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The primary function of a network system is to gather information from the observation region and transmit it to the base station. The network life span and congestion are the two major concerns in wireless networks. To enhance the lifespan of the sensor system; multi-hopping has been proved as best in class. Congestion is an important factor to be taken, where multiple nodes forward data to one another in the process of communication. Hence to overcome the issue of congestion in WSN, we proposed a congestion detection and mitigation method along with the multi-hop concept. In this technique, we have considered different routes among communication units that were classified on distance, relative attainment rate (RAR) and node storage occupancy. A utility function (U) has been proposed and calculated using the above illustrated factors for every node that acts as a neighbour to the transmitting node. The Neighbour node with the highest U-valued will be considered as the packet forwarding node's next hop. In this manner, congestion-free nodes are selected for data transmission. [ABSTRACT FROM AUTHOR]

Efficiency of the battery pack largely depends on the resistive losses and heat generation between the interconnections of the battery cells. Grouping of battery cells usually is done in different ways in industries. However, losses vary depending on applications or states of electric vehicle (EV). Therefore, it is necessary to determine the efficiency and heat generation in battery cells as well as battery packs. In practical situations, some battery cells are charged rapidly in comparison to other battery cells. On the other hand, when an EV is in running condition some battery cells are discharged rapidly. As a results battery pack cannot provide better efficiency and its life span is reduced. As an alternative option the inter-cell connection of battery package is needed to reconfigure in an optimized way. In this paper firstly, a battery pack with switches is modeled and then efficiency and temperature variation with respect to time are determined. Then, an experimental setup is investigated to measure the efficiency and temperature rise with respect to time. Results, explained in the paper, demonstrate that battery pack with switches increases the efficiency if it is measured after switching (97–98 %), while temperature increases from 25 °C to 50 °C for different C-rates. [ABSTRACT FROM AUTHOR]

This work aimed to investigate the lifespan and breeding use, reproductive qualities, and the level of their discreteness in sows of the large white breed of French breeding, considering their operational value. Agroprime Holding LLC of the Odesa region, the laboratory of innovative technologies, and experimental livestock facilities of the Institute of Pig Breeding and AIP of the National Academy of Sciences carried out the practical part of the work. Evaluation of sows according to indicators characterizing the level of their adaptation and reproductive qualities was carried out taking into account the following characteristics: life expectancy, days; duration of tribal use, days; received farts; all live piglets were born, head.; multifertility, ch.; high fertility, kg.; nest weight at the time of weaning at 28 days, kg; preservation, %. The selection index of reproductive qualities of the sow (SIRQS) was calculated according to the method of O. M. Tsereniuk et al. (2010), the coefficient of discreteness (D) - Seromolot and Sviatchenko (1984). Biometric processing of research results was carried out according to generally accepted methods. It has been established that sows of the large white breed of French breeding, provided they are kept in production premises using innovative technologies, are characterized by high indicators of the level of adaptation and reproductive qualities. Thus, their life span is 905.7 days, the duration of breeding use is 680.6 days, and in terms of reproductive qualities, they belong to the elite class. A significant difference between the groups of experimental animals was established in terms of life expectancy, duration of breeding use, total number of live piglets, multifertility, and litter weight at the time of weaning at the age of 28 days. The maximum indicators of high fertility (1.34 kg) and preservation of piglets until weaning at the age of 28 days (100 %) were found in sows of the "low operational value" category. The coefficient of discreteness of life expectancy and breeding use in sows of I, II, and III experimental groups is equal to 0.406, 0.677, and 0.633, reproductive qualities - 0.828, 0.882, and 0.903, respectively. Coefficients of paired correlation between life span and breeding use of sows and signs of reproductive qualities range from -0.055 to +0.904. The maximum increase in additional production was obtained from sows of the "high operational value" category - +6.80 %, and its value is +355.57 UAH/head/farrowing. [ABSTRACT FROM AUTHOR]

Analysts’ observable careers are short. Around half of the analysts we study have observable lives of approximately three years. Using the IBES database as a proxy for the length of analysts’ careers, we find that distraction and herding shorten observable lives. There are important roles for economically rational influences. The length of observable careers is reduced by inaccuracy in forecasting. Issuing a first forecast early but, on average, delaying forecasts for the portfolio of firms they cover also increase analysts’ life spans. We find no robust association between life span and optimism or overconfidence. [ABSTRACT FROM AUTHOR]

Purpose: This paper aims to investigate the effect of physical vapor deposition (PVD)-coated stencil wall aperture on the life span of fine-pitch stencil printing. Design/methodology/approach: The fine-pitch stencil used in this work is fabricated by electroform process and subsequently nano-coated using the PVD process. Stencil printing process was then performed to print the solder paste onto the printed circuit board (PCB) pad. The solder paste release was observed by solder paste inspection (SPI) and analyzed qualitatively and quantitatively. The printing cycle of up to 80,000 cycles was used to investigate the life span of stencil printing. Findings: The finding shows that the performance of stencil printing in terms of solder printing quality is highly dependent on the surface roughness of the stencil aperture. PVD-coated stencil aperture can prolong the life span of stencil printing with an acceptable performance rate of about 60%. Originality/value: Stencil printing is one of the important processes in surface mount technology to apply solder paste on the PCB. The stencil's life span greatly depends on the type of solder paste, stencil printing cycles involved and stencil conditions such as the shape of the aperture, size and thickness of the stencil. This study will provide valuable insight into the relationship between the coated stencil wall aperture via PVD process on the life span of fine-pitch stencil printing. [ABSTRACT FROM AUTHOR]

This study examines the effect of top managers' team age diversity on firm performance and the moderation effect of top managers' average age on the top manager's age diversity and firm performance. The study used quantitative data from 63 listed firms on East African stock exchanges. It used hierarchical linear modeling to test the hypotheses. Results indicated that the main effect of top managers' team age diversity is statistically significant and positively related to firm performance as measured by ROA. Furthermore, the moderation effect of top managers' average age is statistically significant but negatively moderates the relationship between top managers' age diversity and firm performance. The study theoretically contributed to upper-echelon literature by introducing other theories-- the information and decision-making theory, and the socioemotional theory that collaborates with upper-echelon literature to explain the effect of top managers' age diversity on firm performance as moderated by the average age of top managers. The innovation of this study comes from extended knowledge of the micro-contextual factor, which has been used to moderate this relationship. [ABSTRACT FROM AUTHOR]

Smilax china L. (Chinaroot) is a natural herb that has multiple uses, such as being used to make tea and food. Both its roots and leaves have different uses due to their unique components. In this study, we analyzed the extract of S. china. roots using LC-HRMS and evaluated the neuroprotective effects and metabolic regulation of S. china on Caenorhabditis elegans. Chinaroot extract prolonged the life span of healthy nematodes, delayed the paralysis time of transgenic CL4176, and reduced the level of β-amyloid deposition in transgenic CL2006. The comprehensive analysis of metabolomics and qRT-PCR revealed that Chinaroot extract exerted neuroprotective effects through the valine, leucine and isoleucine degradation and fatty acid degradation pathways. Moreover, we first discovered that the expressions of T09B4.8, ech-7, and agxt-1 were linked to the neuroprotective effects of Chinaroot. The material exerted neuroprotective effects by modulating metabolic abnormalities in AD model C. elegans. Our study provides a new foundation for the development of functional food properties and functions. [ABSTRACT FROM AUTHOR]

In this paper we study wave breaking in the unidirectional non-local wave model describing the motion of a collision-free plasma in a magnetic field. By analyzing the monotonicity and continuity properties of a system of the Riccati-type differential inequalities involving the extremal slopes of flows, we show a new sufficient condition on the initial data to exhibit wave breaking. Moreover, the estimates of life span and wave breaking rate are derived. [ABSTRACT FROM AUTHOR]

Mating and receipt of male Sex Peptide hormone cause increased egg laying, increased midgut size and decreased life span in female Drosophila. Feeding mated females with the synthetic steroid mifepristone decreases egg production, reduces midgut size, and increases life span. Here, several gene mutations were assayed to investigate possible mechanisms for mifepristone action. Drosophila Dhr96 is a hormone receptor, and a key positive regulator of midgut lipid uptake and metabolism. Dhr96[1] null mutation increased female life span, and reduced the effects of mifepristone on life span, suggesting that Dhr96[1] mutation and mifepristone may act in part through the same mechanism. Consistent with this idea, lipidomics analysis revealed that mating increases whole-body levels of triglycerides and fatty-acids in triglycerides, and these changes are reversed by mifepristone. Maternal tudor[1] mutation results in females that lack the germ-line and produce no eggs. Maternal tudor[1] mutation increased mated female life span, and reduced but did not eliminate the effects of mating and mifepristone on life span. This indicates that decreased egg production may be related to the life span benefits of mifepristone, but is not essential. Mifepristone increases life span in w[1118] mutant mated females, but did not increase life span in w[1118] mutant virgin females. Mifepristone decreased egg production in w[1118] mutant virgin females, indicating that decreased egg production is not sufficient for mifepristone to increase life span. Mifepristone increases life span in virgin females of some, but not all, white[+] and mini-white[+] strains. Backcrossing of mini-white[+] transgenes into the w[1118] background was not sufficient to confer a life span response to mifepristone in virgin females. Taken together, the data support the hypothesis that mechanisms for mifepristone life span increase involve reduced lipid uptake and/or metabolism, and suggest that mifepristone may increase life span in mated females and virgin females through partly different mechanisms. [ABSTRACT FROM AUTHOR]

In this work, zinc oxide–based piezoelectric nanogenerator (PENG) over the flexible Kapton polyimide (PI) substrate is developed. The device performance is improved by laser texturing of PI substrate, which increases the effective surface area of PI and adhesivity of ZnO thin film with PI substrate to improve the reliability and life span of the device. The untextured PI‐based PENG generates a peak‐to‐peak output voltage, current, and power of 6 V, 420 nA, 2.42 μW, respectively, which increases to 15.8 V, 790 nA, and 12.51 μW, respectively, on using textured PI obtained by 60% laser spot overlap. On further increasing the laser spot overlap to 80%, the peak‐to‐peak output voltage, current, and power improve to 22.2 V, 1210 nA, and 26.88 μW, respectively. Therefore, as compared to the untextured‐PI‐based PENG, laser‐textured‐PI‐based PENG is a promising candidate for energy‐harvesting applications. [ABSTRACT FROM AUTHOR]

Several technologies provide cellular connectivity to transmit data to end devices (EDs) in the indoor environment. These technologies have short-range; complex network architecture; short lifespan; and high power consumption. In this paper, LoRa is utilized to design the Building Internet of Things (BIoT) system for electronic shelf labels (ESL) to provide long-range connectivity. To minify the transmission losses, the concurrent data exploits data parallelism for updating transmission parameters at the network server (NS) for non-interruptive communication between the centroid gateways (GWs) and allocated EDs. The EDs are deployed by K-means at different locations in each cluster based on spreading factor (SF) and data rate (DR) to avoid data congestion and intra-SF interference for the SF and hybrid (DR/SF) models. The varying bandwidths (BWs) and duty cycles (DCs) enhance the lifespan of the EDs, while the Bayesian game parameter selection (BGPS) method minimizes the power losses among the EDs. The one-slope estimates medium losses; the adjusted R-square predicts variance; and Pearson finds a correlation among the measured values. The hybrid model improves the network's performance to a spiraling average efficiency of 90.48 % and 89.64 %, with network saturation of 10.185 % and 10.337 % for pure and slotted ALOHA, respectively. The overall results illustrate a packet loss ratio (PLR) of 20.11 % for the SF model and 4.861 % for the hybrid model. The energy dissipation plunged to 0.06032 J per day, prolonging the EDs' life span to 14265.34 days. [ABSTRACT FROM AUTHOR]

Thermal performance curves (TPCs) are increasingly used as a convenient approach to predict climate change impacts on ectotherms that accounts for organismal thermal sensitivity; however, directly applying TPCs to temperature data to estimate fitness has yielded contrasting predictions depending on assumptions regarding climate variability. We compare direct application of TPCs to an approach integrating TPCs for different fitness components (e.g., per capita birth rate, adult life span) across ectotherm life cycles into a population dynamic model, which we independently validated with census data and applied to hemipteran insect populations across latitude. The population model predicted that climate change will reduce insect fitness more at higher latitudes due to its effects on survival but will reduce net reproductive rate more at lower latitudes due to its effects on fecundity. Directly applying TPCs underestimated climate change impacts on fitness relative to incorporating the TPCs into the population model due to simplifying survival dynamics across the life cycle. The population model predicted that climate change will reduce mean insect density and increase population variability at higher latitudes via reduced survival, despite faster development and a longer activity period. Our study highlights the importance of considering how multiple fitness components respond to climate variability across the life cycle to better understand and anticipate the ecological consequence of climate change. [ABSTRACT FROM AUTHOR]

Women's capacity to reproduce varies over the life span, and developmental goals such as family formation are age-graded and shaped by social norms about the appropriate age for completing specific developmental tasks. Thus, a woman's age may be linked to her ideas about what an ideal partner should be like. With the goals of replicating and extending prior research, in this study we examined the role of age in women's partner preferences across the globe. We investigated associations of age with ideal long-term partner preferences in a cross-cultural sample of 17,254 single (i.e., unpartnered) heterosexual women, ages 18 to 67, from 147 countries. Data were collected via an online questionnaire, the Ideal Partner Survey. Confirming our preregistered hypotheses, we found no or only negligible age effects on preferences for kindness-supportiveness, attractiveness, financial security-successfulness, or education-intelligence. Age was, however, positively associated with preferences for confidence-assertiveness. Consistent with family formation goals, age was associated with an ideal partner's parenting intentions (high until approximately age 30, then decreasing afterward). Age range deemed acceptable (and in particular, the discrepancy between one's own age and the minimum ideal age of a partner) increased with age. This latter pattern also replicated in exploratory analyses based on subsamples of lesbian and bisexual women. In summary, age has a limited impact on partner preferences. Of the attributes investigated, only preference for confidence-assertiveness was linked with age. However, age range deemed acceptable and an ideal partner's parenting intention, a dimension mostly neglected in earlier research, substantially vary with age. [ABSTRACT FROM AUTHOR]

Cell Competition emerged in Drosophila as an unexpected phenomenon, when confronted clones of fit vs unfit cells genetically induced. During the last decade, it has been shown that this mechanism is physiologically active in Drosophila and higher organisms. In Drosophila, Flower (Fwe) eliminates unfit cells during development, regeneration and disease states. Furthermore, studies suggest that Fwe signaling is required to eliminate accumulated unfit cells during adulthood extending Drosophila lifespan. Indeed, ahuizotl (azot) mutants accumulate unfit cells during adulthood and after physical insults in the brain and other epithelial tissues, showing a decrease in organismal lifespan. On the contrary, flies carrying three functional copies of the gene, unfit cell culling seems to be more efficient and show an increase in lifespan. During aging, Azot is required for the elimination of unfit cells, however, the specific organs modulating organismal lifespan by Azot remain unknown. Here we found a potential connection between gut-specific Azot expression and lifespan which may uncover a more widespread organ-specific mechanism modulating organismal survival. [ABSTRACT FROM AUTHOR]

Significance: A cell plays its roles throughout its life span, even during its demise. Regulated cell death (RCD) is one of the key topics in modern biomedical studies. It is considered the main approach for removing stressed and/or damaged cells. Research during the past two decades revealed more roles of RCD, such as coordinating tissue development and driving compensatory proliferation during tissue repair. Recent Advances: Compensatory proliferation, initially identified in primitive organisms during the regeneration of lost tissue, is an evolutionarily conserved process that also functions in mammals. Among various types of RCD, apoptosis is considered the top candidate to induce compensatory proliferation in damaged tissue. Critical Issues: The roles of apoptosis in the recovery of nonregenerative tissue are still vague. The roles of other types of RCD, such as necroptosis and ferroptosis, have not been well characterized in the context of tissue regeneration. Future Directions: In this review article, we attempt to summarize the recent insights on the role of RCD in tissue repair. We focus on apoptosis, with expansion to ferroptosis and necroptosis, in primitive organisms with significant regenerative capacity as well as common mammalian research models. After gathering hints from regenerative tissue, in the second half of the review, we take a notoriously nonregenerative tissue, the myocardium, as an example to discuss the role of RCD in terminally differentiated quiescent cells. Antioxid. Redox Signal. 39, 1053–1069. [ABSTRACT FROM AUTHOR]

In this review we provide an overview of functional traits for freshwater communities, including macrophytes, periphyton, phytoplankton, fish, macroinvertebrates, and more thoroughly testate amoebae, rotifers, cladocerans, and copepods. Our approach provides a synopsis of functional traits of these groups, which is emerging as a valuable tool in evaluating environmental changes and anthropogenic influences. For the zooplankton community gathering information on traits remains a work in progress. Employing a standardized schema when selecting functional traits across zooplankton groups is a non-optional task; this is especially the case for rotifers because to their diversity of forms and feeding strategies. The role of microcrustaceans in trophic chains has highlighted importance of traits for this group, thus providing clues to their ecosystem effects. Here we aim at providing a framework for functional trait selection in aquatic communities prioritizing life strategies in resources acquisition, habitat preference, and life span and reproduction. Notwithstanding, the assembly of a framework of traits remains in progress and with it, is the taking shape of multiple and varying functions and services that the diverse communities are constantly providing within freshwater ecosystems. [ABSTRACT FROM AUTHOR]

Objective: Personality traits change in both mean levels and variance across the life span but the mechanisms underlying these developmental trends remain unclear. Social Investment Principle (SIP) suggests that social expectations drive personality changes in adulthood. Accordingly, we tested whether differences between personality traits in social expectations for them can explain their different change trajectories in young adulthood. Methods: A pool of 257 personality items was used to measure personality traits' means and variances (N = 1096), and levels expected by friends, partners and bosses/supervisors (N = 121). Results: Raters were consistent in their expectations for how young adults should think, feel and behave. Traits under stronger expectations had higher mean levels and lower variances than traits under lower expectations; trait means and variances increased with age, but inconsistently with the SIP, these increases were unrelated to the traits' expected levels. Conclusion: Our results are only partially consistent with the SIP. [ABSTRACT FROM AUTHOR]

We define aging as a characteristic deterioration in one (or more) observable attributes of an organism that typically occurs during later life. With this narrow functional definition, we gain the freedom to separate aging from other processes of age-related change (e.g., maturation, growth, illness, terminal decline). We introduce a structural model that distinguishes between (1) the phenomenon of aging, (2) the subjective experience of aging, (3) sources of aging, and (4) consequences of aging. A core focus of the model is on the role of buffering mechanisms of biological repair and personal adaptation that regulate the relations between sources of aging, aging proper, and its consequences. The quality and level of functioning of these buffering mechanisms also varies across the life span, which directly affects the sources of aging, resulting in either resilience against or accelerated aging, and thus can be considered to be a major source of the variation in aging processes among different individuals. External factors comprising attributes of the physical environment and sociocultural characteristics are considered as contexts in which aging occurs. These contextual factors are assumed to feed into the various components of the model. Our model provides an interdisciplinary account of human aging, its sources and consequences, and also its subjective experience, by integrating biological, psychological, lifestyle, and sociocultural factors, and by specifying their interrelations and interactions. The model provides a comprehensive understanding of individual human aging, its underlying processes, and modulating factors. It allows for the derivation of empirically testable hypotheses, and it helps practitioners to identify elements that lend themselves to targeted intervention efforts aimed at increasing the resilience of individuals against aging and buffering its negative consequences. [ABSTRACT FROM AUTHOR]

Due to the repeated cycles of charging and discharging, battery manufacturers cannot ensure perfect cell balance. Cell balancing is considered essential for equalizing each battery cell to the same state of charge level in a series configuration. Lithium-ion (Li-ion) batteries can be damaged or have their lifespan decreased by improper discharge processes. This study investigates battery balance during discharge by analyzing the state of charge (SoC) and current distribution of a 3-cell battery pack based on a multi-transformer shared flyback converter (F-C) under varying load conditions. A balanced approach is employed to control individual cells using a dedicated switch for each cell during the discharge process. The results indicate that the proposed active balancing method can enhance the Li-ion pack's balancing capacity while reducing the disparity in residual energy among the battery cells. The unique contribution of this research lies in the active balancing approach, which offers efficient and effective battery management during discharge. This approach provides crucial insights for the future development of improved battery systems. Therefore, Given the linearly decreasing target SoC, the average error over all time points is approximately 4.29%. [ABSTRACT FROM AUTHOR]

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Since its discovery, much attention has been drawn to irisin's potential role in metabolic and reproductive diseases. This narrative review summarizes and updates the possible role played by this fascinating molecule in different physiological (puberty and menopause) and pathological (polycystic ovary syndrome (PCOS), functional hypothalamic amenorrhea (FHA), endometriosis, and gestational diabetes) conditions that can affect women throughout their entire lives. Irisin appears to be an important factor for the hypothalamic–pituitary–gonadal axis activation, and appears to play a role in the timing of puberty onset. Serum irisin levels have been proposed as a biomarker for predicting the future development of gestational diabetes (GDM). Its role in PCOS is still controversial, although an "irisin resistance" mechanism has been hypothesized. In addition to its impact on metabolism, irisin also appears to influence bone health. Irisin levels are inversely correlated with the prevalence of fractures in postmenopausal women. Similar mechanisms have also been postulated in young women with FHA. In clinical settings, further controlled, prospective and randomized clinical trials are needed to investigate the casual relationship between irisin levels and the conditions described and, in turn, to establish the role of irisin as a prognostic/diagnostic biomarker or a therapeutic target. [ABSTRACT FROM AUTHOR]

Highlights: This review discusses the potential of degradable metallic micromotors for a variety of biomedical and environmental applications. The design principles, fabrication techniques and degradation mechanisms of degradable metallic micromotors are reviewed in detail. Challenges and future directions for the development of degradable metallic micromotors for real-life applications are presented. Synthetic micromotor has gained substantial attention in biomedicine and environmental remediation. Metal-based degradable micromotor composed of magnesium (Mg), zinc (Zn), and iron (Fe) have promise due to their nontoxic fuel-free propulsion, favorable biocompatibility, and safe excretion of degradation products Recent advances in degradable metallic micromotor have shown their fast movement in complex biological media, efficient cargo delivery and favorable biocompatibility. A noteworthy number of degradable metal-based micromotors employ bubble propulsion, utilizing water as fuel to generate hydrogen bubbles. This novel feature has projected degradable metallic micromotors for active in vivo drug delivery applications. In addition, understanding the degradation mechanism of these micromotors is also a key parameter for their design and performance. Its propulsion efficiency and life span govern the overall performance of a degradable metallic micromotor. Here we review the design and recent advancements of metallic degradable micromotors. Furthermore, we describe the controlled degradation, efficient in vivo drug delivery, and built-in acid neutralization capabilities of degradable micromotors with versatile biomedical applications. Moreover, we discuss micromotors' efficacy in detecting and destroying environmental pollutants. Finally, we address the limitations and future research directions of degradable metallic micromotors. [ABSTRACT FROM AUTHOR]

Cardiometabolic risk is increasing in prevalence across the life span with disproportionate ramifications for youth at socioeconomic disadvantage. Established risk factors and associated disease progression are harder to reverse as they become entrenched over time; if current trends are unchecked, the consequences for individual and societal wellness will become untenable. Interrelated root causes of ectopic adiposity and insulin resistance are understood but identified late in the trajectory of systemic metabolic dysregulation when traditional cardiometabolic risk factors cross current diagnostic thresholds of disease. Thus, children at cardiometabolic risk are often exposed to suboptimal metabolism over years before they present with clinical symptoms, at which point life-long reliance on pharmacotherapy may only mitigate but not reverse the risk. Leading-edge indicators are needed to detect the earliest departure from healthy metabolism, so that targeted, primordial, and primary prevention of cardiometabolic risk is possible. Better understanding of biomarkers that reflect the earliest transitions to dysmetabolism, beginning in utero, ideally biomarkers that are also mechanistic/causal and modifiable, is critically needed. This scientific statement explores emerging biomarkers of cardiometabolic risk across rapidly evolving and interrelated "omic" fields of research (the epigenome, microbiome, metabolome, lipidome, and inflammasome). Connections in each domain to mitochondrial function are identified that may mediate the favorable responses of each of the omic biomarkers featured to a heart-healthy lifestyle, notably to nutritional interventions. Fuller implementation of evidence-based nutrition must address environmental and socioeconomic disparities that can either facilitate or impede response to therapy. [ABSTRACT FROM AUTHOR]

We have shown that multiple tRNA synthetase inhibitors can increase lifespan in both the nematode C. elegans and the budding yeast S. cerevisiae by acting through the conserved transcription factor Gcn4 (yeast)/ATF-4 (worms). To further understand the biology downstream from this conserved transcription factor in the yeast model system, we looked at two different yeast models known to have upregulated Gcn4 and GCN4-dependent increased replicative lifespan. These two models were rpl31aΔ yeast and yeast treated with the tRNA synthetase inhibitor borrelidin. We used both proteomic and RNAseq analysis of a block experimental design that included both of these models to identify GCN4-dependent changes in these two long-lived strains of yeast. Proteomic analysis of these yeast indicate that the long-lived yeast have increased abundances of proteins involved in amino acid biosynthesis. The RNAseq of these same yeast uncovered further regulation of protein degradation, identifying the differential expression of genes associated with autophagy and the ubiquitin–proteasome system (UPS). The data presented here further underscore the important role that GCN4 plays in the maintenance of protein homeostasis, which itself is an important hallmark of aging. In particular, the changes in autophagy and UPS-related gene expression that we have observed could also have wide-ranging implications for the understanding and treatment of diseases of aging that are associated with protein aggregation. [ABSTRACT FROM AUTHOR]

BACKGROUND In 2021, the American College of Medical Genetics and Genomics (ACMG) recomdemended reporting actionable genotypes in 73 genes associated with diseases for which preventive or therapeutic measures are available. Evaluations of the association of actionable genotypes in these genes with li fe span are currently lacking. METHODS We assessed the prevalence of coding and splice variants in genes on the ACMG Secondary Findings, version 3.0 (ACMG SF v3.0), list in the genomes of 57,933 Icelanders. We assigned pathogenicity to all reviewed variants using reported eviHeldence in the ClinVar database, the frequency of variants, and their associations with disease to create a manually curated set of actionable genotypes (variants). We assessed the relationship between these genotypes and life span and further examined the specific causes of death among carriers. RESULTS Through manual curation of 4405 sequence variants in the ACMG SF v3.0 genes, we identified 235 actionable genotypes in 53 genes. Of the 57,933 participants, 2306 (4.090) carried at least one actionable genotype. We found shorter median survival among persons carrying actionable genotypes than among tioncarriers. Specifically, we found that carrying an actionable genotype in a cancer gene was associated with survival that was 3 years shorter than that among noncarriers, with causes of death among carriers attributed primarily to cancer-related conditions. Furthermore, we found evidence of association between carrying an actionable genotype in certain genes in the cardiovascular disease group and a reduced life span. CONCLUSIONS On the basis of the ACMG SF v3.0 guidelines, we found thatt approximately 1 in 25 Icelanders carried an actionable genotype and that carrying such a genotype was associated with a reduced life span. (Funded by deCODE Genetics-Amgen. [ABSTRACT FROM AUTHOR]

Platelet ageing is an area of research which has gained much interest in recent years. Newly formed platelets, often referred to as reticulated platelets, young platelets or immature platelets, are defined as RNA-enriched and have long been thought to be hyper-reactive. This latter view is largely rooted in associations and observations in patient groups with shortened platelet half-lives who often present with increased proportions of newly formed platelets. Evidence from such groups suggests that an increased proportion of newly formed platelets is associated with an increased risk of thrombotic events and a reduced effectiveness of standard anti-platelet therapies. Whilst research has highlighted the existence of platelet subpopulations based on function, size and age within patient groups, the common intrinsic changes which occur as platelets age within the circulation are only just being explored. By understanding the changes that occur during the natural ageing processes of platelets, we may be able to identify the triggers for alterations in platelet life span and platelet reactivity. Here we review research on platelet ageing in the context of health and disease, paying particular attention to the experimental approaches taken and the robustness of conclusions that can be drawn. [ABSTRACT FROM AUTHOR]

Aging imaging is powerful to connect the mechanism research and the exploration of aging intervention, thus facilitating and optimizing the disease and health management Author contribution All authors contributed to the manuscript writing. Aging is a ubiquitous biological process that is accompanied by a progressive functional decline of various tissues and organs. Aging imaging is an emerging field to make the invisible aging processes visible, enabling the characterization of aging biology across the life span in vivo. Aging is a major worldwide challenge, and the aging hallmarks constitute important targets for studying aging and designing interventions. [Extracted from the article]

Parasites with complex life cycles often manipulate the phenotype of their intermediate hosts to increase the probability of transmission to their definitive hosts. Infection with Anomotaenia brevis, a cestode that uses Temnothorax nylanderi ants as intermediate hosts, leads to a multiple‐fold extension of host lifespan and to changes in behaviour, morphology and colouration. The mechanisms behind these changes are unknown, as is whether the increased longevity is achieved through parasite manipulation. Here, we demonstrate that the parasite releases proteins into its host with functions that might explain the observed changes. These parasitic proteins make up a substantial portion of the proteome of the hosts' haemolymph, and thioredoxin peroxidase and superoxide dismutase, two antioxidants, exhibited the highest abundances among them. The largest part of the secreted proteins could not be annotated, indicating they are either novel or severely altered during recent coevolution to function in host manipulation. We also detected shifts in the hosts' proteome with infection, in particular an overabundance of vitellogenin‐like A in infected ants, a protein that regulates division of labour in Temnothorax ants, which could explain the observed behavioural changes. Our results thus suggest two different strategies that might be employed by this parasite to manipulate its host: secreting proteins with immediate influence on the host's phenotype and altering the host's translational activity. Our findings highlight the intricate molecular interplay required to influence the phenotype of a host and point to potential signalling pathways and genes involved in parasite–host communication. [ABSTRACT FROM AUTHOR]

Aging is the consequence of intra- and extracellular events that promote cellular senescence. Dyskeratosis congenita (DC) is an example of a premature aging disorder caused by underlying telomere/telomerase-related mutations. Cells from these patients offer an opportunity to study telomere-related aging and senescence. Our previous work has found that telomere shortening stimulates DNA damage responses (DDRs) and increases reactive oxygen species (ROS), thereby promoting entry into senescence. This work also found that telomere elongation via TERT expression, the catalytic component of the telomere-elongating enzyme telomerase, or p53 shRNA could decrease ROS by disrupting this telomere--DDR--ROS pathway. To further characterize this pathway, we performed a CRISPR/Cas9 knockout screen to identify genes that extend life span in DC cells. Of the cellular clones isolated due to increased life span, 34% had a guide RNA (gRNA) targeting CEBPB, while gRNAs targeting WSB1, MED28, and p73 were observed multiple times. CEBPB is a transcription factor associated with activation of proinflammatory response genes suggesting that inflammation may be present in DC cells. The inflammatory response was investigated using RNA sequencing to compare DC and control cells. Expression of inflammatory genes was found to be significantly elevated (P < 0.0001) in addition to a key subset of these inflammation-related genes [IL1B, IL6, IL8, IL12A, CXCL1 (GROa), CXCL2 (GROb), and CXCL5]. which are regulated by CEBPB. Exogenous TERT expression led to downregulation of RNA/protein CEBPB expression and the inflammatory response genes suggesting a telomere length-dependent mechanism to regulate CEBPB. Furthermore, unlike exogenous TERT and p53 shRNA, CEBPB shRNA did not significantly decrease ROS suggesting that CEBPB's contribution in DC cells' senescence is ROS independent. Our findings demonstrate a key role for CEBPB in engaging senescence by mobilizing an inflammatory response within DC cells. [ABSTRACT FROM AUTHOR]

[Display omitted] Hypothesis : Aqueous zinc-ion batteries (AZIBs) have received considerable attention owing to their safety, low cost, and environmental benignity. However, the side reactions of hydrogen evolution revolution and Zn dendrite growth reduce the Coulombic efficiency and life span of AZIBs. To address these issues, we designed an artificial protective layer of a Te-hybridized core–shell zeolitic imidazolate framework (ZIF). Experiments : A core–shell structure of ZIF-8@ZIF-67 was first developed as a protecting layer on the Zn anode. To improve the poor conductivity of ZIF and its affinity for Zn, the core–shell structure was hybridized with zincophilic Te to increase the surface area and reduce the charge-transfer resistance. Findings : By incorporating metallic Te into ZIF-8 and ZIF-67, the nucleation potential and charge-transfer resistance were significantly reduced, enhancing the ion reaction kinetics and electron migration. Benefiting from the Te-hybridized ZIF-8@ZIF-67-derived nitrogen-doped porous carbon (Te-hybridized ZIF-8@ZIF-67/NC) layer, a full cell of Zn coated with Te-hybridized ZIF-8@ZIF-67/NC//MnO 2 exhibited an excellent rate performance of 214 mAh g−1 at an ultrahigh current density of 10 A g−1 and ultralong cycle life (3200 cycles) without the formation of Zn dendrites. [ABSTRACT FROM AUTHOR]

One of the key goals in studying the molecular and genetic basis of many pathologies is to find triggers that could positively influence the incidence of age-dependent diseases and the rate of aging in general. A possible cause of age-dependent degradation of the body's functions inducing aging is immunosenescence. It is known that the increased activity of mobile elements observed with age may not only affect the level of genome stability but also play a crucial role in the development of immune response. At the same time, the pivotal role of the nervous system in controlling life span has long been proven, and recently it has been shown that components of the machinery that regulate mobile elements activity do function in the nervous system, and their functioning affects the development of neurodegenerative diseases. This mini-review presents evidence for complex aging regulation by the nervous and immune systems involving systems that control activity of mobile elements and proposes a hypothetical scheme for their joint impact on life span. [ABSTRACT FROM AUTHOR]

Polyamines (PAs) are important molecules that determine cell longevity or death. Studies have shown that nutritional supplementation with spermidine can reduce age-related pathology and increase life span in a number of organisms, including humans. In addition, applying PAs to plants prevents their senescence. This review aims to provide an integrated understanding of the regulation of PA metabolism and its effect(s) on cell homeostasis. PA metabolism is universal for plants and animals. Research has shown that increased levels of PA synthesizing enzymes are associated with cell proliferation, whereas activation of the PA catabolic pathway increases oxidative stress and leads to aging/senescence due to cellular damage. Intracellular PA levels are regulated at the transcriptional and translational levels of the PA metabolic genes. The cis-acting regulatory elements and transcription factors determine the tissue-, developmental stage-, and stress-specific expression of a gene. At the translational level, it is regulated by miRNAs targeting mRNAs for cleavage or translational suppression. The byproducts of PA metabolism, such as hypusine and acrolein, are important for cell survival or death. PAs and their metabolic enzymes play several other important roles in plant and animal physiology via their effects on chromatin condensation, histone acetylation, histone deacetylation, transmethylation, and protein-protein interactions. This review focuses on the role(s) of PAs as universal bioregulators in processes across kingdoms, with specific reference to regulation of cellular longevity and death. [ABSTRACT FROM AUTHOR]

Background: Breeding objectives are designed to achieve targeted dairy cow production goals, which can be affected by production type, farmer preferences, environmental factors and genetic factors individually or in combination. Breeding practices, such as both controlled and uncontrolled, and artificial insemination (AI) are the tools used to obtain the desired breeding objectives. The lower reproductive performance of indigenous dairy cows affects the total milk production and calf crops that are produced during their lifetime. Designing appropriate breeding objectives and breeding practices can improve the reproductive performance of dairy cows and their overall production performance. Materials and methods: The current study was conducted with the objective of evaluating the breeding, practices and performance of indigenous dairy cattle in the south western part of Ethiopia. The districts of Gesha and Chena were purposefully chosen. The study design for the 384 household surveys was a cross‐sectional survey with a simple random sample approach. Data analysis was carried out by MS‐Excel (2010) and the general linear model procedure of SAS of 2008. Results: The current study revealed that methods of breeding were predominantly natural‐controlled mating, followed by natural‐uncontrolled mating and AI in descending order. Breeding objectives were input function, output function, sociocultural and economic functions and assets and security functions in decreasing order of rank. Reproduction performance indexes of indigenous dairy cows age at first service (3.72 ± 0.05 years), age at first calving (AFC) (4.71 ± 0.07 years), calving interval (CI) (1.58 ± 0.03 years), days open (DO) (4.26 ± 0.11 months), services per conception in natural mating (1.4 ± 0.08) and AI (2.73 ± 0.14), age of bull at maturity (4.17 ± 0.74 years), interoestrus interval (23.18 ± 0.61 days), calves crop (7.53 ± 0.22) and the life span of indigenous dairy cow (11.94 ± 0.26 years) were significant (p < 0.01) between two districts, whereas the values of age of bull at maturity and number of services per conception in natural mating were significant (p < 0.05) between districts. Conclusions: Using AI and major reproduction performances, such as AFC, CI and DO of indigenous dairy cows in the study area, were very low. Therefore, concerned bodies should intervene to improve reproduction performance through the utilization of AI techniques, with the integration of forage development activities and improvements in livestock health care. [ABSTRACT FROM AUTHOR]

The influential Whitehall studies found that top‐ranking civil servants in Britain experienced lower mortality than civil servants below them in the organizational hierarchy due to differential exposure to workplace stress. I test for a Whitehall effect in the United States using a 1930 cohort of white‐collar employees at a leading firm – General Electric (GE). All had access to a corporate health and welfare program during a critical period associated with the health transition. I measure status using position in the managerial hierarchy, attendance at prestigious management training camps and promotions, none of which is associated with a Whitehall‐like rank‐mortality gradient. Instead, senior managers and executives experienced a 3–5‐year decrease in lifespan relative to those in lower levels, with the largest mortality penalty experienced by individuals in the second level of the hierarchy. I discuss generalizability and potential explanations for this reversal of the Whitehall phenomenon using additional data on the status and lifespan of top business executives and US senators. [ABSTRACT FROM AUTHOR]

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Interferon beta (IFN beta) preparations are an established group of drugs used for immunomodulation in patients with multiple sclerosis (MS). Subcutaneously (sc) applied interferon beta-1a (IFN beta-1a sc) has been in continuous clinical use for 25 years as a disease-modifying treatment. Based on data published since 2018, we discuss recent insights from analyses of the pivotal trial PRISMS and its long-term extension as well as from newer randomized studies with IFN beta-1a sc as the reference treatment, the use of IFN beta-1a sc across the patient life span and as a bridging therapy, recent data regarding the mechanisms of action, and potential benefits of IFN beta-1a sc regarding vaccine responses. IFN beta-1a sc paved the way to effective immunomodulatory treatment of MS, enabled meaningful insights into the disease process, and remains a valid therapeutic option in selected vulnerable MS patient groups. [ABSTRACT FROM AUTHOR]

Owing to the high specific capacity and cost-effectiveness, cobalt-free high-nickel cathode materials (LiNixMn1−xO2, x > 0.5) are widely used in lithium-ion batteries for various electronic equipment and energy storage systems. However, their unsatisfactory electrochemical performance and relatively high cost still limit the large-scale application of LiNixMn1−xO2 cathodes. Herein, we propose a series of blended LiNi0.6Mn0.4O2(NM64)/LiMn2O4(LMO) cathode materials synthesized by a simple mechanical mixing method to significantly reduce the cathode material cost, as well as to ameliorate the cycling life span and rate ability. It is demonstrated that this feasible and economic blending strategy fully exploits the advantages of high-specific-capacity NM64 with a layered structure and low-cost LMO with a spinel structure, which could effectively compensate for the inferior rate performance of NM64 and the poor cycling performance of LMO. Specifically, when the mass ratio of NM64 to LMO is 85:15, the NM64 and LMO particles not only uniformly fill their respective inter-particle gaps, effectively increasing the compaction density of the binary blended materials, but also exhibit comprehensively enhanced electrochemical properties in terms of high specific capacity (154.29 mA h g−1 at the first cycle), long cycling life span (79.7% at 0.2C after 100 cycles), and excellent rate performance (70.70 mA h g−1 at 2C). Such ingeniously designed cobalt-free oxides cathode will pave the new avenue in the sustainable development of economical oxides cathodes for high-performance lithium-ion batteries. [ABSTRACT FROM AUTHOR]

Objective: The authors investigated the functional status at ICU admission and at hospital discharge, and the impact of dysfunctions on survivors' lifespan. Method: Single-center retrospective cohort. The FSS (Functional Status Scale) was calculated at ICU admission and at hospital discharge. A new morbidity was defined as an increase in FSS = 3. Results: Among 1002 patients, there were 855 survivors. Of these, 194 (22.6%) had died by the end of the study; 45 (5.3%) had a new morbidity. Means in the motor domain at admission and discharge were 1.37 (SD: 0.82) and 1.53 (SD 0.95, p = 0.002). In the feeding domain, the means were 1.19 (SD 0.63) and 1.30 (SD 0.76), p = 0.002; global means were 6.93 (SD 2.45) and 7.2 (SD 2.94), p = 0.007. Acute respiratory failure requiring mechanical ventilation, the score PRISM IV, age < 5 years, and central nervous system tumors were independent predictors of new morbidity. New morbidity correlated with lower odds of survival after hospital discharge, considering all causes of death (p = 0.014), and was independently predictive of death (Cox hazard ratio = 1.98). In Weibull models, shortening in the life span of 14.2% (p = 0.014) was estimated as a new morbidity. Conclusions: New morbidities are related to age, disease severity at admission, and SNC tumors. New morbidities, in turn, correlate with lower probabilities of survival and shortening of the remaining life span. Physical rehabilitation interventions in this population of children may have the potential to provide an increase in lifespan. [ABSTRACT FROM AUTHOR]

Heme oxygenase (HO) has been shown to control various cellular processes in both mammals and Drosophila melanogaster. Here, we investigated how changes in HO levels in neurons and glial cells during development affect adult flies, by using the TARGET Drosophila system to manipulate the expression of the ho gene. The obtained data showed differences in adult survival, maximum lifespan, climbing, locomotor activity, and sleep, which depended on the level of HO (after ho up-regulation or downregulation), the timing of expression (chronic or at specific developmental stages), cell types (neurons or glia), sex (males or females), and age of flies. In addition to ho, the effects of changing the mRNA level of the Drosophila CNC factor gene (NRF2 homolog in mammals and master regulator of HO), were also examined to compare with those observed after changing ho expression. We showed that HO levels in neurons and glia must be maintained at an appropriate physiological level during development to ensure the well-being of adults. We also found that the downregulation of ho in either neurons or glia in the brain is compensated by ho expressed in the retina. [ABSTRACT FROM AUTHOR]

There seem to be numerous items which have been developed using IoT devices and are network overhead. We must consider factors like reliability, minimal energy consumption, etc. To advance IoT, solutions must be found for issues with scalability, dependability, network optimization, and quality of service (QoS). The proposed approach considered a heterogeneous network with a long lifespan and high throughput while using less electricity. Specifications such as Area, Nodes, Sink location, and Data Aggregation must be given. Throughput, data communication rate, analysis of live nodes, and a reduction in node energy consumption are all factors in this method's cluster head selection. But creating an embedded IoT system is complicated. We considered the ADEEC approach for autonomous cellular networks, which improves network performance and durability. It is possible to send messages in heterogeneous contexts more successfully than with current techniques. The experimental results of the proposed ADEEC outperform the throughput with 19% when compared to LEACH, 16.5% when compared to MODLEACH and 9.6% when compared to DEEC. The network life span of ADEEC outperforms 18% when compared to LEACH, 17% when compared to MODLEACH and 13% when compared to DEEC methods. [ABSTRACT FROM AUTHOR]

Summary: Wireless sensor network (WSN) is an environmental monitoring system exposing sensor nodes to various attacks. Jamming is an attack that disrupts the entire sensor network and affects the network's life span. The jammer broadcasts the signal at a frequency similar to the broadcast signal to jam the corresponding sensor node. There are many jamming detection schemes that only detect the jamming node, but they do not focus on eliminating the node that is not jamming. In this article, a novel strategy is used along with optimization to eliminate the disturbance in the sensor network and save the power consumed by nodes. The system uses the edge node, the sub‐edge node, and the cluster head for detection of jamming attack. Hyperbolic optimization is implemented in the cluster to eliminate data transmission failures. The proposed model considers the node's round trip time to detect jamming attacks. The optimization method considers the cluster head as the cluster member based on the probability of jamming in the network. The design is implemented and analyzed in MATLAB platform. As a result, the proposed method has improved the detection accuracy to 11.1% compared with extant techniques. [ABSTRACT FROM AUTHOR]

Hoverflies (Diptera, Syrphidae) are cosmopolitan, generalist flower visitors and among the most important pollinators after bees and bumblebees. The dronefly Eristalis tenax can be found in temperate and continental climates across the globe, often synanthropically. Eristalis tenax pupae of different generations and different climate zones are thus exposed to vastly different temperatures. In many insects, the ambient temperature during the pupal stage affects development, adult size, and survival; however, the effect of developmental temperature on these traits in hoverflies is comparatively poorly understood. We here reared E. tenax pupae at different temperatures, from 10°C to 25°C, and quantified the effect on adult hoverflies. We found that pupal rearing at 17°C appeared to be optimal, with high eclosion rates, longer wings, and increased adult longevity. Rearing temperatures above or below this optimum led to decreased eclosion rates, wing size, and adult survival. Similar thermal dependence has been observed in other insects. We found that rearing temperature had no significant effect on locomotor activity, coloration or weight, despite evidence of strong sexual dimorphism for each of these traits. Our findings are important as hoverflies are key pollinators, and understanding the effects of developmental temperature could potentially be useful for horticulture. [ABSTRACT FROM AUTHOR]

Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer's disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which is implicated in neuroinflammation and a broad spectrum of neurodegenerative diseases such as Alzheimer's, Huntington's, and Parkinson's diseases. We screened a panel of bioactive thiadiazolidinones (TDZDs) from our in-house library for rescue of protein aggregation in human-cell and C. elegans models of neurodegeneration. Among the tested TDZD analogs, PNR886 and PNR962 were most effective, significantly reducing both the number and intensity of Alzheimer-like tau and amyloid aggregates in human cell-culture models of pathogenic aggregation. A C. elegans strain expressing human Aβ1–42 in muscle, leading to AD-like amyloidopathy, developed fewer and smaller aggregates after PNR886 or PNR962 treatment. Moreover, age-progressive paralysis was reduced 90% by PNR886 and 75% by PNR962, and "healthspan" (the median duration of spontaneous motility) was extended 29% and 62%, respectively. These TDZD analogs also extended wild-type C. elegans lifespan by 15–30% (p < 0.001), placing them among the most effective life-extension drugs. Because the lead drug in this family, TDZD-8, inhibits GSK3β, we used molecular-dynamic tools to assess whether these analogs may also target GSK3β. In silico modeling predicted that PNR886 or PNR962 would bind to the same allosteric pocket of inactive GSK3β as TDZD-8, employing the same pharmacophore but attaching with greater avidity. PNR886 and PNR962 are thus compelling candidate drugs for treatment of tau- and amyloid-associated neurodegenerative diseases such as AD, potentially also reducing all-cause mortality. [ABSTRACT FROM AUTHOR]

Modern hip implants have a modular design. In case of wear or other damage it allows surgeons to change the tribological partners, i.e., the acetabular liner and femoral ball. In both revision and primary surgery, the secure joining of the implant components is important for the success of the operation. The two components, namely the ceramic liner and hip cup, are connected via a conical press connection and should be concentrically aligned to avoid chipping. Malseated liners can reduce the life span in situ. The amount of the joining force, which is usually applied via a hammer, depends on the surgeon. In this study, an alternative joining method for acetabular ceramic liners in hip cups was investigated, which intends to make the process more reproducible and thus safer. For this purpose, a handpiece was used to apply a defined force impulse of 4 kN. For the concentric alignment of a ceramic liner in the hip cup, an adapter was developed based on findings via a qualitative finite element (FE) analysis. Insertion and pushout tests of the acetabular cup–liner connection were performed in the laboratory with the new instrument (handpiece with the connected adapter) to evaluate the functionality of the instrument and the reproducibility of the new insertion method. For comparison, liners and acetabular cups were joined using a testing machine according to the standard. The presented results demonstrate the technical proof-of-concept of the new joining method under laboratory conditions. They meet the acceptance criteria of established manufacturers, which proves the equivalency to proven methods for joining modular implant components. To verify the improvement of the new joining method compared to the conventionally used joining method, an application-oriented study with different surgeons and the new joining instrument under clinical conditions is necessary. [ABSTRACT FROM AUTHOR]

Purpose: This paper aims to present a novel dynamic reliability model that considers the interval mixed uncertainty for the air-breathing hypersonic flight vehicle (AHFV) to guarantee flight safety and structural reliability. Design/methodology/approach: Initially, the force condition of the fuselage is analyzed based on the longitudinal elastic model of an AHFV. Subsequently, a new high-efficiency dynamic reliability model is presented to describe the failure probability evolution of the fuselage structure. For the random uncertainty problem with interval distribution parameters, the interval PHI2 method of time-dependent reliability is used to obtain the time-dependent reliability interval of the AHFV. Finally, the key variables that affect the failure probability accumulation are determined, which provide an important reference for ensuring structural reliability and improving the life span of AHFVs. Findings: It is demonstrated that the proposed reliability model can obtain more accurate dynamic reliability results for the fuselage, and it is confirmed the key variables that affect the failure probability accumulation. The results also provide an important reference for the reliability analysis of hypersonic vehicles. Originality/value: The novelty of this work comes from the first application of the PHI2 method (considering the interval mixed uncertainty) in the AHFV and the development of a new reliability model for the entire body of AHFVs. The proposed analysis scheme is implemented on the dynamic model of the AHFV, which provides a more accurate reference for improving the structural reliability and life span of AHFVs. [ABSTRACT FROM AUTHOR]

Previous research suggests Deaf signers may have different short-term and working memory processes compared with hearing nonsigners due to prolonged auditory deprivation. The direction and magnitude of these reported differences, however, are variable and dependent on memory modality (e.g., visual, verbal), stimulus type, and research design. These discrepancies have made consensus difficult to reach which, in turn, slows progress in areas such as education, medical decision-making, and cognitive sciences. The present systematic review and meta-analysis included 35 studies (N = 1,701 participants) that examined verbal (n = 15), visuospatial (n = 10), or both verbal and visuospatial (n = 10) serial-memory tasks comparing nonimplanted, Deaf signers to hearing nonsigners across the life span. Multivariate meta-analyses indicated a significant, negative effect of deafness on verbal short-term memory (forward recall), g = −1.33, SE = 0.17, p <.001, 95% CI [−1.68, −0.98], and working memory (backward recall), g = −0.66, SE = 0.11, p <.001, 95% CI [−0.89, −0.45], but no significant effect of deafness on visuospatial short-term memory, g = −0.055, SE = 0.17, p = 0.75, 95% CI [−0.39, 0.28]. Visuospatial working memory was not analyzed due to limited power. Population estimates for verbal and visuospatial short-term memory were moderated by age wherein studies with adults demonstrated a stronger hearing advantage than studies with children/adolescents. Quality estimates indicated most studies were of fair quality, with only 38% of studies involving Deaf authors. Findings are discussed in the context of both Deaf equity and models of serial memory. [ABSTRACT FROM AUTHOR]

The National Institute on Aging sponsored a symposium at the Gerontological Society of America (GSA) annual meeting in Indianapolis, Indiana, to discuss recent discoveries related to senescent and inflammatory mechanisms in aging and disease. Consistent with the 2022 Biological Sciences GSA program led by Dr. Rozalyn Anderson, the symposium featured early-stage investigators and a leader in the field of geroscience research. Cell senescence and immune interactions coordinate homeostatic and protective programming throughout the life span. Dysfunctional communication in this exchange eventuates in inflammation-related compositional changes in aged tissues, including propagation of the senescence-associated secretory phenotype and accumulation of senescent and exhausted immune cells. Presentations in this symposium explored senescent and immune-related dysfunction in aging from diverse viewpoints and featured emerging cellular and molecular methods. A central takeaway from the event was that the use of new models and approaches, including single-cell -omics, novel mouse models, and 3D culture systems, is revealing dynamic properties and interactions of senescent and immune cell fates. This knowledge is critical for devising new therapeutic approaches with important translational relevance. [ABSTRACT FROM AUTHOR]