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613 results on '"Lam, Yat Yin"'

151. Screening for ventriculo-aortic functional disturbances in patients with apparently successful repaired coarctation of aorta.

Author

Lam, Yat-Yin, Henein, Michael Y, Lam, Yat-Yin, and Henein, Michael Y

Abstract

Patients with apparently successful repair for coarctation of aorta have reduced life expectancy irrespective of the occurrence of recoarctation, biscupid aortic valvular complications or systemic hypertension. The increasingly recognized ventriculo-aortic functional disturbances (subendocardial ischemia and central aortic stiffness) that persist after operation may contribute to the known significant cardiovascular mortality and morbidity. Echocardiography and cardiac magnetic resonance imaging allow earlier identification of these high-risk features in patients may thus guide towards optimum therapy.

Published
2010
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154. Right ventricular stunning in inferior myocardial infarction.

Author

Ramzy, Ihab S, O'Sullivan, Christine A, Lam, Yat-Yin, Dancy, Mark, Tei, Chuwa, Henein, Michael Y, Ramzy, Ihab S, O'Sullivan, Christine A, Lam, Yat-Yin, Dancy, Mark, Tei, Chuwa, and Henein, Michael Y

Abstract

AIM: To assess right ventricular (RV) function in patients with inferior myocardial infarction (IMI) and to observe changes following thrombolysis. BACKGROUND: RV dysfunction occurs in 30% of patients with IMI. The extent of such involvement and its potential, recovery has not been determined. METHODS: We studied 30 patients with acute IMI (age 56+/-12 years), on admission, day 7 and day 30 post thrombolysis. No patient had clinical signs of RV failure. RV segmental function was assessed from free wall long axis and global function from filling and ejection velocities. Values were compared with 15 age-matched controls. RESULTS: On admission, RV long axis amplitude, systolic and diastolic velocities were depressed (2.09+/-0.39 vs 2.6+/-0.3 cm, 8.18+/-1.8 vs 10.0+/-2.0 cm/s and 6.9+/-2.7 vs 10.0+/-2.5 cm/s, p<0.01 for all) and global function impaired; reduced Z ratio (0.85+/-0.07 vs 0.9+/-0.04, p<0.01), raised Tei index (0.49+/-0.26 vs 0.3+/-0.1, p<0.001) and prolonged t-IVT (8.16+/-3.9 vs 4.8+/-2 s/m, p<0.01) compared to controls. After thrombolysis, RV long axis amplitude (2.28+/-0.3 cm, p<0.05), systolic velocity (10.0+/-2.7 cm/s, p<0.01), early diastolic velocity (8.3+/-2.16, p<0.05), Z ratio (0.9+/-0.05, p<0.01), Tei index (0.34+/-0.17, p<0.01) and t-IVT (6.2+/-2.7 s/m, p<0.05) all normalised at day 30. Only 4 (13%) patients remained with RV long axis amplitude and one with t-IVT and Tei index values outside the normal 95% CI at day 30. RV inflow diameter and tricuspid regurgitation did not change. CONCLUSION: In IMI, RV segmental and global functions are acutely impaired, and recover in 87% of patients following thrombolysis. In the absence of clear evidence for RV infarction the disturbances in the remaining 13% may represent stunned myocardium that may demonstrate delayed recovery.

Published
2008
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155. Relation Between Serum Total Bilirubin Levels and Severity of Coronary Artery Disease in Patients With Non-ST-Segment Elevation Myocardial Infarction

Author

Kaya, Mehmet Gungor, primary, Sahin, Omer, additional, Akpek, Mahmut, additional, Duran, Mustafa, additional, Uysal, Onur Kadir, additional, Karadavut, Serhat, additional, Cosgun, M. Said, additional, Savas, Goktug, additional, Baktir, Ahmet Oguz, additional, Sarli, Bahadir, additional, and Lam, Yat Yin, additional

Published
2013
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161. Cost-effectiveness analysis of left atrial appendage occlusion compared with pharmacological strategies for stroke prevention in atrial fibrillation.

Author

Vivian Wing-Yan Lee, Ronald Bing-Ching Tsai, Ines Hang-Iao Chow, Bryan Ping-Yen Yan, Kaya, Mehmet Gungor, Park, Jai-Wun, Yat-Yin Lam, Lee, Vivian Wing-Yan, Tsai, Ronald Bing-Ching, Chow, Ines Hang-Iao, Yan, Bryan Ping-Yen, and Lam, Yat-Yin

Subjects
MITRAL valve diseases, STROKE prevention, ATRIAL fibrillation, COST effectiveness, QUALITY of life, ATRIAL fibrillation treatment, HEART atrium, DECISION making, CARDIAC surgery, MYOCARDIAL depressants, STROKE, QUALITY-adjusted life years, STATISTICAL models, DISEASE complications, ECONOMICS, SURGERY, THERAPEUTICS
Abstract

Background: Transcatheter left atrial appendage occlusion (LAAO) is a promising therapy for stroke prophylaxis in non-valvular atrial fibrillation (NVAF) but its cost-effectiveness remains understudied. This study evaluated the cost-effectiveness of LAAO for stroke prophylaxis in NVAF.Methods: A Markov decision analytic model was used to compare the cost-effectiveness of LAAO with 7 pharmacological strategies: aspirin alone, clopidogrel plus aspirin, warfarin, dabigatran 110 mg, dabigatran 150 mg, apixaban, and rivaroxaban. Outcome measures included quality-adjusted life years (QALYs), lifetime costs and incremental cost-effectiveness ratios (ICERs). Base-case data were derived from ACTIVE, RE-LY, ARISTOTLE, ROCKET-AF, PROTECT-AF and PREVAIL trials. One-way sensitivity analysis varied by CHADS2 score, HAS-BLED score, time horizons, and LAAO costs; and probabilistic sensitivity analysis using 10,000 Monte Carlo simulations was conducted to assess parameter uncertainty.Results: LAAO was considered cost-effective compared with aspirin, clopidogrel plus aspirin, and warfarin, with ICER of US$5,115, $2,447, and $6,298 per QALY gained, respectively. LAAO was dominant (i.e. less costly but more effective) compared to other strategies. Sensitivity analysis demonstrated favorable ICERs of LAAO against other strategies in varied CHADS2 score, HAS-BLED score, time horizons (5 to 15 years) and LAAO costs. LAAO was cost-effective in 86.24 % of 10,000 simulations using a threshold of US$50,000/QALY.Conclusions: Transcatheter LAAO is cost-effective for prevention of stroke in NVAF compared with 7 pharmacological strategies. The transcatheter left atrial appendage occlusion (LAAO) is considered cost-effective against the standard 7 oral pharmacological strategies including acetylsalicylic acid (ASA) alone, clopidogrel plus ASA, warfarin, dabigatran 110 mg, dabigatran 150 mg, apixaban, and rivaroxaban for stroke prophylaxis in non-valvular atrial fibrillation management. [ABSTRACT FROM AUTHOR]

Published
2016
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191. Correction: Clinical outcomes of bicuspid versus tricuspid aortic valve stenosis after transcatheter aortic valve replacement with self‑expandable valves.

Author

Jin, Qinchun, Chen, Shasha, Yang, Xue, Li, Mingfei, Li, Wei, Zhang, Xiaochun, Zhou, Daxin, Lam, Yat-Yin, and Ge, Junbo

Subjects
HEART valve prosthesis implantation, AORTIC stenosis, TRICUSPID valve, BICUSPIDS, TREATMENT effectiveness
Abstract

Qinchun Jin, Shasha Chen and Xue Yang contributed equally to this work. Correction: Clinical outcomes of bicuspid versus tricuspid aortic valve stenosis after transcatheter aortic valve replacement with self-expandable valves SP 2 sp Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. [Extracted from the article]

Published
2023
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197. Comparison of angiotensin-converting enzyme inhibitor alone and in combination with irbesartan for the treatment of heart failure

Author

Kum, Leo Chi-Chiu, primary, Yip, Gabriel Wai-Kwok, additional, Lee, Pui-Wai, additional, Lam, Yat-Yin, additional, Wu, Eugene B., additional, Chan, Anna Kin-Yin, additional, Fung, Jeffrey Wing-Hong, additional, Chan, Joseph Yat-Sun, additional, Zhang, Qing, additional, Kong, Shun-Ling, additional, and Yu, Cheuk-Man, additional

Published
2008
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199. Aldosterone Receptor Antagonism Induces Reverse Remodeling When Added to Angiotensin Receptor Blockade in Chronic Heart Failure

Author

Chan, Anna K.Y., primary, Sanderson, John E., additional, Wang, Tian, additional, Lam, Wynnie, additional, Yip, Gabriel, additional, Wang, Mei, additional, Lam, Yat-Yin, additional, Zhang, Yan, additional, Yeung, Leata, additional, Wu, Eugene B., additional, Chan, Wilson W.M., additional, Wong, John T.H., additional, So, Nina, additional, and Yu, Cheuk-Man, additional

Published
2007
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