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In most conventional forced-air systems, the guidelines for the air handling unit(AHU) discharge air temperature(DAT) are not fully established and thus AHU DAT are constantly fixed to a particular set-point, regardless of dynamic changes of operating variables. In this circumstance, this study aimed at developing a control algorithm that can operate a conventional VAV system with optimal set-points for the AHU DAT. Three-story office building was modeled using co-simulation technique between EnergyPlus and Matlab via BCVTB(Building Controls Virtual Test Bed). In addition, artificial neural network(ANN) model, which was designed to predict the cooling energy consumption for the upcoming next time-step, was embedded into the control algorithm using neural network toolbox within Matlab. By comparing the predicted energy for the different set-points of the AHU DAT, the control algorithm can determine the most energy-effective AHU DAT set-point to minimize the cooling energy. The results showed that the prediction accuracy between simulated and predicted outcomes turned out to have a low coefficient of variation root mean square error (CvRMSE) value of approximately 24%. In addition, the predictive control algorithm was able to significantly reduce cooling energy consumption by approximately 10%, compared to a conventional control strategy of fixing AHU DAT to 14°C.

Herein, we report the first study to create a three‐dimensional (3D) bioprinted artificial larynx for whole‐laryngeal replacement. Our 3D bio‐printed larynx was generated using extrusion‐based 3D bioprinter with rabbit's chondrocyte‐laden gelatin methacryloyl (GelMA)/glycidyl‐methacrylated hyaluronic acid (GMHA) hybrid bioink. We used a polycaprolactone (PCL) outer framework incorporated with pores to achieve the structural strength of printed constructs, as well as to provide a suitable microenvironment to support printed cells. Notably, we established a novel fluidics supply (FS) system that simultaneously supplies basal medium together with a 3D bioprinting process, thereby improving cell survival during the printing process. Our results showed that the FS system enhanced post‐printing cell viability, which enabled the generation of a large‐scale cell‐laden artificial laryngeal framework. Additionally, the incorporation of the PCL outer framework with pores and inner hydrogel provides structural stability and sufficient nutrient/oxygen transport. An animal study confirmed that the transplanted 3D bio‐larynx successfully maintained the airway. With further development, our new strategy holds great potential for fabricating human‐scale larynxes with in vivo‐like biological functions for laryngectomy patients. [ABSTRACT FROM AUTHOR]

Panax ginseng is a well-known herbal medicine in traditional Asian medicine, and wild ginseng is widely accepted to be more active than cultivated ginseng in chemoprevention. However, little has actually been reported on the difference between wild ginseng and cultivated ginseng. Thus, to identify and analyze those differences, we used suppressive subtraction hybridization (SSH) sequences with microarrays, realtime polymerase chain reaction (PCR), and reverse transcription PCRs (RT-PCRs). One of the clones isolated in this research was the chloroplast rpoC1 gene, a β subunit of RNA polymerase. Real-time RT-PCR results showed that the expression of the rpoC1 gene was significantly upregulated in wild ginseng as compared to cultivated ginseng, so, we conclude that the rpoC1 gene may be one of the important markers of wild ginseng.

Objectives:This study was performed to analyse the effects of Sweet Bee Venom(Sweet BV) on cardiovascular system in the conscious telemetered Beagle Dogs. Methods:All experiments were conducted at Biotoxtech Company, a non-clinical studies authorized institution, under the regulations of Good Laboratory Practice (GLP). Male Beagle dogs of 13-19 months old were chosen for the pilot study and surgical implantation was performed for conscious telemetered Beagle dogs. And after confirming condition of Beagle dogs was stable, Sweet BV was administered 4 times(first: 0.0 ㎎/㎏, 2nd: 0.01 ㎎/㎏, 3rd: 0.1 ㎎/㎏, and forth: 0.5 ㎎/㎏, one time/week) in thigh muscle of Beagle dogs. And blood pressure, heart rate, electrocardiography and clinical responses were measured. Equal amount of normal saline to the Sweet BV experiment groups was administered to the control group. 1. In the analysis of body weight and taking amount, Beagle dogs did not show significant changes. 2. In the clinical observation, responses of pain and edema were showed depend on dosage of Sweet BV. 3. In the analysis of blood pressure, treatment with Sweet BV did not show significant changes in the dosage of 0.01 ㎎/㎏, but in the dosage of 0.1 ㎎/㎏ and 0.5 ㎎/㎏, treatment with Sweet BV increased blood pressure significantly. 4. In the analysis of heart rate, treatment of Sweet BV did not show significant changes in all dosage and period. 5. In the analysis of electrocardiography, treatment of Sweet BV was not showed significant changes in all dosage and period. Conclusion:Above findings suggest that Sweet BV is relatively safe treatment in the cardiovascular system. But in the using of over dosage, Sweet BV may the cause of increasing blood pressure. Further studies on the subject should be conducted to yield more concrete evidences.

Objectives : This study was performed to developing orally administered analgesics and locally injected pharmacopuncture analgesics like opioids. Methods : Literary investigation on the origin of poppy (Papaver somniferum L) and other narcotics was conducted to examine the potential of developing orally administered analgesics and locally injected pharmacopuncture analgesics. Opium is a gum-like mass derived from air-dried white fluid of immature fruit of the poppy. Opium contains approximately 20 types of alkaloids including morphine, codeine, thebaine, papaverine and others. Natural opioids and synthetic alkaloid derivatives are the constituents of opioid analgesics and their effects and side-effects depend on the peculiarities of receptors. An extreme caution is required in the selection of proper dosage, proper analgesic types, and indications for successful pain management. Results and Discussion : With the enactment of "Narcotic control protocol", herbs such as cannibis and poppy are no longer available for use by Korean medicine doctors, and these doctors are faced with difficulty in managing severe pain in the clinical environment. A systematic consideration is inevitable for overcoming the limitation on these analgesics.

This study devised and examined a sandwich-like assay for detecting vitamin D3 dissolved in acetonitrile using fluorescent dye-embedded silica nanoparticles (AF647@SiNPs). First, AF647@SiNPs were synthesized via the modified Stöber method to embed the fluorescent dye molecules in the silicate network. Then, vitamin D3 (sample) was immobilized using an azide linker on the magnetic nanoparticles (MNPs). The immobilized vitamin D3 reacted with the antibody immobilized on the surface of AF647@SiNPs (Anti-VD3@AF647@SiNPs). The vitamin D3 concentration was calculated back using the fluorescence of the remaining unreacted Anti-VD3@AF647@SiNPs. Finally, we examined how applying conditions of AF647@SiNPs influenced the measurement reliability: (1) the initial loading of AF647@SiNPs; (2) the antibody-labeling degree of AF647@SiNPs. [ABSTRACT FROM AUTHOR]

Objective : The purpose of this study is to observe the effects of Dong-Qi acupuncture treatment for the patients with low back pain and sciatica. Methods : 60 patients were divided into two, Group A of 30 persons and Group B of 30 persons. Only Group A was treated with Dong-Qi acupuncture treatment, Group B was treated with just Dong-Si acupuncture treatment. Results : In VAS, Group A is 6.57±1.91 and Group B is 5.20±2.22(P=0.013). In Improvement index, Group A is 0.2295±0.1036 and Group B is 0.1545±0.0895 (P=0.004). Conclusion : We knew that Dong-Qi acupuncture treatment is more effective.

Objective : The purpose of this study is to report the patient with radial nerve palsy, who improved by oriental medical treatment. Methods : The patient was managed by Cathami Flos aqua-acupuncture, Dong-Qi acupuncture treatment, Comman acupuncture treatment and Herbal medicine. We took pictures of patient's wrist and checked the power of muscles. And we checked the numbness of thumb that was patient's subjective sensation. Results : After 2 weeks-treatment, the movement and power of wrist was restored to nearly normal range, also the numbness of thumb was removed. Combined oriental medical treatment can treat radial nerve palsy earlier than the other methods. Conclusions : The results suggest that combination of Cathami Flos aqua-acupuncture, Dong-Qi acupuncture treatment, Comman acupuncture treatment and Herbal medicine is good method for treatments of radial nerve palsy. But further studies are required to concretely prove the effectiveness of this method for treating radial nerve palsy.