151. [Hemoglobin SD disease].
- Author
-
Laws HJ, Dickerhoff R, Mayer J, and Köster B
- Subjects
- Anemia, Sickle Cell diagnosis, Anemia, Sickle Cell genetics, Brain pathology, Cerebral Infarction diagnosis, Cerebral Infarction genetics, Child, Diagnosis, Differential, Female, Hemoglobin SC Disease diagnosis, Humans, Magnetic Resonance Imaging, Thalassemia diagnosis, Genetic Carrier Screening, Hemoglobin SC Disease genetics, Hemoglobin, Sickle genetics, Hemoglobins, Abnormal genetics, Thalassemia genetics
- Abstract
A 7 year old Kurdish girl presented with a cerebral infarction and a resulting hemiparesis following a blood transfusion. Examination of the blood film suggested sickle cell anaemia. However a simultaneously carried out haemoglobin electrophoresis showed haemoglobin S and haemoglobin D. The diagnosis of haemoglobin SD disease was thereby established. This kind of haemoglobin disorder usually shows a mild clinical manifestation. According to our knowledge such serious cases have not been published before. With this disease the main emphasis is on the prevention of recurrent cerebral infarctions bay a long-term transfusion programme whereas the effects of the cerebral infarction are treated in the usual way.
- Published
- 1993