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599 results on '"Kuroki, Hiroshi"'

154. Ultrasound Can Detect Macroscopically Undetectable Changes in Osteoarthritis Reflecting the Superficial Histological and Biochemical Degeneration: Ex Vivo Study of Rabbit and Human Cartilage

Author

Nishitani, Kohei, primary, Kobayashi, Masahiko, additional, Kuroki, Hiroshi, additional, Mori, Koji, additional, Shirai, Takaaki, additional, Satake, Tsuyoshi, additional, Nakamura, Shinnichiro, additional, Arai, Ryuzo, additional, Nakagawa, Yasuaki, additional, Nakamura, Takashi, additional, and Matsuda, Shuichi, additional

Published
2014
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168. Longitudinal evaluation of cartilage after osteochondral autogenous transfer with delayed gadolinium-enhanced MRI of the cartilage (dGEMRIC)

Author

Shirai, Takaaki, primary, Kobayashi, Masahiko, additional, Nakamura, Shinichiro, additional, Arai, Ryuzo, additional, Nishitani, Kohei, additional, Satake, Tsuyoshi, additional, Dahlberg, Leif E., additional, Kuroki, Hiroshi, additional, Nakagawa, Yasuaki, additional, Okada, Tomohisa, additional, Togashi, Kaori, additional, and Nakamura, Takashi, additional

Published
2011
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169. Study on Lumbar Disc Herniation with Cauda Equina Syndrome

Author

Inomata, Naoki, primary, Kuroki, Hiroshi, additional, Hamanaka, Hideaki, additional, Masuda, Hiroshi, additional, Fukushima, Shuichiro, additional, Kuroki, Shuji, additional, Higa, Kiyoshi, additional, Higuchi, Seiji, additional, Nagai, Takuya, additional, Kubo, Shinichiro, additional, and Chosa, Etsuo, additional

Published
2011
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172. Evaluation of Surgical Site Infection in Spinal Surgery

Author

Hamanaka, Hideaki, primary, Kubo, Shinichiro, additional, Kuroki, Hiroshi, additional, Hanado, Shoji, additional, Inomata, Naoki, additional, Kuroki, Shuji, additional, Higa, Kiyoshi, additional, Kawano, Masamitsu, additional, and Chosa, Etsuo, additional

Published
2010
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178. Idiopathic Spinal Epidural Lipomatosis: A Case Report

Author

Hiyoshi, Masaru, primary, Kubo, Shinichiro, additional, Kuroki, Hiroshi, additional, Hamanaka, Hideaki, additional, Hanado, Shoji, additional, Kaida, Hiroshi, additional, Inomata, Naoki, additional, Yamaguchi, Shihoko, additional, and Chosa, Etsuo, additional

Published
2009
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180. Ultrasound has the potential to detect degeneration of articular cartilage clinically, even if the information is obtained from an indirect measurement of intrinsic physical characteristics

Author

Kuroki, Hiroshi, primary, Nakagawa, Yasuaki, additional, Mori, Koji, additional, Kobayashi, Masahiko, additional, Yasura, Ko, additional, Okamoto, Yukihiro, additional, Suzuki, Takashi, additional, Nishitani, Kohei, additional, and Nakamura, Takashi, additional

Published
2009
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186. Lumbar Ligamentum Flavum Hematoma: A Case Report

Author

Kojima, Takeshi, primary, Kuroki, Hiroshi, additional, Hamanaka, Hideaki, additional, Kubo, Shinichiro, additional, Hanado, Shoji, additional, Inomata, Naoki, additional, Kiriya, Riki, additional, Fukushima, Katsuhiko, additional, Komaki, Wataru, additional, and Chosa, Etsuo, additional

Published
2008
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189. Estimation of the mechanical property of meniscus using ultrasound: Examinations of native meniscus and effects of enzymatic digestion

Author

Yasura, Ko, primary, Mizuno, Yasuyuki, additional, Nakagawa, Yasuaki, additional, Mori, Koji, additional, Takenaka, Makoto, additional, Ohashi, Tetsuo, additional, Yamada, Keisuke, additional, Kobayashi, Masahiko, additional, Ando, Keiji, additional, Kuroki, Hiroshi, additional, Suzuki, Takashi, additional, Ikeuchi, Ken, additional, Tsutsumi, Sadami, additional, and Nakamura, Takashi, additional

Published
2007
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192. A Case of Fracture of the Sacrum Showing that Measurement of Anorectal Internal Pressure is Useful in Predicting Prognosis

Author

Sugata, Ko, primary, Kubo, Shinichiro, additional, Kuroki, Hiroshi, additional, Hanado, Shoji, additional, Hamanaka, Hideaki, additional, Uemichi, Kazushi, additional, Kiriya, Riki, additional, Kurogi, Shuji, additional, Kai, Itono, additional, Fukuda, Hajime, additional, Kawano, Yuki, additional, Chosa, Etsuo, additional, and Hotokezaka, Masayuki, additional

Published
2007
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193. Clinical Phenotype Classifications Based on Static Varus Alignment and Varus Thrust in Japanese Patients With Medial Knee Osteoarthritis.

Author

Iijima, Hirotaka, Fukutani, Naoto, Aoyama, Tomoki, Fukumoto, Takahiko, Uritani, Daisuke, Kaneda, Eishi, Ota, Kazuo, Kuroki, Hiroshi, and Matsuda, Shuichi

Subjects
ACADEMIC medical centers, ANALYSIS of variance, CONFIDENCE intervals, FISHER exact test, KNEE diseases, MULTIVARIATE analysis, OSTEOARTHRITIS, QUESTIONNAIRES, RESEARCH funding, STATISTICS, PHENOTYPES, LOGISTIC regression analysis, DATA analysis, INTER-observer reliability, CROSS-sectional method, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio, KRUSKAL-Wallis Test
Abstract

Objective. To investigate the association between knee pain during gait and 4 clinical phenotypes based on static varus alignment and varus thrust in patients with medial knee osteoarthritis (OA). Methods. Patients in an orthopedic clinic (n5266) diagnosed as having knee OA (Kellgren/Lawrence [K/L] grade ≥1) were divided into 4 phenotype groups according to the presence or absence of static varus alignment and varus thrust (dynamic varus): no varus (n5173), dynamic varus (n517), static varus (n550), and static varus1dynamic varus (n526).The knee range of motion, spatiotemporal gait parameters, visual analog scale scores for knee pain, and scores on the Japanese Knee Osteoarthritis Measure were used to assess clinical outcomes. Multiple logistic regression analyses identified the relationship between knee pain during gait and the 4 phenotypes, adjusted for possible risk factors, including age, sex, body mass index, K/L grade, and gait velocity. Results. Multiple logistic regression analysis showed that varus thrust without varus alignment was associated with knee pain during gait (odds ratio [OR] 3.30, 95% confidence interval [95% CI] 1.08-12.4), and that varus thrust combined with varus alignment was strongly associated with knee pain during gait (OR 17.1, 95% CI 3.19- 320.0). Sensitivity analyses applying alternative cutoff values for defining static varus alignment showed comparable results. Conclusion. Varus thrust with or without static varus alignment was associated with the occurrence of knee pain during gait. Tailored interventions based on individual malalignment phenotypes may improve clinical outcomes in patients with knee OA. [ABSTRACT FROM AUTHOR]

Published
2015
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194. Two siblings with neuropathic scoliosis caused by Chiari malformation type I with syringomyelia.

Author

Kuroki, Hiroshi, Inomata, Naoki, Hamanaka, Hideaki, Higa, Kiyoshi, Chosa, Etsuo, and Tajima, Naoya

Subjects
*SCOLIOSIS, *SPINE abnormalities, *NEUROPATHY, *ARNOLD-Chiari deformity, *SYRINGOMYELIA
Abstract

The article describes the case of two siblings with neuropathic scoliosis due to Chiari malformation type I (CMI) with syringomyelia. CMI has been regarded as a sporadic condition without a heritable etiology, however, there have been several case reports determining familial aggregation and clustering of CMI, indicating a genetic basis.

Published
2015
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195. Culture temperature affects redifferentiation and cartilaginous extracellular matrix formation in dedifferentiated human chondrocytes.

Author

Ito, Akira, Aoyama, Tomoki, Iijima, Hirotaka, Tajino, Junichi, Nagai, Momoko, Yamaguchi, Shoki, Zhang, Xiangkai, and Kuroki, Hiroshi

Subjects
CARTILAGE cells, METABOLISM, CARTILAGE, BONE grafting, BONE remodeling
Abstract

ABSTRACT To date, there have been few studies on how temperature affects the phenotype and metabolism of human chondrocytes. Thus, the purpose of this study was to elucidate the effects of culture temperature on chondrocyte redifferentiation and extracellular matrix (ECM) formation using dedifferentiated mature human chondrocytes in vitro. Dedifferentiated chondrocytes were cultured in a pellet culture system for up to 21 days. The pellets were randomly divided into three groups with different culture temperature (32, 37, and 41°C). Chondrocyte redifferentiation and ECM formation were evaluated by wet weight, messenger ribonucleic acid (mRNA), histological, and biochemical analyses. The results showed that the wet weight and the mRNA expressions of collagen type II A1 and cartilage oligomeric matrix protein at 37°C were higher than the corresponding values at 32°C. The histological and biochemical analyses revealed that the syntheses of type II collagen and proteoglycan were promoted at 37°C compared to those at 32°C, whereas they were considerably inhibited at 41°C. In conclusion, the results obtained herein indicated that temperature affects chondrocyte redifferentiation and ECM formation, and modulation of temperature might thus represent an advantageous means to regulate the phenotype and biosynthetic activity of chondrocytes. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:633-639, 2015. [ABSTRACT FROM AUTHOR]

Published
2015
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196. Regional comparisons of porcine menisci.

Author

Zhang, Xiangkai, Aoyama, Tomoki, Ito, Akira, Tajino, Junichi, Nagai, Momoko, Yamaguchi, Shoki, Iijima, Hirotaka, and Kuroki, Hiroshi

Subjects
BIOMECHANICS, BIOCHEMISTRY, MENISCUS (Anatomy), SCANNING electron microscopy, LABORATORY swine
Abstract

ABSTRACT The purpose of this study was to analyze histologic, biochemical, and biomechanical differences between zonal, regional, and anatomic locations of porcine menisci. We evaluated six menisci removed from pigs. Medial and lateral menisci were divided into three regions: anterior, middle, and posterior. In each portion, the central zone (CZ) and peripheral zone (PZ) were examined histologically (hematoxylin & eosin, safranin O/Fast green, and picrosiriusred staining), using scanning electron microscopy, biochemically (hydroxyproline assay for collagen content and dimethylmethylene blue assay for glycosaminoglycan [GAG] content), and biomechanically (compression testing). Collagen content in the CZ was lower than that in the PZ. GAG content in the CZ was higher than that in the PZ. GAG content in the PZ of the posterior portion was significantly higher than that in the anterior and middle portions. Compression strength in the CZ was higher than that in the PZ. The differences in cellular phenotype, vascular penetration, and ECM not only between CZ and PZ but also among the anterior, middle, and posterior portions were clarified in the immature porcine meniscus. This result helps further our understanding of the biological characteristic of the meniscus. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:1602-1611, 2014. [ABSTRACT FROM AUTHOR]

Published
2014
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