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1,348 results on '"Krogh V"'

152. Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

Author

Ose, J. Fortner, R. T. Schock, H. Peeters, P. H. and Onland-Moret, N. C. Bueno-de-Mesquita, H. B. Weiderpass, E. and Gram, I. T. Overvad, K. Tjonneland, A. Dossus, L. and Fournier, A. Baglietto, L. Trichopoulou, A. Benetou, V. and Trichopoulos, D. Boeing, H. Masala, G. Krogh, V. and Matiello, A. Tumino, R. Popovic, M. Obon-Santacana, M. and Larranaga, N. Ardanaz, E. Sanchez, M-J Menendez, V. and Chirlaque, M-D Travis, R. C. Khaw, K-T Braendstedt, J. and Idahl, A. Lundin, E. Rinaldi, S. Kuhn, E. Romieu, I. and Gunter, M. J. Merritt, M. A. Riboli, E. Kaaks, R.

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

Published
2015

154. Sources of cadmium exposure in an Italian population: a cross-sectional study

Author

Tommaso Filippini, Cherubini, A., Greco, S., Maffeis, G., Malagoli Carlotta, Bottecchi, Iliaria, marcella malavolti, Sieri, S., Krogh, V., Vescovi, L., Modenesi, M., Castiglia, P., Michalke, B., and Marco Vinceti

Subjects
Sources of cadmium, diet, smoking, outdoor air pollution, outdoor air pollution, diet, smoking, Sources of cadmium
Published
2015

157. Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study

Author

Beulens JW, van der Schouw YT, Bergmann MM, Rohrmann S, Schulze MB, Buijsse B, Grobbee DE, Arriola L, Cauchi S, Tormo MJ, Allen NE, van der A. DL, Balkau B, Boeing H, Clavel Chapelon F, de Lauzon Guillan B, Franks P, Froguel P, Gonzales C, Halkjaer J, Huerta JM, Kaaks R, Key TJ, Khaw KT, Krogh V, Molina Montes E, Nilsson P, Overvad K, Palli D, Ram?n Quir?s J, Rolandsson O, Romieu I, Romaguera D, Sacerdote C, S?nchez MJ, Spijkerman AM, Teucher B, Tjonneland A, Tumino R, Sharp S, Forouhi NG, Langenberg C, Feskens EJ, Riboli E, Wareham NJ, InterAct Consortium, PANICO, SALVATORE, Beulens, Jw, van der Schouw, Yt, Bergmann, Mm, Rohrmann, S, Schulze, Mb, Buijsse, B, Grobbee, De, Arriola, L, Cauchi, S, Tormo, Mj, Allen, Ne, van der A., Dl, Balkau, B, Boeing, H, Clavel Chapelon, F, de Lauzon Guillan, B, Franks, P, Froguel, P, Gonzales, C, Halkjaer, J, Huerta, Jm, Kaaks, R, Key, Tj, Khaw, Kt, Krogh, V, Molina Montes, E, Nilsson, P, Overvad, K, Palli, D, Panico, Salvatore, Ram?n Quir?s, J, Rolandsson, O, Romieu, I, Romaguera, D, Sacerdote, C, S?nchez, Mj, Spijkerman, Am, Teucher, B, Tjonneland, A, Tumino, R, Sharp, S, Forouhi, Ng, Langenberg, C, Feskens, Ej, Riboli, E, Wareham, Nj, and Interact, Consortium

Subjects
Cohort Studies, Europe, Male, Sex Factors, Alcohol Drinking, Diabetes Mellitus, Type 2, Risk Factors, Alcoholic Beverages, Body Size, Humans, Female, Prospective Studies, Middle Aged
Abstract

OBJECTIVE: To investigate the association between alcohol consumption and type 2 diabetes, and determine whether this is modified by sex, body mass index (BMI) and beverage type. DESIGN: Multicentre prospective case-cohort study. SETTING: Eight countries from the European Prospective Investigation into Cancer and Nutrition cohort. SUBJECTS: A representative baseline sample of 16 154 participants and 12 403 incident cases of type 2 diabetes. INTERVENTIONS: Alcohol consumption assessed using validated dietary questionnaires. MAIN OUTCOME MEASURES: Occurrence of type 2 diabetes based on multiple sources (mainly self-reports), verified against medical information. RESULTS: Amongst men, moderate alcohol consumption was nonsignificantly associated with a lower incidence of diabetes with a hazard ratio (HR) of 0.90 (95% CI: 0.78-1.05) for 6.1-12.0 versus 0.1-6.0 g day(-1) , adjusted for dietary and diabetes risk factors. However, the lowest risk was observed at higher intakes of 24.1-96.0 g day(-1) with an HR of 0.86 (95% CI: 0.75-0.98). Amongst women, moderate alcohol consumption was associated with a lower incidence of diabetes with a hazard ratio of 0.82 (95% CI: 0.72-0.92) for 6.1-12.0 g day(-1) (P interaction gender

Published
2012

158. Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry

Author

Figueroa, J.D., Middlebrooks, C.D., Banday, A.R., Ye, Y., Garcia-Closas, M., Chatterjee, N., Koutros, S., Kiemeney, L.A., Rafnar, T., Bishop, T., Furberg, H., Matullo, G., Golka, K., Gago-Dominguez, M., Taylor, J.A., Fletcher, T., Siddiq, A., Cortessis, V.K., Kooperberg, C., Cussenot, O., Benhamou, S., Prescott, J., Porru, S., Dinney, C.P., Malats, N., Baris, D., Purdue, M.P., Jacobs, E.J., Albanes, D., Wang, Z., Chung, C.C., Vermeulen, S.H., Aben, K.K.H., Galesloot, T.E., Thorleifsson, G., Sulem, P., Stefansson, K., Kiltie, A.E., Harland, M., Teo, M., Offit, K., Vijai, J., Bajorin, D., Kopp, R., Fiorito, G., Guarrera, S., Sacerdote, C., Selinski, S., Hengstler, J.G., Gerullis, H., Ovsiannikov, D., Blaszkewicz, M., Castelao, J.E., Calaza, M., Martinez, M.E., Cordeiro, P., Xu, Z., Panduri, V., Kumar, R., Gurzau, E, Koppova, K., Bueno-de-Mesquita, H.B., Ljungberg, B., Clavel-Chapelon, F., Weiderpass, E., Krogh, V., Dorronsoro, M., Travis, R.C., Tjonneland, A., Brennan, P., Chang-Claude, J., Riboli, E., Conti, D., Stern, M.C., Pike, M.C., Berg, D., Yuan, J.M., Hohensee, C., Jeppson, R.P., Cancel-Tassin, G., Roupret, M., Comperat, E., Turman, C., Vivo, I. De, Giovannucci, E., Hunter, D.J., Kraft, P., Lindstrom, S., Carta, A., Pavanello, S., Arici, C., Mastrangelo, G., Kamat, A.M., Zhang, L., Gong, Y., Pu, X., Hutchinson, A., Burdett, L., Wheeler, W.A., Karagas, M.R., et al., Figueroa, J.D., Middlebrooks, C.D., Banday, A.R., Ye, Y., Garcia-Closas, M., Chatterjee, N., Koutros, S., Kiemeney, L.A., Rafnar, T., Bishop, T., Furberg, H., Matullo, G., Golka, K., Gago-Dominguez, M., Taylor, J.A., Fletcher, T., Siddiq, A., Cortessis, V.K., Kooperberg, C., Cussenot, O., Benhamou, S., Prescott, J., Porru, S., Dinney, C.P., Malats, N., Baris, D., Purdue, M.P., Jacobs, E.J., Albanes, D., Wang, Z., Chung, C.C., Vermeulen, S.H., Aben, K.K.H., Galesloot, T.E., Thorleifsson, G., Sulem, P., Stefansson, K., Kiltie, A.E., Harland, M., Teo, M., Offit, K., Vijai, J., Bajorin, D., Kopp, R., Fiorito, G., Guarrera, S., Sacerdote, C., Selinski, S., Hengstler, J.G., Gerullis, H., Ovsiannikov, D., Blaszkewicz, M., Castelao, J.E., Calaza, M., Martinez, M.E., Cordeiro, P., Xu, Z., Panduri, V., Kumar, R., Gurzau, E, Koppova, K., Bueno-de-Mesquita, H.B., Ljungberg, B., Clavel-Chapelon, F., Weiderpass, E., Krogh, V., Dorronsoro, M., Travis, R.C., Tjonneland, A., Brennan, P., Chang-Claude, J., Riboli, E., Conti, D., Stern, M.C., Pike, M.C., Berg, D., Yuan, J.M., Hohensee, C., Jeppson, R.P., Cancel-Tassin, G., Roupret, M., Comperat, E., Turman, C., Vivo, I. De, Giovannucci, E., Hunter, D.J., Kraft, P., Lindstrom, S., Carta, A., Pavanello, S., Arici, C., Mastrangelo, G., Kamat, A.M., Zhang, L., Gong, Y., Pu, X., Hutchinson, A., Burdett, L., Wheeler, W.A., Karagas, M.R., and et al.

Abstract

Contains fulltext : 167299.pdf (publisher's version ) (Closed access), Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P < 1 x 10(-6)), using additional data from existing GWAS datasets and targeted genotyping for studies that did not have GWAS data. In a combined analysis, which included data on up to 15 058 cases and 286 270 controls, two SNPs achieved genome-wide statistical significance: rs6104690 in a gene desert at 20p12.2 (P = 2.19 x 10(-11)) and rs4907479 within the MCF2L gene at 13q34 (P = 3.3 x 10(-10)). Imputation and fine-mapping analyses were performed in these two regions for a subset of 5551 bladder cancer cases and 10 242 controls. Analyses at the 13q34 region suggest a single signal marked by rs4907479. In contrast, we detected two signals in the 20p12.2 region-the first signal is marked by rs6104690, and the second signal is marked by two moderately correlated SNPs (r(2) = 0.53), rs6108803 and the previously reported rs62185668. The second 20p12.2 signal is more strongly associated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stage) bladder cancer (case-case P

Published
2016

159. A Nested Case-Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Murphy, N., Cross, A.J., Abubakar, M., Jenab, M., Aleksandrova, K., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kuhn, T., Katzke, V.A., Tjonneland, A., Petersen, K.E., Overvad, K., Quiros, J.R., Jakszyn, P., Molina-Montes, E., Dorronsoro, M., Huerta, J.M., Barricarte, A., Khaw, K.T., Wareham, N., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H.B., Siersema, P.D., Peeters, P.H., Ohlsson, B., Ericson, U., Palmqvist, R., Nystrom, H., Weiderpass, E., Skeie, G., Freisling, H., Kong, S.Y., Tsilidis, K., Muller, D.C., Riboli, E., Gunter, M.J., Murphy, N., Cross, A.J., Abubakar, M., Jenab, M., Aleksandrova, K., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kuhn, T., Katzke, V.A., Tjonneland, A., Petersen, K.E., Overvad, K., Quiros, J.R., Jakszyn, P., Molina-Montes, E., Dorronsoro, M., Huerta, J.M., Barricarte, A., Khaw, K.T., Wareham, N., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H.B., Siersema, P.D., Peeters, P.H., Ohlsson, B., Ericson, U., Palmqvist, R., Nystrom, H., Weiderpass, E., Skeie, G., Freisling, H., Kong, S.Y., Tsilidis, K., Muller, D.C., Riboli, E., and Gunter, M.J.

Abstract

Contains fulltext : 165685.pdf (publisher's version ) (Open Access), BACKGROUND: Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterparts. Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown. METHODS AND FINDINGS: The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolic health/body size phenotypes were defined according to hyperinsulinaemia status using serum concentrations of C-peptide, a marker of insulin secretion. A total of 737 incident colorectal cancer cases and 737 matched controls were divided into tertiles based on the distribution of C-peptide concentration amongst the control population, and participants were classified as metabolically healthy if below the first tertile of C-peptide and metabolically unhealthy if above the first tertile. These metabolic health definitions were then combined with body mass index (BMI) measurements to create four metabolic health/body size phenotype categories: (1) metabolically healthy/normal weight (BMI < 25 kg/m2), (2) metabolically healthy/overweight (BMI >/= 25 kg/m2), (3) metabolically unhealthy/normal weight (BMI < 25 kg/m2), and (4) metabolically unhealthy/overweight (BMI >/= 25 kg/m2). Additionally, in separate models, waist circumference measurements (using the International Diabetes Federation cut-points [>/=80 cm for women and >/=94 cm for men]) were used (instead of BMI) to create the four metabolic health/body size phenotype categories. Statistical tests used in the analysis were all two-sided, and a p

Published
2016

160. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

Author

Zhang, M, Wang, Z, Obazee, O, Jia, J, Childs, EJ, Hoskins, J, Figlioli, G, Mocci, E, Collins, I, Chung, CC, Hautman, C, Arslan, AA, Beane-Freeman, L, Bracci, PM, Buring, J, Duell, EJ, Gallinger, S, Giles, GG, Goodman, GE, Goodman, PJ, Kamineni, A, Kolonel, LN, Kulke, MH, Malats, N, Olson, SH, Sesso, HD, Visvanathan, K, White, E, Zheng, W, Abnet, CC, Albanes, D, Andreotti, G, Brais, L, Bueno-de-Mesquita, HB, Basso, D, Berndt, SI, Boutron-Ruault, M-C, Bijlsma, MF, Brenner, H, Burdette, L, Campa, D, Caporaso, NE, Capurso, G, Cavestro, GM, Cotterchio, M, Costello, E, Elena, J, Boggi, U, Gaziano, JM, Gazouli, M, Giovannucci, EL, Goggins, M, Gross, M, Haiman, CA, Hassan, M, Helzlsouer, KJ, Hu, N, Hunter, DJ, Iskierka-Jazdzewska, E, Jenab, M, Kaaks, R, Key, TJ, Khaw, K-T, Klein, EA, Kogevinas, M, Krogh, V, Kupcinskas, J, Kurtz, RC, Landi, MT, Landi, S, Le Marchand, L, Mambrini, A, Mannisto, S, Milne, RL, Neale, RE, Oberg, AL, Panico, S, Patel, AV, Peeters, PHM, Peters, U, Pezzilli, R, Porta, M, Purdue, M, Ramon Quiros, J, Riboli, E, Rothman, N, Scarpa, A, Scelo, G, Shu, X-O, Silverman, DT, Soucek, P, Strobel, O, Sund, M, Malecka-Panas, E, Taylor, PR, Tavano, F, Travis, RC, Thornquist, M, Tjonneland, A, Tobias, GS, Trichopoulos, D, Vashist, Y, Vodicka, P, Wactawski-Wende, J, Wentzensen, N, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Kooperberg, C, Risch, HA, Jacobs, EJ, Li, D, Fuchs, C, Hoover, R, Hartge, P, Chanock, SJ, Petersen, GM, Stolzenberg-Solomon, RS, Wolpin, BM, Kraft, P, Klein, AP, Canzian, F, Amundadottir, LT, Zhang, M, Wang, Z, Obazee, O, Jia, J, Childs, EJ, Hoskins, J, Figlioli, G, Mocci, E, Collins, I, Chung, CC, Hautman, C, Arslan, AA, Beane-Freeman, L, Bracci, PM, Buring, J, Duell, EJ, Gallinger, S, Giles, GG, Goodman, GE, Goodman, PJ, Kamineni, A, Kolonel, LN, Kulke, MH, Malats, N, Olson, SH, Sesso, HD, Visvanathan, K, White, E, Zheng, W, Abnet, CC, Albanes, D, Andreotti, G, Brais, L, Bueno-de-Mesquita, HB, Basso, D, Berndt, SI, Boutron-Ruault, M-C, Bijlsma, MF, Brenner, H, Burdette, L, Campa, D, Caporaso, NE, Capurso, G, Cavestro, GM, Cotterchio, M, Costello, E, Elena, J, Boggi, U, Gaziano, JM, Gazouli, M, Giovannucci, EL, Goggins, M, Gross, M, Haiman, CA, Hassan, M, Helzlsouer, KJ, Hu, N, Hunter, DJ, Iskierka-Jazdzewska, E, Jenab, M, Kaaks, R, Key, TJ, Khaw, K-T, Klein, EA, Kogevinas, M, Krogh, V, Kupcinskas, J, Kurtz, RC, Landi, MT, Landi, S, Le Marchand, L, Mambrini, A, Mannisto, S, Milne, RL, Neale, RE, Oberg, AL, Panico, S, Patel, AV, Peeters, PHM, Peters, U, Pezzilli, R, Porta, M, Purdue, M, Ramon Quiros, J, Riboli, E, Rothman, N, Scarpa, A, Scelo, G, Shu, X-O, Silverman, DT, Soucek, P, Strobel, O, Sund, M, Malecka-Panas, E, Taylor, PR, Tavano, F, Travis, RC, Thornquist, M, Tjonneland, A, Tobias, GS, Trichopoulos, D, Vashist, Y, Vodicka, P, Wactawski-Wende, J, Wentzensen, N, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Kooperberg, C, Risch, HA, Jacobs, EJ, Li, D, Fuchs, C, Hoover, R, Hartge, P, Chanock, SJ, Petersen, GM, Stolzenberg-Solomon, RS, Wolpin, BM, Kraft, P, Klein, AP, Canzian, F, and Amundadottir, LT

Abstract

Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10 -15), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10 -9) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10 -8). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 ( NR5A2), chr8q24.21 ( MYC) and chr5p15.33 ( CLPTM1L- TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal ( n = 10) and tumor ( n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10 -8). This finding was validated in a second set of paired ( n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10 -4-2.0x10 -3). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.

Published
2016

161. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Author

Machiela, MJ, Zhou, W, Karlins, E, Sampson, JN, Freedman, ND, Yang, Q, Hicks, B, Dagnall, C, Hautman, C, Jacobs, KB, Abnet, CC, Aldrich, MC, Amos, C, Amundadottir, LT, Arslan, AA, Beane-Freeman, LE, Berndt, SI, Black, A, Blot, WJ, Bock, CH, Bracci, PM, Brinton, LA, Bueno-de-Mesquita, HB, Burdett, L, Buring, JE, Butler, MA, Canzian, F, Carreon, T, Chaffee, KG, Chang, I-S, Chatterjee, N, Chen, C, Chen, K, Chung, CC, Cook, LS, Bou, MC, Cullen, M, Davis, FG, De Vivo, I, Ding, T, Doherty, J, Duell, EJ, Epstein, CG, Fan, J-H, Figueroa, JD, Fraumeni, JF, Friedenreich, CM, Fuchs, CS, Gallinger, S, Gao, Y-T, Gapstur, SM, Garcia-Closas, M, Gaudet, MM, Gaziano, JM, Giles, GG, Gillanders, EM, Giovannucci, EL, Goldin, L, Goldstein, AM, Haiman, CA, Hallmans, G, Hankinson, SE, Harris, CC, Henriksson, R, Holly, EA, Hong, Y-C, Hoover, RN, Hsiung, CA, Hu, N, Hu, W, Hunter, DJ, Hutchinson, A, Jenab, M, Johansen, C, Khaw, K-T, Kim, HN, Kim, YH, Kim, YT, Klein, AP, Klein, R, Koh, W-P, Kolonel, LN, Kooperberg, C, Kraft, P, Krogh, V, Kurtz, RC, LaCroix, A, Lan, Q, Landi, MT, Le Marchand, L, Li, D, Liang, X, Liao, LM, Lin, D, Liu, J, Lissowska, J, Lu, L, Magliocco, AM, Malats, N, Matsuo, K, McNeill, LH, McWilliams, RR, Melin, BS, Mirabello, L, Moore, L, Olson, SH, Orlow, I, Park, JY, Patino-Garcia, A, Peplonska, B, Peters, U, Petersen, GM, Pooler, L, Prescott, J, Prokunina-Olsson, L, Purdue, MP, Qiao, Y-L, Rajaraman, P, Real, FX, Riboli, E, Risch, HA, Rodriguez-Santiago, B, Ruder, AM, Savage, SA, Schumacher, F, Schwartz, AG, Schwartz, KL, Seow, A, Setiawan, VW, Severi, G, Shen, H, Sheng, X, Shin, M-H, Shu, X-O, Silverman, DT, Spitz, MR, Stevens, VL, Stolzenberg-Solomon, R, Stram, D, Tang, Z-Z, Taylor, PR, Teras, LR, Tobias, GS, Van den Berg, D, Visvanathan, K, Wacholder, S, Wang, J-C, Wang, Z, Wentzensen, N, Wheeler, W, White, E, Wiencke, JK, Wolpin, BM, Wong, MP, Wu, C, Wu, T, Wu, X, Wu, Y-L, Wunder, JS, Xia, L, Yang, HP, Yang, P-C, Yu, K, Zanetti, KA, Zeleniuch-Jacquotte, A, Zheng, W, Zhou, B, Ziegler, RG, Perez-Jurado, LA, Caporaso, NE, Rothman, N, Tucker, M, Dean, MC, Yeager, M, Chanock, SJ, Machiela, MJ, Zhou, W, Karlins, E, Sampson, JN, Freedman, ND, Yang, Q, Hicks, B, Dagnall, C, Hautman, C, Jacobs, KB, Abnet, CC, Aldrich, MC, Amos, C, Amundadottir, LT, Arslan, AA, Beane-Freeman, LE, Berndt, SI, Black, A, Blot, WJ, Bock, CH, Bracci, PM, Brinton, LA, Bueno-de-Mesquita, HB, Burdett, L, Buring, JE, Butler, MA, Canzian, F, Carreon, T, Chaffee, KG, Chang, I-S, Chatterjee, N, Chen, C, Chen, K, Chung, CC, Cook, LS, Bou, MC, Cullen, M, Davis, FG, De Vivo, I, Ding, T, Doherty, J, Duell, EJ, Epstein, CG, Fan, J-H, Figueroa, JD, Fraumeni, JF, Friedenreich, CM, Fuchs, CS, Gallinger, S, Gao, Y-T, Gapstur, SM, Garcia-Closas, M, Gaudet, MM, Gaziano, JM, Giles, GG, Gillanders, EM, Giovannucci, EL, Goldin, L, Goldstein, AM, Haiman, CA, Hallmans, G, Hankinson, SE, Harris, CC, Henriksson, R, Holly, EA, Hong, Y-C, Hoover, RN, Hsiung, CA, Hu, N, Hu, W, Hunter, DJ, Hutchinson, A, Jenab, M, Johansen, C, Khaw, K-T, Kim, HN, Kim, YH, Kim, YT, Klein, AP, Klein, R, Koh, W-P, Kolonel, LN, Kooperberg, C, Kraft, P, Krogh, V, Kurtz, RC, LaCroix, A, Lan, Q, Landi, MT, Le Marchand, L, Li, D, Liang, X, Liao, LM, Lin, D, Liu, J, Lissowska, J, Lu, L, Magliocco, AM, Malats, N, Matsuo, K, McNeill, LH, McWilliams, RR, Melin, BS, Mirabello, L, Moore, L, Olson, SH, Orlow, I, Park, JY, Patino-Garcia, A, Peplonska, B, Peters, U, Petersen, GM, Pooler, L, Prescott, J, Prokunina-Olsson, L, Purdue, MP, Qiao, Y-L, Rajaraman, P, Real, FX, Riboli, E, Risch, HA, Rodriguez-Santiago, B, Ruder, AM, Savage, SA, Schumacher, F, Schwartz, AG, Schwartz, KL, Seow, A, Setiawan, VW, Severi, G, Shen, H, Sheng, X, Shin, M-H, Shu, X-O, Silverman, DT, Spitz, MR, Stevens, VL, Stolzenberg-Solomon, R, Stram, D, Tang, Z-Z, Taylor, PR, Teras, LR, Tobias, GS, Van den Berg, D, Visvanathan, K, Wacholder, S, Wang, J-C, Wang, Z, Wentzensen, N, Wheeler, W, White, E, Wiencke, JK, Wolpin, BM, Wong, MP, Wu, C, Wu, T, Wu, X, Wu, Y-L, Wunder, JS, Xia, L, Yang, HP, Yang, P-C, Yu, K, Zanetti, KA, Zeleniuch-Jacquotte, A, Zheng, W, Zhou, B, Ziegler, RG, Perez-Jurado, LA, Caporaso, NE, Rothman, N, Tucker, M, Dean, MC, Yeager, M, and Chanock, SJ

Abstract

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.

Published
2016

163. The intake of grainfibers modulates cytokine levels in blood

Author

Chuang SC, Vermeulen R, Sharabiani MT, Sacerdote C, Fatemeh SH, Berrino F, Krogh V, Palli D, Tumino R, Athersuch TJ, Vineis P., PANICO, SALVATORE, Chuang, Sc, Vermeulen, R, Sharabiani, Mt, Sacerdote, C, Fatemeh, Sh, Berrino, F, Krogh, V, Palli, D, Panico, Salvatore, Tumino, R, Athersuch, Tj, and Vineis, P.

Published
2011

165. Circulating sex hormones and breast cancer riskfactors in postmenopausal women: reanalysis of 13 studies

Author

Endogenous Hormones, Breast Cancer Collaborative Group, Key TJ, Appleby PN, Reeves GK, Roddam AW, Helzlsouer KJ, Alberg AJ, Rollison DE, Dorgan JF, Brinton LA, Overvad K, Kaaks R, Trichopoulou A, Clavel Chapelon F, Duell EJ, Peeters PH, Rinaldi S, Fentiman IS, Dowsett M, Manjer J, Lenner P, Hallmans G, Baglietto L, English DR, Giles GG, Hopper JL, Severi G, Morris HA, Hankinson SE, Tworoger SS, Koenig K, Zeleniuch Jacquotte A, Arslan AA, Toniolo P, Shore RE, Krogh V, Micheli A, Berrino F, Barrett Connor E, Laughlin GA, Kabuto M, Akiba S, Stevens RG, Neriishi K, Land CE, Cauley JA, Lui LY, Cummings SR, Gunter MJ, Rohan TE, Strickler H.D., PANICO, SALVATORE, Endogenous, Hormone, Breast Cancer Collaborative, Group, Key, Tj, Appleby, Pn, Reeves, Gk, Roddam, Aw, Helzlsouer, Kj, Alberg, Aj, Rollison, De, Dorgan, Jf, Brinton, La, Overvad, K, Kaaks, R, Trichopoulou, A, Clavel Chapelon, F, Panico, Salvatore, Duell, Ej, Peeters, Ph, Rinaldi, S, Fentiman, I, Dowsett, M, Manjer, J, Lenner, P, Hallmans, G, Baglietto, L, English, Dr, Giles, Gg, Hopper, Jl, Severi, G, Morris, Ha, Hankinson, Se, Tworoger, S, Koenig, K, Zeleniuch Jacquotte, A, Arslan, Aa, Toniolo, P, Shore, Re, Krogh, V, Micheli, A, Berrino, F, Barrett Connor, E, Laughlin, Ga, Kabuto, M, Akiba, S, Stevens, Rg, Neriishi, K, Land, Ce, Cauley, Ja, Lui, Ly, Cummings, Sr, Gunter, Mj, Rohan, Te, and Strickler, H. D.

Published
2011

167. Educational level and risk of colorectalcancer in EPIC with specific reference to tumor location

Author

Leufkens AM, Van Duijnhoven FJ, Boshuizen HC, Siersema PD, Kunst AE, Mouw T, Tjønneland A, Olsen A, Overvad K, Boutron Ruault MC, Clavel Chapelon F, Morois S, Krogh V, Tumino R, Polidoro S, Palli D, Kaaks R, Teucher B, Pischon T, Trichopoulou A, Orfanos P, Goufa I, Peeters PH, Skeie G, Braaten T, Rodríguez L, Lujan Barroso L, Sánchez Pérez MJ, Navarro C, Barricarte A, Zackrisson S, Almquist M, Hallmans G, Palmqvist R, Tsilidis KK, Khaw KT, Wareham N, Gallo V, Jenab M, Riboli E, Bueno de Mesquita H.B., PANICO, SALVATORE, Leufkens, Am, Van Duijnhoven, Fj, Boshuizen, Hc, Siersema, Pd, Kunst, Ae, Mouw, T, Tjønneland, A, Olsen, A, Overvad, K, Boutron Ruault, Mc, Clavel Chapelon, F, Morois, S, Krogh, V, Tumino, R, Panico, Salvatore, Polidoro, S, Palli, D, Kaaks, R, Teucher, B, Pischon, T, Trichopoulou, A, Orfanos, P, Goufa, I, Peeters, Ph, Skeie, G, Braaten, T, Rodríguez, L, Lujan Barroso, L, Sánchez Pérez, Mj, Navarro, C, Barricarte, A, Zackrisson, S, Almquist, M, Hallmans, G, Palmqvist, R, Tsilidis, Kk, Khaw, Kt, Wareham, N, Gallo, V, Jenab, M, Riboli, E, and Bueno de Mesquita, H. B.

Published
2011

168. Genome-wide association study of renal cell carcinoma identifiestwo susceptibility loci on 2p21 and 11q13.3

Author

Purdue MP, Johansson M, Zelenika D, Toro JR, Scelo G, Moore LE, Prokhortchouk E, Wu X, Kiemeney LA, Gaborieau V, Jacobs KB, Chow WH, Zaridze D, Matveev V, Lubinski J, Trubicka J, Szeszenia Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Foretova L, Janout V, Boffetta P, Colt JS, Davis FG, Schwartz KL, Banks RE, Selby PJ, Harnden P, Berg CD, Hsing AW, Grubb RL 3rd, Boeing H, Vineis P, Clavel Chapelon F, Palli D, Tumino R, Krogh V, Duell EJ, Quirós JR, Sanchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Khaw KT, Allen NE, Bueno de Mesquita HB, Peeters PH, Trichopoulos D, Linseisen J, Ljungberg B, Overvad K, Tjønneland A, Romieu I, Riboli E, Mukeria A, Shangina O, Stevens VL, Thun MJ, Diver WR, Gapstur SM, Pharoah PD, Easton DF, Albanes D, Weinstein SJ, Virtamo J, Vatten L, Hveem K, Njølstad I, Tell GS, Stoltenberg C, Kumar R, Koppova K, Cussenot O, Benhamou S, Oosterwijk E, Vermeulen SH, Aben KK, van der Marel SL, Ye Y, Wood CG, Pu X, Mazur AM, Boulygina ES, Chekanov NN, Foglio M, Lechner D, Gut I, Heath S, Blanche H, Hutchinson A, Thomas G, Wang Z, Yeager M, Fraumeni JF Jr, Skryabin KG, McKay JD, Rothman N, Chanock SJ, Lathrop M, Brennan P., PANICO, SALVATORE, Purdue, Mp, Johansson, M, Zelenika, D, Toro, Jr, Scelo, G, Moore, Le, Prokhortchouk, E, Wu, X, Kiemeney, La, Gaborieau, V, Jacobs, Kb, Chow, Wh, Zaridze, D, Matveev, V, Lubinski, J, Trubicka, J, Szeszenia Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Bucur, A, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Colt, J, Davis, Fg, Schwartz, Kl, Banks, Re, Selby, Pj, Harnden, P, Berg, Cd, Hsing, Aw, Grubb RL, 3rd, Boeing, H, Vineis, P, Clavel Chapelon, F, Palli, D, Tumino, R, Krogh, V, Panico, Salvatore, Duell, Ej, Quirós, Jr, Sanchez, Mj, Navarro, C, Ardanaz, E, Dorronsoro, M, Khaw, Kt, Allen, Ne, Bueno de Mesquita, Hb, Peeters, Ph, Trichopoulos, D, Linseisen, J, Ljungberg, B, Overvad, K, Tjønneland, A, Romieu, I, Riboli, E, Mukeria, A, Shangina, O, Stevens, Vl, Thun, Mj, Diver, Wr, Gapstur, Sm, Pharoah, Pd, Easton, Df, Albanes, D, Weinstein, Sj, Virtamo, J, Vatten, L, Hveem, K, Njølstad, I, Tell, G, Stoltenberg, C, Kumar, R, Koppova, K, Cussenot, O, Benhamou, S, Oosterwijk, E, Vermeulen, Sh, Aben, Kk, van der Marel, Sl, Ye, Y, Wood, Cg, Pu, X, Mazur, Am, Boulygina, E, Chekanov, Nn, Foglio, M, Lechner, D, Gut, I, Heath, S, Blanche, H, Hutchinson, A, Thomas, G, Wang, Z, Yeager, M, Fraumeni JF, Jr, Skryabin, Kg, Mckay, Jd, Rothman, N, Chanock, Sj, Lathrop, M, and Brennan, P.

Published
2011

169. Genetic polymorphisms in 15q25 and 19q13 loci, cotininelevels, and risk of lung cancer in EPIC

Author

Timofeeva MN, McKay JD, Smith GD, Johansson M, Byrnes GB, Chabrier A, Relton C, Ueland PM, Vollset SE, Midttun Ø, Nygård O, Slimani N, Romieu I, Clavel Chapelon F, Boutron Ruault MC, Fagherazzi G, Kaaks R, Teucher B, Boeing H, Weikert C, Bueno de Mesquita HB, van Gils C, Peeters PH, Agudo A, Barricarte A, Huerta JM, Rodríguez L, Sánchez MJ, Larrañaga N, Khaw KT, Wareham N, Allen NE, Travis RC, Gallo V, Norat T, Krogh V, Masala G, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Trichopoulos D, Rasmuson T, Hallmans G, Riboli E, Vineis P, Brennan P., PANICO, SALVATORE, Timofeeva, Mn, Mckay, Jd, Smith, Gd, Johansson, M, Byrnes, Gb, Chabrier, A, Relton, C, Ueland, Pm, Vollset, Se, Midttun, Ø, Nygård, O, Slimani, N, Romieu, I, Clavel Chapelon, F, Boutron Ruault, Mc, Fagherazzi, G, Kaaks, R, Teucher, B, Boeing, H, Weikert, C, Bueno de Mesquita, Hb, van Gils, C, Peeters, Ph, Agudo, A, Barricarte, A, Huerta, Jm, Rodríguez, L, Sánchez, Mj, Larrañaga, N, Khaw, Kt, Wareham, N, Allen, Ne, Travis, Rc, Gallo, V, Norat, T, Krogh, V, Masala, G, Panico, Salvatore, Sacerdote, C, Tumino, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Rasmuson, T, Hallmans, G, Riboli, E, Vineis, P, and Brennan, P.

Published
2011

170. A genome-wide association study of upperaerodigestive tract cancers conducted within the INHANCE consortium

Author

McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch Filho V, Neto JE, Garrote LF, Boccia S, Cadoni G, Arzani D, Olshan AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang SC, Zhang ZF, Wei Q, Sturgis EM, Wang LE, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit CJ, Nelson HH, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WH, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman GE, Field JK, Liloglou T, Vineis P, Clavel Chapelon F, Palli D, Tumino R, Krogh V, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno de Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Vooder T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanché H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P., PANICO, SALVATORE, Mckay, Jd, Truong, T, Gaborieau, V, Chabrier, A, Chuang, Sc, Byrnes, G, Zaridze, D, Shangina, O, Szeszenia Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Bucur, A, Bencko, V, Holcatova, I, Janout, V, Foretova, L, Lagiou, P, Trichopoulos, D, Benhamou, S, Bouchardy, C, Ahrens, W, Merletti, F, Richiardi, L, Talamini, R, Barzan, L, Kjaerheim, K, Macfarlane, Gj, Macfarlane, Tv, Simonato, L, Canova, C, Agudo, A, Castellsagué, X, Lowry, R, Conway, Di, Mckinney, Pa, Healy, Cm, Toner, Me, Znaor, A, Curado, Mp, Koifman, S, Menezes, A, Wünsch Filho, V, Neto, Je, Garrote, Lf, Boccia, S, Cadoni, G, Arzani, D, Olshan, Af, Weissler, Mc, Funkhouser, Wk, Luo, J, Lubiński, J, Trubicka, J, Lener, M, Oszutowska, D, Schwartz, Sm, Chen, C, Fish, S, Doody, Dr, Muscat, Je, Lazarus, P, Gallagher, Cj, Chang, Sc, Zhang, Zf, Wei, Q, Sturgis, Em, Wang, Le, Franceschi, S, Herrero, R, Kelsey, Kt, Mcclean, Md, Marsit, Cj, Nelson, Hh, Romkes, M, Buch, S, Nukui, T, Zhong, S, Lacko, M, Manni, Jj, Peters, Wh, Hung, Rj, Mclaughlin, J, Vatten, L, Njølstad, I, Goodman, Ge, Field, Jk, Liloglou, T, Vineis, P, Clavel Chapelon, F, Palli, D, Tumino, R, Krogh, V, Panico, Salvatore, González, Ca, Quirós, Jr, Martínez, C, Navarro, C, Ardanaz, E, Larrañaga, N, Khaw, Kt, Key, T, Bueno de Mesquita, Hb, Peeters, Ph, Trichopoulou, A, Linseisen, J, Boeing, H, Hallmans, G, Overvad, K, Tjønneland, A, Kumle, M, Riboli, E, Välk, K, Vooder, T, Metspalu, A, Zelenika, D, Boland, A, Delepine, M, Foglio, M, Lechner, D, Blanché, H, Gut, Ig, Galan, P, Heath, S, Hashibe, M, Hayes, Rb, Boffetta, P, Lathrop, M, and Brennan, P.

Published
2011

171. Postmenopausalserum sex steroids and risk of hormone receptor-positive and -negative breastcancer: a nested case-control study

Author

James RE, Lukanova A, Dossus L, Becker S, Rinaldi S, Tjønneland A, Olsen A, Overvad K, Mesrine S, Engel P, Clavel Chapelon F, Chang Claude J, Vrieling A, Boeing H, Schütze M, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Krogh V, Tumino R, Sacerdote C, Rodríguez L, Buckland G, Sánchez MJ, Amiano P, Ardanaz E, Bueno de Mesquita B, Ros MM, van Gils CH, Peeters PH, Khaw KT, Wareham N, Key TJ, Allen NE, Romieu I, Siddiq A, Cox D, Riboli E, Kaaks R., PANICO, SALVATORE, James, Re, Lukanova, A, Dossus, L, Becker, S, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Mesrine, S, Engel, P, Clavel Chapelon, F, Chang Claude, J, Vrieling, A, Boeing, H, Schütze, M, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Krogh, V, Panico, Salvatore, Tumino, R, Sacerdote, C, Rodríguez, L, Buckland, G, Sánchez, Mj, Amiano, P, Ardanaz, E, Bueno de Mesquita, B, Ros, Mm, van Gils, Ch, Peeters, Ph, Khaw, Kt, Wareham, N, Key, Tj, Allen, Ne, Romieu, I, Siddiq, A, Cox, D, Riboli, E, and Kaaks, R.

Published
2011

172. Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigationinto Cancer and Nutrition

Author

Vrieling A, Bueno de Mesquita HB, Boshuizen HC, Michaud DS, Severinsen MT, Overvad K, Olsen A, Tjønneland A, Clavel Chapelon F, Boutron Ruault MC, Kaaks R, Rohrmann S, Boeing H, Nöthlings U, Trichopoulou A, Moutsiou E, Dilis V, Palli D, Krogh V, Tumino R, Vineis P, van Gils CH, Peeters PH, Lund E, Gram IT, Rodríguez L, Agudo A, Larrañaga N, Sánchez MJ, Navarro C, Barricarte A, Manjer J, Lindkvist B, Sund M, Ye W, Bingham S, Khaw KT, Roddam A, Key T, Boffetta P, Duell EJ, Jenab M, Gallo V, Riboli E., PANICO, SALVATORE, Vrieling, A, Bueno de Mesquita, Hb, Boshuizen, Hc, Michaud, D, Severinsen, Mt, Overvad, K, Olsen, A, Tjønneland, A, Clavel Chapelon, F, Boutron Ruault, Mc, Kaaks, R, Rohrmann, S, Boeing, H, Nöthlings, U, Trichopoulou, A, Moutsiou, E, Dilis, V, Palli, D, Krogh, V, Panico, Salvatore, Tumino, R, Vineis, P, van Gils, Ch, Peeters, Ph, Lund, E, Gram, It, Rodríguez, L, Agudo, A, Larrañaga, N, Sánchez, Mj, Navarro, C, Barricarte, A, Manjer, J, Lindkvist, B, Sund, M, Ye, W, Bingham, S, Khaw, Kt, Roddam, A, Key, T, Boffetta, P, Duell, Ej, Jenab, M, Gallo, V, and Riboli, E.

Published
2010

173. Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids

Author

Thomas Vaissière, Cyrille Cuenin, Anupam Paliwal, Paolo Vineis, Hoek, G., Krzyzanowski, M., Airoldi, L., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Kim Overvad, Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Hb Bueno-De-Mesquita, Ph Peeters, Kumle, M., Ca Gonzalez, Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Jr Quiros, Berglund, G., Janzon, L., Jarvholm, B., Ne Day, Tj Key, Saracci, R., Kaaks, R., Riboli, E., Pierre Hainaut, Zdenko Herceg, Vaissière, T, Cuenin, C, Paliwal, A, Vineis, P, Hoek, G, Krzyzanowski, M, Airoldi, L, Dunning, A, Garte, S, Hainaut, P, Malaveille, C, Overvad, K, Clavel Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Trichopoulos, D, Kaladidi, A, Palli, D, Krogh, V, Tumino, R, Panico, Salvatore, Bueno De Mesquita, Hb, Peeters, Ph, Kumle, M, Gonzalez, Ca, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quiros, Jr, Berglund, G, Janzon, L, Jarvholm, B, Day, Ne, Key, Tj, Saracci, R, Kaaks, R, Riboli, E, Herceg, Z., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Subjects
Cancer Research, Lung Neoplasms, Computational biology, Biology, chemistry.chemical_compound, Humans, Methylated DNA immunoprecipitation, Biomarker discovery, Promoter Regions, Genetic, Molecular Biology, Methylenetetrahydrofolate Reductase (NADPH2), Adaptor Proteins, Signal Transducing, Genome, Human, Genes, p16, Tumor Suppressor Proteins, Multiple displacement amplification, Nuclear Proteins, Methylation, DNA Methylation, Molecular biology, Body Fluids, Long Interspersed Nucleotide Elements, chemistry, DNA methylation, Pyrosequencing, Illumina Methylation Assay, CpG Islands, MutL Protein Homolog 1, Nucleic Acid Amplification Techniques, DNA
Abstract

Udgivelsesdato: 2009-May-24 Cell-free circulating DNA isolated from the plasma of individuals with cancer has been shown to harbor cancer-associated changes in DNA methylation, and thus it represents an attractive target for biomarker discovery. However, the reliable detection of DNA methylation changes in body fluids has proven to be technically challenging. Here we describe a novel combination of methods that allows quantitative and sensitive detection of DNA methylation in minute amounts of DNA present in body fluids (quantitative Methylation Analysis of Minute DNA amounts after whole Bisulfitome Amplification, qMAMBA). This method involves genome-wide amplification of bisulphite-modified DNA template followed by quantitative methylation detection using pyrosequencing and allows analysis of multiple genes from a small amount of starting DNA. To validate our method we used qMAMBA assays for four genes and LINE1 repetitive sequences combined with plasma DNA samples as a model system. qMAMBA offered high efficacy in the analysis of methylation levels and patterns in plasma samples with extremely small amounts of DNA and low concentrations of methylated alleles. Therefore, qMAMBA will facilitate methylation studies aiming to discover epigenetic biomarkers, and should prove particularly valuable in profiling a large sample series of body fluids from molecular epidemiology studies as well as in tracking disease in early diagnostics.

Published
2009

174. Healthy lifestyle and risk of breast cancer among postmenopausal women in the European Prospective Investigation into Cancer and Nutrition cohort study

Author

Mckenzie, F, Ferrari, P, Freisling, H, Chajès, V, Rinaldi, S, de Batlle, J, Dahm, CC, Overvad, K, Baglietto, L, Dartois, L, Dossus, L, Lagiou, P, Trichopoulos, D, Trichopoulou, A, Krogh, V, Panico, S, Tumino, R, Rosso, S, Bueno-de-Mesquita, HB, May, A, Peeters, PH, Weiderpass, E, Buckland, G, Sanchez, M-J, Navarro, C, Ardanaz, E, Andersson, A, Sund, M, Ericson, U, Wirfält, E, Key, TJ, Travis, RC, Gunter, M, Riboli, E, Vergnaud, A-C, Romieu, I, Mckenzie, Fiona, Ferrari, Pietro, Freisling, Heinz, Chajès, Veronique, Rinaldi, Sabina, de Batlle, Jordi, Dahm, Christina C, Overvad, Kim, Baglietto, Laura, Dartois, Laureen, Dossus, Laure, Lagiou, Pagona, Trichopoulos, Dimitrio, Trichopoulou, Antonia, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Rosso, Stefano, Bueno de Mesquita, H. B. A, May, Anne, Peeters, Petra H, Weiderpass, Elisabete, Buckland, Genevieve, Sanchez, Maria Jose, Navarro, Carmen, Ardanaz, Eva, Andersson, Anne, Sund, Malin, Ericson, Ulrika, Wirfält, Elisabet, Key, Tim J, Travis, Ruth C, Gunter, Marc, Riboli, Elio, Vergnaud, Anne Claire, and Romieu, Isabelle

Subjects
b reast cancer, Europe, healthy index, lifestyle, prospective studies, Medicine (all), Oncology, Cancer Research, MEXICAN WOMEN, DIETARY FIBER, Alcohol Drinking, Health Status, prospective studie, European Continental Ancestry Group, Breast Neoplasms, White People, Health Statu, breast cancer, ADHERENCE, Risk Factors, Journal Article, Humans, CORONARY-HEART-DISEASE, Prospective Studies, Oncology & Carcinogenesis, Exercise, Life Style, METAANALYSIS, Science & Technology, Anthropometry, Risk Factor, Research Support, Non-U.S. Gov't, ASSOCIATION, Middle Aged, PREVENTION, Diet, Postmenopause, GLYCEMIC INDEX, Women's Health, Female, CIGARETTE-SMOKING, FATTY-ACIDS, Life Sciences & Biomedicine, Risk Reduction Behavior, 1112 Oncology And Carcinogenesis, Breast Neoplasm, Human
Abstract

Breast cancer is the most common cancer among women and prevention strategies are needed to reduce incidence worldwide. A healthy lifestyle index score (HLIS) was generated to investigate the joint effect of modifiable lifestyle factors on postmenopausal breast cancer risk. The study included 242,918 postmenopausal women from the multinational European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, with detailed information on diet and lifestyle assessed at baseline. The HLIS was constructed from five factors (diet, physical activity, smoking, alcohol consumption and anthropometry) by assigning scores of 0-4 to categories of each component, for which higher values indicate healthier behaviours. Hazard ratios (HR) were estimated by Cox proportional regression models. During 10.9 years of median follow-up, 7,756 incident breast cancer cases were identified. There was a 3% lower risk of breast cancer per point increase of the HLIS. Breast cancer risk was inversely associated with a high HLIS when fourth versus second (reference) categories were compared [adjusted HR=0.74; 95% confidence interval (CI): 0.66-0.83]. The fourth versus the second category of the HLIS was associated with a lower risk for hormone receptor double positive (adjusted HR=0.81, 95% CI: 0.67-0.98) and hormone receptor double negative breast cancer (adjusted HR=0.60, 95% CI: 0.40-0.90). Findings suggest having a high score on an index of combined healthy behaviours reduces the risk of developing breast cancer among postmenopausal women. Programmes which engage women in long term health behaviours should be supported. What's new? How much does behavior really affect cancer risk? These authors set out to measure just that. First, they created a Healthy Lifestyle Index, which quantified five modifiable behaviors, such as smoking and physical activity. Then, using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assigned each participant a score between 0 and 4 on each of the behaviors. It turned out that with each point added to a person's Healthy Lifestyle Index score, breast cancer risk fell by 3%, suggesting that public programs to help women maintain these behaviors could be worthwhile for cancer prevention.

Published
2014

175. Genome-wide association study identifies multiple loci associated with bladder cancer risk

Author

Figueroa, JD, Ye, Y, Siddiq, A, Garcia-Closas, M, Chatterjee, N, Prokunina-Olsson, L, Cortessis, VK, Kooperberg, C, Cussenot, O, Benhamou, S, Prescott, J, Porru, S, Dinney, CP, Malats, N, Baris, D, Purdue, M, Jacobs, EJ, Albanes, D, Wang, Z, Deng, X, Chung, CC, Tang, W, Bueno-De-Mesquita, HB, Trichopoulos, D, Ljungberg, B, Clavel-Chapelon, F, Weiderpass, E, Krogh, V, Dorronsoro, M, Travis, R, Tjonneland, A, Brenan, P, Chang-Claude, J, Riboli, E, Conti, D, Gago Dominguez, Manuela, Stern, MC, Pike, MC, Van den Berg, D, Yuan, JM, Hohensee, C, Rodabough, R, Cancel-Tassin, G, Roupret, M, Comperat, E, Chen, C, De Vivo, I, Giovannucci, E, Hunter, DJ, Kraft, P, Lindstrom, S, Carta, A, Pavanello, S, Arici, C, Mastrangelo, G, Kamat, AM, Lerner, SP, Grossman, HB, Lin, J, Gu, J, Pu, X, Hutchinson, A, Burdette, L, Wheeler, W, Kogevinas, M, Tardon, A, Serra, C, Carrato, A, Garcia-Closas, R, Lloreta, J, Schwenn, M, Karagas, MR, Johnson, A, Schned, A, Armenti, KR, Hosain, GM, Andriole, G, Grubb, R, Black, A, Diver, WR, Gapstur, SM, Weinstein, SJ, Virtamo, J, Haiman, CA, Landi, MT, Caporaso, N, Fraumeni, JF, Vineis, P, Wu, X, Silverman, DT, Chanock, S, and Rothman, N

Subjects
Risk, Genotype, Meta-Analysis as Topic, Urinary Bladder Neoplasms, Genetic Loci, Case-Control Studies, Humans, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Genome-Wide Association Study
Abstract

Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 x 10(-5) was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 x 10(-9)) and rs907611 on 11p15.5 (P = 4.11 x 10(-8)). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 x 10(-7)) and rs4510656 on 6p22.3 (P = 6.98 x 10(-7)); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.

Published
2014

176. Folate intake and folate serum levels in men and women from two European populations: The IMMIDIET project

Author

Pounis G., Di Castelnuovo A.F., de Lorgeril M., Krogh V., Siani A., Arnout J., Cappuccio F.P., van Dongen M., Zappacosta B., Donati M.B., de Gaetano G., Iacoviello L., Buntinx F., Dagnelie P.C., Lorgeril M., Sian A., Dirckxc C., Castelnuovo A.D., Dongen M., Bonanni A., Rink P., Vohnout B., Zito F. European Collaborative Group of the IMMIDIET Project., Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, and RS: CAPHRI - Nutritional and Molecular Epidemiology

Subjects
Adult, Male, medicine.medical_specialty, Folate, Endocrinology, Diabetes and Metabolism, UNITED-STATES, Nutritional Status, FOLIC-ACID, Folic Acid Deficiency, SUPPLEMENTATION, Nutrition Policy, Food group, Folic Acid, Sex Factors, Internal medicine, Surveys and Questionnaires, medicine, Prevalence, media_common.cataloged_instance, Humans, Folate intake, European union, Dietary patterns, media_common, Nutrition and Dietetics, business.industry, FRUIT, Dietary intake, Smoking, Dietary pattern, Middle Aged, Folate status, Cardiovascular disease, CANCER, United Kingdom, Diet, B vitamins, ENERGY-INTAKE, Endocrinology, Italy, Neurovascular disease, Dietary Reference Intake, CARDIOVASCULAR-DISEASE, Childbearing age, HOMOCYSTEINE CONCENTRATIONS, B-VITAMINS, Female, business, Demography
Abstract

Objective: Folate status has been associated with neural tube defects and cerebrovascular disease. The aim of this study was to evaluate possible differences in folate status in two European Union countries and to assess their possible association with dietary patterns and/or other lifestyles. Methods: In the framework of the European Union-funded IMMIDIET Project, 1068 individuals (534 male-female pairs), ages 26 to 64 y, were enrolled in Italy and the United Kingdom. One-year-recall food frequency questionnaire was used to evaluate dietary intake. Reduced rank regression analysis was used to derive a dietary pattern better describing high dietary folate intake. Results: Of the total participants, 11.3% of the Italians and 45.1% of the British exceeded the optimal dietary folate intake of 400 mg/d (Recommended Dietary Allowance). Of the women, 66.7% and 22.1% of Italian and British women, respectively, all at childbearing age, had folate serum levels 0; P < 0.001): 100 mg/d increase in dietary folate intake was associated with 13.8% and 10.5% increase in folate serum levels in the Italian and British population, respectively (for 100 mg/d increase eb-coef ¼ 1.138 and 1.105; P < 0.001). Smoking habit was negatively but physical activity positively associated with folate serum levels (P < 0.05). Conclusions: An inadequate dietary folate intake and subsequent serum levels were observed in the Italian participants. High consumption of food sources of folate was positively associated with folate serum levels, explaining a good proportion of its variability.

Published
2014

177. Effects of long-term exposure to air pollution on natural-cause mortality: An analysis of 22 European cohorts within the multicentre ESCAPE project

Author

Beelen, R. Raaschou-Nielsen, O. Stafoggia, M. Andersen, Z.J. Weinmayr, G. Hoffmann, B. Wolf, K. Samoli, E. Fischer, P. Nieuwenhuijsen, M. Vineis, P. Xun, W.W. Katsouyanni, K. Dimakopoulou, K. Oudin, A. Forsberg, B. Modig, L. Havulinna, A.S. Lanki, T. Turunen, A. Oftedal, B. Nystad, W. Nafstad, P. De Faire, U. Pedersen, N.L. Östenson, C.-G. Fratiglioni, L. Penell, J. Korek, M. Pershagen, G. Eriksen, K.T. Overvad, K. Ellermann, T. Eeftens, M. Peeters, P.H. Meliefste, K. Wang, M. Bueno-De-Mesquita, B. Sugiri, D. Krämer, U. Heinrich, J. De Hoogh, K. Key, T. Peters, A. Hampel, R. Concin, H. Nagel, G. Ineichen, A. Schaffner, E. Probst-Hensch, N. Künzli, N. Schindler, C. Schikowski, T. Adam, M. Phuleria, H. Vilier, A. Clavel-Chapelon, F. Declercq, C. Grioni, S. Krogh, V. Tsai, M.-Y. Ricceri, F. Sacerdote, C. Galassi, C. Migliore, E. Ranzi, A. Cesaroni, G. Badaloni, C. Forastiere, F. Tamayo, I. Amiano, P. Dorronsoro, M. Katsoulis, M. Trichopoulou, A. Brunekreef, B. Hoek, G.

Abstract

Background Few studies on long-term exposure to air pollution and mortality have been reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (ESCAPE), we aimed to investigate the association between natural-cause mortality and long-term exposure to several air pollutants. Methods We used data from 22 European cohort studies, which created a total study population of 367 251 participants. All cohorts were general population samples, although some were restricted to one sex only. With a strictly standardised protocol, we assessed residential exposure to air pollutants as annual average concentrations of particulate matter (PM) with diameters of less than 2.5 μm (PM2.5), less than 10 μm (PM 10), and between 10 μm and 2.5 μm (PMcoarse), PM2.5 absorbance, and annual average concentrations of nitrogen oxides (NO2 and NOx) with land use regression models. We also investigated two traffic intensity variables-traffic intensity on the nearest road (vehicles per day) and total traffic load on all major roads within a 100 m buffer. We did cohort-specific statistical analyses using confounder models with increasing adjustment for confounder variables, and Cox proportional hazards models with a common protocol. We obtained pooled effect estimates through a random-effects metaanalysis. Findings The total study population consisted of 367 251 participants who contributed 5 118 039 person-years at risk (average follow-up 13.9 years), of whom 29 076 died from a natural cause during follow-up. A significantly increased hazard ratio (HR) for PM2.5 of 1.07 (95% CI 1.02-1.13) per 5 μg/m3 was recorded. No heterogeneity was noted between individual cohort effect estimates (I2 p value=0.95). HRs for PM2.5 remained significantly raised even when we included only participants exposed to pollutant concentrations lower than the European annual mean limit value of 25 μg/m3 (HR 1.06, 95% CI 1.00-1.12) or below 20 μg/m3 (1.07, 1.01-1.13). Interpretation Long-term exposure to fine particulate air pollution was associated with natural-cause mortality, even within concentration ranges well below the present European annual mean limit value.

Published
2014

178. Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort

Author

Hosnijeh, F.S. Lan, Q. Rothman, N. Liu, C.S. Cheng, W.-L. Nieters, A. Guldberg, P. Tjønneland, A. Campa, D. Martino, A. Boeing, H. Trichopoulou, A. Lagiou, P. Trichopoulos, D. Krogh, V. Tumino, R. Panico, S. Masala, G. Weiderpass, E. Castanõ, J.M.H. Ardanaz, E. Sala, N. Dorronsoro, M. Quirós, J.R. Sánchez, M.-J. Melin, B. Johansson, A.S. Malm, J. Borgquist, S. Peeters, P.H. Bueno-De-Mesquita, H.B. Wareham, N. Khaw, K.-T. Travis, R.C. Brennan, P. Siddiq, A. Riboli, E. Vineis, P. Vermeulen, R.

Subjects
hemic and lymphatic diseases
Abstract

It has been suggested that mitochondrial dysfunction and DNA damage are involved in lymphomagenesis. Increased copy number of mitochondrial DNA (mtDNA) as a compensatory mechanism of mitochondrial dysfunction previously has been associated with B-cell lymphomas, in particular chronic lymphocytic leukemia (CLL). However, current evidence is limited and based on a relatively small number of cases. Usinganested case-controlstudy, we extended these findings with a focus on subtype-specific analyses. Relative mtDNA copy number was measured in the buffy coat of prospectively collected blood of 469 lymphoma cases and 469 matched controls. The association between mtDNA copy number and the risk of developing lymphoma and histologic subtypes was examined using logistic regression models. We found no overall association between mtDNA and risk of lymphoma. Subtype analyses revealed significant increased risks of CLL (n = 102) with increasing mtDNA copy number (odds ratio = 1.34, 1.44, and 1.80 for quartiles 2-4, respectively; Ptrend = .001). mtDNA copy number was not associated with follow-up time, suggesting that this observation is not strongly influenced by indolent disease status. This study substantially strengthens the evidence that mtDNA copy number is related to risk of CLL and supports the importance of mitochondrial dysfunction as a possible mechanistic pathway in CLL ontogenesis. © 2014 by The American Society of Hematology.

Published
2014

179. Functional foods and cardiometabolic diseases : International Task Force for Prevention of Cardiometabolic Diseases

Author

Assman, G., Buono, P., Della Valle, E., Farinaro, E., Ferns, G., Krogh, V., and Kromhout, D.

Subjects
Nutrition and Disease, cardiovascular risk-factors, vitamin-e, dietary fiber intake, fish consumption, density-lipoprotein cholesterol, plant sterols, n-3 fatty-acids, stanol ester consumption, Voeding en Ziekte, randomized controlled-trial, coronary-heart-disease, VLAG
Abstract

Mounting evidence supports the hypothesis that functional foods containing physiologically-active components may be healthful. Longitudinal cohort studies have shown that some food classes and dietary patterns are beneficial in primary prevention, and this has led to the identification of putative functional foods. This field, however, is at its very beginning, and additional research is necessary to substantiate the potential health benefit of foods for which the diet–health relationships are not yet scientifically validated. It appears essential, however, that before health claims are made for particular foods, in vivo randomized, double-blind, placebo-controlled trials of clinical end-points are necessary to establish clinical efficacy. Since there is need for research work aimed at devising personalized diet based on genetic make-up, it seems more than reasonable the latter be modeled, at present, on the Mediterranean diet, given the large body of evidence of its healthful effects. The Mediterranean diet is a nutritional model whose origins go back to the traditional diet adopted in European countries bordering the Mediterranean sea, namely central and southern Italy, Greece and Spain; these populations have a lower incidence of cardiovascular diseases than the North American ones, whose diet is characterized by high intake of animal fat. The meeting in Naples and this document both aim to focus on the changes in time in these two different models of dietary habits and their fall out on public health.

Published
2014

180. Long-term exposure to air pollution and cardiovascular mortality: An analysis of 22 European cohorts

Author

Beelen, R. Stafoggia, M. Raaschou-Nielsen, O. Andersen, Z.J. Xun, W.W. Katsouyanni, K. Dimakopoulou, K. Brunekreef, B. Weinmayr, G. Hoffmann, B. Wolf, K. Samoli, E. Houthuijs, D. Nieuwenhuijsen, M. Oudin, A. Forsberg, B. Olsson, D. Salomaa, V. Lanki, T. Yli-Tuomi, T. Oftedal, B. Aamodt, G. Nafstad, P. De Faire, U. Pedersen, N.L. Östenson, C.-G. Fratiglioni, L. Penell, J. Korek, M. Pyko, A. Eriksen, K.T. Tjønneland, A. Becker, T. Eeftens, M. Bots, M. Meliefste, K. Wang, M. Bueno-De-Mesquita, B. Sugiri, D. Krämer, U. Heinrich, J. De Hoogh, K. Key, T. Peters, A. Cyrys, J. Concin, H. Nagel, G. Ineichen, A. Schaffner, E. Probst-Hensch, N. Dratva, J. Ducret-Stich, R. Vilier, A. Clavel-Chapelon, F. Stempfelet, M. Grioni, S. Krogh, V. Tsai, M.-Y. Marcon, A. Ricceri, F. Sacerdote, C. Galassi, C. Migliore, E. Ranzi, A. Cesaroni, G. Badaloni, C. Forastiere, F. Tamayo, I. Amiano, P. Dorronsoro, M. Katsoulis, M. Trichopoulou, A. Vineis, P. Hoek, G.

Abstract

Background: Air pollution has been associated with cardiovascular mortality, but it remains unclear as to whether specific pollutants are related to specific cardiovascular causes of death. Within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE), we investigated the associations of long-term exposure to several air pollutants with all cardiovascular disease (CVD) mortality, as well as with specific cardiovascular causes of death. Methods: Data from 22 European cohort studies were used. Using a standardized protocol, study area-specific air pollution exposure at the residential address was characterized as annual average concentrations of the following: nitrogen oxides (NO2and NOx); particles with diameters of less than 2.5 μm (PM2.5), less than 10 μm (PM10), and 10 μm to 2.5 μm (PMcoarse); PM2.5absorbance estimated by land-use regression models; and traffic indicators. We applied cohort-specific Cox proportional hazards models using a standardized protocol. Random-effects meta-analysis was used to obtain pooled effect estimates. Results: The total study population consisted of 367,383 participants, with 9994 deaths from CVD (including 4,992 from ischemic heart disease, 2264 from myocardial infarction, and 2484 from cerebrovascular disease). All hazard ratios were approximately 1.0, except for particle mass and cerebrovascular disease mortality; for PM2.5, the hazard ratio was 1.21 (95% confidence interval = 0.87-1.69) per 5 μg/m and for PM10, 1.22 (0.91-1.63) per 10 μg/m. Conclusion: In a joint analysis of data from 22 European cohorts, most hazard ratios for the association of air pollutants with mortality from overall CVD and with specific CVDs were approximately 1.0, with the exception of particulate mass and cerebrovascular disease mortality for which there was suggestive evidence for an association. Copyright © 2014 by Lippincott Williams & Wilkins.

Published
2014

182. Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: a cross-sectional study within the EPIC cohort

Author

Rinaldi, S. Kaaks, R. Friedenreich, C. M. Key, T. J. and Travis, R. Biessy, C. Slimani, N. Overvad, K. and Ostergaard, J. N. Tjonneland, A. Olsen, A. Mesrine, S. and Fournier, A. Dossus, L. Lukanova, A. Johnson, T. Boeing, H. Vigl, M. Trichopoulou, A. Benetou, V. Trichopoulos, D. Masala, G. Krogh, V. Tumino, R. Ricceri, F. and Panico, S. Bueno-de-Mesquita, H. B. Monninkhof, E. M. May, A. M. Weiderpass, E. Quiros, J. R. Travier, N. and Molina-Montes, E. Amiano, P. Huerta, J. M. Ardanaz, E. and Sund, M. Johansson, M. Khaw, K. T. Wareham, N. Scalbert, A. Gunter, M. J. Riboli, E. Romieu, I.

Abstract

Increased physical activity (PA) is associated with a reduced risk of several cancers. PA may reduce cancer risk by changing endogenous hormones levels, but relatively little research has focused on this topic. The purpose of this study was to elucidate the relation between PA and endogenous hormone concentrations. A cross-sectional analysis of 798 pre- and 1,360 post-menopausal women included as controls in case-control studies on endogenous hormones (steroids, progesterone, sex-hormone-binding globulin (SHBG), and growth factors) levels, and cancer risk nested within European Prospective Investigation into Cancer and Nutrition cohort was performed. Multivariate regression analyses were performed to compare geometric mean levels of hormones and SHBG by categories of PA. In pre-menopausal women, active women had 19 % significantly lower concentrations of androstenedione, 14 % lower testosterone, and 20 % lower free testosterone than inactive women, while no differences were observed for estrogens, progesterone, SHBG, and growth factors. In post-menopausal women, active women had 18 % significantly lower estradiol and 20 % lower free estradiol concentrations than inactive women, while no differences were observed for the other hormones and SHBG. More vigorous forms of physical activity were associated with higher insulin-like growth factor-I concentrations. Adjustment for body mass index did not alter the associations. Overall, the percentage of variance in hormone concentrations explained by PA levels was < 2 %. Our results support the hypothesis of an influence, although small in magnitude, of PA on sex hormone levels in blood, independent of body size.

Published
2014

183. Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabeticpopulation

Author

Nöthlings U, Schulze MB, Weikert C, Boeing H, van der Schouw YT, Bamia C, Benetou V, Lagiou P, Krogh V, Beulens JW, Peeters PH, Halkjaer J, Tjønneland A, Tumino R, Masala G, Clavel Chapelon F, de Lauzon B, Boutron Ruault MC, Vercambre MN, Kaaks R, Linseisen J, Overvad K, Arriola L, Ardanaz E, Gonzalez CA, Tormo MJ, Bingham S, Khaw KT, Key TJ, Vineis P, Riboli E, Ferrari P, Boffetta P, Bueno de Mesquita HB, van der A. DL, Berglund G, Wirfält E, Hallmans G, Johansson I, Lund E, Trichopoulo A., PANICO, SALVATORE, Nöthlings, U, Schulze, Mb, Weikert, C, Boeing, H, van der Schouw, Yt, Bamia, C, Benetou, V, Lagiou, P, Krogh, V, Beulens, Jw, Peeters, Ph, Halkjaer, J, Tjønneland, A, Tumino, R, Panico, Salvatore, Masala, G, Clavel Chapelon, F, de Lauzon, B, Boutron Ruault, Mc, Vercambre, Mn, Kaaks, R, Linseisen, J, Overvad, K, Arriola, L, Ardanaz, E, Gonzalez, Ca, Tormo, Mj, Bingham, S, Khaw, Kt, Key, Tj, Vineis, P, Riboli, E, Ferrari, P, Boffetta, P, Bueno de Mesquita, Hb, van der A., Dl, Berglund, G, Wirfält, E, Hallmans, G, Johansson, I, Lund, E, and Trichopoulo, A.

Published
2008

184. Dietary fat and breast cancer risk in the European ProspectiveInvestigation into Cancer and Nutrition

Author

Sieri S, Krogh V, Ferrari P, Berrino F, Pala V, Thiébaut AC, Tjønneland A, Olsen A, Overvad K, Jakobsen MU, Clavel Chapelon F, Chajes V, Boutron Ruault MC, Kaaks R, Linseisen J, Boeing H, Nöthlings U, Trichopoulou A, Naska A, Lagiou P, Palli D, Vineis P, Tumino R, Lund E, Kumle M, Skeie G, González CA, Ardanaz E, Amiano P, Tormo MJ, Martínez García C, Quirós JR, Berglund G, Gullberg B, Hallmans G, Lenner P, Bueno de Mesquita HB, van Duijnhoven FJ, Peeters PH, van Gils CH, Key TJ, Crowe FL, Bingham S, Khaw KT, Rinaldi S, Slimani N, Jenab M, Norat T, Riboli E., PANICO, SALVATORE, Sieri, S, Krogh, V, Ferrari, P, Berrino, F, Pala, V, Thiébaut, Ac, Tjønneland, A, Olsen, A, Overvad, K, Jakobsen, Mu, Clavel Chapelon, F, Chajes, V, Boutron Ruault, Mc, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Trichopoulou, A, Naska, A, Lagiou, P, Panico, Salvatore, Palli, D, Vineis, P, Tumino, R, Lund, E, Kumle, M, Skeie, G, González, Ca, Ardanaz, E, Amiano, P, Tormo, Mj, Martínez García, C, Quirós, Jr, Berglund, G, Gullberg, B, Hallmans, G, Lenner, P, Bueno de Mesquita, Hb, van Duijnhoven, Fj, Peeters, Ph, van Gils, Ch, Key, Tj, Crowe, Fl, Bingham, S, Khaw, Kt, Rinaldi, S, Slimani, N, Jenab, M, Norat, T, and Riboli, E.

Published
2008

185. Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Author

Jakszyn, P., Bingham, S., Pera, G., Agudo, A., Luben, R., Welch, A., Boeing, H., Del Giudice, G., Palli, D., Saieva, C., Krogh, V., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Hallmans, G., Mj, Sanchez, Larranaga, N., Barricarte, A., Md, Chirlaque, Jr, Quiros, Tj, Key, Carneiro, F., Allen, N., Linseisen, J., Nagel, G., Kim Overvad, Anne Tjønneland, Anja Viendahl Olsen, Hb, Bueno-De-Mesquita, Mo, Ocke, Ph, Peeters, Me, Numans, Clavel-Chapelon, F., Trichopoulou, A., Fenger, C., Stenling, R., Ferrari, P., Jenab, M., Norat, T., Riboli, E., Ca, Gonzalez, Lund, E., Jakszyn, P, Bingham, S, Pera, G, Agudo, A, Luben, R, Welch, A, Boeing, H, Del, Giudice, G, Palli, D, Saieva, C, Krogh, V, Sacerdote, C, Tumino, R, Panico, Salvatore, Berglund, G, Siman, H, Hallmans, G, Sanchez, Mj, Larranaga, N, Barricarte, A, Chirlaque, Md, Quiros, Jr, Key, Tj, Allen, N, Lund, E, Carneiro, F, Linseisen, J, Nagel, G, Overvad, K, Tjonneland, A, Olsen, A, BUENO DE MESQUITA, Hb, Ocke, Mo, Peeters, Ph, Numans, Me, CLAVEL CHAPELON, F, Trichopoulou, A, Fenger, C, Stenling, R, Ferrari, P, Jenab, M, Norat, T, Riboli, E, and Gonzalez, Ca

Published
2006

186. Erratum: Amount of DNA in plasma and cancer risk: A prospective study (International Journal of Cancer (2004) 111 (746-749))

Author

Gormally, E., Hainaut, P., Caboux, E., Airoldi, L., Autrup, H., Malaveille, C., Dunning, A., Garte, S., Matullo, G., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Boffetta, P., Boeing, H., Trichopoulou, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H. B., Peeters, P. H., Lund, E., Gonzalez, C. A., Martinez, C., Dorronsoro, M., Barricarte, A., Tormo, M. J., Quiros, J. R., Berglund, G., Hallmans, G., Day, N. E., Key, T. J., Veglia, F., Peluso, M., Norat, T., Saracci, R., Kaaks, R., Riboli, E., Vineis, P., Gormally, E., Hainaut, P., Caboux, E., Airoldi, L., Autrup, H., Malaveille, C., Dunning, A., Garte, S., Matullo, G., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Boffetta, P., Boeing, H., Trichopoulou, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H.B., Peeters, P.H., Lund, E., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Tormo, M.J., Quiros, J.R., Berglund, G., Hallmans, G., Day, N.E., Key, T.J., Veglia, F., Peluso, M., Norat, T., Saracci, R., Kaaks, R., Riboli, E., and Vineis, P.

Subjects
Amount of DNA in plasma and cancer risk
Abstract

No abstract

Published
2006

187. Sex differences in food choices, adherence to dietary recommendations and plasma lipid profile in type 2 diabetes – The TOSCA.IT study

Author

Vitale, M., primary, Masulli, M., additional, Cocozza, S., additional, Anichini, R., additional, Babini, A.C., additional, Boemi, M., additional, Bonora, E., additional, Buzzetti, R., additional, Carpinteri, R., additional, Caselli, C., additional, Ceccarelli, E., additional, Cignarelli, M., additional, Citro, G., additional, Clemente, G., additional, Consoli, A., additional, Corsi, L., additional, De Gregorio, A., additional, Di Bartolo, P., additional, Di Cianni, G., additional, Fontana, L., additional, Garofolo, M., additional, Giorda, C.B., additional, Giordano, C., additional, Grioni, S., additional, Iovine, C., additional, Longhitano, S., additional, Mancastroppa, G., additional, Mazzucchelli, C., additional, Montani, V., additional, Mori, M., additional, Perriello, G., additional, Rinaldi, M.E., additional, Ruffo, M.C., additional, Salvi, L., additional, Sartore, G., additional, Scaranna, C., additional, Tonutti, L., additional, Zamboni, C., additional, Zogheri, A., additional, Krogh, V., additional, Cappellini, F., additional, Signorini, S., additional, Riccardi, G., additional, and Vaccaro, O., additional

Published
2016
Full Text
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188. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study

Author

TRICHOPOULOU A, ORFANOS P, NORAT T, BUENO DE MESQUITA B, OCKE MC, PEETERS, PH, VAN DER SCHOUW YT, BOEING H, HOFFMANN K, BOFFETTA P, NAGEL G, MASALA G, KROGH V, TUMINO R, VINEIS P, BAMIA C, NASKA A, BENETOU V, FERRARI P, SLIMANI N, PERA G, MARTINEZ GARCIA C, NAVARRO C, RODRIGUEZ BARRANCO M, DORRONSORO M, SPENCER EA, KEY TJ, BINGHAM S, KHAW KT, KESSE E, CLAVEL CHAPELON, F, BOUTRON RUAULT MC, BERGLUND G, WIRFALT E, HALLMANS G, JOHANSSON I, TJONNELAND, A, OLSEN A, OVERVAD K, HUNDBORG HH, RIBOLI E, TRICHOPOULOS D., PANICO, SALVATORE, Trichopoulou, A, Orfanos, P, Norat, T, BUENO DE MESQUITA, B, Ocke, Mc, Peeters, Ph, VAN DER SCHOUW, Yt, Boeing, H, Hoffmann, K, Boffetta, P, Nagel, G, Masala, G, Krogh, V, Panico, Salvatore, Tumino, R, Vineis, P, Bamia, C, Naska, A, Benetou, V, Ferrari, P, Slimani, N, Pera, G, MARTINEZ GARCIA, C, Navarro, C, RODRIGUEZ BARRANCO, M, Dorronsoro, M, Spencer, Ea, Key, Tj, Bingham, S, Khaw, Kt, Kesse, E, Clavel, Chapelon, F, BOUTRON RUAULT, Mc, Berglund, G, Wirfalt, E, Hallmans, G, Johansson, I, Tjonneland, A, Olsen, A, Overvad, K, Hundborg, Hh, Riboli, E, and Trichopoulos, D.

Published
2005

189. Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics : results from the EPIC cohort

Author

Ose, J., Fortner, R. T., Schock, H., Peeters, P. H., Onland-Moret, N. C., Bueno-de-Mesquita, H. B., Weiderpass, E., Gram, I. T., Overvad, K., Tjonneland, A., Dossus, L., Fournier, A., Baglietto, L., Trichopoulou, A., Benetou, V., Trichopoulos, D., Boeing, H., Masala, G., Krogh, V., Matiello, A., Tumino, R., Popovic, M., Obon-Santacana, M., Larranaga, N., Ardanaz, E., Sanchez, M-J, Menendez, V., Chirlaque, M-D, Travis, R. C., Khaw, K-T, Braendstedt, J., Idahl, Annika, Lundin, Eva, Rinaldi, S., Kuhn, E., Romieu, I., Gunter, M. J., Merritt, M. A., Riboli, E., Kaaks, R., Ose, J., Fortner, R. T., Schock, H., Peeters, P. H., Onland-Moret, N. C., Bueno-de-Mesquita, H. B., Weiderpass, E., Gram, I. T., Overvad, K., Tjonneland, A., Dossus, L., Fournier, A., Baglietto, L., Trichopoulou, A., Benetou, V., Trichopoulos, D., Boeing, H., Masala, G., Krogh, V., Matiello, A., Tumino, R., Popovic, M., Obon-Santacana, M., Larranaga, N., Ardanaz, E., Sanchez, M-J, Menendez, V., Chirlaque, M-D, Travis, R. C., Khaw, K-T, Braendstedt, J., Idahl, Annika, Lundin, Eva, Rinaldi, S., Kuhn, E., Romieu, I., Gunter, M. J., Merritt, M. A., Riboli, E., and Kaaks, R.

Abstract

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

Published
2015
Full Text
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190. Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: a nested case-control study: plasma micronutrients and pancreatic cancer risk

Author

Jeurnink, S.M., Ros, M.M., Leenders, M., Duijnhoven, F.J. van, Siersema, P.D., Jansen, E.H., Gils, C.H. van, Bakker, M.F., Overvad, K., Roswall, N., Tjonneland, A., Boutron-Ruault, M.C., Racine, A., Cadeau, C., Grote, V., Kaaks, R., Aleksandrova, K., Boeing, H., Trichopoulou, A., Benetou, V., Valanou, E., Palli, D., Krogh, V., Vineis, P., Tumino, R., Mattiello, A., Weiderpass, E., Skeie, G., Castano, J.M., Duell, E.J., Barricarte, A., Molina-Montes, E., Arguelles, M., Dorronsoro, M., Johansen, D., Lindkvist, B., Sund, M., Crowe, F.L., Khaw, K.T., Jenab, M., Fedirko, V., Riboli, E., Bueno-de-Mesquita, H.B., Jeurnink, S.M., Ros, M.M., Leenders, M., Duijnhoven, F.J. van, Siersema, P.D., Jansen, E.H., Gils, C.H. van, Bakker, M.F., Overvad, K., Roswall, N., Tjonneland, A., Boutron-Ruault, M.C., Racine, A., Cadeau, C., Grote, V., Kaaks, R., Aleksandrova, K., Boeing, H., Trichopoulou, A., Benetou, V., Valanou, E., Palli, D., Krogh, V., Vineis, P., Tumino, R., Mattiello, A., Weiderpass, E., Skeie, G., Castano, J.M., Duell, E.J., Barricarte, A., Molina-Montes, E., Arguelles, M., Dorronsoro, M., Johansen, D., Lindkvist, B., Sund, M., Crowe, F.L., Khaw, K.T., Jenab, M., Fedirko, V., Riboli, E., and Bueno-de-Mesquita, H.B.

Abstract

Item does not contain fulltext, Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (alpha- and beta-carotene, lycopene, beta-cryptoxanthin, canthaxanthin, zeaxanthin and lutein), alpha- and gamma-tocopherol and retinol were measured by reverse phase high-performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma beta-carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31-0.88, p for trend = 0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30-0.94, p for trend = 0.06) and alpha-tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39-0.99, p for trend = 0.08. For alpha- and beta-carotene, lutein, sum of carotenoids and gamma-tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of beta-carotene, zeaxanthin and alpha-tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted.

Published
2015

191. Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies

Author

Key, TJ, Appleby, PN, Reeves, GK, Travis, RC, Brinton, LA, Dallal, CM, Helzlsouer, KJ, Hoffman-Bolton, J, Visvanathan, K, Dorgan, JF, Falk, RT, Gapstur, SM, Gaudet, MM, Kaaks, R, Riboli, E, Rinaldi, S, Key, T, Manjer, J, Hallmans, G, Giles, GG, Le Marchand, L, Kolonel, LN, Henderson, BE, Tworoger, SS, Hankinson, SE, Zeleniuch-Jacquotte, A, Koenig, K, Krogh, V, Sieri, S, Muti, P, Ziegler, RG, Schairer, C, Fuhrman, BJ, Barrett-Connor, E, Laughlin, GA, Grant, EJ, Cologne, J, Ohishi, W, Hida, A, Cauley, JA, Fourkala, E-O, Rohan, TE, Strickler, HD, Gunter, MJ, Key, TJ, Appleby, PN, Reeves, GK, Travis, RC, Brinton, LA, Dallal, CM, Helzlsouer, KJ, Hoffman-Bolton, J, Visvanathan, K, Dorgan, JF, Falk, RT, Gapstur, SM, Gaudet, MM, Kaaks, R, Riboli, E, Rinaldi, S, Key, T, Manjer, J, Hallmans, G, Giles, GG, Le Marchand, L, Kolonel, LN, Henderson, BE, Tworoger, SS, Hankinson, SE, Zeleniuch-Jacquotte, A, Koenig, K, Krogh, V, Sieri, S, Muti, P, Ziegler, RG, Schairer, C, Fuhrman, BJ, Barrett-Connor, E, Laughlin, GA, Grant, EJ, Cologne, J, Ohishi, W, Hida, A, Cauley, JA, Fourkala, E-O, Rohan, TE, Strickler, HD, and Gunter, MJ

Abstract

Epidemiological studies have examined breast cancer risk in relation to sex hormone concentrations measured by different methods: "extraction" immunoassays (with prior purification by organic solvent extraction, with or without column chromatography), "direct" immunoassays (no prior extraction or column chromatography), and more recently with mass spectrometry-based assays. We describe the associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method, using data from a collaborative pooled analysis of 18 prospective studies. In general, hormone concentrations were highest in studies that used direct assays and lowest in studies that used mass spectrometry-based assays. Estradiol and estrone were strongly positively associated with body mass index, regardless of the assay method; testosterone was positively associated with body mass index for direct assays, but less clearly for extraction assays, and there were few data for mass spectrometry assays. The correlations of estradiol with body mass index, estrone and testosterone were lower for direct assays than for extraction and mass spectrometry assays, suggesting that the estimates from the direct assays were less precise. For breast cancer risk, all three hormones were strongly positively associated with risk regardless of assay method (except for testosterone by mass spectrometry where there were few data), with no statistically significant differences in the trends, but differences may emerge as new data accumulate. Future epidemiological and clinical research studies should continue to use the most accurate assays that are feasible within the design characteristics of each study.

Published
2015

192. Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study

Author

Tikk, K, Sookthai, D, Fortner, RT, Johnson, T, Rinaldi, S, Romieu, I, Tjonneland, A, Olsen, A, Overvad, K, Clavel-Chapelon, F, Baglietto, L, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Ricceri, F, Mattiello, A, Agudo, A, Menendez, V, Sanchez, M-J, Amiano, P, Chirlaque, M-D, Barricarte, A, Bueno-de-Mesquita, H, Monninkhof, EM, Onland-Moret, NC, Andresson, A, Sund, M, Weiderpass, E, Khaw, K-T, Key, TJ, Travis, RC, Merritt, MA, Riboli, E, Dossus, L, Kaaks, R, Tikk, K, Sookthai, D, Fortner, RT, Johnson, T, Rinaldi, S, Romieu, I, Tjonneland, A, Olsen, A, Overvad, K, Clavel-Chapelon, F, Baglietto, L, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Ricceri, F, Mattiello, A, Agudo, A, Menendez, V, Sanchez, M-J, Amiano, P, Chirlaque, M-D, Barricarte, A, Bueno-de-Mesquita, H, Monninkhof, EM, Onland-Moret, NC, Andresson, A, Sund, M, Weiderpass, E, Khaw, K-T, Key, TJ, Travis, RC, Merritt, MA, Riboli, E, Dossus, L, and Kaaks, R

Abstract

INTRODUCTION: The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention. METHODS: We analysed the relationship between pre-diagnostic prolactin levels and the risk of in situ breast cancer overall, and by menopausal status and use of postmenopausal hormone therapy (HT) at blood donation. Conditional logistic regression was used to assess this association in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, including 307 in situ breast cancer cases and their matched control subjects. RESULTS: We found a significant positive association between higher circulating prolactin levels and risk of in situ breast cancer among all women [pre-and postmenopausal combined, ORlog2=1.35 (95% CI 1.04-1.76), Ptrend=0.03]. No statistically significant heterogeneity was found between prolactin levels and in situ cancer risk by menopausal status (Phet=0.98) or baseline HT use (Phet=0.20), although the observed association was more pronounced among postmenopausal women using HT compared to non-users (Ptrend=0.06 vs Ptrend=0.35). In subgroup analyses, the observed positive association was strongest in women diagnosed with in situ breast tumors<4 years compared to ≥4 years after blood donation (Ptrend=0.01 vs Ptrend=0.63; Phet=0.04) and among nulliparous women compared to parous women (Ptrend=0.03 vs Ptrend=0.15; Phet=0.07). CONCLUSIONS: Our data extends prior research linking prolactin and invasive breast cancer to the outcome of in situ breast tumours and shows that higher circulating prolactin is associated with increased risk of in situ breast cancer.

Published
2015

193. Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

Author

Ose, J, Fortner, RT, Schock, H, Peeters, PH, Onland-Moret, NC, Bueno-de-Mesquita, HB, Weiderpass, E, Gram, IT, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obon-Santacana, M, Larranaga, N, Ardanaz, E, Sanchez, M-J, Menendez, V, Chirlaque, M-D, Travis, RC, Khaw, K-T, Braendstedt, J, Idahl, A, Lundin, E, Rinaldi, S, Kuhn, E, Romieu, I, Gunter, MJ, Merritt, MA, Riboli, E, Kaaks, R, Ose, J, Fortner, RT, Schock, H, Peeters, PH, Onland-Moret, NC, Bueno-de-Mesquita, HB, Weiderpass, E, Gram, IT, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obon-Santacana, M, Larranaga, N, Ardanaz, E, Sanchez, M-J, Menendez, V, Chirlaque, M-D, Travis, RC, Khaw, K-T, Braendstedt, J, Idahl, A, Lundin, E, Rinaldi, S, Kuhn, E, Romieu, I, Gunter, MJ, Merritt, MA, Riboli, E, and Kaaks, R

Abstract

BACKGROUND: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. METHODS: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. RESULTS: We observed no association between IGF-I and EOC overall or by tumour characteristics. CONCLUSIONS: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

Published
2015

194. Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS MDL 1, Ose, J., Fortner, R. T., Schock, H., Peeters, P. H., Onland-Moret, N. C., Bueno-De-Mesquita, H. B., Weiderpass, E., Gram, I. T., Overvad, K., Tjonneland, A., Dossus, L., Fournier, A., Baglietto, L., Trichopoulou, A., Benetou, V., Trichopoulos, D., Boeing, H., Masala, G., Krogh, V., Matiello, A., Tumino, R., Popovic, M., Obón-Santacana, M., Larrañaga, N., Ardanaz, E., Sánchez, M. J., Menéndez, V., Chirlaque, M. D., Travis, R. C., Khaw, K. T., Brändstedt, J., Idahl, A., Lundin, E., Rinaldi, S., Kuhn, E., Romieu, I., Gunter, M. J., Merritt, M. A., Riboli, E., Kaaks, R., Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS MDL 1, Ose, J., Fortner, R. T., Schock, H., Peeters, P. H., Onland-Moret, N. C., Bueno-De-Mesquita, H. B., Weiderpass, E., Gram, I. T., Overvad, K., Tjonneland, A., Dossus, L., Fournier, A., Baglietto, L., Trichopoulou, A., Benetou, V., Trichopoulos, D., Boeing, H., Masala, G., Krogh, V., Matiello, A., Tumino, R., Popovic, M., Obón-Santacana, M., Larrañaga, N., Ardanaz, E., Sánchez, M. J., Menéndez, V., Chirlaque, M. D., Travis, R. C., Khaw, K. T., Brändstedt, J., Idahl, A., Lundin, E., Rinaldi, S., Kuhn, E., Romieu, I., Gunter, M. J., Merritt, M. A., Riboli, E., and Kaaks, R.

Published
2015

195. Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies

Author

Key, T. J., Appleby, P. N., Reeves, G. K., Travis, R. C., Brinton, L. A., Dallal, C. M., Helzlsouer, K. J., Hoffman-Bolton, J., Visvanathan, K., Dorgan, J. F., Falk, R. T., Gapstur, S. M., Gaudet, M. M., Kaaks, R., Riboli, E., Rinaldi, S., Key, T., Manjer, Jonas, Hallmans, G., Giles, G. G., Le Marchand, L., Kolonel, L. N., Henderson, B. E., Tworoger, S. S., Hankinson, S. E., Zeleniuch-Jacquotte, A., Koenig, K., Krogh, V., Sieri, S., Muti, P., Ziegler, R. G., Schairer, C., Fuhrman, B. J., Barrett-Connor, E., Laughlin, G. A., Grant, E. J., Cologne, J., Ohishi, W., Hida, A., Cauley, J. A., Fourkala, E.-O., Rohan, T. E., Strickler, H. D., Gunter, M. J., Key, T. J., Appleby, P. N., Reeves, G. K., Travis, R. C., Brinton, L. A., Dallal, C. M., Helzlsouer, K. J., Hoffman-Bolton, J., Visvanathan, K., Dorgan, J. F., Falk, R. T., Gapstur, S. M., Gaudet, M. M., Kaaks, R., Riboli, E., Rinaldi, S., Key, T., Manjer, Jonas, Hallmans, G., Giles, G. G., Le Marchand, L., Kolonel, L. N., Henderson, B. E., Tworoger, S. S., Hankinson, S. E., Zeleniuch-Jacquotte, A., Koenig, K., Krogh, V., Sieri, S., Muti, P., Ziegler, R. G., Schairer, C., Fuhrman, B. J., Barrett-Connor, E., Laughlin, G. A., Grant, E. J., Cologne, J., Ohishi, W., Hida, A., Cauley, J. A., Fourkala, E.-O., Rohan, T. E., Strickler, H. D., and Gunter, M. J.

Abstract

Epidemiological studies have examined breast cancer risk in relation to sex hormone concentrations measured by different methods: "extraction" immunoassays (with prior purification by organic solvent extraction, with or without column chromatography), "direct" immunoassays (no prior extraction or column chromatography), and more recently with mass spectrometry-based assays. We describe the associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method, using data from a collaborative pooled analysis of 18 prospective studies. In general, hormone concentrations were highest in studies that used direct assays and lowest in studies that used mass spectrometry-based assays. Estradiol and estrone were strongly positively associated with body mass index, regardless of the assay method; testosterone was positively associated with body mass index for direct assays, but less clearly for extraction assays, and there were few data for mass spectrometry assays. The correlations of estradiol with body mass index, estrone and testosterone were lower for direct assays than for extraction and mass spectrometry assays, suggesting that the estimates from the direct assays were less precise. For breast cancer risk, all three hormones were strongly positively associated with risk regardless of assay method (except for testosterone by mass spectrometry where there were few data), with no statistically significant differences in the trends, but differences may emerge as new data accumulate. Future epidemiological and clinical research studies should continue to use the most accurate assays that are feasible within the design characteristics of each study.

Published
2015

196. Body iron status and gastric cancer risk in the EURGAST study

Author

Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Fonseca-Nunes A., Agudo A., Aranda N., Arija V., Cross A.J., Molina E., Sanchez M.J., Bueno-De-Mesquita H.B., Siersema P., Weiderpass E., Krogh V., Mattiello A., Tumino R., Saieva C., Naccarati A., Ohlsson B., Sjöberg K., Boutron-Ruault M.C., Cadeau C., Fagherazzi G., Boeing H., Steffen A., Kühn T., Katzke V., Tjønneland A., Olsen A., Khaw K.T., Wareham N., Key T., Lu Y., Riboli E., Peeters P.H., Gavrila D., Dorronsoro M., Quirõs J.R., Barricarte A., Jenab M., Zamora-Ros R., Freisling H., Trichopoulou A., Fonseca-Nunes A., Agudo A., Aranda N., Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, and Fonseca-Nunes A., Agudo A., Aranda N., Arija V., Cross A.J., Molina E., Sanchez M.J., Bueno-De-Mesquita H.B., Siersema P., Weiderpass E., Krogh V., Mattiello A., Tumino R., Saieva C., Naccarati A., Ohlsson B., Sjöberg K., Boutron-Ruault M.C., Cadeau C., Fagherazzi G., Boeing H., Steffen A., Kühn T., Katzke V., Tjønneland A., Olsen A., Khaw K.T., Wareham N., Key T., Lu Y., Riboli E., Peeters P.H., Gavrila D., Dorronsoro M., Quirõs J.R., Barricarte A., Jenab M., Zamora-Ros R., Freisling H., Trichopoulou A., Fonseca-Nunes A., Agudo A., Aranda N.

Abstract

Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2 ?=?0.80, 95% CI?=?0.72-0.88; OR10%increment ?=?0.87, 95% CI?=?0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity?=?0.04 and TS had a p for heterogeneity?=?0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl ?=?1.13, 95% CI?=?1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity?=?0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify t

Published
2015

197. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC)

Author

Lahmann, P. H., Hoffmann, K., Allen, N., Gils, C. H., Khaw, K. T., Tehard, B., Berrino, F., Tjønneland, A., Bigaard, J., Anja Viendahl Olsen, Kim Overvad, Clavel-Chapelon, F., Nagel, G., Boeing, H., Trichopoulos, D., Economou, G., Bellos, G., Palli, D., Tumino, R., Panico, S., Sacerdote, C., Krogh, V., Peeters, P. H., Bueno-De-Mesquita, H. B., Lund, E., Ardanaz, E., Amiano, P., Pera, G., Quiros, J. R., Martinez, C., Tormo, M. J., Wirfalt, E., Berglund, G., Hallmans, G., Key, T. J., Reeves, G., Bingham, S., Norat, T., Biessy, C., Kaaks, R., Riboli, E., Lahmann, Ph, Hoffmann, K, Allen, N, VAN GILS, Ch, Khaw, Kt, Tehard, B, Berrino, F, Tjonneland, A, Bigaard, J, Olsen, A, Overvad, K, CLAVEL CHAPELON, F, Nagel, G, Boeing, H, Trichopoulos, D, Economou, G, Bellos, G, Palli, D, Tumino, R, Panico, Salvatore, Sacerdote, C, Krogh, V, Peeters, Ph, BUENO DE MESQUITA, Hb, Lund, E, Ardanaz, E, Amiano, P, Pera, G, Quiros, Jr, Martinez, C, Tormo, Mj, Wirfalt, E, Berglund, G, Hallmans, G, Key, Tj, Reeves, G, Bingham, S, Norat, T, Biessy, C, Kaaks, R, and Riboli, E.

Subjects
Adult, Hormone Replacement Therapy, Incidence, Body Weight, Nutritional Status, Breast Neoplasms, Middle Aged, Body Height, Body Mass Index, Cohort Studies, Europe, Postmenopause, Adipose Tissue, Premenopause, Risk Factors, Abdomen, Body Composition, Humans, Female, Obesity, Prospective Studies, Aged
Abstract

The evidence for anthropometric factors influencing breast cancer risk is accumulating, but uncertainties remain concerning the role of fat distribution and potential effect modifiers. We used data from 73,542 premenopausal and 103,344 postmenopausal women from 9 European countries, taking part in the EPIC study. RRs from Cox regression models were calculated, using measured height, weight, BMI and waist and hip circumferences; categorized by cohort-wide quintiles; and expressed as continuous variables, adjusted for study center, age and other risk factors. During 4.7 years of follow-up, 1,879 incident invasive breast cancers were identified. In postmenopausal women, current HRT modified the body size-breast cancer association. Among nonusers, weight, BMI and hip circumference were positively associated with breast cancer risk (all ptrend < or = 0.002); obese women (BMI > 30) had a 31% excess risk compared to women with BMI < 25. Among HRT users, body measures were inversely but nonsignificantly associated with breast cancer. Excess breast cancer risk with HRT was particularly evident among lean women. Pooled RRs per height increment of 5 cm were 1.05 (95% CI 1.00-1.16) in premenopausal and 1.10 (95% CI 1.05-1.16) in postmenopausal women. Among premenopausal women, hip circumference was the only other measure significantly related to breast cancer (ptrend = 0.03), after accounting for BMI. In postmenopausal women not taking exogenous hormones, general obesity is a significant predictor of breast cancer, while abdominal fat assessed as waist-hip ratio or waist circumference was not related to excess risk when adjusted for BMI. Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer.

Published
2004

200. EPIC-Italy. A molecular epidemiology project on diet and cancer: the EPIC-Italy Prospective Study. Design and baseline characteristics of participants

Author

PALLI D, BERRINO F, VINEIS P, TUMINO R, MASALA G, SAIEVA C, SALVINI S, CEROTI M, PALA V, SIERI S, FRASCA G, GIURDANELLA MC, SACERDOTE C, FIORINI L, CELENTANO E, GALASSO R, DECARLI A, KROGH V., PANICO, SALVATORE, Palli, D, Berrino, F, Vineis, P, Tumino, R, Panico, Salvatore, Masala, G, Saieva, C, Salvini, S, Ceroti, M, Pala, V, Sieri, S, Frasca, G, Giurdanella, Mc, Sacerdote, C, Fiorini, L, Celentano, E, Galasso, R, Decarli, A, and Krogh, V.

Published
2003

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