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152. Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording

Author

Chang Hyeon Ji, Lee Youjin, Sang Beom Jun, Yoon Kyung Cho, Daeho Ryu, Saeyeong Jeon, and Yena Lee

Subjects
Computer science, Channelrhodopsin, Optogenetics, Light delivery, Article, 03 medical and health sciences, channelrhodopsin, 0302 clinical medicine, optrode, TJ1-1570, Mechanical engineering and machinery, Electrical and Electronic Engineering, optogenetics, 030304 developmental biology, 0303 health sciences, business.industry, Mechanical Engineering, electrode, electrophysiology, Line (electrical engineering), Neuromodulation (medicine), Electrophysiology, Control and Systems Engineering, Modulation, Optoelectronics, Optode, business, 030217 neurology & neurosurgery
Abstract

During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.

Published
2021

153. Highly Efficient Nonvolatile Magnetization Switching and Multi‐Level States by Current in Single Van der Waals Topological Ferromagnet Fe3GeTe2.

Author

Zhang, Kaixuan, Lee, Youjin, Coak, Matthew J., Kim, Junghyun, Son, Suhan, Hwang, Inho, Ko, Dong‐Su, Oh, Youngtek, Jeon, Insu, Kim, Dohun, Zeng, Changgan, Lee, Hyun‐Woo, and Park, Je‐Geun

Subjects
*MAGNETIZATION, *RANDOM access memory, *SPINTRONICS, *POWER density, *ENERGY consumption, *MAGNETS
Abstract

Robust multi‐level spin memory with the ability to write information electrically is a long‐sought capability in spintronics, with great promise for applications. Here, nonvolatile and highly energy‐efficient magnetization switching is achieved in a single‐material device formed of van‐der‐Waals (vdW) topological ferromagnet Fe3GeTe2, whose magnetic information can be readily controlled by a tiny current. Furthermore, the switching current density and power dissipation are about 400 and 4000 times smaller than those of the existing spin‐orbit‐torque magnetic random access memory based on conventional magnet/heavy‐metal systems. Most importantly, multi‐level states, switched by electrical current are also demonstrated, which can dramatically enhance the information capacity density and reduce computing costs. Thus, the observations combine both high energy efficiency and large information capacity density in one device, showcasing the potential applications of the emerging field of vdW magnets in the field of spin memory and spintronics. [ABSTRACT FROM AUTHOR]

Published
2021
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154. Highly Efficient Nonvolatile Magnetization Switching and Multi‐Level States by Current in Single Van der Waals Topological Ferromagnet Fe3GeTe2.

Author

Zhang, Kaixuan, Lee, Youjin, Coak, Matthew J., Kim, Junghyun, Son, Suhan, Hwang, Inho, Ko, Dong‐Su, Oh, Youngtek, Jeon, Insu, Kim, Dohun, Zeng, Changgan, Lee, Hyun‐Woo, and Park, Je‐Geun

Subjects
MAGNETIZATION, RANDOM access memory, SPINTRONICS, POWER density, ENERGY consumption, MAGNETS
Abstract

Robust multi‐level spin memory with the ability to write information electrically is a long‐sought capability in spintronics, with great promise for applications. Here, nonvolatile and highly energy‐efficient magnetization switching is achieved in a single‐material device formed of van‐der‐Waals (vdW) topological ferromagnet Fe3GeTe2, whose magnetic information can be readily controlled by a tiny current. Furthermore, the switching current density and power dissipation are about 400 and 4000 times smaller than those of the existing spin‐orbit‐torque magnetic random access memory based on conventional magnet/heavy‐metal systems. Most importantly, multi‐level states, switched by electrical current are also demonstrated, which can dramatically enhance the information capacity density and reduce computing costs. Thus, the observations combine both high energy efficiency and large information capacity density in one device, showcasing the potential applications of the emerging field of vdW magnets in the field of spin memory and spintronics. [ABSTRACT FROM AUTHOR]

Published
2021
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156. Search for long-lived particles decaying into displaced jets in proton-proton collisions at √s = 13 TeV

Author

Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Abercrombie, Daniel Robert, Allen, Brandon Leigh, Azzolini, Virginia, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, Sruthi A., Niu, Xinmei, Paus, Christoph M. E., Terry, David Rankin, Roland, Christof E, Roland, Gunther M, Shi, Zhaozhong, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jianchun, Wang, Tianwen, Wyslouch, Boleslaw, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Abercrombie, Daniel Robert, Allen, Brandon Leigh, Azzolini, Virginia, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, Sruthi A., Niu, Xinmei, Paus, Christoph M. E., Terry, David Rankin, Roland, Christof E, Roland, Gunther M, Shi, Zhaozhong, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jianchun, Wang, Tianwen, and Wyslouch, Boleslaw

Abstract

A search for long-lived particles decaying into jets is presented. Data were collected with the CMS detector at the LHC from proton-proton collisions at a center-of-mass energy of 13 TeV in 2016, corresponding to an integrated luminosity of 35.9 fb⁻¹. The search examines the distinctive topology of displaced tracks and secondary vertices. The selected events are found to be consistent with standard model predictions. For a simplified model in which long-lived neutral particles are pair produced and decay to two jets, pair production cross sections larger than 0.2 fb are excluded at 95% confidence level for a long-lived particle mass larger than 1000 GeV and proper decay lengths between 3 and 130 mm. Several supersymmetry models with gauge-mediated supersymmetry breaking or R-parity violation, where pair-produced long-lived gluinos or top squarks decay to several final-state topologies containing displaced jets, are also tested. For these models, in the mass ranges above 200 GeV, gluino masses up to 2300–2400 GeV and top squark masses up to 1350–1600 GeV are excluded for proper decay lengths approximately between 10 and 100 mm. These are the most restrictive limits to date on these models.

Published
2019

157. Search for dark matter produced in association with a single top quark or a top quark pair in proton-proton collisions at √s =13 TeV

Author

Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Abercrombie, Daniel Robert, Allen, Brandon Leigh, Azzolini, Virginia, Baty, Austin Alan, Bauer, Gerry P, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, S., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Shi, Zhaozhong, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, Wyslouch, Boleslaw, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Abercrombie, Daniel Robert, Allen, Brandon Leigh, Azzolini, Virginia, Baty, Austin Alan, Bauer, Gerry P, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, S., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Shi, Zhaozhong, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, and Wyslouch, Boleslaw

Abstract

A search for dark matter produced in association with top quarks in proton-proton collisions at a center-of-mass energy of 13 TeV is presented. The data set used corresponds to an integrated luminosity of 35.9 fb⁻¹ recorded with the CMS detector at the LHC. Whereas previous searches for neutral scalar or pseudoscalar mediators considered dark matter production in association with a top quark pair only, this analysis also includes production modes with a single top quark. The results are derived from the combination of multiple selection categories that are defined to target either the single top quark or the top quark pair signature. No significant deviations with respect to the standard model predictions are observed. The results are interpreted in the context of a simplified model in which a scalar or pseudoscalar mediator particle couples to a top quark and subsequently decays into dark matter particles. Scalar and pseudoscalar mediator particles with masses below 290 and 300 GeV, respectively, are excluded at 95% confidence level, assuming a dark matter particle mass of 1 GeV and mediator couplings to fermions and dark matter particles equal to unity. Keywords: Dark matter; Hadron-Hadron scattering (experiments); Top physics

Published
2019

158. Search for beyond the standard model Higgs bosons decaying into a bb‾ pair in pp collisions at √s=13 TeV

Author

Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Lincoln Laboratory, Massachusetts Institute of Technology. Department of Mechanical Engineering, Abercrombie, Daniel Robert, Allen, Benjamin E., Azzolini, Virginia, Barbieri, Richard Alexander, Baty, Austin Alan, Bauer, Gerry P, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Levin, Andrew (Andrew Michael), Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, Sruthi A., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, Wyslouch, Boleslaw, Shi, Zhaozhong, CMS Collaboration, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Lincoln Laboratory, Massachusetts Institute of Technology. Department of Mechanical Engineering, Abercrombie, Daniel Robert, Allen, Benjamin E., Azzolini, Virginia, Barbieri, Richard Alexander, Baty, Austin Alan, Bauer, Gerry P, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Levin, Andrew (Andrew Michael), Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, Sruthi A., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, Wyslouch, Boleslaw, Shi, Zhaozhong, and CMS Collaboration

Abstract

A search for Higgs bosons that decay into a bottom quark-antiquark pair and are accompanied by at least one additional bottom quark is performed with the CMS detector. The data analyzed were recorded in proton-proton collisions at a centre-of-mass energy of s√=13 TeV at the LHC, corresponding to an integrated luminosity of 35.7 fb⁻¹. The final state considered in this analysis is particularly sensitive to signatures of a Higgs sector beyond the standard model, as predicted in the generic class of two Higgs doublet models (2HDMs). No signal above the standard model background expectation is observed. Stringent upper limits on the cross section times branching fraction are set for Higgs bosons with masses up to 1300 GeV. The results are interpreted within several MSSM and 2HDM scenarios. Keywords: Beyond Standard Model; Hadron-Hadron scattering (experiments); Higgs physics

Published
2019

159. Performance of the CMS muon detector and muon reconstruction with proton-proton collisions at √s = 13 TeV

Author

Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Mechanical Engineering, Abercrombie, Daniel Robert, Allen, Brandon Leigh, Azzolini, Virginia, Barbieri, Richard Alexander, Baty, Austin Alan, Bauer, Gerry P, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Levine, Alan M, Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, S., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, Wyslouch, Boleslaw, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Mechanical Engineering, Abercrombie, Daniel Robert, Allen, Brandon Leigh, Azzolini, Virginia, Barbieri, Richard Alexander, Baty, Austin Alan, Bauer, Gerry P, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Levine, Alan M, Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, S., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, and Wyslouch, Boleslaw

Abstract

The CMS muon detector system, muon reconstruction software, and high-level trigger underwent significant changes in 2013-2014 in preparation for running at higher LHC collision energy and instantaneous luminosity. The performance of the modified system is studied using proton-proton collision data at center-of-mass energy √s = 13 TeV, collected at the LHC in 2015 and 2016. The measured performance parameters, including spatial resolution, efficiency, and timing, are found to meet all design specifications and are well reproduced by simulation. Despite the more challenging running conditions, the modified muon system is found to perform as well as, and in many aspects better than, previously. We dedicate this paper to the memory of Prof. Alberto Benvenuti, whose work was fundamental for the CMS muon detector.

Published
2019

160. Time reconstruction and performance of the CMS electromagnetic calorimeter

Author

Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Alver, Burak Han, Bauer, Gerry P, Bendavid, Joshua L., Busza, Wit, Butz, Erik M., Cali, Ivan Amos, Chan, M., D'Enterria, David, Everaerts, Pieter Bruno Bart, Gomez-Ceballos, Guillelmo, Hahn, Kristian Allan, Harris, Philip Coleman, Jaditz, Stephen Hunter, Kim, Y., Klute, Markus, Lee, Youjin, Li, W., Loizides, Constantinos, Ma, T., Miller, M., Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Rudolph, Matthew Scott, Stephans, George S. F., Sumorok, Konstanty C, Sung, K., Vaurynovich, Siarhei S., Wenger, Edward Allen, Wyslouch, Boleslaw, Xie, Si, Yilmaz, Yetkin, Yoon, A. S., Nahn, Steven, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Alver, Burak Han, Bauer, Gerry P, Bendavid, Joshua L., Busza, Wit, Butz, Erik M., Cali, Ivan Amos, Chan, M., D'Enterria, David, Everaerts, Pieter Bruno Bart, Gomez-Ceballos, Guillelmo, Hahn, Kristian Allan, Harris, Philip Coleman, Jaditz, Stephen Hunter, Kim, Y., Klute, Markus, Lee, Youjin, Li, W., Loizides, Constantinos, Ma, T., Miller, M., Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Rudolph, Matthew Scott, Stephans, George S. F., Sumorok, Konstanty C, Sung, K., Vaurynovich, Siarhei S., Wenger, Edward Allen, Wyslouch, Boleslaw, Xie, Si, Yilmaz, Yetkin, Yoon, A. S., and Nahn, Steven

Abstract

The resolution and the linearity of time measurements made with the CMS electromagnetic calorimeter are studied with samples of data from test beam electrons, cosmic rays, and beam-produced muons. The resulting time resolution measured by lead tungstate crystals is better than 100 ps for energy deposits larger than 10 GeV. Crystal-to-crystal synchronization with a precision of 500 ps is performed using muons produced with the first LHC beams in 2008.

Published
2019

161. Search for dark matter in proton-proton collisions at 8 TeV with missing transverse momentum and vector boson tagged jets

Author

Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Abercrombie, Daniel Robert, Allen, Brandon Leigh, Apyan, Aram, Barbieri, Richard Alexander, Baty, Austin Alan, Bi, Ran, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, Demiragli, Zeynep, Di Matteo, Leonardo, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Hsu, Dylan George, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Krajczar, Krisztian F., Lai, Yue Shi, Lee, Youjin, Levin, A., Luckey Jr, P David, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, S., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Varma, Mukund Madhav, Velicanu, Dragos Alexandru, Veverka, Jan, Wang, Jing, Wang, Ta-Wei, Wyslouch, Boleslaw, Yang, Ming, Wyslouch, Victoria, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Abercrombie, Daniel Robert, Allen, Brandon Leigh, Apyan, Aram, Barbieri, Richard Alexander, Baty, Austin Alan, Bi, Ran, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, Demiragli, Zeynep, Di Matteo, Leonardo, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Hsu, Dylan George, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Krajczar, Krisztian F., Lai, Yue Shi, Lee, Youjin, Levin, A., Luckey Jr, P David, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, S., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Varma, Mukund Madhav, Velicanu, Dragos Alexandru, Veverka, Jan, Wang, Jing, Wang, Ta-Wei, Wyslouch, Boleslaw, Yang, Ming, and Wyslouch, Victoria

Abstract

A search is presented for an excess of events with large missing transverse momentum in association with at least one highly energetic jet, in a data sample of proton-proton collisions at a centre-of-mass energy of 8 TeV. The data correspond to an integrated luminosity of 19.7 fb⁻¹ collected by the CMS experiment at the LHC. The results are interpreted using a set of simplified models for the production of dark matter via a scalar, pseudoscalar, vector, or axial vector mediator. Additional sensitivity is achieved by tagging events consistent with the jets originating from a hadronically decaying vector boson. This search uses jet substructure techniques to identify hadronically decaying vector bosons in both Lorentz-boosted and resolved scenarios. This analysis yields improvements of 80% in terms of excluded signal cross sections with respect to the previous CMS analysis using the same data set. No significant excess with respect to the standard model expectation is observed and limits are placed on the parameter space of the simplified models. Mediator masses between 80 and 400 GeV in the scalar and pseudoscalar models, and up to 1.5 TeV in the vector and axial vector models, are excluded.[Figure not available: see fulltext.] Keywords: Dark matter; Hadron-Hadron scattering (experiments)

Published
2019

162. Measurement of the muon stopping power in lead tungstate

Author

Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Alver, Burak Han, Bauer, Gerry P, Bendavid, Joshua L., Busza, Wit, Butz, Erik M., Cali, Ivan Amos, Chan, M., D'Enterria, David, Everaerts, Pieter Bruno Bart, Gomez-Ceballos, Guillelmo, Hahn, Kristian Allan, Harris, Philip Coleman, Jaditz, Stephen Hunter, Kim, Y., Klute, Markus, Lee, Youjin, Li, W., Loizides, Constantinos, Miller, M., Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Rudolph, Matthew Scott, Stephans, George S. F., Sumorok, Konstanty C, Sung, K., Vaurynovich, Siarhei S., Wenger, Edward Allen, Wyslouch, Boleslaw, Xie, S., Yilmaz, Yetkin, Yoon, A.S., CMS Collaboration, Ma. T., Nahn, Steven, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Alver, Burak Han, Bauer, Gerry P, Bendavid, Joshua L., Busza, Wit, Butz, Erik M., Cali, Ivan Amos, Chan, M., D'Enterria, David, Everaerts, Pieter Bruno Bart, Gomez-Ceballos, Guillelmo, Hahn, Kristian Allan, Harris, Philip Coleman, Jaditz, Stephen Hunter, Kim, Y., Klute, Markus, Lee, Youjin, Li, W., Loizides, Constantinos, Miller, M., Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Rudolph, Matthew Scott, Stephans, George S. F., Sumorok, Konstanty C, Sung, K., Vaurynovich, Siarhei S., Wenger, Edward Allen, Wyslouch, Boleslaw, Xie, S., Yilmaz, Yetkin, Yoon, A.S., CMS Collaboration, Ma. T., and Nahn, Steven

Abstract

A large sample of cosmic ray events collected by the CMS detector is exploited to measure the specific energy loss of muons in the lead tungstate (PbWO₄) of the electromagnetic calorimeter. The measurement spans a momentum range from 5 GeV/c to 1 TeV/c. The results are consistent with the expectations over the entire range. The calorimeter energy scale, set with 120 GeV/c electrons, is validated down to the sub-GeV region using energy deposits, of order 100 MeV, associated with low-momentum muons. The muon critical energy in PbWO₄ is measured to be 160⁺⁵₋₆±8 GeV, in agreement with expectations. This is the first experimental determination of muon critical energy.

Published
2019

163. Network Dependence Can Lead to Spurious Associations and Invalid Inference.

Author

Lee, Youjin and Ogburn, Elizabeth L.

Subjects
*SOCIAL networks, *CORONARY disease, *PEER pressure, *INFERENTIAL statistics, *CARDIAC research
Abstract

Researchers across the health and social sciences generally assume that observations are independent, even while relying on convenience samples that draw subjects from one or a small number of communities, schools, hospitals, etc. A paradigmatic example of this is the Framingham Heart Study (FHS). Many of the limitations of such samples are well-known, but the issue of statistical dependence due to social network ties has not previously been addressed. We show that, along with anticonservative variance estimation, this can result in spurious associations due to network dependence. Using a statistical test that we adapted from one developed for spatial autocorrelation, we test for network dependence in several of the thousands of influential papers that have been published using FHS data. Results suggest that some of the many decades of research on coronary heart disease, other health outcomes, and peer influence using FHS data may suffer from spurious associations, error-prone point estimates, and anticonservative inference due to unacknowledged network dependence. These issues are not unique to the FHS; as researchers in psychology, medicine, and beyond grapple with replication failures, this unacknowledged source of invalid statistical inference should be part of the conversation. for this article, including a standardized description of the materials available for reproducing the work, are available as an online supplement. [ABSTRACT FROM AUTHOR]

Published
2021
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165. Measurement of angular parameters from the decay B⁰→ K*⁰ μ⁺μ⁻ in proton–proton collisions at √s = 8 TeV

Author

Abercrombie, Daniel Robert, Allen, Brandon Leigh, Azzolini, Virginia, Barbieri, Richard Alexander, Baty, Austin Alan, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lai, Yue Shi, Lee, Youjin, Levine, Alan M, Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, S., Niu, X., Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, Wyslouch, Boleslaw, CMS Collaboration, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, and Massachusetts Institute of Technology. Department of Mechanical Engineering

Abstract

Angular distributions of the decay B⁰→ K*⁰ μ⁺μ⁻ are studied using a sample of proton–proton collisions at √s = 8 TeV collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 20.5fb⁻¹. An angular analysis is performed to determine the P1and P5′parameters, where the P5′parameter is of particular interest because of recent measurements that indicate a potential discrepancy with the standard model predictions. Based on a sample of 1397 signal events, the P1and P5′parameters are determined as a function of the dimuon invariant mass squared. The measurements are in agreement with predictions based on the standard model.

Published
2018

166. Search for beyond the standard model Higgs bosons decaying into a bb‾ pair in pp collisions at √s=13 TeV

Author

Abercrombie, Daniel Robert, Allen, Benjamin E., Azzolini, Virginia, Barbieri, Richard Alexander, Baty, Austin Alan, Bauer, Gerry P, Bi, Ran, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip Coleman, Hsu, Dylan George, Hu, Miao, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lee, Youjin, Levin, Andrew (Andrew Michael), Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, Sruthi A., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Stephans, George S. F., Sumorok, Konstanty C, Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, Wyslouch, Boleslaw, Shi, Zhaozhong, CMS Collaboration, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Lincoln Laboratory, and Massachusetts Institute of Technology. Department of Mechanical Engineering

Subjects
High Energy Physics::Lattice, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

A search for Higgs bosons that decay into a bottom quark-antiquark pair and are accompanied by at least one additional bottom quark is performed with the CMS detector. The data analyzed were recorded in proton-proton collisions at a centre-of-mass energy of s√=13 TeV at the LHC, corresponding to an integrated luminosity of 35.7 fb⁻¹. The final state considered in this analysis is particularly sensitive to signatures of a Higgs sector beyond the standard model, as predicted in the generic class of two Higgs doublet models (2HDMs). No signal above the standard model background expectation is observed. Stringent upper limits on the cross section times branching fraction are set for Higgs bosons with masses up to 1300 GeV. The results are interpreted within several MSSM and 2HDM scenarios. Keywords: Beyond Standard Model; Hadron-Hadron scattering (experiments); Higgs physics

Published
2018

168. Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

Author

Roth, Theodore L., primary, Li, P. Jonathan, additional, Nies, Jasper F., additional, Yu, Ruby, additional, Nguyen, Michelle L.T., additional, Lee, Youjin, additional, Apathy, Ryan, additional, Truong, Anna, additional, Hiatt, Joseph, additional, Wu, David, additional, Nguyen, David N., additional, Goodman, Daniel, additional, Bluestone, Jeffrey A., additional, Roybal, Kole, additional, Shifrut, Eric, additional, and Marson, Alexander, additional

Published
2019
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174. Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at √s=13 TeV

Author

Abercrombie, Daniel Robert, Allen, Brandon Leigh, Apyan, Aram, Azzolini, Virginia, Barbieri, Richard Alexander, Baty, Austin Alan, Bi, Ran, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, D'Alfonso, Mariarosaria, Demiragli, Zeynep, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Hsu, Dylan George, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Krajczar, Krisztian F., Lai, Yue Shi, Lee, Youjin, Levin, A., Luckey Jr, P David, Maier, Benedikt, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, S., Niu, Xinmei, Paus, Christoph M. E., Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Tatar, Kaya, Velicanu, Dragos Alexandru, Wang, Jing, Wang, Taiwei, Wyslouch, Boleslaw, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, and Massachusetts Institute of Technology. Department of Nuclear Science and Engineering

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

A search is performed for third-generation scalar leptoquarks and heavy right-handed neutrinos in events containing one electron or muon, one hadronically decaying τ lepton, and at least two jets, using a √s=13 TeV pp collision data sample corresponding to an integrated luminosity of 12.9 fb⁻¹ collected with the CMS detector at the LHC in 2016. The number of observed events is found to be in agreement with the standard model prediction. A limit is set at 95% confidence level on the product of the leptoquark pair production cross section and β², where β is the branching fraction of leptoquark decay to a τ lepton and a bottom quark. Assuming β = 1, third-generation leptoquarks with masses below 850 GeV are excluded at 95% confidence level. An additional search based on the same event topology involves heavy right-handed neutrinos, NR, and right-handed W bosons, WR, arising in a left-right symmetric extension of the standard model. In this search, WRbosons are assumed to decay to a tau lepton and NRfollowed by the decay of the NRto a tau lepton and an off-shell WRboson. Assuming the mass of the right-handed neutrino to be half of the mass of the right-handed W boson, WRboson masses below 2.9 TeV are excluded at 95% confidence level. These results improve on the limits from previous searches for third-generation leptoquarks and heavy right-handed neutrinos with τ leptons in the final state. Keywords: Beyond Standard Model; Hardron-Hadron scattering

Published
2017

175. Search for Supersymmetry in the Vector-Boson Fusion Topology in Proton-Proton Collisions √s = 8TeV

Author

Apyan, Aram, Barbieri, Richard Alexander, Baty, Austin Alan, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, Demiragli, Zeynep, Di Matteo, Leonardo, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Gulhan, Doga Can, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lai, Yue Shi, Lee, Youjin, Levin, Amy Elizabeth, Luckey Jr, P David, McGinn, Christopher Francis, Mironov, Camelia Maria, Niu, Xinmei, Paus, Christoph M. E., Ralph, Duncan Kelley, Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Varma, Mukund Madhav, Velicanu, Dragos Alexandru, Veverka, Jan, Wang, Jing, Wang, Ta-Wei, Wyslouch, Boleslaw, Yang, Ming, Wyslouch, Victoria, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Apyan, Aram, Barbieri, Richard Alexander, Baty, Austin Alan, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, Demiragli, Zeynep, Di Matteo, Leonardo, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Gulhan, Doga Can, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lai, Yue Shi, Lee, Youjin, Levin, Amy Elizabeth, Luckey Jr, P David, McGinn, Christopher Francis, Mironov, Camelia Maria, Niu, Xinmei, Paus, Christoph M. E., Ralph, Duncan Kelley, Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Varma, Mukund Madhav, Velicanu, Dragos Alexandru, Veverka, Jan, Wang, Jing, Wang, Ta-Wei, Wyslouch, Boleslaw, Yang, Ming, and Wyslouch, Victoria

Published
2015

178. Dissecting the genetic networks that control regulatory T cell stability using pooled CRISPR screens

Author

Cortez, Jessica T., primary, Shifrut, Eric, additional, Lee, Youjin, additional, Mumbach, Maxwell R., additional, Satpathy, Ansuman T., additional, Granja, Jeffrey, additional, Subramaniam, Meena, additional, Roth, Theodore, additional, Simeonov, Dimitre, additional, Ye, Chun J., additional, Chang, Howard Y., additional, Van Gool, Frederic, additional, and Marson, Alexander, additional

Published
2018
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181. TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations

Author

Lee, YouJin, primary, Jonson, Per Harald, additional, Sarparanta, Jaakko, additional, Palmio, Johanna, additional, Sarkar, Mohona, additional, Vihola, Anna, additional, Evilä, Anni, additional, Suominen, Tiina, additional, Penttilä, Sini, additional, Savarese, Marco, additional, Johari, Mridul, additional, Minot, Marie-Christine, additional, Hilton-Jones, David, additional, Maddison, Paul, additional, Chinnery, Patrick, additional, Reimann, Jens, additional, Kornblum, Cornelia, additional, Kraya, Torsten, additional, Zierz, Stephan, additional, Sue, Carolyn, additional, Goebel, Hans, additional, Azfer, Asim, additional, Ralston, Stuart H., additional, Hackman, Peter, additional, Bucelli, Robert C., additional, Taylor, J. Paul, additional, Weihl, Conrad C., additional, and Udd, Bjarne, additional

Published
2018
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184. Handbook of matching and weighting adjustments for causal inference by José R. Zubizarreta, Elizabeth A. Stuart, Dylan S. Small, and Paul R. Rosenbaum, Chapman and Hall/CRC, 2023, ISBN: 9781003102670, https://www.routledge.com/Handbook-of-matching-and-weighting-adjustments-for-causal-inference/Zubizarreta-Stuart-Small-Rosenbaum/p/book/9781003102670

Author

Lee, Youjin

Subjects
*CAUSAL inference, *SURVIVAL rate, *SEBASTES marinus, *BIOMETRY, *SCIENTIFIC observation
Abstract

The text discusses the importance of uncovering causal relationships between treatments and outcomes in social sciences, public health, and medicine. It introduces diverse causal inference methods used in observational studies to adjust for differences between treated and control groups. The book is structured into three main parts focusing on matching, weighting, machine learning, and Bayesian approaches, providing a comprehensive collection of recent causal inference methods for researchers and educators in related fields. [Extracted from the article]

Published
2024
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185. Effect of Thermal Fluctuations on the Radiative Rate in Core/Shell Quantum Dots.

Author

Balan, Arunima D, Balan, Arunima D, Eshet, Hagai, Olshansky, Jacob H, Lee, Youjin V, Rabani, Eran, Alivisatos, A Paul, Balan, Arunima D, Balan, Arunima D, Eshet, Hagai, Olshansky, Jacob H, Lee, Youjin V, Rabani, Eran, and Alivisatos, A Paul

Abstract

The effect of lattice fluctuations and electronic excitations on the radiative rate is demonstrated in CdSe/CdS core/shell spherical quantum dots (QDs). Using a combination of time-resolved photoluminescence spectroscopy and atomistic simulations, we show that lattice fluctuations can change the radiative rate over the temperature range from 78 to 300 K. We posit that the presence of the core/shell interface plays a significant role in dictating this behavior. We show that the other major factor that underpins the change in radiative rate with temperature is the presence of higher energy states corresponding to electron excitation into the shell. These effects should be present in other core/shell samples and should also affect other excited state rates, such as the rate of Auger recombination or the rate of charge transfer.

Published
2017

186. Temperature-Dependent Hole Transfer from Photoexcited Quantum Dots to Molecular Species: Evidence for Trap-Mediated Transfer.

Author

Olshansky, Jacob H, Olshansky, Jacob H, Balan, Arunima D, Ding, Tina X, Fu, Xiao, Lee, Youjin V, Alivisatos, A Paul, Olshansky, Jacob H, Olshansky, Jacob H, Balan, Arunima D, Ding, Tina X, Fu, Xiao, Lee, Youjin V, and Alivisatos, A Paul

Abstract

The effect of temperature on the rate of hole transfer from photoexcited quantum dots (QDs) is investigated by measuring the driving force dependence of the charge transfer rate for different sized QDs across a range of temperatures from 78 to 300 K. Spherical CdSe/CdS core/shell QDs were used with a series of ferrocene-derived molecular hole acceptors with an 800 meV range in electrochemical potential. Time-resolved photoluminescence measurements and photoluminescence quantum yield measurements in an integrating sphere were both performed from 78 to 300 K to obtain temperature-dependent rates for a series of driving forces as dictated by the nature of the molecular acceptor. For both QD sizes studied and all ligands, the Arrhenius plot of hole transfer exhibited an activated (linear) regime at higher temperatures and a temperature-independent regime at low temperatures. The extracted activation energies in the high-temperature regime were consistent across all ligands for a given QD size. This observation is not consistent with direct charge transfer from the QD valence band to the ferrocene acceptor. Instead, a model in which charge transfer is mediated by a shallow and reversible trap more accurately fits the experimental results. Implications for this observed trap-mediated transfer are discussed including as a strategy to more efficiently extract charge from QDs.

Published
2017

187. Search for dark matter and unparticles produced in association with a Z boson in proton-proton collisions at √s = 8 TeV

Author

Massachusetts Institute of Technology. Department of Nuclear Science and Engineering, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Apyan, Aram, Barbieri, Richard Alexander, Baty, Austin Alan, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, Demiragli, Zeynep, Di Matteo, Leonardo, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Gulhan, Doga Can, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lai, Yue Shi, Lee, Youjin, Levin, Andrew Michael, Luckey Jr, P David, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, Siddharth Madhavan, Niu, Xinmei, Paus, Christoph M. E., Ralph, Duncan Kelley, Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Varma, Mukund Madhav, Velicanu, Dragos Alexandru, Veverka, Jan, Wang, Jing, Wang, Ta-Wei, Wyslouch, Boleslaw, Yang, Ming, Wyslouch, Victoria, Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Asilar, E., Bergauer, T., Brandstetter, J., Brondolin, E., Dragicevic, M., Erö, J., Flechl, M., Friedl, M., Frühwirth, R., Ghete, V. M., Hartl, C., Hörmann, N., Hrubec, J., Jeitler, M., Knünz, V., König, A., Krammer, M., Krätschmer, I., Liko, D., Matsushita, T., Mikulec, I., Rabady, D., Rahbaran, B., Rohringer, H., Schieck, J., Schöfbeck, R., Strauss, J., Treberer-Treberspurg, W., Waltenberger, W., Wulz, C.-E., Mossolov, V., Shumeiko, N., Suarez Gonzalez, J., Alderweireldt, S., Cornelis, T., De Wolf, E. A., Janssen, X., Knutsson, A., Lauwers, J., Luyckx, S., Van De Klundert, M., Van Haevermaet, H., Van Mechelen, P., Van Remortel, N., Van Spilbeeck, A., Abu Zeid, S., Blekman, F., D’Hondt, J., Daci, N., De Bruyn, I., Deroover, K., Heracleous, N., Keaveney, J., Lowette, S., Moreels, L., Olbrechts, A., Python, Q., Strom, D., Tavernier, S., Van Doninck, W., Van Mulders, P., Van Onsem, G. P., Van Parijs, I., Barria, P., Brun, H., Caillol, C., Clerbaux, B., De Lentdecker, G., Fasanella, G., Favart, L., Grebenyuk, A., Karapostoli, G., Lenzi, T., Léonard, A., Maerschalk, T., Marinov, A., Perniè, L., Randle-conde, A., Seva, T., Vander Velde, C., Vanlaer, P., Yonamine, R., Zenoni, F., Zhang, F., Beernaert, K., Benucci, L., Cimmino, A., Crucy, S., Dobur, D., Fagot, A., Garcia, G., Gul, M., Mccartin, J., Ocampo Rios, A. A., Poyraz, D., Ryckbosch, D., Salva, S., Sigamani, M., Tytgat, M., Van Driessche, W., Yazgan, E., Zaganidis, N., Basegmez, S., Beluffi, C., Bondu, O., Brochet, S., Bruno, G., Caudron, A., Ceard, L., Da Silveira, G. G., Delaere, C., Favart, D., Forthomme, L., Giammanco, A., Hollar, J., Jafari, A., Jez, P., Komm, M., Lemaitre, V., Mertens, A., Musich, M., Nuttens, C., Perrini, L., Pin, A., Piotrzkowski, K., Popov, A., Quertenmont, L., Selvaggi, M., Vidal Marono, M., Beliy, N., Hammad, G. H., Aldá Júnior, W. L., Alves, F. L., Alves, G. A., Brito, L., Correa Martins Junior, M., Hamer, M., Hensel, C., Mora Herrera, C., Moraes, A., Pol, M. E., Rebello Teles, P., Belchior Batista Das Chagas, E., Carvalho, W., Chinellato, J., Custódio, A., Da Costa, E. M., De Jesus Damiao, D., De Oliveira Martins, C., Fonseca De Souza, S., Huertas Guativa, L. M., Malbouisson, H., Matos Figueiredo, D., Mundim, L., Nogima, H., Prado Da Silva, W. L., Santoro, A., Sznajder, A., Tonelli Manganote, E. J., Vilela Pereira, A., Ahuja, S., Bernardes, C. A., De Souza Santos, A., Dogra, S., Tomei, Fernandez Perez T. R., Gregores, E. M., Mercadante, P. G., Moon, C. S., Novaes, S. F., Padula, Sandra S., Romero Abad, D., Ruiz Vargas, J. C., Aleksandrov, A., Hadjiiska, R., Iaydjiev, P., Rodozov, M., Stoykova, S., Sultanov, G., Vutova, M., Dimitrov, A., Glushkov, I., Litov, L., Pavlov, B., Petkov, P., Ahmad, M., Bian, J. G., Chen, G. M., Chen, H. S., Chen, M., Cheng, T., Du, R., Jiang, C. H., Plestina, R., Romeo, F., Shaheen, S. M., Spiezia, A., Tao, J., Wang, C., Wang, Z., Zhang, H., Asawatangtrakuldee, C., Ban, Y., Li, Q., Liu, S., Mao, Y., Qian, S. J., Wang, D., Xu, Z., Avila, C., Cabrera, A., Chaparro Sierra, L. F., Florez, C., Gomez, J. P., Gomez Moreno, B., Sanabria, J. C., Godinovic, N., Lelas, D., Puljak, I., Ribeiro Cipriano, P. M., Antunovic, Z., Kovac, M., Brigljevic, V., Kadija, K., Luetic, J., Micanovic, S., Sudic, L., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Bodlak, M., Finger, M., Assran, Y., Elgammal, S., Ellithi Kamel, A., Mahmoud, M. A., Mohammed, Y., Calpas, B., Kadastik, M., Murumaa, M., Raidal, M., Tiko, A., Veelken, C., Eerola, P., Pekkanen, J., Voutilainen, M., Härkönen, J., Karimäki, V., Kinnunen, R., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Luukka, P., Mäenpää, T., Peltola, T., Tuominen, E., Tuominiemi, J., Tuovinen, E., Wendland, L., Talvitie, J., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. L., Favaro, C., Ferri, F., Ganjour, S., Givernaud, A., Gras, P., Hamel de Monchenault, G., Jarry, P., Locci, E., Machet, M., Malcles, J., Rander, J., Rosowsky, A., Titov, M., Zghiche, A., Antropov, I., Baffioni, S., Beaudette, F., Busson, P., Cadamuro, L., Chapon, E., Charlot, C., Dahms, T., Davignon, O., Filipovic, N., Granier de Cassagnac, R., Jo, M., Lisniak, S., Mastrolorenzo, L., Miné, P., Naranjo, I. N., Nguyen, M., Ochando, C., Ortona, G., Paganini, P., Pigard, P., Regnard, S., Salerno, R., Sauvan, Sirois, Y., Strebler, T., Yilmaz, Y., Zabi, A., Agram, J.-L., Andrea, J., Aubin, A., Bloch, D., Brom, J.-M., Buttignol, M., Chabert, E. C., Chanon, N., Collard, C., Conte, E., Coubez, X., Fontaine, J.-C., Gelé, D., Goerlach, U., Goetzmann, C., Le Bihan, A.-C., Merlin, J. A., Skovpen, K., Van Hove, P., Gadrat, S., Beauceron, S., Bernet, C., Boudoul, G., Bouvier, E., Carrillo Montoya, C. A., Chierici, R., Contardo, D., Courbon, B., Depasse, P., El Mamouni, H., Fan, J., Fay, J., Gascon, S., Gouzevitch, M., Ille, B., Lagarde, F., Laktineh, I. B., Lethuillier, M., Mirabito, L., Pequegnot, A. L., Perries, S., Ruiz Alvarez, J. D., Sabes, D., Sgandurra, L., Sordini, V., Vander Donckt, M., Verdier, P., Viret, S., Toriashvili, T., Tsamalaidze, Z., Autermann, C., Beranek, S., Edelhoff, M., Feld, L., Heister, A., Kiesel, M. K., Klein, K., Lipinski, M., Ostapchuk, A., Preuten, M., Raupach, F., Schael, S., Schulte, J. F., Verlage, T., Weber, H., Wittmer, B., Zhukov, V., Ata, M., Brodski, M., Dietz-Laursonn, E., Duchardt, D., Endres, M., Erdmann, M., Erdweg, S., Esch, T., Fischer, R., Güth, A., Hebbeker, T., Heidemann, C., Hoepfner, K., Knutzen, S., Kreuzer, P., Merschmeyer, M., Meyer, A., Millet, P., Olschewski, M., Padeken, K., Papacz, P., Pook, T., Radziej, M., Reithler, H., Rieger, M., Scheuch, F., Sonnenschein, L., Teyssier, D., Thüer, S., Cherepanov, V., Erdogan, Y., Flügge, G., Geenen, H., Geisler, M., Hoehle, F., Kargoll, B., Kress, T., Kuessel, Y., Künsken, A., Lingemann, J., Nehrkorn, A., Nowack, A., Nugent, I. M., Pistone, C., Pooth, O., Stahl, A., Aldaya Martin, M., Asin, I., Bartosik, N., Behnke, O., Behrens, U., Bell, A. J., Borras, K., Burgmeier, A., Campbell, A., Choudhury, S., Costanza, F., Diez Pardos, C., Dolinska, G., Dooling, S., Dorland, T., Eckerlin, G., Eckstein, D., Eichhorn, T., Flucke, G., Gallo, E., Garay Garcia, J., Geiser, A., Gizhko, A., Gunnellini, P., Hauk, J., Hempel, M., Jung, H., Kalogeropoulos, A., Karacheban, O., Kasemann, M., Katsas, P., Kieseler, J., Kleinwort, C., Korol, I., Lange, W., Leonard, J., Lipka, K., Lobanov, A., Lohmann, W., Mankel, R., Marfin, I., Melzer-Pellmann, I.-A., Meyer, A. B., Mittag, G., Mnich, J., Mussgiller, A., Naumann-Emme, S., Nayak, A., Ntomari, E., Perrey, H., Pitzl, D., Placakyte, R., Raspereza, A., Roland, B., Sahin, M. Ö., Saxena, P., Schoerner-Sadenius, T., Schröder, M., Seitz, C., Spannagel, S., Trippkewitz, K. D., Walsh, R., Wissing, C., Blobel, V., Centis Vignali, M., Draeger, A. R., Erfle, J., Garutti, E., Goebel, K., Gonzalez, D., Görner, M., Haller, J., Hoffmann, M., Höing, R. S., Junkes, A., Klanner, R., Kogler, R., Kovalchuk, N., Lapsien, T., Lenz, T., Marchesini, I., Marconi, D., Meyer, M., Nowatschin, D., Ott, J., Pantaleo, F., Peiffer, T., Perieanu, A., Pietsch, N., Poehlsen, J., Rathjens, D., Sander, C., Scharf, C., Schettler, H., Schleper, P., Schlieckau, E., Schmidt, A., Schwandt, J., Sola, V., Stadie, H., Steinbrück, G., Tholen, H., Troendle, D., Usai, E., Vanelderen, L., Vanhoefer, A., Vormwald, B., Akbiyik, M., Barth, C., Baus, C., Berger, J., Böser, C., Butz, E., Chwalek, T., Colombo, F., De Boer, W., Descroix, A., Dierlamm, A., Fink, S., Frensch, F., Friese, R., Giffels, M., Gilbert, A., Haitz, D., Hartmann, F., Heindl, S. M., Husemann, U., Katkov, I., Kornmayer, A., Lobelle Pardo, P., Maier, B., Mildner, H., Mozer, M. U., Müller, T., Müller, Th., Plagge, M., Quast, G., Rabbertz, K., Röcker, S., Roscher, F., Sieber, G., Simonis, H. J., Stober, F. M., Ulrich, R., Wagner-Kuhr, J., Wayand, S., Weber, M., Weiler, T., Wöhrmann, C., Wolf, R., Anagnostou, G., Daskalakis, G., Geralis, T., Giakoumopoulou, V. A., Kyriakis, A., Loukas, D., Psallidas, A., Topsis-Giotis, I., Agapitos, A., Kesisoglou, S., Panagiotou, A., Saoulidou, N., Tziaferi, E., Evangelou, I., Flouris, G., Foudas, C., Kokkas, P., Loukas, N., Manthos, N., Papadopoulos, I., Paradas, E., Strologas, J., Bencze, G., Hajdu, C., Hazi, A., Hidas, P., Horvath, D., Sikler, F., Veszpremi, V., Vesztergombi, G., Zsigmond, A. J., Beni, N., Czellar, S., Karancsi, J., Molnar, J., Szillasi, Z., Bartók, M., Makovec, A., Raics, P., Trocsanyi, Z. L., Ujvari, B., Mal, P., Mandal, K., Sahoo, D. K., Sahoo, N., Swain, S. K., Bansal, S., Beri, S. B., Bhatnagar, V., Chawla, R., Gupta, R., Bhawandeep, U., Kalsi, A. K., Kaur, A., Kaur, M., Kumar, R., Mehta, A., Mittal, M., Singh, J. B., Walia, G., Kumar, Ashok, Bhardwaj, A., Choudhary, B. C., Garg, R. B., Kumar, A., Malhotra, S., Naimuddin, M., Nishu, N., Ranjan, K., Sharma, R., Sharma, V., Bhattacharya, S., Chatterjee, K., Dey, S., Dutta, S., Jain, Sa., Majumdar, N., Modak, A., Mondal, K., Mukherjee, S., Mukhopadhyay, S., Roy, A., Roy, D., Roy Chowdhury, S., Sarkar, S., Sharan, M., Abdulsalam, A., Chudasama, R., Dutta, D., Jha, V., Kumar, V., Mohanty, A. K., Pant, L. M., Shukla, P., Topkar, A., Aziz, T., Banerjee, S., Bhowmik, S., Chatterjee, R. M., Dewanjee, R. K., Dugad, S., Ganguly, S., Ghosh, S., Guchait, M., Gurtu, A., Kole, G., Kumar, S., Mahakud, B., Maity, M., Majumder, G., Mazumdar, K., Mitra, S., Mohanty, G. B., Parida, B., Sarkar, T., Sur, N., Sutar, B., Wickramage, N., Chauhan, S., Dube, S., Kothekar, K., Sharma, S., Bakhshiansohi, H., Behnamian, H., Etesami, S. M., Fahim, A., Goldouzian, R., Khakzad, M., Mohammadi Najafabadi, M., Naseri, M., Paktinat Mehdiabadi, S., Rezaei Hosseinabadi, F., Safarzadeh, B., Zeinali, M., Felcini, M., Grunewald, M., Abbrescia, M., Calabria, C., Caputo, C., Colaleo, A., Creanza, D., Cristella, L., De Filippis, N., De Palma, M., Fiore, L., Iaselli, G., Maggi, G., Maggi, M., Miniello, G., My, S., Nuzzo, S., Pompili, A., Pugliese, G., Radogna, R., Ranieri, A., Selvaggi, G., Silvestris, L., Venditti, R., Verwilligen, P., Abbiendi, G., Battilana, C., Benvenuti, A. C., Bonacorsi, D., Braibant-Giacomelli, S., Brigliadori, L., Campanini, R., Capiluppi, P., Castro, A., Cavallo, F. R., Chhibra, S. S., Codispoti, G., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Grandi, C., Guiducci, L., Marcellini, S., Masetti, G., Montanari, A., Navarria, F. L., Perrotta, A., Rossi, A. M., Rovelli, T., Siroli, G. 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Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Apyan, Aram, Barbieri, Richard Alexander, Baty, Austin Alan, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, Demiragli, Zeynep, Di Matteo, Leonardo, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Gulhan, Doga Can, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lai, Yue Shi, Lee, Youjin, Levin, Andrew Michael, Luckey Jr, P David, Marini, Andrea Carlo, McGinn, Christopher Francis, Mironov, Camelia Maria, Narayanan, Siddharth Madhavan, Niu, Xinmei, Paus, Christoph M. E., Ralph, Duncan Kelley, Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Varma, Mukund Madhav, Velicanu, Dragos Alexandru, Veverka, Jan, Wang, Jing, Wang, Ta-Wei, Wyslouch, Boleslaw, Yang, Ming, Wyslouch, Victoria, Khachatryan, V., Sirunyan, A. 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Abstract

A search for evidence of particle dark matter (DM) and unparticle production at the LHC has been performed using events containing two charged leptons, consistent with the decay of a Z boson, and large missing transverse momentum. This study is based on data collected with the CMS detector corresponding to an integrated luminosity of 19.7 fb[superscript −1] of pp collisions at the LHC at a center-of-mass energy of 8 TeV. No significant excess of events is observed above the number expected from the standard model contributions. The results are interpreted in terms of 90% confidence level limits on the DM-nucleon scattering cross section, as a function of the DM particle mass, for both spin-dependent and spin-independent scenarios. Limits are set on the effective cutoff scale Λ, and on the annihilation rate for DM particles, assuming that their branching fraction to quarks is 100%. Additionally, the most stringent 95% confidence level limits to date on the unparticle model parameters are obtained.

Published
2017

188. Discovery of stimulation-responsive immune enhancers with CRISPR activation.

Author

Simeonov, Dimitre R, Simeonov, Dimitre R, Gowen, Benjamin G, Boontanrart, Mandy, Roth, Theodore L, Gagnon, John D, Mumbach, Maxwell R, Satpathy, Ansuman T, Lee, Youjin, Bray, Nicolas L, Chan, Alice Y, Lituiev, Dmytro S, Nguyen, Michelle L, Gate, Rachel E, Subramaniam, Meena, Li, Zhongmei, Woo, Jonathan M, Mitros, Therese, Ray, Graham J, Curie, Gemma L, Naddaf, Nicki, Chu, Julia S, Ma, Hong, Boyer, Eric, Van Gool, Frederic, Huang, Hailiang, Liu, Ruize, Tobin, Victoria R, Schumann, Kathrin, Daly, Mark J, Farh, Kyle K, Ansel, K Mark, Ye, Chun J, Greenleaf, William J, Anderson, Mark S, Bluestone, Jeffrey A, Chang, Howard Y, Corn, Jacob E, Marson, Alexander, Simeonov, Dimitre R, Simeonov, Dimitre R, Gowen, Benjamin G, Boontanrart, Mandy, Roth, Theodore L, Gagnon, John D, Mumbach, Maxwell R, Satpathy, Ansuman T, Lee, Youjin, Bray, Nicolas L, Chan, Alice Y, Lituiev, Dmytro S, Nguyen, Michelle L, Gate, Rachel E, Subramaniam, Meena, Li, Zhongmei, Woo, Jonathan M, Mitros, Therese, Ray, Graham J, Curie, Gemma L, Naddaf, Nicki, Chu, Julia S, Ma, Hong, Boyer, Eric, Van Gool, Frederic, Huang, Hailiang, Liu, Ruize, Tobin, Victoria R, Schumann, Kathrin, Daly, Mark J, Farh, Kyle K, Ansel, K Mark, Ye, Chun J, Greenleaf, William J, Anderson, Mark S, Bluestone, Jeffrey A, Chang, Howard Y, Corn, Jacob E, and Marson, Alexander

Abstract

The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues. Systematic mapping of functional enhancers and their biological contexts is required to understand the mechanisms by which variation in non-coding genetic sequences contributes to disease. Functional enhancers can be mapped by genomic sequence disruption, but this approach is limited to the subset of enhancers that are necessary in the particular cellular context being studied. We hypothesized that recruitment of a strong transcriptional activator to an enhancer would be sufficient to drive target gene expression, even if that enhancer was not currently active in the assayed cells. Here we describe a discovery platform that can identify stimulus-responsive enhancers for a target gene independent of stimulus exposure. We used tiled CRISPR activation (CRISPRa) to synthetically recruit a transcriptional activator to sites across large genomic regions (more than 100 kilobases) surrounding two key autoimmunity risk loci, CD69 and IL2RA. We identified several CRISPRa-responsive elements with chromatin features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours an autoimmunity risk variant. Using engineered mouse models, we found that sequence perturbation of the disease-associated Il2ra enhancer did not entirely block Il2ra expression, but rather delayed the timing of gene activation in response to specific extracellular signals. Enhancer deletion skewed polarization of naive T cells towards a pro-inflammatory T helper (TH17) cell state and away from a regulatory T cell state. This integrated approach identifies functional enhancers and reveals how non-coding variation associated with human immune dysfunction alters context-specific gene programs.

Published
2017

189. Search for Supersymmetry in the Vector-Boson Fusion Topology in Proton-Proton Collisions √s = 8TeV

Author

Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Apyan, Aram, Barbieri, Richard Alexander, Baty, Austin Alan, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, Demiragli, Zeynep, Di Matteo, Leonardo, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Gulhan, Doga Can, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lai, Yue Shi, Lee, Youjin, Levin, Amy Elizabeth, Luckey Jr, P David, McGinn, Christopher Francis, Mironov, Camelia Maria, Niu, Xinmei, Paus, Christoph M. E., Ralph, Duncan Kelley, Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Varma, Mukund Madhav, Velicanu, Dragos Alexandru, Veverka, Jan, Wang, Jing, Wang, Ta-Wei, Wyslouch, Boleslaw, Yang, Ming, Wyslouch, Victoria, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Apyan, Aram, Barbieri, Richard Alexander, Baty, Austin Alan, Bierwagen, Katharina, Brandt, Stephanie Akemi, Busza, Wit, Cali, Ivan Amos, Demiragli, Zeynep, Di Matteo, Leonardo, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Gulhan, Doga Can, Iiyama, Yutaro, Innocenti, Gian Michele, Klute, Markus, Kovalskyi, Dmytro, Lai, Yue Shi, Lee, Youjin, Levin, Amy Elizabeth, Luckey Jr, P David, McGinn, Christopher Francis, Mironov, Camelia Maria, Niu, Xinmei, Paus, Christoph M. E., Ralph, Duncan Kelley, Roland, Christof E, Roland, Gunther M, Salfeld-Nebgen, Jakob Maxillian Henry, Stephans, George S. F., Sumorok, Konstanty C, Varma, Mukund Madhav, Velicanu, Dragos Alexandru, Veverka, Jan, Wang, Jing, Wang, Ta-Wei, Wyslouch, Boleslaw, Yang, Ming, and Wyslouch, Victoria

Published
2017

190. Diffusion tensor imaging of articular cartilage at 3T correlates with histology and biomechanics in a mechanical injury model

Author

Ferizi, Uran, Rossi, Ignacio, Lee, Youjin, Lendhey, Matin, Teplensky, Jason, Kennedy, Oran D., Kirsch, Thorsten, Bencardino, Jenny, and Raya, José G.

Subjects
Adult, Cartilage, Articular, Male, Fractures, Cartilage, Viscosity, Reproducibility of Results, Knee Injuries, Middle Aged, Sensitivity and Specificity, Article, Diffusion Tensor Imaging, Elastic Modulus, Image Interpretation, Computer-Assisted, Humans, Female, sense organs, Stress, Mechanical
Abstract

PURPOSE: We establish a mechanical injury model for articular cartilage to assess the sensitivity of diffusion tensor imaging (DTI) in detecting cartilage damage early in time. Mechanical injury provides a more realistic model of cartilage degradation compared with commonly-used enzymatic degradation. METHODS: Nine cartilage-on-bone samples were obtained from patients undergoing knee replacement. 3T DTI (0.18×0.18×1 mm(3)) was performed before, one week and two weeks after (control, mild and severe) injury, with a clinical Radial Spin-Echo DTI (RAISED) sequence used in our hospital. We performed stress-relaxation tests and used a quasilinear-viscoelastic (QLV) model to characterize cartilage mechanical properties. Serial histology sections were dyed with Safranin-O and given an OARSI grade. We then correlated the changes in DTI parameters with the changes in QLV-parameters and OARSI grades. RESULTS: After severe injury the mean diffusivity increased after one and two weeks, whereas the fractional anisotropy decreased after two weeks (p

Published
2016

191. Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

Author

Hu, Dan, primary, Notarbartolo, Samuele, additional, Croonenborghs, Tom, additional, Patel, Bonny, additional, Cialic, Ron, additional, Yang, Tun-Hsiang, additional, Aschenbrenner, Dominik, additional, Andersson, Karin M., additional, Gattorno, Marco, additional, Pham, Minh, additional, Kivisakk, Pia, additional, Pierre, Isabelle V., additional, Lee, Youjin, additional, Kiani, Karun, additional, Bokarewa, Maria, additional, Tjon, Emily, additional, Pochet, Nathalie, additional, Sallusto, Federica, additional, Kuchroo, Vijay K., additional, and Weiner, Howard L., additional

Published
2017
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192. 3D calcite heterostructures for dynamic and deformable mineralized matrices

Author

Yi, Jaeseok, primary, Wang, Yucai, additional, Jiang, Yuanwen, additional, Jung, Il Woong, additional, Liu, Wenjun, additional, De Andrade, Vincent, additional, Xu, Ruqing, additional, Parameswaran, Ramya, additional, Peters, Ivo R., additional, Divan, Ralu, additional, Xiao, Xianghui, additional, Sun, Tao, additional, Lee, Youjin, additional, Park, Won Il, additional, and Tian, Bozhi, additional

Published
2017
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193. Discovery of stimulation-responsive immune enhancers with CRISPR activation

Author

Simeonov, Dimitre R., primary, Gowen, Benjamin G., additional, Boontanrart, Mandy, additional, Roth, Theodore L., additional, Gagnon, John D., additional, Mumbach, Maxwell R., additional, Satpathy, Ansuman T., additional, Lee, Youjin, additional, Bray, Nicolas L., additional, Chan, Alice Y., additional, Lituiev, Dmytro S., additional, Nguyen, Michelle L., additional, Gate, Rachel E., additional, Subramaniam, Meena, additional, Li, Zhongmei, additional, Woo, Jonathan M., additional, Mitros, Therese, additional, Ray, Graham J., additional, Curie, Gemma L., additional, Naddaf, Nicki, additional, Chu, Julia S., additional, Ma, Hong, additional, Boyer, Eric, additional, Van Gool, Frederic, additional, Huang, Hailiang, additional, Liu, Ruize, additional, Tobin, Victoria R., additional, Schumann, Kathrin, additional, Daly, Mark J., additional, Farh, Kyle K., additional, Ansel, K. Mark, additional, Ye, Chun J., additional, Greenleaf, William J., additional, Anderson, Mark S., additional, Bluestone, Jeffrey A., additional, Chang, Howard Y., additional, Corn, Jacob E., additional, and Marson, Alexander, additional

Published
2017
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199. Discovery of an autoimmunity-associated IL2RA enhancer by unbiased targeting of transcriptional activation

Author

Simeonov, Dimitre R., primary, Gowen, Benjamin G., additional, Boontanrart, Mandy, additional, Roth, Theodore, additional, Lee, Youjin, additional, Chan, Alice, additional, Nguyen, Michelle L., additional, Gate, Rachel E., additional, Subramaniam, Meena, additional, Woo, Jonathan M., additional, Mitros, Therese, additional, Ray, Graham J., additional, Bray, Nicolas L., additional, Curie, Gemma L., additional, Naddaf, Nicki, additional, Boyer, Eric, additional, Van Gool, Frederic, additional, Schumann, Kathrin, additional, Daly, Mark J., additional, Fahr, Kyle K., additional, Ye, Chun, additional, Bluestone, Jeffrey A., additional, Anderson, Mark S., additional, Corn, Jacob E., additional, and Marson, Alexander, additional

Published
2016
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200. ChemInform Abstract: Application of a Palladium‐Catalyzed C—H Functionalization/Indolization Method to Syntheses of cis‐Trikentrin A and Herbindole B.

Author

Leal, Raul A., primary, Bischof, Caroline, additional, Lee, Youjin V., additional, Sawano, Shota, additional, McAtee, Christopher C., additional, Latimer, Luke N., additional, Russ, Zachary N., additional, Dueber, John E., additional, Yu, Jin‐Quan, additional, and Sarpong, Richmond, additional

Published
2016
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