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3,369 results on '"Lee, Hyun Jung"'

160. Differing Efficacy of Dapagliflozin Versus Empagliflozin on the Risk of Incident Atrial Fibrillation in Patients With Type 2 Diabetes: A Real‐World Observation Using a Nationwide, Population‐Based Cohort

Author

Lim, Jaehyun, primary, Kwak, Soongu, additional, Choi, You‐Jung, additional, Rhee, Tae‐Min, additional, Park, Chan Soon, additional, Kim, Bongseong, additional, Han, Kyung‐Do, additional, Lee, Heesun, additional, Park, Jun‐Bean, additional, Kim, Yong‐Jin, additional, Lee, Hyun‐Jung, additional, and Kim, Hyung‐Kwan, additional

Published
2024
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165. Mitral Annular Tissue Velocity Predicts Survival in Patients With Primary Mitral Regurgitation

Author

Choi, You-Jung, primary, Park, Chan Soon, additional, Rhee, Tae-Min, additional, Lee, Hyun-Jung, additional, Choi, Hong-Mi, additional, Hwang, In-Chang, additional, Park, Jun-Bean, additional, Yoon, Yeonyee E., additional, Na, Jin Oh, additional, Kim, Hyung-Kwan, additional, Kim, Yong-Jin, additional, Cho, Goo-Yeong, additional, Sohn, Dae-Won, additional, and Lee, Seung-Pyo, additional

Published
2024
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166. Mildly Reduced Renal Function Is Associated With Increased Heart Failure Admissions in Patients With Hypertrophic Cardiomyopathy

Author

Bae, Nan Young, primary, Rhee, Tae-Min, additional, Park, Chan Soon, additional, Choi, You-Jung, additional, Lee, Hyun-Jung, additional, Choi, Hong-Mi, additional, Park, Jun-Bean, additional, Yoon, Yeonyee E., additional, Kim, Yong-Jin, additional, Cho, Goo-Yeong, additional, Hwang, In-Chang, additional, and Kim, Hyung-Kwan, additional

Published
2024
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167. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time

Author

Seo, Daeha, Southard, Kaden M, Kim, Ji-wook, Lee, Hyun Jung, Farlow, Justin, Lee, Jung-uk, Litt, David B, Haas, Thomas, Alivisatos, A Paul, Cheon, Jinwoo, Gartner, Zev J, and Jun, Young-wook

Subjects
Biochemistry and Cell Biology, Biological Sciences, Bioengineering, Nanotechnology, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Actins, Cadherins, Cell Line, Cells, Cultured, Genetic Techniques, Humans, Mechanoreceptors, Mechanotransduction, Cellular, Metal Nanoparticles, Microspheres, Molecular Probe Techniques, Receptors, Notch, Recombinant Fusion Proteins, Spatial Analysis, Time, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Tools capable of imaging and perturbing mechanical signaling pathways with fine spatiotemporal resolution have been elusive, despite their importance in diverse cellular processes. The challenge in developing a mechanogenetic toolkit (i.e., selective and quantitative activation of genetically encoded mechanoreceptors) stems from the fact that many mechanically activated processes are localized in space and time yet additionally require mechanical loading to become activated. To address this challenge, we synthesized magnetoplasmonic nanoparticles that can image, localize, and mechanically load targeted proteins with high spatiotemporal resolution. We demonstrate their utility by investigating the cell-surface activation of two mechanoreceptors: Notch and E-cadherin. By measuring cellular responses to a spectrum of spatial, chemical, temporal, and mechanical inputs at the single-molecule and single-cell levels, we reveal how spatial segregation and mechanical force cooperate to direct receptor activation dynamics. This generalizable technique can be used to control and understand diverse mechanosensitive processes in cell signaling. VIDEO ABSTRACT.

Published
2016

191. Cross-Recommendation Depending on Commonly Shared Users’ Preferences in IoT Environment

Author

Lee, Hyun Jung, Sohn, Mye, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio S., Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Barolli, Leonard, editor, and Enokido, Tomoya, editor

Published
2018
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192. Ontology Development for Dynamic Service Composition in Cyber-Physical Systems (CPSs)

Author

Jeong, Sunghwan, Kong, Jun-Sik, Sohn, Mye, Lee, Hyun Jung, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio S., Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Barolli, Leonard, editor, and Enokido, Tomoya, editor

Published
2018
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