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151. Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal

Author

Nabuurs, Cindy H., Kievit, Wietske, Leemans, C. René, Smit, Conrad F.G.M., van den Brekel, Michiel W.M., Pauw, Robert J., van der Laan, Bernard F.A.M., Jansen, Jeroen C., Lacko, Martin, Braunius, Weibel W., Dai, Chunfu, Shi, Xunbei, Danesi, Giovanni, Bouček, Jan, Takes, Robert P., Kunst, Henricus P.M., Nabuurs, Cindy H., Kievit, Wietske, Leemans, C. René, Smit, Conrad F.G.M., van den Brekel, Michiel W.M., Pauw, Robert J., van der Laan, Bernard F.A.M., Jansen, Jeroen C., Lacko, Martin, Braunius, Weibel W., Dai, Chunfu, Shi, Xunbei, Danesi, Giovanni, Bouček, Jan, Takes, Robert P., and Kunst, Henricus P.M.

Abstract

Background: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti. Methods: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated. Results: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass. Conclusion: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.

Published
2022

152. Caregiver Burden, Psychological Distress and Quality of Life among Informal Caregivers of Patients with Head and Neck Cancer:A Longitudinal Study

Author

Van Hof, Kira S., Hoesseini, Arta, Dorr, Maarten C., Verdonck-de Leeuw, Irma M., Jansen, Femke, Leemans, C. René, Takes, Robert P., Terhaard, Chris H.J., Baatenburg de Jong, Robert Jan, Sewnaik, Aniel, Offerman, Marinella P.J., Van Hof, Kira S., Hoesseini, Arta, Dorr, Maarten C., Verdonck-de Leeuw, Irma M., Jansen, Femke, Leemans, C. René, Takes, Robert P., Terhaard, Chris H.J., Baatenburg de Jong, Robert Jan, Sewnaik, Aniel, and Offerman, Marinella P.J.

Abstract

(1) Background: The aim of this study was to investigate caregiver burden among informal caregivers of head and neck cancer patients, in relation to distress and quality of life (QoL), and the relationship between informal caregivers and patients. (2) Methods: Data of 234 dyads from the multicenter prospective cohort study Netherlands Quality of life and Biomedical Cohort studies in cancer was used. Caregiver burden, psychological distress, global QoL, physical and social functioning were measured from baseline until 24 months after treatment. (4) Conclusions: This prospective cohort study shows the high burden of caring for HNC patients, the impact of this burden and the interaction between caregiver and patient. We suggest that healthcare professionals include caregivers in counseling and support.

Published
2022

153. Study retention and attrition in a longitudinal cohort study including patient-reported outcomes, fieldwork and biobank samples:results of the Netherlands quality of life and Biomedical cohort study (NET-QUBIC) among 739 head and neck cancer patients and 262 informal caregivers

Author

Jansen, Femke, Brakenhoff, Ruud H., Baatenburg de Jong, Rob J., Langendijk, Johannes A., Leemans, C. René, Takes, Robert P., Terhaard, Chris H.J., Smit, Jan H., Verdonck-de Leeuw, Irma M., Jansen, Femke, Brakenhoff, Ruud H., Baatenburg de Jong, Rob J., Langendijk, Johannes A., Leemans, C. René, Takes, Robert P., Terhaard, Chris H.J., Smit, Jan H., and Verdonck-de Leeuw, Irma M.

Abstract

Background: Longitudinal observational cohort studies in cancer patients are important to move research and clinical practice forward. Continued study participation (study retention) is of importance to maintain the statistical power of research and facilitate representativeness of study findings. This study aimed to investigate study retention and attrition (drop-out) and its associated sociodemographic and clinical factors among head and neck cancer (HNC) patients and informal caregivers included in the Netherlands Quality of Life and Biomedical Cohort Study (NET-QUBIC). Methods: NET-QUBIC is a longitudinal cohort study among 739 HNC patients and 262 informal caregivers with collection of patient-reported outcome measures (PROMs), fieldwork data (interview, objective tests and medical examination) and biobank materials. Study retention and attrition was described from baseline (before treatment) up to 2-years follow-up (after treatment). Sociodemographic and clinical characteristics associated with retention in NET-QUBIC components at baseline (PROMs, fieldwork and biobank samples) and retention in general (participation in at least one component) were investigated using Chi-square, Fisher exact or independent t-tests (p< 0.05). Results: Study retention at 2-years follow-up was 80% among patients alive (66% among all patients) and 70% among caregivers of patients who were alive and participating (52% among all caregivers). Attrition was most often caused by mortality, and logistic, physical, or psychological-related reasons. Tumor stage I/II, better physical performance and better (lower) comorbidity score were associated with participation in the PROMs component among patients. No factors associated with participation in the fieldwork component (patients), overall sample collection (patients and caregivers) or PROMs component (caregivers) were identified. A better performance and comorbidity score (among patients) and higher age (among caregivers) were asso

Published
2022

154. Caregiver Burden, Psychological Distress and Quality of Life among Informal Caregivers of Patients with Head and Neck Cancer: A Longitudinal Study

Author

MS Radiotherapie, Van Hof, Kira S, Hoesseini, Arta, Dorr, Maarten C, Verdonck-de Leeuw, Irma M, Jansen, Femke, Leemans, C René, Takes, Robert P, Terhaard, Chris H J, Baatenburg de Jong, Robert Jan, Sewnaik, Aniel, Offerman, Marinella P J, MS Radiotherapie, Van Hof, Kira S, Hoesseini, Arta, Dorr, Maarten C, Verdonck-de Leeuw, Irma M, Jansen, Femke, Leemans, C René, Takes, Robert P, Terhaard, Chris H J, Baatenburg de Jong, Robert Jan, Sewnaik, Aniel, and Offerman, Marinella P J

Published
2022

155. Prospective longitudinal study on fear of cancer recurrence in patients newly diagnosed with head and neck cancer: Course, trajectories, and associated factors

Author

MS Radiotherapie, Deuning-Smit, Esther, Custers, José A.E., Miroševič, Špela, Takes, Robert P., Jansen, Femke, Langendijk, Johannes A., Terhaard, Chris H.J., Baatenburg de Jong, Robert J., Leemans, C. René, Smit, Johannes H., Kwakkenbos, Linda, Verdonck-de Leeuw, Irma M., Prins, Judith B., MS Radiotherapie, Deuning-Smit, Esther, Custers, José A.E., Miroševič, Špela, Takes, Robert P., Jansen, Femke, Langendijk, Johannes A., Terhaard, Chris H.J., Baatenburg de Jong, Robert J., Leemans, C. René, Smit, Johannes H., Kwakkenbos, Linda, Verdonck-de Leeuw, Irma M., and Prins, Judith B.

Published
2022

156. Study retention and attrition in a longitudinal cohort study including patient-reported outcomes, fieldwork and biobank samples: results of the Netherlands quality of life and Biomedical cohort study (NET-QUBIC) among 739 head and neck cancer patients and 262 informal caregivers

Author

Divisie Beeld & Oncologie, MS Radiotherapie, Jansen, Femke, Brakenhoff, Ruud H., Baatenburg de Jong, Rob J., Langendijk, Johannes A., Leemans, C. René, Takes, Robert P., Terhaard, Chris H.J., Smit, Jan H., Verdonck-de Leeuw, Irma M., Divisie Beeld & Oncologie, MS Radiotherapie, Jansen, Femke, Brakenhoff, Ruud H., Baatenburg de Jong, Rob J., Langendijk, Johannes A., Leemans, C. René, Takes, Robert P., Terhaard, Chris H.J., Smit, Jan H., and Verdonck-de Leeuw, Irma M.

Published
2022

157. Psychoneurological Symptoms and Biomarkers of Stress and Inflammation in Newly Diagnosed Head and Neck Cancer Patients: A Network Analysis

Author

MS Radiotherapie, Santoso, Angelina M M, Jansen, Femke, Peeters, Carel F W, Baatenburg de Jong, Robert J, Brakenhoff, Ruud H, Langendijk, Johannes A, Leemans, C René, Takes, Robert P, Terhaard, Chris H J, van Straten, Annemieke, Verdonck-de Leeuw, Irma M, MS Radiotherapie, Santoso, Angelina M M, Jansen, Femke, Peeters, Carel F W, Baatenburg de Jong, Robert J, Brakenhoff, Ruud H, Langendijk, Johannes A, Leemans, C René, Takes, Robert P, Terhaard, Chris H J, van Straten, Annemieke, and Verdonck-de Leeuw, Irma M

Published
2022

158. Correction to: The course of swallowing problems in the first 2 years after diagnosis of head and neck cancer (Supportive Care in Cancer, (2022), 30, 11, (9527-9538), 10.1007/s00520-022-07322-w)

Author

Cancer, Onderzoek Radiotherapie, Klinische Fysica RT, Epidemiology & Health Economics, Epi Kanker Team C, JC onderzoeksprogramma Kanker, MS Radiotherapie, MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Vermaire, Jorine A., Raaijmakers, Cornelis P.J., Monninkhof, Evelyn M., Leemans, C. René, de Jong, Robert J.Baatenburg, Takes, Robert P., Verdonck-de Leeuw, Irma M., Jansen, Femke, Langendijk, Johannes A., Terhaard, Chris H.J., Speksnijder, Caroline M., Cancer, Onderzoek Radiotherapie, Klinische Fysica RT, Epidemiology & Health Economics, Epi Kanker Team C, JC onderzoeksprogramma Kanker, MS Radiotherapie, MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Vermaire, Jorine A., Raaijmakers, Cornelis P.J., Monninkhof, Evelyn M., Leemans, C. René, de Jong, Robert J.Baatenburg, Takes, Robert P., Verdonck-de Leeuw, Irma M., Jansen, Femke, Langendijk, Johannes A., Terhaard, Chris H.J., and Speksnijder, Caroline M.

Published
2022

159. Psychological Problems among Head and Neck Cancer Patients in Relation to Utilization of Healthcare and Informal Care and Costs in the First Two Years after Diagnosis

Author

MS Radiotherapie, van Beek, Florie E, Jansen, Femke, Baatenburg de Jong, Rob J, Langendijk, Johannes A, Leemans, C René, Smit, Johannes H, Takes, Robert P, Terhaard, Chris H J, Custers, José A E, Prins, Judith B, Lissenberg-Witte, Birgit I, Verdonck-de Leeuw, Irma M, MS Radiotherapie, van Beek, Florie E, Jansen, Femke, Baatenburg de Jong, Rob J, Langendijk, Johannes A, Leemans, C René, Smit, Johannes H, Takes, Robert P, Terhaard, Chris H J, Custers, José A E, Prins, Judith B, Lissenberg-Witte, Birgit I, and Verdonck-de Leeuw, Irma M

Published
2022

160. The course of swallowing problems in the first 2 years after diagnosis of head and neck cancer

Author

Cancer, Onderzoek Radiotherapie, Klinische Fysica RT, Epidemiology & Health Economics, Epi Kanker Team C, JC onderzoeksprogramma Kanker, MS Radiotherapie, MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Vermaire, Jorine A., Raaijmakers, Cornelis P.J., Monninkhof, Evelyn M., Leemans, C. René, de Jong, Robert J.Baatenburg, Takes, Robert P., Leeuw, Irma M.Verdonck de, Jansen, Femke, Langendijk, Johannes A., Terhaard, Chris H.J., Speksnijder, Caroline M., Cancer, Onderzoek Radiotherapie, Klinische Fysica RT, Epidemiology & Health Economics, Epi Kanker Team C, JC onderzoeksprogramma Kanker, MS Radiotherapie, MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Vermaire, Jorine A., Raaijmakers, Cornelis P.J., Monninkhof, Evelyn M., Leemans, C. René, de Jong, Robert J.Baatenburg, Takes, Robert P., Leeuw, Irma M.Verdonck de, Jansen, Femke, Langendijk, Johannes A., Terhaard, Chris H.J., and Speksnijder, Caroline M.

Published
2022

161. Assessing the prognostic value of tumor-infiltrating CD57+ cells in advanced stage head and neck cancer using QuPath digital image analysis

Author

Pathologie Opleiding, Cancer, MS Hoofd-Hals Chirurgische Oncologie, MS Radiotherapie, Pathologie Pathologen staf, de Ruiter, Emma J, Bisheshar, Sangeeta K, de Roest, Reinout H, Wesseling, Frederik W R, Hoebers, Frank J P, van den Hout, Mari F C M, Leemans, C René, Brakenhoff, Ruud H, de Bree, Remco, Terhaard, Chris H J, Willems, Stefan M, Pathologie Opleiding, Cancer, MS Hoofd-Hals Chirurgische Oncologie, MS Radiotherapie, Pathologie Pathologen staf, de Ruiter, Emma J, Bisheshar, Sangeeta K, de Roest, Reinout H, Wesseling, Frederik W R, Hoebers, Frank J P, van den Hout, Mari F C M, Leemans, C René, Brakenhoff, Ruud H, de Bree, Remco, Terhaard, Chris H J, and Willems, Stefan M

Published
2022

162. Disease outcome and associated factors after definitive platinum based chemoradiotherapy for advanced stage HPV-negative head and neck cancer

Author

Pathologie patiënten zorg, Pathologie Opleiding, Cancer, MS Radiotherapie, MS Medische Oncologie, de Roest, Reinout H., van der Heijden, Martijn, Wesseling, Frederik W.R., de Ruiter, Emma J., Heymans, Martijn W., Terhaard, Chris, Vergeer, Marije R., Buter, Jan, Devriese, Lot A., de Boer, Jan Paul, Navran, Arash, Hoeben, Ann, Vens, Conchita, van den Brekel, Michiel, Brakenhoff, Ruud H., Leemans, C. René, Hoebers, Frank, Pathologie patiënten zorg, Pathologie Opleiding, Cancer, MS Radiotherapie, MS Medische Oncologie, de Roest, Reinout H., van der Heijden, Martijn, Wesseling, Frederik W.R., de Ruiter, Emma J., Heymans, Martijn W., Terhaard, Chris, Vergeer, Marije R., Buter, Jan, Devriese, Lot A., de Boer, Jan Paul, Navran, Arash, Hoeben, Ann, Vens, Conchita, van den Brekel, Michiel, Brakenhoff, Ruud H., Leemans, C. René, and Hoebers, Frank

Published
2022

163. Early Response Prediction of Multiparametric Functional MRI and F-18-FDG-PET in Patients with Head and Neck Squamous Cell Carcinoma Treated with (Chemo)Radiation

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Martens, Roland M, Koopman, Thomas, Lavini, Cristina, Brug, Tim van de, Zwezerijnen, Gerben J C, Marcus, J Tim, Vergeer, Marije R, Leemans, C René, Bree, Remco de, Graaf, Pim de, Boellaard, Ronald, Castelijns, Jonas A, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Martens, Roland M, Koopman, Thomas, Lavini, Cristina, Brug, Tim van de, Zwezerijnen, Gerben J C, Marcus, J Tim, Vergeer, Marije R, Leemans, C René, Bree, Remco de, Graaf, Pim de, Boellaard, Ronald, and Castelijns, Jonas A

Published
2022

167. Psychological Problems among Head and Neck Cancer Patients in Relation to Utilization of Healthcare and Informal Care and Costs in the First Two Years after Diagnosis

Author

van Beek, Florie E., primary, Jansen, Femke, additional, Baatenburg de Jong, Rob J., additional, Langendijk, Johannes A., additional, Leemans, C. René, additional, Smit, Johannes H., additional, Takes, Robert P., additional, Terhaard, Chris H. J., additional, Custers, José A. E., additional, Prins, Judith B., additional, Lissenberg-Witte, Birgit I., additional, and Verdonck-de Leeuw, Irma M., additional

Published
2022
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172. Prospective longitudinal study on fear of cancer recurrence in patients newly diagnosed with head and neck cancer: Course, trajectories, and associated factors

Author

Deuning‐Smit, Esther, primary, Custers, José A. E., additional, Miroševič, Špela, additional, Takes, Robert P., additional, Jansen, Femke, additional, Langendijk, Johannes A., additional, Terhaard, Chris H. J., additional, Baatenburg de Jong, Robert J., additional, Leemans, C. René, additional, Smit, Johannes H., additional, Kwakkenbos, Linda, additional, Verdonck‐de Leeuw, Irma M., additional, and Prins, Judith B., additional

Published
2022
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173. Early Response Prediction of Multiparametric Functional MRI and 18F-FDG-PET in Patients with Head and Neck Squamous Cell Carcinoma Treated with (Chemo)Radiation

Author

Martens, Roland M., primary, Koopman, Thomas, additional, Lavini, Cristina, additional, Brug, Tim van de, additional, Zwezerijnen, Gerben J. C., additional, Marcus, J. Tim, additional, Vergeer, Marije R., additional, Leemans, C. René, additional, Bree, Remco de, additional, Graaf, Pim de, additional, Boellaard, Ronald, additional, and Castelijns, Jonas A., additional

Published
2022
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181. Preface

Author

Vermorken, Jan B., Budach, Volker, Leemans, C. René, Machiels, Jean-Pascal, Nicolai, Piero, and O'Sullivan, Brian

Published
2021

182. NK Cell-Dependent Antibody-Mediated Immunotherapy Is Improved In Vitro and In Vivo When Combined with Agonists for Toll-like Receptor 2 in Head and Neck Cancer Models

Author

Gruijs, Mandy, primary, Ganzevles, Sonja H., additional, Stigter-van Walsum, Marijke, additional, van der Mast, Richard, additional, van Ostaijen-ten Dam, Monique M., additional, Tuk, Cornelis W., additional, Schilham, Marco W., additional, Leemans, C. René, additional, Brakenhoff, Ruud H., additional, van Egmond, Marjolein, additional, van de Ven, Rieneke, additional, and Bakema, Jantine E., additional

Published
2021
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184. Symptom monitoring in cancer and fully automated advice on supportive care: Patients' perspectives on self‐management strategies and the eHealth self‐management application Oncokompas

Author

Schuit, Anouk S., primary, Zwieten, Valesca, additional, Holtmaat, Karen, additional, Cuijpers, Pim, additional, Eerenstein, Simone E. J., additional, Leemans, C. René, additional, Vergeer, Marije R., additional, Voortman, Jens, additional, Karagozoglu, Hakki, additional, Weert, Stijn, additional, Korte, Mira, additional, Frambach, Ruud, additional, Fleuren, Margot, additional, Hendrickx, Jan‐Jaap, additional, and Verdonck‐de Leeuw, Irma M., additional

Published
2021
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187. Critical Issues in Head and Neck Oncology

Author

Vermorken, Jan B., Budach, Volker, Leemans, C. René, Machiels, Jean-Pascal, Nicolai, Piero, and O’Sullivan, Brian

Subjects
Oncology, Radiotherapy, Surgical Oncology, Internal Medicine, Radiology, Surgery, Nasopharynx cancer, Head and Neck Squamous Cell Cancer, non-oropharyngeal head and neck cancer, predictive biomarkers, liquid biopsies, induction chemotherapy, immunotherapy, precision medicine, HNSCC, Open Access, bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology, bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology::MJCL1 Radiotherapy, bic Book Industry Communication::M Medicine::MN Surgery::MNK Surgical oncology
Abstract

This open access book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck cancers. Readers will learn about the latest drug developments and epidemiological aspects in cancers ranging from Head and Neck Squamous Cell Cancer to Nasopharynx cancer. Edited by a team of world leaders in Head and Neck Cancer, this volume serves as an easy reference to the head and neck oncology practitioner and provides a contemporary overview for specialists the field. The chapters are based on the latest data presented at the 7th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field.

Published
2021
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195. A Prospectively Validated Prognostic Model for Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck Based on Radiomics of Computed Tomography Images

Author

Keek, Simon A., primary, Wesseling, Frederik W. R., additional, Woodruff, Henry C., additional, van Timmeren, Janita E., additional, Nauta, Irene H., additional, Hoffmann, Thomas K., additional, Cavalieri, Stefano, additional, Calareso, Giuseppina, additional, Primakov, Sergey, additional, Leijenaar, Ralph T. H., additional, Licitra, Lisa, additional, Ravanelli, Marco, additional, Scheckenbach, Kathrin, additional, Poli, Tito, additional, Lanfranco, Davide, additional, Vergeer, Marije R., additional, Leemans, C. René, additional, Brakenhoff, Ruud H., additional, Hoebers, Frank J. P., additional, and Lambin, Philippe, additional

Published
2021
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197. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Author

Jansen, Femke, primary, Coupé, Veerle M.H., additional, Eerenstein, Simone E.J., additional, Cnossen, Ingrid C., additional, van Uden-Kraan, Cornelia F., additional, de Bree, Remco, additional, Doornaert, Patricia, additional, Halmos, György B., additional, Hardillo, José A.U., additional, van Hinte, Gerben, additional, Honings, Jimmie, additional, Leemans, C. René, additional, and Verdonck-de Leeuw, Irma M., additional

Published
2021
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199. Safety and Feasibility of Surgery for Oropharyngeal Cancers During the SARS-CoV-2-Pandemic.

Author

UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, Gorphe, Philippe, Grandbastien, Bruno, Dietz, Andreas, Duvvuri, Umamaheswar, Ferris, Robert L, Golusinski, Wojciech, Holsinger, Floyd Christopher, Hosal, Sefik, Lawson, Georges, Mehanna, Hisham, Paleri, Vinidh, Shaw, Richard, Succo, Giovanni, Leemans, C René, Simon, Christian, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, Gorphe, Philippe, Grandbastien, Bruno, Dietz, Andreas, Duvvuri, Umamaheswar, Ferris, Robert L, Golusinski, Wojciech, Holsinger, Floyd Christopher, Hosal, Sefik, Lawson, Georges, Mehanna, Hisham, Paleri, Vinidh, Shaw, Richard, Succo, Giovanni, Leemans, C René, and Simon, Christian

Published
2021

200. European white paper:oropharyngeal dysphagia in head and neck cancer

Author

Baijens, Laura W.J., Walshe, Margaret, Aaltonen, Leena Maija, Arens, Christoph, Cordier, Reinie, Cras, Patrick, Crevier-Buchman, Lise, Curtis, Chris, Golusinski, Wojciech, Govender, Roganie, Eriksen, Jesper Grau, Hansen, Kevin, Heathcote, Kate, Hess, Markus M., Hosal, Sefik, Klussmann, Jens Peter, Leemans, C. René, MacCarthy, Denise, Manduchi, Beatrice, Marie, Jean Paul, Nouraei, Reza, Parkes, Claire, Pflug, Christina, Pilz, Walmari, Regan, Julie, Rommel, Nathalie, Schindler, Antonio, Schols, Annemie M.W.J., Speyer, Renee, Succo, Giovanni, Wessel, Irene, Willemsen, Anna C.H., Yilmaz, Taner, Clavé, Pere, Baijens, Laura W.J., Walshe, Margaret, Aaltonen, Leena Maija, Arens, Christoph, Cordier, Reinie, Cras, Patrick, Crevier-Buchman, Lise, Curtis, Chris, Golusinski, Wojciech, Govender, Roganie, Eriksen, Jesper Grau, Hansen, Kevin, Heathcote, Kate, Hess, Markus M., Hosal, Sefik, Klussmann, Jens Peter, Leemans, C. René, MacCarthy, Denise, Manduchi, Beatrice, Marie, Jean Paul, Nouraei, Reza, Parkes, Claire, Pflug, Christina, Pilz, Walmari, Regan, Julie, Rommel, Nathalie, Schindler, Antonio, Schols, Annemie M.W.J., Speyer, Renee, Succo, Giovanni, Wessel, Irene, Willemsen, Anna C.H., Yilmaz, Taner, and Clavé, Pere

Abstract

Purpose: To develop a European White Paper document on oropharyngeal dysphagia (OD) in head and neck cancer (HNC). There are wide variations in the management of OD associated with HNC across Europe. Methods: Experts in the management of specific aspects of OD in HNC across Europe were delegated by their professional medical and multidisciplinary societies to contribute to this document. Evidence is based on systematic reviews, consensus-based position statements, and expert opinion. Results: Twenty-four sections on HNC-specific OD topics. Conclusion: This European White Paper summarizes current best practice on management of OD in HNC, providing recommendations to support patients and health professionals. The body of literature and its level of evidence on diagnostics and treatment for OD in HNC remain poor. This is in the context of an expected increase in the prevalence of OD due to HNC in the near future. Contributing factors to increased prevalence include aging of our European population (including HNC patients) and an increase in human papillomavirus (HPV) related cancer, despite the introduction of HPV vaccination in various countries. We recommend timely implementation of OD screening in HNC patients while emphasizing the need for robust scientific research on the treatment of OD in HNC. Meanwhile, its management remains a challenge for European professional associations and policymakers.

Published
2021

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