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928 results on '"Lee, Dong-Hyeon"'

155. Surgical Outcomes of Transvaginal Neobladder-Vaginal Fistula Repair After Radical Cystectomy with Ileal Orthotopic Neobladder: A Case–Control Study [Erratum]

Author

Lee,Dong Hyeon and Song,Wan

Subjects
Cancer Management and Research
Abstract

Lee DH, Song W. Cancer Manag Res. 2020;12:10279–10286. The authors have advised that the Funding statement wasmissed on page 10285 of the published paper. This errorwas introduced by the Editorial staff during the publicationprocess. The funding statement should read as follows:FundingThis research was supported by the Basic Science ResearchProgram through a National Research Foundation of Koreagrant funded by the Ministry of Science, ICT & FuturePlanning (NRF-2018R1C1B6007678) Read the original article

Published
2020

156. Prognostic Value of Programmed Death Ligand-1 Expression on Tumor-Infiltrating Immune Cells in Patients Treated with Cisplatin-Based Combination Adjuvant Chemotherapy Following Radical Cystectomy for Muscle-Invasive Bladder Cancer: A Retrospective Cohort Study

Author

Lee,Dong Hyeon, Jeong,Jae Yong, Song,Wan, Lee,Dong Hyeon, Jeong,Jae Yong, and Song,Wan

Abstract

Dong Hyeon Lee,1 Jae Yong Jeong,2 Wan Song3 1Department of Urology, Ewha Womans University Medical Center, Ewha Womans University School of Medicine, Seoul, Korea; 2Department of Urology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea; 3Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaCorrespondence: Wan SongDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 135-710, KoreaTel +82-2-3410-3558Fax +82-2-3410-3027Email wan.song@samsung.comPurpose: To investigate the prognostic value of programmed death ligand-1 (PD-L1) expression in tumor-infiltrating immune cells (ICs) in men treated with adjuvant chemotherapy (AC) following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC).Materials and Methods: We retrospectively reviewed 219 “high-risk” (≥pT3a and/or pN+) patients who underwent RC and received cisplatin-based AC for MIBC between March 2015 and September 2019. PD-L1 expression was measured using the VENTANA (SP-142) immunohistochemistry assay and categorized into the three groups according to the percentage of the tumor area covered by PD-L1 expression on ICs: IC0 (< 1%), IC1 (≥ 1% and < 5%), and IC2/3 (≥ 5%). Positive PD-L1 expression was defined as IC2/3 (≥ 5%). Kaplan–Meier survival analysis was used to assess recurrence-free survival (RFS), and Cox proportional hazard models were applied to identify factors predicting tumor recurrence.Results: In the entire cohort, the overall prevalence of PD-L1 IC0, IC1, and IC2/3 was 13.2%, 27.4%, and 59.4%, respectively. During the mean follow-up of 32.5 months, tumor recurrence was detected in 115 (52.5%) patients. On multivariable analysis, tumor stage (≥pT3; P=0.032), positive lymph nodes (P=0.001), and positive PD-L1 on ICs (P=0.005) were independent predictors of tumor

Published
2021

174. Hepatocellular Carcinoma in Korea between 2012 and 2014: an Analysis of Data from the Korean Nationwide Cancer Registry

Author

Chon, Young Eun, primary, Lee, Han Ah, additional, Yoon, Jun Sik, additional, Park, Jun Yong, additional, Kim, Bo Hyun, additional, Lee, In Joon, additional, Hong, Suk Kyun, additional, Lee, Dong Hyeon, additional, Kong, Hyun-Joo, additional, Kim, Eunyang, additional, Won, Young-Joo, additional, and Lee, Jeong-Hoon, additional

Published
2020
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176. Circulating lipidomic alterations in obese and non-obese subjects with non-alcoholic fatty liver disease

Author

Jung, Youngae, primary, Lee, Min Kyung, additional, Puri, Puneet, additional, Koo, Bo Kyung, additional, Joo, Sae Kyung, additional, Jang, Seo Young, additional, Lee, Dong Hyeon, additional, Jung, Yong Jin, additional, Kim, Byeong Gwan, additional, Lee, Kook Lae, additional, Park, Tae-Sik, additional, Kang, Ki-Tae, additional, Ryu, Do Hyun, additional, Kang, Sang Won, additional, Kim, Donghee, additional, Oh, Sohee, additional, Kim, Won, additional, and Hwang, Geum-Sook, additional

Published
2020
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177. Management of Patients With Advanced Prostate Cancer: Establishment of Treatment Guidelines Through Prostate Cancer Summit (PCAS) 2016 Composed of Korean Prostate Cancer Experts

Author

Jang, Chun Tae, primary, Kim, Hyung Joon, additional, Kim, Myung Ki, additional, Park, Sung Woo, additional, Park, Seung Chol, additional, Park, Jae Young, additional, Lee, Dong Hyeon, additional, Lee, Seung Hwan, additional, Jeon, Hwang Gyun, additional, Chung, Jae Hoon, additional, Jeong, Hyeon, additional, Jo, Moon Ki, additional, Hong, Sung-Hoo, additional, Kwak, Cheol, additional, Lee, Ji Youl, additional, Kwon, Dong Deuk, additional, Kim, Choung-Soo, additional, and Jeon, Seong Soo, additional

Published
2020
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189. A sequential approach using the age‐adjusted fibrosis‐4 index and vibration‐controlled transient elastography to detect advanced fibrosis in Korean patients with non‐alcoholic fatty liver disease.

Author

Lee, Dong Hyeon, Sung, Se Un, Lee, Yun Kyu, Lim, Ik Hyeon, Jang, Heejoon, Joo, Sae Kyoung, Park, Jeong Hwan, Chang, Mee Soo, So, Young Ho, and Kim, Won

Subjects
*NON-alcoholic fatty liver disease, *KOREANS, *FIBROSIS, *ELASTOGRAPHY, *LIVER biopsy
Abstract

Summary: Background and Aims: Vibration‐controlled transient elastography (VCTE) has shown good diagnostic performance in predicting fibrosis stages in patients with non‐alcoholic fatty liver disease (NAFLD). However, an optimal diagnostic approach to detect advanced fibrosis in patients with NAFLD has not been established. Approach and Results: We prospectively collected data from 539 subjects who underwent liver biopsy at a single centre between January 2014 and December 2019. Diagnostic performance was estimated using the area under the receiver‐operating characteristic curve (AUROC). Several models combining the fibrosis 4 index (FIB‐4) score and liver stiffness measurement (LSM) were analysed to reduce the need for unnecessary liver biopsies. We observed significant fibrosis (≥F2), advanced fibrosis (≥F3) and cirrhosis (F4) in 173 (32.1%), 74 (13.7%) and 46 subjects (8.5%), respectively. The AUROCs (95% CI) for LSMs to diagnose ≥F2, ≥F3 and F4 were 0.82 (0.78‐0.85), 0.92 (0.89‐0.94) and 0.95 (0.93‐0.97), respectively. Optimal LSM cut‐off values were 6.7 (≥F2), 8.3 (≥F3) and 9.8 (F4) kPa. LSMs were affected by waist circumference, serum albumin and fibrosis stage (R2 = 0.315). Abdominal obesity, elevated transaminase, diabetes mellitus and high IQR/Median were associated with the discordance of ≥2 fibrosis stages between LSMs and histologic data. The sequential use of the age‐adjusted FIB‐4 and LSMs yielded the least uncertainty (5.3%) in classifying disease severity with the highest diagnostic accuracy (81%) among a variety of non‐invasive test combinations. Conclusions: The sequential approach of age‐adjusted FIB‐4 and VCTE could represent a practical diagnostic strategy to detect advanced fibrosis in NAFLD (ClinicalTrials.gov #NCT 02206841). [ABSTRACT FROM AUTHOR]

Published
2022
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190. Association between circulating bile acid alterations and nonalcoholic steatohepatitis independent of obesity and diabetes mellitus.

Author

Jung, Youngae, Koo, Bo Kyung, Jang, Seo Young, Kim, Dain, Lee, Heeyeon, Lee, Dong Hyeon, Joo, Sae Kyung, Jung, Yong Jin, Park, Jeong Hwan, Yoo, Taekyeong, Choi, Murim, Lee, Min Kyung, Kang, Sang Won, Chang, Mee Soo, Kim, Won, and Hwang, Geum‐Sook

Subjects
NON-alcoholic fatty liver disease, FATTY liver, BILE acids, DIABETES, METABOLIC disorders
Abstract

Background and Aims: Bile acid (BA) dysregulation is related to not only metabolic diseases but also nonalcoholic fatty liver disease (NAFLD). We investigated whether circulating BA levels are altered according to the histological severity of NAFLD independent of metabolic derangements. Methods: Global metabolic profiling and targeted BA analysis using sera collected from biopsy‐proven no‐NAFLD (n = 67), nonalcoholic fatty liver (NAFL) (n = 99), and nonalcoholic steatohepatitis (NASH, n = 75) subjects were performed sequentially. Circulating metabolome analysis integrated with the hepatic transcriptome was performed to elucidate the mechanistic basis of altered circulating BA profiles after stratification by obesity (body mass index ≤ 25 kg/m2). Circulating BA alterations were also validated in an independent validation cohort (29 no‐NAFLD, 70 NAFL and 37 NASH). Results: Global profiling analysis showed that BA was the metabolite significantly altered in NASH compared to NAFL. Targeted BA analysis demonstrated that glyco‐/tauro‐conjugated primary BAs were commonly increased in nonobese and obese NASH, while unconjugated primary BAs increased only in nonobese NASH. These characteristic primary BA level changes were maintained even after stratification according to diabetes status and were replicated in the independent validation cohort. Compared to nonobese NAFL patients, nonobese NASH patients exhibited upregulated hepatic expression of CYP8B1. Conclusions: BA metabolism is dysregulated as the histological severity of NAFLD worsens, independent of obesity and diabetes status; dysregulation is more prominent in nonobese NAFLD patients. Metabolome‐driven omics approach provides new insight into our understanding of altered BA metabolism associated with individual phenotypes of NAFLD. [ABSTRACT FROM AUTHOR]

Published
2021
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192. Mitrula aureasp. nov., A New Aero-Aquatic Species from the Republic of Korea

Author

Cho, Sung-Eun, Kim, Hyung So, Kwag, Young-Nam, Lee, Dong-Hyeon, Han, Jae-Gu, and Kim, Chang Sun

Abstract

AbstractThe genus Mitrula(Mitrulaceae, Helotiales), as also known as swamp beacons, inhabits submerged, decaying vegetation in standing or decaying needles, twigs, leaves, and shallow water. They play an important role in carbon cycling in some freshwater ecosystems. In the herbarium of the Korea National Arboretum (KH), seven Mitrulaspecimens were collected during mushroom forays in the period from 2019 to 2021. The Korean collections were found to be macromorphologically closely related to M. paludosaand M. elegans, but micromorphologically they could be distinguished by characteristics of slightly narrower asci and aseptate ascospores. Our molecular phylogenetic analyses of the internal transcribed spacer (ITS) and 28S rDNA regions also revealed that our specimens were related to M. paludosaand M. elegans, but formed a distinct clade. Based on these results, we reported our specimens as new to science and discussed the phylogeny and diversity of Mitrulaspecies.

Published
2022
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194. IL-15 Enhances CCR5-Mediated Migration of Memory CD8+ T Cells by Upregulating CCR5 Expression in the Absence of TCR Stimulation

Author

Seo, In-Ho, primary, Eun, Hyuk Soo, additional, Kim, Ja Kyung, additional, Lee, Hoyoung, additional, Jeong, Seongju, additional, Choi, Seong Jin, additional, Lee, Jeewon, additional, Lee, Byung Seok, additional, Kim, Seok Hyun, additional, Rou, Woo Sun, additional, Lee, Dong Hyeon, additional, Kim, Won, additional, Park, Su-Hyung, additional, and Shin, Eui-Cheol, additional

Published
2020
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199. Nonalcoholic steatohepatitis is associated with a higher risk of advanced colorectal neoplasm

Author

Cho, Yuri, primary, Lim, Soo‐Kyung, additional, Joo, Sae Kyung, additional, Jeong, Dong‐Hyong, additional, Kim, Jung Ho, additional, Bae, Jeong Mo, additional, Park, Jeong Hwan, additional, Chang, Mee Soo, additional, Lee, Dong Hyeon, additional, Jung, Yong Jin, additional, Kim, Byeong Gwan, additional, Kim, Donghee, additional, Lee, Kook Lae, additional, and Kim, Won, additional

Published
2019
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