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151. Existe-t-il des biomarqueurs lipidiques prédictifs du diabète de type 2 ? Application sur la cohorte Isphan Cohort Study (ICS)

Author

Trenteseaux, Charlotte, Ferchaud-Roucher, Véronique, Nobecourt-Dupuy, E, Krempf, Michel, Ouguerram, Khadija, Physiologie des Adaptations Nutritionnelles (PhAN), and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)

Subjects
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

152. Plasma lipidome characterization using UPLC-ESI-HRMS and ion mobility of hypertriglyceridemic patients on nicotinic acid

Author

Ferchaud-Roucher, Véronique, CROYAL, Mickael, Krempf, Michel, Ouguerram, Khadija, Physiologie des Adaptations Nutritionnelles (PhAN), and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)

Subjects
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

153. A relevant glucose-insulin dynamics model for type 1 diabetes

Author

Magdelaine, Nicolas, Chaillous, Lucy, Guilhem, Isabelle, Poirier, Jean-Yves, Krempf, Michel, Moog, Claude H., Le Carpentier, Eric, Institut de Recherche en Communications et en Cybernétique de Nantes (IRCCyN), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS), Clinique d'Endocrinologie, Maladies Métaboliques et Nutrition, Hôpital Laennec, Centre Hospitalier Universitaire [Rennes], Institut du thorax, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), and CHU Pontchaillou [Rennes]

Subjects
[INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, [SDV]Life Sciences [q-bio], functional insulin therapy, Type 1 Diabetes, Modeling, clinical data, Glycemia, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Type I Diabetes
Abstract

International audience; Several models have been developed for decades. These models have an inherent drawback: for each blood glucose value, a different insulin infusion rate is needed to maintain constant blood glucose level. The objective is to review the elementary modelling to eliminate this contradiction with real life. A new model is derived for type-I diabetics. It has realistic asymptotic properties as there is one single constant insulin infusion rate, known as the basal rate, independent on the glycemia, and which ensures the equilibrium of any value of the glycemia in fasting periods as it is in real life. A standard identification algorithm is used to get the patients’ individual characteristics. Standard clinical data (CGM, injection, CHO uptake) were analyzed for a typical type-I diabetic outpatient. A long term fit over two days with constant parameters is realized. Moreover, the new model provides the computation of the tools for the functional insulin therapy like basal infusion rate, the insulin sensitivity factor (ISF) or insulin to carbo ration (I:C). This is a major outcome as it can be used for the education of type-I diabetics.

Published
2015

154. [Does a slight overweight increase life expectancy?]

Author

Krempf, Michel, Physiologie des Adaptations Nutritionnelles (PhAN), and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)

Subjects
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

155. A consensus statement on lipid management after acute coronary syndrome

Author

Schiele, François, Farnier, Michel, Krempf, Michel, Bruckert, Eric, Ferrières, Jean, Angoulvant, Denis, Boccara, Franck, Bonnet, Jacques, Bonnet, Jean-Louis, Bruckert, Eric, Cayla, Guillaume, Chatot, Marion, Chopard, Romain, Collet, Jean-Philippe, Danchin, Nicolas, Ducrocq, Gregory, Elbaz, Meyer, Ferrari, Emile, Galinier, Michel, Farnier, Michel, Ferrières, Jean, Gerbaud, Edouard, Guedj, Dominique, Kownator, Serge, Krempf, Michel, Lemesle, Gilles, Levai, Laszlo, Mansencal, Nicolas, Mansourati, Jacques, Meune, Christophe, Morel, Olivier, Paillard, François, Piot, Christophe, Probst, Vincent, Puymirat, Etienne, Roubille, François, Sabouret, Pierre, Schiele, François, and Teiger, Emmanuel

Abstract

In patients admitted for acute coronary syndrome (ACS), the guidelines of the European Society of Cardiology give a Class I, Level A recommendation for the prescription of high-intensity statins to be initiated as early as possible, regardless of the low-density lipoprotein cholesterol (LDL-C) level. Although statins are widely prescribed after ACS, the intensity of therapy and the proportion of patients achieving target LDL-C values are often not in line with recommendations due to a lack of compliance with guidelines by the physicians, a lack of compliance with treatment or poor tolerance by patients, and poor dose adaptation. In this context, a group of French physicians came together to define strategies to facilitate and improve the management of lipid-lowering therapy after ACS. This paper outlines the scientific rationale for the use of statins at the acute phase of ACS, the utility of ezetimibe, the measurement of LDL-C during the course of ACS, the opportunities for detecting familial hypercholesterolaemia and the results of the consensus for the management of lipid-lowering therapy, illustrated in two decision-making algorithms.

Published
2018
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156. Bioavailability of starch and postprandial changes in splanchnic glucose metabolism in pigs

Author

NOAH, LIONEL, KREMPF, MICHEL, LECANNU, GERARD, MAUGERE, PASCALE, and CHAMP, MARTINE

Subjects
Bioavailability -- Physiological aspects, Swine -- Physiological aspects, Glucose metabolism -- Analysis, Biological sciences
Abstract

Noah Lionel, Michel Krempf, Gerard Lecannu, Pascale Maugere, and Martine Champ. Bioavailability of starch and postprandial changes in splanchnic glucose metabolism in pigs. Am. J. Physiol. Endocrinol. Metab. 278: E181--E188, 2000.--Changes in splanchnic metabolism in pigs were assessed after meals containing slowly or rapidly digested starch. The pigs were fed a mixed meal containing a 'slow' native (n = 5) or a 'rapid' pregelatinized (n = 5) cornstarch naturally enriched with [.sup.13]C]glucose. Absorption of [sup.13]C]glucose was monitored by the arteriovenous difference technique, and infusion of D-[6,[6-.sup.2][H.sub.2]]glucose in the jugular vein was used to calculate the systemic appearance of [sup.13]C]glucose. Arteriovenous balance data obtained during a 12-h study period showed that the fraction of ingested glucose equivalent appearing as glucose in the portal vein was 49.7 [+ or -] 7.2% for the slow starch and 48.2 [+ or -] 7.5% for the rapid starch (P = 0.86). These values, corrected for the gut extraction of circulating [.sup.13]C]glucose, became 66.4 [+ or -] 5.6 and 65.3 [+ or -] 5.6%, respectively (P = 0.35). Isotope dilution data indicated that systemic appearance of exogenous [[.sup.13]C]glucose represented 62.9 [+ or -] 7.6 and 67.4 [+ or -] 3.0% of the oral load for slow and rapid starch, respectively (P = 0.68). Arterial glucose utilization by the gut increased from 7.3 [+ or -] 0.9 [micro]mol [multiplied by] [kg.sup.-1] [multiplied by] [min.sup.-1] before the meal to 8.5 [+ or -] 1.6 [micro]mol [multiplied by] [kg.sup.-1] [multiplied by] [min.sup.-1] during absorption, independently of the nature of the starch. Thus splanchnic glucose metabolism was unaffected by the nature of starch ingested. starch; glucose metabolism; stable isotope

Published
2000

157. Noninvasive tracing of human liver metabolism: comparison of phenylacetate and apoB-100 to sample glutamine

Author

DIRAISON, FREDERIQUE, LARGE, VALERIE, MAUGEAIS, CYRILLE, KREMPF, MICHEL, and BEYLOT, MICHEL

Subjects
Liver -- Physiological aspects, Metabolism -- Analysis, Glutamine -- Research, Mass spectrometry -- Usage, Gluconeogenesis -- Analysis, Biopsy -- Analysis, Diabetes -- Causes of, Biological sciences
Abstract

Diraison, Frederique, Valerie Large, Cyrille Mau. geais, Michel Krempf, and Michel Beylot. Noninvasive tracing of human liver metabolism: comparison of phenylacetate and apoB-100 to sample glutamine. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E529-E536, 1999.raThe labeling pattern of hepatic glutamine during infusion of [3-[sup.13]C]lactate provides information on liver intermediary metabolism and allows us to correct apparent gluconeogenic rates for isotopic dilution in the oxaloacetate (OAA) pool. Liver glutamine can be sampled by its conjugation with phenylacetate to form phenylacetylglutamine (PAGN) but also by purifying the glutamine of the apolipoproteinB-100 of very low-density lipoprotein (apoB-100-VLDL). We compared these methods in normal and non-insulin dependent diabetes subjects. We tested also whether apoB-100-VLDL alanine enrichment could solve the problem of dilution of gluconeogenic precursor enrichments between peripheral blood and liver (prehepatic dilution). In both normal and diabetic subjects, the labeling patterns of glutamine obtained from PAGN or apoB-100-VLDL were comparable. Therefore, metabolic fluxes and correction factors for dilution in the OAA pool were also comparable. With both methods, gluconeogenic rates were not increased in diabetic patients. Use of the enrichment of apoB-100-VLDL alanine to correct for prehepatic dilution led to high estimates of gluconeogenesis; it remains uncertain whether this enrichment provides a correct estimate of liver pyruvate enrichment. mass spectrometry; stable isotope; gluconeogenesis; chemical biopsy; diabetes

Published
1999

159. Comparison of gas chromatography–mass spectrometry and gas chromatography–combustion–isotope ratio mass spectrometry analysis for in vivo estimates of metabolic fluxes

Author

Croyal, Mikaël, primary, Bourgeois, Raphaëlle, additional, Ouguerram, Khadija, additional, Billon-Crossouard, Stéphanie, additional, Aguesse, Audrey, additional, Nguyen, Patrick, additional, Krempf, Michel, additional, Ferchaud-Roucher, Véronique, additional, and Nobécourt, Estelle, additional

Published
2016
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161. Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody

Author

Hopkins, Paul N., primary, Defesche, Joep, additional, Fouchier, Sigrid W., additional, Bruckert, Eric, additional, Luc, Gérald, additional, Cariou, Bertrand, additional, Sjouke, Barbara, additional, Leren, Trond P., additional, Harada-Shiba, Mariko, additional, Mabuchi, Hiroshi, additional, Rabès, Jean-Pierre, additional, Carrié, Alain, additional, van Heyningen, Charles, additional, Carreau, Valérie, additional, Farnier, Michel, additional, Teoh, Yee P., additional, Bourbon, Mafalda, additional, Kawashiri, Masa-aki, additional, Nohara, Atsushi, additional, Soran, Handrean, additional, Marais, A. David, additional, Tada, Hayato, additional, Abifadel, Marianne, additional, Boileau, Catherine, additional, Chanu, Bernard, additional, Katsuda, Shoji, additional, Kishimoto, Ichiro, additional, Lambert, Gilles, additional, Makino, Hisashi, additional, Miyamoto, Yoshihiro, additional, Pichelin, Matthieu, additional, Yagi, Kunimasa, additional, Yamagishi, Masakazu, additional, Zair, Yassine, additional, Mellis, Scott, additional, Yancopoulos, George D., additional, Stahl, Neil, additional, Mendoza, Johanna, additional, Du, Yunling, additional, Hamon, Sara, additional, Krempf, Michel, additional, and Swergold, Gary D., additional

Published
2015
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162. Carotid and femoral atherosclerotic plaques show different morphology.: Patterns of Peripheral Arterial Disease

Author

Herisson, Fanny, Heymann, Marie-Françoise, Chétiveaux, Maud, Charrier, Céline, Battaglia, Séverine, Pilet, Paul, Rouillon, Thierry, Krempf, Michel, Lemarchand, Patricia, Heymann, Dominique, Gouëffic, Yann, Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Service d'Anatomo-pathologie, Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Institut du thorax, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'ingénierie osteo-articulaire et dentaire (LIOAD), Service d'endocrinologie, CIC biothérapies CBT 0503 [Nantes], Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de chirurgie vasculaire, Centre hospitalier universitaire de Nantes (CHU Nantes), This study was supported by grant from La Fondation de L'Avenir (ET7-477)., and Lemarchand, Patricia

Subjects
MESH: Aged, MESH: Middle Aged, MESH: Carotid Arteries, MESH: Humans, Peripheral artery disease, MESH: Microscopy, Electron, Scanning, MESH: Immunohistochemistry, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Atherosclerosis, MESH: Metaplasia, Lipids, MESH: Lipids, MESH: Male, MESH: Prospective Studies, MESH: Endarterectomy, MESH: Cholesterol, MESH: Risk Factors, MESH: Calcium, cardiovascular system, cardiovascular diseases, MESH: Plaque, Atherosclerotic, MESH: Female, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Vascular calcification, MESH: Femoral Artery
Abstract

International audience; OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p

Published
2011

167. Liraglutide 3.0 mg Reduces Body Weight and Improves Cardiometabolic Risk Factors in Adults with Overweight/Obesity: The SCALE Obesity and Prediabetes Randomised Trial

Author

Lau, David C., primary, Krempf, Michel, additional, Astrup, Arne, additional, Le Roux, Carel W., additional, Fujioka, Ken, additional, Greenway, Frank, additional, Halpern, Alfredo, additional, Ortiz, Rafael Violante, additional, Wilding, John, additional, Boras, Damir, additional, Lilleøre, Søren Kruse, additional, and Pi-Sunyer, Xavier, additional

Published
2015
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168. Additional Analyses of the Weight-lowering Efficacy of Liraglutide 3.0 mg in Adults with Overweight and Obesity: The SCALE Obesity and Prediabetes Randomized Trial

Author

Lau, David C., primary, Greenway, Frank, additional, Fujioka, Ken, additional, Astrup, Arne, additional, Halpern, Alfredo, additional, Krempf, Michel, additional, Le Roux, Carel W., additional, Ortiz, Rafael Violante, additional, Wilding, John, additional, Lilleøre, Søren Kruse, additional, Boras, Damir, additional, and Pi-Sunyer, Xavier, additional

Published
2015
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169. Liraglutide 3.0 mg Reduces Body Weight and Improves Health-Related Quality of Life (HRQoL) in Overweight or Obese Adults without Diabetes: The SCALE Obesity and Prediabetes Randomized, Double-Blind, Placebo-Controlled, 56-Week Trial

Author

Liutkus, Joanne F., primary, Fujioka, Ken, additional, Astrup, Arne, additional, Greenway, Frank, additional, Halpern, Alfredo, additional, Krempf, Michel, additional, Lau, David C., additional, Le Roux, Carel W., additional, Violante Ortiz, Rafael, additional, Wilding, John, additional, Wolden, Michael L., additional, Boras, Damir, additional, and Pi-Sunyer, Xavier, additional

Published
2015
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172. Use of advanced cluster analysis to characterize seafood consumption patterns and methylmercury exposures among pregnant women

Author

Pouzaud, François, Ibbou, Assia, Blanchemanche, Sandrine, Grandjean, Philippe, Krempf, Michel, Philippe, Henri-Jean, Verger, Philippe, Statistique, Analyse et Modélisation Multidisciplinaire (SAmos-Marin Mersenne) (SAMM), and Université Paris 1 Panthéon-Sorbonne (UP1)

Subjects
fish, [STAT.AP]Statistics [stat]/Applications [stat.AP], dietary exposure, non-supervised clustering, biomarker, methylmercury, pregnancy, [STAT.OT]Statistics [stat]/Other Statistics [stat.ML]
Abstract

International audience; On account of the interspecies variability in contamination and nutrient contents, consumers must balance the risks and benefits of fish consumption through their choice of species, meal size and frequency. The objectives of this study were to better characterize the risk of methylmercury (MeHg) exposure in a sample of 161 French pregnant women consuming sea food, including fish, molluscs and crustaceans, and to explore the use of unsupervised statistical learning as an advanced type of cluster analysis to identify patterns of fish consumption that could predict exposure to MeHg and the coverage of the Recommended Daily Allowance for n-3 polyunsaturated fatty acid (PUFA). The proportion of about 5% of pregnant women exposed at levels higher than the tolerable weekly intake for MeHg is similar to that observed among women of childbearing age in earlier French studies. At the same time, only about 50% of the women reached the recommended intake of 500 mg/day n-3 PUFA. Cluster analysis of the fish consumption showed that they could be grouped in five major clusters that are largely predictable of the intake of both MeHg and n-3 PUFA. This study shows that a global increase in seafood consumption could lead to MeHg exposure above the toxicological limits for pregnant women, thereby questioning the overall balance between this potential risk and potential beneficial effects of n-3 PUFA intakes. Only pregnant women consuming a high proportion of fatty fish meet the n-3 PUFA intake requirements without exceeding the toxicological limit for MeHg. The clusters identified suggest that different intervention strategies may be needed to address the dual purpose of ensuring high PUFA intakes at acceptable MeHg exposures.

Published
2010

173. PCSK9 dominant negative mutant results in increased LDL catabolic rate and familial hypobetalipoproteinemia

Author

Le May, Cedric, Cariou, Bertrand, Ouguerram, Khadija, Zaïr, Yassine, Guerois, Raphael, Langhi, Cédric, Kourimate, Sanae, Benoit, Isabelle, Le May, Cédric, Gayet, Constance, Belabbas, Khaldia, Dufernez, Fabienne, Chétiveaux, Maud, Tarugi, Patrizia, Krempf, Michel, Benlian, Pascale, Costet, Philippe, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Proband, Male, Apolipoprotein B, 030204 cardiovascular system & hematology, PCSK9, LDL, mutation, hypobetalipoproteinemia, Hypobetalipoproteinemias, chemistry.chemical_compound, 0302 clinical medicine, Missense mutation, ComputingMilieux_MISCELLANEOUS, Genes, Dominant, 0303 health sciences, Serine Endopeptidases, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Middle Aged, Recombinant Proteins, Pedigree, Kexin, Female, Proprotein Convertases, Proprotein Convertase 9, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, Heterozygote, Mutation, Missense, Biology, Transfection, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, 030304 developmental biology, Apolipoproteins B, Cholesterol, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Cholesterol, LDL, medicine.disease, Kinetics, Endocrinology, chemistry, Amino Acid Substitution, Hypobetalipoproteinemia, Familial, Apolipoprotein B, biology.protein, Hepatocytes, Hypobetalipoproteinemia, Lipoprotein
Abstract

Objective— Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a central player in the regulation of cholesterol homeostasis, increasing the low-density lipoprotein (LDL) receptor degradation. Our study aimed at exploring the pathogenic consequences in vivo and in vitro of a PCSK9 prodomain mutation found in a family with hypobetalipoproteinemia (FHBL). Methods and Results— A white 49-year-old diabetic man had profound FBHL (LDLC: 16 mg/dL) whereas his daughter and sister displayed a milder phenotype (LDLC 44 mg/dL and 57 mg/dL, respectively), all otherwise healthy with a normal liver function. A monoallelic PCSK9 double-mutant R104C/V114A cosegregated with FBHL, with no mutation found at other FHBL-causing loci. A dose-effect was also found in FBHL relatives for plasma APOB and PCSK9 (very-low to undetectable in proband, ≈50% decreased in sister and daughter) and LDL catabolic rate (256% and 88% increased in proband and daughter). Transient transfection in hepatocytes showed severely impaired processing and secretion of the double mutant which acted as a dominant negative over secretion of wild-type PCSK9. Conclusion— These results show that heterozygous PCSK9 missense mutations may associate with profound hypobetalipoproteinemia and constitute the first direct evidence in human that decrease of plasma LDLC concentrations associated to PCSK9 LOF mutations are attributable to an increased clearance rate of LDL.

Published
2009

174. Use of advanced cluster analysis to characterize seafood consumption patterns and methyle mercury exposures among pregnant women

Author

Pouzaud, François, Ibbou, Assia, Blanchemanche, Sandrine, Grandjean, Philippe, Krempf, Michel, Verger, Philippe, Méthodologies d'Analyse de Risque Alimentaire (MET@RISK), Institut National de la Recherche Agronomique (INRA), Statistique Appliquée et MOdélisation Stochastique (SAMOS), Université Panthéon-Sorbonne (UP1), Centre d'économie de la Sorbonne (CES), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Sciences de la Terre (LST), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Biologie et physiopathologie intestinales. Pharmacologie nutritionnelle, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 1 Panthéon-Sorbonne (UP1), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
fish, dietary exposure, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], nonsupervised clustering, biomarker, Methylmercury, pregnancy, [STAT.TH]Statistics [stat]/Statistics Theory [stat.TH]
Abstract

Because of the variability in food contamination and nutrient contents, consumers must balance the risks and benefits of fish consumption through their choice of species, meal size and frequency. The objectives of this study were to characterize the risk of MeHg exposure in French pregnant women consuming fish, and to explore the use of unsupervised statistical learning as an advanced type of cluster analysis to identify patterns of fish consumption that could predict exposure to MeHg and the coverage of the Recommended Daily Allowance for n-3 PUFA. The proportion of pregnant women exposed at levels higher than the Tolerable Weekly Intake (PTWI) for MeHg is similar to that observed amongst women of childbearing age in previous French studies. At the same time, only about 50% of the women reached the recommended intake of 500 mg/day n-3 PUFA. Cluster analysis of the fish consumption showed that they could be grouped in five major clusters that are largely predictable of the intake of both MeHg and n-3 PUFA. This study provides demonstrates that a global increase in seafood consumption could lead to MeHg exposure above the toxicological limits, thereby questioning the potential beneficial effects of n-3 PUFA intakes.

Published
2008

178. Proprotein convertase subtilisin/kexin type 9 (PCSK9) expression is regulated by insulin, sterol regulator element binding protein 1C (SREBP 1c) and the peroxisome proliferator-activated receptor a (PPARa)

Author

Costet, P, Cariou, Bruno, Pineau, Thierry, Krempf, Michel, Inconnu, Département Santé Animale (DEPT SA), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

179. Fasting induces hyperlipidemia in mice overexpressing PCSK9

Author

Lambert, G, Pineau, Thierry, Krempf, Michel, Costet, P, Inconnu, Département Santé Animale (DEPT SA), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

180. Proprotein Convertase Subtilisin/Kexin type 9 is repressed by PPARa and its overexpression during fasting results in massive hypertryglyceridemia

Author

Costet, P, Pineau, Thierry, Kourinate, S, Jarnoux, A-L, Krempf, Michel, Lambert, G, Inconnu, Département Santé Animale (DEPT SA), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2006

181. Proprotein convertase subtilisin/kexin type 9 (PCSK9) expression is regulated by insulin, an its overexpression during fasting results in hyperlipidaemia

Author

Costet, P, Cariou, Bruno, Pineau, Thierry, Krempf, Michel, Lambert, G, ProdInra, Migration, Inconnu, Département Santé Animale (DEPT SA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

183. Childhood obesity and insulin resistance in a Yucatan mini-piglet model : putative roles of IGF-1 and muscle PPARs in adipose tissue activity and development

Author

Sébert, S., Lecannu, G., Kozlowski, F., Siliart, B., Bard, J.M., Krempf, Michel, Champ, Martine, Unité de recherche Fonctions Digestives et de Nutrition Humaines (UFDNH), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, IGF 1, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2005

184. Bioavailability of starch, rate of glucose absorption and intestinal metabolism in pigs

Author

Noah, L., Lecannu, G., Maugère, P., Krempf, Michel, Champ, Martine, Unité de recherche Fonctions Digestives et de Nutrition Humaines (UFDNH), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1998

185. Measurement of exogenous acetate production during colonic fermentation of lactulose using (1-13C) acetate in humans

Author

Pouteau, E., Vahedi, K., Messing, B., CHAMP, Martine, Nguyen, P., Krempf, Michel, ProdInra, Migration, F. Guillon (Editeur), Laboratoire de technologie appliquée à la nutrition, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1998

186. Thiazolidinedione use is not associated with worse cardiovascular outcomes: A study in 28,332 high risk patients with diabetes in routine clinical practice

Author

Roussel, Ronan, primary, Hadjadj, Samy, additional, Pasquet, Blandine, additional, Wilson, Peter W.F., additional, Smith, Sidney C., additional, Goto, Shinya, additional, Tubach, Florence, additional, Marre, Michel, additional, Porath, Avi, additional, Krempf, Michel, additional, Bhatt, Deepak L., additional, and Steg, P. Gabriel, additional

Published
2013
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188. Acebutolol and alprenolol metabolism predictions: comparative study of electrochemical and cytochrome P450-catalyzed reactions using liquid chromatography coupled to high-resolution mass spectrometry

Author

Bussy, Ugo, primary, Delaforge, Marcel, additional, El-Bekkali, Chaimaâ, additional, Ferchaud-Roucher, Véronique, additional, Krempf, Michel, additional, Tea, Illa, additional, Galland, Nicolas, additional, Jacquemin, Denis, additional, and Boujtita, Mohammed, additional

Published
2013
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191. Voltammetry coupled to mass spectrometry in the presence of isotope 18O labeled water for the prediction of oxidative transformation pathways of activated aromatic ethers: Acebutolol

Author

Bussy, Ugo, primary, Tea, Illa, additional, Ferchaud-Roucher, Véronique, additional, Krempf, Michel, additional, Silvestre, Virginie, additional, Galland, Nicolas, additional, Jacquemin, Denis, additional, Andresen-Bergström, Moa, additional, Jurva, Ulrik, additional, and Boujtita, Mohammed, additional

Published
2013
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192. Integration of microbiology and infectious disease teaching courses in an interdisciplinary training programme (Master level) centred on the 'One world, one health' WHO concept.

Author

Eveillard, Matthieu, Ruvoen, Nathalie, Lepelletier, Didier, Fradet, Stèphanie, Couvreur, èbastien, Krempf, Michel, and Magras, Catherine

Subjects
INTERDISCIPLINARY education, MICROBIOLOGY education, COMMUNICABLE diseases, MULTICULTURALISM -- Social aspects, EDUCATION
Abstract

This report describes the integration of the microbiology and infectious diseases teaching courses in an international Master's level interdisciplinary programme based on the 'One world, one health' WHO concept, and reports the students and teachers' evaluation related to their feelings of about this innovative programme. The integration was evaluated by recording the positioning of these two topics in the five teaching units constituting the programme, and by identifying their contribution in the interactions between the different teaching units. The satisfaction of students was assessed by a quantitative survey, whereas the feelings of students and teachers were assessed by interviews. The study demonstrated that microbiology and infectious diseases were widely involved in interactions between the teaching units, constituting a kind of cement for the programme. The students assigned a mean score of 3.7 to the topics dealing with microbiology and infectious diseases. According to the qualitative data, students and teachers considered that the interdisciplinary approach provided new insights but reported problems of communication, probably inherent to the multiculturalism of the class. [ABSTRACT FROM AUTHOR]

Published
2016
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193. Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet.

Author

Kasbi-Chadli, Fatima, Ferchaud-Roucher, Véronique, Krempf, Michel, and Ouguerram, Khadija

Subjects
LIPID metabolism, ANALYSIS of triglycerides, ANIMAL experimentation, BODY weight, CHOLESTEROL, DIETARY supplements, GLUCOSE tolerance tests, HAMSTERS, HISTOLOGICAL techniques, INGESTION, LIVER, MOTHERS, NUTRITIONAL requirements, OMEGA-3 fatty acids, POLYMERASE chain reaction, PROBABILITY theory, RESEARCH funding, STATISTICS, DATA analysis, GLUCOSE intolerance, DATA analysis software, SKELETAL muscle, DESCRIPTIVE statistics, PRENATAL exposure delayed effects, ONE-way analysis of variance, IN vivo studies, PREGNANCY
Abstract

Purpose: We recently reported that direct and maternal supplementation with n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) alleviates the metabolic disturbances in adult hamster pups fed with a high-fat diet (HFD). In this study, we hypothesized that these results involved a perinatal modulating effect of sphingolipids by n-3 LC-PUFA. Methods: We studied the effect of direct and maternal n-3 LC-PUFA supplementation on sphingolipid contents in liver and muscle, hepatic triglycerides (TG) secretion and glucose tolerance. Offspring male hamsters born from supplemented (Cω) or unsupplemented (C) mothers were subjected after weaning to a HFD during 16 weeks, without (Cω-HF or C-HF) or with direct supplementation with n-3 LC-PUFA (C-HFω). Results: Direct supplementation decreased sphingosine, sphinganine and ceramides in liver and decreased sphingosine, sphinganine, sphingosine-1-phosphate (S1P) and ceramides in muscle in C-HFω compared to C-HF ( p < 0.05). Maternal supplementation decreased C20 ceramide and lactosylceramide in liver and sphinganine, S1P and lactosylceramide in muscle ( p < 0.05). This supplementation tended to decrease glucosylceramide in liver ( p < 0.06) and muscle ( p < 0.07) in Cω-HF compared to C-HF. Direct supplementation increased glucose tolerance and decreased hepatic TG secretion and hepatic gene expression levels of diacylglycerol O-acyltransferase 2 (DGAT2), sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase, stearoyl-CoA desaturase-1 (SCD1) and tumor necrosis factor α (TNFα). Maternal supplementation decreased basal glycemia and hepatic TG secretion. We observed a positive correlation between hepatic TG secretion and hepatic ceramide ( p = 0.0059), and between basal glycemia and hepatic ceramide ( p = 0.04) or muscle lactosylceramide contents ( p = 0.001). Conclusion: We observed an improvement of lipids and glucose metabolism in hamster with n-3 LC-PUFA direct supplementation and a decrease in glycemia and hepatic TG secretion with maternal supplementation. These results are probably related to a decrease in both lipogenesis and sphingolipid contents in liver and muscle. [ABSTRACT FROM AUTHOR]

Published
2016
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195. Aliment et santé. Quels glucoses dans les aliments pour garantir notre santé ?

Author

CHAMP, Martine, Krempf, Michel, Darmaun, D., Laboratoire de technologie appliquée à la nutrition, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, METHODOLOGIE
Abstract

National audience

Published
1997

196. Kinetic aspects of acetate metabolism in healthy humans using (1 -13 C) acetate

Author

Pouteau, E., Piloquet, Hugues, Maugeais, P., Champ, Martine, Dumon, H., Nguyen, P., Krempf, Michel, Laboratoire de technologie appliquée à la nutrition, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1996

197. Exploration du métabolisme par les isotopes stables in vivo chez l'homme

Author

Darmaun, D., Bard, J.M., Ouguerram, Khadija, Magot, T., Champ, Martine, Maugère, R., Krempf, Michel, Laboratoire de technologie appliquée à la nutrition, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

La santé en pays de la Loire; National audience

Published
1996

198. Low Rate of Production of Apolipoproteins B100 and AI in 2 Patients With Anderson Disease (Chylomicron Retention Disease)

Author

Ouguerram, Khadija, primary, Zaïr, Yassine, additional, Kasbi-Chadli, Fatima, additional, Nazih, Hassane, additional, Bligny, Dominique, additional, Schmitz, Jacques, additional, Aparicio, Thomas, additional, Chétiveaux, Maud, additional, Magot, Thierry, additional, Aggerbeck, Laurence P., additional, Samson-Bouma, Marie Elisabeth, additional, and Krempf, Michel, additional

Published
2012
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