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2,663 results on '"Lee, Jae‐Wook"'

153. Carbon-Neutralized Direct Methanol Fuel Cell Using Bifunctional (Methanol Oxidation/CO2 Reduction) Electrodes.

Author

Kim, Yong Seok, Lee, Jae Wook, Kim, Byeongkyu, Bae, Jong Wook, and Chung, Chan-Hwa

Subjects
*OXIDATION of methanol, *DIRECT methanol fuel cells, *METHANOL as fuel, *METHANOL, *OXYGEN electrodes, *ELECTRODES, *POWER density, *OXYGEN reduction
Abstract

In this study, a carbon-neutralized direct methanol fuel cell (DMFC) using two bifunctional electrodes, Pd-Ag and Pt-Zn, has been designed. This system has two modes, which are fuel-cell mode and spontaneous CO2 reduction mode. In the operation of fuel-cell mode, the methanol has been oxidized into CO2 on the Pd-Ag electrode and generates electricity. In the next step of the operation, CO2, which is the product of fuel-cell mode, has been spontaneously reduced to CO on Pd-Ag, and electricity has been obtained. In contrast, the Pt in the Pt-Zn electrode catalyzes the oxygen reduction reaction in the fuel-cell mode, and the Zn in Pt-Zn is oxidized sacrificially in the CO2 reduction mode. During operation in the fuel-cell mode, a power density of 12.11 mW/cm2 has been obtained with the production of CO2. On the other hand, the power density out of the CO2 reduction mode has been 11.76 mW/cm2. In each mode, the faradaic efficiencies of CO2 and CO have been 98.81% and 89.11%, respectively. [ABSTRACT FROM AUTHOR]

Published
2023
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154. Synthesis and Biological Properties of Pyranocoumarin Derivatives as Potent Anti-Inflammatory Agents.

Author

Min, Su Ji, Lee, Heesu, Shin, Myoung-Sook, and Lee, Jae Wook

Subjects
BIOSYNTHESIS, ANTI-inflammatory agents, TUMOR necrosis factors, NF-kappa B, NITRIC-oxide synthases, COUMARIN derivatives, MITOGEN-activated protein kinases
Abstract

This study aimed to synthesize 23 coumarin derivatives and analyze their anti-inflammatory effects on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 macrophages. A cytotoxicity test performed on LPS-induced RAW264.7 macrophages revealed that none of the 23 coumarin derivatives were cytotoxic. Among the 23 coumarin derivatives, coumarin derivative 2 showed the highest anti-inflammatory activity by significantly reducing nitric oxide production in a concentration-dependent manner. Coumarin derivative 2 inhibited the production of proinflammatory cytokines, including tumor necrosis factor alpha and interleukin-6, and decreased the expression level of each mRNA. In addition, it inhibited the phosphorylation of extracellular signal-regulated kinase, p38, c-Jun NH2-terminal kinase, nuclear factor kappa-B p65 (NF-κB p65), and inducible nitric oxide synthase. These results indicated that coumarin derivative 2 inhibited LPS-induced mitogen-activated protein kinase and NF-κB p65 signal transduction pathways in RAW264.7 cells, as well as proinflammatory cytokines and enzymes related to inflammatory responses, to exert anti-inflammatory effects. Coumarin derivative 2 showed potential for further development as an anti-inflammatory drug for the treatment of acute and chronic inflammatory diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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155. Curcumin hampers the antitumor effect of vinblastine via the inhibition of microtubule dynamics and mitochondrial membrane potential in HeLa cervical cancer cells

Author

Lee, Jae-Wook, Park, Sojin, Kim, Sun Yeou, Um, Sung Hee, and Moon, Eun-Yi

Subjects
Turmeric -- Health aspects -- Research, Medicine, Botanic -- Health aspects -- Research, Cervical cancer -- Care and treatment -- Research, Apoptosis -- Research, Medicine, Herbal -- Health aspects -- Research, Biological sciences, Health, Science and technology
Abstract

ABSTRACT Background: Curcumin, a major component of curry powder, which is a natural polyphenol product extracted from rhizoma curcumae longae, interacts with a specific binding site on microtubules. Vinblastine is [...]

Published
2016
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191. Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean patients

Author

Park, Meerim, Lee, Young Ho, Lee, Soo Hyun, Yoo, Keon Hee, Sung, Ki Woong, Koo, Hong Hoe, Lee, Ji Won, Kang, Hyoung Jin, Park, Kyung Duk, Shin, Hee Young, Ahn, Hyo Seop, Lee, Jae Wook, Chung, Nack-Gyun, Cho, Bin, Kim, Hack-Ki, Koh, Kyung-Nam, Im, Ho Joon, Seo, Jong Jin, Baek, Hee Jo, Kook, Hoon, Hwang, Tai Ju, Lee, Jae Min, Hah, Jeong Ok, Lim, Yeon Jung, Park, Jun Eun, Lyu, Chuhl Joo, Lim, Young Tak, Chong, So Young, and Oh, Doyeun

Published
2015
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