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152. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Author

Infection & Immunity, Afdeling Longfunctie, Longziekten, Hobbs, Brian D, de Jong, Kim, Lamontagne, Maxime, Bossé, Yohan, Shrine, Nick, Artigas, María Soler, Wain, Louise V, Hall, Ian P, Jackson, Victoria E, Wyss, Annah B, London, Stephanie J, North, Kari E, Franceschini, Nora, Strachan, David P, Beaty, Terri H, Hokanson, John E, Crapo, James D, Castaldi, Peter J, Chase, Robert P, Bartz, Traci M, Heckbert, Susan R, Psaty, Bruce M, Gharib, Sina A, Zanen, Pieter, Lammers, Jan W, Oudkerk, Matthijs, Groen, H J, Locantore, Nicholas, Tal-Singer, Ruth, Rennard, Stephen I, Vestbo, Jørgen, Timens, Wim, Paré, Peter D, Latourelle, Jeanne C, Dupuis, Josée, O'Connor, George T, Wilk, Jemma B, Kim, Woo Jin, Lee, Mi Kyeong, Oh, Yeon-Mok, Vonk, Judith M, de Koning, Harry J, Leng, Shuguang, Belinsky, Steven A, Tesfaigzi, Yohannes, Manichaikul, Ani, Wang, Xin-Qun, Rich, Stephen S, Barr, R Graham, Sparrow, David, COPDGene Investigators, Infection & Immunity, Afdeling Longfunctie, Longziekten, Hobbs, Brian D, de Jong, Kim, Lamontagne, Maxime, Bossé, Yohan, Shrine, Nick, Artigas, María Soler, Wain, Louise V, Hall, Ian P, Jackson, Victoria E, Wyss, Annah B, London, Stephanie J, North, Kari E, Franceschini, Nora, Strachan, David P, Beaty, Terri H, Hokanson, John E, Crapo, James D, Castaldi, Peter J, Chase, Robert P, Bartz, Traci M, Heckbert, Susan R, Psaty, Bruce M, Gharib, Sina A, Zanen, Pieter, Lammers, Jan W, Oudkerk, Matthijs, Groen, H J, Locantore, Nicholas, Tal-Singer, Ruth, Rennard, Stephen I, Vestbo, Jørgen, Timens, Wim, Paré, Peter D, Latourelle, Jeanne C, Dupuis, Josée, O'Connor, George T, Wilk, Jemma B, Kim, Woo Jin, Lee, Mi Kyeong, Oh, Yeon-Mok, Vonk, Judith M, de Koning, Harry J, Leng, Shuguang, Belinsky, Steven A, Tesfaigzi, Yohannes, Manichaikul, Ani, Wang, Xin-Qun, Rich, Stephen S, Barr, R Graham, Sparrow, David, and COPDGene Investigators

Published
2017

155. Diterpenoids and Diacetylenes from the Roots of Aralia cordatawith Inhibitory Effects on Nitric Oxide Production

Author

Kim, Jun Gu, Lee, Jin Woo, Le, Thi Phuong Linh, Han, Jae Sang, Kwon, Haeun, Lee, Dongho, Hong, Jin Tae, Kim, Youngsoo, Lee, Mi Kyeong, and Hwang, Bang Yeon

Abstract

Bioactivity-guided isolation of a MeOH extract of Aralia cordataled to the isolation of four new ent-pimarane diterpenoids (1–4) and a diacetylene (5) together with 21 known compounds (6–26). Their structures were established based on the interpretation of one- and two-dimensional NMR and HRESIMS data. The absolute configurations of the new isolates were determined by electronic circular dichroism data analysis, single crystal X-ray diffraction, and Mosher’s esterification method. All compounds exhibited inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50values ranging from 1.1 to 69.4 μM.

Published
2021
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157. Multiethnic meta-analysis identifies new loci for pulmonary function

Author

Wyss, Annah B., primary, Sofer, Tamar, additional, Lee, Mi Kyeong, additional, Terzikhan, Natalie, additional, Nguyen, Jennifer N., additional, Lahousse, Lies, additional, Latourelle, Jeanne C., additional, Smith, Albert Vernon, additional, Bartz, Traci M., additional, Feitosa, Mary F., additional, Gao, Wei, additional, Ahluwalia, Tarunveer S., additional, Tang, Wenbo, additional, Oldmeadow, Christopher, additional, Duan, Qing, additional, Jong, Kim de, additional, Wojczynski, Mary K., additional, Wang, Xin-Qun, additional, Noordam, Raymond, additional, Hartwig, Fernando Pires, additional, Jackson, Victoria E., additional, Wang, Tianyuan, additional, Obeidat, Ma’en, additional, Hobbs, Brian D., additional, Huan, Tianxiao, additional, Kichaev, Gleb, additional, Jin, Jianping, additional, Graff, Mariaelisa, additional, Harris, Tamara B., additional, Kalhan, Ravi, additional, Heckbert, Susan R., additional, Paternoster, Lavinia, additional, Burkart, Kristin M., additional, Liu, Yongmei, additional, Holliday, Elizabeth G., additional, Wilson, James G., additional, Vonk, Judith M., additional, Sanders, Jason, additional, Barr, R. Graham, additional, Mutsert, Renée de, additional, Menezes, Ana Maria Baptista, additional, Adams, Hieab H. H., additional, Berge, Maarten van den, additional, Joehanes, Roby, additional, Launer, Lenore J., additional, Morrison, Alanna C., additional, Sitlani, Colleen M., additional, Celedón, Juan C., additional, Kritchevsky, Stephen B., additional, Scott, Rodney J., additional, Christensen, Kaare, additional, Rotter, Jerome I., additional, Bonten, Tobias N., additional, César Wehrmeister, Fernando, additional, Bossé, Yohan, additional, Franceschini, Nora, additional, Brody, Jennifer A., additional, Kaplan, Robert C., additional, Lohman, Kurt, additional, McEvoy, Mark, additional, Province, Michael A., additional, Rosendaal, Frits R., additional, Taylor, Kent D., additional, Nickle, David C., additional, North, Kari E., additional, Fornage, Myriam, additional, Psaty, Bruce M., additional, Myers, Richard H., additional, O’Connor, George, additional, Hansen, Torben, additional, Laurie, Cathy C., additional, Cassano, Pat, additional, Sung, Joohon, additional, Kim, Woo Jin, additional, Attia, John R., additional, Lange, Leslie, additional, Boezen, H. Marike, additional, Thyagarajan, Bharat, additional, Rich, Stephen S., additional, Mook-Kanamori, Dennis O., additional, Horta, Bernardo Lessa, additional, Uitterlinden, André G, additional, Sin, Don D., additional, Im, Hae Kyung, additional, Cho, Michael H., additional, Brusselle, Guy G., additional, Gharib, Sina A., additional, Dupuis, Josée, additional, Manichaikul, Ani, additional, and London, Stephanie J., additional

Published
2017
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165. Phenylpropanoid-Conjugated Triterpenoids from the Leaves of Actinidia argutaand Their Inhibitory Activity on α-Glucosidase

Author

Ahn, Jong Hoon, Park, Youngki, Yeon, Sang Won, Jo, Yang Hee, Han, Yoo Kyong, Turk, Ayman, Ryu, Se Hwan, Hwang, Bang Yeon, Lee, Ki Yong, and Lee, Mi Kyeong

Abstract

Actinidia arguta, commonly called hardy kiwifruit or kiwiberry, has cold-resistant properties and can be cultivated in Asia, including Korea. Seven new triterpenoids (2–4and 8–11) along with eight known triterpenoids were isolated from the leaves of A. argutathrough various chromatographic techniques. The new triterpenoids were defined as actiniargupenes A–C (2–4), actinidic acid derivatives with phenylpropanoid constituent units, dehydroisoactinidic acid (8), and actiniargupenes D–F (9–11), asiatic acid derivatives with phenylpropanoid substituents, on the basis of 1D and 2D NMR and MS data. Among the triterpenoids, those with a phenylpropanoid constituent unit showed inhibitory activity on α-glucosidase, which suggested the importance of the phenylpropanoid moiety. Molecular docking analysis demonstrated the interaction between the 4′-OH group of the phenylpropanoid moiety and α-glucosidase.

Published
2020
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169. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author

Loth, Daan W., Gharib, Sina A., Wain, Louise V., Franceschini, Nora, Koch, Beate, Pottinger, Tess D., Smith, Albert Vernon, Duan, Qing, Oldmeadow, Chris, Lee, Mi Kyeong, Strachan, David P., James, Alan L., Huffman, Jennifer E., Vitart, Veronique, Ramasamy, Adaikalavan, Wareham, Nicholas J., Kaprio, Jaakko, Wang, Xin-Qun, Trochet, Holly, Flexeder, Claudia, Albrecht, Eva, Lopez, Lorna M., de Jong, Kim, Thyagarajan, Bharat, Alves, Alexessander Couto, Enroth, Stefan, Omenaas, Ernst, Joshi, Peter K., Fall, Tove, Launer, Lenore J., Loehr, Laura R., Fornage, Myriam, Li, Guo, Wilk, Jemma B., Tang, Wenbo, Manichaikul, Ani, Lahousse, Lies, Harris, Tamara B., North, Kari E., Rudnicka, Alicja R., Hui, Jennie, Gu, Xiangjun, Lumley, Thomas, Wright, Alan F., Hastie, Nicholas D., Campbell, Susan, Kumar, Rajesh, Pin, Isabelle, Scott, Robert A., Surakka, Ida, Liu, Yongmei, Holliday, Elizabeth G., Schulz, Holger, Heinrich, Joachim, Davies, Gail, Vonk, Judith M., Wojczynski, Mary, Pouta, Anneli, Wild, Sarah H., Ingelsson, Erik, Rivadeneira, Fernando, Hysi, Pirro G., Eiriksdottir, Gudny, Morrison, Alanna C., Rotter, Jerome I., Gao, Wei, Postma, Dirkje S., White, Wendy B., Rich, Stephen S., Hofman, Albert, Aspelund, Thor, Couper, David, Smith, Lewis J., Psaty, Bruce M., Lohman, Kurt, Burchard, Esteban G., Garcia, Melissa, Joubert, Bonnie R., McArdle, Wendy L., Musk, A Bill, Hansel, Nadia, Heckbert, Susan R., Zgaga, Lina, van Meurs, Joyce B.J., Navarro, Pau, Rudan, Igor, Oh, Yeon-Mok, Redline, Susan, Jarvis, Deborah L., Zhao, Jing Hua, Rantanen, Taina, O'Connor, George T., Ripatti, Samuli, Scott, Rodney J., Karrasch, Stefan, Grallert, Harald, Gaddis, Nathan C., Starr, John M., Wijmenga, Cisca, Minster, Ryan L., Lederer, David J., Pekkanen, Juha, Gyllensten, Ulf, Campbell, Harry, Morris, Andrew P., Hammond, Christopher J., Burkart, Kristin M, Beilby, John, Kritchevsky, Stephen B., Gudnason, Vilmundur, Hancock, Dana B., Williams, O Dale, Polasek, Ozren, Zemunik, Tatijana, Kolcic, Ivana, Petrini, Marcy F., Wjst, Matthias, Kim, Woo Jin, Porteous, David J., Smith, Blair H., Viljanen, Anne, Attia, John R., Sayers, Ian, Hampel, Regina, Gieger, Christian, Deary, Ian J, Boezen, H. Marike, Newman, Anne, Jarvelin, Marjo-Riitta, Wilson, James F, Lind, Lars, Stricker, Bruno H., Teumer, Alexander, Spector, Timothy D., Peters, Marjolein J., Lange, Leslie A., Barr, R. Graham, Bracke, Ken R., Verhamme, Fien M., Sung, Joohon, Hiemstra, Pieter S., Cassano, Patricia A., Sood, Akshay, Hayward, Caroline, Hall, Ian P., Brusselle, Guy G., Tobin, Martin D., and London, Stephanie J.

Subjects
respiratory system, Genetics research, Genome-wide association studies, Population genetics, Respiratory tract diseases, respiratory tract diseases
Abstract

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10-8) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.© 2014 Nature America, Inc. All rights reserved.

Published
2014

182. Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology

Author

Lee, Jin Woo, primary, Mo, Eun Jin, additional, Choi, Ji Eun, additional, Jo, Yang Hee, additional, Jang, Hari, additional, Jeong, Ji Yeon, additional, Jin, Qinghao, additional, Chung, Hee Nam, additional, Hwang, Bang Yeon, additional, and Lee, Mi Kyeong, additional

Published
2016
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186. Comparison of Metabolites Variation and Antiobesity Effects of Fermented versus Nonfermented Mixtures of Cudrania tricuspidata, Lonicera caerulea, and Soybean According to Fermentation In Vitro and In Vivo

Author

Suh, Dong Ho, primary, Jung, Eun Sung, additional, Park, Hye Min, additional, Kim, Seung Hyung, additional, Lee, Sarah, additional, Jo, Yang Hee, additional, Lee, Mi Kyeong, additional, Jung, Gayoung, additional, Do, Seon-Gil, additional, and Lee, Choong Hwan, additional

Published
2016
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192. Phenolic amides from <italic>Tribulus terrestris</italic> and their inhibitory effects on nitric oxide production in RAW 264.7 cells.

Author

Kim, Hyung Sik, Lee, Jin Woo, Jang, Hari, Le, Thi Phuong Linh, Kim, Jun Gu, Lee, Moon Soon, Hong, Jin Tae, Lee, Mi Kyeong, and Hwang, Bang Yeon

Abstract

A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1–6, 8–11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC50 values of 18.7–49.4 μM. [ABSTRACT FROM AUTHOR]

Published
2018
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193. Sesquiterpenes from fruits of Torilis japonica with inhibitory activity on melanin synthesis in B16 cells.

Author

Song, Da Hye, Jo, Yang Hee, Ahn, Jong Hoon, Kim, Seon Beom, Yun, Cheong-Yong, Kim, Youngsoo, Hwang, Bang Yeon, and Lee, Mi Kyeong

Abstract

Melanin, a dark macromolecular pigment, protects skin from harmful damage. However, abnormal accumulation is responsible for hyperpigmentation disorders. Melanogenesis inhibitors have therefore become important constituents in cosmetic products for depigmentation. Torilis japonica Decandolle (Umbelliferae) is a biennial plant which is distributed in East Asia. Fruits of this plant have been used for the treatment of skin disease and inflammation. In our previous study, torilin, a major sesquiterpene of T. japonica, showed an inhibitory effect on melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Further extensive chromatographic separation resulted in thirteen compounds. On the basis of spectroscopic analysis, the structures of the compounds isolated were determined to be three new sesquiterpenes, viz. a guaiane-type, epoxytorilinol ( 1), a eudesmane-type, elematorilone ( 2) and a cadinane-type, cardinatoriloside ( 3), together with ten known sesquiterpenes ( 4- 13). Of the compounds isolated, compounds 4-6 and 11-13 inhibited α-MSH-activated melanin production in B16 melanoma cells with IC values from 72.9 to 191.0 μM. [ABSTRACT FROM AUTHOR]

Published
2018
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194. Lignans from Saururus chinensiswith Inhibitory Effects on Nitric Oxide Production

Author

Jin, Qinghao, Lee, Jin Woo, Kim, Jun Gu, Lee, Dongho, Hong, Jin Tae, Kim, Youngsoo, Lee, Mi Kyeong, and Hwang, Bang Yeon

Abstract

Three biogenetically related ent-sauchinone-type lignans (1–3), four 8-O-4′-type neolignans (4–7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1–9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type lignans (1–3) was postulated. Compounds 1, 7, and 10showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50values of 5.6, 8.6, and 9.2 μM, respectively.

Published
2019
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195. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Author

Sakornsakolpat, Phuwanat, Prokopenko, Dmitry, Lamontagne, Maxime, Reeve, Nicola F., Guyatt, Anna L., Jackson, Victoria E., Shrine, Nick, Qiao, Dandi, Bartz, Traci M., Kim, Deog Kyeom, Lee, Mi Kyeong, Latourelle, Jeanne C., Li, Xingnan, Morrow, Jarrett D., Obeidat, Ma’en, Wyss, Annah B., Bakke, Per, Barr, R. Graham, Beaty, Terri H., Belinsky, Steven A., Brusselle, Guy G., Crapo, James D., de Jong, Kim, DeMeo, Dawn L., Fingerlin, Tasha E., Gharib, Sina A., Gulsvik, Amund, Hall, Ian P., Hokanson, John E., Kim, Woo Jin, Lomas, David A., London, Stephanie J., Meyers, Deborah A., O’Connor, George T., Rennard, Stephen I., Schwartz, David A., Sliwinski, Pawel, Sparrow, David, Strachan, David P., Tal-Singer, Ruth, Tesfaigzi, Yohannes, Vestbo, Jørgen, Vonk, Judith M., Yim, Jae-Joon, Zhou, Xiaobo, Bossé, Yohan, Manichaikul, Ani, Lahousse, Lies, Silverman, Edwin K., Boezen, H. Marike, Wain, Louise V., Tobin, Martin D., Hobbs, Brian D., and Cho, Michael H.

Abstract

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P< 5 × 10−8; 47 of these were previously described in association with either COPD or population-based measures of lung function. Of the remaining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified functional enrichment of COPD risk loci in lung tissue, smooth muscle, and several lung cell types. We found 14 COPD loci shared with either asthma or pulmonary fibrosis. COPD genetic risk loci clustered into groups based on associations with quantitative imaging features and comorbidities. Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD.

Published
2019
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