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890 results on '"Kupper, Thomas S"'

155. Hair Follicle Apoptosis and Bcl-2

Author

Müller-Röver, Sven, Rossiter, Heidi, Lindner, Gerd, Peters, Eva M.J., Kupper, Thomas S., and Paus, Ralf

Published
1999

156. Radiotherapy Eradicates Malignant T Cells and Is Associated with Improved Survival in Early-Stage Mycosis Fungoides

Author

O'Malley, John T., primary, de Masson, Adele, additional, Lowry, Elizabeth L., additional, Giobbie-Hurder, Anita, additional, LeBoeuf, Nicole R., additional, Larocca, Cecilia, additional, Gehad, Ahmed, additional, Seger, Edward, additional, Teague, Jessica E., additional, Fisher, David C., additional, Kupper, Thomas S., additional, Devlin, Phillip M., additional, and Clark, Rachael A., additional

Published
2020
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157. Fatty-Acid-Binding Protein 5 Induces Th17 Polarization in Atopic Dermatitis Patients with Atopic March

Author

Lee, Jungsoo, primary, Kim, Bomi, additional, Chu, Howard, additional, Zhang, KeLun, additional, Kim, Hyeran, additional, Kim, Ji Hye, additional, Kim, Seo Hyeong, additional, Pan, Youdong, additional, Noh, Ji Yeon, additional, Sun, ZhengWang, additional, Lee, Jongsun, additional, Jeong, Kyoung Yong, additional, Park, Kyung Hee, additional, Park, Jung-Won, additional, Kupper, Thomas S, additional, Park, Chang Ook, additional, and Lee, Kwang Hoon, additional

Published
2020
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166. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

Author

Deng, Wanyan, Bai, Yang, Deng, Fan, Pan, Youdong, Mei, Shenglin, Zheng, Zengzhang, Min, Rui, Wu, Zeyu, Li, Wu, Miao, Rui, Zhang, Zhibin, Kupper, Thomas S., Lieberman, Judy, and Liu, Xing

Abstract

Gasdermins, a family of five pore-forming proteins (GSDMA–GSDME) in humans expressed predominantly in the skin, mucosa and immune sentinel cells, are key executioners of inflammatory cell death (pyroptosis), which recruits immune cells to infection sites and promotes protective immunity1,2. Pore formation is triggered by gasdermin cleavage1,2. Although the proteases that activate GSDMB, C, D and E have been identified, how GSDMA—the dominant gasdermin in the skin—is activated, remains unknown. Streptococcus pyogenes, also known as group A Streptococcus(GAS), is a major skin pathogen that causes substantial morbidity and mortality worldwide3. Here we show that the GAS cysteine protease SpeB virulence factor triggers keratinocyte pyroptosis by cleaving GSDMA after Gln246, unleashing an active N-terminal fragment that triggers pyroptosis. Gsdma1genetic deficiency blunts mouse immune responses to GAS, resulting in uncontrolled bacterial dissemination and death. GSDMA acts as both a sensor and substrate of GAS SpeB and as an effector to trigger pyroptosis, adding a simple one-molecule mechanism for host recognition and control of virulence of a dangerous microbial pathogen.

Published
2022
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170. Biology of the Interleukin-1 Receptor

Author

Dower, Steven K., Qwarnstrom, Eva E., Page, Roy C., Blanton, Rebecca A., Kupper, Thomas S., Raines, Elaine, Ross, Russell, and Sims, John E.

Published
1990

174. T-cell trafficking plays an essential role in tumor immunity

Author

Aires, Daniel J., primary, Yoshida, Masaru, additional, Richardson, Stephen K., additional, Bai, Mei, additional, Liu, Luzheng, additional, Moreno, Roberto, additional, Lazar, Alexander J.F., additional, Wick, Jo A., additional, Rich, Benjamin E., additional, Murphy, George, additional, Blumberg, Richard S., additional, Fuhlbrigge, Robert C., additional, and Kupper, Thomas S., additional

Published
2019
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175. Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge.

Author

Pan, Youdong, Liu, Luzheng, Tian, Tian, Zhao, Jingxia, Park, Chang Ook, Lofftus, Serena Y., Stingley, Claire A., Yan, Yu, Mei, Shenglin, Liu, Xing, and Kupper, Thomas S.

Subjects
IMMUNIZATION, T cells, SMALLPOX vaccines, COVID-19 pandemic, PATHOLOGY
Abstract

Modified Vaccinia Ankara (MVA) was recently approved as a smallpox vaccine. Variola is transmitted by respiratory droplets and MVA immunization by skin scarification (s.s.) protected mice far more effectively against lethal respiratory challenge with vaccinia virus (VACV) than any other route of delivery, and at lower doses. Comparisons of s.s. with intradermal, subcutaneous, or intramuscular routes showed that MVAOVA s.s.-generated T cells were both more abundant and transcriptionally unique. MVAOVA s.s. produced greater numbers of lung Ova-specific CD8+ TRM and was superior in protecting mice against lethal VACVOVA respiratory challenge. Nearly as many lung TRM were generated with MVAOVA s.s. immunization compared to intra-tracheal immunization with MVAOVA and both routes vaccination protected mice against lethal pulmonary challenge with VACVOVA. Strikingly, MVAOVA s.s.-generated effector T cells exhibited overlapping gene transcriptional profiles to those generated via intra-tracheal immunization. Overall, our data suggest that heterologous MVA vectors immunized via s.s. are uniquely well-suited as vaccine vectors for respiratory pathogens, which may be relevant to COVID-19. In addition, MVA delivered via s.s. could represent a more effective dose-sparing smallpox vaccine. [ABSTRACT FROM AUTHOR]

Published
2021
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177. Tumor clone frequency is a robust predictor of progression and survival in patients with Stage IB mycosis fungoides

Author

De Masson, Adele, primary, O'Malley, John T., additional, Lowry, Elizabeth L., additional, Leboeuf, Nicole R., additional, Elco, Christopher P., additional, Garcia, Sarah, additional, Teague, Jessica E., additional, Robins, Harlan, additional, Divito, Sherrie, additional, Clark, Rachael A., additional, and Kupper, Thomas S., additional

Published
2018
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178. Staged development of long-lived T-cell receptor αβ T H 17 resident memory T-cell population to Candida albicans after skin infection

Author

Park, Chang Ook, primary, Fu, Xiujun, additional, Jiang, Xiaodong, additional, Pan, Youdong, additional, Teague, Jessica E., additional, Collins, Nicholas, additional, Tian, Tian, additional, O'Malley, John T., additional, Emerson, Ryan O., additional, Kim, Ji Hye, additional, Jung, Yookyung, additional, Watanabe, Rei, additional, Fuhlbrigge, Robert C., additional, Carbone, Francis R., additional, Gebhardt, Thomas, additional, Clark, Rachael A., additional, Lin, Charles P., additional, and Kupper, Thomas S., additional

Published
2018
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181. High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides

Author

de Masson, Adele, primary, O’Malley, John T., additional, Elco, Christopher P., additional, Garcia, Sarah S., additional, Divito, Sherrie J., additional, Lowry, Elizabeth L., additional, Tawa, Marianne, additional, Fisher, David C., additional, Devlin, Phillip M., additional, Teague, Jessica E., additional, Leboeuf, Nicole R., additional, Kirsch, Ilan R., additional, Robins, Harlan, additional, Clark, Rachael A., additional, and Kupper, Thomas S., additional

Published
2018
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183. A primary role for human central memory cells in tissue immunosurveillance.

Author

Gehad, Ahmed, Gehad, Ahmed, Teague, Jessica E, Matos, Tiago R, Huang, Victor, Yang, Chao, Watanabe, Rei, O'Malley, John T, Trimble, Cornelia L, Kupper, Thomas S, Clark, Rachael A, Gehad, Ahmed, Gehad, Ahmed, Teague, Jessica E, Matos, Tiago R, Huang, Victor, Yang, Chao, Watanabe, Rei, O'Malley, John T, Trimble, Cornelia L, Kupper, Thomas S, and Clark, Rachael A

Abstract

Central memory T cells (TCM) patrol lymph nodes, providing central immunosurveillance against known pathogens, but have not been described as conducting primary tissue immunosurveillance. We analyzed the expression of tissue-homing addressins in human TCM vs effector memory T cells (TEM) from the same donors. In humans, the majority of human TCM were tropic for either skin or gut, and the overall tissue tropism of TCM was comparable to that of TEM TCM were present in healthy, noninflamed human skin, lung, colon, and cervix, suggesting a role for TCM in the primary immunosurveillance of peripheral tissues. TCM also had potent effector functions; 80% of CD8+ TCM produced TC1/TC2/TC17/TC22 cytokines. TCM injected into human skin-grafted mice migrated into skin and induced inflammatory eruptions comparable to TEM-injected mice. In summary, human TCM express peripheral tissue-homing receptors at levels similar to their effector memory counterparts, are found in healthy human tissues, have impressive effector functions, and can act alone to induce skin inflammation in human engrafted mice. Our studies support a novel role for human TCM in primary immunosurveillance of peripheral tissues and highlight the important role of this long-lived cell type in tissue-based immune responses.

Published
2018

185. ABCB5 Identifies Immunoregulatory Dermal Cells

Author

Schatton, Tobias, Yang, Jun, Kleffel, Sonja, Uehara, Mayuko, Barthel, Steven R., Schlapbach, Christoph, Zhan, Qian, Dudeney, Stephen, Mueller, Hansgeorg, Lee, Nayoung, de Vries, Juliane C., Meier, Barbara, Vander Beken, Seppe, Kluth, Mark A., Ganss, Christoph, Sharpe, Arlene H., Waaga-Gasser, Ana Maria, Sayegh, Mohamed H., Abdi, Reza, Scharffetter-Kochanek, Karin, Murphy, George F., Kupper, Thomas S., Frank, Natasha Y., and Frank, Markus H.

Published
2015
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186. Physical disruption of skin during poxvirus immunization is critical for the generation of highly protective T cell-mediated immunity

Author

Liu, Luzheng, Zhong, Qiong, Tian, Tian, Dubin, Krista, Athale, Shruti K., and Kupper, Thomas S.

Subjects
Immunity, Cellular, Mice, viruses, Poxviridae, T-Lymphocytes, Animals, Viral Vaccines, Article
Abstract

Variola major (smallpox) infection claimed hundreds of millions lives before it was eradicated by a simple vaccination strategy: epicutaneous application of the related orthopoxvirus vaccinia virus (VACV) to superficially injured skin (skin scarification, s.s.). However, the remarkable success of this strategy was attributed to the immunogenicity of VACV rather than to the unique mode of vaccine delivery. We now show that VACV immunization via s.s., but not conventional injection routes, is essential for the generation of superior T cell-mediated immune responses that provide complete protection against subsequent challenges, independent of neutralizing antibodies. Skin-resident effector memory T cells (T(EM) cells) provide complete protection against cutaneous challenge, whereas protection against lethal respiratory challenge requires both respiratory mucosal T(EM) cells and central memory T cells (T(CM) cells). Vaccination with recombinant VACV (rVACV) expressing a tumor antigen was protective against tumor challenge only if delivered via the s.s. route; it was ineffective if delivered by hypodermic injection. The clinically safer nonreplicative modified vaccinia Ankara virus (MVA) also generated far superior protective immunity when delivered via the s.s. route compared to intramuscular (i.m.) injection as used in MVA clinical trials. Thus, delivery of rVACV-based vaccines, including MVA vaccines, through physically disrupted epidermis has clear-cut advantages over conventional vaccination via hypodermic injection.

Published
2010

188. Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma

Author

Jain, Salvia, primary, Washington, Abigail, additional, Leaf, Rebecca Karp, additional, Bhargava, Parul, additional, Clark, Rachael A., additional, Kupper, Thomas S., additional, Stroopinsky, Dina, additional, Pyzer, Athalia, additional, Cole, Leandra, additional, Nahas, Myrna, additional, Apel, Arie, additional, Rosenblatt, Jacalyn, additional, Arnason, Jon, additional, Kufe, Donald, additional, and Avigan, David, additional

Published
2017
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192. Inhibiting janus kinases to treat alopecia areata

Author

Divito, Sherrie J. and Kupper, Thomas S.

Subjects
Care and treatment, Analysis, Research, Alopecia -- Care and treatment -- Research, Phosphotransferases -- Research -- Analysis, Baldness -- Care and treatment -- Research
Abstract

Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8α[β.sup.+][NKG2D.sup.+] T effector memory cells mediate alopecia [...]

Published
2014

193. Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides

Author

Yu, Zizi, Vieyra-Garcia, Pablo, Benezeder, Theresa, Crouch, Jack D., Kim, Ira R., O’Malley, John T., Devlin, Phillip M., Gehad, Ahmed, Zhan, Qian, Gudjonsson, Johann E., Sarkar, Mrinal K., Kahlenberg, J. Michelle, Gerard, Nega, Teague, Jessica E., Kupper, Thomas S., LeBoeuf, Nicole R., Larocca, Cecilia, Tawa, Marianne, Pomahac, Bohdan, Talbot, Simon G., Orgill, Dennis P., Wolf, Peter, and Clark, Rachael A.

Abstract

Transcriptional profiling demonstrated markedly reduced type I IFN gene expression in untreated mycosis fungoides (MF) skin lesions compared with that in healthy skin. Type I IFN expression in MF correlated with antigen-presenting cell–associated IRF5 before psoralen plus UVA therapy and epithelial ULBP2 after therapy, suggesting an enhancement of epithelial type I IFN. Immunostains confirmed reduced baseline type I IFN production in MF and increased levels after psoralen plus UVA treatment in responding patients. Effective tumor clearance was associated with increased type I IFN expression, enhanced recruitment of CD8+T cells into skin lesions, and expression of genes associated with antigen-specific T-cell activation. IFNk, a keratinocyte-derived inducer of type I IFNs, was increased by psoralen plus UVA therapy and expression correlated with upregulation of other type I IFNs. In vitro, deletion of keratinocyte IFNk decreased baseline and UVA-induced expression of type I IFN and IFN response genes. In summary, we find a baseline deficit in type I IFN production in MF that is restored by psoralen plus UVA therapy and correlates with enhanced antitumor responses. This may explain why MF generally develops in sun-protected skin and suggests that drugs that increase epithelial type I IFNs, including topical MEK and EGFR inhibitors, may be effective therapies for MF.

Published
2024
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194. Round fingerpad sign: an early sign of scleroderma

Author

Mizutani, Hitoshi, Mizutani, Tomoko, Okada, Hiroaki, Kupper, Thomas S., and Shimizu, Masayuki

Subjects
Skin diseases -- Diagnosis, Fingers -- Abnormalities, Scleroderma (Disease) -- Diagnosis, Health
Abstract

Cutaneous scleroderma is a disease of the skin. It occurs when fibrous connective tissue underneath the skin begins to swell, thicken and harden. This disease is resistant to drug treatment, and once it is established it is irreversible. If the scleroderma spreads to the internal organs (systemic scleroderma), then the disease is life-threatening. Scleroderma is difficult to diagnose when it is in the early stages. This is because there are not many visible signs of the disease. The fingers are usually the first body parts to be affected, and in some cases the disease remains only in the fingers. In order to identify a clinical feature that might be predictive of scleroderma, the fingers of 36 patients with progressive systemic sclerosis (PSS) were compared with the fingers of 120 women without sclerosis (control group). The fingerpads of the women in the control group had a normal peaked contour. However, all of the women with PSS had rounded fingerpads on their ring (fourth) fingers. This same phenomenon of rounded fingerpads was observed in 69 out of 72 ring fingers of patients with mixed connective tissue disease, and also in all 24 ring fingers of patients with two other types of skin disease (Raynaud's phenomenon and sclerodactyly). It is concluded that the presence of a rounded fingerpad on the fourth finger of the right or left hand may indicate scleroderma, and that the condition should be evaluated further. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

195. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Author

Townsend, Elizabeth C, Townsend, Elizabeth C, Murakami, Mark A, Christodoulou, Alexandra, Christie, Amanda L, Köster, Johannes, DeSouza, Tiffany A, Morgan, Elizabeth A, Kallgren, Scott P, Liu, Huiyun, Wu, Shuo-Chieh, Plana, Olivia, Montero, Joan, Stevenson, Kristen E, Rao, Prakash, Vadhi, Raga, Andreeff, Michael, Armand, Philippe, Ballen, Karen K, Barzaghi-Rinaudo, Patrizia, Cahill, Sarah, Clark, Rachael A, Cooke, Vesselina G, Davids, Matthew S, DeAngelo, Daniel J, Dorfman, David M, Eaton, Hilary, Ebert, Benjamin L, Etchin, Julia, Firestone, Brant, Fisher, David C, Freedman, Arnold S, Galinsky, Ilene A, Gao, Hui, Garcia, Jacqueline S, Garnache-Ottou, Francine, Graubert, Timothy A, Gutierrez, Alejandro, Halilovic, Ensar, Harris, Marian H, Herbert, Zachary T, Horwitz, Steven M, Inghirami, Giorgio, Intlekofer, Andrew M, Ito, Moriko, Izraeli, Shai, Jacobsen, Eric D, Jacobson, Caron A, Jeay, Sébastien, Jeremias, Irmela, Kelliher, Michelle A, Koch, Raphael, Konopleva, Marina, Kopp, Nadja, Kornblau, Steven M, Kung, Andrew L, Kupper, Thomas S, LeBoeuf, Nicole R, LaCasce, Ann S, Lees, Emma, Li, Loretta S, Look, A Thomas, Murakami, Masato, Muschen, Markus, Neuberg, Donna, Ng, Samuel Y, Odejide, Oreofe O, Orkin, Stuart H, Paquette, Rachel R, Place, Andrew E, Roderick, Justine E, Ryan, Jeremy A, Sallan, Stephen E, Shoji, Brent, Silverman, Lewis B, Soiffer, Robert J, Steensma, David P, Stegmaier, Kimberly, Stone, Richard M, Tamburini, Jerome, Thorner, Aaron R, van Hummelen, Paul, Wadleigh, Martha, Wiesmann, Marion, Weng, Andrew P, Wuerthner, Jens U, Williams, David A, Wollison, Bruce M, Lane, Andrew A, Letai, Anthony, Bertagnolli, Monica M, Ritz, Jerome, Brown, Myles, Long, Henry, Aster, Jon C, Shipp, Margaret A, Griffin, James D, Weinstock, David M, Townsend, Elizabeth C, Townsend, Elizabeth C, Murakami, Mark A, Christodoulou, Alexandra, Christie, Amanda L, Köster, Johannes, DeSouza, Tiffany A, Morgan, Elizabeth A, Kallgren, Scott P, Liu, Huiyun, Wu, Shuo-Chieh, Plana, Olivia, Montero, Joan, Stevenson, Kristen E, Rao, Prakash, Vadhi, Raga, Andreeff, Michael, Armand, Philippe, Ballen, Karen K, Barzaghi-Rinaudo, Patrizia, Cahill, Sarah, Clark, Rachael A, Cooke, Vesselina G, Davids, Matthew S, DeAngelo, Daniel J, Dorfman, David M, Eaton, Hilary, Ebert, Benjamin L, Etchin, Julia, Firestone, Brant, Fisher, David C, Freedman, Arnold S, Galinsky, Ilene A, Gao, Hui, Garcia, Jacqueline S, Garnache-Ottou, Francine, Graubert, Timothy A, Gutierrez, Alejandro, Halilovic, Ensar, Harris, Marian H, Herbert, Zachary T, Horwitz, Steven M, Inghirami, Giorgio, Intlekofer, Andrew M, Ito, Moriko, Izraeli, Shai, Jacobsen, Eric D, Jacobson, Caron A, Jeay, Sébastien, Jeremias, Irmela, Kelliher, Michelle A, Koch, Raphael, Konopleva, Marina, Kopp, Nadja, Kornblau, Steven M, Kung, Andrew L, Kupper, Thomas S, LeBoeuf, Nicole R, LaCasce, Ann S, Lees, Emma, Li, Loretta S, Look, A Thomas, Murakami, Masato, Muschen, Markus, Neuberg, Donna, Ng, Samuel Y, Odejide, Oreofe O, Orkin, Stuart H, Paquette, Rachel R, Place, Andrew E, Roderick, Justine E, Ryan, Jeremy A, Sallan, Stephen E, Shoji, Brent, Silverman, Lewis B, Soiffer, Robert J, Steensma, David P, Stegmaier, Kimberly, Stone, Richard M, Tamburini, Jerome, Thorner, Aaron R, van Hummelen, Paul, Wadleigh, Martha, Wiesmann, Marion, Weng, Andrew P, Wuerthner, Jens U, Williams, David A, Wollison, Bruce M, Lane, Andrew A, Letai, Anthony, Bertagnolli, Monica M, Ritz, Jerome, Brown, Myles, Long, Henry, Aster, Jon C, Shipp, Margaret A, Griffin, James D, and Weinstock, David M

Abstract

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease.

Published
2016

198. Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma

Author

Jain, Salvia, primary, Washington, Abigail J., additional, Leaf, Rebecca Karp, additional, Bhargava, Parul, additional, Clark, Rachael, additional, Kupper, Thomas S., additional, Stroopinsky, Dina, additional, Pyzer, Athalia Rachel, additional, Cole, Leandra, additional, Nahas, Myrna R., additional, Apel, Arie, additional, Rosenblatt, Jacalyn, additional, Arnason, Jon, additional, Kufe, Donald, additional, and Avigan, David E., additional

Published
2016
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199. Toward an Objective Diagnostic Test for Bacterial Cellulitis

Author

Pallin, Daniel J., primary, Bry, Lynn, additional, Dwyer, Richard C., additional, Lipworth, Adam D., additional, Leung, Donald Y., additional, Camargo, Carlos A., additional, Kupper, Thomas S., additional, Filbin, Michael R., additional, and Murphy, George F., additional

Published
2016
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