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154. Results of knee manipulations after anterior cruciate ligament reconstructions

Author

Dodds, Julie A., Keene, James S., Graf, Ben K., and Lange, Richard H.

Subjects
Anterior cruciate ligament, Joints -- Range of motion, Knee -- Injuries, Health, Sports and fitness
Abstract

The anterior cruciate ligament (ACL) is essential for knee movement and stability. Injuries or tears involving this ligament can lead to severe limitations of knee mobility. Surgical reconstruction is often used to treat ACL injuries, but complications often occur after these procedures are performed. Knee manipulations are procedures in which the range of motion at the knee is increased manually while the patient is under anesthesia. These procedures can also have complications. This study examined the results of knee manipulations in patients that have had ACL reconstruction. Of 336 ACL reconstructions during a three-year period, 46 (14 percent) involved patients needing knee manipulations afterwards. Long-term evaluations were available for 42 of the 46 knees following the manipulations. Results showed knee flexion (bending ability) was less than 90 degrees in 17 knees and greater than 90 degrees in 25 knees prior to manipulation. This increased to 125 degrees and 132 degrees, respectively, following manipulation. The difference between the two groups following manipulation was not significant. There were no significant differences when manipulation was performed either earlier than six months or later than six months following ACL reconstruction. Deficits in the ability to extend the knee (bring the leg toward a straight condition; the opposite of flexing) were less than 15 degrees in 23 knees and greater than 15 degrees in 19 knees prior to manipulation. Following manipulation, these values were 1.3 degrees and 6.8 degrees respectively, a significant difference. Thus the knees with extension deficits greater than 15 degrees before undergoing manipulation were not able to extend as much afterwards as knees with smaller initial deficits. These results showed that knee manipulations following ACL reconstruction were generally safe and effective, with the amount of time between surgery and manipulation and the extent of premanipulation flexion not affecting outcome. Knee extension prior to manipulation was related to outcome, however. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

156. Ethanol-induced coronary vasodilation in patients with and without coronary artery disease

Author

Cigarroa, Ricardo G., Lange, Richard A., Popma, Jeffrey J., Yurow, Gary, Sills, Michael N., Firth, Brian G., and Hillis, L. David

Subjects
Coronary arteries, Coronary heart disease, Alcohol -- Physiological aspects, Health
Abstract

The effects of ethanol on blood flow in the coronary arteries, the major blood vessels supplying the heart, and the dimensions of the coronary arteries were examined in 29 patients with coronary artery disease and six normal subjects. Blood flow was measured in the coronary sinus, a large vein that drains coronary arteries, before and during a 15- to 30-minute infusion of dextrose, or sugar, into the hearts of 15 subjects and an infusion of 5 percent ethanol in dextrose solution in 20 subjects. In subjects receiving dextrose, heart rate, arterial pressure, and coronary sinus blood flow were unchanged. In subjects receiving ethanol, coronary sinus flow increased about 27 percent, and resistance in the coronary blood vessels to flow decreased 17 percent. In the ethanol group, there were also changes in the oxygen content in the coronary artery sinus and artery, but no changes in the coronary artery dimensions. The results show that ethanol increases coronary blood flow and decreases resistance without causing any changes in dimensions, suggesting that the effects of ethanol result from dilation of the small blood vessels called arterioles, which cause resistance to flow. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

166. Acquired myocardial bridging

Author

Vongpatanasin, Wanpen, Willard, John E., Hillis, L. David, Lange, Richard A., and Landau, Charles

Published
1997

168. Prosthetic Heart Valves

Author

Vongpatanasin, Wanpen, Hillis, L. David, and Lange, Richard A.

Published
1997

172. Intranasal nicotine spray does not augment the adverse effects of cigarette smoking on myocardial oxygen demand or coronary arterial dimensions

Author

Keeley, Ellen C., Pirwitz, Mark J., Landau, Charles, Lange, Richard A., Hillis, L. David, Foerster, Ebb H., Conrad, Kelly, and Willard, John E.

Subjects
Tobacco habit -- Care and treatment, Nicotine -- Health aspects, Oxygen in the body -- Measurement, Health, Health care industry
Abstract

PURPOSE: Nicotine replacement therapy has become a popular therapy for smokers attempting to stop smoking. Unfortunately, some subjects continue to smoke while receiving it. Since nicotine is believed to be the primary constituent of cigarette smoke responsible for its acute adverse effects on myocardial oxygen supply and demand, concomitant nicotine replacement therapy and smoking theoretically could provoke a marked decrease in myocardial oxygen supply and increase in demand. This study was performed to assess the effects of cigarette smoking with and without concomitant intranasal nicotine spray on: (a) myocardial oxygen demand, (b) coronary arterial dimensions, and (c) the development of acute cardiovascular tolerance. PATIENTS AND METHODS: In 19 smokers referred for cardiac catheterization for the evaluation of chest pain, we assessed the effects of cigarette smoking with and without concomitant intranasal nicotine spray on. (a) heart rate-systolic arterial pressure product lan estimate of myocardial oxygen demand), (b) coronary arterial dimensions (measured with computer-assisted quantitative arteriography), and (c) the development of acute cardiovascular tolerance. RESULTS: Smoking a first cigarette increased rate pressure product (P

Published
1996

174. South Fork Kings.

Author

LANGE, RICHARD M.

Subjects
SOUTH Fork Kings (Short story), LANGE, Richard M.
Published
2021

175. Gamut of cardiac manifestations and complications of COVID-19: a contemporary review.

Author

Rodriguez, Jose Benjamin Cruz, Lange, Richard A., and Mukherjee, Debabrata

Abstract

COVID-19 has posed an extraordinary burden on health and the economy worldwide. Patients with cardiovascular diseases are more likely to have severe illness due to COVID-19 and are at increased risk for complications and mortality. We performed a narrative literature review to assess the burden of COVID-19 and cardiovascular morbidity and mortality. Myocardial injury has been reported in 20%-30% of patients hospitalized due to COVID-19 and is associated with a worse prognosis and high mortality (~50%-60%). Proposed mechanisms of myocardial injury include inflammation within the myocardium (due to direct viral infection or cytokine storm), endotheliitis, coronary vasculitis, myocarditis, demand ischemia, plaque destabilization and right ventricular failure. The right ventricle is particularly vulnerable to injury and failure in COVID-19-infected patients, given the hypoxic pulmonary vasoconstriction, pulmonary microthrombi or pulmonary embolism. Echocardiography is an effective and accessible tool to evaluate left and right ventricular functions and risk stratify patients with COVID-19 infection. Cardiac MRI has detected and characterized myocardial injury, with changes compatible with other inflammatory cardiomyopathies. The long-term consequences of these inflammatory changes are unknown, but accumulating data will provide insight regarding the longitudinal impact of COVID-19 infection on cardiovascular morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2020
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178. Coronary angioplasty in the patient with acute myocardial infarction

Author

Landau, Charles, Glamann, D. Brent, Willard, John E., Hillis, L. David, and Lange, Richard A.

Subjects
Heart attack, Transluminal angioplasty -- Evaluation, Health, Health care industry
Abstract

In patients with acute myocardial infarction, percutaneous transluminal coronary angioplasty (PTCA) may be used (1) to restore antegrade flow in the infarct artery (so called 'primary' PTCA) instead of thrombolytic therapy, (2) to establish antegrade coronary flow after unsuccessful thrombolytic therapy (so called 'rescue' or 'salvage' PTCA), and (3) to reduce the residual infarct artery stenosis after successful thrombolysis. This review examines the prospective, randomized studies that have addressed the use of PTCA for each of these purposes. In selected circumstances, PTCA is a reasonable alternative to thrombolytic therapy in patients with evolving or recent Q-wave myocardial infarction. In those patients with acute myocardial infarction complicated by cardiogenic shock, PTCA may be the preferred treatment. After thrombolytic therapy, the use of PTCA in the absence of spontaneous or provocable ischemia offers no benefit with regard to left ventricular function or survival. in this circumstance, its use is associated with an excessive risk of bleeding, transfusions, and emergent coronary artery bypass surgery when performed within hours of infarction.

Published
1994

179. Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis

Author

Moliterno, David J., Lange, Richard A., Gerard, Robert D., Willard, John E., Lackner, Carolin, and Hillis, L. David

Subjects
Cocaine abuse -- Health aspects, Thrombosis -- Risk factors, Thrombolytic therapy -- Physiological aspects, Health, Health care industry
Abstract

PURPOSE: As cocaine abuse has become widespread, catastrophic cocaine-associated cardiovascular events have been noted with increasing frequency. Although these incidents are thought to be caused by drug-induced vasoconstriction and/or arterial thrombosis, the influence of cocaine on the plasma constituents involved in endogenous thrombosis and thrombolysis has not been characterized. PATIENTS AND METHODS: In 22 patients (8 men, 14 women, ages 32 to 62 years) undergoing cardiac catheterization, blood samples were procured before and 15 minutes after the administration intranasal saline (n = 8, controls) or cocaine, 2 mg/kg (n = 14), and the plasma concentrations of fibrinogen, plasminogen, and lipoprotein(a), as well as tissue plasminogen activator activity and plasminogen activator inhibitor (PAI-1) activity, were measured. RESULTS: No variable changed with the use of intranasal saline, whereas the use of cocaine resulted in an increase in PAI-I activity (0.48 + 0.06 (mean + SD] nmol\L at baseline, 0.53 + 0.05 nmol/L after cocaine, P = 0.011). CONCLUSION: Intranasal cocaine administration is associated with an increase in plasma PAI-1 activity. This may be important in recreational users of cocaine who experience vascular thrombosis.

Published
1994

180. Coronary anatomy and prognosis of young, asymptomatic survivors of myocardial infarction

Author

Negus, Brian H., Willard, John E., Glamann, D. Brent, Landau, Charles, Snyder, Richard W., Hillis, L. David, and Lange, Richard A.

Subjects
Heart attack -- Prognosis, Coronary heart disease -- Prognosis, Health, Health care industry
Abstract

PURPOSE: To assess the coronary anatomy and prognosis of young, asymptomatic survivors of myocardial infarction. PATIENTS AND METHODS: The records Of all 5,316 patients who underwent cardiac catheterization at Parkland Memorial Hospital from July 1978 to December 1992 were reviewed to identify those patients 40 years old and younger who were catheterized within 60 days of a first myocardial infarction. Of 129 such patients, 48 had no indication for catheterization other than age (group I), and 81 were catheterized for spontaneous or provocable ischemia (group II). Extent of coronary artery disease and long-term follow-up were examined to ascertain the utility of cardiac catheterization in the asymptomatic patients. Results: The 2 groups were similar with respect to clinical variables. The asymptomatic survivors of infarction (group I) had fewer diseased coronary arteries than did those with post-infarction ischemia (group II) (1.0 [+ or -] 0.7 versus 1.5 [+ or -] 1.0 [mean + or -] SD] diseased coronary arteries, respectively; P = 0.002) and were less likely to have left-main or 3-vessel coronary artery disease (4% versus 20%, respectively; P = 0.027). Eight-three percent of the group I patients had one diseased coronary artery, or less, and no patient underwent angioplasty or coronary bypass grafting on the basis of catheterization. After 71 [+ or -] 44 months of follow-up, only 5 (10%) had died of a coronary-related event. CONCLUSIONS: Asymptomatic survivors of myocardial infarction who are 40 years of age or less rarely have left-main or 3-vessel coronary artery disease, and their long-term prognosis with conservative therapy is good. Routine catheterization in these patients is not warranted and should be reserved for those who manifest spontaneous or provocable post-infarction ischemia.

Published
1994

181. Alleviation of cocaine-induced coronary vasoconstriction with intravenous verapamil

Author

Negus, Brian H., Willard, John E., Hillis, L. David, Glamann, D. Brent, Landau, Charles, Snyder, Richard W., and Lange, Richard A.

Subjects
Cocaine -- Usage, Vasoconstriction -- Causes of, Verapamil -- Evaluation, Heart, Health
Abstract

Cocaine use has been associated with a number of cardiovascular complications, including angina pectoris, myocardial infarction and sudden cardiac death.[1-4] Previous studies in humans have shown that cocaine causes epicardial coronary vasoconstriction, which is mediated, at least in part, by [alpha]-adrenergic stimulation.[5-10] Studies in experimental animals have suggested that cocaine may also cause vasoconstriction by altering calcium transport in vascular smooth muscle,[11] and this can be attenuated by calcium channel blockade. The present study was performed to assess the effect of verapamil, a calcium antagonist, on cocaine-induced coronary vaso-constriction in humans.

Published
1994

182. Frequency, cause and effect on operative outcome of depressed left ventricular ejection fraction in mitral stenosis

Author

Snyder, Richard W., II, Lange, Richard A., Willard, John E., Glamann, D. Brent, Landau, Charles, Negus, Brian H., and Hillis, L. David

Subjects
Mitral valve stenosis, Heart ventricle, Left -- Physiological aspects, Health
Abstract

To assess the incidence, pathophysiology and influence on operative outcome of a depressed left ventricular (LV) ejection fraction (EF) in patients with mitral stenosis (MS), demographic, hemodynamic and cineangiographic data on 72 patients (16 men, 56 women, aged 19 to 75 years) with isolated MS were reviewed. Of the 45 who had mitral commissurotomy or replacement, operative course and functional class before and after surgery were assessed. Of the 72 patients, 21 (29%) had an LVEF [is less than or equal to]0.50. These 21 were similar to the 51 with an LVEF >0.50 in age, gender, heart rate, intracardiac pressures, transvalvular gradient and valve area, but they had larger LV end-diastolic (79 [+ or -] 19 [mean [+ or -] SD] vs 59 [+ or -] 15 ml/[m.sup.2], p 0.50. (Am J Cardiol 1994;73:65-69)

Published
1994

183. Transmyocardial laser revascularization

Author

Downing, Stephen W., Williams, Simon G., Wright, David J., Tan, Lip Bun, Frazier, O.H., March, Robert J., Horvath, Keith A., Allen, Keith B., Lange, Richard A., and Hillis, L. David

Subjects
Myocardial revascularization -- Methods, Lasers in surgery -- Usage
Published
2000

187. Hydrogen inhalation for detecting intracardiac left-to-right shunting in adults

Author

Glamann, D. Brent, Lange, Richard A., Willard, John E., Landau, Charles, and Hillis, L. David

Subjects
Hydrogen, Heart -- Abnormalities, Cardiac catheterization -- Methods, Health
Abstract

The hydrogen inhalation technique is easily performed and exquisitely sensitive for detecting intracardiac left-to-right shunting. Previous studies of this technique relied heavily on data from infants and children, and the distinction between 'normal' and 'abnormal' was imprecise and somewhat arbitrary. The present study was done to assess the results of hydrogen inhalation in adults with and without intracardiac left-to-right shunting. In 45 adult subjects (15 men, 30 women, aged 18 to 72 years) (18 without and 27 with intracardiac left-to-right shunting), the elapsed time from hydrogen inhalation to its appearance in the pulmonary artery was measured. The 18 patients without shunting had an appearance time of 12 [+ or -] 3 (mean [+ or -] SD) seconds, and it was [greater than or equal to]9 seconds in all. In contrast, the 27 subjects with shunting had an appearance time of 1.5 [+ or -] 0.7 second, with only 1 of 27 being [greater than or equal to]3 seconds. There was no relation between the magnitude of left-to-right shunting and the hydrogen appearance time. Thus, the hydrogen inhalation technique easily and reliably separates adult subjects with and without intracardiac left-to-right shunting, with no overlap between the 2 groups.

Published
1993

192. Effect of coronary angioplasty on late potentials one to two weeks after acute myocardial infarction

Author

Boehrer, James D., Glamann, D. Brent, Lange, Richard A., Willard, John E., Brogan, Walter C., III, Eichhorn, Eric J., Grayburn, Paul A., Anwar, Azam, and Hillis, L. David

Subjects
Heart attack -- Prognosis, Transluminal angioplasty -- Usage, Health
Abstract

In survivors of acute myocardial infarction (AMI), the restoration of anterograde flow in the infarct artery, even if accomplished beyond the time for myocardial salvage, may reduce the frequency of subsequent arrhythmic events and sudden death. Twelve subjects (8 men and 4 women, aged 39 to 69 years) with a first AMI, signal-averaged electrocardiographic late potentials, and an occluded infarct artery were prospectively identified. Seven (group I) had successful coronary angioplasty 6 to 15 days after AMI, and 5 (group II) were managed conservatively. Follow-up signal-averaged electrocardiography was performed 3 to 7 months later. From baseline to follow-up, the 7 group I subjects had a significant change in QRS duration (117 [+ or -] 13 [mean + SD] to 102 [+ or -] 10 ms), root-mean-square voltage (10.4 [+ or -] 4.7 to 31.0 [+ or -] 7.6 [Micro]V), and low-amplitude signal duration (47.5 [+ or -] 8.5 to 32.4 [+ or -] 5.2 ms) (p [less than or equal to]0.05 for all 3 variables). No group I patient had a late potential at follow-up. In contrast, the 5 group II patients showed no change in QRS duration or low-amplitude signal duration from baseline to follow-up, and all 5 had a late potential at follow-up. At follow-up, the root-mean-square voltage was significantly greater and the low-amplitude signal and QRS durations significantly less in group I than in group II (p (Am J Cardiol 1992;70:1515-1519)

Published
1992

194. Comparison of single and biplane ventriculography for determination of left ventricular volume and ejection fraction

Author

Brogan, Walter C., III, Glamann, D. Brent, Lange, Richard A., and Hillis L. David

Subjects
Cineangiography, Heart ventricle, Left -- Physiological aspects, Heart beat -- Measurement, Health
Abstract

This study was done to compare single and biplane left ventriculography in quantitating left ventricular (LV) volumes and ejection fraction. LV volumes and ejection fraction were measured from a 30 [degrees] right anterior oblique single plane ventriculogram and a 30 [degrees] right anterior oblique 60 [degrees] left anterior oblique biplane ventriculogram in 152 men (aged 59 [+ or -] 9 [mean [+ or -] standard deviation] years), of whom 102 had hypokinesia, akinesia, or dyskinesia. There was excellent agreement between the results of single and biplane ventriculography with respect to LV end-diastolic volume (r = 0.96), end-systolic volume (r = 0.98) and ejection fraction (r = 0.97). The end-diastolic and end-systolic volumes measured by biplane ventriculography were consistently slightly larger than those measured by single plane, whereas ejection fractions measured by the 2 techniques were remarkably similar, even for the 46 patients with biplane ejection fractions

Published
1992

195. Utility of various radionuclide techniques for distinguishing ischemic from nonischemic dilated cardiomyopathy

Author

Glamann, D. Brent, Lange, Richard A., Corbett, James R., and Hillis, L. David

Subjects
Cardiomyopathy, Dilated -- Diagnosis, Radioisotope scanning, Exercise tests, Health
Abstract

* Background. - Clinically, ischemic and nonischmeic (idiopathic) dilated cardiomyopathy may be difficult to distinguish. Radionuclide ventriculography and exercise testing with thallium-201 scintigraphy are often used in attempt to differentiate them noninvasively. With these techniques, the presence of (1) left ventricular (LV) regional asynergy, (2) depressed LV systolic function with normal right ventricular function, and/or (3) thallium-201 perfusion abnormalities traditionally has been regarded as evidence of ischemic heart disease. We assessed the incidence with which these abnormalities occur in patients with nonischemic-dilated cardiomyopathy. Methods. - Seventy-six patients (45 men, 31 women, aged 18 to 74 years) with invasively proven nonischemic-dilated cardiomyopathy underwent radionuclide ventriculography (n = 75) and provocative thallium-2011 perfusion imaging (n = 17). Results. - Regional LV wall abnormalities were noted in 48% of patients, and 54% had LV systolic dysfunction without concomitant right ventricular dysfunction. Reversible and/or fixed exercise-induced thallium-2011 perfusion abnormalities occurred in 94% of the patients studied. Conclusions. - Radionuclide ventriculography and exercise testing with thallium perfusion imaging cannot be used reliably to differentiate ischemic from nonischemic dilated cardiomyopathy, since many patients with the latter have radionuclide evidence of LV segmental wall motion selective LV systolic dysfunction, and segmental perfusion abnormalities. (Arch Intern Med. 1992; 152;769-772)

Published
1992

196. Colaboradores

Author

Abrams, Charles S., Adler, Ronald S., Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allos, Ban Mishu, Anderson, Jeffrey L., Angus, Derek C., Appel, Gerald B., Appelbaum, Frederick R., Armitage, James O., Armstrong, Deborah K., Arnaout, M. Amin, Arnold, Robert M., Atkins, David, Atkinson, John P., Ayanian, John Z., Baddour, Larry M., Bagby, Grover C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Bangham, Charles R.M., Barasch, Jonathan, Barbano, Richard L., Barrett, Bruce, Bartholomew, John R., Bartleson, J.D., Barton, Mary, Basner, Robert C., Bass, Anne R., Baum, Stephen G., Bauman, Julie E., Bausch, Daniel G., Bayer, Arnold S., Bazari, Hasan, Bazarian, Jeffrey J., Beigel, John H., Bel, Elisabeth H., Beller, George A., Berger, Joseph R., Berk, Paul D., Berliner, Nancy, Bernat, James L., Bierman, Philip J., Biesecker, Leslie G., Bishop, Michael R., Biundo, Joseph J., Blankson, Joel N., Blattner, William A., Bleck, Thomas P., Bloch, Karen C., Blom, Henk J., Bodamer, Olaf A., Boden, William E., Boivin, Guy, Bolognia, Jean, Bonnez, William, Bonomo, Robert A., Booth, Sarah L., Bosque, Patrick J., Breakwell, Lucy, Brenner, David J., Brochard, Laurent, Brook, Itzhak, Brunetti, Enrico, Bryant, Amy E., Buchner, David M., Buffet, Pierre A., Bushinsky, David A., Bykerk, Vivian P., Byrd, John C., Calabresi, Peter A., Calfee, David P., Camaschella, Clara, Camilleri, Michael, Cappellini, Maria Domenica, Carabello, Blase A., Carvalho, Edgar M., Catherino, William H., Cauley, Jane A., Chalasani, Naga P., Chambers, Henry F., Chang, Larry W., Chen, Lin H., Chen, Sharon C.-A., Cheshire, William P., Jr., Chockalingam, Arun, Christiani, David C., Chu, Edward, Cieslak, Theodore J., Cioffi, George A., Clancy, Carolyn M., Clauss, Heather E., Clauw, Daniel J., Clemmons, David R., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Cohn, Steven L., Connors, Joseph M., Cook, Deborah J., Cooper, David S., Craft, Joseph, Crandall, Jill P., Croft, Simon L., Crow, Mary K., Crump, John A., Cudkowicz, Merit E., Cullen, Mark R., Cunningham-Rundles, Charlotte, Damon, Inger K., Daniels, Troy E., Dart, Richard, Davidson, Nancy E., DeAngelis, Lisa M., DeCamp, Malcolm M., Del Rio, Carlos, DeLuca, Gabriele C., Denning, David W., Deuster, Patricia A., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Doroshow, James. H., Douglas, John M., Jr., Drazen, Jeffrey M., Drekonja, Dimitri, Dreskin, Stephen C., Drew, W. Lawrence, Drusano, George L., DuBose, Thomas D., Jr., Dumler, J. Stephen, DuPont, Herbert L., Duvic, Madeleine, Edwards, Kathryn M., Edwards, N. Lawrence, Einhorn, Lawrence H., Eliopoulos, George M., Elliott, Perry M., Ellner, Jerrold J., Emanuel, Ezekiel J., Ernst, Joel D., Everson, Gregory T., Evoli, Amelia, Falagas, Matthew E., Falk, Gary W., Fang, James C., Feder, Gene, Feller-Kopman, David J., File, Thomas McDonald, Jr., Firestein, Gary S., Fishman, Glenn I., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Forsmark, Chris E., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Franco, Manuel A., Freedman, David O., French, Martyn A., Freund, Karen M., Galgiani, John N., Gallagher, Patrick G., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., George, Tony P., Gepstein, Lior, Gerber, Susan I., Gerding, Dale N., Gertz, Morie A., Ghanem, Khalil G., Gill, Christopher J., Ginsberg, Jeffrey S., Ginsburg, Geoffrey S., Glesby, Marshall J., Gnann, John W., Jr., Golden, Matthew R., Goldman, David L., Goldman, Lee, Goldstein, Larry B., Gore, Richard M., Gotlib, Jason, Gotuzzo, Eduardo, Grammer, Leslie C., Grasemann, Hartmut, Grayson, M. Lindsay, Greenberg, Harry B., Greenberg, Steven A., Greer, David M., Griggs, Robert C., Grinberg, Lev M., Grossman, Daniel, Guay-Woodford, Lisa M., Gulick, Roy M., Gupta, Rajesh, Hadigan, Colleen, Hagman, Melissa M., Hagspiel, Klaus D., Handsfield, H. Hunter, Harris, Raymond C., Hayden, Frederick G., Hecht, Frederick M., Heimburger, Douglas C., Hensrud, Donald D., Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillyer, Christopher D., Hoit, Brian D., Holland, Steven M., Hollenberg, Steven M., Hook, Edward W., III, Howard, Jo, Hunter, David J., Hussain, Khalid, Iannuzzi, Michael C., Inman, Robert D., Inouye, Sharon K., Ison, Michael G., Jacobson, Karen R., Jaff, Michael R., Jen, Joanna C., Jensen, Dennis M., Jensen, Michael D., Jensen, Robert T., Joffe, Alain, Johnson, Stuart, Jones, Robin L., Jones, Sian, Jonklaas, Jacqueline, Jordan, Richard C., Kahi, Charles J., Kamya, Moses R., Kao, Louise W., Kaplan, Steven A., Kastner, Daniel L., Katzka, David A., Katzman, Debra K., Kauffman, Carol A., Kaushansky, Kenneth, Kaye, Keith S., Keating, Armand, Kelley, Robin K., Kern, Morton J., Keusch, Gerald T., Khuri, Fadlo R., Kirchhoff, Louis V., Kirtane, Ajay J., Klion, Amy D., Knopman, David S., Ko, Christine J., Kontoyiannis, Dimitrios P., Koppel, Barbara S., Korenblat, Kevin M., Korf, Bruce R., Kortepeter, Mark G., Kottilil, Shyamasundaran, Kovacs, Joseph A., Kovacs, Thomas O., Kowdley, Kris V., Kraft, Monica, Kramer, Christopher M., Krasnewich, Donna M., Kratz, Alexander, Kraus, Virginia Byers, Kraus, William E., Krause, Peter J., Kroshinsky, Daniela, Kuemmerle, John F., Kuipers, Ernst J., Laheru, Daniel, Landry, Donald W., Lang, Anthony E., Lange, Richard A., Lederle, Frank A., Lee, William M., Leggett, James E., Levine, Glenn N., Levine, Marc S., Levine, Stephanie M., Lichtenstein, Gary R., Liebmann, Jeffrey M., Lim, Henry W., Lima, Aldo A.M., Lin, Geoffrey S.F., Link, Mark S., Lloyd-Jones, Donald M., Lorber, Bennett, Louie, Arnold, Lucey, Daniel R., Lyness, Jeffrey M., MacKenzie, C. Ronald, MacMillan, Harriet L., Madoff, Robert D., Maldarelli, Frank, Malhotra, Atul, Manary, Mark J., Manu, Peter, Marcos, Luis A., Marelli, Ariane J., Mariette, Xavier, Marks, Andrew R., Marr, Kieren A., Marrie, Thomas J., Martin, Paul, Martinez, Fernando J., Mason, Joel B., Masur, Henry, Mathers, Amy J., Matteson, Eric L., Matthay, Michael A., Mayer, Emeran A., Mayer, Stephan A., McCool, F. Dennis, McInnes, Iain, McKenna, William J., McLaughlin, Vallerie, McMurray, John J.V., McQuaid, Kenneth R., Mead, Paul S., Means, Robert T., Jr., Meintjes, Graeme, Melton-Meaux, Genevieve B., Merrick, Samuel T., Michel, Marc, Mink, Jonathan W., Mitch, William E., Molitoris, Bruce A., Montoya, José G., Moy, Ernest, Mukherjee, Debabrata, Murr, Andrew H., Musher, Daniel M., Myerburg, Robert J., Nadeau, Kari C., Naides, Stanley J., Nash, Theodore E., Nath, Avindra, Neal-Perry, Genevieve, Neff, Anne T., Neilson, Eric G., Nelson, Christina A., Nelson, Lewis S., Nestler, Eric J., Newman, Anne B., Nicolle, Lindsay E., Nieman, Lynnette K., Nocturne, Gaetane, O’Connor, Christopher M., O’Connor, Francis G., O’Connor, Patrick G., O’Dell, James R., O’Donnell, Anne E., Oh, Jae K., Okhuysen, Pablo C., Okun, Michael S., Olgin, Jeffrey E., Olsen, Nancy J., Orenstein, Walter A., O’Shea, John J., Osmon, Douglas R., Otto, Catherine M., Ottolini, Martin G., Pappas, Peter G., Park, Ben Ho, Pasricha, Pankaj Jay, Patel, Manisha, Patel, Robin, Paterson, David L., Pawlotsky, Jean-Michel, Payne, Thomas H., Pearson, Richard D., Perl, Trish M., Pesce, Michael A., Petersen, Brett W., Petri, William A., Jr., Pfeffer, Marc A., Pisetsky, David S., Powell, Frank, Pyeritz, Reed E., Quinn, Thomas C., Radhakrishnan, Jai, Radich, Jerald, Rafailidis, Petros I., Raghu, Ganesh, Ragni, Margaret V., Raja, Srinivasa N., Rajkumar, S. Vincent, Ralston, James D., Ralston, Stuart H., Raoult, Didier, Ratner, Adam J., Reboli, Annette C., Reddy, K. Rajender, Redelmeier, Donald A., Reef, Susan E., Reilly, John, Reller, Megan E., Resnick, Neil M., Reuben, David B., Robinson, Jennifer G., Rogatsky, Inez, Rogers, Joseph G., Rolain, Jean-Marc, Rollins, Barrett J., Romero, José R., Rosene-Montella, Karen, Rosenthal, Philip J., Russell, James A., Rustgi, Anil K., Rusyniak, Daniel E., Sakoulas, George, Salata, Robert A., Salmon, Jane E., Salvana, Edsel Maurice T., Santoro, Nanette, Santos, Renato M., Santucci, Peter A., Savard, Patrice, Sawka, Michael N., Scanlon, Paul D., Schafer, Andrew I., Schaffner, William, Scheld, W. Michael, Schiff, Manuel, Schilsky, Michael L., Schooley, Robert T., Schriger, David L., Schuchter, Lynn M., Schulman, Sam, Schwartz, Lawrence B., Seas, Carlos, Seifert, Steven A., Seifter, Julian Lawrence, Selcen, Duygu, Semrad, Carol E., Shamoon, Harry, Shaw, Pamela J., Shaz, Beth H., Sheridan, Robert L., Sherman, Stuart, Shieh, Wun-Ju, Shy, Michael E., Sidransky, Ellen, Siegel, Richard M., Sifri, Costi D., Siliciano, Robert F., Simberkoff, Michael S., Simel, David L., Skorecki, Karl, Slutsky, Arthur S., Small, Eric J., Smetana, Gerald W., Smith, Gordon, Southwick, Frederick S., Spiegel, Allen M., Spiera, Robert, Spinola, Stanley M., Stabler, Sally P., Stanford, Stephanie M., Stark, Paul, Steensma, David P., Steiner, Theodore S., Stephens, David S., Stevens, David A., Stevens, Dennis L., Stoller, James K., Stone, John H., Stone, Richard M., Strikas, Raymond A., Su, Edwin P., Sutter, Roland W., Swerdloff, Ronald S., Swygard, Heidi, Sykes, Megan, Talbot, H. Keipp, Tanofsky-Kraff, Marian, Tarlo, Susan M., Teirstein, Paul S., Telford, Sam R., III, Thakker, Rajesh V., Therrien, Judith, Thompson, George R., III, Tosti, Antonella, Trehan, Indi, Turner, Ronald B., Valeri, Anthony Michael, Varga, John, Vaughn, Bradley V., Venook, Alan P., Verbalis, Joseph G., Victor, Ronald G., Vincent, Angela, Vincent, Tonia L., Wachter, Robert M., Wagner, Edward H., Walsh, Edward E., Walsh, Thomas J., Walston, Jeremy D., Walter, Roland B., Wang, Christina, Ware, Lorraine B., Warren, Cirle A., Watson, John T., Weber, Thomas J., Weinberg, Geoffrey A., Weinstein, David A., Weinstein, Robert S., Weiss, Roger D., Weiss, Roy E., Weitz, Jeffrey I., Wenzel, Richard P., Werth, Victoria P., West, Sterling G., White, A. Clinton, Jr., White, Christopher J., White, Julian, White, Perrin C., Whitley, Richard J., Whyte, Michael P., Wiebe, Samuel, Wiener-Kronish, Jeanine P., Wilber, David J., Winikoff, Beverly, Winter, Jane N., Wolin, Edward M., Wormser, Gary P., Young, Neal S., Young, Vincent B., Young, William F., Jr., Yu, Alan S.L., Zaidi, Anita K.M., Zaki, Sherif, Ziegler, Thomas R., and Zimetbaum, Peter

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2021
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198. Contributors

Author

Abad, Kashif, Abdul-Hussein, Mustafa, Adam, Rodney D., Adams, Paul C., Agudelo Higuita, Nelson Iván, Akst, Lee, Anderson, Kelley P., Andre, Paul, Anstead, Gregory M., Aring, Ann M., Arshi, Arash, Avalos, Danny, Azar, Cecilio M., Azarbal, Amir, Baeseman, Zachary J., Bailey, Justin, Bajaj, Mandeep, Bakhutashvili, Vladimer, Balagué, Federico, Barth, Bradley E., Basello, Gina M., Bassaly, Renee M., Bassily-Marcus, Adel, Baughn, Julie M., Beard, Sheryl, Belakovskiy, Aleksandr, Ben-Ami, Ronen, Bencheqroun, Hassan, Bernstein, David I., Bernstein, Jonathan A., Biggerstaff, Kristin Schmid, Birt, Mitchell, Bloomfield, Clara, Blum, William, Bolotin, Diana, Bonnema, Rachel A., Borenstein, David, Bossart, Christopher, Bragg, Dee Ann, Bragg, Scott, Bremjit, Prasheda, Brice, Sylvia L., Brill, John, Brown, Patricia D., Brown, Patrick, Brown, Rachel, Buckley, Peter F., Burns, Sarah, Byrd, Kenneth, Cadavid, Diego, Caraccio, Thomas R., Carek, Peter J., Carrion, Andres F., Cass, Amanda S., Castell, Donald O., Catinella, Anthony Peter, Cayley, William E., Jr., Cerquozzi, Sonia, Cervera, Alvaro, Chamberlain, Rachel, Chan, Lawrence, Chan, Miriam, Chang, Zenas, Chen, Jimmy, Chen, Lin Yee, Chihara, Shingo, Chitlur, Meera, Chohan, Saima, Christensen, Jacob, Chyu, Kuang-Yuh, Cigarroa, Joaquin E., Cleland, Paul, Cline, Matthew K., Coates, Laura C., Colenbrander, August, Collins, Tracie C., Commins, Ryan M., Conageski, Christine, Conly, John M., Contini, Carlo, Cooper, Ashley, Cormier, Allison K., Corriveau, Michael L., Cox, Bart L., Cunha, Burke A., Cunha, Cheston B., Curry, Amy E., Dai, Julia, Daines, Cori L., Damas, Oriana M., Damitz, Beth A., Dattilo, Natalie C., Davaro, Raul, David, Kevin A., de Leon, André, de Leon, Tate, DeCastro, Alexei O., DeGeorge, Katharine C., DeLoughery, Thomas G., Deodhar, Atul, Desai, Urmi, Dessinioti, Clio, Diamond, Michael P., Donnan, Geoffrey A., Dorsch, John N., Douglas, Chad, Dowler, Shannon, Drevets, Douglas A., Dudley, Samuel C., Jr., Duggan, Peter R., Eagle, Kim, Eck, Leigh M., Egnatios, Genevieve L., Atrouni, Wissam El, Elston, Dirk M., Embil, John M., Epstein, Scott K., Evans, Susan, Evens, Andrew M., Fagan, J. Barry, Faris, Anna, Faugno, Anthony J., III, Fayssoux, Kinder, Feldman, Dorianne, Fife, Terry D., Finley, David J., Firnhaber, Jonathon, Fisher, William E., Fleseriu, Maria, Fletcher, Donald C., Forsberg, Sarah, Foster, Jeffrey Michael, Frank, Jennifer, Freeman, Ellen W., Gaba, Ruchi, Gaines, Melissa, Ghany, Marc G., Ghazi, Muhammad Ahmad, Gibney, Geoffrey, Gilbert, Donald L., Gilchrist, Karissa, Gillaspie, Erin A., Gilotra, Tarvinder, Gladwin, Mark T., Gluckman, Stephen J., Goddard, Andrew W., Goerl, Kyle, Gold, Mark S., Goldstein, Joshua N., González-Fernández, Marlis, Goodwin, Gregory, Gosmanov, Aidar R., Gradoni, Luigi, Graham, Timothy P., Grant-Kels, Jane M., Grdinovac, Kristine, Greenberg, Leslie A., Greene, William M., Greensher, Joseph, Gregory, David S., Greiwe, Justin, Gumbo, Tawanda, Hague, Melissa, Halder, Rebat M., Hall, Alan M., Hall, Ronald, II, Harman, Lynn E., Harris, Kari R., Harrison, Taylor B., Hartman, Adam L., Haynes, James W., Heidelbaugh, Joel J., Hinderliter, Stacey A., Hinshaw, Molly A., Hockenberry, Brandon, Hohl, Raymond J., Holguin, Therese, Holstein, Sarah A., Holyoak, Michael, Homan, Gretchen, Hommema, Kevin, Hommema, Laurie A.M., Horn, Leora, Hossani-Madani, Ahmad Reza, House, Steven A., Houssayni, Sarah, Hueston, William J., Huffstetler, Alison N., Hundahl, Scott A., Hunger, Stephen P., Irwin, Gretchen M., Isaac, Daniel, Isenberg, Gerald A., Jackson, Alan C., Jacobson, Kurt M., Jaller, Jose A., James, W. Ennis, Jia, Xiaoming, Johnson, Casey R., Johnson, Lisa M., Jolissaint, Joshua S., Juckett, R. Gregory, Judson, Marc A., Kadhiravan, Tamilarasu, Kalia, Rachna, Rachel Kanter, Jessica, Karnad, Dilip R., Karnchanasorn, Rudruidee, Katsambas, Andreas, Katz, Ben Z., Katzman, Rebecca, Kaufer, Daniel I., Kaunitz, Andrew M., Keegan, B. Mark, Kellerman, Rick D., Kellermann, Scott, Kelly, Christina M., Khaki, Sheevaun, Kim, Arthur Y., Kim, Haejin, Kirsner, Robert S., Kiwalkar, Sonam, Kolb, Amanda, Kolla, Bhanu Prakash, Korley, Frederick K., Kovalsky, Adrienne N., Krause, Megan, Kraut, Eric H., Krishnamurti, Lakshmanan, Krishnan, Kumar, Kuhlmann, Zachary, Kulkarni, Roshni, Kumar, Seema, Kwaan, Mary R., Kyle, Robert A., Lampton, Lucius Marion, Lange, Richard A., Langlois, Fabienne, Larkin, Jerome, Lau, Christine L., Lawrence-Hylland, Susan, Lee, Lydia U., Leikin, Jerrold B., Leikin, Scott, Leung, Alexander K.C., LeWinter, Martin M., Lewis, Jennifer, Li, Ming, Liebenstein, Tyler K., Lin, Albert P., Lin, Kevin, Lindemann, Janet C., Linder, Jeffrey A., Lock, James, Long, M. Chantel, Loo-Gross, Colleen, Malhotra, Uma, Manlove, Emily, Manson, JoAnn E., Mansukhani, Meghna P., Marcocci, Claudio, Margo, Curtis E., Marker, Jason E., Martin, Paul, Matson, Kristine, Matza, Mark A., Maxwell, Pinckney J., IV, May, Danica, Mazepa, Marshall, McGrew, Christopher, McGuigan, Christopher C., McGuigan, Michael, Meiselman, Mick S., Mercado, Moises, Merrell, Ryan, Meyers, Steven L., Miller, Brian J., Millington, Timothy M., Mirza, Moben, Mishra, Kriti, Mofenson, Howard C., Mogensen, Kris M., Morgenthaler, Timothy I., Moritz, Michael L., Mortada, Rami, Moser, Scott E., Moss, Heather E., Moul, Judd W., Mullen, Heidi E.K., Murinova, Natalia, Murphy, Michael, Mutasim, Diya F., Muthusubramanian, Arjun, Nagji, Alykhan S., Nazeef, Moniba, Neelakantan, Viswanathan K., Neff, Donald A., Neil, Tara J., Nelson, William G., Neschis, David G., Nester, Theresa, Nguyen, Tam T., Nicol, Andrea L., Nieves-Arriba, Lucybeth, Novac, Andrei, Novelli, Enrico M., Nye, Lauren, Obi, Andrea T., Okeson, Jeffrey P., Oliveira, Carlos R., Ong, Peck Y., Oram, Daniel S., Overturf, Gary D., Ozgonenel, Bulent, Pacak, Karel, Padin-Rosado, José A., Padungkiatsagul, Tanyatuth, Paladine, Heather L., Pandolfino, John E., Pasipanodya, Jotam, Passarella, Pasquale, Patel, Deval, Patton, Simon, Penna, Gerson Oliveira, Penna, Maria Lucia Fernandes, Perkins, Allen, Peterson, Leah, Petroianu, Georg A., Petronic-Rosic, Vesna M., Phan, Hanna, Pietroni, Mark, Pollart, Susan M., de Andrade Pontes, Maria Araci, Porter, Andrew S.T., Powell, Charles R., Pusateri, Margaret, Quinn, James M., Rahko, Peter S., Rajkumar, S. Vincent, Rakel, David P., Ramakrishnan, Kalyanakrishnan, Ramirez, Julio A., Rana, Jatin, Rank, Matthew A., Raoult, Didier, Rapose, Alwyn, Ravindran, Anita Devi K., Reddy, Elizabeth, Reid, Ian R., Rennert-May, Elissa, Rew, Karl T., Rezapour, Mona, Rhyne, Amanda, Riese, Martha, Robbins, David C., Robertson, Amy, Robinson, Malcolm K., Roche, William P., Rohrberg, Tessa E., Rose, Candice, Rose, Peter G., Rosenthal, Richard N., Ross, Stephen, Roth, Alan R., Ruha, Anne-Michelle, Rundell, Kristen, de Sá Gonçalves, Heitor, Said, Adnan, Sairenji, Tomoko, Samson, Susan L., Sanchez, Carlos E., Sangodkar, Sandeep, Santana, Arelis, Sarode, Ravi, Schatz, Michael, Schevchuck, Alex, Schiller, Lawrence R., Schoessow, Kim, Schrager, Sarina, Schuller, Dan, Seery, Amy, Seifert, Steven A., Semel, Jeffery D., Shaffi, Saeed Kamran, Shah, Beejal, Shah, Prediman K., Shah, Samir S., Shah, Shenil, Shammo, Jamile M., Shapiro, Eugene D., Sharara, Ala I., Sheehan, John P., Sherman, Kamille S., Shew, Sable, Sievers, Karlynn, Silk, Hugh, Simon, Lisa, Sinclair, Aaron D., Siraj, Dawd S., Sloane, Philip D., Smith, Zachary L., Sojka, John, Somers, William J., Song, Mihae, Sosa, Nestor, Sowder, Timothy, Speer, Linda, Spencer, Abby L., Stephens, Todd, St. Louis, Erik Kent, Stratakis, Constantine A., Stulberg, Daniel, Suárez, José Antonio, Takashima, Masayoshi, Takyar, Varun, Talhari, Carolina, Tang, Jie, Tate, Jessica, Templeton, Kim, Teng, Joyce M.C., Thomson, Joanna, Thrasher, J. Brantley, Tillett, William, Tobin, Kenneth, Tsaltas, Theodore T., Unizony, Sebastian H., Unruh, Mark, Uppendahl, Locke, Vallurupalli, Anusha, Van Buren, George, II, van Duin, David, Van Durme, Daniel J., Varlamov, Elena V., Vélez, Christopher, Vercellotti, Gregory, Vincent, Kyle, Vinh, Donald C., Vyas, Jatin M., Wagner, Tamara, Wakefield, Thomas W., Wald, Arnold, Wald, Ellen R., Walker, Robin A., Wall, Barry M., Wang, Andrew, Wang, Ernest, Wang, Jennifer, Watanabe, Koji, Weber, Ruth, Wehler, Cheryl, Wei, Alice C., Weida, Jane A., Weissman, David N., Welliver, Robert C., Sr., Wester, Rebecca M., Westergaard, Ryan P., Wexler, Randell, Whitley, Brian M., Wilamowska, Katarzyna, Williams, Kimberly, Williams, Tracy L., Winterhoff, Boris, Wipperman, Jennifer, Wittler, Robert, Wolf, Katherine I., Wood, Gary S., Worswick, Scott, Wu, Steve W., Wyre, Hadley, Yakubov, Steven J., Yang, Xinghong, Yew, Kenneth S., Yi, Yooni, Yiannias, James A., and Young, Natawadee

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2021
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