2,439 results on '"Lauten, A"'
Search Results
152. Oral Health in the Population Assessment of Tobacco and Health Study
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B.W. Chaffee, K. Lauten, E. Sharma, C.D. Everard, K. Duffy, E. Park-Lee, E. Taylor, E. Tolliver, T. Watkins-Bryant, T. Iafolla, W.M. Compton, H.L. Kimmel, A. Hyland, and M.L. Silveira
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Adult ,stomatognathic diseases ,Cross-Sectional Studies ,Tobacco ,Humans ,Oral Health ,Electronic Nicotine Delivery Systems ,Nutrition Surveys ,General Dentistry ,United States - Abstract
Tobacco use is a well-established risk factor for multiple adverse oral conditions. Few nationally representative oral health data sets encompass the current diversity of tobacco and nicotine products. This investigation examines the validity of oral health measures in the Population Assessment of Tobacco and Health (PATH) Study to assess relationships between tobacco use and oral health. Cross-sectional data from PATH Study wave 4 ( N = 33,643 US adults, collected 2016–2018) were used to obtain estimates for 6 self-reported oral conditions (e.g., bone loss around teeth, tooth extractions) and compared with analogous estimates from the National Health and Nutrition Examination Survey (NHANES) cycle 2017–2018 ( N = 5,856). Within the PATH Study, associations were calculated between tobacco use status and lifetime and past 12-mo experience of adverse oral conditions using survey-weighted multivariable logistic regression. Nationally representative estimates of oral conditions between the PATH Study and NHANES were similar (e.g., ever-experience of bone loss around teeth: PATH Study 15.2%, 95% CI, 14.4%–15.9%; NHANES 16.6%, 95% CI, 14.9%–18.4%). In the PATH Study, combustible tobacco smoking was consistently associated with lifetime and past 12-mo experience of adverse oral health (e.g., exclusive cigarette smoking vs. never tobacco use, adjusted odds ratio [AOR] for loose teeth in past 12 mo: 2.02; 95% CI, 1.52–2.69). Exclusive smokeless tobacco use was associated with greater odds of loose teeth (AOR, 1.93; 95% CI, 1.15–3.26) and lifetime precancerous lesions (AOR, 3.85; 95% CI, 1.73–8.57). Use of other noncigarette products (e.g., pipes) was inconsistently associated with oral health outcomes. PATH Study oral health measures closely align with self-reported measures from NHANES and are internally concurrent. Observed associations with tobacco use and the ability to examine emerging tobacco products support application of PATH Study data in dental research, particularly to examine potential oral health effects of novel tobacco products and longitudinal changes in tobacco use behaviors.
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- 2023
153. Early hydration of C3A–gypsum pastes with Ca- and Na-lignosulfonate
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Danner, Tobias, Justnes, Harald, Geiker, Mette, and Lauten, Rolf Andreas
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- 2016
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154. Selenoprotein P in Myocardial Infarction With Cardiogenic Shock
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Büttner, Petra, Obradovic, Danilo, Wunderlich, Sebastian, Feistritzer, Hans-Josef, Holzwirth, Erik, Lauten, Philipp, Fuernau, Georg, de Waha-Thiele, Suzanne, Desch, Steffen, and Thiele, Holger
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- 2020
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155. Trikuspidalklappenstenose
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Stähli, Barbara Elisabeth, primary and Lauten, Alexander, additional
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- 2018
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156. Impella Support for Acute Myocardial Infarction Complicated by Cardiogenic Shock: Matched-Pair IABP-SHOCK II Trial 30-Day Mortality Analysis
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Schrage, Benedikt, Ibrahim, Karim, Loehn, Tobias, Werner, Nikos, Sinning, Jan-Malte, Pappalardo, Federico, Pieri, Marina, Skurk, Carsten, Lauten, Alexander, Landmesser, Ulf, Westenfeld, Ralf, Horn, Patrick, Pauschinger, Matthias, Eckner, Dennis, Twerenbold, Raphael, Nordbeck, Peter, Salinger, Tim, Abel, Peter, Empen, Klaus, Busch, Mathias C., Felix, Stephan B., Sieweke, Jan-Thorben, Møller, Jacob Eifer, Pareek, Nilesh, Hill, Jonathan, MacCarthy, Philip, Bergmann, Martin W., Henriques, José P.S., Möbius-Winkler, Sven, Schulze, P. Christian, Ouarrak, Taoufik, Zeymer, Uwe, Schneider, Steffen, Blankenberg, Stefan, Thiele, Holger, Schäfer, Andreas, and Westermann, Dirk
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- 2019
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157. Neuropeptide Y potentiates T-Lymphocyte inflammation after psychological trauma
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Lauten, Tatlock, primary, Reed, Emily, additional, Elkhatib, Safwan, additional, Moshfegh, Cassandra, additional, Clopp, Amelia, additional, and Case, Adam, additional
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- 2023
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158. Antimicrobial use in pediatric oncology and hematology in Germany and Austria, 2020/2021: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process
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Papan, Cihan, primary, Reifenrath, Katharina, additional, Last, Katharina, additional, Attarbaschi, Andishe, additional, Graf, Norbert, additional, Groll, Andreas H., additional, Hübner, Johannes, additional, Laws, Hans-Jürgen, additional, Lehrnbecher, Thomas, additional, Liese, Johannes G., additional, Martin, Luise, additional, Tenenbaum, Tobias, additional, Vieth, Simon, additional, von Both, Ulrich, additional, Wagenpfeil, Gudrun, additional, Weichert, Stefan, additional, Hufnagel, Markus, additional, Simon, Arne, additional, Baier, Jan, additional, Balzer, Stefan, additional, Behr, Ümmügül, additional, Bernbeck, Benedikt, additional, Beutel, Karin, additional, Blattmann, Claudia, additional, Bochennek, Konrad, additional, Cario, Holger, additional, Eggert, Angelika, additional, Ehlert, Karoline, additional, Göpner, Simone, additional, Kontny, Udo, additional, Körholz, Dieter, additional, Kramm, Christof, additional, Lauten, Melchior, additional, Lessel, Lienhard, additional, Linderkamp, Christin, additional, Lobitz, Stephan, additional, Maas, Volker, additional, Misgeld, Rainer, additional, Mücke, Urs, additional, Neubert, Jennifer, additional, Nonnenmacher, Lisa, additional, Queudeville, Manon, additional, Redlich, Antje, additional, Rodehüser, Martina, additional, Schober, Sarah, additional, Siepermann, Meinolf, additional, Simon, Thorsten, additional, Souliman, Hadi, additional, Stiefel, Martina, additional, Wiegering, Verena, additional, and Winkler, Beate, additional
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- 2023
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159. Influence of Culprit Lesion Intervention on Outcomes in Infarct-Related Cardiogenic Shock With Cardiac Arrest
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Zeymer, Uwe, primary, Alushi, Brunilda, additional, Noc, Marko, additional, Mamas, Mamas A., additional, Montalescot, Gilles, additional, Fuernau, Georg, additional, Huber, Kurt, additional, Poess, Janine, additional, de Waha-Thiele, Suzanne, additional, Schneider, Steffen, additional, Ouarrak, Taoufik, additional, Desch, Steffen, additional, Lauten, Alexander, additional, and Thiele, Holger, additional
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- 2023
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160. Measurements of production cross sections of 10Be and 26Al by 120 GeV and 392 MeV proton bombardment of 89Y, 159Tb, and natCu targets
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Sekimoto, S., Okumura, S., Yashima, H., Matsushi, Y., Matsuzaki, H., Matsumura, H., Toyoda, A., Oishi, K., Matsuda, N., Kasugai, Y., Sakamoto, Y., Nakashima, H., Boehnlein, D., Coleman, R., Lauten, G., Leveling, A., Mokhov, N., Ramberg, E., Soha, A., Vaziri, K., Ninomiya, K., Omoto, T., Shima, T., Takahashi, N., Shinohara, A., Caffee, M.W., Welten, K.C., Nishiizumi, K., Shibata, S., and Ohtsuki, T.
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- 2015
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161. Electrochemistry aspects of pyrite in the presence of potassium amyl xanthate and a lignosulfonate-based biopolymer depressant
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Mu, Yufan, Peng, Yongjun, and Lauten, Rolf Andreas
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- 2015
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162. Phase changes during the early hydration of Portland cement with Ca-lignosulfonates
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Danner, Tobias, Justnes, Harald, Geiker, Mette, and Lauten, Rolf Andreas
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- 2015
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163. Inadequate Timing Limits the Benefit of Antenatal Corticosteroids on Neonatal Outcome: Retrospective Analysis of a High-Risk Cohort of Preterm Infants in a Tertiary Center in Germany
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Richard, Biedermann, Ekkehard, Schleussner, Angela, Lauten, Yvonne, Heimann, Thomas, Lehmann, Hans, Proquitté, and Friederike, Weschenfelder
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Maternity and Midwifery ,Obstetrics and Gynecology - Abstract
Introduction A common problem in the treatment of threatened preterm birth is the timing and the unrestricted use of antenatal corticosteroids (ACS). This study was performed to evaluate the independent effects of the distinct timing of antenatal corticosteroids on neonatal outcome parameters in a cohort of very low (VLBW; 1000 – 1500 g) and extreme low birth weight infants (ELBW; Materials and Methods Main data source was the prospectively collected single center data for the German nosocomial infection surveillance system (KISS) between 2015 and 2018. Multivariate regression analysis was performed to determine independent effects of the ACS-to-delivery interval on the need for ventilation, surfactant or the occurrence of bronchopulmonary dysplasia, neonatal sepsis or necrotizing enterocolitis. Subgroup analysis was performed for ELBW and VLBW neonates. Results A total of 239 neonates were included. We demonstrate a significantly increased risk of respiratory distress characterized by the need for ventilation (OR 1.045; CI 1.011 – 1.080) and surfactant administration (OR 1.050, CI 1.018 – 1.083) depending on the ACS-to-delivery interval irrespective of other confounders. Every additional day between ACS and delivery increased the risk for ventilation by 4.5% and for surfactant administration by 5%. Subgroup analysis revealed significant differences of respiratory complications in VLBW infants. Conclusions Our data strongly support the deliberate use and timing of antenatal corticosteroids in pregnancies with threatened preterm birth versus a liberal strategy. When given more than 7 days before birth, each day between application and delivery increases is relevant concerning major effects on the infant. Especially VLBW preterm neonates benefit from optimal timing.
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- 2022
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164. Neuropeptide Y potentiates T-Lymphocyte inflammation after psychological trauma
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Tatlock Lauten, Emily Reed, Safwan Elkhatib, Cassandra Moshfegh, Amelia Clopp, and Adam Case
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Physiology - Abstract
Post-traumatic stress disorder (PTSD) is a psychiatric disorder characterized by severe behavioral alterations, but also demonstrates elevated levels of systemic inflammation, sympathoexcitation, and a potentiated risk for autoimmune and cardiovascular diseases. These physiological changes suggest perturbations to the immune system, however, the signaling mechanisms linking psychological trauma to the immune system are not well understood. Utilizing a pre-clinical mouse model of PTSD known as repeated social defeat stress (RSDS), we previously demonstrated that psychological trauma causes robust T-lymphocyte-driven inflammation in the spleen as evidenced by increased pro-inflammatory cytokine production (primarily interleukin 17A, IL-17A), inflammatory polarization, and enhanced mitochondrial reactive oxygen species. Moreover, targeted denervation of the spleen was able to completely ablate this T-lymphocyte inflammatory response after psychological trauma, suggesting the signal was autonomic and neural in nature. Given that the splenic nerve possesses only sympathetic neurons (no direct parasympathetic innervation), we hypothesized that psychological trauma mediates splenic T-lymphocyte inflammation via enhanced release of sympathetic neurotransmitters. To test this, we first exposed naïve primary T-lymphocytes to various sympathetic catecholamines, including dopamine, norepinephrine, and epinephrine. Contrary to our original hypothesis, we observed no significant changes in IL-17A expression or mitochondria reactive oxygen species. Next, we assessed the physiological response of naïve T-lymphocytes exposed to neuropeptide Y (NPY) given its role in both sympathoexcitation as well as in PTSD. Interestingly, naïve T-lymphocytes treated with NPY also demonstrated no effect, but when NPY was given in combination of norepinephrine, we observed both an increase in IL-17A gene expression (~2 fold) and intracellular redox (~2 fold). To further investigate this effect, we examined NPY levels in our RSDS mouse model over-time. Circulating NPY levels spiked immediately after only one day of RSDS (~4.5 fold, p=0.0317) but steadily declined over the remaining 10 day psychological trauma induction. Intriguingly, NPY levels were strongly correlated with both circulating IL-17A and T-lymphocyte mitochondrial reactive oxygen species levels after RSDS, supporting our in vitro observations. Overall, these data suggest NPY may be playing a critical role in shaping the inflammatory milieu after psychological trauma, which may enhance the likelihood of inflammatory comorbidities. NIH R01HL158521 This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
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- 2023
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165. Patent foramen ovale closure for patients excluded from the randomized cryptogenic stroke trials: response to letter by Zaman et al.
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Alushi, Brunilda, Lauten, Alexander, Landmesser, Ulf, and Kastrati, Adnan
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- 2018
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166. Intravaskulärer Ultraschall in der Behandlung der koronaren Herzkrankheit: Technische und klinische Grundlagen
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Stähli, B. E., Riedel, M., Lauten, A., and Leistner, D. M.
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- 2017
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167. Microparticles in patients undergoing transcatheter aortic valve implantation (TAVI)
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Jung, Christian, Lichtenauer, Michael, Figulla, Hans-Reiner, Wernly, Bernhard, Goebel, Bjoern, Foerster, Martin, Edlinger, Christoph, and Lauten, Alexander
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- 2017
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168. Invasive Mold Infection of the Central Nervous System in Immunocompromised Children
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Luciana Porto, Se-Jong You, Andishe Attarbaschi, Gunnar Cario, Michaela Döring, Olga Moser, Urs Mücke, Fiona Poyer, Christian Temme, Sebastian Voigt, Andreas H. Groll, Melchior Lauten, Elke Hattingen, and Thomas Lehrnbecher
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child ,invasive mold infection ,central nervous system ,magnetic resonance imaging of the brain ,outcome ,Biology (General) ,QH301-705.5 - Abstract
Background: Due to the difficulties in the definite diagnosis, data on brain imaging in pediatric patients with central nervous system (CNS)-invasive mold infection (IMD) are scarce. Our aim was to describe brain imaging abnormalities seen in immunocompromised children with CNS-IMD, and to analyze retrospectively whether specific imaging findings and sequences have a prognostic value. Methods: In a retrospective study of 19 pediatric patients with proven or probable CNS-IMD, magnetic resonance imaging (MRI)-findings were described and analyzed. The results were correlated with outcome, namely death, severe sequelae, or no neurological sequelae. Results: 11 children and 8 adolescents (11/8 with proven/probable CNS-IMD) were included. Seven of the patients died and 12/19 children survived (63%): seven without major neurological sequelae and five with major neurological sequelae. Multifocal ring enhancement and diffusion restriction were the most common brain MRI changes. Diffusion restriction was mostly seen at the core of the lesion. No patient with disease limited to one lobe died. Perivascular microbleeding seen on susceptibility weighted imaging (SWI) and/or gradient-echo/T2* images, as well as infarction, were associated with poor prognosis. Conclusions: The presence of infarction was related to poor outcome. As early microbleeding seems to be associated with poor prognosis, we suggest including SWI in routine diagnostic evaluation of immunocompromised children with suspected CNS-IMD.
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- 2020
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169. Transcatheter Aortic Valve Replacement and Concomitant Mitral Regurgitation
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Barbara E. Stähli, Markus Reinthaler, David M. Leistner, Ulf Landmesser, and Alexander Lauten
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transcatheter aortic vave replacement ,mitral valve insufficiency ,mitral valve repair ,aortic stenosis ,aortic valve ,mitral valve ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Mitral regurgitation frequently coexists in patients with severe aortic stenosis. Patients with moderate to severe mitral regurgitation at the time of transcatheter aortic valve replacement are at increased risk of future adverse events. Whether concomitant mitral regurgitation is independently associated with worse outcomes after TAVR remains a matter of debate. The optimal therapeutic strategy in these patients—TAVR with evidence-based heart failure therapy, combined TAVR and transcatheter mitral valve intervention, or staged transcatheter therapies—is ill-defined, and guideline-based recommendations in patients at increased risk for open heart surgery are lacking. Hence, a thorough evaluation of the aortic and mitral valve anatomy and function, along with an in-depth assessment of the patients' baseline risk profile, provides the basis for an individualized treatment approach. The aim of this review is therefore to give an overview of the current literature on mitral regurgitation in TAVR, focusing on different diagnostic and therapeutic strategies and optimal clinical decision making.
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- 2018
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170. Tricuspid Regurgitation – Medical Management and Evolving Interventional Concepts
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Frederik Beckhoff, Brunilda Alushi, Christian Jung, Eliano Navarese, Marcus Franz, Daniel Kretzschmar, Bernhard Wernly, Michael Lichtenauer, and Alexander Lauten
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Tricuspid Valve Regurgitation ,Interventional Therapies ,The FORMA Device ,Trialign ,TriCinch ,Traipta ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Severe tricuspid regurgitation (TR) is a complex condition of the right ventricle (RV) and tricuspid valve apparatus and is frequently associated with symptomatic heart failure and a significant morbidity and mortality. In these patients, left heart pathologies lead to chronic pressure overload of the RV, eventually causing progressive RV dilatation and functional TR. Therefore, TR cannot be considered as isolated heart valve disease pathology but has to be understood and treated as one component of a complex structural RV pathology and is frequently also a marker of an advanced stage of cardiac disease. In these patients, medical therapy restricted to diuretics and heart failure medication is frequently ineffective. Also, severe TR in the setting of advanced heart failure constitutes a high risk for cardiac surgery. Neither one of these treatment options has demonstrated a beneficial effect on long-term prognosis. The recent innovations in transcatheter technology led to efforts to develop interventional approaches to severe TR. Multiple innovative treatment concepts are currently under preclinical and clinical investigation to replace or repair TV function. However, up to date none of these approaches is established and there is still a lack of clinical data to support the efficacy of transcatheter TR treatment.
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- 2018
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171. Hämatologie
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Niemeyer, C. M., Lauten, M., Nowak-Göttl, U., Krümpel, A., Knöfler, R., Speer, Christian P., editor, and Gahr, Manfred, editor
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- 2013
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172. Erratum zu: DKG-Zertifizierung kinderonkologischer Zentren – ein weites Feld …
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Lauten, Melchior, Kontny, Udo, Nathrath, Michaela, and Schrappe, Martin
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- 2021
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173. Instrumentaldidaktikk Mesterlaerens dilemma -ekspertutøver og ekspertdidaktiker på samme tid?
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Lauten, Ingrid
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- 2023
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174. New Cerebral Microbleeds After Catheter‐Based Structural Heart Interventions: An Exploratory Analysis
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Braemswig, Tim Bastian, primary, Kusserow, Madeleine, additional, Bellmann, Barbara, additional, Beckhoff, Frederik, additional, Reinthaler, Markus, additional, von Rennenberg, Regina, additional, Erdur, Hebun, additional, Scheitz, Jan F., additional, Galinovic, Ivana, additional, Villringer, Kersten, additional, Leistner, David M., additional, Audebert, Heinrich J., additional, Endres, Matthias, additional, Landmesser, Ulf, additional, Haeusler, Karl Georg, additional, Fiebach, Jochen B., additional, Lauten, Alexander, additional, Rillig, Andreas, additional, and Nolte, Christian H., additional
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- 2023
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175. The first taxonomic and functional characterization of human CAVD-associated microbiota
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Curini, Lavinia, primary, Alushi, Brunilda, additional, Christopher, Mary Roxana, additional, Baldi, Simone, additional, Di Gloria, Leandro, additional, Stefano, Pierluigi, additional, Laganà, Anna, additional, Iannone, Luisa, additional, Grubitzsch, Herko, additional, Landmesser, Ulf, additional, Ramazzotti, Matteo, additional, Niccolai, Elena, additional, Lauten, Alexander, additional, and Amedei, Amedeo, additional
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- 2023
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176. CRT-700.59 Infective Endocarditis: Local Antibiotic Treatment, a Future Option for Transcatheter Valve Replacement?
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Seidel, Raphael A., primary, Lauten, Alexander, additional, Weberling, Anke, additional, Lange, Antonia, additional, and Figulla, Hans R., additional
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- 2023
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177. Association between tobacco product use and asthma among US adults from the Population Assessment of Tobacco and Health (PATH) Study waves 2–4
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Brunette, Mary F, primary, Halenar, Michael J, additional, Edwards, Kathryn C, additional, Taylor, Kristie A, additional, Emond, Jennifer A, additional, Tanski, Susanne E, additional, Woloshin, Steven, additional, Paulin, Laura M, additional, Hyland, Andrew, additional, Lauten, Kristen, additional, Mahoney, Martin, additional, Blanco, Carlos, additional, Borek, Nicolette, additional, DaSilva, Louis Claudio, additional, Gardner, Lisa D, additional, Kimmel, Heather L, additional, and Sargent, James D, additional
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- 2023
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178. Impact of TTVR on reverse remodeling of right-ventricular function and morphology in patients with severe tricuspid regurgitation – a CMRI pilot study
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Primet, Y., primary, Menck, N., additional, Alushi, B., additional, Bisht, O., additional, Löser, S., additional, Duddek, C., additional, Geweiler, J., additional, Alsheri, S., additional, Vathie, K., additional, Beuster, S., additional, Steinborn, F., additional, Mattea, V., additional, Schade, A., additional, Schulz-Menger, J., additional, and Lauten, A., additional
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- 2023
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179. Prognostic value of pre-interventional cerebral oxygen saturation in transcatheter aortic valve replacement: a prespecified secondary analysis of the SOLVE–TAVI trial
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Matthias Heringlake, Astrid E. Berggreen, Romina Baumgärtel, Thomas Kurz, Ursula Vigelius-Rauch, Sascha Treskatsch, Jörg Ender, Suzanne de Waha-Thiele, Steffen Desch, Holger Thiele, Hans-Josef Feistritzer, Georg Stachel, Philipp Hartung, Philipp Lurz, Ingo Eitel, Christoph Marquetand, Holger Nef, Oliver Doerr, Alexander Lauten, Ulf Landmesser, Mohamed Abdel-Wahab, Marcus Sandri, David Holzhey, Michael Borger, Hüseyin Ince, Alper Öner, Roza Meyer-Saraei, Rainer Hambrecht, Andreas Fach, Thomas Augenstein, Norbert Frey, Inke R. König, Reinhard Vonthein, Yvonne Rückert, and Anne-Kathrin Funkat
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Heart Valve Prosthesis Implantation ,Transcatheter Aortic Valve Replacement ,Treatment Outcome ,Anesthesiology and Pain Medicine ,Oxygen Saturation ,Risk Factors ,Aortic Valve ,Humans ,Aortic Valve Stenosis ,Prognosis - Published
- 2022
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180. Tobacco Use and Incidence of Adverse Oral Health Outcomes Among US Adults in the Population Assessment of Tobacco and Health Study
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Silveira, Marushka L., primary, Everard, Colm D., additional, Sharma, Eva, additional, Lauten, Kristin, additional, Alexandridis, Apostolos A., additional, Duffy, Kara, additional, Taylor, Ethel V., additional, Tolliver, Eric A., additional, Blanco, Carlos, additional, Compton, Wilson M., additional, Kimmel, Heather L., additional, Iafolla, Timothy, additional, Hyland, Andrew, additional, and Chaffee, Benjamin W., additional
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- 2022
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181. Implementation of a journal prototype for pregnant and parenting adolescents
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Bute, Jennifer J., Comer, Karen, Lauten, Kathryn M., Sanematsu, Helen Y., Moore, Courtney M., Lynch, Dustin, and Chumbler, Neale R.
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- 2014
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182. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab
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Matsumura, H., Matsuda, N., Kasugai, Y., Toyoda, A., Yashima, H., Sekimoto, S., Iwase, H., Oishi, K., Sakamoto, Y., Nakashima, H., Leveling, A., Boehnlein, D., Lauten, G., Mokhov, N., and Vaziri, K.
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- 2014
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183. Hämatologie
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Niemeyer, C. M., Lauten, M., Nowak-Göttl, U., Krümpel, A., Knöfler, R., Speer, Christian P., and Gahr, Manfred
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- 2009
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184. Predator exclosures, predator removal, and habitat improvement increase nest success of Snowy Plovers in Oregon, USA
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Dinsmore, Stephen J., Lauten, David J., Castelein, Kathleen A., Gaines, Eleanor P., and Stern, Mark A.
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- 2014
185. Extensive calcification of the mitral valve annulus in transcatheter aortic valve implants
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David Lopez Gonzalez, Harald Lapp, Philipp Lauten, Martin Haensig, Thomas Kuntze, and Tamer Owais
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Cardiac output ,medicine.medical_treatment ,Prosthesis ,Transcatheter Aortic Valve Replacement ,Internal medicine ,medicine ,Humans ,Ventricular outflow tract ,Mitral Valve Annulus ,Risk factor ,Heart Valve Prosthesis Implantation ,Annulus (mycology) ,Transcatheter aortic valve implantation ,Adult Cardiac ,AcademicSubjects/MED00920 ,business.industry ,Calcinosis ,Calcification pathology ,Original Articles ,Aortic Valve Stenosis ,Odds ratio ,medicine.disease ,Treatment Outcome ,Mitral valve annulus ,Aortic Valve ,Heart Valve Prosthesis ,cardiovascular system ,Cardiology ,Mitral Valve ,Female ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Calcification - Abstract
OBJECTIVES This study sought to report the calcification pattern of the mitral valve annulus and its implications for procedural and safety outcomes in transcatheter aortic valve implantation. METHODS Between November 2018 and September 2019, a total of 305 patients had transcatheter aortic valve implants at our institution. The extent of calcification of the mitral valve annulus was analysed, and the impact on safety outcomes was evaluated. RESULTS The prevalence of mitral annular calcification (MAC) was 43%. Calcification of the mitral valve annulus was either less than or at least one-third of the posterior annulus (34% and 32%), the whole posterior annulus (28%) or the extension to the attachment of the anterior leaflets (7%). Severe circumferential MAC revealed moderate paravalvular leaks in 5/8 (63%) patients and was associated with right branch bundle block [odds ratio (OR) 2.01 (0.39–3.06); P = 0.098] and low cardiac output [OR 3.12 (1.39–7.04); P = 0.033]. Subannular calcification at the anterolateral trigonum represented a risk factor for left ventricular outflow tract injury [OR 3.54 (1.38–8.27); P = 0.001] in balloon-expandable valves, associated with relevant rhythm disorders [OR 2.26 (1.17–5.65); P = 0.014] and female gender (7/8, 88%). The 30-day all-cause mortality in circumferential MAC reaching into the anterior annulus (grade IV) compared to patients with less MAC (grade I–III) was 13% vs 2% with a mean valve size of 24.6 vs 25.7 mm. CONCLUSIONS Extensive MAC was associated with moderate paravalvular leaks, with implications for the prosthesis size and survival in transcatheter aortic valve implants. In severe MAC, we recommend implanting oversized self-expandable prostheses, the goal being to reduce the risk of right branch bundle block and paravalvular leaks. Subj collection 122, 125, Mitral annular calcification (MAC) represents a chronic degenerative process in the fibrous base of the mitral valve (MV) that more commonly affects the posterior rather than the anterior annulus [1].
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- 2021
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186. Blood Urea Nitrogen (BUN) is independently associated with mortality in critically ill patients admitted to ICU.
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Okan Arihan, Bernhard Wernly, Michael Lichtenauer, Marcus Franz, Bjoern Kabisch, Johanna Muessig, Maryna Masyuk, Alexander Lauten, Paul Christian Schulze, Uta C Hoppe, Malte Kelm, and Christian Jung
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Medicine ,Science - Abstract
Blood urea nitrogen (BUN) was reported to be associated with mortality in heart failure patients. We aimed to evaluate admission BUN concentration in a heterogeneous critically ill patient collective admitted to an intensive care unit (ICU) for prognostic relevance.A total of 4176 medical patients (67±13 years) admitted to a German ICU between 2004 and 2009 were included. Follow-up of patients was performed retrospectively between May 2013 and November 2013. Association of admission BUN and both intra-hospital and long-term mortality were investigated by Cox regression. An optimal cut-off was calculated by means of the Youden-Index.Patients with higher admission BUN concentration were older, clinically sicker and had more pronounced laboratory signs of multi-organ failure including kidney failure. Admission BUN was associated with adverse long-term mortality (HR 1.013; 95%CI 1.012-1.014; p28 mg/dL to case-controls ≤ 28mg/dL corrected for APACHE2 scores: BUN above 28 mg/dL remained associated with adverse outcome in a paired analysis with the difference being 5.85% (95%CI 1.23-10.47%; p = 0.02).High BUN concentration at admission was robustly associated with adverse outcome in critically ill patients admitted to an ICU, even after correction for co-founders including renal failure. BUN might constitute an independent, easily available and important parameter for risk stratification in the critically ill.
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- 2018
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187. Mathematics for the Student Scientist.
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Lauten, A. Darien and Lauten, Gary N.
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Describes the Earth Day-Forest Watch Program which introduces kindergarten through high school level students to field laboratory and satellite-data analysis methods for assessing the health of Eastern White Pine forest stands. (DDR)
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- 1998
188. TAVI With or Without Predilation: Trends From a Large, Propensity-Score Weighted German Aortic Valve Registry (GARY) Population
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Brunilda, Alushi, Alexander, Lauten, Umniye, Balaban, Eva, Herrmann, Andreas, Schaefer, Timm, Bauer, Andreas, Beckmann, Sabine, Bleiziffer, Christian, Frerker, Helge, Möllmann, Thomas, Walther, Raffi, Bekeredjian, Stephan, Ensminger, and Lenard, Conradi
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Transcatheter Aortic Valve Replacement ,Aortic Valve ,Humans - Abstract
Currently, it is unclear whether transcatheter aortic valve implantation (TAVI) without predilation (direct TAVI; d-TAVI) or with preimplantation balloon valvuloplasty (b-TAVI) provides similar clinical safety and efficacy. Therefore, we analyzed patients undergoing d-TAVI or b-TAVI for severe aortic stenosis (AS) with either self-expanding or balloon-expandable transcatheter heart valves (THVs) from the German Aortic Valve Registry (GARY).Between 2011 and 2017, a total of 44,783 TAVI patients were collected, with 25,717 (57.4%) receiving a balloon-expandable THV and 19,066 (42.6%) receiving a self-expanding THV. A propensity-score weighted model was used to compare d-TAVI vs b-TAVI regarding differences in outcome.B-TAVI was performed in 71% and d-TAVI was performed in 29% of patients. In the investigated time interval, frequency of b-TAVI declined from 88.4% to 58.2%, accompanied by a constant rate of postdilation. After propensity weighting of patients receiving balloon-expandable THV, d-TAVI vs b-TAVI was associated with more frequent postoperative transvalvular mean pressure gradients (mPG)15 mm Hg (20.7% vs 18.4%; P.001), similar rates of paravalvular leakage (PVL) ≥ moderate (18.0% vs 16.9%; P=.08), fewer postdilations (13.4% vs 15.5%; P.001), and fewer complications (permanent pacemaker implantation, 10.2% vs 11.9% [P=.01]; vascular complications, 1.9% vs 2.6% [P.01]; pericardial tamponade, 0.5% vs 0.9% [P.01]; and stroke, 0.9% vs 1.3% [P=.02]). In patients receiving self-expanding THVs, d-TAVI vs b-TAVI was associated with more frequent postimplantation mean PG ≥ 15 mm Hg (12.7% vs 10.4%; P.01), higher rates of PVL ≥ moderate (24.8% vs 16.5%; P.001), and similar complication rates including permanent pacemaker implantation.The safety and efficacy of d-TAVI vs b-TAVI depends on the type of THV implanted. For balloon-expandable valves, d-TAVI provides an advantage, while self-expanding valves offer a similar safety profile for d-TAVI compared with b-TAVI. However, increased mPG post intervention with both valve types and more significant PVL in self-expanding THVs emphasize the importance of proper patient selection and evaluation of valve anatomy to identify suitable cases for d-TAVI.
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- 2022
189. Impact of TTVR on reverse remodeling of right-ventricular function and morphology in patients with severe tricuspid regurgitation
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Y Primet, N M Menck, B A Alushi, O B Bisht, S L Loser, C D Duddek, J G Geweiler, S A Alsheri, K V Vathie, S B Beuster, F S Steinborn, V M Mattea, A S Schade, J S M Schulz-Menger, and A L Lauten
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Cardiology and Cardiovascular Medicine - Abstract
Background Tricuspidregurgitation (TR) is recognized as majorpublic health concern with significant impact on morbidity and mortality. Multiple innovative approaches for transcatheter tricuspidvalve repair (TTVR) are currently under development, however their impact on cardiac function and outcome is still unclear. Cardiac Magnetic Resonance Imaging (CMRI) is considered as reference technique for right ventricular (RV) volumetric and functional measurements. Therefore, the purpose of the present study was to evaluate the impact of TTVR with the TriClip Technique on CMRI measured RV function and morphology. Methods and results Pre- and postprocedural to TTVR, RV function and morphology were evaluated in CMRI. Clinical outcome and quality of life were evaluated based on New York Heart Association (NYHA) class and the KCCQ-Score at baseline and within 30 days after Triclip Implantation. In total, 16 patients underwent pre and post procedural CMRI. Mean age was 78.9±0.5 years, with 42.8% were male (n=7). All patients presented functional TR. Mean RV end-diastolic volume (RVEDV) and RV end-systolic volume (RVESV) at baseline were 192.7ml ±25.85ml and 97.9ml ±0.51ml, RV stroke volume (RVSV) was 94.84ml and the RV ejection fraction (RVEF) was 49.5%. After a meanfollow-up of 19.6±1.1d, RVEDV and RVESV haddecreased to 181.7ml ±0.01ml and 85.5 ml ±5.95ml, respectively. The RVSV and RVEF increased to 94.2ml ±8.15ml and 53.1% ±0.14%, respectively. The quality of life evaluation showed an improvement of KCCQ-Score in 13/16 patients and remained unchanged or worsened in 3/16 patients. Conclusion In this pilot study, we observed an improvement of RV function as well as a reduction of RVEDV and RVESV after TTVR. These functional and morphometric changes induced by TTVR suggest a more efficient RV stroke work. This was associated with an improved quality of life according to KCCQ-Score in the majority of patients. Funding Acknowledgement Type of funding sources: Private hospital(s). Main funding source(s): Helios Klinikum Erfurt
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- 2022
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190. Impact of atrial flow regulator implantation on survival in patients with heart failure with reduced and preserved ejection fraction: a post-hoc analysis of the PRELIEVE study
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L Lauder, M Bergmann, C Paitazoglou, R Ozdemir, C Iliadis, J Bartunek, A Lauten, T Keller, S Weber, H Sievert, S D Anker, and F Mahfoud
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Cardiology and Cardiovascular Medicine - Abstract
Purpose This analysis aims to assess the theoretical impact of atrial flow regulator implantation on mortality by comparing the observed survival rate with the median predicted probability for one-year survival. Methods The prospective, multicentre, open-label, non-randomised PRELIEVE study assessed the safety and efficacy of the atrial flow regulator in patients with symptomatic HFrEF (left ventricular ejection fraction (LVEF) ≥15% and Results A total of 87 patients had undergone successful device implantation for the treatment of HFrEF (53%) and HFpEF (47%). Sixty patients had a complete twelve-month follow-up. The median follow-up was 351 days (interquartile range [IQR] 202–370). A total of six (7%) patients died during follow-up (8.6 deaths per 100 patient-years; 95% confidence interval [CI] 2.7 to 15.5), all of which had HFrEF. The median predicted mortality rate for the overall study population was 12.2 deaths per 100 patient-years (95% CI 10.2 to 14.7). While the observed mortality rate (0 deaths per 100 patient-years) was significantly lower than the median predicted mortality rate (9.3 deaths per 100 patient-years; 95% CI 8.4 to 11.1) in patients with HFpEF (−9.3 deaths per 100 patient-years; 95% CI −11.1 to −8.4), there was no difference in patients with HFrEF (−3.6 deaths per 100 patient-years; 95% CI −9.5 to 3.0) (Figure 1). Four deaths were HF-related deaths (5.7 HF-related deaths per 100 patient-years; 95% CI 1.4 to 11.9; 10.8 HF-related deaths per 100 patient-years; 95% CI 2.5 to 23.1 in the HFrEF subgroup). Conclusion In patients with HFpEF, the mortality rate following atrial flow regulator implantation was lower than the predicted mortality rate. These findings need to be confirmed by larger randomised, controlled trials. Funding Acknowledgement Type of funding sources: Private company. Main funding source(s): Occlutech International AB
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- 2022
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191. Allogeneic-matched sibling stem cell transplantation in a 13-year-old boy with ataxia telangiectasia and EBV-positive non-Hodgkin lymphoma
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Beier, R, Sykora, K-W, Woessmann, W, Maecker-Kolhoff, B, Sauer, M, Kreipe, H H, Dörk-Bousset, T, Kratz, C, and Lauten, M
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- 2016
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192. Are radiation-induced cavernomas clinically relevant findings? Results from long-term follow-up with brain magnetic resonance imaging of childhood cancer survivors
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Melchior Lauten, Christian Staackmann, Judith Gebauer, Hannes Schacht, Jan Küchler, Ulf Jensen-Kondering, Lucas Becker, Thorsten Langer, Peter Schramm, and Alexander Neumann
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Male ,Hemangioma, Cavernous, Central Nervous System ,Neoplasms, Radiation-Induced ,Time Factors ,R895-920 ,Medical physics. Medical radiology. Nuclear medicine ,Cancer Survivors ,hemic and lymphatic diseases ,Meningeal Neoplasms ,cavernomas ,Child ,Acute leukemia ,medicine.diagnostic_test ,Brain Neoplasms ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Magnetic Resonance Imaging ,Leukemia, Myeloid, Acute ,Oncology ,Child, Preschool ,Acute Disease ,brain magnetic resonance imaging ,Female ,Radiology ,hemorrhage ,Meningioma ,Research Article ,medicine.medical_specialty ,Adolescent ,Long term follow up ,childhood cancer survivors ,Childhood cancer ,Brain tumor ,cranial radiotherapy ,Radiation Dosage ,Young Adult ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Brain magnetic resonance imaging ,Cerebral Hemorrhage ,Retrospective Studies ,Medulloblastoma ,Cranial radiotherapy ,business.industry ,Infant ,Magnetic resonance imaging ,medicine.disease ,Cranial Irradiation ,business ,Follow-Up Studies - Abstract
Introduction Radiation-induced cavernomas (RIC) after cranial radiotherapy have an unknown risk of hemorrhage. Zabramski magnetic resonance imaging (MRI) classification is touted as being able to indicate non-radiation-induced cavernomas hemorrhage risk. The aim of our study was to assess the hemorrhage risk of RIC during long-term follow-up of childhood cancer survivors based on brain MRI examinations. Patients and methods We analyzed retrospectively long-term follow-up data of 36 childhood cancer survivors after initial diagnosis with acute leukemia (n = 18) or brain tumor (n = 18), all treated with cranial radiotherapy. Detected RIC in long-term follow-up brain MRI (1.5 or 3 Tesla) were classified following the Zabramski MRI classification and were categorized into “high” (Zabramski type I, II or V) or “low” (type III or IV) risk of hemorrhage. Results 18 patients (50%) showed RIC with a significant relation to the original tumor entity (p = 0.023) and the cumulative radiation dose to the brain (p = 0.016): all 9 childhood cancer survivors diagnosed with medulloblastoma developed RIC. We classified RIC in only 3/36 childhood cancer survivors (8%) (1 patient with acute lymphoblastic leukemia [Zabramski type II] and 2 patients with medulloblastoma [type I and type II]) as high risk for hemorrhage, the remaining RIC were classified as Zabramski type IV with low risk for hemorrhage. None of the childhood cancer survivors with RIC showed symptomatic hemorrhages. Conclusions RIC are common late effects in childhood cancer survivors treated with cranial radiotherapy affecting half of these patients. However, only a few RIC (occurring in 8% of all reviewed childhood cancer survivors) were classified as high risk for hemorrhage and none of the childhood cancer survivors with RIC developed symptomatic hemorrhages. Thus, we conclude that RIC are low-risk findings in brain MRI and the course is mainly benign.
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- 2021
193. Outcomes of transcatheter tricuspid valve intervention by right ventricular function: a multicentre propensity-matched analysis
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Vanessa Moñivas, Rebecca T. Hahn, Christian Besler, Giovanni Pedrazzini, Florian Schlotter, Fabien Praz, Adrian Attinger-Toller, Matthias Unterhuber, Georg Nickenig, Hannes Alessandrini, Felix Kreidel, Paolo Denti, Alberto Pozzoli, Sabine de Bruijn, Martin B. Leon, Brunilda Alushi, Karl-Philipp Rommel, Jörg Hausleiter, Michel Zuber, Gilbert H.L. Tang, Michael Mehr, Francesco Maisano, Maximilian von Roeder, Dominique Himbert, Ralph Stephan von Bardeleben, Joachim Schofer, Rishi Puri, Alec Vahanian, Alexander Lauten, Philipp Lurz, Mizuki Miura, Mirjam G. Wild, Daniel Kalbacher, Sebastian Ludwig, Mara Gavazzoni, Marcel Weber, J.-M. Juliard, Stephan Windecker, Edith Lubos, Karl-Patrik Kresoja, John G. Webb, Luigi Biasco, Maurizio Taramasso, Ulrich Schäfer, Daniel Braun, Azeem Latib, Horst Sievert, Neil Fam, Josep Rodés-Cabau, Eric Brochet, Rodrigo Estévez-Loureiro, Ryan Kaple, Tamim Nazif, Edwin C. Ho, Kim A. Connelly, and Holger Thiele
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medicine.medical_specialty ,education.field_of_study ,Tricuspid valve ,Ventricular function ,business.industry ,Ventricular Dysfunction, Right ,Mortality rate ,Hazard ratio ,Population ,Tertiary care ,Tricuspid Valve Insufficiency ,Treatment Outcome ,medicine.anatomical_structure ,Internal medicine ,Propensity score matching ,Cohort ,Ventricular Function, Right ,medicine ,Cardiology ,Humans ,Tricuspid Valve ,Cardiology and Cardiovascular Medicine ,education ,business - Abstract
BACKGROUND Tricuspid regurgitation (TR) has a poor prognosis and limited treatment options and is frequently accompanied by right ventricular (RV) dysfunction. Transcatheter tricuspid valve interventions (TTVI) to reduce TR have been shown to be safe and feasible with encouraging early results. Patient selection for TTVI remains challenging, with the role of right ventricular (RV) function being unknown. AIMS The aims of this study were 1) to investigate survival in a TTVI-treated patient population and a conservatively treated TR population, and 2) to evaluate the outcome of TTVI as compared to conservative treatment stratified according to the degree of RV function. METHODS We studied 684 patients from the multicentre TriValve cohort (TTVI cohort) and compared them to 914 conservatively treated patients from two tertiary care centres. Propensity matching identified 213 pairs of patients with severe TR. As we observed a non-linear relationship of RV function and TTVI outcome, we stratified patients according to tricuspid annular plane systolic excursion (TAPSE) to preserved (TAPSE >17 mm), mid-range (TAPSE 13-17 mm) and reduced (TAPSE
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- 2021
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194. Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study
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Fronczek, J, Polok, K, de Lange, D, Jung, C, Beil, M, Rhodes, A, Fjolner, J, Gorka, J, Andersen, F, Artigas, A, Cecconi, M, Christensen, S, Joannidis, M, Leaver, S, Marsh, B, Morandi, A, Moreno, R, Oeyen, S, Agvald-Ohman, C, Bollen Pinto, B, Schefold, J, Valentin, A, Walther, S, Watson, X, Zafeiridis, T, Sviri, S, van Heerden, P, Flaatten, H, Guidet, B, Szczeklik, W, Schmutz, R, Wimmer, F, Eller, P, De Buysscher, P, De Neve, N, Swinnen, W, Abraham, P, Hergafi, L, Biskup, E, Piza, P, Taliadoros, I, Dey, N, Solling, C, Rasmussen, B, Forceville, X, Besch, G, Mentec, H, Michel, P, Mateu, P, Vettoretti, L, Bourenne, J, Marin, N, Guillot, M, Aissaoui, N, Goulenok, C, Thieulot-Rolin, N, Messika, J, Lamhaut, L, Charron, C, Lauten, A, Sacher, A, Brenner, T, Franz, M, Bloos, F, Ebelt, H, Schaller, S, Fuest, K, Rabe, C, Dieck, T, Steiner, S, Graf, T, Nia, A, Janosi, R, Meybohm, P, Simon, P, Utzolino, S, Rahmel, T, Barth, E, Schuster, M, Aidoni, Z, Aloizos, S, Tasioudis, P, Lampiri, K, Zisopoulou, V, Ravani, I, Pagaki, E, Antoniou, A, Katsoulas, T, Kounougeri, A, Marinakis, G, Tsimpoukas, F, Spyropoulou, A, Zygoulis, P, Kyparissi, A, Gupta, M, Gurjar, M, Maji, I, Hayes, I, Kelly, Y, Westbrook, A, Fitzpatrick, G, Maheshwari, D, Motherway, C, Negri, G, Spadaro, S, Nattino, G, Pedeferri, M, Boscolo, A, Rossi, S, Calicchio, G, Cubattoli, L, Di Lascio, G, Barbagallo, M, Berruto, F, Codazzi, D, Bottazzi, A, Fumagalli, P, Negro, G, Lupi, G, Savelli, F, Vulcano, G, Fumagalli, R, Marudi, A, Lefons, U, Lembo, R, Babini, M, Paggioro, A, Parrini, V, Zaccaria, M, Clementi, S, Gigliuto, C, Facondini, F, Pastorini, S, Munaron, S, Calamai, I, Bocchi, A, Adorni, A, Bocci, M, Cortegiani, A, Casalicchio, T, Mellea, S, Graziani, E, Barattini, M, Brizio, E, Rossi, M, Hahn, M, Kemmerer, N, Strietzel, H, Dybwik, K, Legernaes, T, Klepstad, P, Olaussen, E, Olsen, K, Brresen, O, Bjorsvik, G, Maini, S, Fehrle, L, Czuczwar, M, Krawczyk, P, Zietkiewicz, M, Nowak, L, Kotfis, K, Cwyl, K, Gajdosz, R, Biernawska, J, Bohatyrewicz, R, Gawda, R, Grudzien, P, Nasilowski, P, Popek, N, Cyrankiewicz, W, Wawrzyniak, K, Wnuk, M, Maciejewski, D, Studzinska, D, Zukowski, M, Bernas, S, Piechota, M, Nowak-Kozka, I, Serwa, M, Machala, W, Stefaniak, J, Wujtewicz, M, Maciejewski, P, Szymkowiak, M, Adamik, B, Catorze, N, Branco, M, Barros, N, Barros, I, Krystopchuk, A, Honrado, T, Sousa, C, Munoz, F, Rebelo, M, Gomes, R, Nunes, J, Dias, C, Fernandes, A, Petrisor, C, Constantin, B, Belskiy, V, Boskholov, B, Rodriguez, E, Aguilar, G, Masdeu, G, Jaimes, M, Mira, A, Bodi, M, Mendoza, J, Lopez-Cuenca, S, Guzman, M, Rico-Feijoo, J, Ibarz, M, Alvarez, J, Kawati, R, Sivik, J, Nauska, J, Smole, D, Parenmark, F, Lyren, J, Rockstroh, K, Ryden, S, Spangfors, M, Strinnholm, M, De Geer, L, Nordlund, P, Palsson, S, Zetterquist, H, Nilsson, A, Thiringer, K, Jungner, M, Bark, B, Nordling, B, Skold, H, Brorsson, C, Persson, S, Bergstrom, A, Berkius, J, Holmstrom, J, van Dijk, I, van Lelyveld-Haas, L, Jansen, T, Nooteboom, F, van der Voort, P, Dieperink, W, de Waard, M, de Smet, A, Bormans, L, Dormans, T, Dempsey, G, Mathew, S, Raj, A, Grecu, I, Cupitt, J, Lawton, T, Clark, R, Popescu, M, Spittle, N, Faulkner, M, Cowton, A, Williams, P, Elloway, E, Reay, M, Chukkambotla, S, Kumar, R, Al-Subaie, N, Kent, L, Tamm, T, Kajtor, I, Burns, K, Pugh, R, Ostermann, M, Kam, E, Bowyer, H, Smith, N, Templeton, M, Henning, J, Goffin, K, Kapoor, R, Laha, S, Chilton, P, Khaliq, W, Crayford, A, Coetzee, S, Tait, M, Stoker, W, Gimenez, M, Pope, A, Camsooksai, J, Pogson, D, Quigley, K, Ritzema, J, Hormis, A, Boulanger, C, Balasubramaniam, M, Vamplew, L, Burt, K, Martin, D, Craig, J, Prowle, J, Doyle, N, Shelton, J, Scott, C, Donnison, P, Shelton, S, Frey, C, Ryan, C, Spray, D, Barnes, V, Barnes, K, Ridgway, S, Saha, R, Clark, T, Wood, J, Bolger, C, Bassford, C, Lewandowski, J, Zhao, X, Humphreys, S, Dowling, S, Richardson, N, Burtenshaw, A, Stevenson, C, Wilcock, D, Nalapko, Y, Helbok, R, Nollet, J, de Neve, N, Mikacic, M, Bastiansen, A, Husted, A, Dahle, B, Cramer, C, Orsnes, D, Thomsen, J, Pedersen, J, Enevoldsen, M, Elkmann, T, Kubisz-Pudelko, A, Collins, A, Hart, C, Randell, G, Filipe, H, Welters, I, Evans, J, Lord, J, Jones, J, Ball, J, North, J, Salaunkey, K, De Gordoa, L, Bell, L, Vizcaychipi, M, Mupudzi, M, Lea-Hagerty, M, Spivey, M, Love, N, White, N, Morgan, P, Wakefield, P, Savine, R, Jacob, R, Innes, R, Rose, S, Mane, T, Ogbeide, V, Baird, Y, Romen, A, Galbois, A, Vinsonneau, C, Thevenin, D, Guerot, E, Savary, G, Chagnon, J, Rigaud, J, Quenot, J, Castaneray, J, Rosman, J, Maizel, J, Tiercelet, K, Hovaere, M, Messika, M, Djibre, M, Rolin, N, Burtin, P, Garcon, P, Nseir, S, Valette, X, Horacek, M, Bruno, R, Allgauer, S, Dubler, S, Schering, S, Koutsikou, A, Vakalos, A, Raitsiou, B, Flioni, E, Neou, E, Papathanakos, G, Koutsodimitropoulos, I, Aikaterini, K, Rovina, N, Kourelea, S, Polychronis, T, Zidianakis, V, Konstantinia, V, Read, C, Martin-Loeches, I, Cracchiolo, A, Morigi, A, Brusa, S, Elhadi, A, Tarek, A, Khaled, A, Ahmed, H, Belkhair, W, Cornet, A, Gommers, D, van Boven, E, Haringman, J, Haas, L, van den Berg, L, Hoiting, O, de Jager, P, Gerritsen, R, Breidablik, A, Slapgard, A, Rime, A, Jannestad, B, Sjoboe, B, Rice, E, Jensen, J, Langorgen, J, Toien, K, Strand, K, Biernacka, A, Kluzik, A, Kudlinski, B, Hymczak, H, Solek-Pastuszka, J, Zorska, J, Krzych, L, Lipinska-Gediga, M, Pietruszko, M, Kozera, N, Sendur, P, Zatorski, P, Galkin, P, Kosciuczuk, U, Gola, W, Pinto, A, Santos, A, Ferreira, I, Blanco, J, Carvalho, J, Maia, J, Candeias, N, Lores, A, Cilloniz, C, Perez-Torres, D, Maseda, E, Prol-Silva, E, Eixarch, G, Goma, G, Velasco, G, Villamayor, M, Fernandez, N, Cubero, P, Tomasa, T, Sjoqvist, A, Schioler, F, Westberg, H, Boroli, F, Eckert, P, Yildiz, I, Yovenko, I, Fronczek J., Polok K., de Lange D. W., Jung C., Beil M., Rhodes A., Fjolner J., Gorka J., Andersen F. H., Artigas A., Cecconi M., Christensen S., Joannidis M., Leaver S., Marsh B., Morandi A., Moreno R., Oeyen S., Agvald-Ohman C., Bollen Pinto B., Schefold J. C., Valentin A., Walther S., Watson X., Zafeiridis T., Sviri S., van Heerden P. V., Flaatten H., Guidet B., Szczeklik W., Schmutz R., Wimmer F., Eller P., De Buysscher P., De Neve N., Swinnen W., Abraham P., Hergafi L., Biskup E., Piza P., Taliadoros I., Dey N., Solling C., Rasmussen B. S., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Lauten A., Sacher A. L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S. J., Fuest K., Rabe C., Dieck T., Steiner S., Graf T., Nia A. M., Janosi R. A., Meybohm P., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T. A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Gupta M., Gurjar M., Maji I. M., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano G. A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M. G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., Hahn M., Kemmerer N., Strietzel H. F., Dybwik K., Legernaes T., Klepstad P., Olaussen E. B., Olsen K. I., Brresen O. M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L. R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz R., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak-Kozka I., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M. C., Barros N., Barros I., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., Dias C., Fernandes A. M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Rodriguez E., Aguilar G., Masdeu G., Jaimes M. I., Mira A. P., Bodi M. A., Mendoza J. A. B., Lopez-Cuenca S., Guzman M. H., Rico-Feijoo J., Ibarz M., Alvarez J. T., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Spangfors M., Strinnholm M., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., van Dijk I., van Lelyveld-Haas L. E. M., Jansen T., Nooteboom F., van der Voort P. H. J., de Lange D., Dieperink W., de Waard M. C., de Smet A. G. E., Bormans L., Dormans T., Dempsey G., Mathew S. J., Raj A. S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Williams P., Elloway E., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott C., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., Lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., Nalapko Y., Helbok R., Nollet J., de Neve N., Mikacic M., Bastiansen A., Husted A., Dahle B. E. S., Cramer C., Orsnes D., Thomsen J. E., Pedersen J. J., Enevoldsen M. H., Elkmann T., Kubisz-Pudelko A., Collins A., Hart C., Randell G., Filipe H., Welters I. D., Evans J., Lord J., Jones J., Ball J., North J., Salaunkey K., De Gordoa L. O. -R., Bell L., Vizcaychipi M., Mupudzi M., Lea-Hagerty M., Spivey M., Love N., White N., Morgan P., Wakefield P., Savine R., Jacob R., Innes R., Rose S., Mane T., Ogbeide V., Baird Y., Romen A., Galbois A., Vinsonneau C., Thevenin D., Guerot E., Savary G., Chagnon J. L., Rigaud J. P., Quenot J. P., Castaneray J., Rosman J., Maizel J., Tiercelet K., Hovaere M. M., Messika M., Djibre M., Rolin N., Burtin P., Garcon P., Nseir S., Valette X., Horacek M., Bruno R. R., Allgauer S., Dubler S., Schering S., Koutsikou A., Vakalos A., Raitsiou B., Flioni E. N., Neou E., Papathanakos G., Koutsodimitropoulos I., Aikaterini K., Rovina N., Kourelea S., Polychronis T., Zidianakis V., Konstantinia V., Read C., Martin-Loeches I., Cracchiolo A. N., Morigi A., Brusa S., Elhadi A., Tarek A., Khaled A., Ahmed H., Belkhair W. A., Cornet A. D., Gommers D., van Boven E., Haringman J., Haas L., van den Berg L., Hoiting O., de Jager P., Gerritsen R. T., Breidablik A., Slapgard A., Rime A. K., Jannestad B., Sjoboe B., Rice E., Jensen J. P., Langorgen J., Toien K., Strand K., Biernacka A., Kluzik A., Kudlinski B., Hymczak H., Solek-Pastuszka J., Zorska J., Krzych L. J., Lipinska-Gediga M., Pietruszko M., Kozera N., Sendur P., Zatorski P., Galkin P., Kosciuczuk U., Gola W., Pinto A. F., Santos A. R., Ferreira I. A., Blanco J. B., Carvalho J. T., Maia J., Candeias N., Lores A., Cilloniz C., Perez-Torres D., Maseda E., Prol-Silva E., Eixarch G., Goma G., Velasco G. N., Villamayor M. I., Fernandez N. L., Cubero P. J., Tomasa T., Sjoqvist A., Schioler F., Westberg H., Thiringer K. K., Boroli F., Eckert P., Yildiz I., Yovenko I., Fronczek, J, Polok, K, de Lange, D, Jung, C, Beil, M, Rhodes, A, Fjolner, J, Gorka, J, Andersen, F, Artigas, A, Cecconi, M, Christensen, S, Joannidis, M, Leaver, S, Marsh, B, Morandi, A, Moreno, R, Oeyen, S, Agvald-Ohman, C, Bollen Pinto, B, Schefold, J, Valentin, A, Walther, S, Watson, X, Zafeiridis, T, Sviri, S, van Heerden, P, Flaatten, H, Guidet, B, Szczeklik, W, Schmutz, R, Wimmer, F, Eller, P, De Buysscher, P, De Neve, N, Swinnen, W, Abraham, P, Hergafi, L, Biskup, E, Piza, P, Taliadoros, I, Dey, N, Solling, C, Rasmussen, B, Forceville, X, Besch, G, Mentec, H, Michel, P, Mateu, P, Vettoretti, L, Bourenne, J, Marin, N, Guillot, M, Aissaoui, N, Goulenok, C, Thieulot-Rolin, N, Messika, J, Lamhaut, L, Charron, C, Lauten, A, Sacher, A, Brenner, T, Franz, M, Bloos, F, Ebelt, H, Schaller, S, Fuest, K, Rabe, C, Dieck, T, Steiner, S, Graf, T, Nia, A, Janosi, R, Meybohm, P, Simon, P, Utzolino, S, Rahmel, T, Barth, E, Schuster, M, Aidoni, Z, Aloizos, S, Tasioudis, P, Lampiri, K, Zisopoulou, V, Ravani, I, Pagaki, E, Antoniou, A, Katsoulas, T, Kounougeri, A, Marinakis, G, Tsimpoukas, F, Spyropoulou, A, Zygoulis, P, Kyparissi, A, Gupta, M, Gurjar, M, Maji, I, Hayes, I, Kelly, Y, Westbrook, A, Fitzpatrick, G, Maheshwari, D, Motherway, C, Negri, G, Spadaro, S, Nattino, G, Pedeferri, M, Boscolo, A, Rossi, S, Calicchio, G, Cubattoli, L, Di Lascio, G, Barbagallo, M, Berruto, F, Codazzi, D, Bottazzi, A, Fumagalli, P, Negro, G, Lupi, G, Savelli, F, Vulcano, G, Fumagalli, R, Marudi, A, Lefons, U, Lembo, R, Babini, M, Paggioro, A, Parrini, V, Zaccaria, M, Clementi, S, Gigliuto, C, Facondini, F, Pastorini, S, Munaron, S, Calamai, I, Bocchi, A, Adorni, A, Bocci, M, Cortegiani, A, Casalicchio, T, Mellea, S, Graziani, E, Barattini, M, Brizio, E, Rossi, M, Hahn, M, Kemmerer, N, Strietzel, H, Dybwik, K, Legernaes, T, Klepstad, P, Olaussen, E, Olsen, K, Brresen, O, Bjorsvik, G, Maini, S, Fehrle, L, Czuczwar, M, Krawczyk, P, Zietkiewicz, M, Nowak, L, Kotfis, K, Cwyl, K, Gajdosz, R, Biernawska, J, Bohatyrewicz, R, Gawda, R, Grudzien, P, Nasilowski, P, Popek, N, Cyrankiewicz, W, Wawrzyniak, K, Wnuk, M, Maciejewski, D, Studzinska, D, Zukowski, M, Bernas, S, Piechota, M, Nowak-Kozka, I, Serwa, M, Machala, W, Stefaniak, J, Wujtewicz, M, Maciejewski, P, Szymkowiak, M, Adamik, B, Catorze, N, Branco, M, Barros, N, Barros, I, Krystopchuk, A, Honrado, T, Sousa, C, Munoz, F, Rebelo, M, Gomes, R, Nunes, J, Dias, C, Fernandes, A, Petrisor, C, Constantin, B, Belskiy, V, Boskholov, B, Rodriguez, E, Aguilar, G, Masdeu, G, Jaimes, M, Mira, A, Bodi, M, Mendoza, J, Lopez-Cuenca, S, Guzman, M, Rico-Feijoo, J, Ibarz, M, Alvarez, J, Kawati, R, Sivik, J, Nauska, J, Smole, D, Parenmark, F, Lyren, J, Rockstroh, K, Ryden, S, Spangfors, M, Strinnholm, M, De Geer, L, Nordlund, P, Palsson, S, Zetterquist, H, Nilsson, A, Thiringer, K, Jungner, M, Bark, B, Nordling, B, Skold, H, Brorsson, C, Persson, S, Bergstrom, A, Berkius, J, Holmstrom, J, van Dijk, I, van Lelyveld-Haas, L, Jansen, T, Nooteboom, F, van der Voort, P, Dieperink, W, de Waard, M, de Smet, A, Bormans, L, Dormans, T, Dempsey, G, Mathew, S, Raj, A, Grecu, I, Cupitt, J, Lawton, T, Clark, R, Popescu, M, Spittle, N, Faulkner, M, Cowton, A, Williams, P, Elloway, E, Reay, M, Chukkambotla, S, Kumar, R, Al-Subaie, N, Kent, L, Tamm, T, Kajtor, I, Burns, K, Pugh, R, Ostermann, M, Kam, E, Bowyer, H, Smith, N, Templeton, M, Henning, J, Goffin, K, Kapoor, R, Laha, S, Chilton, P, Khaliq, W, Crayford, A, Coetzee, S, Tait, M, Stoker, W, Gimenez, M, Pope, A, Camsooksai, J, Pogson, D, Quigley, K, Ritzema, J, Hormis, A, Boulanger, C, Balasubramaniam, M, Vamplew, L, Burt, K, Martin, D, Craig, J, Prowle, J, Doyle, N, Shelton, J, Scott, C, Donnison, P, Shelton, S, Frey, C, Ryan, C, Spray, D, Barnes, V, Barnes, K, Ridgway, S, Saha, R, Clark, T, Wood, J, Bolger, C, Bassford, C, Lewandowski, J, Zhao, X, Humphreys, S, Dowling, S, Richardson, N, Burtenshaw, A, Stevenson, C, Wilcock, D, Nalapko, Y, Helbok, R, Nollet, J, de Neve, N, Mikacic, M, Bastiansen, A, Husted, A, Dahle, B, Cramer, C, Orsnes, D, Thomsen, J, Pedersen, J, Enevoldsen, M, Elkmann, T, Kubisz-Pudelko, A, Collins, A, Hart, C, Randell, G, Filipe, H, Welters, I, Evans, J, Lord, J, Jones, J, Ball, J, North, J, Salaunkey, K, De Gordoa, L, Bell, L, Vizcaychipi, M, Mupudzi, M, Lea-Hagerty, M, Spivey, M, Love, N, White, N, Morgan, P, Wakefield, P, Savine, R, Jacob, R, Innes, R, Rose, S, Mane, T, Ogbeide, V, Baird, Y, Romen, A, Galbois, A, Vinsonneau, C, Thevenin, D, Guerot, E, Savary, G, Chagnon, J, Rigaud, J, Quenot, J, Castaneray, J, Rosman, J, Maizel, J, Tiercelet, K, Hovaere, M, Messika, M, Djibre, M, Rolin, N, Burtin, P, Garcon, P, Nseir, S, Valette, X, Horacek, M, Bruno, R, Allgauer, S, Dubler, S, Schering, S, Koutsikou, A, Vakalos, A, Raitsiou, B, Flioni, E, Neou, E, Papathanakos, G, Koutsodimitropoulos, I, Aikaterini, K, Rovina, N, Kourelea, S, Polychronis, T, Zidianakis, V, Konstantinia, V, Read, C, Martin-Loeches, I, Cracchiolo, A, Morigi, A, Brusa, S, Elhadi, A, Tarek, A, Khaled, A, Ahmed, H, Belkhair, W, Cornet, A, Gommers, D, van Boven, E, Haringman, J, Haas, L, van den Berg, L, Hoiting, O, de Jager, P, Gerritsen, R, Breidablik, A, Slapgard, A, Rime, A, Jannestad, B, Sjoboe, B, Rice, E, Jensen, J, Langorgen, J, Toien, K, Strand, K, Biernacka, A, Kluzik, A, Kudlinski, B, Hymczak, H, Solek-Pastuszka, J, Zorska, J, Krzych, L, Lipinska-Gediga, M, Pietruszko, M, Kozera, N, Sendur, P, Zatorski, P, Galkin, P, Kosciuczuk, U, Gola, W, Pinto, A, Santos, A, Ferreira, I, Blanco, J, Carvalho, J, Maia, J, Candeias, N, Lores, A, Cilloniz, C, Perez-Torres, D, Maseda, E, Prol-Silva, E, Eixarch, G, Goma, G, Velasco, G, Villamayor, M, Fernandez, N, Cubero, P, Tomasa, T, Sjoqvist, A, Schioler, F, Westberg, H, Boroli, F, Eckert, P, Yildiz, I, Yovenko, I, Fronczek J., Polok K., de Lange D. W., Jung C., Beil M., Rhodes A., Fjolner J., Gorka J., Andersen F. H., Artigas A., Cecconi M., Christensen S., Joannidis M., Leaver S., Marsh B., Morandi A., Moreno R., Oeyen S., Agvald-Ohman C., Bollen Pinto B., Schefold J. C., Valentin A., Walther S., Watson X., Zafeiridis T., Sviri S., van Heerden P. V., Flaatten H., Guidet B., Szczeklik W., Schmutz R., Wimmer F., Eller P., De Buysscher P., De Neve N., Swinnen W., Abraham P., Hergafi L., Biskup E., Piza P., Taliadoros I., Dey N., Solling C., Rasmussen B. S., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Lauten A., Sacher A. L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S. J., Fuest K., Rabe C., Dieck T., Steiner S., Graf T., Nia A. M., Janosi R. A., Meybohm P., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T. A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Gupta M., Gurjar M., Maji I. M., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano G. A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M. G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., Hahn M., Kemmerer N., Strietzel H. F., Dybwik K., Legernaes T., Klepstad P., Olaussen E. B., Olsen K. I., Brresen O. M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L. R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz R., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak-Kozka I., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M. C., Barros N., Barros I., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., Dias C., Fernandes A. M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Rodriguez E., Aguilar G., Masdeu G., Jaimes M. I., Mira A. P., Bodi M. A., Mendoza J. A. B., Lopez-Cuenca S., Guzman M. H., Rico-Feijoo J., Ibarz M., Alvarez J. T., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Spangfors M., Strinnholm M., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., van Dijk I., van Lelyveld-Haas L. E. M., Jansen T., Nooteboom F., van der Voort P. H. J., de Lange D., Dieperink W., de Waard M. C., de Smet A. G. E., Bormans L., Dormans T., Dempsey G., Mathew S. J., Raj A. S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Williams P., Elloway E., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott C., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., Lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., Nalapko Y., Helbok R., Nollet J., de Neve N., Mikacic M., Bastiansen A., Husted A., Dahle B. E. S., Cramer C., Orsnes D., Thomsen J. E., Pedersen J. J., Enevoldsen M. H., Elkmann T., Kubisz-Pudelko A., Collins A., Hart C., Randell G., Filipe H., Welters I. D., Evans J., Lord J., Jones J., Ball J., North J., Salaunkey K., De Gordoa L. O. -R., Bell L., Vizcaychipi M., Mupudzi M., Lea-Hagerty M., Spivey M., Love N., White N., Morgan P., Wakefield P., Savine R., Jacob R., Innes R., Rose S., Mane T., Ogbeide V., Baird Y., Romen A., Galbois A., Vinsonneau C., Thevenin D., Guerot E., Savary G., Chagnon J. L., Rigaud J. P., Quenot J. P., Castaneray J., Rosman J., Maizel J., Tiercelet K., Hovaere M. M., Messika M., Djibre M., Rolin N., Burtin P., Garcon P., Nseir S., Valette X., Horacek M., Bruno R. R., Allgauer S., Dubler S., Schering S., Koutsikou A., Vakalos A., Raitsiou B., Flioni E. N., Neou E., Papathanakos G., Koutsodimitropoulos I., Aikaterini K., Rovina N., Kourelea S., Polychronis T., Zidianakis V., Konstantinia V., Read C., Martin-Loeches I., Cracchiolo A. N., Morigi A., Brusa S., Elhadi A., Tarek A., Khaled A., Ahmed H., Belkhair W. A., Cornet A. D., Gommers D., van Boven E., Haringman J., Haas L., van den Berg L., Hoiting O., de Jager P., Gerritsen R. T., Breidablik A., Slapgard A., Rime A. K., Jannestad B., Sjoboe B., Rice E., Jensen J. P., Langorgen J., Toien K., Strand K., Biernacka A., Kluzik A., Kudlinski B., Hymczak H., Solek-Pastuszka J., Zorska J., Krzych L. J., Lipinska-Gediga M., Pietruszko M., Kozera N., Sendur P., Zatorski P., Galkin P., Kosciuczuk U., Gola W., Pinto A. F., Santos A. R., Ferreira I. A., Blanco J. B., Carvalho J. T., Maia J., Candeias N., Lores A., Cilloniz C., Perez-Torres D., Maseda E., Prol-Silva E., Eixarch G., Goma G., Velasco G. N., Villamayor M. I., Fernandez N. L., Cubero P. J., Tomasa T., Sjoqvist A., Schioler F., Westberg H., Thiringer K. K., Boroli F., Eckert P., Yildiz I., and Yovenko I.
- Abstract
Background: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods: We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient’s age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. Results: The median age in the sample of 7487 consecutive patients was 84 years (IQR 81–87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01). Conclusion: Knowledge about a patient’s frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2)
- Published
- 2021
195. Mitochondrial Regulation of Inflammation after Psychological Trauma
- Author
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Reed, Emily, primary, Lauten, Tatlock, additional, Clopp, Amelia, additional, Moshfegh, Cassandra, additional, Elkhatib, Safwan, additional, and Case, Adam, additional
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- 2022
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196. Impact of moderate or severe left ventricular outflow tract calcification on clinical outcomes of patients with severe aortic stenosis undergoing transcatheter aortic valve implantation with self- and balloon-expandable valves: a post hoc analysis from the SOLVE-TAVI trial
- Author
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Farhan, Serdar, primary, Stachel, Georg, additional, Desch, Steffen, additional, Kurz, Thomas, additional, Feistritzer, Hans-Josef, additional, Hartung, Philipp, additional, Eitel, Ingo, additional, Nef, Holger, additional, Doerr, Oliver, additional, Lauten, Alexander, additional, Landmesser, Ulf, additional, Sandri, Marcus, additional, Holzhey, David, additional, Borger, Michael, additional, Ince, Hüseyin, additional, Öner, Alper, additional, Meyer-Saraei, Roza, additional, Wienbergen, Harm, additional, Fach, Andreas, additional, Frey, Norbert, additional, de Waha-Thiele, Suzanne, additional, and Thiele, Holger, additional
- Published
- 2022
- Full Text
- View/download PDF
197. Gender-Specific Performance of One- Compared to Two-Catheter Concepts in Transradial Coronary Angiography – Insights From the Randomized UDDC-Radial-Trial
- Author
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Schneider, Vera S., primary, Lübking, Laura, additional, Stähli, Barbara E., additional, Skurk, Carsten, additional, Lauten, Alexander, additional, Mochmann, Hans-Christian, additional, Schauerte, Patrick, additional, Riedel, Matthias, additional, Steinbeck, Lisa, additional, Rauch-Kröhnert, Ursula, additional, Klotsche, Jens, additional, Landmesser, Ulf, additional, Fröhlich, Georg, additional, and Leistner, David M., additional
- Published
- 2022
- Full Text
- View/download PDF
198. Impact of atrial flow regulator implantation on survival in patients with heart failure with reduced and preserved ejection fraction: a post-hoc analysis of the PRELIEVE study
- Author
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Lauder, L, primary, Bergmann, M, additional, Paitazoglou, C, additional, Ozdemir, R, additional, Iliadis, C, additional, Bartunek, J, additional, Lauten, A, additional, Keller, T, additional, Weber, S, additional, Sievert, H, additional, Anker, S D, additional, and Mahfoud, F, additional
- Published
- 2022
- Full Text
- View/download PDF
199. Impact of TTVR on reverse remodeling of right-ventricular function and morphology in patients with severe tricuspid regurgitation
- Author
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Primet, Y, primary, Menck, N M, additional, Alushi, B A, additional, Bisht, O B, additional, Loser, S L, additional, Duddek, C D, additional, Geweiler, J G, additional, Alsheri, S A, additional, Vathie, K V, additional, Beuster, S B, additional, Steinborn, F S, additional, Mattea, V M, additional, Schade, A S, additional, Schulz-Menger, J S M, additional, and Lauten, A L, additional
- Published
- 2022
- Full Text
- View/download PDF
200. Aortic valve calcium volume as measured by native versus contrast-enhanced computer tomography and the implications for the diagnosis of severe aortic stenosis in TAVR patients with low-gradient aortic stenosis
- Author
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El Garhy, Mohammad, primary, Owais, Tamer, additional, and Lauten, Philipp, additional
- Published
- 2022
- Full Text
- View/download PDF
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