, G, Faivre, L, Antzelevitch, C, Kääb, S, Al Arnaout, A, Dupuis, J, Pasquie, J, Billon, O, Roberts, J, Jesel, L, Borggrefe, M, Lambiase, P, Mansourati, J, Loeys, B, Leenhardt, A, Guicheney, P, Maury, P, Schulze-Bahr, E, Robyns, T, Breckpot, J, Babuty, D, Priori, S, Napolitano, C, Referral Center for inherited cardiac arrhythmia, N, de Asmundis, C, Brugada, P, Brugada, R, Arbelo, E, Brugada, J, Mabo, P, Behar, N, Giustetto, C, Sabater Molina, M, Gimeno, J, Hasdemir, C, Schwartz, P, Crotti, L, Mckeown, P, Sharma, S, Behr, E, Haissaguerre, M, Sacher, F, Rooryck, C, Tan, H, Remme, C, Postema, P, Delmar, M, Ellinor, P, Lubitz, S, Gourraud, J, Tanck, M, L. George Jr., A, Macrae, C, Burridge, P, Dina, C, Probst, V, Wilde, A, Schott, J, Redon &amp, R, Bezzina, C, Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, Floriane Simonet, Sean J. Jurgens, Manon Baudic, Michele Nicastro, Franck Potet, Joost A. Offerhaus, Roddy Walsh, Seung Hoan Choi, Arie O. Verkerk, Yuka Mizusawa, Soraya Anys, Damien Minois, Marine Arnaud, Josselin Duchateau, Yanushi D. Wijeyeratne, Alison Muir, Michael Papadakis, Silvia Castelletti, Margherita Torchio, Cristina Gil Ortuño, Javier Lacunza, Daniela F. Giachino, Natascia Cerrato, Raphaël P. Martins, Oscar Campuzano, Sonia Van Dooren, Aurélie Thollet, Florence Kyndt, Andrea Mazzanti, Nicolas Clémenty, Arnaud Bisson, Anniek Corveleyn, Birgit Stallmeyer, Sven Dittmann, Johan Saenen, Antoine Noël, Shohreh Honarbakhsh, Boris Rudic, Halim Marzak, Matthew K. Rowe, Claire Federspiel, Sophie Le Page, Leslie Placide, Antoine Milhem, Hector Barajas-Martinez, Britt-Maria Beckmann, Ingrid P. Krapels, Johannes Steinfurt, Bo Gregers Winkel, Reza Jabbari, Moore B. Shoemaker, Bas J. Boukens, Doris Škorić-Milosavljević, Hennie Bikker, Federico Manevy, Peter Lichtner, Marta Ribasés, Thomas Meitinger, Martina Müller-Nurasyid, KORA-Study Group, Jan H. Veldink, Leonard H. van den Berg, Philip Van Damme, Daniele Cusi, Chiara Lanzani, Sidwell Rigade, Eric Charpentier, Estelle Baron, Stéphanie Bonnaud, Simon Lecointe, Audrey Donnart, Hervé Le Marec, Stéphanie Chatel, Matilde Karakachoff, Stéphane Bézieau, Barry London, Jacob Tfelt-Hansen, Dan Roden, Katja E. Odening, Marina Cerrone, Larry A. Chinitz, Paul G. Volders, Maarten P. van de Berg, Gabriel Laurent, Laurence Faivre, Charles Antzelevitch, Stefan Kääb, Alain Al Arnaout, Jean-Marc Dupuis, Jean-Luc Pasquie, Olivier Billon, Jason D. Roberts, Laurence Jesel, Martin Borggrefe, Pier D. Lambiase, Jacques Mansourati, Bart Loeys, Antoine Leenhardt, Pascale Guicheney, Philippe Maury, Eric Schulze-Bahr, Tomas Robyns, Jeroen Breckpot, Dominique Babuty, Silvia G. Priori, Carlo Napolitano, Nantes Referral Center for inherited cardiac arrhythmia, Carlo de Asmundis, Pedro Brugada, Ramon Brugada, Elena Arbelo, Josep Brugada, Philippe Mabo, Nathalie Behar, Carla Giustetto, Maria Sabater Molina, Juan R. Gimeno, Can Hasdemir, Peter J. Schwartz, Lia Crotti, Pascal P. McKeown, Sanjay Sharma, Elijah R. Behr, Michel Haissaguerre, Frédéric Sacher, Caroline Rooryck, Hanno L. Tan, Carol A. Remme, Pieter G. Postema, Mario Delmar, Patrick T. Ellinor, Steven A. Lubitz, Jean-Baptiste Gourraud, Michael W. Tanck, Alfred L. George Jr., Calum A. MacRae, Paul W. Burridge, Christian Dina, Vincent Probst, Arthur A. Wilde, Jean-Jacques Schott, Richard Redon &, and Connie R. Bezzina

Abstract

In the version of this article initially published, Federico Manevy’s name appeared with a middle initial in error. The name has been corrected in the HTML and PDF versions of the article.

Published
2022

167. Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Author

Barc, J, Tadros, R, Glinge, C, Chiang, D, Jouni, M, Simonet, F, Jurgens, S, Baudic, M, Nicastro, M, Potet, F, Offerhaus, J, Walsh, R, Hoan Choi, S, Verkerk, A, Mizusawa, Y, Anys, S, Minois, D, Arnaud, M, Duchateau, J, Wijeyeratne, Y, Muir, A, Papadakis, M, Castelletti, S, Torchio, M, Gil Ortuño, C, Lacunza, J, Giachino, D, Cerrato, N, Martins, R, Campuzano, O, Van Dooren, S, Thollet, A, Kyndt, F, Mazzanti, A, Clémenty, N, Bisson, A, Corveleyn, A, Stallmeyer, B, Dittmann, S, Saenen, J, Noël, A, Honarbakhsh, S, Rudic, B, Marzak, H, Rowe, M, Federspiel, C, Le Page, S, Placide, L, Milhem, A, Barajas-Martinez, H, Beckmann, B, Krapels, I, Steinfurt, J, Gregers Winkel, B, Jabbari, R, Shoemaker, M, Boukens, B, Škorić-Milosavljević, D, Bikker, H, Manevy, F, Lichtner, P, Ribasés, M, Meitinger, T, Müller-Nurasyid, M, Group, K, Veldink, J, van den Berg, L, Van Damme, P, Cusi, D, Lanzani, C, Rigade, S, Charpentier, E, Baron, E, Bonnaud, S, Lecointe, S, Donnart, A, Le Marec, H, Chatel, S, Karakachoff, M, Bézieau, S, London, B, Tfelt-Hansen, J, Roden, D, Odening, K, Cerrone, M, Chinitz, L, Volders, P, van de Berg, M, Laurent, G, Faivre, L, Antzelevitch, C, Kääb, S, Al Arnaout, A, Dupuis, J, Pasquie, J, Billon, O, Roberts, J, Jesel, L, Borggrefe, M, Lambiase, P, Mansourati, J, Loeys, B, Leenhardt, A, Guicheney, P, Maury, P, Schulze-Bahr, E, Robyns, T, Breckpot, J, Babuty, D, Priori, S, Napolitano, C, Referral Center for inherited cardiac arrhythmia, N, de Asmundis, C, Brugada, P, Brugada, R, Arbelo, E, Brugada, J, Mabo, P, Behar, N, Giustetto, C, Sabater Molina, M, Gimeno, J, Hasdemir, C, Schwartz, P, Crotti, L, Mckeown, P, Sharma, S, Behr, E, Haissaguerre, M, Sacher, F, Rooryck, C, Tan, H, Remme, C, Postema, P, Delmar, M, Ellinor, P, Lubitz, S, Gourraud, J, Tanck, M, L. George Jr., A, Macrae, C, Burridge, P, Dina, C, Probst, V, Wilde, A, Schott, J, Redon &amp, R, Bezzina, C, Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, Floriane Simonet, Sean J. Jurgens, Manon Baudic, Michele Nicastro, Franck Potet, Joost A. Offerhaus, Roddy Walsh, Seung Hoan Choi, Arie O. Verkerk, Yuka Mizusawa, Soraya Anys, Damien Minois, Marine Arnaud, Josselin Duchateau, Yanushi D. Wijeyeratne, Alison Muir, Michael Papadakis, Silvia Castelletti, Margherita Torchio, Cristina Gil Ortuño, Javier Lacunza, Daniela F. Giachino, Natascia Cerrato, Raphaël P. Martins, Oscar Campuzano, Sonia Van Dooren, Aurélie Thollet, Florence Kyndt, Andrea Mazzanti, Nicolas Clémenty, Arnaud Bisson, Anniek Corveleyn, Birgit Stallmeyer, Sven Dittmann, Johan Saenen, Antoine Noël, Shohreh Honarbakhsh, Boris Rudic, Halim Marzak, Matthew K. Rowe, Claire Federspiel, Sophie Le Page, Leslie Placide, Antoine Milhem, Hector Barajas-Martinez, Britt-Maria Beckmann, Ingrid P. Krapels, Johannes Steinfurt, Bo Gregers Winkel, Reza Jabbari, Moore B. Shoemaker, Bas J. Boukens, Doris Škorić-Milosavljević, Hennie Bikker, Federico Manevy, Peter Lichtner, Marta Ribasés, Thomas Meitinger, Martina Müller-Nurasyid, KORA-Study Group, Jan H. Veldink, Leonard H. van den Berg, Philip Van Damme, Daniele Cusi, Chiara Lanzani, Sidwell Rigade, Eric Charpentier, Estelle Baron, Stéphanie Bonnaud, Simon Lecointe, Audrey Donnart, Hervé Le Marec, Stéphanie Chatel, Matilde Karakachoff, Stéphane Bézieau, Barry London, Jacob Tfelt-Hansen, Dan Roden, Katja E. Odening, Marina Cerrone, Larry A. Chinitz, Paul G. Volders, Maarten P. van de Berg, Gabriel Laurent, Laurence Faivre, Charles Antzelevitch, Stefan Kääb, Alain Al Arnaout, Jean-Marc Dupuis, Jean-Luc Pasquie, Olivier Billon, Jason D. Roberts, Laurence Jesel, Martin Borggrefe, Pier D. Lambiase, Jacques Mansourati, Bart Loeys, Antoine Leenhardt, Pascale Guicheney, Philippe Maury, Eric Schulze-Bahr, Tomas Robyns, Jeroen Breckpot, Dominique Babuty, Silvia G. Priori, Carlo Napolitano, Nantes Referral Center for inherited cardiac arrhythmia, Carlo de Asmundis, Pedro Brugada, Ramon Brugada, Elena Arbelo, Josep Brugada, Philippe Mabo, Nathalie Behar, Carla Giustetto, Maria Sabater Molina, Juan R. Gimeno, Can Hasdemir, Peter J. Schwartz, Lia Crotti, Pascal P. McKeown, Sanjay Sharma, Elijah R. Behr, Michel Haissaguerre, Frédéric Sacher, Caroline Rooryck, Hanno L. Tan, Carol A. Remme, Pieter G. Postema, Mario Delmar, Patrick T. Ellinor, Steven A. Lubitz, Jean-Baptiste Gourraud, Michael W. Tanck, Alfred L. George Jr., Calum A. MacRae, Paul W. Burridge, Christian Dina, Vincent Probst, Arthur A. Wilde, Jean-Jacques Schott, Richard Redon &, Connie R. Bezzina, Barc, J, Tadros, R, Glinge, C, Chiang, D, Jouni, M, Simonet, F, Jurgens, S, Baudic, M, Nicastro, M, Potet, F, Offerhaus, J, Walsh, R, Hoan Choi, S, Verkerk, A, Mizusawa, Y, Anys, S, Minois, D, Arnaud, M, Duchateau, J, Wijeyeratne, Y, Muir, A, Papadakis, M, Castelletti, S, Torchio, M, Gil Ortuño, C, Lacunza, J, Giachino, D, Cerrato, N, Martins, R, Campuzano, O, Van Dooren, S, Thollet, A, Kyndt, F, Mazzanti, A, Clémenty, N, Bisson, A, Corveleyn, A, Stallmeyer, B, Dittmann, S, Saenen, J, Noël, A, Honarbakhsh, S, Rudic, B, Marzak, H, Rowe, M, Federspiel, C, Le Page, S, Placide, L, Milhem, A, Barajas-Martinez, H, Beckmann, B, Krapels, I, Steinfurt, J, Gregers Winkel, B, Jabbari, R, Shoemaker, M, Boukens, B, Škorić-Milosavljević, D, Bikker, H, Manevy, F, Lichtner, P, Ribasés, M, Meitinger, T, Müller-Nurasyid, M, Group, K, Veldink, J, van den Berg, L, Van Damme, P, Cusi, D, Lanzani, C, Rigade, S, Charpentier, E, Baron, E, Bonnaud, S, Lecointe, S, Donnart, A, Le Marec, H, Chatel, S, Karakachoff, M, Bézieau, S, London, B, Tfelt-Hansen, J, Roden, D, Odening, K, Cerrone, M, Chinitz, L, Volders, P, van de Berg, M, Laurent, G, Faivre, L, Antzelevitch, C, Kääb, S, Al Arnaout, A, Dupuis, J, Pasquie, J, Billon, O, Roberts, J, Jesel, L, Borggrefe, M, Lambiase, P, Mansourati, J, Loeys, B, Leenhardt, A, Guicheney, P, Maury, P, Schulze-Bahr, E, Robyns, T, Breckpot, J, Babuty, D, Priori, S, Napolitano, C, Referral Center for inherited cardiac arrhythmia, N, de Asmundis, C, Brugada, P, Brugada, R, Arbelo, E, Brugada, J, Mabo, P, Behar, N, Giustetto, C, Sabater Molina, M, Gimeno, J, Hasdemir, C, Schwartz, P, Crotti, L, Mckeown, P, Sharma, S, Behr, E, Haissaguerre, M, Sacher, F, Rooryck, C, Tan, H, Remme, C, Postema, P, Delmar, M, Ellinor, P, Lubitz, S, Gourraud, J, Tanck, M, L. George Jr., A, Macrae, C, Burridge, P, Dina, C, Probst, V, Wilde, A, Schott, J, Redon &amp, R, Bezzina, C, Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, Floriane Simonet, Sean J. Jurgens, Manon Baudic, Michele Nicastro, Franck Potet, Joost A. Offerhaus, Roddy Walsh, Seung Hoan Choi, Arie O. Verkerk, Yuka Mizusawa, Soraya Anys, Damien Minois, Marine Arnaud, Josselin Duchateau, Yanushi D. Wijeyeratne, Alison Muir, Michael Papadakis, Silvia Castelletti, Margherita Torchio, Cristina Gil Ortuño, Javier Lacunza, Daniela F. Giachino, Natascia Cerrato, Raphaël P. Martins, Oscar Campuzano, Sonia Van Dooren, Aurélie Thollet, Florence Kyndt, Andrea Mazzanti, Nicolas Clémenty, Arnaud Bisson, Anniek Corveleyn, Birgit Stallmeyer, Sven Dittmann, Johan Saenen, Antoine Noël, Shohreh Honarbakhsh, Boris Rudic, Halim Marzak, Matthew K. Rowe, Claire Federspiel, Sophie Le Page, Leslie Placide, Antoine Milhem, Hector Barajas-Martinez, Britt-Maria Beckmann, Ingrid P. Krapels, Johannes Steinfurt, Bo Gregers Winkel, Reza Jabbari, Moore B. Shoemaker, Bas J. Boukens, Doris Škorić-Milosavljević, Hennie Bikker, Federico Manevy, Peter Lichtner, Marta Ribasés, Thomas Meitinger, Martina Müller-Nurasyid, KORA-Study Group, Jan H. Veldink, Leonard H. van den Berg, Philip Van Damme, Daniele Cusi, Chiara Lanzani, Sidwell Rigade, Eric Charpentier, Estelle Baron, Stéphanie Bonnaud, Simon Lecointe, Audrey Donnart, Hervé Le Marec, Stéphanie Chatel, Matilde Karakachoff, Stéphane Bézieau, Barry London, Jacob Tfelt-Hansen, Dan Roden, Katja E. Odening, Marina Cerrone, Larry A. Chinitz, Paul G. Volders, Maarten P. van de Berg, Gabriel Laurent, Laurence Faivre, Charles Antzelevitch, Stefan Kääb, Alain Al Arnaout, Jean-Marc Dupuis, Jean-Luc Pasquie, Olivier Billon, Jason D. Roberts, Laurence Jesel, Martin Borggrefe, Pier D. Lambiase, Jacques Mansourati, Bart Loeys, Antoine Leenhardt, Pascale Guicheney, Philippe Maury, Eric Schulze-Bahr, Tomas Robyns, Jeroen Breckpot, Dominique Babuty, Silvia G. Priori, Carlo Napolitano, Nantes Referral Center for inherited cardiac arrhythmia, Carlo de Asmundis, Pedro Brugada, Ramon Brugada, Elena Arbelo, Josep Brugada, Philippe Mabo, Nathalie Behar, Carla Giustetto, Maria Sabater Molina, Juan R. Gimeno, Can Hasdemir, Peter J. Schwartz, Lia Crotti, Pascal P. McKeown, Sanjay Sharma, Elijah R. Behr, Michel Haissaguerre, Frédéric Sacher, Caroline Rooryck, Hanno L. Tan, Carol A. Remme, Pieter G. Postema, Mario Delmar, Patrick T. Ellinor, Steven A. Lubitz, Jean-Baptiste Gourraud, Michael W. Tanck, Alfred L. George Jr., Calum A. MacRae, Paul W. Burridge, Christian Dina, Vincent Probst, Arthur A. Wilde, Jean-Jacques Schott, Richard Redon &, and Connie R. Bezzina

Abstract

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1.5, susceptibility genes remain largely unknown. Here we performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with BrS and 10,001 controls, and identified 21 association signals at 12 loci (10 new). Single nucleotide polymorphism (SNP)-heritability estimates indicate a strong polygenic influence. Polygenic risk score analyses based on the 21 susceptibility variants demonstrate varying cumulative contribution of common risk alleles among different patient subgroups, as well as genetic associations with cardiac electrical traits and disorders in the general population. The predominance of cardiac transcription factor loci indicates that transcriptional regulation is a key feature of BrS pathogenesis. Furthermore, functional studies conducted on MAPRE2, encoding the microtubule plus-end binding protein EB2, point to microtubule-related trafficking effects on NaV1.5 expression as a new underlying molecular mechanism. Taken together, these findings broaden our understanding of the genetic architecture of BrS and provide new insights into its molecular underpinnings.

Published
2022

171. Flecainide is associated with a reduction in arrhythmic events in a large cohort of patients with catecholaminergic polymorphic ventricular tachycardia

Author

Bergeman, A T, primary, Tanck, M W, additional, Kallas, D, additional, Sanatani, S, additional, Leenhardt, A, additional, Ackerman, M J, additional, Till, J, additional, Zorio, E, additional, Kannankeril, P J, additional, Kammeraad, J A E, additional, Aiba, T, additional, Semsarian, C, additional, Robyns, T, additional, Wilde, A A M, additional, and Van Der Werf, C, additional

Published
2023
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175. PO-04-139 THE CLINICAL COURSE OF GENOTYPE-POSITIVE PHENOTYPE-NEGATIVE PATIENTS WITH -MEDIATED CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA

Author

Peltenburg, Puck, primary, Perez, Guillermo J., additional, Till, Jan, additional, Sanatani, Shubhayan, additional, Swan, Heikki, additional, Zorio, Esther, additional, PROBST, VINCENT, additional, Haugaa, Kristina H., additional, Tfelt-Hansen, Jacob, additional, Blom, Nico A., additional, Clur, Sally-Ann B., additional, Leenhardt, Antoine, additional, Kammeraad, Janneke, additional, Ackerman, Michael J., additional, Brugada, Ramon, additional, Wilde, Arthur A., additional, and van der Werf, Christian, additional

Published
2023
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176. Differential Effect of Targeted Temperature Management Between 32 °C and 36 °C Following Cardiac Arrest According to Initial Severity of Illness

Author

Lascarrou, Jean Baptiste, primary, Dumas, Florence, additional, Bougouin, Wulfran, additional, Legriel, Stephane, additional, Aissaoui, Nadia, additional, Deye, Nicolas, additional, Beganton, Frankie, additional, Lamhaut, Lionel, additional, Jost, Daniel, additional, Vieillard-Baron, Antoine, additional, Nichol, Graham, additional, Marijon, Eloi, additional, Jouven, Xavier, additional, Cariou, Alain, additional, Adnet, F., additional, Agostinucci, J.M., additional, Aissaoui-Balanant, N., additional, Algalarrondo, V., additional, Alla, F., additional, Alonso, C., additional, Amara, W., additional, Annane, D., additional, Antoine, C., additional, Aubry, P., additional, Azoulay, E., additional, Beganton, F., additional, Billon, C., additional, Bougouin, W., additional, Boutet, J., additional, Bruel, C., additional, Bruneval, P., additional, Cariou, A., additional, Carli, P., additional, Casalino, E., additional, Cerf, C., additional, Chaib, A., additional, Cholley, B., additional, Cohen, Y., additional, Combes, A., additional, Coulaud, J.M., additional, Da Silva, D., additional, Das, V., additional, Demoule, A., additional, Denjoy, I., additional, Deye, N., additional, Diehl, J.L., additional, Dinanian, S., additional, Domanski, L., additional, Dreyfuss, D., additional, Dubois-Rande, J.L., additional, Dumas, F., additional, Duranteau, J., additional, Empana, J.P., additional, Extramiana, F., additional, Fagon, J.Y., additional, Fartoukh, M., additional, Fieux, F., additional, Gandjbakhch, E., additional, Geri, G., additional, Guidet, B., additional, Halimi, F., additional, Henry, P., additional, Jabre, P., additional, Joseph, L., additional, Jost, D., additional, Jouven, X., additional, Karam, N., additional, Lacotte, J., additional, Lahlou-Laforet, K., additional, Lamhaut, L., additional, Lanceleur, A., additional, Langeron, O., additional, Lavergne, T., additional, Lecarpentier, E., additional, Leenhardt, A., additional, Lellouche, N., additional, Lemiale, V., additional, Lemoine, F., additional, Linval, F., additional, Loeb, T., additional, Ludes, B., additional, Luyt, C.E., additional, Mansencal, N., additional, Mansouri, N., additional, Marijon, E., additional, Maury, E., additional, Maxime, V., additional, Megarbane, B., additional, Mekontso-Dessap, A., additional, Mentec, H., additional, Mira, J.P., additional, Monnet, X., additional, Narayanan, K., additional, Ngoyi, N., additional, Perier, M.C., additional, Piot, O., additional, Plaisance, P., additional, Plaud, B., additional, Plu, I., additional, Raphalen, J.H., additional, Raux, M., additional, Revaux, F., additional, Ricard, J.D., additional, Richard, C., additional, Riou, B., additional, Roussin, F., additional, Santoli, F., additional, Schortgen, F., additional, Sharshar, T., additional, Sideris, G., additional, Spaulding, C., additional, Teboul, J.L., additional, Timsit, J.F., additional, Tourtier, J.P., additional, Tuppin, P., additional, Ursat, C., additional, Varenne, O., additional, Vieillard-Baron, A., additional, Voicu, S., additional, Wahbi, K., additional, and Waldmann, V., additional

Published
2023
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177. Small-bowel capsule endoscopy in patients with Meckel’s diverticulum: clinical features, diagnostic workup, and findings. A European multicenter I-CARE study

Author

Baltes, Peter, primary, Dray, Xavier, additional, Riccioni, Maria Elena, additional, Pérez-Cuadrado-Robles, Enrique, additional, Fedorov, Evgeny, additional, Wiedbrauck, Felix, additional, Chetcuti Zammit, Stefania, additional, Cadoni, Sergio, additional, Bruno, Mauro, additional, Rondonotti, Emanuele, additional, Johansson, Gabriele Wurm, additional, Mussetto, Alessandro, additional, Beaumont, Hanneke, additional, Perrod, Guillaume, additional, McNamara, Deirdre, additional, Plevris, John, additional, Spada, Cristiano, additional, Pinho, Rolando, additional, Rosa, Bruno, additional, Hervas, Nerea, additional, Leenhardt, Romain, additional, Marmo, Clelia, additional, Esteban-Delgado, Pilar, additional, Ivanova, Ekaterina, additional, Keuchel, Martin, additional, Carretero, Cristina, additional, Tontini, Gian Eugenio, additional, Toth, Ervin, additional, Nemeth, Artur, additional, Sidhu, Reena, additional, Koulaouzidis, Anastasios, additional, Eliakim, Abraham, additional, Pennazio, Marco, additional, Tikhomirova, Ekaterina, additional, Zebski, Hubert, additional, Wulfert, Chris-Henrik, additional, Stachow, Florentin, additional, Janssen, Garrelt, additional, Carretero, C., additional, Tontini, E., additional, and Toth, E., additional

Published
2023
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183. Impacts des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques

Author

Leenhardt, Sophie, Mamy, Laure, Pesce, Stéphane, Sanchez, Wilfried, (coord.), Leenhardt, Sophie, Mamy, Laure, Pesce, Stéphane, Sanchez, Wilfried, and (coord.)

Abstract

Dans le cadre du plan Écophyto II+, la conduite d’une expertise scientifique collective sur les impacts des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques a été confiée, en 2020, à INRAE et à l’Ifremer. Les résultats, restitués en mai 2022, confirment que tous les types de milieux terrestres et aquatiques, l’ensemble des compartiments qui les composent et la plupart des organismes qui s’y trouvent sont contaminés par les produits phytopharmaceutiques. La contamination varie suivant l’éloignement des zones d’utilisation des produits, principalement agricoles. Elle engendre des impacts directs et indirects sur les écosystèmes, notamment le déclin des populations d’invertébrés terrestres et aquatiques et d’oiseaux, ainsi que l’altération de fonctions et services écosystémiques. Différents leviers contribuent à atténuer la contamination et ses impacts, avec une efficacité variable suivant leurs combinaisons (réglementation, conditions d’utilisation des produits…). Cette expertise identifie les besoins de recherche, en particulier pour mieux appréhender les phénomènes dynamiques dans un contexte de pressions multiples sur l’environnement. Il s’agira ainsi de caractériser et de prédire les impacts et d’améliorer les procédures d’évaluation des risques associés à l’utilisation des produits phytopharmaceutiques. Cet ouvrage s’adresse à l’ensemble des acteurs et décideurs concernés par les utilisations de produits phytopharmaceutiques, qu’ils interviennent dans le domaine juridique, politique, industriel, ou associatif, ainsi que dans la recherche ou l’enseignement.

Published
2023
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185. Pluridisciplinarité et interdisciplinarité au coeur de l’expertise scientifique collective INRAE et Ifremer sur les effets des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques

Author

Sanchez, Wilfried, Mamy, Laure, Pesce, Stéphane, Leenhardt, Sophie, Sanchez, Wilfried, Mamy, Laure, Pesce, Stéphane, and Leenhardt, Sophie

Abstract

Pluridisciplinarity and interdisciplinarity at the heart of the INRAE and Ifremer collective scientific assessment on the effects of plant protection products on biodiversity and ecosystem services. A collective scientific assessment on the effects of plant protection products on biodiversity and ecosystem services conducted jointly by INRAE and Ifremer within the framework of the Écophyto 2+ programme mobilised a multidisciplinary panel of 46 French-speaking scientific experts for two years. This work, based on the analysis of more than 4 000 scientific articles, showed that plant protection products contaminate all environments, especially agricultural areas, that they are responsible, through direct and indirect effects, for the decline of certain taxonomic groups such as terrestrial and aquatic invertebrates and birds, and that the combination of different levers can reduce this contamination and the associated effects. It identifies several gaps of knowledge related to the occurrence and effects of metabolites as well as effects on marine and overseas biodiversity. This assessment highlights the value of multidisciplinary approaches to address complex issues such as the effects of plant protection products. It also highlights the role of concepts such as ecosystem services or the regulation of the marketing of chemical substances in facilitating the rapprochement between environmental sciences and human and social sciences., Une expertise scientifique collective menée conjointement par INRAE et l’Ifremer dans le cadre du plan Écophyto 2þa mobilisé, pendant 2 ans, un panel pluridisciplinaire francophone de 46 experts scientifiques. Ce travail, basé sur l’analyse de plus de 4 000 références bibliographiques, a mis en évidence que les produits phytopharmaceutiques contaminent tous les milieux, majoritairement les zones agricoles, qu’ils sont responsables, par des effets directs et indirects, du déclin de certains groupes taxonomiques tels que les invertébrés terrestres et aquatiques et les oiseaux, et que la combinaison de différents leviers peut réduire cette contamination et les effets associés. La robustesse des conclusions de cette étude justifie l’intérêt d’approches combinant des disciplines variées dans le domaine des sciences de l’environnement mais aussi des sciences humaines et sociales

Published
2023
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186. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Bergeman, Auke T., Lieve, Krystien V.V., Kallas, Dania, Bos, J. Martijn, Rosés I Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke A.E., Peltenburg, Puck J., Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan S., Brugada, Ramon, Borggrefe, Martin, Clur, Sally Ann B., Cox, Moniek G.P.J., Davis, Andrew, Dhillon, Santokh, Etheridge, Susan P., Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin M., Krause, Ulrich, Kwok, Sit Yee, Lapage, Martin J., Ohno, Seiko, Probst, Vincent, Roberts, Jason D., Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan R., Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing Chien, Kannankeril, Prince J., Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael W.T., Ackerman, Michael J., Wilde, Arthur A.M., Van Der Werf, Christian, Bergeman, Auke T., Lieve, Krystien V.V., Kallas, Dania, Bos, J. Martijn, Rosés I Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke A.E., Peltenburg, Puck J., Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan S., Brugada, Ramon, Borggrefe, Martin, Clur, Sally Ann B., Cox, Moniek G.P.J., Davis, Andrew, Dhillon, Santokh, Etheridge, Susan P., Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin M., Krause, Ulrich, Kwok, Sit Yee, Lapage, Martin J., Ohno, Seiko, Probst, Vincent, Roberts, Jason D., Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan R., Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing Chien, Kannankeril, Prince J., Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael W.T., Ackerman, Michael J., Wilde, Arthur A.M., and Van Der Werf, Christian

Abstract

BACKGROUND: In severely affected patients with catecholaminergic polymorphic ventricular tachycardia, beta-blockers are often insufficiently protective. The purpose of this study was to evaluate whether flecainide is associated with a lower incidence of arrhythmic events (AEs) when added to beta-blockers in a large cohort of patients with catecholaminergic polymorphic ventricular tachycardia. METHODS: From 2 international registries, this multicenter case cross-over study included patients with a clinical or genetic diagnosis of catecholaminergic polymorphic ventricular tachycardia in whom flecainide was added to beta-blocker therapy. The study period was defined as the period in which background therapy (ie, beta-blocker type [beta1-selective or nonselective]), left cardiac sympathetic denervation, and implantable cardioverter defibrillator treatment status, remained unchanged within individual patients and was divided into pre-flecainide and on-flecainide periods. The primary end point was AEs, defined as sudden cardiac death, sudden cardiac arrest, appropriate implantable cardioverter defibrillator shock, and arrhythmic syncope. The association of flecainide with AE rates was assessed using a generalized linear mixed model assuming negative binomial distribution and random effects for patients. RESULTS: A total of 247 patients (123 [50%] females; median age at start of flecainide, 18 years [interquartile range, 14-29]; median flecainide dose, 2.2 mg/kg per day [interquartile range, 1.7-3.1]) were included. At baseline, all patients used a beta-blocker, 70 (28%) had an implantable cardioverter defibrillator, and 21 (9%) had a left cardiac sympathetic denervation. During a median pre-flecainide follow-up of 2.1 years (interquartile range, 0.4-7.2), 41 patients (17%) experienced 58 AEs (annual event rate, 5.6%). During a median on-flecainide follow-up of 2.9 years (interquartile range, 1.0-6.0), 23 patients (9%) experienced 38 AEs (annual event rate, 4.0%). There

Published
2023

187. Characteristics of specialists treating hypothyroid patients:the “THESIS” collaborative

Author

Žarković, Miloš, Attanasio, Roberto, Nagy, Endre V., Negro, Roberto, Papini, Enrico, Perros, Petros, Cohen, Chagit Adler, Akarsu, Ersin, Alevizaki, Maria, Ayvaz, Göksun, Bednarczuk, Tomasz, Berta, Eszter, Bodor, Miklos, Borissova, Anna Maria, Boyanov, Mihail, Buffet, Camille, Burlacu, Maria Cristina, Ćirić, Jasmina, Díez, Juan J., Dobnig, Harald, Fadeyev, Valentin, Field, Benjamin C.T., Fliers, Eric, Frølich, Jacob Stampe, Führer, Dagmar, Galofré, Juan Carlos, Hakala, Tommi, Jiskra, Jan, Kopp, Peter, Krebs, Michael, Kršek, Michal, Kužma, Martin, Lantz, Mikael, Lazúrová, Ivica, Leenhardt, Laurence, Luchytskiy, Vitaliy, McGowan, Anne, Melo, Miguel, Metso, Saara, Moran, Carla, Morgunova, Tatyana, Mykola, Tronko, Beleslin, Biljana Nedeljković, Niculescu, Dan Alexandru, Perić, Božidar, Planck, Tereza, Poiana, Catalina, Puga, Francisca Marques, Robenshtok, Eyal, Rosselet, Patrick, Ruchala, Marek, Riis, Kamilla Ryom, Shepelkevich, Alla, Unuane, David, Vardarli, Irfan, Visser, W. Edward, Vrionidou, Andromachi, Younes, Younes R., Yurenya, Elena, Hegedüs, Laszlo, Žarković, Miloš, Attanasio, Roberto, Nagy, Endre V., Negro, Roberto, Papini, Enrico, Perros, Petros, Cohen, Chagit Adler, Akarsu, Ersin, Alevizaki, Maria, Ayvaz, Göksun, Bednarczuk, Tomasz, Berta, Eszter, Bodor, Miklos, Borissova, Anna Maria, Boyanov, Mihail, Buffet, Camille, Burlacu, Maria Cristina, Ćirić, Jasmina, Díez, Juan J., Dobnig, Harald, Fadeyev, Valentin, Field, Benjamin C.T., Fliers, Eric, Frølich, Jacob Stampe, Führer, Dagmar, Galofré, Juan Carlos, Hakala, Tommi, Jiskra, Jan, Kopp, Peter, Krebs, Michael, Kršek, Michal, Kužma, Martin, Lantz, Mikael, Lazúrová, Ivica, Leenhardt, Laurence, Luchytskiy, Vitaliy, McGowan, Anne, Melo, Miguel, Metso, Saara, Moran, Carla, Morgunova, Tatyana, Mykola, Tronko, Beleslin, Biljana Nedeljković, Niculescu, Dan Alexandru, Perić, Božidar, Planck, Tereza, Poiana, Catalina, Puga, Francisca Marques, Robenshtok, Eyal, Rosselet, Patrick, Ruchala, Marek, Riis, Kamilla Ryom, Shepelkevich, Alla, Unuane, David, Vardarli, Irfan, Visser, W. Edward, Vrionidou, Andromachi, Younes, Younes R., Yurenya, Elena, and Hegedüs, Laszlo

Abstract

Introduction: Thyroid specialists influence how hypothyroid patients are treated, including patients managed in primary care. Given that physician characteristics influence patient care, this study aimed to explore thyroid specialist profiles and associations with geo-economic factors. Methods: Thyroid specialists from 28 countries were invited to respond to a questionnaire, Treatment of Hypothyroidism in Europe by Specialists: an International Survey (THESIS). Geographic regions were defined according to the United Nations Statistics Division. The national economic status was estimated using World Bank data on the gross national income per capita (GNI per capita). Results: 5,695 valid responses were received (response rate 33·0%). The mean age was 49 years, and 65·0% were female. The proportion of female respondents was lowest in Northern (45·6%) and highest in Eastern Europe (77·2%) (p <0·001). Respondent work volume, university affiliation and private practice differed significantly between countries (p<0·001). Age and GNI per capita were correlated inversely with the proportion of female respondents (p<0·01). GNI per capita was inversely related to the proportion of respondents working exclusively in private practice (p<0·011) and the proportion of respondents who treated >100 patients annually (p<0·01). Discussion: THESIS has demonstrated differences in characteristics of thyroid specialists at national and regional levels, strongly associated with GNI per capita. Hypothyroid patients in middle-income countries are more likely to encounter female thyroid specialists working in private practice, with a high workload, compared to high-income countries. Whether these differences influence the quality of care and patient satisfaction is unknown, but merits further study.

Published
2023

188. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS.

Author

Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frédéric, Mabo, Philippe, Kim, SungHwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi YD, Mazzanti, Andrea, Brugada, Ramon, Casado Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah Raphael, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo KF, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frédéric, Mabo, Philippe, Kim, SungHwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi YD, Mazzanti, Andrea, Brugada, Ramon, Casado Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah Raphael, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo KF, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

189. Small-bowel capsule endoscopy in patients with Meckel's diverticulum: clinical features, diagnostic workup, and findings. A European multicenter I-CARE study

Author

Baltes, P., Dray, X., Riccioni, Maria Elena, Perez-Cuadrado-Robles, E., Fedorov, E., Wiedbrauck, F., Chetcuti Zammit, S., Cadoni, S., Bruno, M., Rondonotti, E., Johansson, G. W., Mussetto, A., Beaumont, H., Perrod, G., Mcnamara, D., Plevris, J., Spada, Cristiano, Pinho, R., Rosa, B., Hervas, N., Leenhardt, R., Marmo, Clelia, Esteban-Delgado, P., Ivanova, E., Keuchel, M., Carretero, C., Tontini, G. E., Toth, E., Nemeth, A., Sidhu, R., Koulaouzidis, A., Eliakim, A., Pennazio, M., Tikhomirova, E., Zebski, H., Wulfert, C. -H., Stachow, F., Janssen, G., Tontini, E., Riccioni M. E. (ORCID:0000-0002-9239-4312), Spada C. (ORCID:0000-0002-5692-0960), Marmo C., Baltes, P., Dray, X., Riccioni, Maria Elena, Perez-Cuadrado-Robles, E., Fedorov, E., Wiedbrauck, F., Chetcuti Zammit, S., Cadoni, S., Bruno, M., Rondonotti, E., Johansson, G. W., Mussetto, A., Beaumont, H., Perrod, G., Mcnamara, D., Plevris, J., Spada, Cristiano, Pinho, R., Rosa, B., Hervas, N., Leenhardt, R., Marmo, Clelia, Esteban-Delgado, P., Ivanova, E., Keuchel, M., Carretero, C., Tontini, G. E., Toth, E., Nemeth, A., Sidhu, R., Koulaouzidis, A., Eliakim, A., Pennazio, M., Tikhomirova, E., Zebski, H., Wulfert, C. -H., Stachow, F., Janssen, G., Tontini, E., Riccioni M. E. (ORCID:0000-0002-9239-4312), Spada C. (ORCID:0000-0002-5692-0960), and Marmo C.

Abstract

Background and Aims: Meckel's diverticulum (MD) may remain silent or be associated with adverse events such as GI bleeding. The main aim of this study was to evaluate indicative small-bowel capsule endoscopy (SBCE) findings, and the secondary aim was to describe clinical presentation in patients with MD. Methods: This retrospective European multicenter study included patients with MD undergoing SBCE from 2001 until July 2021. Results: Sixty-nine patients with a confirmed MD were included. Median age was 32 years with a male-to-female ratio of approximately 3:1. GI bleeding or iron-deficiency anemia was present in nearly all patients. Mean hemoglobin was 7.63 ± 1.8 g/dL with a transfusion requirement of 52.2%. Typical capsule endoscopy (CE) findings were double lumen (n = 49 [71%]), visible entrance into the MD (n = 49 [71%]), mucosal webs (n = 30 [43.5%]), and bulges (n = 19 [27.5%]). Two or more of these findings were seen in 48 patients (69.6%). Ulcers were detected in 52.2% of patients (n = 36). In 63.8% of patients (n = 44), a combination of double lumen and visible entrance into the MD was evident, additionally revealing ulcers in 39.1% (n = 27). Mean percent SB (small bowel) transit time for the first indicative image of MD was 57% of the total SB transit time. Conclusions: Diagnosis of MD is rare and sometimes challenging, and a preoperative criterion standard does not exist. In SBCE, the most frequent findings were double-lumen sign and visible diverticular entrance, sometimes together with ulcers.

Published
2023

190. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram:Sub-Analysis From the SABRUS

Author

Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Published
2023

191. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Bergeman, Auke T, Lieve, Krystien V V, Kallas, Dania, Bos, J Martijn, Rosés I Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke A E, Peltenburg, Puck J, Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan S, Brugada, Ramon, Borggrefe, Martin, Clur, Sally-Ann B, Cox, Moniek G P J, Davis, Andrew, Dhillon, Santokh, Etheridge, Susan P, Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin M, Krause, Ulrich, Kwok, Sit-Yee, LaPage, Martin J, Ohno, Seiko, Probst, Vincent, Roberts, Jason D, Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan R, Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing-Chien, Kannankeril, Prince J, Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael W T, Ackerman, Michael J, Wilde, Arthur A M, van der Werf, Christian, Bergeman, Auke T, Lieve, Krystien V V, Kallas, Dania, Bos, J Martijn, Rosés I Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke A E, Peltenburg, Puck J, Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan S, Brugada, Ramon, Borggrefe, Martin, Clur, Sally-Ann B, Cox, Moniek G P J, Davis, Andrew, Dhillon, Santokh, Etheridge, Susan P, Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin M, Krause, Ulrich, Kwok, Sit-Yee, LaPage, Martin J, Ohno, Seiko, Probst, Vincent, Roberts, Jason D, Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan R, Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing-Chien, Kannankeril, Prince J, Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael W T, Ackerman, Michael J, Wilde, Arthur A M, and van der Werf, Christian

Abstract

BACKGROUND: In severely affected patients with catecholaminergic polymorphic ventricular tachycardia, beta-blockers are often insufficiently protective. The purpose of this study was to evaluate whether flecainide is associated with a lower incidence of arrhythmic events (AEs) when added to beta-blockers in a large cohort of patients with catecholaminergic polymorphic ventricular tachycardia.METHODS: From 2 international registries, this multicenter case cross-over study included patients with a clinical or genetic diagnosis of catecholaminergic polymorphic ventricular tachycardia in whom flecainide was added to beta-blocker therapy. The study period was defined as the period in which background therapy (ie, beta-blocker type [beta1-selective or nonselective]), left cardiac sympathetic denervation, and implantable cardioverter defibrillator treatment status, remained unchanged within individual patients and was divided into pre-flecainide and on-flecainide periods. The primary end point was AEs, defined as sudden cardiac death, sudden cardiac arrest, appropriate implantable cardioverter defibrillator shock, and arrhythmic syncope. The association of flecainide with AE rates was assessed using a generalized linear mixed model assuming negative binomial distribution and random effects for patients.RESULTS: A total of 247 patients (123 [50%] females; median age at start of flecainide, 18 years [interquartile range, 14-29]; median flecainide dose, 2.2 mg/kg per day [interquartile range, 1.7-3.1]) were included. At baseline, all patients used a beta-blocker, 70 (28%) had an implantable cardioverter defibrillator, and 21 (9%) had a left cardiac sympathetic denervation. During a median pre-flecainide follow-up of 2.1 years (interquartile range, 0.4-7.2), 41 patients (17%) experienced 58 AEs (annual event rate, 5.6%). During a median on-flecainide follow-up of 2.9 years (interquartile range, 1.0-6.0), 23 patients (9%) experienced 38 AEs (annual event rate

Published
2023

193. Résoudre les déséquilibres en eau des territoires agricoles : l'efficacité et l'acceptabilité sociale de quatre scénarios à l'épreuve d'un cas d'étude

Author

S. ALLAIN, G. PLUMECOQ, and D. BURGER-LEENHARDT

Subjects
Environmental technology. Sanitary engineering, TD1-1066, Environmental sciences, GE1-350
Abstract

En été, certains territoires agricoles sont confrontés de manière récurrente à un déséquilibre hydrique, conduisant les services de l'État à limiter les prélèvements d'eau. C'est dans ce contexte qu'ont été mis en œuvre en 2015 les projets de territoire, qui encouragent une politique conjointe de stockage de substitution et d'économies d'eau, en concertation avec tous les acteurs. Dans quelle mesure cette politique est-elle efficace pour atteindre l'équilibre quantitatif ? Pour y répondre, les auteurs de cet article s'appuient sur les résultats d'une simulation de scénarios de gestion de l'eau évalués et commentés par des acteurs de l'eau.

Published
2019
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194. Nomenclature and semantic description of vascular lesions in small bowel capsule endoscopy: an international Delphi consensus statement

Author

Romain Leenhardt, Cynthia Li, Anastasios Koulaouzidis, Flaminia Cavallaro, Franck Cholet, Rami Eliakim, Ignacio Fernandez-Urien, Uri Kopylov, Mark McAlindon, Artur Németh, John N. Plevris, Gabriel Rahmi, Emanuele Rondonotti, Jean-Christophe Saurin, Gian Eugenio Tontini, Ervin Toth, Diana Yung, Philippe Marteau, and Xavier Dray

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and study aims Nomenclature and descriptions of small bowel (SB) vascular lesions in capsule endoscopy (CE) are scarce in the medical literature. They are mostly based on the reader's opinion and thus differ between experts, with a potential negative impact on clinical care, teaching and research regarding SBCE. Our aim was to better define a nomenclature and to give a description of the most frequent vascular lesions in SBCE. Methods A panel of 18 European expert SBCE readers was formed during the UEGW 2016 meeting. Three experts constructed an Internet-based four-round Delphi consensus, but did not participate in the voting process. They built questionnaires that included various still frames of vascular lesions obtained with a third-generation SBCE system. The 15 remaining participants were asked to rate different proposals and description of the most common SB vascular lesions. A 6-point rating scale (varying from ‘strongly disagree’ to ‘strongly agree’) was used successive rounds. The consensus was reached when at least 80 % voting members scored the statement within the ‘agree’ or ‘strongly agree’. Results Consensual terms and descriptions were reached for angiectasia/angiodysplasia, erythematous patch, red spot/dot, and phlebectasia. A consensual description was reached for more subtle vascular lesions tentatively named “diminutive angiectasia” but no consensus was reached for this term. Conclusion An international group has reached a consensus on the nomenclature and descriptions of the most frequent and relevant SB vascular lesions in CE. These terms and descriptions are useful in daily practice, for teaching and for medical research purposes.

Published
2019
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198. Flecainide is associated with a reduction in arrhythmic events in a large cohort of patients with catecholaminergic polymorphic ventricular tachycardia

Author

A T Bergeman, M W Tanck, D Kallas, S Sanatani, A Leenhardt, M J Ackerman, J Till, E Zorio, P J Kannankeril, J A E Kammeraad, T Aiba, C Semsarian, T Robyns, A A M Wilde, and C Van Der Werf

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This work was supported by the ZonMW Priority Medicines for Rare Diseases and Orphan Drugs (grant 113304045 to Dr Van der Werf) and the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centres, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (PREDICT2 to Dr. Wilde). Background In patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), β-blocker may be insufficiently protective. A randomized clinical trial showed that flecainide reduces ventricular arrhythmias (VAs) in CPVT and small retrospective cohort studies suggest that this translates into a reduction of arrhythmic events. Objective To evaluate the efficacy of flecainide when added to β-blockers for the prevention of arrhythmic events (AE) in a large cohort of patients with CPVT using paired analysis. Methods From two international registries, this multicentre retrospective cohort study included patients with a clinical and/or genetic diagnosis of CPVT using flecainide as an adjunct to β-blockers. The study period, which comprised a pre- and on-flecianide period, was defined as the period in which background therapy, i.e. β-blocker type (β1-selective or nonselective), left cardiac sympathetic denervation (LCSD), and implantable cardioverter-defibrillator (ICD) treatment status, remained unchanged within individual patients. The primary endpoint was AEs, defined as SCD, sudden cardiac arrest (SCA), appropriate ICD shock, and arrhythmic syncope. The effect of flecainide on AE rates was assessed using a generalized linear mixed model assuming Poisson distribution and random effects for patients. Results Two-hundred forty-seven patients (median age at start of flecainide 18 years [IQR 14-29], 123 [50%] female, median flecainide dose 2.2 mg/kg/day [IQR 1.7-3.1]) were included. At baseline, 70 (28%) patients had an ICD and 21 (9%) had a LCSD performed. Nonselective β-blockers were used by 133 (54%) patients. During a median pre-flecainide follow-up of 2.1 years (IQR 0.4-7.2), 41 patients experienced 58 AEs. During a median on-flecainide follow-up of 2.9 years (IQR 1.0-6.0), 23 patients experienced 38 AEs. There was a significant reduction in AEs after initiation of flecainide (OR 0.55 [0.38-0.83]; p=0.007). Among patients who were symptomatic before diagnosis or before the initiation of flecainide (n=167), flecainide was associated with a significant reduction in AEs (OR 0.49 [0.31-0.77]; p=0.002). Among patients with ≥1 AE on β-blocker therapy (n=41), adding flecainide was associated with a significant reduction in AEs (OR 0.25 [0.14-0.45]; p Conclusion Flecainide was associated with a reduction in AEs when added to β-blockers in patients with CPVT in the overall cohort, symptomatic patients, and particularly in patients with breakthrough AEs on β-blocker therapy.

Published
2023

199. Catchment-scale analysis of hydrological and agricultural impacts of small reservoirs

Author

Jérôme Molénat, Cecile Dagés, Nicolas Lebon, and Delphine Leenhardt

Abstract

Small reservoirs are dams built to intercept and store runoff water. Small reservoirs can be a resource for farmers by providing water for crop irrigation. In agricultural areas, small reservoirs are seen as a way to sustain agriculture in times of drought. Changes in rainfall patterns due to climate change, with higher rainfall in some seasons and longer droughts in others, and the need to maintain or even increase agricultural productivity are also prompting some stakeholders to promote the development of small reservoirs. The proliferation of small reservoirs in a catchment can put pressure on the water cycle and have a cumulative impact on river flows and other hydrological components, which in turn can affect other water uses and the quality of downstream aquatic environments (Habets et al., 2018). There is a need to better understand and quantify both the cumulative hydrological impacts and the agricultural benefits of small reservoirs. We present here an analysis of the cumulative impact of small reservoirs on hydrology and crop yield in an agricultural catchment. This analysis is based on the modeling of a 20 km² catchment in southwestern France. We used a new agro-hydrological model called Mhydas-Small-Reservoirs, a model coupling hydrological and crop processes with farmers' water management decisions (Lebon et al., 2022). Several catchment situations were considered. These situations combine different levels of reservoir use (current situation with 26 reservoirs of which only 13 are exploited for crop irrigation, a situation with no reservoirs at all, a situation where reservoirs currently not exploited are used for irrigation) and different climatic years (dry year, wet year, and year with average rainfall). The simulations were analyzed in terms of crop yields and different water balance terms (flow, ET, irrigation withdrawal). From the preliminary results, we show the interest and the need to take into account the interactions between hydrological and agricultural processes to quantify the impacts due to small reservoirs. We also identify the need for observations in agrohydrological modeling applied to catchments with small reservoirs. References Habets F., Molénat J., Carluer N., Douez O., Leenhardt D., 2018, The cumulative impacts of small reservoirs on hydrology: A review, Science of The Total Environment, 643, 850-867, https://doi.org/10.1016/j.scitotenv.2018.06.188 Lebon, N., Dagès, C., Burger-Leenhardt, D., Molénat, J. 2022, A new agro-hydrological catchment model to assess the cumulative impact of small reservoirs, Environmental Modelling & Software, Volume 153,2022, 105409, https://doi.org/10.1016/j.envsoft.2022.105409

Published
2023

200. Small-bowel capsule endoscopy in patients with Meckel's diverticulum: clinical features, diagnostic workup, and findings. A European multicenter I-CARE study

Author

Peter Baltes, Xavier Dray, Maria Elena Riccioni, Enrique Pérez-Cuadrado-Robles, Evgeny Fedorov, Felix Wiedbrauck, Stefania Chetcuti Zammit, Sergio Cadoni, Mauro Bruno, Emanuele Rondonotti, Gabriele Wurm Johansson, Alessandro Mussetto, Hanneke Beaumont, Guillaume Perrod, Deirdre McNamara, John Plevris, Cristiano Spada, Rolando Pinho, Bruno Rosa, Nerea Hervas, Romain Leenhardt, Clelia Marmo, Pilar Esteban-Delgado, Ekaterina Ivanova, Martin Keuchel, Cristina Carretero, Gian Eugenio Tontini, Ervin Toth, Artur Nemeth, Reena Sidhu, Anastasios Koulaouzidis, Abraham Eliakim, Marco Pennazio, Ekaterina Tikhomirova, Hubert Zebski, Chris-Henrik Wulfert, Florentin Stachow, Garrelt Janssen, C. Carretero, E. Tontini, E. Toth, and Gastroenterology and hepatology

Subjects
Small-bowel capsule endoscopy, Meckel's diverticulum, Small-bowel capsule endoscopy, Meckel's diverticulum, Settore MED/12 - GASTROENTEROLOGIA, Gastroenterology, Radiology, Nuclear Medicine and imaging
Abstract

Background and Aims: Meckel's diverticulum (MD) may remain silent or be associated with adverse events such as GI bleeding. The main aim of this study was to evaluate indicative small-bowel capsule endoscopy (SBCE) findings, and the secondary aim was to describe clinical presentation in patients with MD. Methods: This retrospective European multicenter study included patients with MD undergoing SBCE from 2001 until July 2021. Results: Sixty-nine patients with a confirmed MD were included. Median age was 32 years with a male-to-female ratio of approximately 3:1. GI bleeding or iron-deficiency anemia was present in nearly all patients. Mean hemoglobin was 7.63 ± 1.8 g/dL with a transfusion requirement of 52.2%. Typical capsule endoscopy (CE) findings were double lumen (n = 49 [71%]), visible entrance into the MD (n = 49 [71%]), mucosal webs (n = 30 [43.5%]), and bulges (n = 19 [27.5%]). Two or more of these findings were seen in 48 patients (69.6%). Ulcers were detected in 52.2% of patients (n = 36). In 63.8% of patients (n = 44), a combination of double lumen and visible entrance into the MD was evident, additionally revealing ulcers in 39.1% (n = 27). Mean percent SB (small bowel) transit time for the first indicative image of MD was 57% of the total SB transit time. Conclusions: Diagnosis of MD is rare and sometimes challenging, and a preoperative criterion standard does not exist. In SBCE, the most frequent findings were double-lumen sign and visible diverticular entrance, sometimes together with ulcers.

Published
2023

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